ZSWIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.97859417
2reproduction (GO:0000003)9.65998894
3lung morphogenesis (GO:0060425)9.58877799
4histone H3-K36 demethylation (GO:0070544)9.50627451
5retinal metabolic process (GO:0042574)9.32481320
6spermatid development (GO:0007286)9.29981530
7motile cilium assembly (GO:0044458)9.18618058
8cilium movement (GO:0003341)8.55506836
9piRNA metabolic process (GO:0034587)8.34359839
10regulation of cilium movement (GO:0003352)8.30938580
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.08191025
12male meiosis (GO:0007140)8.07545530
13platelet dense granule organization (GO:0060155)7.69748542
14regulation of histone H3-K27 methylation (GO:0061085)7.68562720
15single fertilization (GO:0007338)7.64743309
16synaptonemal complex organization (GO:0070193)7.59822001
17endothelial cell morphogenesis (GO:0001886)7.50878393
18synaptonemal complex assembly (GO:0007130)7.46695192
19sperm capacitation (GO:0048240)7.28027031
20positive regulation of mitochondrial fission (GO:0090141)6.59097066
21activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)6.51471707
22fertilization (GO:0009566)6.43977214
23spermatogenesis (GO:0007283)6.27768644
24heparin metabolic process (GO:0030202)6.27548732
25heparin biosynthetic process (GO:0030210)6.27548732
26male gamete generation (GO:0048232)6.25560736
27microtubule depolymerization (GO:0007019)6.18331613
28positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021106.17897865
29mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)6.17897865
30negative regulation of inclusion body assembly (GO:0090084)6.17073674
31positive regulation of endothelial cell apoptotic process (GO:2000353)6.00036508
32retinoic acid metabolic process (GO:0042573)5.76700617
33gamete generation (GO:0007276)5.76373853
34organic cation transport (GO:0015695)5.68869787
35regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.59993109
36mitotic cell cycle arrest (GO:0071850)5.59433900
37glucocorticoid receptor signaling pathway (GO:0042921)5.51176600
38negative regulation of histone methylation (GO:0031061)5.46911718
39ventricular system development (GO:0021591)5.46379525
40regulation of chromatin silencing (GO:0031935)5.36651124
41cellular process involved in reproduction in multicellular organism (GO:0022412)5.35971166
42DNA methylation involved in gamete generation (GO:0043046)5.33960654
43germ cell development (GO:0007281)5.25646766
44phosphorelay signal transduction system (GO:0000160)5.23986979
45male meiosis I (GO:0007141)5.22592982
46RNA destabilization (GO:0050779)5.21884512
47chromosome organization involved in meiosis (GO:0070192)5.20074704
48regulation of inclusion body assembly (GO:0090083)5.16713980
49regulation of mitochondrial fission (GO:0090140)5.16161639
50calcium ion-dependent exocytosis (GO:0017156)5.11434261
51cellular protein catabolic process (GO:0044257)5.09316743
52cell recognition (GO:0008037)5.02565831
53protein K6-linked ubiquitination (GO:0085020)4.99265552
54histone demethylation (GO:0016577)4.96756562
55microtubule severing (GO:0051013)4.94322236
56negative regulation of cAMP-mediated signaling (GO:0043951)4.90895025
57regulation of microtubule-based movement (GO:0060632)4.85827023
58regulation of protein polyubiquitination (GO:1902914)4.84203058
59mitochondrial calcium ion transport (GO:0006851)4.80059767
60meiotic nuclear division (GO:0007126)4.69759693
61negative regulation of cytosolic calcium ion concentration (GO:0051481)4.69727911
62spermatid nucleus differentiation (GO:0007289)4.64733650
63regulation of glucokinase activity (GO:0033131)4.63463861
64regulation of hexokinase activity (GO:1903299)4.63463861
65seminiferous tubule development (GO:0072520)4.60768902
66positive regulation of mitochondrial membrane permeability (GO:0035794)4.56731114
67multicellular organismal reproductive process (GO:0048609)4.53491406
68protein dealkylation (GO:0008214)4.41483721
69protein demethylation (GO:0006482)4.41483721
70dopamine transport (GO:0015872)4.40113520
71positive regulation of glomerulus development (GO:0090193)4.37346757
72monoubiquitinated protein deubiquitination (GO:0035520)4.34169504
73opioid receptor signaling pathway (GO:0038003)4.32875700
74corticosteroid receptor signaling pathway (GO:0031958)4.31826895
75regulation of apoptotic process involved in morphogenesis (GO:1902337)4.26938623
76regulation of oxidative stress-induced neuron death (GO:1903203)4.25177152
77glycerol ether metabolic process (GO:0006662)4.24047309
78positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.23928708
79meiosis I (GO:0007127)4.23498705
80negative regulation of vascular permeability (GO:0043116)4.19685833
81phagocytosis, recognition (GO:0006910)4.18410774
82negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.18343913
83left/right pattern formation (GO:0060972)4.10745096
84microtubule nucleation (GO:0007020)4.08001069
85startle response (GO:0001964)4.06580359
86cellular response to vitamin D (GO:0071305)4.03030566
87cellular ketone body metabolic process (GO:0046950)4.01202189
88lateral sprouting from an epithelium (GO:0060601)3.98124576
89chromosome condensation (GO:0030261)3.95452363
90ether metabolic process (GO:0018904)3.91629795
91regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.85770571
92sprouting angiogenesis (GO:0002040)3.85131206
93establishment of apical/basal cell polarity (GO:0035089)3.82543470
94protein polyglutamylation (GO:0018095)3.81222357
95genitalia morphogenesis (GO:0035112)3.77172335
96protein localization to cilium (GO:0061512)3.76597176
97DNA packaging (GO:0006323)3.76523474
98meiotic cell cycle (GO:0051321)3.75740453
99mRNA cleavage (GO:0006379)3.75430837
100regulation of vitamin D biosynthetic process (GO:0060556)3.73540328
101chaperone-mediated protein complex assembly (GO:0051131)3.72727636
102positive regulation of keratinocyte differentiation (GO:0045618)3.72466943
103protein destabilization (GO:0031648)3.70179783
104cellular response to ammonium ion (GO:0071242)3.69880114
105multicellular organismal development (GO:0007275)3.66224510
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.59521834
107negative regulation of telomere maintenance (GO:0032205)3.57405966
108negative regulation of macroautophagy (GO:0016242)3.54192024
109ketone body metabolic process (GO:1902224)3.53682024
110coenzyme catabolic process (GO:0009109)3.53516033
111regulation of endothelial cell apoptotic process (GO:2000351)3.52759453
112regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.52167127
113regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.50643753
114regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.49845777
115establishment or maintenance of monopolar cell polarity (GO:0061339)3.48332013
116establishment of monopolar cell polarity (GO:0061162)3.48332013
117blood vessel endothelial cell migration (GO:0043534)3.41391202
118zinc ion homeostasis (GO:0055069)3.37336535
119positive regulation of extracellular matrix organization (GO:1903055)3.37144802
120protein K11-linked deubiquitination (GO:0035871)3.32831825
121mannosylation (GO:0097502)3.32334128
122secretory granule organization (GO:0033363)3.31098641
123intraciliary transport (GO:0042073)3.29613742
124histone lysine demethylation (GO:0070076)3.27337322
125regulation of spindle checkpoint (GO:0090231)3.25498086
126glucocorticoid metabolic process (GO:0008211)3.24668565
127microtubule polymerization or depolymerization (GO:0031109)3.22096937
128negative regulation of osteoblast differentiation (GO:0045668)3.21833053
129single strand break repair (GO:0000012)3.19777262
130fatty acid transmembrane transport (GO:1902001)3.19013377
131axoneme assembly (GO:0035082)3.15998670
132amino-acid betaine transport (GO:0015838)3.15985960
133carnitine transport (GO:0015879)3.15985960
134negative regulation of keratinocyte proliferation (GO:0010839)3.15711422
135behavioral response to ethanol (GO:0048149)3.15457845
136vasculature development (GO:0001944)3.14386693
137protein localization to cell surface (GO:0034394)3.14084219
138response to manganese ion (GO:0010042)3.13362167
139anterograde synaptic vesicle transport (GO:0048490)3.13358656
140synapsis (GO:0007129)3.11587180
141norepinephrine metabolic process (GO:0042415)3.11231623
142meiotic cell cycle process (GO:1903046)3.11034707
143microtubule-based movement (GO:0007018)3.10185077
144negative regulation of dendrite morphogenesis (GO:0050774)3.09273279
145endoderm formation (GO:0001706)3.09084059
146cellular response to fluid shear stress (GO:0071498)3.08987871
147synaptic transmission, cholinergic (GO:0007271)3.08713142
148negative regulation of DNA binding (GO:0043392)3.07660523
149carnitine transmembrane transport (GO:1902603)3.07398874
150gene silencing by RNA (GO:0031047)3.06984591
151neurotransmitter uptake (GO:0001504)3.06020492
152cilium organization (GO:0044782)3.05039614
153polyol catabolic process (GO:0046174)3.04383188
154regulation of female gonad development (GO:2000194)3.03058768
155negative regulation of organelle assembly (GO:1902116)3.02401947
156sexual reproduction (GO:0019953)3.02068340
157sequestering of actin monomers (GO:0042989)3.02048574
158nucleoside diphosphate phosphorylation (GO:0006165)3.00584145
159regulation of dopamine secretion (GO:0014059)2.99964201
160cellular response to nutrient (GO:0031670)2.99078812
161alditol metabolic process (GO:0019400)2.97460932
162mitotic sister chromatid cohesion (GO:0007064)2.92690055
163cilium assembly (GO:0042384)2.91256754
164protein refolding (GO:0042026)2.90598173
165cellular component assembly involved in morphogenesis (GO:0010927)2.89313846
166nucleus organization (GO:0006997)2.87535397
167glycolytic process (GO:0006096)2.87384633
168cilium morphogenesis (GO:0060271)2.85738659
169GTP biosynthetic process (GO:0006183)2.82681016
170lactate metabolic process (GO:0006089)2.80901439
171regulation of centriole replication (GO:0046599)2.79602831
172centriole assembly (GO:0098534)2.79013024
173nuclear pore complex assembly (GO:0051292)2.74849722
174centriole replication (GO:0007099)2.61591307
175glycerol metabolic process (GO:0006071)2.57369651
176peptidyl-glutamic acid modification (GO:0018200)2.55428988
177interferon-gamma secretion (GO:0072643)2.54258090
178UTP biosynthetic process (GO:0006228)2.51882029
179regulation of meiosis I (GO:0060631)2.48959199
180positive regulation of macrophage activation (GO:0043032)2.44471248
181fusion of sperm to egg plasma membrane (GO:0007342)14.0001419
182sperm motility (GO:0030317)13.0634916
183acrosome assembly (GO:0001675)12.3097069
184cell wall macromolecule catabolic process (GO:0016998)12.1939477
185cell wall macromolecule metabolic process (GO:0044036)12.1939477
186cilium or flagellum-dependent cell motility (GO:0001539)12.0685634
187sperm-egg recognition (GO:0035036)11.6124268
188multicellular organism reproduction (GO:0032504)11.5569333
189acrosome reaction (GO:0007340)11.1470475
190plasma membrane fusion (GO:0045026)10.6754347
191lung vasculature development (GO:0060426)10.5498022
192binding of sperm to zona pellucida (GO:0007339)10.4921736
193cell-cell recognition (GO:0009988)10.3966924
194axonemal dynein complex assembly (GO:0070286)10.3840911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.02579599
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.22636139
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.06749105
4GATA1_22025678_ChIP-Seq_K562_Human4.96292912
5EZH2_22144423_ChIP-Seq_EOC_Human4.39356379
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.71529034
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.53165408
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.03874019
9ESR1_15608294_ChIP-ChIP_MCF-7_Human2.88800337
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.67908898
11FUS_26573619_Chip-Seq_HEK293_Human2.64832227
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47758771
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.46558740
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.41927979
15IRF1_19129219_ChIP-ChIP_H3396_Human2.28252682
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19581957
17VDR_22108803_ChIP-Seq_LS180_Human2.17219424
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.17171131
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15735985
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11934973
21ER_23166858_ChIP-Seq_MCF-7_Human2.10040935
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.09769867
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06855028
24ZNF274_21170338_ChIP-Seq_K562_Hela2.02506448
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1147479
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.97565639
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.95267236
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.93901886
