ZSCAN30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.73583153
2DNA topological change (GO:0006265)5.26794979
3mitotic sister chromatid cohesion (GO:0007064)5.01780096
4IMP biosynthetic process (GO:0006188)4.50399846
5protein localization to chromosome, centromeric region (GO:0071459)4.42330655
6tryptophan catabolic process (GO:0006569)4.26469414
7indole-containing compound catabolic process (GO:0042436)4.26469414
8indolalkylamine catabolic process (GO:0046218)4.26469414
9DNA ligation (GO:0006266)4.25255665
10ribosomal small subunit assembly (GO:0000028)4.17176494
11sensory perception of smell (GO:0007608)4.16138046
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.07120045
13histone mRNA catabolic process (GO:0071044)4.05059302
14kynurenine metabolic process (GO:0070189)4.04529245
15indolalkylamine metabolic process (GO:0006586)3.99149268
16IMP metabolic process (GO:0046040)3.96031620
17attachment of spindle microtubules to kinetochore (GO:0008608)3.93803149
18neural tube formation (GO:0001841)3.89746355
19positive regulation of gastrulation (GO:2000543)3.89060988
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88551352
21DNA unwinding involved in DNA replication (GO:0006268)3.78792755
22regulation of histone H3-K9 methylation (GO:0051570)3.77302767
23monoubiquitinated protein deubiquitination (GO:0035520)3.75331828
24behavioral response to nicotine (GO:0035095)3.75007311
25Arp2/3 complex-mediated actin nucleation (GO:0034314)3.73246894
26histone H2A acetylation (GO:0043968)3.73138374
27DNA strand elongation involved in DNA replication (GO:0006271)3.72204306
28regulation of DNA damage checkpoint (GO:2000001)3.70351024
29V(D)J recombination (GO:0033151)3.68099317
30folic acid-containing compound biosynthetic process (GO:0009396)3.63843516
31tryptophan metabolic process (GO:0006568)3.63640748
32negative regulation of cytosolic calcium ion concentration (GO:0051481)3.60514113
33protein K11-linked deubiquitination (GO:0035871)3.60395282
34negative regulation of histone methylation (GO:0031061)3.60332204
35establishment of protein localization to Golgi (GO:0072600)3.60218353
36reflex (GO:0060004)3.58331595
37protein insertion into membrane (GO:0051205)3.57878494
38mRNA cleavage (GO:0006379)3.57680080
39detection of light stimulus involved in sensory perception (GO:0050962)3.52494008
40detection of light stimulus involved in visual perception (GO:0050908)3.52494008
41negative regulation of mast cell activation (GO:0033004)3.51006900
42photoreceptor cell maintenance (GO:0045494)3.49590345
43behavioral response to ethanol (GO:0048149)3.47044209
44telomere maintenance via recombination (GO:0000722)3.46457276
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.45945072
46DNA strand elongation (GO:0022616)3.43677292
47negative regulation of phagocytosis (GO:0050765)3.42413362
48telomere maintenance via semi-conservative replication (GO:0032201)3.40635181
49viral mRNA export from host cell nucleus (GO:0046784)3.39503925
50gamma-aminobutyric acid transport (GO:0015812)3.37171807
51cilium or flagellum-dependent cell motility (GO:0001539)3.36779538
52signal peptide processing (GO:0006465)3.36583744
53auditory receptor cell stereocilium organization (GO:0060088)3.34806293
54mitotic recombination (GO:0006312)3.33690228
55regulation of chromatin binding (GO:0035561)3.30726178
56negative regulation of fatty acid transport (GO:2000192)3.27824082
57positive regulation of developmental pigmentation (GO:0048087)3.27530756
58formation of translation preinitiation complex (GO:0001731)3.26985942
59establishment of integrated proviral latency (GO:0075713)3.26513071
60tachykinin receptor signaling pathway (GO:0007217)3.26239543
61regulation of protein heterodimerization activity (GO:0043497)3.22518390
62regulation of pigment cell differentiation (GO:0050932)3.21860315
63interkinetic nuclear migration (GO:0022027)3.19082613
64regulation of hippo signaling (GO:0035330)3.15644146
65regulation of sarcomere organization (GO:0060297)3.15586400
66indole-containing compound metabolic process (GO:0042430)3.13304546
67mismatch repair (GO:0006298)3.12703825
68L-fucose catabolic process (GO:0042355)3.10279699
69fucose catabolic process (GO:0019317)3.10279699
70L-fucose metabolic process (GO:0042354)3.10279699
71metaphase plate congression (GO:0051310)3.08125835
72nonmotile primary cilium assembly (GO:0035058)3.07612199
73histone mRNA metabolic process (GO:0008334)3.07559419
74benzene-containing compound metabolic process (GO:0042537)3.04680241
75inner ear receptor stereocilium organization (GO:0060122)3.03838335
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.01727881
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01727881
78establishment of chromosome localization (GO:0051303)3.00372669
79righting reflex (GO:0060013)2.99455200
80serotonin metabolic process (GO:0042428)2.99341365
81Golgi transport vesicle coating (GO:0048200)2.98506227
82COPI coating of Golgi vesicle (GO:0048205)2.98506227
83sulfation (GO:0051923)2.98495753
84snRNA transcription (GO:0009301)2.97168074
85presynaptic membrane assembly (GO:0097105)2.96153930
86mitotic chromosome condensation (GO:0007076)2.95588142
87kinetochore organization (GO:0051383)2.94028236
88nucleobase biosynthetic process (GO:0046112)2.93390748
89protein K48-linked deubiquitination (GO:0071108)2.92780443
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91489533
91actin nucleation (GO:0045010)2.91045757
92spindle assembly checkpoint (GO:0071173)2.90832098
93primary amino compound metabolic process (GO:1901160)2.89701907
94antigen processing and presentation of endogenous antigen (GO:0019883)2.88384332
