ZSCAN5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)7.87476668
2vitamin transmembrane transport (GO:0035461)6.43706994
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.33662682
4purine nucleobase biosynthetic process (GO:0009113)6.20367338
5regulation of spindle organization (GO:0090224)6.11548292
6metaphase plate congression (GO:0051310)5.97957949
7monoubiquitinated protein deubiquitination (GO:0035520)5.42999320
8DNA replication checkpoint (GO:0000076)5.40249855
9regulation of acrosome reaction (GO:0060046)5.24710708
10nucleobase biosynthetic process (GO:0046112)5.18744237
11regulation of exit from mitosis (GO:0007096)5.00235439
12regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.87035624
13ribosome biogenesis (GO:0042254)4.81472273
14regulation of mitotic spindle organization (GO:0060236)4.74961119
15ribosome assembly (GO:0042255)4.66307302
16protein localization to kinetochore (GO:0034501)4.65869424
17positive regulation of chromosome segregation (GO:0051984)4.62163711
18establishment of chromosome localization (GO:0051303)4.59208552
19positive regulation of uterine smooth muscle contraction (GO:0070474)4.53795258
20meiosis I (GO:0007127)4.53369423
21folic acid metabolic process (GO:0046655)4.43507998
22multicellular organism reproduction (GO:0032504)4.41671964
23protein localization to chromosome, centromeric region (GO:0071459)4.41331439
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.38477079
25termination of RNA polymerase III transcription (GO:0006386)4.38477079
26positive regulation of protein homooligomerization (GO:0032464)4.35094043
27termination of RNA polymerase I transcription (GO:0006363)4.34493186
287-methylguanosine mRNA capping (GO:0006370)4.34190621
297-methylguanosine RNA capping (GO:0009452)4.31513591
30RNA capping (GO:0036260)4.31513591
31regulation of female gonad development (GO:2000194)4.29188496
32male meiosis I (GO:0007141)4.27129247
33protein K6-linked ubiquitination (GO:0085020)4.25158600
34maturation of 5.8S rRNA (GO:0000460)4.24884642
35negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.17563365
36transcription elongation from RNA polymerase I promoter (GO:0006362)4.15956074
37rRNA modification (GO:0000154)4.14522581
38maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.13784588
39microtubule depolymerization (GO:0007019)4.11805536
40oocyte maturation (GO:0001556)4.06393819
41transcription from RNA polymerase I promoter (GO:0006360)4.06181828
42regulation of chromosome segregation (GO:0051983)4.04421766
43inner cell mass cell proliferation (GO:0001833)4.04312849
44spindle checkpoint (GO:0031577)4.02231528
45synaptonemal complex assembly (GO:0007130)4.01283813
46regulation of retinoic acid receptor signaling pathway (GO:0048385)34.5973258
47negative regulation of fibroblast apoptotic process (GO:2000270)3.99531074
48regulation of establishment of cell polarity (GO:2000114)3.98608325
49regulation of cytokine production involved in inflammatory response (GO:1900015)3.98512929
50regulation of meiosis I (GO:0060631)3.98462683
51transcription elongation from RNA polymerase II promoter (GO:0006368)3.93967036
52regulation of transcription from RNA polymerase I promoter (GO:0006356)3.93269130
53transcription initiation from RNA polymerase I promoter (GO:0006361)3.88499785
54regulation of RNA export from nucleus (GO:0046831)3.86688307
55DNA-templated transcription, elongation (GO:0006354)3.84205928
56snRNA transcription (GO:0009301)3.81616541
57protein localization to chromosome (GO:0034502)3.75948858
58mitotic sister chromatid segregation (GO:0000070)3.75514752
59regulation of double-strand break repair via homologous recombination (GO:0010569)3.70134746
60blastocyst development (GO:0001824)3.68782472
61lung-associated mesenchyme development (GO:0060484)3.67885053
62DNA damage response, signal transduction resulting in transcription (GO:0042772)3.64360904
63synaptonemal complex organization (GO:0070193)3.62460329
64regulation of female receptivity (GO:0045924)3.62095680
65folic acid transport (GO:0015884)3.61750270
66attachment of spindle microtubules to kinetochore (GO:0008608)3.61608340
67histone H2A monoubiquitination (GO:0035518)3.58569250
68transcription from mitochondrial promoter (GO:0006390)3.57294771
69male meiosis (GO:0007140)3.56188290
70mitotic nuclear envelope disassembly (GO:0007077)3.54862805
71aggressive behavior (GO:0002118)3.53935210
72mitotic spindle checkpoint (GO:0071174)3.53517405
73mitotic chromosome condensation (GO:0007076)3.52148163
74histone exchange (GO:0043486)3.50860449
75rRNA methylation (GO:0031167)3.48290804
76regulation of uterine smooth muscle contraction (GO:0070472)3.48089340
77CENP-A containing nucleosome assembly (GO:0034080)3.44953882
78regulation of establishment or maintenance of cell polarity (GO:0032878)3.41342178
79drinking behavior (GO:0042756)3.41299835
80protein kinase C signaling (GO:0070528)3.39507182
81positive regulation of viral transcription (GO:0050434)3.38901949
82positive regulation of humoral immune response (GO:0002922)3.37574314
83negative regulation of DNA-dependent DNA replication (GO:2000104)3.36747866
84hyperosmotic salinity response (GO:0042538)3.36351323
85negative regulation of chromosome segregation (GO:0051985)3.34898833
86regulation of mitotic metaphase/anaphase transition (GO:0030071)3.34811186
87positive regulation of mitotic sister chromatid separation (GO:1901970)3.34643098
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.34643098
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.34643098
90chromosome segregation (GO:0007059)3.32412341
91membrane disassembly (GO:0030397)3.30715910
92nuclear envelope disassembly (GO:0051081)3.30715910