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.91305278
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.88935299
31KAP1_22055183_ChIP-Seq_ESCs_Mouse1.88135354
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.84177061
33* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.80535415
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.80409815
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.80231046
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79081966
37AR_21572438_ChIP-Seq_LNCaP_Human1.76316796
38STAT1_17558387_ChIP-Seq_HELA_Human1.74014641
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71440319
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.70464009
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.69158715
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64397807
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63127692
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.61713177
45AHR_22903824_ChIP-Seq_MCF-7_Human1.59517572
46P53_22127205_ChIP-Seq_FIBROBLAST_Human1.58033809
47FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57474407
48KDM2B_26808549_Chip-Seq_REH_Human1.54620990
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.53299371
50AR_25329375_ChIP-Seq_VCAP_Human1.53181065
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.52605267
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.52500677
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51400719
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.46452347
55* P300_19829295_ChIP-Seq_ESCs_Human1.46406815
56GATA3_21867929_ChIP-Seq_CD8_Mouse1.45990412
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44781213
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44455957
59CBP_20019798_ChIP-Seq_JUKART_Human1.44455957
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41621020
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.39100229
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.37509228
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36347421
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35777777
65* NANOG_19829295_ChIP-Seq_ESCs_Human1.34759441
66* SOX2_19829295_ChIP-Seq_ESCs_Human1.34759441
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.34594817
68CJUN_26792858_Chip-Seq_BT549_Human1.34010870
69SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.33360588
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.32630252
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32059189
72GATA3_21867929_ChIP-Seq_TH1_Mouse1.31075948
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29768858
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29327968
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26785330
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24283695
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.23942489
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23663846
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.23408736
80REST_21632747_ChIP-Seq_MESCs_Mouse1.20613047
81RNF2_27304074_Chip-Seq_NSC_Mouse1.20040283
82P53_21459846_ChIP-Seq_SAOS-2_Human1.19887340
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18706985
84FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18523498
85* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18055339
86GF1_26923725_Chip-Seq_HPCs_Mouse1.17413671
87RUNX1_26923725_Chip-Seq_HPCs_Mouse1.16172139
88CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16134959
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15706561
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15706561
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15281902
92OCT4_20526341_ChIP-Seq_ESCs_Human1.15148143
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14878122
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14628301
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14410147
96OCT4_18555785_Chip-Seq_ESCs_Mouse1.14313666
97* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13256459
98* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12915629
99AR_20517297_ChIP-Seq_VCAP_Human1.12823802
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12721698
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.12375626
102DROSHA_22980978_ChIP-Seq_HELA_Human1.11139945
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10121615
104* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09791741
105TAF15_26573619_Chip-Seq_HEK293_Human1.08427530
106* P53_22387025_ChIP-Seq_ESCs_Mouse1.06681172
107* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06519743
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.06217403
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05879134
110FOXH1_21741376_ChIP-Seq_EPCs_Human1.05692819
111SPI1_26923725_Chip-Seq_HPCs_Mouse1.04952785
112P300_18555785_Chip-Seq_ESCs_Mouse1.04875225
113* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04388890
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04344884
115ERG_20517297_ChIP-Seq_VCAP_Human1.03718089
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.03447570
117* STAT3_23295773_ChIP-Seq_U87_Human1.03213472
118NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02889659
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02712414
120* CDX2_20551321_ChIP-Seq_CACO-2_Human1.02658767
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02492177
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01935218
123CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01657127
124ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01080719
125REST_18959480_ChIP-ChIP_MESCs_Mouse1.01062281
126RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00850310
127* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00648805
128ESET_19884257_ChIP-Seq_ESCs_Mouse0.99213323
129SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98308176
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97662176
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97366567
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97262588
133STAT3_18555785_Chip-Seq_ESCs_Mouse0.96681458
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94824530
135ELF1_20517297_ChIP-Seq_JURKAT_Human0.93436267
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93069468
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.93063891
138ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92919821
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92633098