95positive regulation of RNA splicing (GO:0033120)2.87322722
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86794428
97intra-S DNA damage checkpoint (GO:0031573)2.85697149
98regulation of gene silencing by RNA (GO:0060966)2.85566127
99regulation of posttranscriptional gene silencing (GO:0060147)2.85566127
100regulation of gene silencing by miRNA (GO:0060964)2.85566127
101nucleotide-excision repair, DNA gap filling (GO:0006297)2.85154890
102protein localization to cilium (GO:0061512)2.84923767
103protein localization to chromosome (GO:0034502)2.84921213
104pyrimidine nucleobase catabolic process (GO:0006208)2.84470429
105dosage compensation (GO:0007549)2.84430083
106axoneme assembly (GO:0035082)2.84007814
107base-excision repair (GO:0006284)2.83573744
108negative regulation of translation, ncRNA-mediated (GO:0040033)2.82383005
109regulation of translation, ncRNA-mediated (GO:0045974)2.82383005
110negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82383005
111central nervous system neuron axonogenesis (GO:0021955)2.81925388
112sister chromatid segregation (GO:0000819)2.81432989
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80509398
114somatic cell DNA recombination (GO:0016444)2.80114053
115somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.80114053
116meiotic chromosome segregation (GO:0045132)2.79443081
117positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.78717020
118thyroid hormone metabolic process (GO:0042403)2.76677070
119phospholipid translocation (GO:0045332)2.75611652
120lipid translocation (GO:0034204)2.75611652
121cilium organization (GO:0044782)2.75606740
122secretory granule organization (GO:0033363)2.75239944
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74384704
124membrane depolarization during action potential (GO:0086010)2.73441811
125oxygen transport (GO:0015671)2.73121318
126regulation of histone H3-K4 methylation (GO:0051569)2.73029649
127startle response (GO:0001964)2.72644715
128cilium assembly (GO:0042384)2.72135341
129detection of mechanical stimulus involved in sensory perception (GO:0050974)2.71861479
130nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.71771222
131cellular ketone body metabolic process (GO:0046950)2.71767617
132DNA replication initiation (GO:0006270)2.71370339
133protein polyglutamylation (GO:0018095)2.71194665
134mitotic metaphase plate congression (GO:0007080)2.70619046
135neuronal action potential (GO:0019228)2.67518671
136positive regulation of oligodendrocyte differentiation (GO:0048714)2.67084293
137regulation of hexokinase activity (GO:1903299)2.65616087
138regulation of glucokinase activity (GO:0033131)2.65616087
139retinal cone cell development (GO:0046549)2.65554358
140cilium morphogenesis (GO:0060271)2.65514640
141regulation of establishment of cell polarity (GO:2000114)2.65341492
142cellular response to sterol (GO:0036315)2.65332490
143alternative mRNA splicing, via spliceosome (GO:0000380)2.65042623
144cellular hyperosmotic response (GO:0071474)2.64272932
145regulation of collateral sprouting (GO:0048670)2.63220251
146cellular biogenic amine catabolic process (GO:0042402)2.62997479
147amine catabolic process (GO:0009310)2.62997479
148non-recombinational repair (GO:0000726)2.61661600
149double-strand break repair via nonhomologous end joining (GO:0006303)2.61661600
150snRNA processing (GO:0016180)2.61493178
151oxidative demethylation (GO:0070989)2.61433296
152glucocorticoid receptor signaling pathway (GO:0042921)2.61163537
153spindle checkpoint (GO:0031577)2.61116935
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.60816645
155regulation of centriole replication (GO:0046599)2.60723246
156protein K63-linked deubiquitination (GO:0070536)2.60713853
157central nervous system projection neuron axonogenesis (GO:0021952)2.60357797
1583-UTR-mediated mRNA stabilization (GO:0070935)2.60058906
159regulation of chromosome segregation (GO:0051983)2.59626348
160ATP-dependent chromatin remodeling (GO:0043044)2.59152055
161natural killer cell mediated immunity (GO:0002228)2.59049921
162natural killer cell mediated cytotoxicity (GO:0042267)2.59049921
163presynaptic membrane organization (GO:0097090)2.58502797
164protein prenylation (GO:0018342)2.58065516
165prenylation (GO:0097354)2.58065516
166ncRNA catabolic process (GO:0034661)2.56154011
167CENP-A containing nucleosome assembly (GO:0034080)2.54523898
168negative regulation of gene expression, epigenetic (GO:0045814)2.54277491
169somatic diversification of immune receptors via somatic mutation (GO:0002566)2.54127441
170somatic hypermutation of immunoglobulin genes (GO:0016446)2.54127441
171RNA export from nucleus (GO:0006405)2.53864884
172mitotic nuclear envelope disassembly (GO:0007077)2.53593132
173appendage development (GO:0048736)2.53394638
174limb development (GO:0060173)2.53394638
175response to pheromone (GO:0019236)2.52938417
176negative regulation of systemic arterial blood pressure (GO:0003085)2.52849719
177DNA demethylation (GO:0080111)2.51743643
178regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51648336
179mitotic spindle assembly checkpoint (GO:0007094)2.51607460
180response to misfolded protein (GO:0051788)2.51320956
181cellular response to prostaglandin stimulus (GO:0071379)2.51274366
182DNA duplex unwinding (GO:0032508)2.50441404
183replication fork processing (GO:0031297)2.50426978
184sister chromatid cohesion (GO:0007062)2.50367002
185lateral ventricle development (GO:0021670)2.49827788
186nucleobase catabolic process (GO:0046113)2.49429885
187mitotic sister chromatid segregation (GO:0000070)2.48485044
188translational elongation (GO:0006414)2.48210218
189NAD biosynthetic process (GO:0009435)2.47930495
