ZSCAN5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.22220422
2DNA deamination (GO:0045006)4.37123943
3piRNA metabolic process (GO:0034587)4.07025356
4indolalkylamine metabolic process (GO:0006586)4.02128193
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.98346295
6mitochondrial respiratory chain complex I assembly (GO:0032981)3.90971683
7NADH dehydrogenase complex assembly (GO:0010257)3.90971683
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90971683
9tryptophan catabolic process (GO:0006569)3.90890446
10indole-containing compound catabolic process (GO:0042436)3.90890446
11indolalkylamine catabolic process (GO:0046218)3.90890446
12water-soluble vitamin biosynthetic process (GO:0042364)3.72199885
13kynurenine metabolic process (GO:0070189)3.69047753
14fucose catabolic process (GO:0019317)3.59247320
15L-fucose metabolic process (GO:0042354)3.59247320
16L-fucose catabolic process (GO:0042355)3.59247320
17DNA methylation involved in gamete generation (GO:0043046)3.57409788
18regulation of cilium movement (GO:0003352)3.56896594
19cellular ketone body metabolic process (GO:0046950)3.56440756
20protein complex biogenesis (GO:0070271)3.55018461
21epithelial cilium movement (GO:0003351)3.54814101
22tryptophan metabolic process (GO:0006568)3.51153480
23protein-cofactor linkage (GO:0018065)3.48151521
24mitochondrial respiratory chain complex assembly (GO:0033108)3.41363453
25protein polyglutamylation (GO:0018095)3.35322008
26platelet dense granule organization (GO:0060155)3.33768993
27multicellular organism reproduction (GO:0032504)3.27823526
28preassembly of GPI anchor in ER membrane (GO:0016254)3.21098858
29response to pheromone (GO:0019236)3.16301531
30cilium or flagellum-dependent cell motility (GO:0001539)3.15429846
31ketone body metabolic process (GO:1902224)3.13363420
32detection of light stimulus involved in visual perception (GO:0050908)3.11574619
33detection of light stimulus involved in sensory perception (GO:0050962)3.11574619
34mannosylation (GO:0097502)3.10058363
35axoneme assembly (GO:0035082)3.08753196
36sperm motility (GO:0030317)3.06653824
37axonemal dynein complex assembly (GO:0070286)3.04394191
38cilium movement (GO:0003341)3.04149118
39synapsis (GO:0007129)3.03348104
40amine catabolic process (GO:0009310)3.02966206
41cellular biogenic amine catabolic process (GO:0042402)3.02966206
42positive regulation of oligodendrocyte differentiation (GO:0048714)2.98282051
43respiratory chain complex IV assembly (GO:0008535)2.92433814
44indole-containing compound metabolic process (GO:0042430)2.92408702
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91912040
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89136902
47energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88688060
48ATP synthesis coupled proton transport (GO:0015986)2.88688060
49nonmotile primary cilium assembly (GO:0035058)2.86530184
50male meiosis (GO:0007140)2.83818218
51negative regulation of telomere maintenance (GO:0032205)2.83811934
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83357117
53sulfation (GO:0051923)2.78506490
54negative regulation of mast cell activation (GO:0033004)2.78300197
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75940218
56ubiquinone biosynthetic process (GO:0006744)2.75833948
57base-excision repair, AP site formation (GO:0006285)2.75219244
58male meiosis I (GO:0007141)2.73782228
59somite development (GO:0061053)2.72483741
60regulation of microtubule-based movement (GO:0060632)2.71349528
61rRNA catabolic process (GO:0016075)2.68780040
62cilium morphogenesis (GO:0060271)2.67321697
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67203248
64pseudouridine synthesis (GO:0001522)2.64598537
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63979323
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63979323
67termination of RNA polymerase III transcription (GO:0006386)2.63183530
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.63183530
69protein import into peroxisome matrix (GO:0016558)2.62785465
70regulation of action potential (GO:0098900)2.62662391
71neuronal action potential (GO:0019228)2.61421633