140GATA3_21878914_ChIP-Seq_MCF-7_Human0.92341135
141LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92027863
142SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92004687
143GF1B_26923725_Chip-Seq_HPCs_Mouse0.91965608
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91120234
145GATA3_26560356_Chip-Seq_TH2_Human0.91059303
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90537449
147P300_27268052_Chip-Seq_Bcells_Human0.90426280
148STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89994489
149SOX9_26525672_Chip-Seq_HEART_Mouse0.89955585
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.89572041
151KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89346647
152KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89346647
153KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89346647
154TP53_22573176_ChIP-Seq_HFKS_Human0.89282122
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89154244
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88919856
157GATA2_19941826_ChIP-Seq_K562_Human0.88809179
158MYC_27129775_Chip-Seq_CORNEA_Mouse0.88266831
159SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88067255
160FLI1_21867929_ChIP-Seq_CD8_Mouse0.87996466
161CTCF_18555785_Chip-Seq_ESCs_Mouse0.87549514
162NFYB_21822215_ChIP-Seq_K562_Human0.87476899
163PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87091915
164TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87071706
165HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86356669
166GBX2_23144817_ChIP-Seq_PC3_Human0.85998317
167* TCF4_23295773_ChIP-Seq_U87_Human0.85940265
168EP300_21415370_ChIP-Seq_HL-1_Mouse0.85937952
169TP53_22127205_ChIP-Seq_IMR90_Human0.85651766
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.84816484
171ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84279794
172ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83902788
173NANOG_16153702_ChIP-ChIP_HESCs_Human0.83260821
174CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82941417
175VDR_24787735_ChIP-Seq_THP-1_Human0.82690949
176SOX2_16153702_ChIP-ChIP_HESCs_Human0.82403700
177JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82207048
178RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82022670
179EED_16625203_ChIP-ChIP_MESCs_Mouse0.81971813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08353913
2MP0001929_abnormal_gametogenesis5.59804548
3MP0008877_abnormal_DNA_methylation4.69563609
4MP0005645_abnormal_hypothalamus_physiol4.05386639
5MP0002210_abnormal_sex_determination3.63850740
6MP0003828_pulmonary_edema3.62946223
7MP0001968_abnormal_touch/_nociception3.40664935
8MP0002161_abnormal_fertility/fecundity3.31259721
9MP0001145_abnormal_male_reproductive3.08685137
10MP0002653_abnormal_ependyma_morphology3.05131400
11MP0003279_aneurysm2.76772320
12MP0000653_abnormal_sex_gland2.70419623
13MP0001486_abnormal_startle_reflex2.54231489
14MP0003300_gastrointestinal_ulcer2.51021828
15MP0005646_abnormal_pituitary_gland2.47046613
16MP0000678_abnormal_parathyroid_gland2.32576548
17MP0000537_abnormal_urethra_morphology2.26780044
18MP0005670_abnormal_white_adipose2.20427307
19MP0009053_abnormal_anal_canal2.16460686
20MP0005623_abnormal_meninges_morphology2.12525177
21MP0005167_abnormal_blood-brain_barrier2.11426921
22MP0004130_abnormal_muscle_cell2.08898002
23MP0000013_abnormal_adipose_tissue2.07097935
24MP0005410_abnormal_fertilization15.9182035
25MP0009333_abnormal_splenocyte_physiolog1.97910970
26MP0000467_abnormal_esophagus_morphology1.81995496
27MP0001853_heart_inflammation1.81113175
28MP0002160_abnormal_reproductive_system1.71627569
29MP0004185_abnormal_adipocyte_glucose1.70567401
30MP0003646_muscle_fatigue1.61166234
31MP0008875_abnormal_xenobiotic_pharmacok1.51596139
32MP0001501_abnormal_sleep_pattern1.50555149
33MP0001919_abnormal_reproductive_system1.50412862
34MP0010368_abnormal_lymphatic_system1.47118841
35MP0001502_abnormal_circadian_rhythm1.44345680
36MP0009745_abnormal_behavioral_response1.40534832
37MP0008058_abnormal_DNA_repair1.38243704
38MP0005076_abnormal_cell_differentiation1.35611691
39MP0002282_abnormal_trachea_morphology1.33954258
40MP0008057_abnormal_DNA_replication1.27461982
41MP0001175_abnormal_lung_morphology1.25270733
42MP0002272_abnormal_nervous_system1.23029068
43MP0009046_muscle_twitch1.20026765
44MP0004215_abnormal_myocardial_fiber1.19161666
45MP0004233_abnormal_muscle_weight1.18098110
46MP0000015_abnormal_ear_pigmentation1.14369880
47MP0008872_abnormal_physiological_respon1.09457412
48MP0005647_abnormal_sex_gland1.09030273
49MP0009764_decreased_sensitivity_to1.07809243
50MP0001765_abnormal_ion_homeostasis1.07009215
51MP0002572_abnormal_emotion/affect_behav1.06805939
52MP0010329_abnormal_lipoprotein_level1.06474398
53MP0001984_abnormal_olfaction1.01943374
54MP0003943_abnormal_hepatobiliary_system1.00212885
55MP0010094_abnormal_chromosome_stability0.99447256
56MP0008995_early_reproductive_senescence0.99089755
57MP0002557_abnormal_social/conspecific_i0.94075111
58MP0005389_reproductive_system_phenotype0.87059056
59MP0001905_abnormal_dopamine_level0.86518449
60MP0004270_analgesia0.86197918
61MP0000003_abnormal_adipose_tissue0.86033093
62MP0003195_calcinosis0.84481258
63MP0000383_abnormal_hair_follicle0.82728985
64MP0003638_abnormal_response/metabolism_0.80270627
65MP0003567_abnormal_fetal_cardiomyocyte0.76738039
66MP0002063_abnormal_learning/memory/cond0.76669479
67MP0003011_delayed_dark_adaptation0.75770797
68MP0003635_abnormal_synaptic_transmissio0.75428398
69MP0003718_maternal_effect0.74456164
70MP0004947_skin_inflammation0.74136363
71MP0002295_abnormal_pulmonary_circulatio0.74084928
72MP0008873_increased_physiological_sensi0.73286214
73MP0001756_abnormal_urination0.69579158
74MP0004043_abnormal_pH_regulation0.67956419
75MP0001243_abnormal_dermal_layer0.67729448
76MP0008007_abnormal_cellular_replicative0.67318741
77MP0001191_abnormal_skin_condition0.66791719
78MP0005375_adipose_tissue_phenotype0.65767471
79MP0003786_premature_aging0.65657290
80MP0000470_abnormal_stomach_morphology0.65294653
81MP0002277_abnormal_respiratory_mucosa0.61378558
82MP0000249_abnormal_blood_vessel0.61213668
83MP0002733_abnormal_thermal_nociception0.60746844
84MP0004147_increased_porphyrin_level0.60015415
85MP0004085_abnormal_heartbeat0.59717286
86MP0003880_abnormal_central_pattern0.58410472
87MP0001440_abnormal_grooming_behavior0.57662423
88MP0002098_abnormal_vibrissa_morphology0.57547071