190cAMP catabolic process (GO:0006198)2.47855984
191response to nitrosative stress (GO:0051409)2.46894650
192DNA geometric change (GO:0032392)2.46783495
193purine nucleobase biosynthetic process (GO:0009113)2.46530096
194negative regulation of sodium ion transport (GO:0010766)2.46245136
195phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.46229209
196adaptation of signaling pathway (GO:0023058)2.44258181
197protein targeting to Golgi (GO:0000042)2.41803840
198ketone body metabolic process (GO:1902224)2.40505722
199transmission of nerve impulse (GO:0019226)2.40019941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.83012446
2GBX2_23144817_ChIP-Seq_PC3_Human3.94074824
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.47609770
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30246398
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.22957669
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20419950
7MYC_22102868_ChIP-Seq_BL_Human2.90628655
8EZH2_22144423_ChIP-Seq_EOC_Human2.86655076
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.84062761
10IGF1R_20145208_ChIP-Seq_DFB_Human2.81677949
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80959172
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78038907
13CIITA_25753668_ChIP-Seq_RAJI_Human2.75196219
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74893556
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74161747
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71941890
17ZNF274_21170338_ChIP-Seq_K562_Hela2.71794702
18VDR_22108803_ChIP-Seq_LS180_Human2.66974133
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63741222
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58913460
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.56455663
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53488581
23TAF15_26573619_Chip-Seq_HEK293_Human2.39546685
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39258763
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37942818
26SCL_19346495_ChIP-Seq_HPC-7_Human2.34518285
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.34364218
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28153754
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.21121824
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.17139994
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16876234
32XRN2_22483619_ChIP-Seq_HELA_Human2.14620356
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08944395
34P300_19829295_ChIP-Seq_ESCs_Human2.08562835
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.07568437
36FLI1_27457419_Chip-Seq_LIVER_Mouse2.05570668
37VDR_23849224_ChIP-Seq_CD4+_Human2.04602065
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03459275
39SALL1_21062744_ChIP-ChIP_HESCs_Human2.03418692
40AR_21909140_ChIP-Seq_LNCAP_Human2.01086094
41FUS_26573619_Chip-Seq_HEK293_Human1.98443672
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.96411690
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96211624
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94735975
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.93196763
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92897877
47STAT3_23295773_ChIP-Seq_U87_Human1.91497854
48EWS_26573619_Chip-Seq_HEK293_Human1.90212751
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89674795
50SMAD4_21799915_ChIP-Seq_A2780_Human1.89655998
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89191741
52VDR_21846776_ChIP-Seq_THP-1_Human1.86480530
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84850759
54ER_23166858_ChIP-Seq_MCF-7_Human1.84736986
55GATA1_22025678_ChIP-Seq_K562_Human1.81957897
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75771991
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72097476
58TCF4_23295773_ChIP-Seq_U87_Human1.71324109
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.70714640
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70701438
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68993979
62FOXP3_21729870_ChIP-Seq_TREG_Human1.66824182
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66628595
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66109095
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64434854
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64194976
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63952769
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63798869
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63444205
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62947506
71TTF2_22483619_ChIP-Seq_HELA_Human1.62478542
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62299121
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.62087903
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60484912
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60192624
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.59583010
77AR_25329375_ChIP-Seq_VCAP_Human1.59461827
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58788179
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58006792
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57078899
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56210291
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55539799
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55539799
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55508544
85BCAT_22108803_ChIP-Seq_LS180_Human1.55198894
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54810699
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53715636
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53673671
