ZYG11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycine metabolic process (GO:0006544)5.11186832
2serine family amino acid catabolic process (GO:0009071)4.74868418
3purine nucleobase biosynthetic process (GO:0009113)4.62344152
4behavioral response to nicotine (GO:0035095)4.53418481
5folic acid metabolic process (GO:0046655)4.52507279
6nucleobase biosynthetic process (GO:0046112)4.42936517
7nuclear pore organization (GO:0006999)4.18412880
8response to pheromone (GO:0019236)4.18179984
9synapsis (GO:0007129)4.13330257
10serine family amino acid metabolic process (GO:0009069)4.09005679
11mitotic metaphase plate congression (GO:0007080)4.04872517
12serine family amino acid biosynthetic process (GO:0009070)3.94868758
13nuclear pore complex assembly (GO:0051292)3.83890859
14regulation of gene silencing by RNA (GO:0060966)3.83145141
15regulation of posttranscriptional gene silencing (GO:0060147)3.83145141
16regulation of gene silencing by miRNA (GO:0060964)3.83145141
17meiotic chromosome segregation (GO:0045132)3.81377165
18DNA methylation involved in gamete generation (GO:0043046)3.76950859
19DNA deamination (GO:0045006)3.72423023
20replication fork processing (GO:0031297)3.66839133
21cysteine metabolic process (GO:0006534)3.65700597
22ribosome assembly (GO:0042255)3.65386553
23DNA replication checkpoint (GO:0000076)3.60176088
24male meiosis I (GO:0007141)3.58263175
25L-phenylalanine metabolic process (GO:0006558)3.46594389
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.46594389
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.44918962
28L-phenylalanine catabolic process (GO:0006559)3.44918962
29L-serine metabolic process (GO:0006563)3.43602334
30regulation of spindle organization (GO:0090224)3.43016043
31DNA replication-dependent nucleosome assembly (GO:0006335)3.42878387
32DNA replication-dependent nucleosome organization (GO:0034723)3.42878387
33mitotic nuclear envelope disassembly (GO:0007077)3.40001347
34protein localization to kinetochore (GO:0034501)3.38856627
35folic acid-containing compound biosynthetic process (GO:0009396)3.38366816
36reciprocal meiotic recombination (GO:0007131)3.38103440
37reciprocal DNA recombination (GO:0035825)3.38103440
38metaphase plate congression (GO:0051310)3.38014443
39mitochondrial RNA metabolic process (GO:0000959)3.36708706
40formation of translation preinitiation complex (GO:0001731)3.35432787
41ribosome biogenesis (GO:0042254)3.34224477
42regulation of hippo signaling (GO:0035330)3.33441676
43male meiosis (GO:0007140)3.29649684
44homocysteine metabolic process (GO:0050667)3.26326289
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25509458
46double-strand break repair via homologous recombination (GO:0000724)3.25374174
47sulfation (GO:0051923)3.24775569
48recombinational repair (GO:0000725)3.24228667
49water-soluble vitamin biosynthetic process (GO:0042364)3.23124752
50sulfur amino acid catabolic process (GO:0000098)3.21946307
51pseudouridine synthesis (GO:0001522)3.21322173
52aromatic amino acid family catabolic process (GO:0009074)3.20848891
53negative regulation of fatty acid biosynthetic process (GO:0045717)3.16248526
54protein-cofactor linkage (GO:0018065)3.15305696
55nuclear envelope disassembly (GO:0051081)3.15056309
56membrane disassembly (GO:0030397)3.15056309
57positive regulation of chromosome segregation (GO:0051984)3.11535860
58vitamin transmembrane transport (GO:0035461)3.09405343
59kynurenine metabolic process (GO:0070189)3.08301770
60L-fucose catabolic process (GO:0042355)3.08050894
61fucose catabolic process (GO:0019317)3.08050894
62L-fucose metabolic process (GO:0042354)3.08050894
63indolalkylamine metabolic process (GO:0006586)3.07901850
64piRNA metabolic process (GO:0034587)3.07631936
65protein K6-linked ubiquitination (GO:0085020)3.06781847
66tryptophan catabolic process (GO:0006569)3.04431888
67indole-containing compound catabolic process (GO:0042436)3.04431888
68indolalkylamine catabolic process (GO:0046218)3.04431888
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02992018
70mitochondrial respiratory chain complex I assembly (GO:0032981)3.02992018
71NADH dehydrogenase complex assembly (GO:0010257)3.02992018
72preassembly of GPI anchor in ER membrane (GO:0016254)3.01745620
73mitochondrial respiratory chain complex assembly (GO:0033108)3.00990293
74rRNA catabolic process (GO:0016075)3.00673777
75mitotic sister chromatid segregation (GO:0000070)2.99618432
76urea metabolic process (GO:0019627)2.99303453
77urea cycle (GO:0000050)2.99303453
78protein complex biogenesis (GO:0070271)2.98847752
79maturation of 5.8S rRNA (GO:0000460)2.98486364
80DNA replication initiation (GO:0006270)2.98155312
81synaptonemal complex assembly (GO:0007130)2.97516165
82folic acid-containing compound metabolic process (GO:0006760)2.96787433
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95869336
84cellular ketone body metabolic process (GO:0046950)2.95161549
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.92791626
86resolution of meiotic recombination intermediates (GO:0000712)2.92443811
87folic acid transport (GO:0015884)2.92139796
88regulation of mitotic spindle organization (GO:0060236)2.91533438
89pore complex assembly (GO:0046931)2.91300524
90regulation of DNA endoreduplication (GO:0032875)2.91001173
91attachment of spindle microtubules to kinetochore (GO:0008608)2.90677004
92regulation of protein activation cascade (GO:2000257)2.89894091
93intestinal epithelial cell development (GO:0060576)2.89423954
94tryptophan metabolic process (GO:0006568)2.89375233
95negative regulation of DNA-dependent DNA replication (GO:2000104)2.87999490
96sulfur amino acid biosynthetic process (GO:0000097)2.87885705
97glyoxylate metabolic process (GO:0046487)2.86880820
98regulation of centriole replication (GO:0046599)2.86558342
99regulation of meiosis I (GO:0060631)2.86023083
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85762723
101somatic hypermutation of immunoglobulin genes (GO:0016446)2.85686804
102somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85686804
103pre-miRNA processing (GO:0031054)2.84552771