89MP0004858_abnormal_nervous_system0.57229155
90MP0003699_abnormal_female_reproductive0.56164872
91MP0005636_abnormal_mineral_homeostasis0.55956072
92MP0003878_abnormal_ear_physiology0.55233972
93MP0005377_hearing/vestibular/ear_phenot0.55233972
94MP0003111_abnormal_nucleus_morphology0.54889664
95MP0000377_abnormal_hair_follicle0.54761368
96MP0003115_abnormal_respiratory_system0.54453237
97MP0000358_abnormal_cell_content/0.54064333
98MP0003950_abnormal_plasma_membrane0.53802927
99MP0001664_abnormal_digestion0.52513648
100MP0003122_maternal_imprinting0.51453644
101MP0002102_abnormal_ear_morphology0.51358045
102MP0001545_abnormal_hematopoietic_system0.51011857
103MP0005397_hematopoietic_system_phenotyp0.51011857
104MP0002234_abnormal_pharynx_morphology0.50902511
105MP0000569_abnormal_digit_pigmentation0.50251611
106MP0009765_abnormal_xenobiotic_induced0.49564249
107MP0002928_abnormal_bile_duct0.48699944
108MP0010307_abnormal_tumor_latency0.47018901
109MP0001293_anophthalmia0.45642172
110MP0001324_abnormal_eye_pigmentation0.45134696
111MP0001119_abnormal_female_reproductive0.44608056
112MP0004036_abnormal_muscle_relaxation0.44088063
113MP0005666_abnormal_adipose_tissue0.40421049
114MP0005551_abnormal_eye_electrophysiolog0.40120794
115MP0005253_abnormal_eye_physiology0.39920595
116MP0001730_embryonic_growth_arrest0.38811953
117MP0003329_amyloid_beta_deposits0.37054267
118MP0009278_abnormal_bone_marrow0.37007668
119MP0001764_abnormal_homeostasis0.36916755
120MP0004808_abnormal_hematopoietic_stem0.34713629
121MP0004019_abnormal_vitamin_homeostasis0.34601357
122MP0006036_abnormal_mitochondrial_physio0.32776658
123MP0002269_muscular_atrophy0.32624246
124MP0004134_abnormal_chest_morphology0.32257789
125MP0003077_abnormal_cell_cycle0.32226079
126MP0005391_vision/eye_phenotype0.31882190
127MP0002971_abnormal_brown_adipose0.30052111
128MP0009115_abnormal_fat_cell0.29838774
129MP0003861_abnormal_nervous_system0.27871725
130MP0001661_extended_life_span0.25462330
131MP0003633_abnormal_nervous_system0.25158132
132MP0001727_abnormal_embryo_implantation0.24634364
133MP0000313_abnormal_cell_death0.24593799
134MP0002084_abnormal_developmental_patter0.24445610
135MP0004133_heterotaxia0.23770210
136MP0002152_abnormal_brain_morphology0.22979336
137MP0003879_abnormal_hair_cell0.21850408
138MP0002736_abnormal_nociception_after0.21324519
139MP0003631_nervous_system_phenotype0.21300190
140MP0006072_abnormal_retinal_apoptosis0.20605409
141MP0004811_abnormal_neuron_physiology0.19922983
142MP0002169_no_abnormal_phenotype0.19556767
143MP0002873_normal_phenotype0.19254683
144MP0001672_abnormal_embryogenesis/_devel0.18429288
145MP0005380_embryogenesis_phenotype0.18429288
146MP0000534_abnormal_ureter_morphology0.18276360
147MP0001697_abnormal_embryo_size0.18125626
148MP0002092_abnormal_eye_morphology0.17768226
149MP0001849_ear_inflammation0.17680965
150MP0003948_abnormal_gas_homeostasis0.17627293
151MP0002132_abnormal_respiratory_system0.17561357
152MP0003787_abnormal_imprinting0.17070917
153MP0001986_abnormal_taste_sensitivity0.16875592
154MP0000604_amyloidosis0.15785642
155MP0005195_abnormal_posterior_eye0.14589906
156MP0002405_respiratory_system_inflammati0.14489235
157MP0004145_abnormal_muscle_electrophysio0.14241000
158MP0000432_abnormal_head_morphology0.14239920
159MP0003045_fibrosis0.14010242
160MP0005266_abnormal_metabolism0.13827689
161MP0000001_mammalian_phenotype0.13568510
162MP0004742_abnormal_vestibular_system0.12691301
163MP0003942_abnormal_urinary_system0.12372194
164MP0002085_abnormal_embryonic_tissue0.12151662
165MP0002080_prenatal_lethality0.12046582
166MP0002229_neurodegeneration0.12012276

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.73586161
2Abnormal respiratory motile cilium morphology (HP:0005938)9.24060058
3Abnormal respiratory epithelium morphology (HP:0012253)9.24060058
4Rhinitis (HP:0012384)7.97407508
5Abnormal ciliary motility (HP:0012262)7.95628008
6Type II lissencephaly (HP:0007260)7.60798502
7Chronic bronchitis (HP:0004469)7.44892099
8Infertility (HP:0000789)6.45550320
9Nasal polyposis (HP:0100582)6.29542818
10Abnormality of the costochondral junction (HP:0000919)5.90846441
11Abnormality of the nasal mucosa (HP:0000433)5.17571525
12Bronchiectasis (HP:0002110)4.59899474
13Bronchitis (HP:0012387)4.59015379
14Cerebellar dysplasia (HP:0007033)4.40392877
15Nephronophthisis (HP:0000090)4.33624016
16Retinal dysplasia (HP:0007973)4.28168047
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.16265981
18Male infertility (HP:0003251)4.14630313
19Anterior segment dysgenesis (HP:0007700)3.86183236
20Asplenia (HP:0001746)3.66900796
21Febrile seizures (HP:0002373)3.66866103
22Aplasia/Hypoplasia of the spleen (HP:0010451)3.63454862
23Recurrent sinusitis (HP:0011108)3.63140709
24Thin bony cortex (HP:0002753)3.54651935
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.46880158
26Atonic seizures (HP:0010819)3.45853567
27Abnormal spermatogenesis (HP:0008669)3.43516344
28Pancreatic cysts (HP:0001737)3.43289692
29Delayed epiphyseal ossification (HP:0002663)3.40812796
30Enlarged epiphyses (HP:0010580)3.39946429
31Recurrent otitis media (HP:0000403)3.32949284
32Symptomatic seizures (HP:0011145)3.28863919
33Abnormality of the renal medulla (HP:0100957)3.28713716
34Abnormality of fatty-acid metabolism (HP:0004359)3.26167238
35Generalized aminoaciduria (HP:0002909)3.25168529
36Cerebral hypomyelination (HP:0006808)3.17086923
37Congenital sensorineural hearing impairment (HP:0008527)3.13283383
38Natal tooth (HP:0000695)3.06952806
39Abnormality of the proximal phalanges of the hand (HP:0009834)3.03523684
40Delayed CNS myelination (HP:0002188)2.96443060
41Enlarged kidneys (HP:0000105)2.90981800
42Lissencephaly (HP:0001339)2.87408075
43Fused cervical vertebrae (HP:0002949)2.84374547
44Optic nerve hypoplasia (HP:0000609)2.80584178
45Tubulointerstitial nephritis (HP:0001970)2.79037749
46Hypoglycemic coma (HP:0001325)2.77788062
47Widely patent fontanelles and sutures (HP:0004492)2.75675288
48Molar tooth sign on MRI (HP:0002419)2.75067143
49Abnormality of midbrain morphology (HP:0002418)2.75067143
50Postural instability (HP:0002172)2.71086908
51Recurrent bronchitis (HP:0002837)2.68430900
52Hypoplasia of the brainstem (HP:0002365)2.68190368
53Aplasia/Hypoplasia of the brainstem (HP:0007362)2.68190368
54Medial flaring of the eyebrow (HP:0010747)2.63007222
55Synostosis involving the elbow (HP:0003938)2.58346394