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53105133
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.52827751
91AR_21572438_ChIP-Seq_LNCaP_Human1.52596716
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52392308
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52239775
94MYB_26560356_Chip-Seq_TH2_Human1.51133963
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50447211
96CBP_20019798_ChIP-Seq_JUKART_Human1.50198491
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50198491
98TP53_16413492_ChIP-PET_HCT116_Human1.48717729
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48454732
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47306176
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43312637
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42666486
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41987324
104GABP_19822575_ChIP-Seq_HepG2_Human1.41540452
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.38907842
106SPI1_23547873_ChIP-Seq_NB4_Human1.38711386
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38420451
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37969022
109VDR_24763502_ChIP-Seq_THP-1_Human1.36985585
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36717766
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35608266
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.35561757
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35342921
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34832963
115ELK1_19687146_ChIP-ChIP_HELA_Human1.34598861
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34308210
117RUNX2_22187159_ChIP-Seq_PCA_Human1.33827368
118IRF1_19129219_ChIP-ChIP_H3396_Human1.33414347
119TCF7_22412390_ChIP-Seq_EML_Mouse1.33083511
120E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32703024
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.32599892
122DROSHA_22980978_ChIP-Seq_HELA_Human1.32472401
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.31922938
124REST_21632747_ChIP-Seq_MESCs_Mouse1.31695163
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30684654
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30664293
127FLI1_21867929_ChIP-Seq_TH2_Mouse1.30566264
128TCF4_22108803_ChIP-Seq_LS180_Human1.27858103
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27644358
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27372321
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.26954843
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25668149
133PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24577461
134NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23542351
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21816434
136SMAD4_21741376_ChIP-Seq_EPCs_Human1.21722589
137DCP1A_22483619_ChIP-Seq_HELA_Human1.21447511
138NFE2_27457419_Chip-Seq_LIVER_Mouse1.21446129
139MAF_26560356_Chip-Seq_TH1_Human1.20935763
140UTX_26944678_Chip-Seq_JUKART_Human1.20785966
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20227763
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20210035
143KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20053137
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19807102
145RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19618603
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19131920
147NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19097894
148RNF2_27304074_Chip-Seq_NSC_Mouse1.18929499
149SOX2_21211035_ChIP-Seq_LN229_Gbm1.18492383
150ARNT_22903824_ChIP-Seq_MCF-7_Human1.17880520
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17861158
152MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17658753
153MYB_26560356_Chip-Seq_TH1_Human1.17505354
154ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16769514
155NANOG_19829295_ChIP-Seq_ESCs_Human1.16726504
156SOX2_19829295_ChIP-Seq_ESCs_Human1.16726504
157RUNX1_22412390_ChIP-Seq_EML_Mouse1.16224338
158SMAD_19615063_ChIP-ChIP_OVARY_Human1.16035747
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14712940
160CRX_20693478_ChIP-Seq_RETINA_Mouse1.13794148
161TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11891359
162P53_22387025_ChIP-Seq_ESCs_Mouse1.11840966
163* TP53_22573176_ChIP-Seq_HFKS_Human1.11313550
164KDM5A_27292631_Chip-Seq_BREAST_Human1.10685791
165SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10524371
166RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10292531
167SRF_21415370_ChIP-Seq_HL-1_Mouse1.09794571
168E2F1_18555785_Chip-Seq_ESCs_Mouse1.09561305
169OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08836372
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07690099
171KDM2B_26808549_Chip-Seq_REH_Human1.07295831
172PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07155828
173TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06246426
174AHR_22903824_ChIP-Seq_MCF-7_Human1.05730420
175TFEB_21752829_ChIP-Seq_HELA_Human1.05605103
176TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05291867
177CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04310069
178FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03684094
179KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03427041
180ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03087698
181BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02325239
182CDX2_22108803_ChIP-Seq_LS180_Human1.02173549
183IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02058524
184GATA3_27048872_Chip-Seq_THYMUS_Human1.01694887
185CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01673958
186CHD1_26751641_Chip-Seq_LNCaP_Human1.01634194
187STAT3_18555785_Chip-Seq_ESCs_Mouse1.00996120
188SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00986184
189SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00936464
190NOTCH1_21737748_ChIP-Seq_TLL_Human0.99284339
191FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98986247
192KDM2B_26808549_Chip-Seq_DND41_Human0.98815649
193STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98582836
194FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97505949
195CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96671794
196DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95773936
197GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95146703
198NANOG_21062744_ChIP-ChIP_HESCs_Human0.94037220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.78693983
2MP0000569_abnormal_digit_pigmentation5.10537266
3MP0003122_maternal_imprinting3.68537788
4MP0003121_genomic_imprinting3.19709857
5MP0010094_abnormal_chromosome_stability3.09271288
6MP0002396_abnormal_hematopoietic_system3.05346316
7MP0002166_altered_tumor_susceptibility3.03628309
8MP0003787_abnormal_imprinting2.93615325
9MP0003195_calcinosis2.82015029
10MP0003693_abnormal_embryo_hatching2.72137759
11MP0003111_abnormal_nucleus_morphology2.68594620
12MP0005551_abnormal_eye_electrophysiolog2.62165721
13MP0003123_paternal_imprinting2.54278037
14MP0002009_preneoplasia2.50967219
15MP0001968_abnormal_touch/_nociception2.45387297
16MP0009046_muscle_twitch2.41972422
17MP0005174_abnormal_tail_pigmentation2.37167792
18MP0003646_muscle_fatigue2.32106739
19MP0001501_abnormal_sleep_pattern2.31244346
20MP0002736_abnormal_nociception_after2.31225536
21MP0004043_abnormal_pH_regulation2.25992887
22MP0002735_abnormal_chemical_nociception2.21848210
23MP0003077_abnormal_cell_cycle2.15606398
24MP0006276_abnormal_autonomic_nervous2.04519103
25MP0000427_abnormal_hair_cycle2.02278394
26MP0003880_abnormal_central_pattern2.02267611
27MP0000383_abnormal_hair_follicle2.00262081
28MP0009745_abnormal_behavioral_response1.93468096
29MP0002837_dystrophic_cardiac_calcinosis1.92313671
30MP0002006_tumorigenesis1.92239697
31MP0005646_abnormal_pituitary_gland1.92102625
32MP0001486_abnormal_startle_reflex1.86844191
33MP0003172_abnormal_lysosome_physiology1.84891933
34MP0001545_abnormal_hematopoietic_system1.80689807
35MP0005397_hematopoietic_system_phenotyp1.80689807
36MP0004957_abnormal_blastocyst_morpholog1.77918834
37MP0008058_abnormal_DNA_repair1.77758351
38MP0001835_abnormal_antigen_presentation1.74944096
39MP0004808_abnormal_hematopoietic_stem1.74051702
40MP0002102_abnormal_ear_morphology1.72414686
41MP0002272_abnormal_nervous_system1.69297943
42MP0005253_abnormal_eye_physiology1.69252473
43MP0003763_abnormal_thymus_physiology1.69021230
44MP0008007_abnormal_cellular_replicative1.65725791
45MP0003942_abnormal_urinary_system1.61682583
46MP0002572_abnormal_emotion/affect_behav1.57720850
47MP0004145_abnormal_muscle_electrophysio1.56756131
48MP0004742_abnormal_vestibular_system1.55825502
49MP0004142_abnormal_muscle_tone1.55749314
50MP0008872_abnormal_physiological_respon1.54643296
51MP0002398_abnormal_bone_marrow1.53418239
52MP0003567_abnormal_fetal_cardiomyocyte1.51171653
53MP0003635_abnormal_synaptic_transmissio1.47741601
54MP0000350_abnormal_cell_proliferation1.47289215
55MP0002733_abnormal_thermal_nociception1.46501221
56MP0001970_abnormal_pain_threshold1.43909488
57MP0002064_seizures1.43907137
58MP0002067_abnormal_sensory_capabilities1.42179347
59MP0000631_abnormal_neuroendocrine_gland1.41518567
60MP0000703_abnormal_thymus_morphology1.39248804
61MP0006292_abnormal_olfactory_placode1.37480279
62MP0005386_behavior/neurological_phenoty1.35812173
63MP0004924_abnormal_behavior1.35812173
64MP0002163_abnormal_gland_morphology1.35090383
65MP0002734_abnormal_mechanical_nocicepti1.31999481
66MP0005220_abnormal_exocrine_pancreas1.31925028
67MP0001348_abnormal_lacrimal_gland1.30736847
68MP0003136_yellow_coat_color1.30058092
69MP0002557_abnormal_social/conspecific_i1.29737974
70MP0002063_abnormal_learning/memory/cond1.28326782
71MP0000778_abnormal_nervous_system1.27017768
72MP0008057_abnormal_DNA_replication1.26861772
73MP0010386_abnormal_urinary_bladder1.25318230
74MP0006072_abnormal_retinal_apoptosis1.25093130
75MP0004885_abnormal_endolymph1.24271384
76MP0002638_abnormal_pupillary_reflex1.21662270
77MP0002876_abnormal_thyroid_physiology1.21061941
78MP0000490_abnormal_crypts_of1.20718269
79MP0003183_abnormal_peptide_metabolism1.19956646
80MP0000716_abnormal_immune_system1.18018569
81MP0008961_abnormal_basal_metabolism1.15635304
82MP0009333_abnormal_splenocyte_physiolog1.15225358
83MP0010030_abnormal_orbit_morphology1.14389964
84MP0002429_abnormal_blood_cell1.14165682
85MP0004215_abnormal_myocardial_fiber1.13283327
86MP0005075_abnormal_melanosome_morpholog1.11276708
87MP0005645_abnormal_hypothalamus_physiol1.09649982
88MP0001986_abnormal_taste_sensitivity1.09194306
89MP0002019_abnormal_tumor_incidence1.09016240
90MP0002722_abnormal_immune_system1.08786787
91MP0004147_increased_porphyrin_level1.08612451
92MP0002928_abnormal_bile_duct1.08117293
93MP0000015_abnormal_ear_pigmentation1.07593142
94MP0009278_abnormal_bone_marrow1.07419428
95MP0004130_abnormal_muscle_cell1.06254735
96MP0000516_abnormal_urinary_system1.05755702
97MP0005367_renal/urinary_system_phenotyp1.05755702
98MP0010678_abnormal_skin_adnexa1.04914373
99MP0004859_abnormal_synaptic_plasticity1.02342726
100MP0000689_abnormal_spleen_morphology1.02263070
101MP0002095_abnormal_skin_pigmentation1.02073450
102MP0004197_abnormal_fetal_growth/weight/1.01388304
103MP0003137_abnormal_impulse_conducting1.01097312
104MP0009053_abnormal_anal_canal1.01020697
105MP0002184_abnormal_innervation1.00655014
106MP0005171_absent_coat_pigmentation0.99759605