104chromosome organization involved in meiosis (GO:0070192)2.83138068
105tRNA modification (GO:0006400)2.83048242
106triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81935190
107pantothenate metabolic process (GO:0015939)2.81330872
108tRNA processing (GO:0008033)2.81037466
109meiosis I (GO:0007127)2.80641283
110negative regulation of chromosome segregation (GO:0051985)2.79537881
111heterochromatin organization (GO:0070828)2.78760012
112methionine biosynthetic process (GO:0009086)2.77465871
113respiratory chain complex IV assembly (GO:0008535)2.77403098
114regulation of helicase activity (GO:0051095)2.77218764
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77202566
116tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77202566
117mitotic chromosome condensation (GO:0007076)2.77040519
118tetrahydrofolate metabolic process (GO:0046653)2.76705158
119protein localization to chromosome, centromeric region (GO:0071459)2.76663879
120amino-acid betaine metabolic process (GO:0006577)2.75774414
121alpha-amino acid catabolic process (GO:1901606)2.75486690
122bile acid biosynthetic process (GO:0006699)2.75138481
123regulation of chromosome segregation (GO:0051983)2.74284885
124regulation of complement activation (GO:0030449)2.74084341
125one-carbon metabolic process (GO:0006730)2.72827383
126histone H4-K12 acetylation (GO:0043983)2.72353091
127spindle checkpoint (GO:0031577)2.71722489
128mitotic spindle checkpoint (GO:0071174)2.71524272
129nitrogen cycle metabolic process (GO:0071941)2.71235015
130biotin metabolic process (GO:0006768)2.71232480
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70419694
132chaperone-mediated protein complex assembly (GO:0051131)2.66688358
133complement activation, alternative pathway (GO:0006957)2.66568959
134mitotic spindle assembly checkpoint (GO:0007094)2.65921305
135regulation of mitotic spindle checkpoint (GO:1903504)2.65535424
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65535424
137aromatic amino acid family metabolic process (GO:0009072)2.65361100
138regulation of RNA export from nucleus (GO:0046831)2.64923619
139inner cell mass cell proliferation (GO:0001833)2.64557791
140spindle assembly checkpoint (GO:0071173)2.64555148
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64416335
142negative regulation of sister chromatid segregation (GO:0033046)2.64416335
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.64416335
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64416335
145chromatin remodeling at centromere (GO:0031055)2.64061019
146negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64012896
147detection of light stimulus involved in visual perception (GO:0050908)2.63895527
148detection of light stimulus involved in sensory perception (GO:0050962)2.63895527
149heme transport (GO:0015886)2.62857501
150IMP biosynthetic process (GO:0006188)2.62664673
151regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61533890
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.61134781
153regulation of translational termination (GO:0006449)2.61114758
154ketone body metabolic process (GO:1902224)2.60467039
155regulation of centrosome cycle (GO:0046605)2.60232881
156multicellular organism reproduction (GO:0032504)2.58559340
157rRNA methylation (GO:0031167)2.57755909
158postreplication repair (GO:0006301)2.56973358
159nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56195021
160centriole replication (GO:0007099)2.55366416
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55110375
162peptidyl-histidine modification (GO:0018202)2.54882028
163proteasome assembly (GO:0043248)2.53680176
164protein polyglutamylation (GO:0018095)2.53500818
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53007656
166rRNA modification (GO:0000154)2.52713248
167cellular response to ATP (GO:0071318)2.52002209
168cAMP catabolic process (GO:0006198)2.51729182
169indole-containing compound metabolic process (GO:0042430)2.51250982
170CENP-A containing nucleosome assembly (GO:0034080)2.49906205
171S-adenosylmethionine metabolic process (GO:0046500)2.47293380
172L-methionine salvage (GO:0071267)2.46533869
173L-methionine biosynthetic process (GO:0071265)2.46533869
174amino acid salvage (GO:0043102)2.46533869
175gene silencing by RNA (GO:0031047)2.46459693
176DNA double-strand break processing (GO:0000729)2.46218533
177tRNA metabolic process (GO:0006399)2.44849550
178regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44698399
179regulation of centrosome duplication (GO:0010824)2.43730281
180establishment of protein localization to mitochondrial membrane (GO:0090151)2.42205650
181cornea development in camera-type eye (GO:0061303)2.42035336
182meiotic cell cycle (GO:0051321)2.39976310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60291246
2ZNF274_21170338_ChIP-Seq_K562_Hela3.86653667
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.63153406
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46192203
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.44632312
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.05591821
7VDR_22108803_ChIP-Seq_LS180_Human3.00230320
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75533814
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69914016
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.68234349
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.68234349
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.68234349
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65056640
14EWS_26573619_Chip-Seq_HEK293_Human2.55578411
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.51976789
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45138822
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.44773029
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.43035789
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39828538
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38925247
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31070933
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31024883
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28591969