72reciprocal DNA recombination (GO:0035825)2.59596329
73reciprocal meiotic recombination (GO:0007131)2.59596329
74cytochrome complex assembly (GO:0017004)2.57092666
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57046344
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56757335
77positive regulation of fatty acid transport (GO:2000193)2.55000919
78gamma-aminobutyric acid transport (GO:0015812)2.54565037
79tRNA processing (GO:0008033)2.53795675
80ubiquinone metabolic process (GO:0006743)2.53779199
81photoreceptor cell development (GO:0042461)2.53199726
82L-methionine biosynthetic process (GO:0071265)2.52311748
83amino acid salvage (GO:0043102)2.52311748
84L-methionine salvage (GO:0071267)2.52311748
85regulation of nuclear cell cycle DNA replication (GO:0033262)2.52276254
86negative regulation of systemic arterial blood pressure (GO:0003085)2.49611322
87peptidyl-histidine modification (GO:0018202)2.48321588
88neural tube formation (GO:0001841)2.47761647
89positive regulation of prostaglandin secretion (GO:0032308)2.47706193
90GPI anchor metabolic process (GO:0006505)2.45303264
91kidney morphogenesis (GO:0060993)2.45077630
92photoreceptor cell maintenance (GO:0045494)2.44771448
93intracellular protein transmembrane import (GO:0044743)2.44538479
94mitochondrion morphogenesis (GO:0070584)2.44268767
95recombinational repair (GO:0000725)2.43385427
96retinal cone cell development (GO:0046549)2.42663691
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.41840633
98cilium organization (GO:0044782)2.41385030
99double-strand break repair via homologous recombination (GO:0000724)2.41102813
100acrosome reaction (GO:0007340)2.40841248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela4.14568126
2EZH2_22144423_ChIP-Seq_EOC_Human3.51844425
3VDR_22108803_ChIP-Seq_LS180_Human3.48640890
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78338524
5GBX2_23144817_ChIP-Seq_PC3_Human2.71212785
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49257501
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47842677
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43884540
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30088047
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.29209293
11IGF1R_20145208_ChIP-Seq_DFB_Human2.22528799
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.17489794
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13246470
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02681611
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00882278
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00316985
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.98450642
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95063812
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94246376
20ER_23166858_ChIP-Seq_MCF-7_Human1.90516671
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90142260
22* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88341899
23TAF15_26573619_Chip-Seq_HEK293_Human1.87599986
24FUS_26573619_Chip-Seq_HEK293_Human1.85119984
25EWS_26573619_Chip-Seq_HEK293_Human1.81769804
26IRF1_19129219_ChIP-ChIP_H3396_Human1.72874533
27P300_19829295_ChIP-Seq_ESCs_Human1.72549588
28MYC_18940864_ChIP-ChIP_HL60_Human1.72322564
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70774919
30TP53_22573176_ChIP-Seq_HFKS_Human1.66755650
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.58875810
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53526335
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52282123
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.49637896
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45468280
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42902815
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42902815
38CBP_20019798_ChIP-Seq_JUKART_Human1.41471778
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41471778
40AR_21572438_ChIP-Seq_LNCaP_Human1.41065204
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40071578
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39515392
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.34897148
