ZSWIM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1semaphorin-plexin signaling pathway (GO:0071526)5.42715743
2planar cell polarity pathway involved in neural tube closure (GO:0090179)4.83943668
3regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.36738003
4NIK/NF-kappaB signaling (GO:0038061)4.23023920
5response to muramyl dipeptide (GO:0032495)4.15561170
6mannose metabolic process (GO:0006013)4.06825797
7regulation of interleukin-12 biosynthetic process (GO:0045075)3.77684138
8cell-cell junction maintenance (GO:0045217)3.75200196
9positive regulation by symbiont of host defense response (GO:0052509)3.70330808
10modulation by symbiont of host defense response (GO:0052031)3.70330808
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70330808
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70330808
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.70330808
14modulation by symbiont of host immune response (GO:0052553)3.70330808
15atrioventricular valve morphogenesis (GO:0003181)3.48476948
16positive regulation of protein kinase C signaling (GO:0090037)3.40870162
17cellular response to ATP (GO:0071318)3.40742724
18regulation of apoptotic process involved in morphogenesis (GO:1902337)3.34530849
19regulation of NFAT protein import into nucleus (GO:0051532)3.28308924
20convergent extension (GO:0060026)3.22411754
21adenosine receptor signaling pathway (GO:0001973)3.15221610
22cellular extravasation (GO:0045123)3.11122070
23leukocyte aggregation (GO:0070486)3.10260215
24basement membrane organization (GO:0071711)3.08948636
25modulation by symbiont of host cellular process (GO:0044068)3.07658455
26endocytic recycling (GO:0032456)3.00789380
27regulation of gamma-delta T cell activation (GO:0046643)2.99510059
28positive regulation of p38MAPK cascade (GO:1900745)2.99148965
29negative regulation of interleukin-8 production (GO:0032717)2.98856596
30Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.97878246
31positive regulation of gamma-delta T cell activation (GO:0046645)2.95598227
32wound healing, spreading of epidermal cells (GO:0035313)2.93278604
33dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89223650
34positive regulation of chemokine biosynthetic process (GO:0045080)2.88819544
35regulation of synapse structural plasticity (GO:0051823)2.88812211
36regulation of heat generation (GO:0031650)2.84855763
37regulation of gamma-delta T cell differentiation (GO:0045586)2.83777727
38activation of MAPKKK activity (GO:0000185)2.83253344
39positive thymic T cell selection (GO:0045059)2.82450200
40myeloid dendritic cell differentiation (GO:0043011)2.81287564
41negative regulation of cell aging (GO:0090344)2.80157513
42regulation of establishment of planar polarity (GO:0090175)2.77234163
43epithelial cell-cell adhesion (GO:0090136)2.76599244
44stress fiber assembly (GO:0043149)2.75946317
45cell junction maintenance (GO:0034331)2.75205669
46positive regulation of odontogenesis (GO:0042482)2.74604922
47regulation of podosome assembly (GO:0071801)2.67504059
48lens fiber cell differentiation (GO:0070306)2.66722741
49positive regulation of heat generation (GO:0031652)2.66034032
50peptidyl-glutamic acid carboxylation (GO:0017187)2.65575156
51protein carboxylation (GO:0018214)2.65575156
52decidualization (GO:0046697)2.64579133
53macrophage activation involved in immune response (GO:0002281)2.64012238
54response to laminar fluid shear stress (GO:0034616)2.63797402
55negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.63700155
56T cell apoptotic process (GO:0070231)2.63674663
57morphogenesis of an endothelium (GO:0003159)2.62666732
58endothelial tube morphogenesis (GO:0061154)2.62666732
59regulation of early endosome to late endosome transport (GO:2000641)2.62039487
60regulation of integrin activation (GO:0033623)2.61455289
61cellular response to vitamin D (GO:0071305)2.61361768
62mitotic cell cycle arrest (GO:0071850)2.60444539
63adherens junction assembly (GO:0034333)2.59101653
64cell migration in hindbrain (GO:0021535)2.58652941
65negative regulation of erythrocyte differentiation (GO:0045647)2.57767002
66endothelial cell chemotaxis (GO:0035767)2.57296525
673-UTR-mediated mRNA stabilization (GO:0070935)2.56759147
68skin morphogenesis (GO:0043589)2.54307238
69osteoblast development (GO:0002076)2.53696192
70neutrophil activation involved in immune response (GO:0002283)2.53672599
71actin filament bundle assembly (GO:0051017)2.52607702
72actin filament bundle organization (GO:0061572)2.52607702
73regulation of p38MAPK cascade (GO:1900744)2.52270860
74negative regulation of interleukin-12 production (GO:0032695)2.50934307
75negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.50061512
76vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49854290
77ear development (GO:0043583)2.49680522
78GDP-mannose metabolic process (GO:0019673)2.49377664
79positive regulation of histone deacetylation (GO:0031065)2.48936895
80myeloid dendritic cell activation (GO:0001773)2.47916060
81regulation of ARF GTPase activity (GO:0032312)2.45720350
82granulocyte activation (GO:0036230)2.44459019
83regulation of skeletal muscle contraction (GO:0014819)2.43811840
84regulation of cytokine production involved in inflammatory response (GO:1900015)2.43630795
85response to peptidoglycan (GO:0032494)2.42794874
86leukocyte cell-cell adhesion (GO:0007159)2.42696365
87negative regulation of cytokine production involved in immune response (GO:0002719)2.42694940
88mRNA stabilization (GO:0048255)2.40482353
89RNA stabilization (GO:0043489)2.40482353
90establishment of apical/basal cell polarity (GO:0035089)2.39660042
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.39384354
92germ cell migration (GO:0008354)2.39231713
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39036760