93DNA replication-independent nucleosome assembly (GO:0006336)3.29271338
94DNA replication-independent nucleosome organization (GO:0034724)3.29271338
95kinetochore assembly (GO:0051382)3.28901951
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28167424
97negative regulation of sister chromatid segregation (GO:0033046)3.28126510
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.28126510
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28126510
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28126510
101meiotic chromosome segregation (GO:0045132)3.27528793
102DNA-dependent DNA replication (GO:0006261)3.27081803
103regulation of penile erection (GO:0060405)3.25350308
104DNA synthesis involved in DNA repair (GO:0000731)3.24358484
105mitotic spindle assembly checkpoint (GO:0007094)3.23111802
106regulation of DNA methylation (GO:0044030)3.22635614
107chromatin remodeling at centromere (GO:0031055)3.21975808
108resolution of meiotic recombination intermediates (GO:0000712)3.21435806
109meiotic cell cycle process (GO:1903046)3.20601631
110reciprocal DNA recombination (GO:0035825)3.20528192
111reciprocal meiotic recombination (GO:0007131)3.20528192
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19725309
113spindle assembly checkpoint (GO:0071173)3.18531935
114positive regulation of prostaglandin secretion (GO:0032308)3.16403719
115nuclear pore organization (GO:0006999)3.15151254
116transcription from RNA polymerase III promoter (GO:0006383)3.14962704
117histone H2A ubiquitination (GO:0033522)3.14380885
118regulation of mitotic sister chromatid segregation (GO:0033047)3.12962271
119oocyte development (GO:0048599)3.11346445
120female mating behavior (GO:0060180)3.11070842
121positive regulation of catecholamine secretion (GO:0033605)3.09129206
122autophagic vacuole assembly (GO:0000045)3.08744920
123negative regulation of reproductive process (GO:2000242)3.07471399
124maturation of SSU-rRNA (GO:0030490)3.03983893
125response to acidic pH (GO:0010447)3.03956132
126glycine transport (GO:0015816)3.00018841
127sleep (GO:0030431)2.97700490
128reproduction (GO:0000003)2.97022976
129binding of sperm to zona pellucida (GO:0007339)2.89486512
130ventricular cardiac muscle cell development (GO:0055015)2.89463671
131positive regulation of digestive system process (GO:0060456)2.89185422
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79304153
133cellular response to pH (GO:0071467)2.73546069
134negative regulation of digestive system process (GO:0060457)2.73500311
135chaperone-mediated protein transport (GO:0072321)2.70628535
136meiotic cell cycle (GO:0051321)2.66388990
137regulation of prostaglandin secretion (GO:0032306)2.66073317
138meiotic nuclear division (GO:0007126)2.60809292
139N-terminal protein amino acid acetylation (GO:0006474)2.59990549
140piRNA metabolic process (GO:0034587)2.54559146
141chaperone mediated protein folding requiring cofactor (GO:0051085)2.50898078
142telomere maintenance via telomere lengthening (GO:0010833)2.45173723
143regulation of G0 to G1 transition (GO:0070316)2.44428812
144positive regulation of reproductive process (GO:2000243)2.43660248
145histone H3-K9 demethylation (GO:0033169)2.37547246
146chromosome condensation (GO:0030261)2.30422258
147regulation of norepinephrine secretion (GO:0014061)2.30395895
148maternal behavior (GO:0042711)2.29815963
149regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.26677444
150regulation of protein homooligomerization (GO:0032462)2.24460425
151sperm-egg recognition (GO:0035036)2.22753810
152single fertilization (GO:0007338)2.17699997
153skeletal muscle tissue regeneration (GO:0043403)2.14760849
154regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.11008844
155positive regulation of protein oligomerization (GO:0032461)2.10780270
156polyamine biosynthetic process (GO:0006596)2.10148782
157L-amino acid import (GO:0043092)2.07592440
158positive regulation of cAMP-mediated signaling (GO:0043950)2.03199190
159rRNA processing (GO:0006364)2.03069778
160parental behavior (GO:0060746)2.00242527
161regulation of histone H3-K9 methylation (GO:0051570)1.99438110
162mitochondrial RNA metabolic process (GO:0000959)1.99409486
163DNA packaging (GO:0006323)1.96688940
164negative regulation of RNA splicing (GO:0033119)1.95516026
165sensory perception of taste (GO:0050909)1.95239677
166response to food (GO:0032094)1.93991737
167fertilization (GO:0009566)1.93528029
168DNA replication initiation (GO:0006270)1.93290324
169rRNA metabolic process (GO:0016072)1.93269998
170ribosomal small subunit biogenesis (GO:0042274)1.92976583
171ribonucleoprotein complex biogenesis (GO:0022613)1.92963084
172regulation of cell cycle G2/M phase transition (GO:1902749)1.92279490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.21491029
2E2F7_22180533_ChIP-Seq_HELA_Human6.05299986
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.50202693
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.08928325
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.08928325
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.08928325
7EZH2_22144423_ChIP-Seq_EOC_Human4.56979588
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.07794545
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91013578
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.58543508
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.50613470
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.33192404
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26031845
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.22564674
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21561064