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28435606
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28412912
26FUS_26573619_Chip-Seq_HEK293_Human2.25905435
27AR_21909140_ChIP-Seq_LNCAP_Human2.20921488
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20181884
29IGF1R_20145208_ChIP-Seq_DFB_Human2.18653889
30NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18492156
31STAT3_1855785_ChIP-Seq_MESCs_Mouse2.16523481
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.16197415
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13453975
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11298369
35MYC_18940864_ChIP-ChIP_HL60_Human2.10383606
36ETS1_20019798_ChIP-Seq_JURKAT_Human2.09577352
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08251524
38NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07179811
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.06386126
40EGR1_23403033_ChIP-Seq_LIVER_Mouse2.03874883
41GBX2_23144817_ChIP-Seq_PC3_Human2.02297715
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00659743
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.97245329
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91577099
45ELK1_19687146_ChIP-ChIP_HELA_Human1.91511137
46EZH2_22144423_ChIP-Seq_EOC_Human1.90057918
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89121949
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87511438
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.86260907
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.84995965
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82987023
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79584108
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79314672
54IRF1_19129219_ChIP-ChIP_H3396_Human1.78714449
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76227617
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75426251
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74469120
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71156958
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69963779
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69033207
61* LXR_22158963_ChIP-Seq_LIVER_Mouse1.68141886
62ER_23166858_ChIP-Seq_MCF-7_Human1.67715735
63TP53_22573176_ChIP-Seq_HFKS_Human1.65360012
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.64291092
65XRN2_22483619_ChIP-Seq_HELA_Human1.62408662
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.61836472
67TCF3_18692474_ChIP-Seq_MESCs_Mouse1.59488377
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52875898
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.52145893
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51647329
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51626596
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51518309
73ZNF263_19887448_ChIP-Seq_K562_Human1.49282571
74TAF15_26573619_Chip-Seq_HEK293_Human1.49109177
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47040908
76KDM5A_27292631_Chip-Seq_BREAST_Human1.46284056
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46126787
78P300_19829295_ChIP-Seq_ESCs_Human1.45508001
79VDR_23849224_ChIP-Seq_CD4+_Human1.44170195
80GABP_19822575_ChIP-Seq_HepG2_Human1.43864859
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42993226
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41920172
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.40025059
84DCP1A_22483619_ChIP-Seq_HELA_Human1.38278729
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38103859
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37275047
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36947225
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36102270
89CBP_20019798_ChIP-Seq_JUKART_Human1.36102270
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33610607
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33017591
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.32824910
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32172805
94HOXB7_26014856_ChIP-Seq_BT474_Human1.31937992
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31852157
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31624213
97STAT3_23295773_ChIP-Seq_U87_Human1.31411340
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.29197933
99FOXP3_21729870_ChIP-Seq_TREG_Human1.28506065
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.27855989
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27059169
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.25175882
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25175882
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.23622995
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21424582
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20994642
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.20575072
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20287153
109SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19702404
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19256235
111RNF2_27304074_Chip-Seq_NSC_Mouse1.18913497
112SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17250920
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.16717235
114TCF4_23295773_ChIP-Seq_U87_Human1.16481369
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16090552
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16076654
117* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15785554
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15604928
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15596981
120NCOR_22424771_ChIP-Seq_293T_Human1.14418446
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12918719
122PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11647142
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10644610
124POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10253093
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09975680
126SOX2_19829295_ChIP-Seq_ESCs_Human1.09766351
127NANOG_19829295_ChIP-Seq_ESCs_Human1.09766351
128POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09506079
129OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09243260
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08820560
131AR_20517297_ChIP-Seq_VCAP_Human1.08275989
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07577326
133NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07293621
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07083471
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06412610
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03494215
137NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03197919
138NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02378095
139* TTF2_22483619_ChIP-Seq_HELA_Human1.01483447
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98005499
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97842807
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97168800
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97152633
144KAP1_27257070_Chip-Seq_ESCs_Mouse0.97052407
145TP63_19390658_ChIP-ChIP_HaCaT_Human0.96608287
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96112235
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95887923
148POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95217052
149ERA_21632823_ChIP-Seq_H3396_Human0.94723984
150TFEB_21752829_ChIP-Seq_HELA_Human0.94549014
151RUNX2_22187159_ChIP-Seq_PCA_Human0.94125738
152BCAT_22108803_ChIP-Seq_LS180_Human0.94009450
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93780612
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93679740
155PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93669197
156* PHF8_20622853_ChIP-Seq_HELA_Human0.92855270
157NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92602771
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.92600893
159* AR_25329375_ChIP-Seq_VCAP_Human0.92100914
160HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92072853
161* SMAD4_21799915_ChIP-Seq_A2780_Human0.91720517
162TCF4_22108803_ChIP-Seq_LS180_Human0.91538916
163BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91399356
164CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91248500
165FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91027510
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90711068
167KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89894027
168CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89573634
169TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89087979
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88485470
171* ETV1_20927104_ChIP-Seq_GIST48_Human0.87947377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.28386969
2MP0005360_urolithiasis4.10308360
3MP0003806_abnormal_nucleotide_metabolis3.93608280
4MP0005365_abnormal_bile_salt3.92175425
5MP0005085_abnormal_gallbladder_physiolo3.90651159
6MP0003693_abnormal_embryo_hatching3.57235087
7MP0003111_abnormal_nucleus_morphology3.44656468
8MP0004957_abnormal_blastocyst_morpholog3.27613707
9MP0010094_abnormal_chromosome_stability3.09826454
10MP0008057_abnormal_DNA_replication3.07971346
11MP0009840_abnormal_foam_cell2.81940570
12MP0005646_abnormal_pituitary_gland2.75758483
13MP0003077_abnormal_cell_cycle2.61059112
14MP0006292_abnormal_olfactory_placode2.44657446
15MP0003718_maternal_effect2.43444323
16MP0005551_abnormal_eye_electrophysiolog2.39521448
17MP0008875_abnormal_xenobiotic_pharmacok2.34211032
18MP0008877_abnormal_DNA_methylation2.21720060
19MP0008058_abnormal_DNA_repair2.21441039
20MP0002102_abnormal_ear_morphology2.11580973
21MP0006072_abnormal_retinal_apoptosis2.09905500
22MP0010329_abnormal_lipoprotein_level2.06782512
23MP0001730_embryonic_growth_arrest2.06421838
24MP0005645_abnormal_hypothalamus_physiol2.05361529
25MP0002876_abnormal_thyroid_physiology1.95358958
26MP0003786_premature_aging1.91460526
27MP0008872_abnormal_physiological_respon1.87748740
28MP0003252_abnormal_bile_duct1.81595008
29MP0003646_muscle_fatigue1.81085187
30MP0003705_abnormal_hypodermis_morpholog1.80394907
31MP0000631_abnormal_neuroendocrine_gland1.80020978
32MP0001968_abnormal_touch/_nociception1.77418599
33MP0005380_embryogenesis_phenotype1.75127865
34MP0001672_abnormal_embryogenesis/_devel1.75127865
35MP0005332_abnormal_amino_acid1.75068764
36MP0005253_abnormal_eye_physiology1.73955549
37MP0000427_abnormal_hair_cycle1.71655653
38MP0005083_abnormal_biliary_tract1.66122997
39MP0010307_abnormal_tumor_latency1.64136982
40MP0000350_abnormal_cell_proliferation1.61786378
41MP0004147_increased_porphyrin_level1.61483051
42MP0010352_gastrointestinal_tract_polyps1.61083219
43MP0001986_abnormal_taste_sensitivity1.58696394
44MP0003123_paternal_imprinting1.57847787
45MP0001919_abnormal_reproductive_system1.57660511
46MP0001666_abnormal_nutrient_absorption1.57383381
47MP0000609_abnormal_liver_physiology1.54166435
48MP0003890_abnormal_embryonic-extraembry1.53358917
49MP0004019_abnormal_vitamin_homeostasis1.52309900
50MP0003984_embryonic_growth_retardation1.50844552
51MP0002088_abnormal_embryonic_growth/wei1.49023836
52MP0008932_abnormal_embryonic_tissue1.48152516
53MP0002736_abnormal_nociception_after1.46034434
54MP0009046_muscle_twitch1.44317533
55MP0004264_abnormal_extraembryonic_tissu1.43980352
56MP0002086_abnormal_extraembryonic_tissu1.42309448
57MP0003937_abnormal_limbs/digits/tail_de1.40378037
58MP0004885_abnormal_endolymph1.40348767
59MP0004142_abnormal_muscle_tone1.39693208
60MP0001697_abnormal_embryo_size1.39497193
61MP0002210_abnormal_sex_determination1.38367449
62MP0003136_yellow_coat_color1.38343314
63MP0002163_abnormal_gland_morphology1.36823852
64MP0001661_extended_life_span1.36230097
65MP0002938_white_spotting1.36171221
66MP0004043_abnormal_pH_regulation1.34637143
67MP0000383_abnormal_hair_follicle1.30059382
68MP0001145_abnormal_male_reproductive1.28871622
69MP0005410_abnormal_fertilization1.28382305
70MP0002085_abnormal_embryonic_tissue1.27971597
71MP0002084_abnormal_developmental_patter1.27873100
72MP0000372_irregular_coat_pigmentation1.25164312
73MP0002080_prenatal_lethality1.24794905
74MP0004197_abnormal_fetal_growth/weight/1.24663064
75MP0001764_abnormal_homeostasis1.22819870
76MP0002653_abnormal_ependyma_morphology1.22495047
