ZXDB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The ZXDB gene is one of a pair of duplicated zinc finger genes on chromosome Xp11.21 (Greig et al., 1993 [PubMed 8268913]); see also ZXDA (MIM 300235). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.57050345
2urea cycle (GO:0000050)5.56339347
3urea metabolic process (GO:0019627)5.45880627
4nitrogen cycle metabolic process (GO:0071941)5.01380351
5embryonic process involved in female pregnancy (GO:0060136)4.60621460
6nuclear pore organization (GO:0006999)4.45628993
7midgut development (GO:0007494)4.12976048
8hepatocyte differentiation (GO:0070365)3.99111628
9mitotic sister chromatid cohesion (GO:0007064)3.96326155
10negative regulation of cell killing (GO:0031342)3.89673773
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.89673773
12negative regulation of protein activation cascade (GO:2000258)3.79765286
13histone H3-K36 demethylation (GO:0070544)3.79212955
14negative regulation of complement activation (GO:0045916)3.79014115
15pore complex assembly (GO:0046931)3.78634873
16regulation of RNA export from nucleus (GO:0046831)3.75033357
17synaptic vesicle maturation (GO:0016188)3.60554174
18response to laminar fluid shear stress (GO:0034616)3.58927928
19regulation of NFAT protein import into nucleus (GO:0051532)3.54151801
20negative regulation of fibrinolysis (GO:0051918)3.53928237
21genitalia morphogenesis (GO:0035112)3.50492652
22regulation of nucleobase-containing compound transport (GO:0032239)3.42612631
23regulation of fibrinolysis (GO:0051917)3.35148322
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.31312648
25regulation of synaptic vesicle exocytosis (GO:2000300)3.29079985
26regulation of protein activation cascade (GO:2000257)3.27969488
27locomotory exploration behavior (GO:0035641)3.26088167
28negative regulation of neurotransmitter secretion (GO:0046929)3.25653823
29phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.23169747
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22691383
31regulation of complement activation (GO:0030449)3.12045508
32regulation of histone H3-K27 methylation (GO:0061085)3.09916126
33ER overload response (GO:0006983)3.08237943
34desmosome organization (GO:0002934)3.06453304
35monoubiquitinated protein deubiquitination (GO:0035520)3.03143988
36stress granule assembly (GO:0034063)3.02305075
37nerve growth factor signaling pathway (GO:0038180)2.99922601
38COPII vesicle coating (GO:0048208)2.99403531
39protein localization to microtubule (GO:0035372)2.98913395
40negative regulation of humoral immune response (GO:0002921)2.98883681
41Golgi transport vesicle coating (GO:0048200)2.97808137
42COPI coating of Golgi vesicle (GO:0048205)2.97808137
43regulation of synaptic vesicle transport (GO:1902803)2.97338859
44cellular protein complex localization (GO:0034629)2.96126316
45activation of protein kinase A activity (GO:0034199)2.94039660
46layer formation in cerebral cortex (GO:0021819)2.93830634
47negative regulation of erythrocyte differentiation (GO:0045647)2.93169376
48homocysteine metabolic process (GO:0050667)2.91179934
49protein localization to endosome (GO:0036010)2.90177793
50protein targeting to Golgi (GO:0000042)2.89244253
51positive regulation of p38MAPK cascade (GO:1900745)2.88386324
52protein destabilization (GO:0031648)2.88328877
53regulation of ARF protein signal transduction (GO:0032012)2.87659112
54cytoplasmic mRNA processing body assembly (GO:0033962)2.86765490
55regulation of cholesterol homeostasis (GO:2000188)2.83551299
56regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.83453910
57fatty acid homeostasis (GO:0055089)2.82455876
58citrulline metabolic process (GO:0000052)2.82295536
59regulation of anoikis (GO:2000209)2.82070151
60positive regulation of macroautophagy (GO:0016239)2.81672988
61citrulline biosynthetic process (GO:0019240)2.80336993
62synaptic vesicle exocytosis (GO:0016079)2.79690201
63mating behavior (GO:0007617)2.79553049
64definitive hemopoiesis (GO:0060216)2.78358430
65mitotic chromosome condensation (GO:0007076)2.78180968
66regulation of p38MAPK cascade (GO:1900744)2.77775163
67negative regulation of fatty acid biosynthetic process (GO:0045717)2.77561748
68positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.76776650
69establishment of protein localization to Golgi (GO:0072600)2.75560210
70adenosine receptor signaling pathway (GO:0001973)2.74087530
71positive regulation of Rap GTPase activity (GO:0032854)2.73433763
72activation of Rac GTPase activity (GO:0032863)2.70918421
73retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63919795
74dicarboxylic acid biosynthetic process (GO:0043650)2.63293478
75regulation of glucose import in response to insulin stimulus (GO:2001273)2.61291286
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60656224
77regulation of glucocorticoid metabolic process (GO:0031943)2.60153010
78histone lysine demethylation (GO:0070076)2.60103317
79regulation of Rap GTPase activity (GO:0032317)2.59923232
80positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.59007187
81cell-substrate adherens junction assembly (GO:0007045)2.58962790
82focal adhesion assembly (GO:0048041)2.58962790
83DNA synthesis involved in DNA repair (GO:0000731)2.57674547
84response to growth hormone (GO:0060416)2.57669348
85embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56592235
86histone demethylation (GO:0016577)2.54755778
87histone H3-K9 demethylation (GO:0033169)2.54407345
88regulation of transforming growth factor beta2 production (GO:0032909)2.51981635
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51256535
90establishment of endothelial barrier (GO:0061028)2.50952622
91cellular response to ethanol (GO:0071361)2.50939499
92negative regulation of immunoglobulin mediated immune response (GO:0002890)2.49455379
93negative regulation of B cell mediated immunity (GO:0002713)2.49455379
94insulin secretion (GO:0030073)2.44926373
95lipid translocation (GO:0034204)2.42813733
96phospholipid translocation (GO:0045332)2.42813733
97response to interleukin-15 (GO:0070672)2.42675894
98embryonic camera-type eye morphogenesis (GO:0048596)2.40554809
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.39408695
100regulation of Rac protein signal transduction (GO:0035020)2.39120923
101cell adhesion mediated by integrin (GO:0033627)2.38812911
102pericardium development (GO:0060039)2.37574122
103adherens junction assembly (GO:0034333)2.37327174