16ZNF274_21170338_ChIP-Seq_K562_Hela3.14518800
17AR_21909140_ChIP-Seq_LNCAP_Human3.14261842
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.98044731
19* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.87091877
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86023794
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.79905538
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.70569716
23ETV1_20927104_ChIP-Seq_GIST48_Human2.53485048
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51346936
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47027480
26RBPJ_21746931_ChIP-Seq_IB4_Human2.41106297
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40015724
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.25131887
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.23139482
30NFYB_21822215_ChIP-Seq_K562_Human2.19516526
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19068702
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19014456
33TBL1_22424771_ChIP-Seq_293T_Human2.15712721
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15643340
35TP63_19390658_ChIP-ChIP_HaCaT_Human2.14937649
36MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13433825
37PHF8_20622853_ChIP-Seq_HELA_Human2.11658418
38MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08878602
39VDR_23849224_ChIP-Seq_CD4+_Human2.07690281
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06046686
41SALL1_21062744_ChIP-ChIP_HESCs_Human2.00601760
42GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.98977895
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95372952
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95076396
45GATA6_21074721_ChIP-Seq_CACO-2_Human1.89353298
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.83244408
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.82552480
48XRN2_22483619_ChIP-Seq_HELA_Human1.80118452
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77640365
50GABP_19822575_ChIP-Seq_HepG2_Human1.73699478
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73324962
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68848150
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67312407
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.62838745
55ZNF263_19887448_ChIP-Seq_K562_Human1.59995338
56KDM5A_27292631_Chip-Seq_BREAST_Human1.59175032
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58104636
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49523022
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49481594
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.48861042
61FOXP3_21729870_ChIP-Seq_TREG_Human1.46989917
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43310581
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.43031118
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39391027
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36208583
66NFYA_21822215_ChIP-Seq_K562_Human1.34331300
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32510715
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.30378336
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29768383
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29696488
71DCP1A_22483619_ChIP-Seq_HELA_Human1.24827387
72PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21620770
73NANOG_20526341_ChIP-Seq_ESCs_Human1.21330420
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20347226
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17835823
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15595352
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15185217
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14603126
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13335451
80RAC3_21632823_ChIP-Seq_H3396_Human1.12018679
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11019827
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10928299
83* KAP1_27257070_Chip-Seq_ESCs_Mouse1.10152322
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08365167
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07386409
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.05087988
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04906770
88LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04495077
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03008048
90TTF2_22483619_ChIP-Seq_HELA_Human1.02249624
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02021516
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01651849
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01089315
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98772931
95E2F1_20622854_ChIP-Seq_HELA_Human0.97069859
96SRF_21415370_ChIP-Seq_HL-1_Mouse0.96954002
97CTCF_20526341_ChIP-Seq_ESCs_Human0.96868454
98IRF1_19129219_ChIP-ChIP_H3396_Human0.96110588
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94022046
100SOX2_21211035_ChIP-Seq_LN229_Human0.93506159
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92922864
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92723625
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92677624
104TP53_22573176_ChIP-Seq_HFKS_Human0.92512663
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92047260
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.91263112
107MYC_18940864_ChIP-ChIP_HL60_Human0.91212299
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91101173
109ELK1_19687146_ChIP-ChIP_HELA_Human0.90161214
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88628730
111CIITA_25753668_ChIP-Seq_RAJI_Human0.87382971
112* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86242702
113YY1_22570637_ChIP-Seq_MALME-3M_Human0.86086224
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86040157
115SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85900260
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84426977
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82627678
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82179915
119TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80933672
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80627749
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80221424
122CBX2_22325352_ChIP-Seq_293T-Rex_Human0.79552041
123CTCF_21964334_Chip-Seq_Bcells_Human0.78561200
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.78259271
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77952225
126POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77896011
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77683815
128NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76611306
129NCOR_22424771_ChIP-Seq_293T_Human0.76315149
130TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76156420
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75234451
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74543705
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73829079
134GATA1_26923725_Chip-Seq_HPCs_Mouse0.73235737
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70794467
136HOXB7_26014856_ChIP-Seq_BT474_Human0.70232983
137ETV2_25802403_ChIP-Seq_MESCs_Mouse0.69881920
138FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69214998
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69000649
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68551567
141TFEB_21752829_ChIP-Seq_HELA_Human0.67880581
142NANOG_18692474_ChIP-Seq_MESCs_Mouse0.67861733
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.67422547
144SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.67188476
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.66769443
146SOX2_18692474_ChIP-Seq_MESCs_Mouse0.65900593
147TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65686960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.39375778
2MP0001986_abnormal_taste_sensitivity6.21594191
3MP0005423_abnormal_somatic_nervous5.26037065
4MP0003111_abnormal_nucleus_morphology4.71567709
5MP0003718_maternal_effect4.33584709
6MP0003077_abnormal_cell_cycle3.83969708
7MP0009379_abnormal_foot_pigmentation3.82300481
8MP0008057_abnormal_DNA_replication3.73925817
9MP0010094_abnormal_chromosome_stability3.72610322
10MP0004957_abnormal_blastocyst_morpholog3.51841317
11MP0005451_abnormal_body_composition3.37026579
12MP0008058_abnormal_DNA_repair3.16455418
13MP0008877_abnormal_DNA_methylation3.08836425
14MP0008007_abnormal_cellular_replicative3.05334952
15MP0005394_taste/olfaction_phenotype2.92834546
16MP0005499_abnormal_olfactory_system2.92834546
17MP0010307_abnormal_tumor_latency2.75213633
18MP0002102_abnormal_ear_morphology2.74588503
19MP0003123_paternal_imprinting2.53303605
20MP0005410_abnormal_fertilization2.48907574
21MP0001730_embryonic_growth_arrest2.42140328
22MP0008260_abnormal_autophagy2.38948517
23MP0006292_abnormal_olfactory_placode2.38126733
24MP0003786_premature_aging2.36857142
25MP0008789_abnormal_olfactory_epithelium2.11129324
26MP0000350_abnormal_cell_proliferation2.01212496
27MP0008932_abnormal_embryonic_tissue1.95881947
28MP0002210_abnormal_sex_determination1.93438968
29MP0005380_embryogenesis_phenotype1.89559477
30MP0001672_abnormal_embryogenesis/_devel1.89559477
31MP0001929_abnormal_gametogenesis1.76218182
32MP0005377_hearing/vestibular/ear_phenot1.71589786
33MP0003878_abnormal_ear_physiology1.71589786
34MP0010030_abnormal_orbit_morphology1.71279214
35MP0006276_abnormal_autonomic_nervous1.70935743
36MP0005360_urolithiasis1.69682210
37MP0008995_early_reproductive_senescence1.69460723
38MP0001881_abnormal_mammary_gland1.64896221
39MP0009333_abnormal_splenocyte_physiolog1.64315876
40MP0000653_abnormal_sex_gland1.60870560
41MP0001145_abnormal_male_reproductive1.60073159
42MP0001661_extended_life_span1.56159834
43MP0002138_abnormal_hepatobiliary_system1.55068074
44MP0003984_embryonic_growth_retardation1.54415460
45MP0005395_other_phenotype1.50724228
46MP0009840_abnormal_foam_cell1.50686023
47MP0002396_abnormal_hematopoietic_system1.50555910
48MP0002088_abnormal_embryonic_growth/wei1.48598192
49MP0003221_abnormal_cardiomyocyte_apopto1.48571929
50MP0001697_abnormal_embryo_size1.47798785
51MP0003938_abnormal_ear_development1.46104834
52MP0002163_abnormal_gland_morphology1.44920044
53MP0002085_abnormal_embryonic_tissue1.40455156
54MP0003937_abnormal_limbs/digits/tail_de1.37242084
55MP0001119_abnormal_female_reproductive1.36574177
56MP0003699_abnormal_female_reproductive1.35652330
57MP0002080_prenatal_lethality1.32954694
58MP0003879_abnormal_hair_cell1.31589132
59MP0001502_abnormal_circadian_rhythm1.27064715
60MP0010368_abnormal_lymphatic_system1.25809736
61MP0002653_abnormal_ependyma_morphology1.24988878
62MP0002084_abnormal_developmental_patter1.21850332
63MP0003646_muscle_fatigue1.20511772
64MP0005646_abnormal_pituitary_gland1.13144046
65MP0002086_abnormal_extraembryonic_tissu1.13074354
66MP0005408_hypopigmentation1.13043053
67MP0005257_abnormal_intraocular_pressure1.09993625
68MP0001293_anophthalmia1.07496691
69MP0009672_abnormal_birth_weight1.07323945
70MP0001529_abnormal_vocalization1.07128891
71MP0003698_abnormal_male_reproductive1.06332878
72MP0000049_abnormal_middle_ear1.04508181
73MP0003315_abnormal_perineum_morphology1.03628149
74MP0004185_abnormal_adipocyte_glucose1.03115410
75MP0002161_abnormal_fertility/fecundity1.01336651
76MP0002132_abnormal_respiratory_system0.98511697
77MP0001545_abnormal_hematopoietic_system0.97892513
78MP0005397_hematopoietic_system_phenotyp0.97892513