77MP0002837_dystrophic_cardiac_calcinosis1.22363163
78MP0008260_abnormal_autophagy1.21684580
79MP0005451_abnormal_body_composition1.21559536
80MP0008007_abnormal_cellular_replicative1.21482199
81MP0009745_abnormal_behavioral_response1.21171247
82MP0005319_abnormal_enzyme/_coenzyme1.20217260
83MP0002234_abnormal_pharynx_morphology1.17950352
84MP0001929_abnormal_gametogenesis1.17704860
85MP0008995_early_reproductive_senescence1.15701397
86MP0002928_abnormal_bile_duct1.15257747
87MP0009672_abnormal_birth_weight1.15102285
88MP0002272_abnormal_nervous_system1.14382094
89MP0002118_abnormal_lipid_homeostasis1.12703973
90MP0003186_abnormal_redox_activity1.12540363
91MP0003191_abnormal_cellular_cholesterol1.12300787
92MP0000647_abnormal_sebaceous_gland1.11699289
93MP0000653_abnormal_sex_gland1.10493739
94MP0005670_abnormal_white_adipose1.06916190
95MP0001485_abnormal_pinna_reflex1.06842979
96MP0002254_reproductive_system_inflammat1.05745943
97MP0006276_abnormal_autonomic_nervous1.04429023
98MP0000569_abnormal_digit_pigmentation1.03344366
99MP0005266_abnormal_metabolism1.03032494
100MP0005379_endocrine/exocrine_gland_phen1.02894904
101MP0000049_abnormal_middle_ear1.01620048
102MP0003119_abnormal_digestive_system1.00899666
103MP0004185_abnormal_adipocyte_glucose1.00365474
104MP0005395_other_phenotype0.99859413
105MP0004145_abnormal_muscle_electrophysio0.99832492
106MP0000598_abnormal_liver_morphology0.97557288
107MP0005647_abnormal_sex_gland0.96562633
108MP0005174_abnormal_tail_pigmentation0.96294481
109MP0003567_abnormal_fetal_cardiomyocyte0.96189406
110MP0003868_abnormal_feces_composition0.96139223
111MP0001293_anophthalmia0.95005740
112MP0002638_abnormal_pupillary_reflex0.94114417
113MP0005076_abnormal_cell_differentiation0.93933625
114MP0008789_abnormal_olfactory_epithelium0.92525900
115MP0002735_abnormal_chemical_nociception0.91016719
116MP0006035_abnormal_mitochondrial_morpho0.89500758
117MP0005195_abnormal_posterior_eye0.88509687
118MP0004742_abnormal_vestibular_system0.87834557
119MP0003221_abnormal_cardiomyocyte_apopto0.86464437
120MP0005666_abnormal_adipose_tissue0.86383676
121MP0002095_abnormal_skin_pigmentation0.84605326
122MP0009053_abnormal_anal_canal0.82980077
123MP0001502_abnormal_circadian_rhythm0.81266698
124MP0009703_decreased_birth_body0.81225437
125MP0008775_abnormal_heart_ventricle0.80184339
126MP0002752_abnormal_somatic_nervous0.79101301
127MP0003699_abnormal_female_reproductive0.79054093
128MP0002557_abnormal_social/conspecific_i0.78566062
129MP0005084_abnormal_gallbladder_morpholo0.77744143
130MP0005391_vision/eye_phenotype0.77666745
131MP0003938_abnormal_ear_development0.76758038
132MP0000313_abnormal_cell_death0.76037756
133MP0002184_abnormal_innervation0.75803038
134MP0001119_abnormal_female_reproductive0.75739180
135MP0003950_abnormal_plasma_membrane0.75627936
136MP0003195_calcinosis0.75530275
137MP0002092_abnormal_eye_morphology0.74604386
138MP0000358_abnormal_cell_content/0.74462735
139MP0006036_abnormal_mitochondrial_physio0.74146369
140MP0002019_abnormal_tumor_incidence0.73808265
141MP0009697_abnormal_copulation0.73746047
142MP0002269_muscular_atrophy0.73080614
143MP0002751_abnormal_autonomic_nervous0.72731022
144MP0005377_hearing/vestibular/ear_phenot0.71780268
145MP0003878_abnormal_ear_physiology0.71780268
146MP0003941_abnormal_skin_development0.70199401
147MP0002138_abnormal_hepatobiliary_system0.69370661
148MP0001324_abnormal_eye_pigmentation0.69352404
149MP0002796_impaired_skin_barrier0.69319137
150MP0003698_abnormal_male_reproductive0.69140200
151MP0001944_abnormal_pancreas_morphology0.68797717
152MP0002009_preneoplasia0.68193290
153MP0005187_abnormal_penis_morphology0.67395275
154MP0004133_heterotaxia0.66911351
155MP0002161_abnormal_fertility/fecundity0.66144609
156MP0010234_abnormal_vibrissa_follicle0.63798564
157MP0002160_abnormal_reproductive_system0.63540619
158MP0005376_homeostasis/metabolism_phenot0.61984144
159MP0003936_abnormal_reproductive_system0.60707404
160MP0005023_abnormal_wound_healing0.58521369
161MP0005220_abnormal_exocrine_pancreas0.57467909
162MP0005389_reproductive_system_phenotype0.55937703

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)5.53040207
2Hyperglycinuria (HP:0003108)4.91853914
3Intrahepatic cholestasis (HP:0001406)4.45677980
4Abnormality of glycine metabolism (HP:0010895)4.36554373
5Abnormality of serine family amino acid metabolism (HP:0010894)4.36554373
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.35260200
7Hypobetalipoproteinemia (HP:0003563)4.26651767
8Impulsivity (HP:0100710)4.17318264
9Pancreatic cysts (HP:0001737)4.01107373
10Ependymoma (HP:0002888)3.82771392
11Abnormality of pyrimidine metabolism (HP:0004353)3.82290256
12Pancreatic fibrosis (HP:0100732)3.79876863
13Breast hypoplasia (HP:0003187)3.70146184
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.63603729
15Xanthomatosis (HP:0000991)3.49905651
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.48565491
17Abnormality of alanine metabolism (HP:0010916)3.48565491
18Hyperalaninemia (HP:0003348)3.48565491
19Birth length less than 3rd percentile (HP:0003561)3.46773347
20Abnormality of serum amino acid levels (HP:0003112)3.44625767
21Hypolipoproteinemia (HP:0010981)3.41820334
22True hermaphroditism (HP:0010459)3.37286088
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.36629853
24Deep venous thrombosis (HP:0002625)3.36079266
25Molar tooth sign on MRI (HP:0002419)3.24364527
26Abnormality of midbrain morphology (HP:0002418)3.24364527
27Hyperammonemia (HP:0001987)3.10158100
28Congenital stationary night blindness (HP:0007642)3.09422732
29Abnormality of the labia minora (HP:0012880)3.08299936
30Nephronophthisis (HP:0000090)3.07740958
31Type II lissencephaly (HP:0007260)3.06170379
32Hypoalphalipoproteinemia (HP:0003233)3.03445848
33Abnormality of the lower motor neuron (HP:0002366)3.00900956
34Hypochromic microcytic anemia (HP:0004840)2.99477337
35Abnormality of methionine metabolism (HP:0010901)2.99046033
36Pendular nystagmus (HP:0012043)2.98799610
37Hyperlipoproteinemia (HP:0010980)2.96872931
38Complement deficiency (HP:0004431)2.95996459