94pre-miRNA processing (GO:0031054)2.37313318
95response to vitamin D (GO:0033280)2.37221681
96phosphatidylglycerol biosynthetic process (GO:0006655)2.36985145
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36341031
98tolerance induction (GO:0002507)2.35441779
99protein heterotrimerization (GO:0070208)2.35246091
100cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.35120123
101focal adhesion assembly (GO:0048041)2.34664867
102cell-substrate adherens junction assembly (GO:0007045)2.34664867
103regulation of chronic inflammatory response (GO:0002676)2.34133334
104regulation of fever generation (GO:0031620)2.33905075
105cytokine secretion (GO:0050663)2.33004483
106negative regulation of cell killing (GO:0031342)2.32902303
107negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32902303
108positive regulation of fat cell differentiation (GO:0045600)2.32818964
109non-canonical Wnt signaling pathway (GO:0035567)2.32477308
110glial cell migration (GO:0008347)2.31742594
111Rho protein signal transduction (GO:0007266)2.31660642
112branching involved in salivary gland morphogenesis (GO:0060445)2.31576638
113endodermal cell differentiation (GO:0035987)2.31545029
114histone H3-K36 demethylation (GO:0070544)2.31043607
115regulation of vitamin D biosynthetic process (GO:0060556)2.30706004
116wound healing, spreading of cells (GO:0044319)2.30642745
117cell adhesion mediated by integrin (GO:0033627)2.30543481
118mRNA transcription (GO:0009299)2.29631274
119establishment or maintenance of monopolar cell polarity (GO:0061339)2.29577676
120establishment of monopolar cell polarity (GO:0061162)2.29577676
121JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.29482363
122positive regulation of axonogenesis (GO:0050772)2.28207479
123regulation of chemokine biosynthetic process (GO:0045073)2.28036906
124positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.27969364
125tooth mineralization (GO:0034505)2.27372785
126protein retention in ER lumen (GO:0006621)2.26224180
127UV protection (GO:0009650)2.25196959
128trophoblast giant cell differentiation (GO:0060707)2.25046875
129negative regulation of toll-like receptor signaling pathway (GO:0034122)2.24944521
130neutrophil activation (GO:0042119)2.24695395
131regulation of interferon-beta biosynthetic process (GO:0045357)2.24311359
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.24002379
133regulation of membrane protein ectodomain proteolysis (GO:0051043)2.23985076
134positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.23649611
135thymic T cell selection (GO:0045061)2.23549529
136substrate-dependent cell migration (GO:0006929)2.23458715
137positive regulation of SMAD protein import into nucleus (GO:0060391)2.22732256
138cochlea morphogenesis (GO:0090103)2.22729374
139mRNA transcription from RNA polymerase II promoter (GO:0042789)2.22132223
140cytoplasmic mRNA processing body assembly (GO:0033962)2.20929051
141negative regulation of tumor necrosis factor production (GO:0032720)2.20663916
142neural tube development (GO:0021915)2.20415944
143cell-substrate junction assembly (GO:0007044)2.19890639
144response to progesterone (GO:0032570)2.19483487
145venous blood vessel morphogenesis (GO:0048845)2.18977426
146dosage compensation (GO:0007549)2.18742623
147regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.18146294
148positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.18146294
149positive regulation of interleukin-12 production (GO:0032735)2.17597075
150protein localization to endosome (GO:0036010)2.17467120
151response to host (GO:0075136)2.17146179
152response to host defenses (GO:0052200)2.17146179
153response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.17146179
154positive T cell selection (GO:0043368)2.17137702
155regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.16611650
156regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.15556304
157apoptotic process involved in morphogenesis (GO:0060561)2.15305343
158nuclear pore complex assembly (GO:0051292)2.14987824
159regulation of interleukin-12 production (GO:0032655)2.14319395
160regulation of SMAD protein import into nucleus (GO:0060390)2.14033784
161positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.13956746
162regulation of type I interferon-mediated signaling pathway (GO:0060338)2.13711075
163positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.12872885
164regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.12745805
165regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.12298780
166positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.11846611
167nodal signaling pathway (GO:0038092)2.11766917
168immunoglobulin mediated immune response (GO:0016064)2.10919803
169lymphocyte apoptotic process (GO:0070227)2.10689597
170monocyte chemotaxis (GO:0002548)2.10644730
171response to UV-C (GO:0010225)2.10053936
172positive regulation of leukocyte apoptotic process (GO:2000108)2.09638664
173cellular response to virus (GO:0098586)2.09144568
174positive regulation of humoral immune response (GO:0002922)2.09130208
175tyrosine phosphorylation of STAT protein (GO:0007260)2.09042641
176positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.08222798
177regulation of interferon-alpha production (GO:0032647)2.07980701
178cellular response to nicotine (GO:0071316)2.07973936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.41244368
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.42644762
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.00623193
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33338114
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.30293035
6E2F7_22180533_ChIP-Seq_HELA_Human3.20940274
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.00549356