79MP0003136_yellow_coat_color0.94981099
80MP0005621_abnormal_cell_physiology0.94949489
81MP0005647_abnormal_sex_gland0.93869456
82MP0000372_irregular_coat_pigmentation0.91919696
83MP0004142_abnormal_muscle_tone0.90808398
84MP0004215_abnormal_myocardial_fiber0.89124496
85MP0005310_abnormal_salivary_gland0.88460758
86MP0000313_abnormal_cell_death0.87513389
87MP0002160_abnormal_reproductive_system0.85593688
88MP0000750_abnormal_muscle_regeneration0.84131072
89MP0002233_abnormal_nose_morphology0.83999247
90MP0006036_abnormal_mitochondrial_physio0.83010206
91MP0003195_calcinosis0.81261491
92MP0002938_white_spotting0.80170699
93MP0001919_abnormal_reproductive_system0.79550163
94MP0002277_abnormal_respiratory_mucosa0.79259527
95MP0002019_abnormal_tumor_incidence0.78211785
96MP0001666_abnormal_nutrient_absorption0.77045749
97MP0002254_reproductive_system_inflammat0.77041158
98MP0003567_abnormal_fetal_cardiomyocyte0.75555401
99MP0005076_abnormal_cell_differentiation0.75299548
100MP0000627_abnormal_mammary_gland0.74907565
101MP0002234_abnormal_pharynx_morphology0.73144122
102MP0003828_pulmonary_edema0.73115365
103MP0000428_abnormal_craniofacial_morphol0.73112476
104MP0005384_cellular_phenotype0.72267943
105MP0000462_abnormal_digestive_system0.71618368
106MP0005389_reproductive_system_phenotype0.71561532
107MP0000631_abnormal_neuroendocrine_gland0.70471568
108MP0004885_abnormal_endolymph0.68818788
109MP0000647_abnormal_sebaceous_gland0.66437192
110MP0003755_abnormal_palate_morphology0.66273228
111MP0002873_normal_phenotype0.65649504
112MP0002169_no_abnormal_phenotype0.65375958
113MP0000383_abnormal_hair_follicle0.64878745
114MP0003121_genomic_imprinting0.64250446
115MP0003890_abnormal_embryonic-extraembry0.63505841
116MP0003935_abnormal_craniofacial_develop0.61597517
117MP0002139_abnormal_hepatobiliary_system0.61547444
118MP0003950_abnormal_plasma_membrane0.61499265
119MP0000579_abnormal_nail_morphology0.60949679
120MP0000762_abnormal_tongue_morphology0.60400478
121MP0009703_decreased_birth_body0.60264209
122MP0001286_abnormal_eye_development0.59918848
123MP0000358_abnormal_cell_content/0.59178771
124MP0003936_abnormal_reproductive_system0.58600737
125MP0005379_endocrine/exocrine_gland_phen0.58099809
126MP0004808_abnormal_hematopoietic_stem0.56318258
127MP0000490_abnormal_crypts_of0.55722123
128MP0004197_abnormal_fetal_growth/weight/0.55535254
129MP0004019_abnormal_vitamin_homeostasis0.54777686
130MP0001485_abnormal_pinna_reflex0.54407415
131MP0002127_abnormal_cardiovascular_syste0.52121951
132MP0000432_abnormal_head_morphology0.51651277
133MP0000678_abnormal_parathyroid_gland0.49528279
134MP0004264_abnormal_extraembryonic_tissu0.49521000
135MP0002009_preneoplasia0.49036097
136MP0003119_abnormal_digestive_system0.48965780
137MP0001849_ear_inflammation0.48608657
138MP0005197_abnormal_uvea_morphology0.48238550
139MP0002638_abnormal_pupillary_reflex0.47524748
140MP0000015_abnormal_ear_pigmentation0.46107465
141MP0004233_abnormal_muscle_weight0.44404343
142MP0002095_abnormal_skin_pigmentation0.42155129
143MP0001440_abnormal_grooming_behavior0.41904876

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.30968065
2Malnutrition (HP:0004395)5.50509475
3Breast hypoplasia (HP:0003187)5.49028610
4Aplasia/hypoplasia of the uterus (HP:0008684)4.76042156
5Impulsivity (HP:0100710)4.71341577
6Facial hemangioma (HP:0000329)4.63626757
7Hypercortisolism (HP:0001578)4.50321313
8Carpal bone hypoplasia (HP:0001498)4.37535149
9Patellar aplasia (HP:0006443)4.35777672
10Hyperglycinemia (HP:0002154)4.33349286
11Chromosomal breakage induced by crosslinking agents (HP:0003221)4.32991255
12Entropion (HP:0000621)4.26810212
13Aplasia/Hypoplasia of the patella (HP:0006498)4.25321630
14Hypoplasia of the uterus (HP:0000013)4.09426296
15Capillary hemangiomas (HP:0005306)4.01604204
16Chromsome breakage (HP:0040012)3.98004541
17Infertility (HP:0000789)3.92225231
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.77102009
19Abnormality of the labia minora (HP:0012880)3.76652792
20Gout (HP:0001997)3.73809189
21Azoospermia (HP:0000027)3.69681780
22Male infertility (HP:0003251)3.69640199
23Abnormal spermatogenesis (HP:0008669)3.69613271
24Cerebral hypomyelination (HP:0006808)3.68284598
25Patent foramen ovale (HP:0001655)3.64020650
26Rhinitis (HP:0012384)3.54808477
27Periauricular skin pits (HP:0100277)3.48082263
28Preauricular pit (HP:0004467)3.48082263
29Hyperglycinuria (HP:0003108)3.47245077
30Abnormality of the septum pellucidum (HP:0007375)3.42617935
31Aplasia/Hypoplasia of the fovea (HP:0008060)3.34871539
32Hypoplasia of the fovea (HP:0007750)3.34871539
33Rough bone trabeculation (HP:0100670)3.30919686
34Abnormality of the preputium (HP:0100587)3.29110206
35Mutism (HP:0002300)3.27763918
36Prostate neoplasm (HP:0100787)3.26730283
37Muscle stiffness (HP:0003552)3.24567086
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.24287363
39Atrioventricular block (HP:0001678)3.22161196
40Abnormal pancreas size (HP:0012094)3.21711192
41Meckel diverticulum (HP:0002245)3.21571190
42Sensory axonal neuropathy (HP:0003390)3.14982089
43Anterior segment dysgenesis (HP:0007700)3.11809631
44Breast aplasia (HP:0100783)3.06176991
45Oligodactyly (hands) (HP:0001180)3.04583889
46Double outlet right ventricle (HP:0001719)3.03055515
47Congenital malformation of the right heart (HP:0011723)3.03055515
48Hypergonadotropic hypogonadism (HP:0000815)3.02645838
49Short tibia (HP:0005736)3.02148485
50Tetraplegia (HP:0002445)3.00458243
51Abnormality of the ileum (HP:0001549)2.96081026
52Myokymia (HP:0002411)2.92739861
53Steatorrhea (HP:0002570)2.89954861
54Aplasia/Hypoplasia of the breasts (HP:0010311)2.87740908