39Abnormality of the renal cortex (HP:0011035)2.94062172
40Attenuation of retinal blood vessels (HP:0007843)2.93348844
41Carpal bone hypoplasia (HP:0001498)2.91892093
42Prolonged partial thromboplastin time (HP:0003645)2.90499860
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.89653475
44Abnormality of the renal collecting system (HP:0004742)2.88036387
45Duplicated collecting system (HP:0000081)2.82134026
46Gout (HP:0001997)2.79701159
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78043421
48Abnormality of DNA repair (HP:0003254)2.74939977
49Multiple enchondromatosis (HP:0005701)2.70844159
50Chromsome breakage (HP:0040012)2.70837011
51Abnormality of the renal medulla (HP:0100957)2.69195852
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.63624671
53Astrocytoma (HP:0009592)2.61141206
54Abnormality of the astrocytes (HP:0100707)2.61141206
55Rhabdomyosarcoma (HP:0002859)2.60392227
56Absent radius (HP:0003974)2.60056587
57Cerebellar dysplasia (HP:0007033)2.58033112
58Ureteral duplication (HP:0000073)2.54829636
59Fat malabsorption (HP:0002630)2.50496012
60Tetraplegia (HP:0002445)2.50149423
61Epidermoid cyst (HP:0200040)2.48897143
62Chronic hepatic failure (HP:0100626)2.46559278
63Renal cortical cysts (HP:0000803)2.44537846
64Azoospermia (HP:0000027)2.43313326
65Sclerocornea (HP:0000647)2.42257698
66Aplasia involving forearm bones (HP:0009822)2.39969131
67Absent forearm bone (HP:0003953)2.39969131
68Shawl scrotum (HP:0000049)2.38981194
69Premature ovarian failure (HP:0008209)2.37944347
70Abolished electroretinogram (ERG) (HP:0000550)2.37835890
71Homocystinuria (HP:0002156)2.37255271
72Abnormality of homocysteine metabolism (HP:0010919)2.37255271
73Abnormal spermatogenesis (HP:0008669)2.36453844
74Upper motor neuron abnormality (HP:0002127)2.34768302
75Abnormality of nucleobase metabolism (HP:0010932)2.34067442
76Glioma (HP:0009733)2.33500989
77Abnormality of the pons (HP:0007361)2.33080971
78Cystic liver disease (HP:0006706)2.32079056
79Patellar aplasia (HP:0006443)2.31500267
80Spastic diplegia (HP:0001264)2.31494894
81Facial hemangioma (HP:0000329)2.30025724
82Oral leukoplakia (HP:0002745)2.27926826
83Ectopic kidney (HP:0000086)2.27065242
84Megaloblastic anemia (HP:0001889)2.26177735
85Tubular atrophy (HP:0000092)2.24856338
86Medulloblastoma (HP:0002885)2.24354078
87Cerebral hypomyelination (HP:0006808)2.24112022
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.23608360
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22058236
90Rough bone trabeculation (HP:0100670)2.21106501
91Abnormality of the carotid arteries (HP:0005344)2.20255093
92Sloping forehead (HP:0000340)2.19623747
93Aplasia/Hypoplasia of the patella (HP:0006498)2.19571030
94Furrowed tongue (HP:0000221)2.18502807
95Clubbing of toes (HP:0100760)2.17842012
96Hypoplasia of the pons (HP:0012110)2.16735032
97Gaze-evoked nystagmus (HP:0000640)2.15848553
98Aplasia/hypoplasia of the humerus (HP:0006507)2.14132912
993-Methylglutaconic aciduria (HP:0003535)2.13836709
100Abnormality of the intrinsic pathway (HP:0010989)2.13156695
101Large for gestational age (HP:0001520)2.12864101
102Abnormality of complement system (HP:0005339)2.11209018
103Abnormal rod and cone electroretinograms (HP:0008323)2.09878783
104Methylmalonic acidemia (HP:0002912)2.08551408
105Medial flaring of the eyebrow (HP:0010747)2.07948651
106Increased CSF lactate (HP:0002490)2.04624726
107Chorioretinal atrophy (HP:0000533)2.03847322
108Aplasia/Hypoplasia of the tongue (HP:0010295)2.02790558
109Concave nail (HP:0001598)2.02766008
110Neoplasm of striated muscle (HP:0009728)2.02746149
111Abnormality of lateral ventricle (HP:0030047)2.02547900
112Anencephaly (HP:0002323)2.02140412
113Abnormal cartilage morphology (HP:0002763)2.01271364
114Lethargy (HP:0001254)2.00901956
115Lissencephaly (HP:0001339)2.00428249
116Progressive muscle weakness (HP:0003323)2.00379179
117Congenital, generalized hypertrichosis (HP:0004540)2.00321640
118Pseudobulbar signs (HP:0002200)2.00079338
119Irritability (HP:0000737)1.99899640
120Abnormality of chromosome stability (HP:0003220)1.99460697
121Hyperglycemia (HP:0003074)1.99191580
122Meckel diverticulum (HP:0002245)1.98436897
123Abnormality of macular pigmentation (HP:0008002)1.98411569
124Secondary amenorrhea (HP:0000869)1.98234806
125Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98160923
126Reticulocytopenia (HP:0001896)1.98144524
127Selective tooth agenesis (HP:0001592)1.97288145
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97112819
129Colon cancer (HP:0003003)1.96316230
130Increased serum lactate (HP:0002151)1.95596671
131Short humerus (HP:0005792)1.95558471
132Supernumerary spleens (HP:0009799)1.95124965
133Steatorrhea (HP:0002570)1.95006605
134Acute necrotizing encephalopathy (HP:0006965)1.94649764
135Male pseudohermaphroditism (HP:0000037)1.93359219
136Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92249243
137Increased corneal curvature (HP:0100692)1.91369746
138Keratoconus (HP:0000563)1.91369746
139Abnormality of the ileum (HP:0001549)1.89934240
140Abnormal biliary tract physiology (HP:0012439)1.87875559
141Bile duct proliferation (HP:0001408)1.87875559
142Neoplasm of the oral cavity (HP:0100649)1.87376090
143Postaxial foot polydactyly (HP:0001830)1.87213960
144Short thumb (HP:0009778)1.86844457
145Decreased central vision (HP:0007663)1.86258197
146Hyperventilation (HP:0002883)1.86137342
147Abnormal number of erythroid precursors (HP:0012131)1.84827014
148Ketosis (HP:0001946)1.84215433
149Small hand (HP:0200055)1.83586829
150Biliary tract neoplasm (HP:0100574)1.83457127
151Delayed puberty (HP:0000823)1.83050594
152Bony spicule pigmentary retinopathy (HP:0007737)1.82972371
153Abnormal drinking behavior (HP:0030082)1.82709870
154Polydipsia (HP:0001959)1.82709870
155Lipid accumulation in hepatocytes (HP:0006561)1.82473485
156Preaxial hand polydactyly (HP:0001177)1.82307856
157Absent thumb (HP:0009777)1.81980327
158Abnormality of the anterior horn cell (HP:0006802)1.81968539
159Degeneration of anterior horn cells (HP:0002398)1.81968539
160Abnormality of the preputium (HP:0100587)1.80552359