8MYC_22102868_ChIP-Seq_BL_Human2.92880185
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.91480209
10TCF7_22412390_ChIP-Seq_EML_Mouse2.54389267
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52398134
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.49309625
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.49179943
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.44074611
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.39923514
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36616560
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29814956
18VDR_21846776_ChIP-Seq_THP-1_Human2.29507906
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.26543544
20KDM2B_26808549_Chip-Seq_DND41_Human2.24233690
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.11392520
22* ELK3_25401928_ChIP-Seq_HUVEC_Human2.08078749
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06082266
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05845275
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03250319
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02271504
27P68_20966046_ChIP-Seq_HELA_Human2.02126994
28MAF_26560356_Chip-Seq_TH1_Human2.01813305
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94880392
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.91149938
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.85687073
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84624187
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81895699
34* UTX_26944678_Chip-Seq_JUKART_Human1.81570841
35VDR_24763502_ChIP-Seq_THP-1_Human1.81192041
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79025875
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78100542
38* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76157177
39* TP53_22127205_ChIP-Seq_IMR90_Human1.74539286
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.74420070
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72317849
42CTCF_27219007_Chip-Seq_Bcells_Human1.72207234
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71843160
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69743131
45KDM2B_26808549_Chip-Seq_JURKAT_Human1.65910557
46CREB1_26743006_Chip-Seq_LNCaP_Human1.65205523
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63832967
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63078619
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.59074624
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58259287
51* SA1_27219007_Chip-Seq_ERYTHROID_Human1.54756550
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.54047160
53MYB_26560356_Chip-Seq_TH2_Human1.53904471
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52125364
55CLOCK_20551151_ChIP-Seq_293T_Human1.51576957
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51336634
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50445630
58* SMC4_20622854_ChIP-Seq_HELA_Human1.49403016
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.48819335
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45856447
61RUNX_20019798_ChIP-Seq_JUKART_Human1.45263187
62* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43526336
63SCL_19346495_ChIP-Seq_HPC-7_Human1.42891889
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42076068
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40590247
66KDM2B_26808549_Chip-Seq_K562_Human1.40545327
67MYB_26560356_Chip-Seq_TH1_Human1.40362891
68BCOR_27268052_Chip-Seq_Bcells_Human1.39650818
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39010806
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.38908581
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38229725
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37647513
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36371469
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36138061
75* ATF3_27146783_Chip-Seq_COLON_Human1.34825193
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34727530
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34727530
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.33625549
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32783744
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32618538
81BCL6_27268052_Chip-Seq_Bcells_Human1.32555160
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32516024
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29623411
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29616492
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.29020292
86RACK7_27058665_Chip-Seq_MCF-7_Human1.27503693
87E2F1_20622854_ChIP-Seq_HELA_Human1.26940253
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26306106
89* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26222376
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25947962
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23653745
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23214735
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21703491
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.21007270
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20823018
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20823018
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20823018
98SPI1_23127762_ChIP-Seq_K562_Human1.19983138
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18864992
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18408128
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17875781
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.17816058
103* RARB_24833708_ChIP-Seq_LIVER_Mouse1.17621716
104NCOR1_26117541_ChIP-Seq_K562_Human1.17364606
105MAF_26560356_Chip-Seq_TH2_Human1.16316853
106PHF8_20622854_ChIP-Seq_HELA_Human1.16057092
107RARA_24833708_ChIP-Seq_LIVER_Mouse1.15851084