55Flat capital femoral epiphysis (HP:0003370)2.86189918
56Hypophosphatemic rickets (HP:0004912)2.85811267
57Abnormality of chromosome stability (HP:0003220)2.85348579
58Abnormal umbilical cord blood vessels (HP:0011403)2.85173515
59Single umbilical artery (HP:0001195)2.85173515
60Abnormality of the fetal cardiovascular system (HP:0010948)2.85173515
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.83720394
62CNS hypomyelination (HP:0003429)2.81116689
63Oligodactyly (HP:0012165)2.75043906
64Oral leukoplakia (HP:0002745)2.73183535
65Absent septum pellucidum (HP:0001331)2.68589580
66Secondary amenorrhea (HP:0000869)2.65267928
67Dysphonia (HP:0001618)2.65004968
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.64265533
69Reticulocytopenia (HP:0001896)2.62627676
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.59302219
71Facial cleft (HP:0002006)2.58301403
72Abnormal trabecular bone morphology (HP:0100671)2.57766540
73Pancreatic fibrosis (HP:0100732)2.56853332
74Absent radius (HP:0003974)2.56462912
75Fused cervical vertebrae (HP:0002949)2.56391362
76Abnormality of serine family amino acid metabolism (HP:0010894)2.56161564
77Abnormality of glycine metabolism (HP:0010895)2.56161564
78Aplasia/hypoplasia of the humerus (HP:0006507)2.55581662
79Abnormality of the fovea (HP:0000493)2.55085318
80Abnormality of abdominal situs (HP:0011620)2.53158922
81Abdominal situs inversus (HP:0003363)2.53158922
82Shawl scrotum (HP:0000049)2.50227883
83Aplasia/Hypoplasia involving the musculature (HP:0001460)2.49126427
84Adrenal hypoplasia (HP:0000835)2.48773755
85Progressive muscle weakness (HP:0003323)2.48583358
86Irregular epiphyses (HP:0010582)2.48361338
87Adrenal overactivity (HP:0002717)2.47156400
88Fat malabsorption (HP:0002630)2.47095359
89Ureteral duplication (HP:0000073)2.45981835
90Constricted visual fields (HP:0001133)2.45066715
91Aplasia involving forearm bones (HP:0009822)2.43777192
92Absent forearm bone (HP:0003953)2.43777192
93Areflexia of lower limbs (HP:0002522)2.43002968
94Multiple enchondromatosis (HP:0005701)2.41742777
95Cleft eyelid (HP:0000625)2.41290756
96Abnormality of the proximal phalanges of the hand (HP:0009834)2.39140688
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.38544384
98Skin pits (HP:0100276)2.36776622
99Papillary thyroid carcinoma (HP:0002895)2.32798748
100Aplasia/Hypoplasia of the macula (HP:0008059)2.32562100
101Limb dystonia (HP:0002451)2.28708565
102Small epiphyses (HP:0010585)2.28672902
103Duodenal stenosis (HP:0100867)2.25529050
104Small intestinal stenosis (HP:0012848)2.25529050
105Sparse lateral eyebrow (HP:0005338)2.25175186
106Microglossia (HP:0000171)2.23221211
107Glossoptosis (HP:0000162)2.22562275
108Death in infancy (HP:0001522)2.21894250
109Microvesicular hepatic steatosis (HP:0001414)2.21729776
110Abnormality of the aortic arch (HP:0012303)2.20034131
111Short thumb (HP:0009778)2.19637316
112Progressive hearing impairment (HP:0001730)2.19483333
113Midline defect of the nose (HP:0004122)2.18723316
114Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18611688
115Bone marrow hypocellularity (HP:0005528)2.18400610
116Muscle fiber splitting (HP:0003555)2.15661670
117Abnormality of lateral ventricle (HP:0030047)2.15163125
118Absent thumb (HP:0009777)2.14019777
119Segmental peripheral demyelination/remyelination (HP:0003481)2.13089625
120Aplasia/Hypoplasia affecting the retina (HP:0008061)2.12701610
121Delayed CNS myelination (HP:0002188)2.12297523
122Bundle branch block (HP:0011710)2.11668992
123Horseshoe kidney (HP:0000085)2.11315128
124Pendular nystagmus (HP:0012043)2.10131960
125Septo-optic dysplasia (HP:0100842)2.08623309
126Progressive sensorineural hearing impairment (HP:0000408)2.08525867
127Acute myeloid leukemia (HP:0004808)2.07271170
128Stenosis of the external auditory canal (HP:0000402)2.07064117
129Congenital ichthyosiform erythroderma (HP:0007431)2.06087767
130Hypoglycemic seizures (HP:0002173)2.05852209
131Myelodysplasia (HP:0002863)2.04890374
132Premature ovarian failure (HP:0008209)2.03306280
133Abnormality of serum amino acid levels (HP:0003112)2.03109229
134Prominent nose (HP:0000448)2.02454540
135Heart block (HP:0012722)2.02347754
136Gonadotropin excess (HP:0000837)2.02294413
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02246021
138Absent epiphyses (HP:0010577)2.02246021
139Osteomalacia (HP:0002749)2.00829538
140Pustule (HP:0200039)2.00184743
141Pili torti (HP:0003777)1.98937193
142Anhidrosis (HP:0000970)1.94189801
143Brittle hair (HP:0002299)1.94183493
144Atresia of the external auditory canal (HP:0000413)1.94171043
145Slender long bone (HP:0003100)1.91513752
146Microretrognathia (HP:0000308)1.91141098
147Ventricular fibrillation (HP:0001663)1.90477660
148Abnormality of cells of the erythroid lineage (HP:0012130)1.90283520
149Abnormal ciliary motility (HP:0012262)1.88928142
150Pelvic girdle muscle weakness (HP:0003749)1.87608894
151Hyperuricemia (HP:0002149)1.86894240
152Increased purine levels (HP:0004368)1.86894240
153Attenuation of retinal blood vessels (HP:0007843)1.85856775
154Abnormal atrioventricular conduction (HP:0005150)1.85034421
155Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84590588
156Delusions (HP:0000746)1.83863202
157Fibular aplasia (HP:0002990)1.83713483
158Impaired proprioception (HP:0010831)1.83296233
159Poikiloderma (HP:0001029)1.83234876
160Tracheoesophageal fistula (HP:0002575)1.83032249
161Ectopic kidney (HP:0000086)1.82345565
162Abnormality of DNA repair (HP:0003254)1.81990902
163Stillbirth (HP:0003826)1.81313871
164Cortical visual impairment (HP:0100704)1.81184674
165Neoplasm of the pancreas (HP:0002894)1.79940359
166Confusion (HP:0001289)1.79320311
167Trismus (HP:0000211)1.77415712