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.36072168
105L-phenylalanine metabolic process (GO:0006558)2.36072168
106positive regulation of gamma-delta T cell activation (GO:0046645)2.36043402
107cerebellar Purkinje cell differentiation (GO:0021702)2.35940103
108intestinal cholesterol absorption (GO:0030299)2.35645000
109body morphogenesis (GO:0010171)2.35461432
110glutamate secretion (GO:0014047)2.34320658
111protein carboxylation (GO:0018214)2.34024103
112peptidyl-glutamic acid carboxylation (GO:0017187)2.34024103
113regulation of steroid hormone biosynthetic process (GO:0090030)2.33250382
114cellular response to antibiotic (GO:0071236)2.33232061
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.32652836
116regulation of transforming growth factor beta1 production (GO:0032908)2.32641345
117pathway-restricted SMAD protein phosphorylation (GO:0060389)2.32597449
118signal complex assembly (GO:0007172)2.32433075
119glycogen catabolic process (GO:0005980)2.31395925
120regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31036679
121negative T cell selection (GO:0043383)2.30844833
122fibrinolysis (GO:0042730)2.30731311
123phosphatidylinositol phosphorylation (GO:0046854)2.30506184
124exploration behavior (GO:0035640)2.29818528
125nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.29592540
126dosage compensation (GO:0007549)2.28675492
127negative thymic T cell selection (GO:0045060)2.28180279
128negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.28115485
129positive T cell selection (GO:0043368)2.28049834
130iron ion import (GO:0097286)2.28034932
131negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.27781692
132potassium ion import (GO:0010107)2.27664655
133regulation of centriole replication (GO:0046599)2.27579893
134macroautophagy (GO:0016236)2.27290004
135protein demethylation (GO:0006482)2.25495415
136protein dealkylation (GO:0008214)2.25495415
137Rap protein signal transduction (GO:0032486)2.23602993
1383-UTR-mediated mRNA stabilization (GO:0070935)2.23256350
139response to dexamethasone (GO:0071548)2.23155538
140vesicle transport along microtubule (GO:0047496)2.22546831
141regulation of neuronal synaptic plasticity (GO:0048168)2.22378965
142regulation of glutamate receptor signaling pathway (GO:1900449)2.22214651
143insulin-like growth factor receptor signaling pathway (GO:0048009)2.21932056
144neuron cell-cell adhesion (GO:0007158)2.21389485
145positive thymic T cell selection (GO:0045059)2.19944433
146retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.19659224
147cellular potassium ion homeostasis (GO:0030007)2.18868751
148negative regulation of norepinephrine secretion (GO:0010700)2.18822624
149growth hormone receptor signaling pathway (GO:0060396)2.18729472
150long-term synaptic potentiation (GO:0060291)2.18524906
151regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.17982030
152JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.17943446
153dendrite morphogenesis (GO:0048813)2.16141471
154regulation of beta-amyloid formation (GO:1902003)2.15793000
155clathrin coat assembly (GO:0048268)2.15341443
156negative regulation of catecholamine secretion (GO:0033604)2.14697742
157cerebellar Purkinje cell layer development (GO:0021680)2.13979987
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.12757330
159positive regulation of muscle hypertrophy (GO:0014742)2.12207486
160positive regulation of cardiac muscle hypertrophy (GO:0010613)2.12207486
161type B pancreatic cell development (GO:0003323)2.12109297
162cellular response to interleukin-15 (GO:0071350)2.10129776
163exocrine pancreas development (GO:0031017)2.09687923
164regulation of synaptic transmission, GABAergic (GO:0032228)2.09556218
165positive regulation of vesicle fusion (GO:0031340)2.08854152
166regulation of gamma-delta T cell differentiation (GO:0045586)2.07757904
167regulation of synapse structural plasticity (GO:0051823)2.07291457
168lymph vessel development (GO:0001945)2.06658790
169lipid phosphorylation (GO:0046834)2.06625412
170SMAD protein complex assembly (GO:0007183)2.06553235
171detection of calcium ion (GO:0005513)2.06141007
172protein localization to Golgi apparatus (GO:0034067)2.05707782
173regulation of interleukin-12 biosynthetic process (GO:0045075)2.05180683
174cellular response to glucagon stimulus (GO:0071377)2.04983947
175positive regulation of synaptic transmission, GABAergic (GO:0032230)2.04772206
176cytoskeletal anchoring at plasma membrane (GO:0007016)2.04700111
177long-term memory (GO:0007616)2.03700148
178suckling behavior (GO:0001967)2.03684322
179peptidyl-tyrosine autophosphorylation (GO:0038083)2.03370645
180neurotransmitter secretion (GO:0007269)2.02025765
181regulation of vesicle fusion (GO:0031338)2.01575056
182T cell selection (GO:0045058)2.01457014
183regulation of B cell receptor signaling pathway (GO:0050855)2.01414938
184positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.01017758
185vesicle coating (GO:0006901)1.99724091
186ionotropic glutamate receptor signaling pathway (GO:0035235)1.99387678
187cAMP biosynthetic process (GO:0006171)1.97401277
188cellular extravasation (GO:0045123)1.97153896
189thymic T cell selection (GO:0045061)1.96931991
190presynaptic membrane assembly (GO:0097105)1.96885014
191regulation of amyloid precursor protein catabolic process (GO:1902991)1.96800937
192adaptation of signaling pathway (GO:0023058)1.96306748
193interleukin-1-mediated signaling pathway (GO:0070498)1.96231289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.55659417
2ZNF263_19887448_ChIP-Seq_K562_Human3.39301304
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11950737
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03544984
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.96841711
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.80408462
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69271690
8E2F7_22180533_ChIP-Seq_HELA_Human2.67405189
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.61692251
10MYC_22102868_ChIP-Seq_BL_Human2.58418709
11PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.45360393
12EZH2_22144423_ChIP-Seq_EOC_Human2.37583687
13CLOCK_20551151_ChIP-Seq_293T_Human2.34655664
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18872357
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14814599
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.08469220