108ESR1_21235772_ChIP-Seq_MCF-7_Human1.15556291
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15047247
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14651265
111* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14641931
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14301657
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12067649
114SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10460979
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10397736
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10080890
117VDR_24787735_ChIP-Seq_THP-1_Human1.09913736
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.09807135
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08575391
120SPI1_23547873_ChIP-Seq_NB4_Human1.08202537
121OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08164503
122SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06906378
123* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06725850
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05841744
125SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05051707
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.03891602
127P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03695400
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03655889
129TP63_22573176_ChIP-Seq_HFKS_Human1.03056622
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02890548
131LXR_22292898_ChIP-Seq_THP-1_Human1.02026965
132TP53_20018659_ChIP-ChIP_R1E_Mouse1.01945057
133CTCF_21964334_Chip-Seq_Bcells_Human1.01480263
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01460048
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00499927
136SA1_27219007_Chip-Seq_Bcells_Human1.00406743
137* TP53_23651856_ChIP-Seq_MEFs_Mouse1.00280879
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98974792
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98788583
140PU_27001747_Chip-Seq_BMDM_Mouse0.98524025
141* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97881843
142JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97572686
143ESR2_21235772_ChIP-Seq_MCF-7_Human0.97317125
144* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97282225
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96160532
146EZH2_27294783_Chip-Seq_ESCs_Mouse0.96105403
147* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95989865
148JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94399947
149RUNX1_27514584_Chip-Seq_MCF-7_Human0.93563994
150ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93465556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.43622472
2MP0009278_abnormal_bone_marrow3.31146024
3MP0005409_darkened_coat_color3.24635440
4MP0003436_decreased_susceptibility_to2.95735920
5MP0005076_abnormal_cell_differentiation2.92474033
6MP0009840_abnormal_foam_cell2.85112001
7MP0004510_myositis2.69443504
8MP0005171_absent_coat_pigmentation2.65532781
9MP0003705_abnormal_hypodermis_morpholog2.55830596
10MP0010352_gastrointestinal_tract_polyps2.42185961
11MP0005423_abnormal_somatic_nervous2.24138084
12MP0003300_gastrointestinal_ulcer2.21910099
13MP0004947_skin_inflammation2.18909027
14MP0000685_abnormal_immune_system2.06297481
15MP0001835_abnormal_antigen_presentation1.94820495
16MP0005058_abnormal_lysosome_morphology1.94362944
17MP0005000_abnormal_immune_tolerance1.89097393
18MP0000750_abnormal_muscle_regeneration1.87043240
19MP0003566_abnormal_cell_adhesion1.83174806
20MP0004858_abnormal_nervous_system1.82747559
21MP0003448_altered_tumor_morphology1.82526705
22MP0009785_altered_susceptibility_to1.77446931
23MP0005083_abnormal_biliary_tract1.76393632
24MP0002452_abnormal_antigen_presenting1.75721380
25MP0000733_abnormal_muscle_development1.75420301
26MP0002796_impaired_skin_barrier1.74961889
27MP0002254_reproductive_system_inflammat1.72732933
28MP0001800_abnormal_humoral_immune1.71039043
29MP0002405_respiratory_system_inflammati1.68265947
30MP0002419_abnormal_innate_immunity1.65768635
31MP0001545_abnormal_hematopoietic_system1.65552113
32MP0005397_hematopoietic_system_phenotyp1.65552113
33MP0000751_myopathy1.65350249
34MP0006082_CNS_inflammation1.63547141
35MP0004272_abnormal_basement_membrane1.62599003
36MP0001790_abnormal_immune_system1.62341238
37MP0005387_immune_system_phenotype1.62341238
38MP0005501_abnormal_skin_physiology1.60767755
39MP0002089_abnormal_postnatal_growth/wei1.58965785
40MP0010307_abnormal_tumor_latency1.56703962
41MP0009333_abnormal_splenocyte_physiolog1.55754549
42MP0003172_abnormal_lysosome_physiology1.55517442
43MP0003453_abnormal_keratinocyte_physiol1.53520357
44MP0000569_abnormal_digit_pigmentation1.53351937
45MP0003091_abnormal_cell_migration1.53071381
46MP0002723_abnormal_immune_serum1.52409035
47MP0000678_abnormal_parathyroid_gland1.51223957
48MP0002148_abnormal_hypersensitivity_rea1.50517502
49MP0005025_abnormal_response_to1.48200671
50MP0003763_abnormal_thymus_physiology1.45222104
51MP0001819_abnormal_immune_cell1.44827138
52MP0001533_abnormal_skeleton_physiology1.43889640
53MP0001188_hyperpigmentation1.43514271
54MP0005023_abnormal_wound_healing1.43367371
55MP0002420_abnormal_adaptive_immunity1.43105762
56MP0004808_abnormal_hematopoietic_stem1.41937844
57MP0005174_abnormal_tail_pigmentation1.40431712
58MP0000858_altered_metastatic_potential1.40011620
59MP0003724_increased_susceptibility_to1.34068499
60MP0002933_joint_inflammation1.30666175
61MP0009384_cardiac_valve_regurgitation1.29317972
62MP0010155_abnormal_intestine_physiology1.27228219
63MP0009053_abnormal_anal_canal1.26166681
64MP0002398_abnormal_bone_marrow1.24360045
65MP0005671_abnormal_response_to1.22694250
66MP0002138_abnormal_hepatobiliary_system1.21399578
67MP0002006_tumorigenesis1.21397785
68MP0010368_abnormal_lymphatic_system1.18743558