168Esotropia (HP:0000565)1.76844186
169Testicular atrophy (HP:0000029)1.76798843
170Clubbing of toes (HP:0100760)1.76773396
171Aplasia of the musculature (HP:0100854)1.76469431
172Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75982049
173Posterior subcapsular cataract (HP:0007787)1.75957740
174Abnormality of male internal genitalia (HP:0000022)1.74860907
175Nausea (HP:0002018)1.74487023
176Supernumerary spleens (HP:0009799)1.73608468
177Overlapping toe (HP:0001845)1.72874179
178Abnormality of the duodenum (HP:0002246)1.72820402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.13566068
2LATS23.98054952
3CDK193.94652121
4WEE13.88347539
5NEK23.64114354
6BRSK23.44062237
7TRIM283.13881043
8PLK43.09593319
9STK38L3.02490470
10SRPK12.64544724
11ACVR1B2.62531044
12LATS12.55470648
13EIF2AK12.45059224
14AKT32.42992708
15MKNK22.41493643
16CDC72.31886107
17STK32.28847828
18DYRK32.27162514
19BRSK12.22270348
20PLK12.18123435
21TTK2.13575443
22PLK32.06980017
23TAOK31.83904083
24CHEK21.68822711
25EIF2AK31.60130250
26BRAF1.52128045
27AURKB1.51465141
28DYRK21.48216517
29PINK11.46123088
30MKNK11.42140845
31CDK31.36539794
32TAOK11.29349762
33RAF11.23997334
34RPS6KA41.20582997
35CCNB11.19850879
36NME21.17695711
37TLK11.16899930
38PAK61.15650416
39CDK71.14194170
40KSR21.13045809
41STK161.12633525
42AURKA1.11937198
43CHEK11.09442874
44MARK31.03568879
45GSK3A1.03230197
46NEK11.00639700
47PBK0.96671648
48MUSK0.96549338
49IRAK30.95028670
50PKN10.93068559
51NME10.92137702
52PIM20.90482917
53CDK40.89694481
54NTRK30.89240280
55VRK10.89199244
56MAP3K60.88490294
57ERBB40.86616388
58STK380.86340578
59EIF2AK20.85955747
60CDK80.82052202
61WNK10.81916480
62PRKAA10.79377205
63LRRK20.79330328
64ZAK0.76087675
65STK240.75807925
66MELK0.74289087
67PDK30.73020939
68PDK40.73020939
69TSSK60.71761349
70ATR0.71256396
71ARAF0.71011881
72PAK20.69696832
73ABL20.68800996
74CDK20.68384725
75KDR0.65843286
76PRKCI0.65004576
77MAP3K80.63924280
78ATM0.62321945
79PAK10.60344032
80AKT20.60177714
81CDK120.59359392
82CDK10.58188843
83CSNK1G10.57528014
84KSR10.56374226
85TESK20.54263624
86NEK60.54063726
87BMX0.53007126
88PDK20.49182232
89ALK0.46237178
90CSNK1G30.45601652
91FRK0.45562699
92TESK10.43639979
93CSNK1G20.42168264
94MAPK100.42076560
95EPHA40.40629780
96CLK10.40540141
97STK100.39356881
98PRKG10.39159858
99CDK11A0.36581845
100DYRK1A0.36286811
101MAP3K90.33823979
102NUAK10.33623616
103STK40.32900301
104TAOK20.32143149
105CDK90.29866029
106CSNK2A10.29835300
107RPS6KA10.29264393
108MAPK10.29172786
109MAP3K50.28253071
110CSNK1E0.26871497
111WNK30.25479456
112PRKAA20.24745139
113PIM10.24446633
114PRKACB0.23746283
115PRKD10.23390502
116CSNK1A1L0.23289617
117RPS6KB10.22380507
118TYRO30.22258557
119CSNK2A20.22218466
120MAPK110.21858021
121BRD40.19763763
122GSK3B0.18811697
123PRKD20.18444746
124CSNK1A10.18076463
125CSNK1D0.17726624
126MAPK140.15185840
127TBK10.13941628
128MAPKAPK20.13094457
129CDK140.11886229
130BMPR1B0.11811887
131RPS6KA50.11416637
132MTOR0.11176474
133PRKACA0.11170973
134PAK30.09965500
135SGK20.09217261
136STK110.07966745

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.12418944
2RNA polymerase_Homo sapiens_hsa030205.63754737
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.86098319
4Ribosome_Homo sapiens_hsa030103.71096635
5Basal transcription factors_Homo sapiens_hsa030223.45621881
6Cell cycle_Homo sapiens_hsa041103.44372037
7RNA transport_Homo sapiens_hsa030133.31503860
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.16811780
9Pyrimidine metabolism_Homo sapiens_hsa002402.37103275
10Homologous recombination_Homo sapiens_hsa034402.32491131
11Fanconi anemia pathway_Homo sapiens_hsa034602.21600911
12p53 signaling pathway_Homo sapiens_hsa041152.15982968
13Taste transduction_Homo sapiens_hsa047422.15798739
14Spliceosome_Homo sapiens_hsa030402.00900666
15Pentose phosphate pathway_Homo sapiens_hsa000301.91174878
16DNA replication_Homo sapiens_hsa030301.90574720
17Nucleotide excision repair_Homo sapiens_hsa034201.87826772
18Oocyte meiosis_Homo sapiens_hsa041141.81640478
19Regulation of autophagy_Homo sapiens_hsa041401.78748694
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.77548343
21Vitamin digestion and absorption_Homo sapiens_hsa049771.77116320
22Purine metabolism_Homo sapiens_hsa002301.75166458
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69889027
24Folate biosynthesis_Homo sapiens_hsa007901.67167990
25mRNA surveillance pathway_Homo sapiens_hsa030151.66688706
26RNA degradation_Homo sapiens_hsa030181.58907414
27Mismatch repair_Homo sapiens_hsa034301.53685937
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.50124764
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42490613
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40641241
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29015943
32Circadian rhythm_Homo sapiens_hsa047101.25957284
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17447177
34Proteasome_Homo sapiens_hsa030501.17410585
35Base excision repair_Homo sapiens_hsa034101.15838279
36Biosynthesis of amino acids_Homo sapiens_hsa012301.11134895
37Epstein-Barr virus infection_Homo sapiens_hsa051691.09643770
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.07543718
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05692477
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05203496
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.04286510
42Fatty acid biosynthesis_Homo sapiens_hsa000611.02141057
43Huntingtons disease_Homo sapiens_hsa050160.97384347
44Sulfur metabolism_Homo sapiens_hsa009200.96340934
45Sulfur relay system_Homo sapiens_hsa041220.88734038
46Cardiac muscle contraction_Homo sapiens_hsa042600.84419495