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07948757
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.97864924
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.97864924
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95193994
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89981626
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88078171
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87978721
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86473372
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86119389
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84867026
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.81864609
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79561689
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79432225
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76732326
31GBX2_23144817_ChIP-Seq_PC3_Human1.76135688
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73106398
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72716221
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71775816
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71000360
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69444737
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69380413
38TFEB_21752829_ChIP-Seq_HELA_Human1.69215765
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67859774
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67663566
41FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.67389834
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66397533
43RUNX_20019798_ChIP-Seq_JUKART_Human1.66125051
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.65743436
45GATA1_22025678_ChIP-Seq_K562_Human1.64748074
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64358715
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63869259
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63403491
49AR_21909140_ChIP-Seq_LNCAP_Human1.63244936
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60822286
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.60251451
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.59442519
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58812335
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56612389
55ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.56392894
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55935644
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.55465973
58IGF1R_20145208_ChIP-Seq_DFB_Human1.54106094
59DROSHA_22980978_ChIP-Seq_HELA_Human1.52895301
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52405715
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.52043217
62TAF15_26573619_Chip-Seq_HEK293_Human1.51495525
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49030382
64EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49030382
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48542803
66TP53_16413492_ChIP-PET_HCT116_Human1.48357001
67CHD1_26751641_Chip-Seq_LNCaP_Human1.47516300
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.46677907
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46337937
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45689677
71AR_21572438_ChIP-Seq_LNCaP_Human1.44440222
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41992736
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41809730
74ATF3_27146783_Chip-Seq_COLON_Human1.40613680
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39478067
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39415551
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.39195326
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.39149518
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38932909
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36383646
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35354219
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33302758
83SMAD4_21799915_ChIP-Seq_A2780_Human1.32895900
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.32164860
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.31802124
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31649374
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30708040
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30374042
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30359412
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28991605
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28873942
92RXR_22108803_ChIP-Seq_LS180_Human1.28771257
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28607333
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28196118
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.27502792
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.27120409
97AHR_22903824_ChIP-Seq_MCF-7_Human1.27078882
98PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26298945
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25269194
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.25005565
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.25002468
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.24996402
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24904420
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23173075
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23028853
106BCAT_22108803_ChIP-Seq_LS180_Human1.22047467
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21584802
108P300_19829295_ChIP-Seq_ESCs_Human1.20695254
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18915139
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17172262
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15929001
112MAF_26560356_Chip-Seq_TH1_Human1.15404346
113STAT3_23295773_ChIP-Seq_U87_Human1.15129182
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14827968
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14715375
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14715375
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.14172359
118MYB_26560356_Chip-Seq_TH2_Human1.13267764
119VDR_24787735_ChIP-Seq_THP-1_Human1.12813950
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12663204
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11981380
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11456851
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10469672
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.09913819