56Humeroradial synostosis (HP:0003041)2.58346394
57Short 1st metacarpal (HP:0010034)2.57872595
58Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.57872595
59Severe muscular hypotonia (HP:0006829)2.57673328
60Pseudobulbar signs (HP:0002200)2.57283859
61Pachygyria (HP:0001302)2.56856859
62Personality changes (HP:0000751)2.56551264
63Abnormality of the middle phalanges of the toes (HP:0010183)2.54485766
64Partial agenesis of the corpus callosum (HP:0001338)2.53637058
65Tubular atrophy (HP:0000092)2.51661245
66Facial shape deformation (HP:0011334)2.48665969
67Potter facies (HP:0002009)2.48665969
68Morphological abnormality of the middle ear (HP:0008609)2.48609888
69Abnormality of the nasal septum (HP:0000419)2.48091449
70Gonadotropin excess (HP:0000837)2.47369588
71Alveolar cell carcinoma (HP:0006519)2.46383403
72Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.45954597
73Impulsivity (HP:0100710)2.42669090
74Azoospermia (HP:0000027)2.42568859
75Renal cortical cysts (HP:0000803)2.42490528
76Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.40747243
77Tubulointerstitial abnormality (HP:0001969)2.39143706
78Epileptic encephalopathy (HP:0200134)2.37074295
79Fibular aplasia (HP:0002990)2.34652458
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.33449789
81Abnormality of the lower motor neuron (HP:0002366)2.32487255
82Occipital encephalocele (HP:0002085)2.30359047
83Absent phalangeal crease (HP:0006109)2.28988246
84Abnormality of the 1st metacarpal (HP:0010009)2.28229071
85Clumsiness (HP:0002312)2.25026279
86Status epilepticus (HP:0002133)2.23497205
87Absence seizures (HP:0002121)2.20123108
88Abnormality of the phalanges of the 5th finger (HP:0004213)2.19831034
89Long nose (HP:0003189)2.19527507
90Aplasia/hypoplasia of the humerus (HP:0006507)2.19250670
91Cortical visual impairment (HP:0100704)2.18379478
92Increased corneal curvature (HP:0100692)2.17914145
93Keratoconus (HP:0000563)2.17914145
94Neurofibrillary tangles (HP:0002185)2.15905615
95Adrenal hypoplasia (HP:0000835)2.13814658
96Metaphyseal irregularity (HP:0003025)2.12982872
97Chronic otitis media (HP:0000389)2.12773656
98Neoplasm of the tracheobronchial system (HP:0100552)2.12536220
99Symphalangism affecting the phalanges of the hand (HP:0009773)2.10295474
100Chorioretinal atrophy (HP:0000533)2.09180897
101Metabolic alkalosis (HP:0200114)2.08808189
102Polymicrogyria (HP:0002126)2.07500633
103Unsteady gait (HP:0002317)2.07185752
104Abnormality of the distal phalanges of the toes (HP:0010182)2.06891939
105Postaxial foot polydactyly (HP:0001830)2.01028762
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7473848
107Dynein arm defect of respiratory motile cilia (HP:0012255)13.0096850
108Absent/shortened dynein arms (HP:0200106)13.0096850
109Non-midline cleft lip (HP:0100335)1.99841338
110Breech presentation (HP:0001623)1.98488942
111Polyuria (HP:0000103)1.97781338
112Hypoplasia of the pons (HP:0012110)1.96440133
113Abnormality of the pons (HP:0007361)1.94303385
114Fibular hypoplasia (HP:0003038)1.94226587
115Tubulointerstitial fibrosis (HP:0005576)1.92566852
116Abnormality of dental color (HP:0011073)1.90808735
117Abnormality of calcium-phosphate metabolism (HP:0100530)1.88337291
118Amyotrophic lateral sclerosis (HP:0007354)1.88052532
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.87867215
120Delusions (HP:0000746)1.86625868
121Carpal bone hypoplasia (HP:0001498)1.85749100
122Congenital hepatic fibrosis (HP:0002612)1.85267975
123Single umbilical artery (HP:0001195)1.84646813
124Stage 5 chronic kidney disease (HP:0003774)1.82478359
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80985502
126Dyschromatopsia (HP:0007641)1.79933569
127Microglossia (HP:0000171)1.76296599
128Abnormality of the renal cortex (HP:0011035)1.76189089
129Abnormal drinking behavior (HP:0030082)1.74657787
130Polydipsia (HP:0001959)1.74657787
131Abnormality of dentin (HP:0010299)1.73498786
132Short ribs (HP:0000773)1.70837106
133Pancreatic fibrosis (HP:0100732)1.69203448
134Cholecystitis (HP:0001082)1.68844304
135Abnormal gallbladder physiology (HP:0012438)1.68844304
136Spastic tetraparesis (HP:0001285)1.64728179
137Chronic sinusitis (HP:0011109)1.63463351
138Decreased central vision (HP:0007663)1.63196619
139Abnormality of permanent molar morphology (HP:0011071)1.62821866
140Abnormality of the dental root (HP:0006486)1.62821866
141Taurodontia (HP:0000679)1.62821866
142Oculomotor apraxia (HP:0000657)1.62560774
143Abnormality of the dental pulp (HP:0006479)1.60421794
144Renal dysplasia (HP:0000110)1.59478072
145Absent frontal sinuses (HP:0002688)1.59469658
146Heterotopia (HP:0002282)1.58535555
147Facial cleft (HP:0002006)1.57043459
148Abnormality of renal excretion (HP:0011036)1.55736376
149J-shaped sella turcica (HP:0002680)1.55093304
150Postaxial hand polydactyly (HP:0001162)1.54680907
151Congenital primary aphakia (HP:0007707)1.53786355
152Impaired proprioception (HP:0010831)1.53504245
153Gait imbalance (HP:0002141)1.53422229
154Abnormality of molar morphology (HP:0011070)1.51950337
155Abnormality of molar (HP:0011077)1.51950337
156Cystic liver disease (HP:0006706)1.51545079
157Abnormal biliary tract physiology (HP:0012439)1.49469944
158Bile duct proliferation (HP:0001408)1.49469944
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.48889848
160Supernumerary spleens (HP:0009799)1.43875219
161Aplasia/Hypoplasia of the lens (HP:0008063)1.42838809
162Choroideremia (HP:0001139)1.41764284
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41647564
164Absent epiphyses (HP:0010577)1.41647564
165Bell-shaped thorax (HP:0001591)1.39295783
166Median cleft lip (HP:0000161)1.36481187
167Deformed sella turcica (HP:0002681)1.33036842
168Nephrogenic diabetes insipidus (HP:0009806)1.29889063
169Short thorax (HP:0010306)1.28324538
170Upper motor neuron abnormality (HP:0002127)1.28284133
171True hermaphroditism (HP:0010459)1.26484906
172Aplasia/Hypoplasia of the fibula (HP:0006492)1.25340360
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24812064
174Nephropathy (HP:0000112)1.22949768
175Abnormal urine output (HP:0012590)1.22186897
176Poor coordination (HP:0002370)1.20735701
177Abnormality of ocular smooth pursuit (HP:0000617)1.20303312
178Genital tract atresia (HP:0001827)1.19629361
179Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.18059164
180Broad distal phalanx of finger (HP:0009836)1.17208615
181Asymmetric septal hypertrophy (HP:0001670)1.17000367