107MP0000230_abnormal_systemic_arterial0.99413314
108MP0002420_abnormal_adaptive_immunity0.99403723
109MP0005310_abnormal_salivary_gland0.98758426
110MP0002234_abnormal_pharynx_morphology0.98585993
111MP0003045_fibrosis0.98516715
112MP0001819_abnormal_immune_cell0.98366529
113MP0005076_abnormal_cell_differentiation0.97697467
114MP0003984_embryonic_growth_retardation0.97405948
115MP0003890_abnormal_embryonic-extraembry0.97375070
116MP0000372_irregular_coat_pigmentation0.96034629
117MP0005464_abnormal_platelet_physiology0.95417502
118MP0002088_abnormal_embryonic_growth/wei0.95240806
119MP0010352_gastrointestinal_tract_polyps0.95144181
120MP0004085_abnormal_heartbeat0.95135304
121MP0005670_abnormal_white_adipose0.94527914
122MP0005167_abnormal_blood-brain_barrier0.94303322
123MP0003633_abnormal_nervous_system0.94071194
124MP0002229_neurodegeneration0.93218623
125MP0002080_prenatal_lethality0.91919875
126MP0002938_white_spotting0.91547245
127MP0000537_abnormal_urethra_morphology0.91538044
128MP0001529_abnormal_vocalization0.91413851
129MP0002752_abnormal_somatic_nervous0.91370519
130MP0003252_abnormal_bile_duct0.89654493
131MP0002882_abnormal_neuron_morphology0.89538701
132MP0001672_abnormal_embryogenesis/_devel0.89004241
133MP0005380_embryogenesis_phenotype0.89004241
134MP0002138_abnormal_hepatobiliary_system0.88356822
135MP0002084_abnormal_developmental_patter0.86971275
136MP0006054_spinal_hemorrhage0.86948391
137MP0001730_embryonic_growth_arrest0.86899994
138MP0002452_abnormal_antigen_presenting0.86602902
139MP0005195_abnormal_posterior_eye0.86427659
140MP0001697_abnormal_embryo_size0.85941784
141MP0003943_abnormal_hepatobiliary_system0.85738190
142MP0009672_abnormal_birth_weight0.85245829
143MP0005384_cellular_phenotype0.85177930
144MP0008932_abnormal_embryonic_tissue0.85144335
145MP0005379_endocrine/exocrine_gland_phen0.84766858
146MP0004264_abnormal_extraembryonic_tissu0.84315324
147MP0000647_abnormal_sebaceous_gland0.83451583
148MP0003698_abnormal_male_reproductive0.82746017
149MP0000049_abnormal_middle_ear0.82633512
150MP0001963_abnormal_hearing_physiology0.82289534
151MP0002877_abnormal_melanocyte_morpholog0.82058183
152MP0000534_abnormal_ureter_morphology0.81337145
153MP0005423_abnormal_somatic_nervous0.80754895
154MP0000955_abnormal_spinal_cord0.80590512
155MP0002168_other_aberrant_phenotype0.80572134
156MP0000313_abnormal_cell_death0.79943770
157MP0000026_abnormal_inner_ear0.79238367
158MP0003566_abnormal_cell_adhesion0.78110978
159MP0000685_abnormal_immune_system0.77228541
160MP0000371_diluted_coat_color0.76826422
161MP0001485_abnormal_pinna_reflex0.76787508
162MP0001800_abnormal_humoral_immune0.76341793
163MP0002090_abnormal_vision0.75542780
164MP0008775_abnormal_heart_ventricle0.73693663
165MP0002085_abnormal_embryonic_tissue0.72498971
166MP0008877_abnormal_DNA_methylation0.72089798
167MP0002933_joint_inflammation0.71919839
168MP0005377_hearing/vestibular/ear_phenot0.71708494
169MP0003878_abnormal_ear_physiology0.71708494
170MP0005621_abnormal_cell_physiology0.70761628
171MP0001790_abnormal_immune_system0.70579354
172MP0005387_immune_system_phenotype0.70579354
173MP0005389_reproductive_system_phenotype0.70380231
174MP0002086_abnormal_extraembryonic_tissu0.70259722
175MP0009703_decreased_birth_body0.70146279
176MP0002419_abnormal_innate_immunity0.70027192
177MP0000465_gastrointestinal_hemorrhage0.69753001
178MP0003303_peritoneal_inflammation0.69534503
179MP0001873_stomach_inflammation0.68573424
180MP0000858_altered_metastatic_potential0.67009003
181MP0002751_abnormal_autonomic_nervous0.65919897
182MP0004133_heterotaxia0.65323261
183MP0001119_abnormal_female_reproductive0.64811904
184MP0003436_decreased_susceptibility_to0.64099657
185MP0003221_abnormal_cardiomyocyte_apopto0.64013480

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.03305204
2Elevated erythrocyte sedimentation rate (HP:0003565)4.71079242
3Genetic anticipation (HP:0003743)4.42972515
4Abnormality of the fingertips (HP:0001211)4.30795693
5Gaze-evoked nystagmus (HP:0000640)3.91150971
6Progressive cerebellar ataxia (HP:0002073)3.87445605
7Volvulus (HP:0002580)3.76056694
8Colon cancer (HP:0003003)3.65955849
9Thrombocytosis (HP:0001894)3.63395066
10Ependymoma (HP:0002888)3.60750019
11Nephronophthisis (HP:0000090)3.55759927
12Hand muscle atrophy (HP:0009130)3.41067590
13Abnormal foot bone ossification (HP:0010675)3.37641387
14Abnormality of the renal cortex (HP:0011035)3.34455607
15Medial flaring of the eyebrow (HP:0010747)3.33954597
16Abnormality of the renal medulla (HP:0100957)3.33890471
17Chronic hepatic failure (HP:0100626)3.27063860
18Congenital stationary night blindness (HP:0007642)3.26945257
19Protruding tongue (HP:0010808)3.20447991
20Peritonitis (HP:0002586)3.18937224
21Abnormality of midbrain morphology (HP:0002418)3.16419559
22Molar tooth sign on MRI (HP:0002419)3.16419559
23Abnormal tarsal ossification (HP:0008369)3.15812432
24Absent speech (HP:0001344)3.15150499
25Metaphyseal dysplasia (HP:0100255)3.14954565
26Aplasia/Hypoplasia of the tibia (HP:0005772)3.11661896
27Attenuation of retinal blood vessels (HP:0007843)3.07498180
28Panhypogammaglobulinemia (HP:0003139)3.05693749
29Cystic liver disease (HP:0006706)3.00910798
30Gait imbalance (HP:0002141)3.00194572
31Congenital primary aphakia (HP:0007707)2.93212733
32Arthropathy (HP:0003040)2.89279964
33Agnosia (HP:0010524)2.85992876
34Type II lissencephaly (HP:0007260)2.82295539
35Congenital sensorineural hearing impairment (HP:0008527)2.80632804
36Broad-based gait (HP:0002136)2.80090799
37Abolished electroretinogram (ERG) (HP:0000550)2.78032467
38Recurrent viral infections (HP:0004429)2.74268275