44VDR_23849224_ChIP-Seq_CD4+_Human1.34097801
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.33859016
46AR_25329375_ChIP-Seq_VCAP_Human1.32627908
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.31349578
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31349578
49NCOR_22424771_ChIP-Seq_293T_Human1.29588231
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27896629
51STAT3_23295773_ChIP-Seq_U87_Human1.27128084
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25883825
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25702923
54REST_21632747_ChIP-Seq_MESCs_Mouse1.25156281
55* BCAT_22108803_ChIP-Seq_LS180_Human1.24772445
56SOX2_19829295_ChIP-Seq_ESCs_Human1.24176529
57NANOG_19829295_ChIP-Seq_ESCs_Human1.24176529
58SMAD4_21799915_ChIP-Seq_A2780_Human1.20910287
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20104247
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19289751
61TCF4_23295773_ChIP-Seq_U87_Human1.19058032
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.18067486
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17558399
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16738005
65RNF2_27304074_Chip-Seq_NSC_Mouse1.16608372
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15740074
67HOXB7_26014856_ChIP-Seq_BT474_Human1.15191820
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14961653
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13879772
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13575488
71ERA_21632823_ChIP-Seq_H3396_Human1.13552973
72AR_20517297_ChIP-Seq_VCAP_Human1.13303106
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12361467
74ELK1_19687146_ChIP-ChIP_HELA_Human1.12054714
75TCF4_22108803_ChIP-Seq_LS180_Human1.10647719
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10149794
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09945064
78MYC_19829295_ChIP-Seq_ESCs_Human1.09140215
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.07783666
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07636834
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.07457012
82RUNX2_22187159_ChIP-Seq_PCA_Human1.06730861
83* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05660253
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05482628
85NANOG_20526341_ChIP-Seq_ESCs_Human1.04629702
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03479221
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02178883
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01782978
89ETV1_20927104_ChIP-Seq_GIST48_Human0.98904641
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.97671834
91TAF2_19829295_ChIP-Seq_ESCs_Human0.95618040
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95496856
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95151417
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.94472376
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.93429119
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91828334
97RBPJ_21746931_ChIP-Seq_IB4_Human0.90627729
98PHF8_20622853_ChIP-Seq_HELA_Human0.90034995
99OCT4_20526341_ChIP-Seq_ESCs_Human0.89024772
100FOXP3_21729870_ChIP-Seq_TREG_Human0.87829842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.00868738
2MP0002837_dystrophic_cardiac_calcinosis2.92178793
3MP0003195_calcinosis2.70525949
4MP0002102_abnormal_ear_morphology2.50338136
5MP0003646_muscle_fatigue2.40276410
6MP0005551_abnormal_eye_electrophysiolog2.29392909
7MP0000569_abnormal_digit_pigmentation2.23212044
8MP0001968_abnormal_touch/_nociception2.21774098
9MP0003011_delayed_dark_adaptation2.20373292
10MP0005410_abnormal_fertilization2.20354619
11MP0005646_abnormal_pituitary_gland2.13945940
12MP0006072_abnormal_retinal_apoptosis2.00649066
13MP0002638_abnormal_pupillary_reflex1.98356967
14MP0001986_abnormal_taste_sensitivity1.98042659
15MP0006292_abnormal_olfactory_placode1.95125518
16MP0008872_abnormal_physiological_respon1.90222436
17MP0009046_muscle_twitch1.84981218
18MP0001501_abnormal_sleep_pattern1.82946556
19MP0005253_abnormal_eye_physiology1.77970089
20MP0002736_abnormal_nociception_after1.77332573
21MP0003718_maternal_effect1.74939037