125EGR1_19374776_ChIP-ChIP_THP-1_Human1.09216591
126REST_21632747_ChIP-Seq_MESCs_Mouse1.09167345
127GATA6_25053715_ChIP-Seq_YYC3_Human1.09083615
128MYB_26560356_Chip-Seq_TH1_Human1.08552407
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08481584
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.08115590
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.07632872
132ZNF274_21170338_ChIP-Seq_K562_Hela1.07207227
133FOXA2_19822575_ChIP-Seq_HepG2_Human1.07103317
134BRD4_25478319_ChIP-Seq_HGPS_Human1.06812453
135ELK3_25401928_ChIP-Seq_HUVEC_Human1.06118125
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06061986
137VDR_21846776_ChIP-Seq_THP-1_Human1.05677301
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05328725
139IRF8_27001747_Chip-Seq_BMDM_Mouse1.04921020
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04645097
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04510052
142RACK7_27058665_Chip-Seq_MCF-7_Human1.04308182
143TP53_18474530_ChIP-ChIP_U2OS_Human1.04190484
144SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03341879
145FOXO3_23340844_ChIP-Seq_DLD1_Human1.03242875
146KDM2B_26808549_Chip-Seq_K562_Human1.02651097
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02399134
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02005084
149TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01543109
150CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01435518
151KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00293475
152GATA2_21666600_ChIP-Seq_HMVEC_Human0.99651960
153IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99271729
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98794488
155AR_25329375_ChIP-Seq_VCAP_Human0.98552373
156AR_19668381_ChIP-Seq_PC3_Human0.98057006
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98042294
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.97902107
159TCF4_18268006_ChIP-ChIP_LS174T_Human0.97518381
160Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97408741
161TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97284630
162MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97024556
163NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96298055
164TBX20_22328084_ChIP-Seq_HEART_Mouse0.96117843
165TBX20_22080862_ChIP-Seq_HEART_Mouse0.96117843
166MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95709059
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95245451
168TCF7_22412390_ChIP-Seq_EML_Mouse0.94667776
169SPI1_23127762_ChIP-Seq_K562_Human0.94191623
170E2F1_21310950_ChIP-Seq_MCF-7_Human0.94086915
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93007246
172KDM2B_26808549_Chip-Seq_DND41_Human0.92837077
173KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92509353
174RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91450014
175YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91425845
176BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91374431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.56834111
2MP0008057_abnormal_DNA_replication3.25042778
3MP0004859_abnormal_synaptic_plasticity3.24675072
4MP0009780_abnormal_chondrocyte_physiolo3.18126344
5MP0010234_abnormal_vibrissa_follicle3.08702416
6MP0002877_abnormal_melanocyte_morpholog2.89462903
7MP0000013_abnormal_adipose_tissue2.64331065
8MP0004233_abnormal_muscle_weight2.57517934
9MP0003880_abnormal_central_pattern2.47359744
10MP0002909_abnormal_adrenal_gland2.33358606
11MP0003635_abnormal_synaptic_transmissio2.25173063
12MP0003787_abnormal_imprinting2.21067303
13MP0004808_abnormal_hematopoietic_stem2.19698363
14MP0000569_abnormal_digit_pigmentation2.19554314
15MP0003283_abnormal_digestive_organ2.18299577
16MP0003705_abnormal_hypodermis_morpholog2.11970597
17MP0002139_abnormal_hepatobiliary_system2.06805397
18MP0009697_abnormal_copulation2.05310916
19MP0002693_abnormal_pancreas_physiology2.05014277
20MP0004510_myositis2.00798730
21MP0003303_peritoneal_inflammation1.95962238
22MP0003566_abnormal_cell_adhesion1.87012337
23MP0005623_abnormal_meninges_morphology1.85066652
24MP0003045_fibrosis1.83862955
25MP0004270_analgesia1.80902928
26MP0003122_maternal_imprinting1.78834989
27MP0004185_abnormal_adipocyte_glucose1.78362032
28MP0002166_altered_tumor_susceptibility1.76732025
29MP0009745_abnormal_behavioral_response1.70698480
30MP0002138_abnormal_hepatobiliary_system1.70112257
31MP0002063_abnormal_learning/memory/cond1.69980957
32MP0001879_abnormal_lymphatic_vessel1.67290669
33MP0003453_abnormal_keratinocyte_physiol1.66895468
34MP0001944_abnormal_pancreas_morphology1.65022172
35MP0001915_intracranial_hemorrhage1.62773045
36MP0003172_abnormal_lysosome_physiology1.62051562
37MP0008961_abnormal_basal_metabolism1.61698348
38MP0002822_catalepsy1.58968385
39MP0002009_preneoplasia1.58889954
40MP0003183_abnormal_peptide_metabolism1.54681520
41MP0010386_abnormal_urinary_bladder1.54585574
42MP0001501_abnormal_sleep_pattern1.50963665
43MP0002396_abnormal_hematopoietic_system1.49937660
44MP0001851_eye_inflammation1.47034307
45MP0005083_abnormal_biliary_tract1.46889252
46MP0005085_abnormal_gallbladder_physiolo1.43467322
47MP0002064_seizures1.42607410
48MP0005375_adipose_tissue_phenotype1.39486030
49MP0000733_abnormal_muscle_development1.39326133
50MP0004130_abnormal_muscle_cell1.35110909
51MP0006054_spinal_hemorrhage1.34696717
52MP0003656_abnormal_erythrocyte_physiolo1.33483710
53MP0005379_endocrine/exocrine_gland_phen1.33376104
54MP0000003_abnormal_adipose_tissue1.33090472
55MP0002928_abnormal_bile_duct1.32693195
56MP0003828_pulmonary_edema1.32668734
57MP0002572_abnormal_emotion/affect_behav1.31827086
58MP0005310_abnormal_salivary_gland1.31812729
59MP0009840_abnormal_foam_cell1.30757346
60MP0008569_lethality_at_weaning1.29752658
61MP0002086_abnormal_extraembryonic_tissu1.28943849
62MP0003866_abnormal_defecation1.26386644
63MP0005167_abnormal_blood-brain_barrier1.24374713
64MP0003191_abnormal_cellular_cholesterol1.23015688
65MP0003950_abnormal_plasma_membrane1.20933579
66MP0005666_abnormal_adipose_tissue1.20458511
67MP0003984_embryonic_growth_retardation1.20344298
68MP0005365_abnormal_bile_salt1.19523812
69MP0002971_abnormal_brown_adipose1.19502957
70MP0003252_abnormal_bile_duct1.19500202
71MP0005621_abnormal_cell_physiology1.18993338
72MP0003123_paternal_imprinting1.18380494
73MP0002006_tumorigenesis1.18094481
74MP0002796_impaired_skin_barrier1.18002800
75MP0002088_abnormal_embryonic_growth/wei1.16282866