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84072639
48Olfactory transduction_Homo sapiens_hsa047400.76711536
49Fatty acid elongation_Homo sapiens_hsa000620.72555268
50Herpes simplex infection_Homo sapiens_hsa051680.70065229
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68994184
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67175199
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67162310
54MicroRNAs in cancer_Homo sapiens_hsa052060.64732110
55Wnt signaling pathway_Homo sapiens_hsa043100.63892959
56FoxO signaling pathway_Homo sapiens_hsa040680.62219528
57Caffeine metabolism_Homo sapiens_hsa002320.58599439
58Non-homologous end-joining_Homo sapiens_hsa034500.58032836
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56462126
60Linoleic acid metabolism_Homo sapiens_hsa005910.56372830
61Renal cell carcinoma_Homo sapiens_hsa052110.55787876
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55685896
63TGF-beta signaling pathway_Homo sapiens_hsa043500.55567116
64Parkinsons disease_Homo sapiens_hsa050120.54450559
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.53241710
66Arginine and proline metabolism_Homo sapiens_hsa003300.51096300
67One carbon pool by folate_Homo sapiens_hsa006700.48890142
68mTOR signaling pathway_Homo sapiens_hsa041500.48613521
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48272617
70Protein export_Homo sapiens_hsa030600.44051520
71Thyroid cancer_Homo sapiens_hsa052160.43750590
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43110797
73Serotonergic synapse_Homo sapiens_hsa047260.42778754
74Inositol phosphate metabolism_Homo sapiens_hsa005620.42723755
75Small cell lung cancer_Homo sapiens_hsa052220.42342731
76Sphingolipid metabolism_Homo sapiens_hsa006000.42075084
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42067025
78Ether lipid metabolism_Homo sapiens_hsa005650.38358632
79Systemic lupus erythematosus_Homo sapiens_hsa053220.37163987
80ABC transporters_Homo sapiens_hsa020100.36209529
81Choline metabolism in cancer_Homo sapiens_hsa052310.36188521
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.34515743
83Insulin secretion_Homo sapiens_hsa049110.33007596
84Viral carcinogenesis_Homo sapiens_hsa052030.31991331
85Nicotine addiction_Homo sapiens_hsa050330.29557878
86Glycerolipid metabolism_Homo sapiens_hsa005610.27001829
87Metabolic pathways_Homo sapiens_hsa011000.26614761
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26140566
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26110148
90Hippo signaling pathway_Homo sapiens_hsa043900.25751986
91Prostate cancer_Homo sapiens_hsa052150.25223214
92Legionellosis_Homo sapiens_hsa051340.24980383
93Steroid biosynthesis_Homo sapiens_hsa001000.24689996
94Alcoholism_Homo sapiens_hsa050340.23537442
95Arachidonic acid metabolism_Homo sapiens_hsa005900.22828999
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22741055
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21576391
98Prolactin signaling pathway_Homo sapiens_hsa049170.21241969
99Protein digestion and absorption_Homo sapiens_hsa049740.21022727
100GABAergic synapse_Homo sapiens_hsa047270.19007875
101Acute myeloid leukemia_Homo sapiens_hsa052210.18908948
102Gap junction_Homo sapiens_hsa045400.17756757
103Hepatitis B_Homo sapiens_hsa051610.17416384
104HTLV-I infection_Homo sapiens_hsa051660.17171476
105Butanoate metabolism_Homo sapiens_hsa006500.16784238
106Mineral absorption_Homo sapiens_hsa049780.15893672
107Selenocompound metabolism_Homo sapiens_hsa004500.15874354
108Apoptosis_Homo sapiens_hsa042100.15565490
109Pancreatic cancer_Homo sapiens_hsa052120.15347651
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15211256
111Ovarian steroidogenesis_Homo sapiens_hsa049130.15138622
112Influenza A_Homo sapiens_hsa051640.14612222
113Arginine biosynthesis_Homo sapiens_hsa002200.12899772
114Endometrial cancer_Homo sapiens_hsa052130.11139642
115Bile secretion_Homo sapiens_hsa049760.11119334
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.10548345
117Morphine addiction_Homo sapiens_hsa050320.10452791
118AMPK signaling pathway_Homo sapiens_hsa041520.09530065
119Dorso-ventral axis formation_Homo sapiens_hsa043200.08926238
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08862945
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08401427
122Colorectal cancer_Homo sapiens_hsa052100.08228209
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07972044
124Carbon metabolism_Homo sapiens_hsa012000.07155479
125Glutathione metabolism_Homo sapiens_hsa004800.06734360
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.05992901
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.04239109
128Antigen processing and presentation_Homo sapiens_hsa046120.03253083
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.02691916
130HIF-1 signaling pathway_Homo sapiens_hsa040660.02113186
131Melanoma_Homo sapiens_hsa052180.01764870
132Amphetamine addiction_Homo sapiens_hsa050310.01495789
133Adherens junction_Homo sapiens_hsa045200.01318982
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.00196419
135Fc epsilon RI signaling pathway_Homo sapiens_hsa04664-0.0359141
136Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0287927
137Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0213977
138Tight junction_Homo sapiens_hsa04530-0.0177117
139Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0130377
140Pathways in cancer_Homo sapiens_hsa05200-0.0098874
141Shigellosis_Homo sapiens_hsa05131-0.0087815
142PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0070204
143MAPK signaling pathway_Homo sapiens_hsa04010-0.0060542

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