69MP0001542_abnormal_bone_strength1.18704368
70MP0000767_abnormal_smooth_muscle1.18360550
71MP0000003_abnormal_adipose_tissue1.17881664
72MP0002277_abnormal_respiratory_mucosa1.15685143
73MP0001879_abnormal_lymphatic_vessel1.15511939
74MP0003136_yellow_coat_color1.15157116
75MP0000703_abnormal_thymus_morphology1.14313217
76MP0005377_hearing/vestibular/ear_phenot1.12254618
77MP0003878_abnormal_ear_physiology1.12254618
78MP0005390_skeleton_phenotype1.12103656
79MP0001853_heart_inflammation1.11331441
80MP0001502_abnormal_circadian_rhythm1.10407035
81MP0000716_abnormal_immune_system1.08631096
82MP0002166_altered_tumor_susceptibility1.08366629
83MP0004381_abnormal_hair_follicle1.07122722
84MP0005275_abnormal_skin_tensile1.05331868
85MP0001851_eye_inflammation1.04672120
86MP0004197_abnormal_fetal_growth/weight/1.02990521
87MP0000490_abnormal_crypts_of1.02946194
88MP0003828_pulmonary_edema1.01781733
89MP0001845_abnormal_inflammatory_respons1.00627116
90MP0002998_abnormal_bone_remodeling0.99928520
91MP0000689_abnormal_spleen_morphology0.99325251
92MP0001958_emphysema0.98944663
93MP0002722_abnormal_immune_system0.98614353
94MP0005375_adipose_tissue_phenotype0.98185003
95MP0000350_abnormal_cell_proliferation0.98121246
96MP0009931_abnormal_skin_appearance0.96312119
97MP0001986_abnormal_taste_sensitivity0.96131697
98MP0005623_abnormal_meninges_morphology0.96115019
99MP0001243_abnormal_dermal_layer0.95723289
100MP0001873_stomach_inflammation0.95626154
101MP0003941_abnormal_skin_development0.94455120
102MP0001216_abnormal_epidermal_layer0.94385273
103MP0008007_abnormal_cellular_replicative0.94262232
104MP0002925_abnormal_cardiovascular_devel0.94082278
105MP0005464_abnormal_platelet_physiology0.92569090
106MP0010030_abnormal_orbit_morphology0.92384268
107MP0002060_abnormal_skin_morphology0.91807912
108MP0005595_abnormal_vascular_smooth0.90421426
109MP0002429_abnormal_blood_cell0.90222415
110MP0005330_cardiomyopathy0.88356308
111MP0001614_abnormal_blood_vessel0.88205371
112MP0000343_altered_response_to0.87924244
113MP0008438_abnormal_cutaneous_collagen0.87089502
114MP0000465_gastrointestinal_hemorrhage0.86375369
115MP0002877_abnormal_melanocyte_morpholog0.86130159
116MP0003279_aneurysm0.85138977
117MP0001915_intracranial_hemorrhage0.84535033
118MP0001849_ear_inflammation0.84158694
119MP0002282_abnormal_trachea_morphology0.82959766
120MP0004133_heterotaxia0.80065855
121MP0004185_abnormal_adipocyte_glucose0.79543977
122MP0008961_abnormal_basal_metabolism0.79318831
123MP0002088_abnormal_embryonic_growth/wei0.77999725
124MP0010771_integument_phenotype0.77822658
125MP0001348_abnormal_lacrimal_gland0.77565320
126MP0002086_abnormal_extraembryonic_tissu0.77267503
127MP0005257_abnormal_intraocular_pressure0.76524316
128MP0000249_abnormal_blood_vessel0.76322532
129MP0003984_embryonic_growth_retardation0.75811509
130MP0002697_abnormal_eye_size0.75664287
131MP0003077_abnormal_cell_cycle0.74903106
132MP0005167_abnormal_blood-brain_barrier0.74003459
133MP0000537_abnormal_urethra_morphology0.73697119
134MP0001191_abnormal_skin_condition0.73533288
135MP0000377_abnormal_hair_follicle0.73266371
136MP0002896_abnormal_bone_mineralization0.72936411
137MP0005508_abnormal_skeleton_morphology0.72369690
138MP0005197_abnormal_uvea_morphology0.72336667
139MP0000470_abnormal_stomach_morphology0.71587763
140MP0000538_abnormal_urinary_bladder0.68268403
141MP0003942_abnormal_urinary_system0.67943947
142MP0005503_abnormal_tendon_morphology0.67770332
143MP0002113_abnormal_skeleton_development0.67550178
144MP0002249_abnormal_larynx_morphology0.65936351
145MP0003329_amyloid_beta_deposits0.62724041
146MP0000013_abnormal_adipose_tissue0.62189687
147MP0001784_abnormal_fluid_regulation0.62144264
148MP0000778_abnormal_nervous_system0.61450084
149MP0009764_decreased_sensitivity_to0.60044026

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)4.96915101
2Stomatitis (HP:0010280)4.62458906
3Eczematoid dermatitis (HP:0000976)4.16808654
4Rib fusion (HP:0000902)3.80114726
5Turricephaly (HP:0000262)3.59519583
6Mesangial abnormality (HP:0001966)3.56428206
7Recurrent abscess formation (HP:0002722)3.30754906
8Increased density of long bones (HP:0006392)3.30374666
9Elevated erythrocyte sedimentation rate (HP:0003565)3.21034161
10Hemorrhage of the eye (HP:0011885)3.19343846
11Obstructive sleep apnea (HP:0002870)3.17460775
12Cervical subluxation (HP:0003308)3.11229963
13Mediastinal lymphadenopathy (HP:0100721)3.06782718
14Annular pancreas (HP:0001734)3.03721263
15Persistence of primary teeth (HP:0006335)2.96574621
16Recurrent bacterial skin infections (HP:0005406)2.94897998
17Delayed epiphyseal ossification (HP:0002663)2.90690930
18Joint stiffness (HP:0001387)2.88082265
19Testicular atrophy (HP:0000029)2.77096059
20Aplasia of the musculature (HP:0100854)2.71467562
21Orchitis (HP:0100796)2.70804798
22Coronal craniosynostosis (HP:0004440)2.69056414
23Thick nail (HP:0001805)2.67974518
24Myositis (HP:0100614)2.60551083
25Retrobulbar optic neuritis (HP:0100654)2.60413086
26Optic neuritis (HP:0100653)2.60413086
27Thin ribs (HP:0000883)2.59901147
28Choroideremia (HP:0001139)2.57824188
29Cerebral aneurysm (HP:0004944)2.54064029
30Poikiloderma (HP:0001029)2.53281196
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52799513
32Short 4th metacarpal (HP:0010044)2.52799513
33Broad metatarsal (HP:0001783)2.45134372
34Intestinal fistula (HP:0100819)2.45000546
35Abnormality of the nasal septum (HP:0000419)2.41447819
36Hematochezia (HP:0002573)2.40439711
37Bowed forearm bones (HP:0003956)2.39695154
38Bowing of the arm (HP:0006488)2.39695154
39Abnormality of the fingertips (HP:0001211)2.33622260
40Squamous cell carcinoma (HP:0002860)2.32901299
41Vaginal fistula (HP:0004320)2.30933320
42Recurrent fungal infections (HP:0002841)2.29963969