76MP0005451_abnormal_body_composition1.16236490
77MP0004957_abnormal_blastocyst_morpholog1.15958248
78MP0001666_abnormal_nutrient_absorption1.15682177
79MP0010352_gastrointestinal_tract_polyps1.15449093
80MP0005671_abnormal_response_to1.13847908
81MP0001661_extended_life_span1.12892040
82MP0005535_abnormal_body_temperature1.12049111
83MP0005023_abnormal_wound_healing1.11860624
84MP0010307_abnormal_tumor_latency1.11219706
85MP0000609_abnormal_liver_physiology1.09653031
86MP0005647_abnormal_sex_gland1.09343249
87MP0003091_abnormal_cell_migration1.07283695
88MP0001835_abnormal_antigen_presentation1.07160023
89MP0003633_abnormal_nervous_system1.06851056
90MP0003943_abnormal_hepatobiliary_system1.05183104
91MP0002272_abnormal_nervous_system1.05083620
92MP0005501_abnormal_skin_physiology1.04384856
93MP0001730_embryonic_growth_arrest1.04061085
94MP0001790_abnormal_immune_system1.03637502
95MP0005387_immune_system_phenotype1.03637502
96MP0001672_abnormal_embryogenesis/_devel1.03481310
97MP0005380_embryogenesis_phenotype1.03481310
98MP0000350_abnormal_cell_proliferation1.02979719
99MP0001765_abnormal_ion_homeostasis1.02953780
100MP0001486_abnormal_startle_reflex1.02865844
101MP0001177_atelectasis1.02744769
102MP0005187_abnormal_penis_morphology1.01489270
103MP0005409_darkened_coat_color1.01334544
104MP0009384_cardiac_valve_regurgitation0.99596876
105MP0005220_abnormal_exocrine_pancreas0.98860960
106MP0005058_abnormal_lysosome_morphology0.98233639
107MP0001216_abnormal_epidermal_layer0.98176709
108MP0002733_abnormal_thermal_nociception0.98089910
109MP0003077_abnormal_cell_cycle0.97168430
110MP0010368_abnormal_lymphatic_system0.97042910
111MP0001188_hyperpigmentation0.96129840
112MP0009115_abnormal_fat_cell0.94599473
113MP0003075_altered_response_to0.93087708
114MP0010678_abnormal_skin_adnexa0.91709621
115MP0001970_abnormal_pain_threshold0.91690752
116MP0002332_abnormal_exercise_endurance0.90641024
117MP0005000_abnormal_immune_tolerance0.90498324
118MP0002060_abnormal_skin_morphology0.90119981
119MP0001502_abnormal_circadian_rhythm0.88053922
120MP0003868_abnormal_feces_composition0.87343302
121MP0000598_abnormal_liver_morphology0.86954652
122MP0010630_abnormal_cardiac_muscle0.86762600
123MP0001853_heart_inflammation0.86087197
124MP0000465_gastrointestinal_hemorrhage0.85677890
125MP0002998_abnormal_bone_remodeling0.85605879
126MP0005386_behavior/neurological_phenoty0.85505608
127MP0004924_abnormal_behavior0.85505608
128MP0002734_abnormal_mechanical_nocicepti0.84940153
129MP0000703_abnormal_thymus_morphology0.84167311
130MP0002078_abnormal_glucose_homeostasis0.83335658
131MP0001968_abnormal_touch/_nociception0.83107762
132MP0002896_abnormal_bone_mineralization0.83064755
133MP0005646_abnormal_pituitary_gland0.82639606
134MP0005076_abnormal_cell_differentiation0.82366339
135MP0003690_abnormal_glial_cell0.82045126
136MP0001348_abnormal_lacrimal_gland0.82019572
137MP0000613_abnormal_salivary_gland0.81428974
138MP0003763_abnormal_thymus_physiology0.80796741
139MP0009672_abnormal_birth_weight0.80707098
140MP0004043_abnormal_pH_regulation0.80003602
141MP0003959_abnormal_lean_body0.79867950
142MP0004197_abnormal_fetal_growth/weight/0.79323177
143MP0005384_cellular_phenotype0.79045069
144MP0005464_abnormal_platelet_physiology0.78337785
145MP0001800_abnormal_humoral_immune0.78279412
146MP0003329_amyloid_beta_deposits0.78154754
147MP0009046_muscle_twitch0.77983045
148MP0003121_genomic_imprinting0.77832182
149MP0000685_abnormal_immune_system0.77785435
150MP0005645_abnormal_hypothalamus_physiol0.77713876
151MP0000377_abnormal_hair_follicle0.75466648
152MP0004272_abnormal_basement_membrane0.75410184
153MP0005334_abnormal_fat_pad0.75052331
154MP0004811_abnormal_neuron_physiology0.74921528
155MP0002168_other_aberrant_phenotype0.74651036
156MP0002420_abnormal_adaptive_immunity0.74279816
157MP0004264_abnormal_extraembryonic_tissu0.74075084
158MP0008058_abnormal_DNA_repair0.74072106
159MP0002557_abnormal_social/conspecific_i0.73802641
160MP0004947_skin_inflammation0.73723008
161MP0003941_abnormal_skin_development0.73450619
162MP0009703_decreased_birth_body0.73266331
163MP0001819_abnormal_immune_cell0.73236936
164MP0010155_abnormal_intestine_physiology0.73195561
165MP0002163_abnormal_gland_morphology0.72999892
166MP0003890_abnormal_embryonic-extraembry0.72477683
167MP0000920_abnormal_myelination0.72331884
168MP0002080_prenatal_lethality0.72033360
169MP0004087_abnormal_muscle_fiber0.71547380
170MP0001873_stomach_inflammation0.71228994
171MP0002697_abnormal_eye_size0.70040235
172MP0001849_ear_inflammation0.69878546
173MP0003221_abnormal_cardiomyocyte_apopto0.69427723
174MP0001340_abnormal_eyelid_morphology0.69349218
175MP0009931_abnormal_skin_appearance0.69185587
176MP0001697_abnormal_embryo_size0.68255023

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)4.22037098
2Papilledema (HP:0001085)4.21641996
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.10323103
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.80992021
5Deep venous thrombosis (HP:0002625)3.47033892
6Papillary thyroid carcinoma (HP:0002895)3.41651156
7Neonatal hypoglycemia (HP:0001998)3.36619298
8Visual hallucinations (HP:0002367)3.32923996
9Asymmetry of the thorax (HP:0001555)3.20015996
10Abnormality of the nasal septum (HP:0000419)3.19134407
11Hypobetalipoproteinemia (HP:0003563)3.10774881
12Focal motor seizures (HP:0011153)3.10113824
13Spinal cord lesions (HP:0100561)2.96571635
14Syringomyelia (HP:0003396)2.96571635
15Dysmetric saccades (HP:0000641)2.96570855
16Hypoglycemic seizures (HP:0002173)2.94366926
17Decreased circulating renin level (HP:0003351)2.81236283
18Deep philtrum (HP:0002002)2.79461581
19Hyperinsulinemic hypoglycemia (HP:0000825)2.78755888
20Symptomatic seizures (HP:0011145)2.74796367
21Abnormality of endocrine pancreas physiology (HP:0012093)2.73528727
22Abnormality of the pancreatic islet cells (HP:0006476)2.73528727
23Focal seizures (HP:0007359)2.72911645
24Atonic seizures (HP:0010819)2.71399505
25Pancreatic islet-cell hyperplasia (HP:0004510)2.70347937
26Abnormality of the common coagulation pathway (HP:0010990)2.68139102
27Conjugated hyperbilirubinemia (HP:0002908)2.67384037
28Heterotopia (HP:0002282)2.66614771
29Relative macrocephaly (HP:0004482)2.63387287
30Dysostosis multiplex (HP:0000943)2.59392930
31Arterial tortuosity (HP:0005116)2.54998842
32Prolonged partial thromboplastin time (HP:0003645)2.50741628