161Abnormality of the common coagulation pathway (HP:0010990)1.80132242
162Abnormal biliary tract morphology (HP:0012440)1.80107288
163Mitochondrial inheritance (HP:0001427)1.79949507
164Aplasia/Hypoplasia of the uvula (HP:0010293)1.79836916
165Agnosia (HP:0010524)1.78263765
166Duodenal stenosis (HP:0100867)1.77864144
167Small intestinal stenosis (HP:0012848)1.77864144
168Hyperuricemia (HP:0002149)1.77845800
169Increased purine levels (HP:0004368)1.77845800
170Hypoglycemic coma (HP:0001325)1.76507690
171Short tibia (HP:0005736)1.76143581
172Inability to walk (HP:0002540)1.76022972
173Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76000810
174Dicarboxylic aciduria (HP:0003215)1.76000810
175Acute encephalopathy (HP:0006846)1.75325891
176Dandy-Walker malformation (HP:0001305)1.74119654
177Severe muscular hypotonia (HP:0006829)1.72693483
178Astigmatism (HP:0000483)1.72309159
179Abnormal mitochondria in muscle tissue (HP:0008316)1.70802240
180Aplasia/hypoplasia of the uterus (HP:0008684)1.70654412
181Oligohydramnios (HP:0001562)1.67805048
182Progressive inability to walk (HP:0002505)1.67737367
183Triphalangeal thumb (HP:0001199)1.67614858
184Broad-based gait (HP:0002136)1.67526765
185Methylmalonic aciduria (HP:0012120)1.67455787
186Congenital hepatic fibrosis (HP:0002612)1.66726711
187Hypoplasia of the uterus (HP:0000013)1.66081906
188Progressive macrocephaly (HP:0004481)1.64848121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.93237645
2WEE14.42291642
3BUB14.19805636
4CDK124.05904297
5NEK22.94984972
6AKT32.89823161
7ADRBK22.89751204
8WNK42.87070890
9CDC72.86979658
10EPHA22.86846100
11TTK2.80771239
12BMPR1B2.54267115
13NEK12.52114824
14BCKDK2.51369276
15ACVR1B2.47267973
16NUAK12.33374073
17GRK12.25307855
18PLK12.16773587
19STK392.00456762
20STK38L1.94402950
21MAP4K21.91202978
22BRSK21.90188504
23LATS21.86729999
24LATS11.86599237
25TSSK61.81096684
26EIF2AK11.79623630
27CDK71.75057738
28TAOK31.68246651
29CDK41.67177120
30CHEK21.65312734
31PDK41.62627174
32PDK31.62627174
33INSRR1.60077202
34SRPK11.59255651
35PLK41.51278764
36OXSR11.51236499
37PNCK1.49800206
38DYRK31.47727473
39PLK31.39190392
40STK31.39009052
41MAPK131.34425630
42AURKB1.33604397
43CHEK11.27396057
44PBK1.23622451
45PDK21.20997552
46ATR1.17700829
47AURKA1.15882985
48MAP3K41.15832688
49MTOR1.12681592
50TRIM281.11885161
51VRK21.11070073
52ZAK1.11042534
53ERBB41.09798144
54EIF2AK31.09043885
55MST41.06777942
56RPS6KB21.05505852
57BRD41.04724755
58ICK1.04119459
59TAF11.02217348
60CAMKK21.00657013
61MKNK21.00421073
62BRSK10.99687321
63NTRK30.99344924
64CDK20.95385351
65MAP3K80.92753583
66ALK0.92565445
67NME20.90883342
68ADRBK10.89372448
69ATM0.87979916
70MELK0.87088528
71TLK10.86700393
72MAPK110.85339055
73MAPKAPK50.85128197
74RPS6KA50.85070339
75PIM10.84393351
76MUSK0.82338725
77CAMK1D0.81978927
78STK160.79379429
79MET0.79198881
80CDK60.77540862
81STK40.77377014
82PRKCI0.75926948
83FGFR40.73400547
84PAK30.72141319
85BRAF0.71850025
86CSNK1E0.71221719
87TGFBR10.71073417
88PLK20.69640643
89CDK10.68378500
90TYRO30.65983540
91TESK20.64760190
92PHKG10.63346098
93PHKG20.63346098
94IKBKB0.62799496
95NME10.62666200
96MKNK10.62009902
97TXK0.61891449
98CSNK2A20.61437049
99CSNK1G20.61373756
100PRKAA10.60900993
101PINK10.60513806
102CASK0.60417736
103CAMK1G0.60346250
104MAPKAPK30.60203737
105MAP3K30.58725265
106PRKCG0.57102905
107CDK80.56679331
108PRKCE0.56518355
109CSNK1A1L0.55584676
110FLT30.52871203
111AKT20.52039744
112PAK40.51823351
113PAK10.49648335
114CSNK1D0.49249168
115CSNK1G10.48787690
116MAP2K20.48419362
117CSNK2A10.46956895
118ERN10.46040833
119SCYL20.44379614
120TEC0.44377868
121STK100.42369816
122MAP2K60.42163836
123STK380.41469202
124CSNK1A10.40397402
125MAP2K70.39139518
126MAP2K10.37264063
127PKN10.36901352
128ABL20.35457379
129IRAK10.35348704
130MAP3K60.35114958
131RPS6KA40.34126248
132RPS6KB10.33369763
133PRKCQ0.33237351
134CAMK10.32493117
135SIK10.32270136
136MAPK10.31075536
137CSNK1G30.30676181
138VRK10.29766322
139GSK3B0.29422137
140PRKDC0.29219499
141DYRK20.28574440
142MAPK140.27735077
143MAPK100.27724663
144CCNB10.26953700
145MAP2K30.26293681
146TAOK20.25492468
147PASK0.25135404
148WNK30.24416504
149MAP3K50.24192263
150EIF2AK20.23898842

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.74577601
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00219936
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.82564456
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.75438625
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52120085
6Nitrogen metabolism_Homo sapiens_hsa009102.51102806
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39945209
8Phototransduction_Homo sapiens_hsa047442.30527116
9One carbon pool by folate_Homo sapiens_hsa006702.22891294
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.20745069
11RNA transport_Homo sapiens_hsa030132.16937114
12Folate biosynthesis_Homo sapiens_hsa007902.11726069
13Arginine biosynthesis_Homo sapiens_hsa002202.11271130
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07608789
15Mismatch repair_Homo sapiens_hsa034302.03263230
16RNA polymerase_Homo sapiens_hsa030202.02503569
17Selenocompound metabolism_Homo sapiens_hsa004501.97811306
18DNA replication_Homo sapiens_hsa030301.91361925
19Oxidative phosphorylation_Homo sapiens_hsa001901.90949864
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.90543277
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.85871971
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84233100
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.83375522
24Biosynthesis of amino acids_Homo sapiens_hsa012301.82711828
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78238435
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59288954
27Tryptophan metabolism_Homo sapiens_hsa003801.59180762
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58925367
29Parkinsons disease_Homo sapiens_hsa050121.55489843
30Protein export_Homo sapiens_hsa030601.55417490
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51997231
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50683952