182Abnormality of the anterior horn cell (HP:0006802)1.15791535
183Degeneration of anterior horn cells (HP:0002398)1.15791535
184Hemorrhage of the eye (HP:0011885)1.15731366
185Breast carcinoma (HP:0003002)1.15399227
186Vaginal atresia (HP:0000148)1.14908260
187Abnormality of saccadic eye movements (HP:0000570)1.11621286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.76542234
2PDK48.76542234
3PDK25.86706756
4TESK15.10897192
5PRKD34.33056164
6SRPK14.20141119
7ERN13.47357221
8TIE13.44232886
9ICK3.41318247
10ADRBK23.33024187
11DYRK23.32818156
12TAOK33.06429044
13HIPK22.60312821
14PTK2B2.38863289
15WNK42.30866189
16PNCK2.20335574
17STK392.19535360
18NEK21.81692493
19STK381.62305357
20GRK11.61886482
21GRK71.58565183
22NTRK11.41979680
23MOS1.38644239
24DAPK21.35409684
25ADRBK11.18667831
26DYRK1B1.14353365
27PDK11.12210647
28MAP2K21.11288414
29GRK51.07931636
30NME11.03279093
31TGFBR21.00407080
32DYRK30.96366825
33TYRO30.94858774
34EIF2AK20.93476108
35WNK10.90616971
36STK30.84104630
37CCNB10.81762417
38ITK0.78457710
39TTK0.78228689
40RPS6KA20.77916925
41MAPK150.77902028
42MATK0.75707214
43TAF10.75457279
44PIK3CA0.75017631
45PASK0.74769470
46ERBB30.74110030
47FLT30.73088114
48MAPK110.70017035
49WEE10.69913434
50RIPK10.69525974
51CHEK20.68186348
52CSNK1A10.65806027
53VRK10.65438231
54STK38L0.64117225
55IRAK10.63958465
56CDC70.63776322
57TRPM70.60113801
58LMTK20.57924405
59PDPK10.57856750
60CAMK1G0.54572398
61BRSK20.52095558
62RPS6KL10.51354600
63RPS6KC10.51354600
64ABL20.51188284
65CHEK10.50921522
66TESK20.50763636
67RPS6KA60.50283222
68VRK20.47164546
69PLK40.45693397
70MAP2K60.45223437
71PINK10.44825820
72INSRR0.44617217
73MAPK130.43986263
74PRKCE0.43739095
75EEF2K0.43496213
76IGF1R0.43061207
77MUSK0.41875627
78ATR0.40776782
79CAMK40.39456825
80NEK60.38820003
81MAP3K70.38777180
82MAPK40.37526976
83ATM0.36385431
84RIPK40.35563592
85SYK0.34873768
86PLK20.34490743
87PAK10.33957406
88PLK10.33715834
89MET0.33513983
90NTRK20.30849042
91PRKCI0.29932490
92IRAK20.27622593
93CHUK0.26002770
94PRKCG0.24814322
95CDK50.23932047
96MTOR0.23775703
97MAP4K20.23488044
98PRKAA10.23267199
99PAK20.22443961
100BRSK10.21711609
101DDR20.21604670
102MAP2K70.21500337
103IKBKB0.21147356
104MARK30.20614745
105CDK120.19849010
106MAP3K40.19473487
107RPS6KB10.18916248
108BCKDK0.18886520
109TGFBR10.18403934
110CAMKK10.18352259
111AKT10.18210993
112MAP3K140.18069624
113FRK0.17775570
114MARK10.17526207
115MAPKAPK50.17228924
116BMPR1B0.15858569
117ERBB20.15497628
118ABL10.15350392
119MAPK70.14370109
120MARK20.14199787
121SIK20.14158627
122CAMK10.13073066
123MELK0.12474679
124ARAF0.12113048
125RPS6KA50.12066657
126MAPKAPK30.11523634
127MAP2K10.11088612
128SMG10.10791204
129MAP3K100.10493053
130PRKACA0.10314259
131LATS10.09905683
132CSNK2A10.09418964
133CDK30.09139162
134PRKCQ0.08808393
135CDK10.08086049
136WNK30.08081220
137PRKCZ0.08006927
138CDK20.07905315
139GSK3B0.07158396
140ZAP700.06892464
141CDK150.06622267
142AURKA0.06281354
143PRKG10.05568209
144BRAF0.05467899
145CSNK2A20.04793086
146CSNK1D0.04696709
147PKN10.04552617
148CDK180.04189438
149STK100.03997512
150STK110.03545517
151CDK11A0.03428525
152PAK40.02964410
153MAPK80.02637930
154PRKACG0.02620737
155CAMK2A0.02575963
156PAK60.02077206
157CDK40.01873846
158MAP3K50.01318236
159RPS6KA10.01270076
160CDK140.01033056
161PRKDC0.00805537
162CDK60.00617027
163PDGFRB0.00049793
164AURKB-0.0241608
165EGFR-0.0202578
166MAPK10-0.0135809
167PRKCB-0.0092736
168PRKACB-0.0089990
169PRKG2-0.0086498

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.71694648
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.21365107
3Fatty acid biosynthesis_Homo sapiens_hsa000613.77216780
4Pyruvate metabolism_Homo sapiens_hsa006203.73962640
5Non-homologous end-joining_Homo sapiens_hsa034503.35174608
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.34440380
7Propanoate metabolism_Homo sapiens_hsa006402.98497628
8Basal transcription factors_Homo sapiens_hsa030222.93105635
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86810433
10Linoleic acid metabolism_Homo sapiens_hsa005912.81623353
11Glucagon signaling pathway_Homo sapiens_hsa049222.73801027
12Pentose phosphate pathway_Homo sapiens_hsa000302.63893081
13Phototransduction_Homo sapiens_hsa047442.55776898
14Nitrogen metabolism_Homo sapiens_hsa009102.44941526
15Fanconi anemia pathway_Homo sapiens_hsa034602.31740472
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31427449
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.17929073
18One carbon pool by folate_Homo sapiens_hsa006702.16528969
19Oocyte meiosis_Homo sapiens_hsa041142.07312632
20Selenocompound metabolism_Homo sapiens_hsa004501.99794476
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99691057
22Glycerolipid metabolism_Homo sapiens_hsa005611.91799159
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89949911
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85831340
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.85260602
26Rheumatoid arthritis_Homo sapiens_hsa053231.84483993
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.82432136
28TGF-beta signaling pathway_Homo sapiens_hsa043501.81660601
29Dorso-ventral axis formation_Homo sapiens_hsa043201.79776847
30Autoimmune thyroid disease_Homo sapiens_hsa053201.76926495
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71613436
32PPAR signaling pathway_Homo sapiens_hsa033201.66362967
33Allograft rejection_Homo sapiens_hsa053301.65900542
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63704050
35Graft-versus-host disease_Homo sapiens_hsa053321.59613603
36Amphetamine addiction_Homo sapiens_hsa050311.58918906
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.56685156
38Other glycan degradation_Homo sapiens_hsa005111.54858122
39Huntingtons disease_Homo sapiens_hsa050161.53083461
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50503330
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.47982858
42Carbon metabolism_Homo sapiens_hsa012001.44222854
43Hippo signaling pathway_Homo sapiens_hsa043901.43140684
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.41002278
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39588731
46Morphine addiction_Homo sapiens_hsa050321.37542988
47Type I diabetes mellitus_Homo sapiens_hsa049401.34406626
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34028275
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.32905458
50Ether lipid metabolism_Homo sapiens_hsa005651.32674285