33Sparse lateral eyebrow (HP:0005338)2.49394206
34Abnormality of the intrinsic pathway (HP:0010989)2.44722623
35Truncal ataxia (HP:0002078)2.44584021
36Fair hair (HP:0002286)2.43997199
37Lip pit (HP:0100267)2.38687331
38Termporal pattern (HP:0011008)2.38685329
39Insidious onset (HP:0003587)2.38685329
40Flat acetabular roof (HP:0003180)2.38516087
41Hematochezia (HP:0002573)2.37191646
42Mucopolysacchariduria (HP:0008155)2.36123730
43Urinary glycosaminoglycan excretion (HP:0003541)2.36123730
44Volvulus (HP:0002580)2.35936544
45Agitation (HP:0000713)2.35515467
46Abnormality of the left ventricular outflow tract (HP:0011103)2.35016437
47Subaortic stenosis (HP:0001682)2.35016437
48Viral hepatitis (HP:0006562)2.27129616
49Absence seizures (HP:0002121)2.25987440
50Abnormality of calcium-phosphate metabolism (HP:0100530)2.25896951
51Vascular tortuosity (HP:0004948)2.25553991
52Micronodular cirrhosis (HP:0001413)2.24678048
53Overgrowth (HP:0001548)2.20516437
54Vascular calcification (HP:0004934)2.20415697
55Deep palmar crease (HP:0006191)2.17127640
56Depression (HP:0000716)2.16191034
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14668985
58Abnormality of polysaccharide metabolism (HP:0011012)2.14668985
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14668985
60Supranuclear gaze palsy (HP:0000605)2.14147057
61Action tremor (HP:0002345)2.13689198
62Abnormal pancreas size (HP:0012094)2.10169479
63Blue irides (HP:0000635)2.09798151
64Broad face (HP:0000283)2.09190757
65Thyroid carcinoma (HP:0002890)2.08443142
66Curly hair (HP:0002212)2.05703395
67Cardiovascular calcification (HP:0011915)2.04778340
68Menstrual irregularities (HP:0000858)2.04217225
69Hepatitis (HP:0012115)2.03443580
70Thoracolumbar scoliosis (HP:0002944)2.02347542
71Dialeptic seizures (HP:0011146)2.01614553
72Milia (HP:0001056)2.01538957
73Mitral stenosis (HP:0001718)2.00832976
74Buphthalmos (HP:0000557)2.00782522
75Hypercortisolism (HP:0001578)2.00565630
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00537573
77Abnormality of oral frenula (HP:0000190)2.00063394
78Striae distensae (HP:0001065)1.99881973
79Epileptic encephalopathy (HP:0200134)1.98729670
80Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97923299
81Cerebral aneurysm (HP:0004944)1.97652256
82Increased CSF protein (HP:0002922)1.96633403
83Impaired smooth pursuit (HP:0007772)1.96622212
84Subacute progressive viral hepatitis (HP:0006572)1.96090371
85Generalized tonic-clonic seizures (HP:0002069)1.95200594
86Ankyloglossia (HP:0010296)1.94647906
87Submucous cleft hard palate (HP:0000176)1.92576862
88Epileptiform EEG discharges (HP:0011182)1.92175576
89Slow saccadic eye movements (HP:0000514)1.91915682
90Abnormal delayed hypersensitivity skin test (HP:0002963)1.91757580
91Overlapping toe (HP:0001845)1.91331477
92Inappropriate behavior (HP:0000719)1.90848878
93EEG with generalized epileptiform discharges (HP:0011198)1.90660170
94Exotropia (HP:0000577)1.87838493
95Abnormality of the right ventricle (HP:0001707)1.87528245
96Thickened calvaria (HP:0002684)1.87377652
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87290535
98Missing ribs (HP:0000921)1.86393827
99Megalencephaly (HP:0001355)1.86375426
100Hydroureter (HP:0000072)1.86060404
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.85756209
102Osteolytic defects of the hand bones (HP:0009699)1.85756209
103Hypsarrhythmia (HP:0002521)1.85734516
104Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85325335
105Low anterior hairline (HP:0000294)1.85123993
106Hamartoma (HP:0010566)1.84787465
107Insulin-resistant diabetes mellitus (HP:0000831)1.84110672
108Spontaneous hematomas (HP:0007420)1.83840435
109Excessive salivation (HP:0003781)1.83632176
110Drooling (HP:0002307)1.83632176
111Acute myeloid leukemia (HP:0004808)1.82864350
112Elbow flexion contracture (HP:0002987)1.82112478
113Resting tremor (HP:0002322)1.81195677
114Ankle clonus (HP:0011448)1.81022475
115T lymphocytopenia (HP:0005403)1.80903022
116Aortic aneurysm (HP:0004942)1.80893579
117Distal lower limb amyotrophy (HP:0008944)1.79716706
118Aqueductal stenosis (HP:0002410)1.79251625
119Increased circulating renin level (HP:0000848)1.79048482
120Growth hormone excess (HP:0000845)1.78246524
121Urinary bladder sphincter dysfunction (HP:0002839)1.77280874
122Abnormality of T cell number (HP:0011839)1.77253372
123Vertebral compression fractures (HP:0002953)1.77110089
124Testicular neoplasm (HP:0010788)1.77003220
125Impaired vibration sensation in the lower limbs (HP:0002166)1.76329206
126Abnormality of the Achilles tendon (HP:0005109)1.75949963
127Genetic anticipation (HP:0003743)1.75160767
128Hyperkalemia (HP:0002153)1.74678997
129Stereotypic behavior (HP:0000733)1.73121069
130Abnormality of salivation (HP:0100755)1.72877377
131Abnormality of the gastric mucosa (HP:0004295)1.72211956
132Hyperglycemia (HP:0003074)1.72140683
133Deviation of the thumb (HP:0009603)1.71935692
134Abnormality of the periventricular white matter (HP:0002518)1.71025775
135Prominent nose (HP:0000448)1.70607033
136Scanning speech (HP:0002168)1.70600787
137Bicuspid aortic valve (HP:0001647)1.70527412
138Fatigue (HP:0012378)1.69970577
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69921890
140Hemiplegia (HP:0002301)1.69568404
141Cubitus valgus (HP:0002967)1.69317015
142Open mouth (HP:0000194)1.68762050
143Hypolipoproteinemia (HP:0010981)1.68594061
144Enlarged penis (HP:0000040)1.68294652
145Spondylolisthesis (HP:0003302)1.67849704
146Thick eyebrow (HP:0000574)1.67224633
147Truncal obesity (HP:0001956)1.66977121
148Congenital glaucoma (HP:0001087)1.66827042
149Coarse hair (HP:0002208)1.65582702
150Long palpebral fissure (HP:0000637)1.65532082
151Hyperparathyroidism (HP:0000843)1.65476537
152Autoamputation (HP:0001218)1.65472246
153Generalized hypopigmentation of hair (HP:0011358)1.65011495
154Increased cerebral lipofuscin (HP:0011813)1.64914021
155Hypokalemic alkalosis (HP:0001949)1.64658025
156Poor eye contact (HP:0000817)1.64644969
157Abnormality of pyrimidine metabolism (HP:0004353)1.63535441
158Joint hemorrhage (HP:0005261)1.63343379
159Widely spaced teeth (HP:0000687)1.63276041
160Anxiety (HP:0000739)1.63216504
161Narrow palate (HP:0000189)1.63160759
162Achilles tendon contracture (HP:0001771)1.62779168
163Hyperactive renin-angiotensin system (HP:0000841)1.62754070
164Leiomyosarcoma (HP:0100243)1.62323366
165Uterine leiomyosarcoma (HP:0002891)1.62323366