33Complement and coagulation cascades_Homo sapiens_hsa046101.50494111
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49653610
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47070736
36Nicotine addiction_Homo sapiens_hsa050331.46625538
37Cell cycle_Homo sapiens_hsa041101.46014568
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39628032
39Fatty acid degradation_Homo sapiens_hsa000711.37144612
40Homologous recombination_Homo sapiens_hsa034401.35252415
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34779909
42Proteasome_Homo sapiens_hsa030501.33889423
43Spliceosome_Homo sapiens_hsa030401.33593082
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33527739
45Ether lipid metabolism_Homo sapiens_hsa005651.31624911
46Pentose phosphate pathway_Homo sapiens_hsa000301.31437565
47Carbon metabolism_Homo sapiens_hsa012001.30939914
48Nucleotide excision repair_Homo sapiens_hsa034201.30702360
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.28926287
50Pyrimidine metabolism_Homo sapiens_hsa002401.27370177
51Base excision repair_Homo sapiens_hsa034101.24137770
52Olfactory transduction_Homo sapiens_hsa047401.21046048
53Basal transcription factors_Homo sapiens_hsa030221.20062029
54Huntingtons disease_Homo sapiens_hsa050161.19300347
55Butanoate metabolism_Homo sapiens_hsa006501.18613550
56Vitamin digestion and absorption_Homo sapiens_hsa049771.18507284
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17260327
58Fat digestion and absorption_Homo sapiens_hsa049751.15890043
59Fanconi anemia pathway_Homo sapiens_hsa034601.12893371
60Sulfur relay system_Homo sapiens_hsa041221.12557436
61Taste transduction_Homo sapiens_hsa047421.09961059
62PPAR signaling pathway_Homo sapiens_hsa033201.09730667
63Peroxisome_Homo sapiens_hsa041461.09619015
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08605112
65beta-Alanine metabolism_Homo sapiens_hsa004101.08492512
66Propanoate metabolism_Homo sapiens_hsa006401.06957061
67Fatty acid metabolism_Homo sapiens_hsa012121.04778001
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02681595
69Chemical carcinogenesis_Homo sapiens_hsa052041.02248667
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01860509
71Retinol metabolism_Homo sapiens_hsa008300.99794528
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98618730
73Arginine and proline metabolism_Homo sapiens_hsa003300.94965571
74Fructose and mannose metabolism_Homo sapiens_hsa000510.94354342
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.93467751
76Morphine addiction_Homo sapiens_hsa050320.93157772
77mRNA surveillance pathway_Homo sapiens_hsa030150.93147138
78Caffeine metabolism_Homo sapiens_hsa002320.91014953
79Regulation of autophagy_Homo sapiens_hsa041400.86356123
80Lysine degradation_Homo sapiens_hsa003100.84675510
81Histidine metabolism_Homo sapiens_hsa003400.84096385
82p53 signaling pathway_Homo sapiens_hsa041150.82938362
83Glutathione metabolism_Homo sapiens_hsa004800.80893009
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80100723
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80084794
86Glycerolipid metabolism_Homo sapiens_hsa005610.79707213
87Pyruvate metabolism_Homo sapiens_hsa006200.79033315
88Alzheimers disease_Homo sapiens_hsa050100.78439625
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.76759677
90Phenylalanine metabolism_Homo sapiens_hsa003600.75150278
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.72790984
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71669253
93Sulfur metabolism_Homo sapiens_hsa009200.70069475
94Tyrosine metabolism_Homo sapiens_hsa003500.67962013
95RNA degradation_Homo sapiens_hsa030180.67075524
96Staphylococcus aureus infection_Homo sapiens_hsa051500.64056936
97Bile secretion_Homo sapiens_hsa049760.63440168
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63054613
99Steroid biosynthesis_Homo sapiens_hsa001000.63021713
100Starch and sucrose metabolism_Homo sapiens_hsa005000.62546452
101Fatty acid biosynthesis_Homo sapiens_hsa000610.62228705
102Cardiac muscle contraction_Homo sapiens_hsa042600.60629315
103Purine metabolism_Homo sapiens_hsa002300.57811713
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56923901
105Primary immunodeficiency_Homo sapiens_hsa053400.56657758
106Ovarian steroidogenesis_Homo sapiens_hsa049130.56019837
107Non-homologous end-joining_Homo sapiens_hsa034500.55408822
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54387875
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53781011
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53534803
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51420576
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.50745344
113Metabolic pathways_Homo sapiens_hsa011000.50737984
114Alcoholism_Homo sapiens_hsa050340.47661908
115ABC transporters_Homo sapiens_hsa020100.46224678
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46029393
117Collecting duct acid secretion_Homo sapiens_hsa049660.45657889
118Oocyte meiosis_Homo sapiens_hsa041140.45097600
119GABAergic synapse_Homo sapiens_hsa047270.44299672
120Systemic lupus erythematosus_Homo sapiens_hsa053220.43184055
121Galactose metabolism_Homo sapiens_hsa000520.42999209
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42134364
123Arachidonic acid metabolism_Homo sapiens_hsa005900.42108863
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41185757
125Ribosome_Homo sapiens_hsa030100.40840965
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40129000
127Serotonergic synapse_Homo sapiens_hsa047260.39989013
128Insulin secretion_Homo sapiens_hsa049110.39959894
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38563451
130Linoleic acid metabolism_Homo sapiens_hsa005910.37222977
131Fatty acid elongation_Homo sapiens_hsa000620.34373102
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33111027
133Glutamatergic synapse_Homo sapiens_hsa047240.32550363
134mTOR signaling pathway_Homo sapiens_hsa041500.32439023
135Epstein-Barr virus infection_Homo sapiens_hsa051690.29827300
136AMPK signaling pathway_Homo sapiens_hsa041520.25408686

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