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32101105
52mRNA surveillance pathway_Homo sapiens_hsa030151.31795652
53RNA transport_Homo sapiens_hsa030131.28694812
54Sulfur relay system_Homo sapiens_hsa041221.28424271
55Fructose and mannose metabolism_Homo sapiens_hsa000511.26304960
56Rap1 signaling pathway_Homo sapiens_hsa040151.25808899
57Fat digestion and absorption_Homo sapiens_hsa049751.23965704
58Cardiac muscle contraction_Homo sapiens_hsa042601.22294036
59Mineral absorption_Homo sapiens_hsa049781.21770846
60Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21034952
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18485241
62Purine metabolism_Homo sapiens_hsa002301.17235921
63Renin secretion_Homo sapiens_hsa049241.14222915
64Serotonergic synapse_Homo sapiens_hsa047261.11151485
65beta-Alanine metabolism_Homo sapiens_hsa004101.08918481
66Biosynthesis of amino acids_Homo sapiens_hsa012301.07713888
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04928368
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03706278
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00399458
70Fatty acid degradation_Homo sapiens_hsa000710.99905244
71Fatty acid metabolism_Homo sapiens_hsa012120.99527078
72Butanoate metabolism_Homo sapiens_hsa006500.99464632
73Antigen processing and presentation_Homo sapiens_hsa046120.97140742
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95538936
75Ovarian steroidogenesis_Homo sapiens_hsa049130.91595393
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.91500608
77Viral myocarditis_Homo sapiens_hsa054160.84420881
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83021910
79Olfactory transduction_Homo sapiens_hsa047400.82460918
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78722575
81Glutathione metabolism_Homo sapiens_hsa004800.77986634
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.77460283
83Glutamatergic synapse_Homo sapiens_hsa047240.77173929
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75763882
85Renin-angiotensin system_Homo sapiens_hsa046140.75687465
86Arachidonic acid metabolism_Homo sapiens_hsa005900.75161146
87Long-term potentiation_Homo sapiens_hsa047200.73390351
88Asthma_Homo sapiens_hsa053100.70726829
89Collecting duct acid secretion_Homo sapiens_hsa049660.66163386
90Nicotine addiction_Homo sapiens_hsa050330.63993222
91Insulin secretion_Homo sapiens_hsa049110.63552178
92Estrogen signaling pathway_Homo sapiens_hsa049150.62911275
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62306510
94Ras signaling pathway_Homo sapiens_hsa040140.61708789
95Chemical carcinogenesis_Homo sapiens_hsa052040.61515883
96Hedgehog signaling pathway_Homo sapiens_hsa043400.60473425
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.59869735
98Thyroid hormone synthesis_Homo sapiens_hsa049180.58816977
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58101122
100ABC transporters_Homo sapiens_hsa020100.57480549
101Oxytocin signaling pathway_Homo sapiens_hsa049210.56173187
102Calcium signaling pathway_Homo sapiens_hsa040200.55884433
103Vitamin digestion and absorption_Homo sapiens_hsa049770.53852015
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53808400
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53758574
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.50431424
107Systemic lupus erythematosus_Homo sapiens_hsa053220.49013691
108Long-term depression_Homo sapiens_hsa047300.48998950
109Inositol phosphate metabolism_Homo sapiens_hsa005620.46422707
110AMPK signaling pathway_Homo sapiens_hsa041520.45870639
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45843380
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45560663
113Cell cycle_Homo sapiens_hsa041100.45270756
114Bile secretion_Homo sapiens_hsa049760.44515676
115Taste transduction_Homo sapiens_hsa047420.43688204
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43511849
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42222698
118Legionellosis_Homo sapiens_hsa051340.41283886
119MAPK signaling pathway_Homo sapiens_hsa040100.40070370
120Tight junction_Homo sapiens_hsa045300.39917879
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.39864553
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39829012
123Metabolic pathways_Homo sapiens_hsa011000.39338271
124Histidine metabolism_Homo sapiens_hsa003400.38672322
125Endocytosis_Homo sapiens_hsa041440.38583060
126Pancreatic secretion_Homo sapiens_hsa049720.38336197
127Pyrimidine metabolism_Homo sapiens_hsa002400.37121133
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35725180
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35306156
130Tryptophan metabolism_Homo sapiens_hsa003800.34906401
131RNA degradation_Homo sapiens_hsa030180.34736133
132Circadian rhythm_Homo sapiens_hsa047100.34420564
133Homologous recombination_Homo sapiens_hsa034400.33906265
134Protein digestion and absorption_Homo sapiens_hsa049740.33131938
135GABAergic synapse_Homo sapiens_hsa047270.32158863
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31209860
137VEGF signaling pathway_Homo sapiens_hsa043700.31143459
138Synaptic vesicle cycle_Homo sapiens_hsa047210.30676842
139Tuberculosis_Homo sapiens_hsa051520.30102275
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30098602
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29983044
142Gastric acid secretion_Homo sapiens_hsa049710.27391342
143Salivary secretion_Homo sapiens_hsa049700.27246270
144cAMP signaling pathway_Homo sapiens_hsa040240.26850397
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26006755
146N-Glycan biosynthesis_Homo sapiens_hsa005100.24141498
147Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24091733
148Sulfur metabolism_Homo sapiens_hsa009200.21587395
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20036290
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20000315
151Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19600016
152Cocaine addiction_Homo sapiens_hsa050300.18986829
153Circadian entrainment_Homo sapiens_hsa047130.18373547
154Wnt signaling pathway_Homo sapiens_hsa043100.18353090
155Alcoholism_Homo sapiens_hsa050340.16712248
156Viral carcinogenesis_Homo sapiens_hsa052030.16673294
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15387497
158Retinol metabolism_Homo sapiens_hsa008300.09291090
159B cell receptor signaling pathway_Homo sapiens_hsa046620.07941786

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