166Abnormality of renin-angiotensin system (HP:0000847)1.62278591
167Cerebral inclusion bodies (HP:0100314)1.61820752
168Abnormal social behavior (HP:0012433)1.61555343
169Impaired social interactions (HP:0000735)1.61555343
170Impaired pain sensation (HP:0007328)1.58725566
171Abnormality of pain sensation (HP:0010832)1.58725566
172Spinal canal stenosis (HP:0003416)1.58253822
173Exocrine pancreatic insufficiency (HP:0001738)1.57773465
174Germ cell neoplasia (HP:0100728)1.57004049
175Cystic hygroma (HP:0000476)1.56950557
176Mitral valve prolapse (HP:0001634)1.53767843
177Broad nasal tip (HP:0000455)1.53116252
178Long eyelashes (HP:0000527)1.52482522
179Hypercholesterolemia (HP:0003124)1.52293169
180Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.51084811
181Dislocated radial head (HP:0003083)1.50952849
182Renal cell carcinoma (HP:0005584)1.50718136
183Tetraparesis (HP:0002273)1.50395542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.75050717
2CDK123.49485044
3PDK23.46678933
4NTRK32.96793600
5MAP3K22.86765855
6AKT32.86098738
7MST1R2.68981482
8ICK2.59263373
9RIPK42.55277492
10EEF2K2.39075239
11HIPK22.29731076
12LATS12.15071053
13INSRR2.12344842
14FRK2.12271663
15CDK62.09518676
16MAP3K131.93364226
17PASK1.83769422
18KSR21.76141959
19SCYL21.74565696
20FGFR21.73082529
21EPHA41.63490468
22MAP3K91.61601610
23RET1.56647509
24FGFR31.56467699
25MAP3K11.55233739
26MAP3K121.54177238
27YES11.53023739
28SMG11.50734865
29JAK31.50525229
30BMPR21.48819367
31TGFBR21.47852584
32RIPK11.46617243
33SIK21.45633587
34TAOK31.39725584
35JAK11.39037386
36LATS21.37942450
37PTK61.37319317
38PRKCH1.31151539
39BRSK21.29677882
40SIK31.28904014
41EIF2AK31.28371517
42DAPK21.26445822
43WNK11.24485337
44MTOR1.23701089
45SIK11.20370540
46CAMKK11.18932411
47PRKD31.16564539
48STK391.14905580
49ITK1.13227475
50PBK1.11568307
51NUAK11.10524464
52RPS6KB21.10436995
53MAP3K141.09411605
54MET1.08487074
55MAP2K41.05683798
56NTRK11.05358042
57TRPM71.03372403
58JAK21.02806154
59TYRO31.01927216
60PIK3CG1.00169387
61MELK0.99400069
62MAP3K40.98856866
63TTN0.98078066
64MAP4K10.96382967
65TNIK0.93529950
66MAP3K100.93095475
67UHMK10.92089397
68LMTK20.92006056
69FES0.91095917
70CDK50.89530521
71DMPK0.89403221
72PRKCQ0.87436184
73MKNK10.86899327
74MAP2K70.86520491
75KSR10.83928548
76EPHA30.83321006
77GRK50.83042795
78PAK60.82610722
79CAMK1D0.82266598
80TYK20.80702820
81CDK30.80367855
82WNK30.80269597
83PDK10.79458446
84PAK30.78552000
85CAMKK20.77983476
86MINK10.77583790
87MAP2K30.77476734
88RAF10.76436974
89WNK40.76103145
90STK110.75926940
91PTK2B0.75196233
92PDGFRB0.75061081
93FGR0.73251146
94ERBB30.71909240
95ERBB40.70928819
96TRIB30.70771347
97PDGFRA0.70690576
98FGFR40.70680528
99RPS6KB10.69932284
100ERN10.68980712
101MAP3K30.68376285
102CDK40.67655029
103PNCK0.67616394
104CSF1R0.66681268
105CSNK1G20.66007576
106MAP2K20.65246831
107PTK20.63949852
108ALK0.62490960
109STK100.62369230
110TNK20.62192368
111CSK0.62022652
112HCK0.61529237
113SGK30.61409613
114SYK0.61158528
115PIM10.60442625
116MAP3K60.58391401
117MAPK110.58377653
118NTRK20.58303003
119NEK90.57261985
120NEK60.57035022
121FYN0.56959190
122CAMK1G0.56849850
123SGK10.55846628
124IKBKE0.55674005
125TEC0.55111935
126DYRK1B0.54142556
127PRKCE0.53715038
128TXK0.53110089
129CDC42BPA0.52759101
130MOS0.52575375
131STK380.52502410
132PKN20.51905377
133NLK0.51844138
134MAPK120.51251555
135MAPK100.50899876
136BRAF0.50660413
137IGF1R0.50063050
138CDK90.49501523
139PDPK10.48722636
140INSR0.47101799
141LCK0.46620526
142MAP3K70.45738490
143SGK20.45540584
144BRD40.45446396
145PRKD20.44880794
146CHEK10.44708311
147MAPK40.44601419
148PAK20.44287671
149PRKD10.43290430
150MAPK70.43286085
151STK30.43230638
152BRSK10.42184544
153STK240.40394732
154SGK4940.40250777
155SGK2230.40250777
156EIF2AK20.39295014
157PRKAA10.38720551
158EIF2AK10.37982999

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30174826
2Arginine biosynthesis_Homo sapiens_hsa002202.27578570
3Thyroid cancer_Homo sapiens_hsa052162.23226311
4Insulin secretion_Homo sapiens_hsa049112.02862240
5Circadian rhythm_Homo sapiens_hsa047102.00700516
6Maturity onset diabetes of the young_Homo sapiens_hsa049501.95091538
7Long-term potentiation_Homo sapiens_hsa047201.91564167
8Colorectal cancer_Homo sapiens_hsa052101.77433772
9Amphetamine addiction_Homo sapiens_hsa050311.64054608
10Type II diabetes mellitus_Homo sapiens_hsa049301.63187234
11Type I diabetes mellitus_Homo sapiens_hsa049401.60975067
12Complement and coagulation cascades_Homo sapiens_hsa046101.60840743
13Renin secretion_Homo sapiens_hsa049241.58476462
14FoxO signaling pathway_Homo sapiens_hsa040681.57516209
15Circadian entrainment_Homo sapiens_hsa047131.56348500
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54470635
17Adherens junction_Homo sapiens_hsa045201.52890530
18Cocaine addiction_Homo sapiens_hsa050301.51634853
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48104723
20Morphine addiction_Homo sapiens_hsa050321.46232357
21Olfactory transduction_Homo sapiens_hsa047401.45359195
22Cholinergic synapse_Homo sapiens_hsa047251.45051008
23Dopaminergic synapse_Homo sapiens_hsa047281.42780673
24GABAergic synapse_Homo sapiens_hsa047271.39536342
25Salivary secretion_Homo sapiens_hsa049701.37821366
26Glutamatergic synapse_Homo sapiens_hsa047241.36998192
27Gastric acid secretion_Homo sapiens_hsa049711.36876496
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35757325
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34007661
30Small cell lung cancer_Homo sapiens_hsa052221.32911415
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28736693
32Dorso-ventral axis formation_Homo sapiens_hsa043201.27467800
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27382508
34Estrogen signaling pathway_Homo sapiens_hsa049151.26796238
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.24297557
36Insulin signaling pathway_Homo sapiens_hsa049101.24030187
37Nitrogen metabolism_Homo sapiens_hsa009101.23969645
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23072354
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.20949892
40Synaptic vesicle cycle_Homo sapiens_hsa047211.20714041
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16949174
42GnRH signaling pathway_Homo sapiens_hsa049121.16470854
43Long-term depression_Homo sapiens_hsa047301.12761067
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11635501
45Oxytocin signaling pathway_Homo sapiens_hsa049211.10097261
46Pancreatic secretion_Homo sapiens_hsa049721.09128991