43Enlarged epiphyses (HP:0010580)2.29843251
44Rectovaginal fistula (HP:0000143)2.26457762
45Rectal fistula (HP:0100590)2.26457762
46Shallow orbits (HP:0000586)2.24985827
47Facial hemangioma (HP:0000329)2.23779438
48Dyschromatopsia (HP:0007641)2.23323406
49Choanal stenosis (HP:0000452)2.19634957
50Distal lower limb amyotrophy (HP:0008944)2.18475954
51Long palpebral fissure (HP:0000637)2.16450387
52Gingivitis (HP:0000230)2.14939948
53Broad face (HP:0000283)2.14196509
54Myocardial infarction (HP:0001658)2.12483371
55Recurrent gram-negative bacterial infections (HP:0005420)2.10399241
56Arterial thrombosis (HP:0004420)2.10280425
57Spina bifida occulta (HP:0003298)2.08344444
58Fetal akinesia sequence (HP:0001989)2.06755218
59Cellulitis (HP:0100658)2.06146946
60Tibial bowing (HP:0002982)2.06036819
61Aortic aneurysm (HP:0004942)2.05456252
62Leukocytosis (HP:0001974)2.04911816
63Femoral bowing (HP:0002980)2.04905863
64Urethral obstruction (HP:0000796)2.04715201
65Autoimmune thrombocytopenia (HP:0001973)2.04471051
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03881186
67Popliteal pterygium (HP:0009756)2.02670742
68Syringomyelia (HP:0003396)2.02420304
69Spinal cord lesions (HP:0100561)2.02420304
70Protrusio acetabuli (HP:0003179)1.99872724
71Dilatation of the ascending aorta (HP:0005111)1.99201194
72Peritonitis (HP:0002586)1.98142663
73Mitral valve prolapse (HP:0001634)1.97771500
74Atrophic scars (HP:0001075)1.95880638
75Abnormality of the costochondral junction (HP:0000919)1.94577973
76Obstructive lung disease (HP:0006536)1.90734837
77Chronic obstructive pulmonary disease (HP:0006510)1.90734837
78Abnormality of macrophages (HP:0004311)1.88926168
79Abnormality of the peritoneum (HP:0002585)1.88659307
80Pulmonary infiltrates (HP:0002113)1.88569526
81Genu recurvatum (HP:0002816)1.87787406
82Narrow nasal bridge (HP:0000446)1.87590020
83Vasculitis (HP:0002633)1.86673586
84Rectal prolapse (HP:0002035)1.86530719
85Akinesia (HP:0002304)1.85143414
86Neurofibrillary tangles (HP:0002185)1.84088351
87Arterial tortuosity (HP:0005116)1.84032855
88Absent frontal sinuses (HP:0002688)1.83768954
89Abnormality of polysaccharide metabolism (HP:0011012)1.82940461
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82940461
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82940461
92Abnormality of the odontoid process (HP:0003310)1.81261543
93Overgrowth (HP:0001548)1.81173412
94Prostate neoplasm (HP:0100787)1.80427424
95Metaphyseal irregularity (HP:0003025)1.79296829
96Spontaneous hematomas (HP:0007420)1.76546679
97Premature skin wrinkling (HP:0100678)1.76027074
98Ankle contracture (HP:0006466)1.75756009
99Bronchomalacia (HP:0002780)1.75280102
100Pointed chin (HP:0000307)1.75192121
101Distal lower limb muscle weakness (HP:0009053)1.75135762
102Subacute progressive viral hepatitis (HP:0006572)1.74558791
103Biconcave vertebral bodies (HP:0004586)1.74057952
104Vertebral compression fractures (HP:0002953)1.73987214
105Achilles tendon contracture (HP:0001771)1.73896154
106Anteriorly placed anus (HP:0001545)1.73296839
107Abnormality of the 4th metacarpal (HP:0010012)1.72538359
108Increased connective tissue (HP:0009025)1.72065412
109Zonular cataract (HP:0010920)1.71676803
110Capillary hemangiomas (HP:0005306)1.71576288
111Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71412236
112Mucopolysacchariduria (HP:0008155)1.71179340
113Urinary glycosaminoglycan excretion (HP:0003541)1.71179340
114Bicuspid aortic valve (HP:0001647)1.70378374
115Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70105433
116Morphological abnormality of the middle ear (HP:0008609)1.69205939
117Abnormality of the thoracic spine (HP:0100711)1.68807134
118Thoracic kyphosis (HP:0002942)1.68688314
119Abnormality of the intrinsic pathway (HP:0010989)1.68608179
120Uterine leiomyosarcoma (HP:0002891)1.67930800
121Leiomyosarcoma (HP:0100243)1.67930800
122Short femoral neck (HP:0100864)1.67810003
123Emphysema (HP:0002097)1.67736637
124Recurrent viral infections (HP:0004429)1.67668559
125Hand muscle atrophy (HP:0009130)1.67620247
126Stridor (HP:0010307)1.67441463
127Lower limb amyotrophy (HP:0007210)1.67304050
128Porencephaly (HP:0002132)1.67172488
129Natal tooth (HP:0000695)1.66973444
130Vascular tortuosity (HP:0004948)1.65962446
131Wrist flexion contracture (HP:0001239)1.65599383
132Bilateral sensorineural hearing impairment (HP:0008619)1.64817164
133Broad thumb (HP:0011304)1.64334939
134Ectopia lentis (HP:0001083)1.63963097
135Long eyelashes (HP:0000527)1.63795747
136Pterygium (HP:0001059)1.63757529
137Trigonocephaly (HP:0000243)1.63569518
138Aortic dissection (HP:0002647)1.63135895
139Recurrent skin infections (HP:0001581)1.63130691
140Hypoplasia of the odontoid process (HP:0003311)1.62894687
141Flattened epiphyses (HP:0003071)1.62614867
142Bladder carcinoma (HP:0002862)1.62481186
143Bladder neoplasm (HP:0009725)1.62481186
144Distal upper limb amyotrophy (HP:0007149)1.61931220
145Upper limb amyotrophy (HP:0009129)1.61931220
146Lymphangioma (HP:0100764)1.61728030
147Patellar aplasia (HP:0006443)1.61136237
148Gastrointestinal infarctions (HP:0005244)1.60992961
149Skull defect (HP:0001362)1.60823881
150Somatic mutation (HP:0001428)1.60740356
151Difficulty climbing stairs (HP:0003551)1.60344735
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.60200852
153Osteolytic defects of the hand bones (HP:0009699)1.60200852
154Limited elbow extension (HP:0001377)1.60050892
155Fragile skin (HP:0001030)1.59148995
156Pustule (HP:0200039)1.59073620
157Increased IgE level (HP:0003212)1.58942220
158Hyperacusis (HP:0010780)1.58820179
159Elfin facies (HP:0004428)1.58534365
160Milia (HP:0001056)1.58402911
161Malignant gastrointestinal tract tumors (HP:0006749)1.58282826
162Gastrointestinal carcinoma (HP:0002672)1.58282826