22MP0001485_abnormal_pinna_reflex1.73711346
23MP0009745_abnormal_behavioral_response1.73345802
24MP0004142_abnormal_muscle_tone1.71630971
25MP0004133_heterotaxia1.71256615
26MP0005389_reproductive_system_phenotype1.68758935
27MP0002160_abnormal_reproductive_system1.66965319
28MP0008875_abnormal_xenobiotic_pharmacok1.64340318
29MP0000372_irregular_coat_pigmentation1.64053681
30MP0002735_abnormal_chemical_nociception1.52412309
31MP0001529_abnormal_vocalization1.49655934
32MP0003136_yellow_coat_color1.49232390
33MP0002653_abnormal_ependyma_morphology1.49152928
34MP0002272_abnormal_nervous_system1.47124427
35MP0004147_increased_porphyrin_level1.42518481
36MP0003787_abnormal_imprinting1.41338712
37MP0002138_abnormal_hepatobiliary_system1.41019968
38MP0004742_abnormal_vestibular_system1.40938682
39MP0000631_abnormal_neuroendocrine_gland1.40283146
40MP0004885_abnormal_endolymph1.33521263
41MP0002876_abnormal_thyroid_physiology1.33187317
42MP0004043_abnormal_pH_regulation1.32154385
43MP0001919_abnormal_reproductive_system1.31421540
44MP0003698_abnormal_male_reproductive1.27979627
45MP0001984_abnormal_olfaction1.27517129
46MP0002938_white_spotting1.27154860
47MP0009764_decreased_sensitivity_to1.26779605
48MP0005084_abnormal_gallbladder_morpholo1.23853095
49MP0001486_abnormal_startle_reflex1.23563552
50MP0006276_abnormal_autonomic_nervous1.23307811
51MP0002733_abnormal_thermal_nociception1.23062749
52MP0001905_abnormal_dopamine_level1.23039008
53MP0001929_abnormal_gametogenesis1.21821756
54MP0005195_abnormal_posterior_eye1.18929015
55MP0005645_abnormal_hypothalamus_physiol1.18439837
56MP0002572_abnormal_emotion/affect_behav1.18385564
57MP0001970_abnormal_pain_threshold1.16020729
58MP0010386_abnormal_urinary_bladder1.14566100
59MP0002210_abnormal_sex_determination1.13635080
60MP0002064_seizures1.12391302
61MP0000049_abnormal_middle_ear1.10511646
62MP0001764_abnormal_homeostasis1.10227244
63MP0004924_abnormal_behavior1.10183226
64MP0005386_behavior/neurological_phenoty1.10183226
65MP0002928_abnormal_bile_duct1.10056585
66MP0002557_abnormal_social/conspecific_i1.05333132
67MP0008995_early_reproductive_senescence1.04431078
68MP0002163_abnormal_gland_morphology1.03986331
69MP0008058_abnormal_DNA_repair1.03131951
70MP0005379_endocrine/exocrine_gland_phen1.01407588
71MP0006035_abnormal_mitochondrial_morpho1.00314896
72MP0002067_abnormal_sensory_capabilities0.98077590
73MP0003635_abnormal_synaptic_transmissio0.95471289
74MP0005174_abnormal_tail_pigmentation0.95191154
75MP0000026_abnormal_inner_ear0.94993254
76MP0005670_abnormal_white_adipose0.94801869
77MP0000653_abnormal_sex_gland0.93595970
78MP0000516_abnormal_urinary_system0.93114674
79MP0005367_renal/urinary_system_phenotyp0.93114674
80MP0008789_abnormal_olfactory_epithelium0.91396458
81MP0003119_abnormal_digestive_system0.89867602
82MP0001324_abnormal_eye_pigmentation0.89362564
83MP0002095_abnormal_skin_pigmentation0.89010786
84MP0004145_abnormal_muscle_electrophysio0.88702948
85MP0002063_abnormal_learning/memory/cond0.88462515
86MP0000230_abnormal_systemic_arterial0.88127050
87MP0002229_neurodegeneration0.86125849
88MP0002752_abnormal_somatic_nervous0.86037452
89MP0001145_abnormal_male_reproductive0.84550749
90MP0004130_abnormal_muscle_cell0.84330310
91MP0000427_abnormal_hair_cycle0.84327544
92MP0004215_abnormal_myocardial_fiber0.83422445
93MP0005167_abnormal_blood-brain_barrier0.83268573
94MP0006036_abnormal_mitochondrial_physio0.82941403
95MP0003252_abnormal_bile_duct0.81071477
96MP0003878_abnormal_ear_physiology0.81066700
97MP0005377_hearing/vestibular/ear_phenot0.81066700
98MP0002734_abnormal_mechanical_nocicepti0.80716732
99MP0001963_abnormal_hearing_physiology0.80229985
100MP0003880_abnormal_central_pattern0.80113164

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.21306687
2Pancreatic fibrosis (HP:0100732)3.88205992
3True hermaphroditism (HP:0010459)3.82961074
4Type II lissencephaly (HP:0007260)3.81981508
5Molar tooth sign on MRI (HP:0002419)3.79690429
6Abnormality of midbrain morphology (HP:0002418)3.79690429
7Congenital stationary night blindness (HP:0007642)3.66691677