47Nicotine addiction_Homo sapiens_hsa050331.09025715
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07576196
49MicroRNAs in cancer_Homo sapiens_hsa052061.07286478
50Lysine degradation_Homo sapiens_hsa003101.07093622
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05996536
52T cell receptor signaling pathway_Homo sapiens_hsa046601.05520808
53B cell receptor signaling pathway_Homo sapiens_hsa046621.04945900
54cAMP signaling pathway_Homo sapiens_hsa040241.04806705
55Hepatitis B_Homo sapiens_hsa051611.04713174
56Phenylalanine metabolism_Homo sapiens_hsa003601.03573302
57Platelet activation_Homo sapiens_hsa046111.03138603
58Osteoclast differentiation_Homo sapiens_hsa043801.02823429
59Glioma_Homo sapiens_hsa052141.02671817
60Selenocompound metabolism_Homo sapiens_hsa004501.01659935
61VEGF signaling pathway_Homo sapiens_hsa043701.01574361
62Serotonergic synapse_Homo sapiens_hsa047261.01343514
63Gap junction_Homo sapiens_hsa045401.01180873
64Chemokine signaling pathway_Homo sapiens_hsa040621.00636139
65Thyroid hormone synthesis_Homo sapiens_hsa049181.00380684
66Viral carcinogenesis_Homo sapiens_hsa052031.00304338
67Biosynthesis of amino acids_Homo sapiens_hsa012300.99349981
68Prolactin signaling pathway_Homo sapiens_hsa049170.98754914
69Prion diseases_Homo sapiens_hsa050200.97534474
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96171528
71TGF-beta signaling pathway_Homo sapiens_hsa043500.95376047
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95347779
73Vibrio cholerae infection_Homo sapiens_hsa051100.95315456
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93234921
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.93111326
76Taste transduction_Homo sapiens_hsa047420.90788181
77Melanogenesis_Homo sapiens_hsa049160.90243244
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89340522
79ErbB signaling pathway_Homo sapiens_hsa040120.88888201
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.88865045
81Inositol phosphate metabolism_Homo sapiens_hsa005620.85812796
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84617054
83Renal cell carcinoma_Homo sapiens_hsa052110.84102318
84Leishmaniasis_Homo sapiens_hsa051400.83999803
85Bladder cancer_Homo sapiens_hsa052190.83272469
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.82109863
87TNF signaling pathway_Homo sapiens_hsa046680.81694183
88AMPK signaling pathway_Homo sapiens_hsa041520.81549409
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79833289
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78964833
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.78195317
92mRNA surveillance pathway_Homo sapiens_hsa030150.78108968
93Hepatitis C_Homo sapiens_hsa051600.77390714
94MAPK signaling pathway_Homo sapiens_hsa040100.77132771
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77063033
96Chronic myeloid leukemia_Homo sapiens_hsa052200.76853190
97Calcium signaling pathway_Homo sapiens_hsa040200.76019005
98Measles_Homo sapiens_hsa051620.75932215
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75909194
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75231740
101Non-small cell lung cancer_Homo sapiens_hsa052230.73792427
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73704055
103Toxoplasmosis_Homo sapiens_hsa051450.72783065
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72622078
105p53 signaling pathway_Homo sapiens_hsa041150.72290913
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71998331
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71666266
108Endometrial cancer_Homo sapiens_hsa052130.71476748
109Insulin resistance_Homo sapiens_hsa049310.70429121
110Rap1 signaling pathway_Homo sapiens_hsa040150.69791417
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.68597297
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.66785174
113Pancreatic cancer_Homo sapiens_hsa052120.65689832
114Endocytosis_Homo sapiens_hsa041440.65004888
115mTOR signaling pathway_Homo sapiens_hsa041500.64841790
116Ras signaling pathway_Homo sapiens_hsa040140.64831019
117Focal adhesion_Homo sapiens_hsa045100.64424594
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63669527
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.63507325
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63423092
121Proteoglycans in cancer_Homo sapiens_hsa052050.62182770
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.61304084
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61278136
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60327132
125Axon guidance_Homo sapiens_hsa043600.60212789
126Dilated cardiomyopathy_Homo sapiens_hsa054140.59799651
127Amoebiasis_Homo sapiens_hsa051460.59570990
128Other glycan degradation_Homo sapiens_hsa005110.59007734
129Choline metabolism in cancer_Homo sapiens_hsa052310.58942578
130Acute myeloid leukemia_Homo sapiens_hsa052210.58939910
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.58701174
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58086065
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57392577
134Tuberculosis_Homo sapiens_hsa051520.57350704
135Glucagon signaling pathway_Homo sapiens_hsa049220.57010946
136Prostate cancer_Homo sapiens_hsa052150.56770820
137Cell cycle_Homo sapiens_hsa041100.56621766
138Influenza A_Homo sapiens_hsa051640.56524039
139Lysosome_Homo sapiens_hsa041420.56032131
140Hippo signaling pathway_Homo sapiens_hsa043900.55939048
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55793763
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.55159629
143Bile secretion_Homo sapiens_hsa049760.54605357
144Vitamin B6 metabolism_Homo sapiens_hsa007500.53179151
145Pathways in cancer_Homo sapiens_hsa052000.52638459
146HTLV-I infection_Homo sapiens_hsa051660.52486324
147Caffeine metabolism_Homo sapiens_hsa002320.51955650
148Carbon metabolism_Homo sapiens_hsa012000.50392640
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.49598162
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47618967
151Starch and sucrose metabolism_Homo sapiens_hsa005000.46922341
152Herpes simplex infection_Homo sapiens_hsa051680.45675644
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44365042
154HIF-1 signaling pathway_Homo sapiens_hsa040660.43229007
155Apoptosis_Homo sapiens_hsa042100.42884258
156Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42242622

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