163Joint hemorrhage (HP:0005261)1.58064481
164Vitreoretinal degeneration (HP:0000655)1.57467963
165Short chin (HP:0000331)1.57391309
166Abnormal trabecular bone morphology (HP:0100671)1.57200587
167Increased IgM level (HP:0003496)1.56942460
168Transitional cell carcinoma of the bladder (HP:0006740)1.56522546
169Heterotopia (HP:0002282)1.55816990
170Bladder diverticulum (HP:0000015)1.54932629
171Disproportionate tall stature (HP:0001519)1.54674276
172Dislocated radial head (HP:0003083)1.54198599
173Congenital hip dislocation (HP:0001374)1.54175695
174Cerebral inclusion bodies (HP:0100314)1.53801124
175Supernumerary ribs (HP:0005815)1.53678893
176Blue sclerae (HP:0000592)1.53496605
177Premature rupture of membranes (HP:0001788)1.53112397
178Ulnar bowing (HP:0003031)1.52907912
179Progressive hearing impairment (HP:0001730)1.51654003
180Aneurysm (HP:0002617)1.51594435
181Large earlobe (HP:0009748)1.50291986
182Fused cervical vertebrae (HP:0002949)1.49992632
183Camptodactyly of toe (HP:0001836)1.47634691
184Abnormality of the radial head (HP:0003995)1.45412327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.29273726
2MAP3K103.88250638
3MAP3K143.40370916
4SIK13.21665623
5CDK122.95688718
6TBK12.80412191
7EEF2K2.61325075
8TRIB32.42293347
9DDR22.34589372
10SMG12.30282841
11CHUK2.23886050
12MAP4K12.23121031
13RPS6KA42.20052526
14IKBKB2.05112134
15PKN21.92441861
16RIPK11.91163969
17PTK61.91056282
18MARK21.81244275
19EPHB21.79845491
20IKBKE1.78469569
21RPS6KA21.76702847
22BMX1.71660295
23CDC42BPA1.65892027
24STK101.58718225
25EPHB11.58053194
26TTN1.56039032
27MAP3K31.49606285
28JAK31.46737087
29TYK21.45548458
30TXK1.43266989
31TYRO31.42174640
32LATS21.41560123
33TGFBR21.40990007
34MATK1.36775700
35EPHA21.33737886
36PIM11.32809462
37HCK1.29793386
38MAP2K31.29226743
39TAOK11.29188705
40LATS11.24623320
41PRPF4B1.24450468
42NTRK11.23782624
43RPS6KL11.22094573
44RPS6KC11.22094573
45CSK1.21188668
46MAP3K61.20044903
47ERN11.18188304
48ZAP701.14646315
49CDK91.14000128
50FGFR41.12981179
51TGFBR11.09685924
52RPS6KA61.06457059
53ITK1.05876558
54BRD41.05642362
55MUSK1.05561165
56IRAK31.05251825
57ALK1.04994662
58BTK1.04062867
59SIK31.00505243
60BLK0.98738110
61CDK60.97912932
62MTOR0.96993135
63DMPK0.95221671
64TAOK20.94979436
65MAP3K110.93423905
66IRAK20.92792878
67PDGFRB0.92704443
68HIPK20.92557775
69IRAK40.91541729
70MAP3K130.90846271
71STK160.90461063
72FGFR30.86573019
73ICK0.86119045
74MST1R0.85300475
75MAP3K70.84105998
76SIK20.83733236
77STK30.83482398
78PTK20.83088028
79PDGFRA0.82732861
80CLK10.81352504
81PIM20.77799557
82MAP3K90.77668831
83CAMK1D0.76718031
84MKNK20.75047951
85ARAF0.74910020
86MAPK70.74159912
87FGFR10.72417966
88LRRK20.72327452
89RPS6KA10.72255681
90MELK0.71512893
91DYRK1B0.70795620
92MAP2K20.68529640
93RPS6KB20.65548299
94LCK0.65428716
95ERBB30.64268266
96PAK40.63930994
97PAK20.63606005
98NME20.62829044
99RIPK40.62704946
100EPHA30.62167494
101CDK40.62056995
102CAMK1G0.61530790
103RPS6KA50.61424308
104JAK10.61306790
105PDPK10.61031588
106EGFR0.60524593
107FGR0.59405068
108FES0.57627386
109NEK20.57448468
110MAP3K80.57005188
111WNK40.56375741
112TESK10.55225962
113INSR0.53692540
114JAK20.52922047
115BRAF0.51805506
116MAP3K10.51114951
117DYRK30.50929522
118MAPK40.49909902
119TIE10.48859756
120MAPKAPK20.47955299
121ABL10.46006043
122PRKD20.45935401
123ABL20.45611020
124STK40.44963754
125TEC0.44724746
126PRKD30.43727490
127MAPK80.43036244
128MET0.42522082
129CDK70.42452847
130KIT0.42351021
131CSF1R0.41732413
132NLK0.41227691
133PRKD10.40616963
134MKNK10.40289618
135GRK60.40152693
136ERBB20.38949663
137PRKG20.38768298
138AKT10.38051625
139GSK3A0.37584176
140LMTK20.37295935
141CDK150.36457989
142CDK11A0.33973417
143PAK10.33310024
144MAPK10.31936499
145SGK30.31310362
146MARK10.30001630
147DAPK30.29852431
148STK240.28503769

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.33324494
2Leishmaniasis_Homo sapiens_hsa051402.31936648
3Osteoclast differentiation_Homo sapiens_hsa043802.11395591
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.07532679
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96635441
6Other glycan degradation_Homo sapiens_hsa005111.92315737
7TNF signaling pathway_Homo sapiens_hsa046681.91764283
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84700345
9Allograft rejection_Homo sapiens_hsa053301.82521058
10Chronic myeloid leukemia_Homo sapiens_hsa052201.81896870
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77202115
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74962384
13Legionellosis_Homo sapiens_hsa051341.69829673
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66808890
15Malaria_Homo sapiens_hsa051441.65138189
16Graft-versus-host disease_Homo sapiens_hsa053321.63229416
17Measles_Homo sapiens_hsa051621.60978885
18Toxoplasmosis_Homo sapiens_hsa051451.54621136
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53901563
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51950056
21B cell receptor signaling pathway_Homo sapiens_hsa046621.50290559
22T cell receptor signaling pathway_Homo sapiens_hsa046601.49908595
23Apoptosis_Homo sapiens_hsa042101.48421271
24Acute myeloid leukemia_Homo sapiens_hsa052211.47253570
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44598939
26Small cell lung cancer_Homo sapiens_hsa052221.42646434
27Herpes simplex infection_Homo sapiens_hsa051681.42446317
28Notch signaling pathway_Homo sapiens_hsa043301.41760678
29Influenza A_Homo sapiens_hsa051641.41723298
30MicroRNAs in cancer_Homo sapiens_hsa052061.41368764
31Viral myocarditis_Homo sapiens_hsa054161.40733618
32Asthma_Homo sapiens_hsa053101.36314506
33Hepatitis B_Homo sapiens_hsa051611.32941330
34Shigellosis_Homo sapiens_hsa051311.31462767
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31197771