39Clumsiness (HP:0002312)2.72928401
40Cerebellar dysplasia (HP:0007033)2.71160827
41Ankle clonus (HP:0011448)2.70449133
42Nephrogenic diabetes insipidus (HP:0009806)2.66171303
43Fatigue (HP:0012378)2.63472775
44Genital tract atresia (HP:0001827)2.61372960
45Upper limb amyotrophy (HP:0009129)2.60775570
46Distal upper limb amyotrophy (HP:0007149)2.60775570
47Diastasis recti (HP:0001540)2.60740316
48Febrile seizures (HP:0002373)2.58410322
49Hypothermia (HP:0002045)2.57442321
50Increased number of teeth (HP:0011069)2.56422823
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.55485844
52Fair hair (HP:0002286)2.50164348
53Focal seizures (HP:0007359)2.48498257
54Renal cortical cysts (HP:0000803)2.48454879
55Hyperacusis (HP:0010780)2.47483980
56Vaginal atresia (HP:0000148)2.46946882
57Inability to walk (HP:0002540)2.45792474
58Tubular atrophy (HP:0000092)2.44032707
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.42835754
60Broad palm (HP:0001169)2.40070201
61Renal duplication (HP:0000075)2.37866217
62Syringomyelia (HP:0003396)2.37522541
63Spinal cord lesions (HP:0100561)2.37522541
64Decreased circulating renin level (HP:0003351)2.36464016
65Pancreatic fibrosis (HP:0100732)2.36321058
66Abnormality of the peritoneum (HP:0002585)2.35951220
67Prominent metopic ridge (HP:0005487)2.32990243
68Increased nuchal translucency (HP:0010880)2.32713701
69Bony spicule pigmentary retinopathy (HP:0007737)2.31806800
70Polydipsia (HP:0001959)2.30745091
71Abnormal drinking behavior (HP:0030082)2.30745091
72Poor coordination (HP:0002370)2.30017921
73Congenital hepatic fibrosis (HP:0002612)2.27138418
74Hypoplasia of the thymus (HP:0000778)2.26818254
75Postaxial foot polydactyly (HP:0001830)2.25109088
76Lissencephaly (HP:0001339)2.24919399
77Hemiparesis (HP:0001269)2.24839061
78Pseudobulbar signs (HP:0002200)2.22971813
79Hypoplastic ischia (HP:0003175)2.21951044
80Optic nerve coloboma (HP:0000588)2.21293317
81Gastrointestinal infarctions (HP:0005244)2.21072394
82Furrowed tongue (HP:0000221)2.20888180
83Sclerocornea (HP:0000647)2.20428897
84Abnormality of the metopic suture (HP:0005556)2.18411413
85Focal motor seizures (HP:0011153)2.18306772
86Cutaneous melanoma (HP:0012056)2.17949095
87Abnormality of the lower motor neuron (HP:0002366)2.17727816
88Amaurosis fugax (HP:0100576)2.17577496
89Pancreatic cysts (HP:0001737)2.17332053
90Palpitations (HP:0001962)2.17217408
91Short foot (HP:0001773)2.15128578
92Dialeptic seizures (HP:0011146)2.14711080
93Drooling (HP:0002307)2.14537721
94Progressive inability to walk (HP:0002505)2.13766694
95True hermaphroditism (HP:0010459)2.13763949
96Myositis (HP:0100614)2.12598865
97Widely spaced teeth (HP:0000687)2.12116472
98Abnormality of the astrocytes (HP:0100707)2.09875140
99Astrocytoma (HP:0009592)2.09875140
100Retrobulbar optic neuritis (HP:0100654)2.09556466
101Optic neuritis (HP:0100653)2.09556466
102Abnormality of the ischium (HP:0003174)2.08350564
103Keratoconus (HP:0000563)2.08226214
104Increased corneal curvature (HP:0100692)2.08226214
105Stomach cancer (HP:0012126)2.07960337
106Abnormal biliary tract physiology (HP:0012439)2.07170344
107Bile duct proliferation (HP:0001408)2.07170344
108Chest pain (HP:0100749)2.06211410
109Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05433164
110Metaphyseal cupping (HP:0003021)2.04746817
111Small hand (HP:0200055)2.04324588
112Anencephaly (HP:0002323)2.03201286
113Neuroendocrine neoplasm (HP:0100634)2.03184006
114Hyperalaninemia (HP:0003348)2.02240463
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02240463
116Abnormality of alanine metabolism (HP:0010916)2.02240463
117Hepatoblastoma (HP:0002884)2.01553053
118Tongue fasciculations (HP:0001308)2.01424453
119Cortical dysplasia (HP:0002539)2.00540507
120Central scotoma (HP:0000603)2.00359027
121Preaxial foot polydactyly (HP:0001841)2.00321096
122Large for gestational age (HP:0001520)1.99829618
123Broad phalanges of the hand (HP:0009768)1.99533196
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99270908
125Orchitis (HP:0100796)1.97866673
126Nephroblastoma (Wilms tumor) (HP:0002667)1.96874442
127Short 5th finger (HP:0009237)1.95868689
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.94810087
129Pancreatic islet-cell hyperplasia (HP:0004510)1.93867364
130Patellar aplasia (HP:0006443)1.93256788
131Excessive salivation (HP:0003781)1.91797442
132Deep philtrum (HP:0002002)1.91479330
133Generalized hypopigmentation of hair (HP:0011358)1.90289987
134Male pseudohermaphroditism (HP:0000037)1.90253869
135Mild short stature (HP:0003502)1.88355685
136Hypoplastic labia majora (HP:0000059)1.88133917
137Broad alveolar ridges (HP:0000187)1.87740174
138Renovascular hypertension (HP:0100817)1.86479215
139Truncal obesity (HP:0001956)1.86437768
140Thyroid-stimulating hormone excess (HP:0002925)1.85806031
141Broad phalanx (HP:0006009)1.84797232
142Abnormality of the calcaneus (HP:0008364)1.84257091
143Broad finger (HP:0001500)1.84197701
144Abnormality of carpal bone ossification (HP:0006257)1.83329845
145B lymphocytopenia (HP:0010976)1.83038454
146Abnormality of B cell number (HP:0010975)1.83038454
147Postaxial hand polydactyly (HP:0001162)1.82446964
148Thyroiditis (HP:0100646)1.80353839
149Retinitis pigmentosa (HP:0000510)1.79539789
150Abnormal hair whorl (HP:0010721)1.79295921
151Biliary tract neoplasm (HP:0100574)1.79129494
152Urinary bladder sphincter dysfunction (HP:0002839)1.78800915
15311 pairs of ribs (HP:0000878)1.78773133
154Broad foot (HP:0001769)1.78645654
155Preaxial hand polydactyly (HP:0001177)1.77297953
156Amyloidosis (HP:0011034)1.77255106
157Neoplasm of the adrenal gland (HP:0100631)1.77199351