8Nephronophthisis (HP:0000090)3.34141501
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.23316079
10Abnormality of alanine metabolism (HP:0010916)3.23316079
11Hyperalaninemia (HP:0003348)3.23316079
12Acute necrotizing encephalopathy (HP:0006965)2.87140614
13Medial flaring of the eyebrow (HP:0010747)2.86599598
14Abnormality of the renal medulla (HP:0100957)2.86583042
15Absent/shortened dynein arms (HP:0200106)2.83793828
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.83793828
17Pendular nystagmus (HP:0012043)2.81659982
18Abnormality of the renal cortex (HP:0011035)2.81541125
19Abnormal respiratory epithelium morphology (HP:0012253)2.69905561
20Abnormal respiratory motile cilium morphology (HP:0005938)2.69905561
21Congenital, generalized hypertrichosis (HP:0004540)2.69680436
22Abolished electroretinogram (ERG) (HP:0000550)2.62454485
23Acute encephalopathy (HP:0006846)2.58366858
24Cystic liver disease (HP:0006706)2.58203379
25Mitochondrial inheritance (HP:0001427)2.57713906
26Hyperventilation (HP:0002883)2.55012267
27Attenuation of retinal blood vessels (HP:0007843)2.54634546
28Abnormal ciliary motility (HP:0012262)2.53124087
29Cerebellar dysplasia (HP:0007033)2.50028431
30Increased CSF lactate (HP:0002490)2.48950720
31Abnormal mitochondria in muscle tissue (HP:0008316)2.48436766
32Retinal dysplasia (HP:0007973)2.43314608
33Progressive macrocephaly (HP:0004481)2.42172210
34Methylmalonic acidemia (HP:0002912)2.39636464
35Chronic hepatic failure (HP:0100626)2.36367467
36Abnormal rod and cone electroretinograms (HP:0008323)2.35189830
37Gait imbalance (HP:0002141)2.32917874
38Sclerocornea (HP:0000647)2.32582918
39Bile duct proliferation (HP:0001408)2.27843323
40Abnormal biliary tract physiology (HP:0012439)2.27843323
41Abnormal respiratory motile cilium physiology (HP:0012261)2.25031149
42Congenital primary aphakia (HP:0007707)2.25011437
433-Methylglutaconic aciduria (HP:0003535)2.24846838
44Bony spicule pigmentary retinopathy (HP:0007737)2.21050275
45Lissencephaly (HP:0001339)2.20448909
46Inability to walk (HP:0002540)2.19569451
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17777589
48Renal cortical cysts (HP:0000803)2.17531797
49Polydipsia (HP:0001959)2.17030610
50Abnormal drinking behavior (HP:0030082)2.17030610
51Increased corneal curvature (HP:0100692)2.16001416
52Keratoconus (HP:0000563)2.16001416
53Concave nail (HP:0001598)2.14965832
54Anencephaly (HP:0002323)2.11759775
55Tubular atrophy (HP:0000092)2.06790963
56Severe muscular hypotonia (HP:0006829)2.06009278
57Chorioretinal atrophy (HP:0000533)2.05743003
58Lipid accumulation in hepatocytes (HP:0006561)2.05712551
59Male pseudohermaphroditism (HP:0000037)2.04715534
60Methylmalonic aciduria (HP:0012120)2.04351296
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.03506611
62Clumsiness (HP:0002312)2.02669325
63Nephrogenic diabetes insipidus (HP:0009806)2.02431458
64Congenital sensorineural hearing impairment (HP:0008527)1.99823916
65Optic disc pallor (HP:0000543)1.98913513
66Abnormality of the pons (HP:0007361)1.98041115
67Genetic anticipation (HP:0003743)1.97990027
68Birth length less than 3rd percentile (HP:0003561)1.97182964
69Hypoplasia of the pons (HP:0012110)1.97070570
70Progressive cerebellar ataxia (HP:0002073)1.95650310
71Pachygyria (HP:0001302)1.95004477
72Hepatocellular necrosis (HP:0001404)1.94945692
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.94158323
74Hepatic necrosis (HP:0002605)1.89947460
75Gaze-evoked nystagmus (HP:0000640)1.89273018
76Stomach cancer (HP:0012126)1.89201715
77Hyperglycinemia (HP:0002154)1.88894044
78Fair hair (HP:0002286)1.88432533
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88399669
80Congenital hepatic fibrosis (HP:0002612)1.88368689
81Aplasia/hypoplasia of the uterus (HP:0008684)1.88311331
82Occipital encephalocele (HP:0002085)1.88011480
83Broad-based gait (HP:0002136)1.86562826
84Absent speech (HP:0001344)1.86501971
85Polyuria (HP:0000103)1.86306816
86Furrowed tongue (HP:0000221)1.84320387
87Increased serum lactate (HP:0002151)1.82054287
88Genital tract atresia (HP:0001827)1.80454409
89Protruding tongue (HP:0010808)1.80318904