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30895561
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.30764166
38Axon guidance_Homo sapiens_hsa043601.29552685
39Lysosome_Homo sapiens_hsa041421.29108010
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26352682
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26263495
42Tuberculosis_Homo sapiens_hsa051521.24945462
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.24832650
44Pertussis_Homo sapiens_hsa051331.21413161
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20886579
46Proteoglycans in cancer_Homo sapiens_hsa052051.20838599
47Adherens junction_Homo sapiens_hsa045201.20264645
48Salmonella infection_Homo sapiens_hsa051321.19139853
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18921364
50HTLV-I infection_Homo sapiens_hsa051661.17712780
51Pancreatic cancer_Homo sapiens_hsa052121.17563089
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.16183047
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16182891
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13458304
55Sphingolipid metabolism_Homo sapiens_hsa006001.10297083
56Colorectal cancer_Homo sapiens_hsa052101.08756318
57Staphylococcus aureus infection_Homo sapiens_hsa051501.07331424
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.05551236
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.05130842
60Amoebiasis_Homo sapiens_hsa051461.05112510
61Epstein-Barr virus infection_Homo sapiens_hsa051691.04521108
62Chemokine signaling pathway_Homo sapiens_hsa040621.04166190
63Prolactin signaling pathway_Homo sapiens_hsa049171.03719717
64Hematopoietic cell lineage_Homo sapiens_hsa046401.02838438
65Viral carcinogenesis_Homo sapiens_hsa052031.01368926
66Primary immunodeficiency_Homo sapiens_hsa053400.99100199
67Hepatitis C_Homo sapiens_hsa051600.98806377
68Endometrial cancer_Homo sapiens_hsa052130.98713497
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98382077
70Prion diseases_Homo sapiens_hsa050200.97674402
71Sulfur relay system_Homo sapiens_hsa041220.96751430
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95855761
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95838334
74TGF-beta signaling pathway_Homo sapiens_hsa043500.95418877
75Antigen processing and presentation_Homo sapiens_hsa046120.95297287
76Focal adhesion_Homo sapiens_hsa045100.93517391
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93347594
78Hedgehog signaling pathway_Homo sapiens_hsa043400.93327838
79Renal cell carcinoma_Homo sapiens_hsa052110.88253690
80Prostate cancer_Homo sapiens_hsa052150.87740585
81mTOR signaling pathway_Homo sapiens_hsa041500.86921914
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86254243
83VEGF signaling pathway_Homo sapiens_hsa043700.86058552
84Hippo signaling pathway_Homo sapiens_hsa043900.84535923
85GnRH signaling pathway_Homo sapiens_hsa049120.83784311
86Type I diabetes mellitus_Homo sapiens_hsa049400.83603389
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83529134
88Fructose and mannose metabolism_Homo sapiens_hsa000510.83371335
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82725642
90Bladder cancer_Homo sapiens_hsa052190.82340760
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81502269
92FoxO signaling pathway_Homo sapiens_hsa040680.80986369
93Inositol phosphate metabolism_Homo sapiens_hsa005620.80940593
94Estrogen signaling pathway_Homo sapiens_hsa049150.79866724
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79181310
96African trypanosomiasis_Homo sapiens_hsa051430.78479873
97MAPK signaling pathway_Homo sapiens_hsa040100.77920076
98Basal cell carcinoma_Homo sapiens_hsa052170.77510017
99HIF-1 signaling pathway_Homo sapiens_hsa040660.77234149
100Non-small cell lung cancer_Homo sapiens_hsa052230.75279655
101Autoimmune thyroid disease_Homo sapiens_hsa053200.74718532
102Glioma_Homo sapiens_hsa052140.74591170
103p53 signaling pathway_Homo sapiens_hsa041150.73567086
104Dorso-ventral axis formation_Homo sapiens_hsa043200.73354176
105Pathways in cancer_Homo sapiens_hsa052000.73214502
106Endocytosis_Homo sapiens_hsa041440.73110885
107Melanogenesis_Homo sapiens_hsa049160.72667039
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72522594
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71675615
110Rheumatoid arthritis_Homo sapiens_hsa053230.71239562
111Platelet activation_Homo sapiens_hsa046110.68344329
112Insulin resistance_Homo sapiens_hsa049310.68170593
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67639292
114ECM-receptor interaction_Homo sapiens_hsa045120.66975208
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.66754489
116Ovarian steroidogenesis_Homo sapiens_hsa049130.66367964
117Type II diabetes mellitus_Homo sapiens_hsa049300.65288113
118Gap junction_Homo sapiens_hsa045400.63844466
119ErbB signaling pathway_Homo sapiens_hsa040120.63234547
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.62568116
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61659811
122Spliceosome_Homo sapiens_hsa030400.61450440
123Ras signaling pathway_Homo sapiens_hsa040140.60429271
124Insulin signaling pathway_Homo sapiens_hsa049100.60237504
125mRNA surveillance pathway_Homo sapiens_hsa030150.59801936
126Choline metabolism in cancer_Homo sapiens_hsa052310.59540424
127Lysine degradation_Homo sapiens_hsa003100.59159416
128Melanoma_Homo sapiens_hsa052180.58368845
129Phagosome_Homo sapiens_hsa041450.56896093
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56376393
131Rap1 signaling pathway_Homo sapiens_hsa040150.56042070
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55867667
133Cell cycle_Homo sapiens_hsa041100.52413274
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.51810045

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