90Abnormality of the renal collecting system (HP:0004742)1.80272022
91Vaginal atresia (HP:0000148)1.79757123
92Hypothermia (HP:0002045)1.78094931
93Postaxial foot polydactyly (HP:0001830)1.77622726
94Large for gestational age (HP:0001520)1.77330711
95Retinitis pigmentosa (HP:0000510)1.75459822
96Decreased central vision (HP:0007663)1.74632920
97Absent thumb (HP:0009777)1.74566136
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74328466
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.73425681
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71328465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.77503371
2ZAK3.57249818
3ADRBK23.51605912
4TLK13.11803750
5INSRR2.87696471
6MAP4K22.85177275
7GRK12.79055403
8BMPR1B2.76610949
9TAOK32.67761100
10PINK12.56225355
11NUAK12.43438647
12WNK32.36078966
13ACVR1B2.33716631
14WNK42.29271852
15MAP3K42.23857660
16MAP2K71.95383785
17TXK1.94466769
18MAPK131.92584400
19CASK1.83116821
20OXSR11.63188762
21MARK11.41639600
22PLK41.35024123
23CDK191.31254803
24CAMKK21.26960044
25DAPK21.17882111
26VRK11.08752008
27MKNK21.06822462
28TGFBR11.01169734
29DYRK21.00603610
30GRK70.94644385
31ADRBK10.93059429
32NTRK30.91552794
33PRKCG0.90321096
34TNIK0.89159852
35BCKDK0.86613661
36PLK20.86045730
37RPS6KA50.85500486
38STK390.85463039
39CSNK1G30.84770530
40NTRK20.84065506
41PNCK0.81263340
42TRIM280.80967710
43PDK20.78963556
44CSNK1G10.76025313
45CSNK1G20.75969387
46MAPK150.74737812
47IKBKB0.74716311
48NEK20.73253141
49MAPKAPK30.71016733
50NME10.70682757
51PRKCE0.64827913
52MUSK0.64568402
53PKN10.64048907
54CSNK1A1L0.63675845
55PAK30.60337560
56DYRK30.59588840
57MAP2K10.55217547
58KIT0.54518116
59CSNK1A10.53856501
60STK160.53493710
61BRSK20.52772334
62ERBB30.52095206
63MAPKAPK50.51952294
64PLK10.51457545
65CDC70.49251401
66PRKCI0.48553304
67PRKCQ0.47722682
68PHKG20.47549487
69PHKG10.47549487
70CDK30.47353737
71PRKACA0.47073720
72CAMK2A0.44932797
73STK30.44083045
74TNK20.43164295
75MAP2K60.40428344
76MST40.39440095
77VRK20.38625341
78STK38L0.38518265
79MKNK10.38049274
80* ATR0.37752195
81OBSCN0.37412870
82LYN0.36469949
83PIK3CA0.35915451
84TEC0.35041860
85PLK30.34907951
86PRKG10.34789249
87TIE10.34129539
88CHEK20.33857645
89AURKA0.33482072
90PRKCA0.33066483
91CSNK2A10.32926106
92PTK2B0.32077579
93SYK0.31043395
94PRKAA10.30852814
95SIK20.30738100
96MAP2K40.29464782
97EPHA30.28813514
98IGF1R0.28305627
99PRKAA20.27106489
100MAP2K20.26123492

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.81302216
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57655029
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52591708
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.43037225
5Linoleic acid metabolism_Homo sapiens_hsa005912.38120735
6RNA polymerase_Homo sapiens_hsa030202.30567361
7Butanoate metabolism_Homo sapiens_hsa006502.29220139
8Selenocompound metabolism_Homo sapiens_hsa004502.22549983
9Phototransduction_Homo sapiens_hsa047442.22415237
10Nitrogen metabolism_Homo sapiens_hsa009102.19181166
11Parkinsons disease_Homo sapiens_hsa050122.17669420
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04936427
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04110467
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94722729
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87519329
16Homologous recombination_Homo sapiens_hsa034401.86183136
17Tryptophan metabolism_Homo sapiens_hsa003801.85189536
18Nicotine addiction_Homo sapiens_hsa050331.81437538
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77899304
20Basal transcription factors_Homo sapiens_hsa030221.76911589
21Ether lipid metabolism_Homo sapiens_hsa005651.65483591
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64728108
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.58123689
24Fanconi anemia pathway_Homo sapiens_hsa034601.55267421
25Huntingtons disease_Homo sapiens_hsa050161.55016183
26Protein export_Homo sapiens_hsa030601.52063774
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.42316991
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.41113568
29Alzheimers disease_Homo sapiens_hsa050101.40532735
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40361525
31Peroxisome_Homo sapiens_hsa041461.40321080
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38098676
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36579235
34RNA degradation_Homo sapiens_hsa030181.35465194
35Sulfur metabolism_Homo sapiens_hsa009201.31543053
36Olfactory transduction_Homo sapiens_hsa047401.27620662
37Ribosome_Homo sapiens_hsa030101.26931122
38Taste transduction_Homo sapiens_hsa047421.23627459
39Cardiac muscle contraction_Homo sapiens_hsa042601.22545058
40Proteasome_Homo sapiens_hsa030501.21658128
41Caffeine metabolism_Homo sapiens_hsa002321.17547715
42Chemical carcinogenesis_Homo sapiens_hsa052041.16241868
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15412950
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12447135
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.12187754
46ABC transporters_Homo sapiens_hsa020101.09374510
47Regulation of autophagy_Homo sapiens_hsa041401.09283886
48Propanoate metabolism_Homo sapiens_hsa006401.04235249
49Collecting duct acid secretion_Homo sapiens_hsa049661.03110334
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02977031
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01540420
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99429295
53Asthma_Homo sapiens_hsa053100.98971479
54Morphine addiction_Homo sapiens_hsa050320.92248364
55Retinol metabolism_Homo sapiens_hsa008300.89781102
56Arachidonic acid metabolism_Homo sapiens_hsa005900.87470357
57Pyrimidine metabolism_Homo sapiens_hsa002400.86013648
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84546109
59Purine metabolism_Homo sapiens_hsa002300.83938535
60Steroid biosynthesis_Homo sapiens_hsa001000.80829746
61One carbon pool by folate_Homo sapiens_hsa006700.80775679
62Sulfur relay system_Homo sapiens_hsa041220.79656926
63beta-Alanine metabolism_Homo sapiens_hsa004100.78154673
64Metabolic pathways_Homo sapiens_hsa011000.72810682
65Fat digestion and absorption_Homo sapiens_hsa049750.68846835
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66958325
67GABAergic synapse_Homo sapiens_hsa047270.64680684
68Serotonergic synapse_Homo sapiens_hsa047260.64170057
69Fatty acid biosynthesis_Homo sapiens_hsa000610.62810480
70Systemic lupus erythematosus_Homo sapiens_hsa053220.62590604
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.61357961
72Ovarian steroidogenesis_Homo sapiens_hsa049130.60175957
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59558161
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58936353
75Glycerolipid metabolism_Homo sapiens_hsa005610.58320733
76Vitamin digestion and absorption_Homo sapiens_hsa049770.57640756
77Primary immunodeficiency_Homo sapiens_hsa053400.56032686
78Fatty acid degradation_Homo sapiens_hsa000710.54712231
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54522891
80Rheumatoid arthritis_Homo sapiens_hsa053230.51237173
81Insulin secretion_Homo sapiens_hsa049110.50831844
82Base excision repair_Homo sapiens_hsa034100.48001940
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46188253
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46026178
85Circadian entrainment_Homo sapiens_hsa047130.45992067
86Nucleotide excision repair_Homo sapiens_hsa034200.44518109
87Glutamatergic synapse_Homo sapiens_hsa047240.44058597
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43047907
89Type I diabetes mellitus_Homo sapiens_hsa049400.41624697
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41580630
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39637964
92RNA transport_Homo sapiens_hsa030130.39448345
93Histidine metabolism_Homo sapiens_hsa003400.38788153
94Allograft rejection_Homo sapiens_hsa053300.38135001
95Calcium signaling pathway_Homo sapiens_hsa040200.37488875
96Autoimmune thyroid disease_Homo sapiens_hsa053200.36960213
97Graft-versus-host disease_Homo sapiens_hsa053320.35586059
98Fatty acid metabolism_Homo sapiens_hsa012120.35341951
99Salivary secretion_Homo sapiens_hsa049700.32541600
100Glutathione metabolism_Homo sapiens_hsa004800.31504142

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