158Retinal dysplasia (HP:0007973)1.77145180
159Aplasia/Hypoplasia of the patella (HP:0006498)1.76915057
160Tubulointerstitial nephritis (HP:0001970)1.76714826
161Embryonal renal neoplasm (HP:0011794)1.76681918
162Abnormality of the labia majora (HP:0012881)1.76659130
163Acute myeloid leukemia (HP:0004808)1.76538375
164Astigmatism (HP:0000483)1.76509419
165Tented upper lip vermilion (HP:0010804)1.76470778
166Adenoma sebaceum (HP:0009720)1.75679570
167Angiofibromas (HP:0010615)1.75679570
168Impulsivity (HP:0100710)1.75436965
169Muscle fibrillation (HP:0010546)1.75235511
170Decreased central vision (HP:0007663)1.74723460
171Intestinal atresia (HP:0011100)1.74593633
172Recurrent fungal infections (HP:0002841)1.73835850
173Myelodysplasia (HP:0002863)1.73587512
174Occipital encephalocele (HP:0002085)1.73079542
175Absent epiphyses (HP:0010577)1.71995317
176Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71995317
177Benign neoplasm of the central nervous system (HP:0100835)1.71221721
178Highly arched eyebrow (HP:0002553)1.71059821
179Cupped ear (HP:0000378)1.69982958
180Trigonocephaly (HP:0000243)1.69811483
181Chorioretinal atrophy (HP:0000533)1.69775873
182Neoplasm of the rectum (HP:0100743)1.69619883
183Sacral dimple (HP:0000960)1.69603238
184Absence seizures (HP:0002121)1.69601008
185Leukocytosis (HP:0001974)1.69551793
186Basal cell carcinoma (HP:0002671)1.69545912
187Pachygyria (HP:0001302)1.68582070
188Bowel diverticulosis (HP:0005222)1.68115573
189Abnormal number of erythroid precursors (HP:0012131)1.67857112
190Long clavicles (HP:0000890)1.67812952
191Neoplasm of the small intestine (HP:0100833)1.66153762
192Broad long bones (HP:0005622)1.65803766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.26364913
2EEF2K4.37550272
3CDC73.01253801
4BMPR1B2.90560562
5ERBB32.82480302
6PKN22.58502708
7CASK2.48753112
8MAP2K32.29921260
9MAP4K22.22905183
10SIK32.19934988
11ADRBK22.17972413
12DYRK1B2.17892079
13DYRK32.14366311
14PIM22.10997928
15SCYL22.10127179
16IRAK42.09923854
17MAP4K12.06723529
18WEE12.01791331
19ACVR1B2.00644849
20TAOK31.94870685
21NUAK11.84191093
22WNK31.79186257
23BRD41.79106625
24TNIK1.77317456
25MAP3K41.75428194
26ATR1.71374232
27FLT31.70153242
28BRSK21.65557004
29RPS6KB21.64045532
30TXK1.63624810
31PINK11.61267469
32GRK11.60346782
33BUB11.57451574
34INSRR1.57077446
35NTRK31.55735955
36STK38L1.53886245
37TTK1.52869246
38MKNK21.52776554
39STK241.51406512
40TRIM281.46898266
41PASK1.45218472
42AKT31.44000255
43CDK71.40758252
44PLK41.25257336
45ZAP701.25035415
46MAPK131.23082822
47RPS6KA41.20494165
48TSSK61.19785547
49OXSR11.17140359
50MAP3K101.16770424
51NEK21.16610120
52BTK1.16457943
53DAPK11.09630217
54TGFBR11.09317711
55ZAK1.07148306
56CHEK21.06569360
57ADRBK11.06141385
58MAPKAPK31.05974319
59CDK121.03895115
60PAK31.03536087
61RPS6KA21.02495374
62AURKB1.00752981
63PLK10.99682631
64BCR0.98534548
65SGK20.97407450
66GRK60.97348963
67FGFR20.96751269
68FER0.96709514
69LATS10.96102740
70MAP3K70.94967866
71TNK20.94073392
72DAPK20.93652513
73PRKCE0.89364519
74LRRK20.87399460
75RPS6KB10.86983126
76STK390.86594524
77NEK10.85755295
78CAMK1G0.84567830
79CDK40.83751997
80OBSCN0.82838989
81WNK40.81184205
82RPS6KL10.80344782
83RPS6KC10.80344782
84TTN0.79045429
85PNCK0.77990557
86TEC0.76308152
87SRPK10.75522120
88STK30.74968935
89CHEK10.74543750
90NEK90.74467406
91PAK40.74254522
92TRPM70.73486092
93MKNK10.73041990
94MAP3K60.71587412
95EPHA40.71394131
96CSNK1A1L0.71320858
97PLK30.70624959
98YES10.70267433
99CLK10.69611979
100NLK0.69043557
101PTK2B0.68751160
102UHMK10.68448160
103PRKCG0.67839712
104MARK10.67715107
105STK40.67611327
106MAP3K120.67457740
107SIK20.66787029
108RPS6KA60.65464267
109STK380.65319395
110PTK60.63805556
111PIK3CG0.62771123
112TYK20.62704096
113CDK60.62646734
114MAP3K140.61901199
115PIM10.61706603
116CAMK2A0.60561513
117SGK2230.60349014
118SGK4940.60349014
119MINK10.59632743
120CSNK1G20.59522676
121CDK20.59391333
122PRKAA20.58640108
123SYK0.57756183
124MAP2K70.57220147
125PKN10.56324676
126PAK20.55664908
127RAF10.55368387
128CSNK1G10.54645126
129MAP3K130.54636544
130MAP3K110.53303297
131CAMK40.53143015
132CDK10.52811811
133CAMK1D0.52764974
134MAPK110.52670594
135PIK3CA0.52287008
136AURKA0.51777297
137EPHA30.51301531
138ATM0.49532532
139PHKG10.49504087
140PHKG20.49504087
141CDK80.47682156
142PLK20.47311615
143CSF1R0.47208447
144STK110.46979818
145CCNB10.46335348
146PRKAA10.45814143
147DYRK20.45406635
148KSR10.45222266
149ERBB20.44626466
150ILK0.44042634
151CSNK1G30.43916688
152NTRK20.43417468
153KIT0.43363055
154CAMKK20.43357956
155EIF2AK30.42836725
156CAMK10.42657072
157CSNK1D0.42478574
158MAPK90.41961160
159CHUK0.40276305
160CDK30.39970075
161PRKACA0.38371604
162PRKG10.37489390
163SGK10.36596914
164MUSK0.36241842
165DYRK1A0.34003275
166ITK0.32724019
167CDK50.32274993
168MAP2K40.31385344
169GRK50.31294307
170PRKACB0.29749438
171PRKCH0.29655291
172CSNK1A10.29369942
173MAPKAPK50.27880049
174PRKCA0.26065728

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.00026367
2Mismatch repair_Homo sapiens_hsa034303.97597775
3Olfactory transduction_Homo sapiens_hsa047403.50729505
4Base excision repair_Homo sapiens_hsa034103.20873371
5Nicotine addiction_Homo sapiens_hsa050332.87124022
6Phototransduction_Homo sapiens_hsa047442.84983794
7Cell cycle_Homo sapiens_hsa041102.69529719
8Butanoate metabolism_Homo sapiens_hsa006502.57925587
9Non-homologous end-joining_Homo sapiens_hsa034502.45573400
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40297453
11ABC transporters_Homo sapiens_hsa020102.33096860
12RNA degradation_Homo sapiens_hsa030182.31386895
13Homologous recombination_Homo sapiens_hsa034402.29889702
14RNA transport_Homo sapiens_hsa030132.16027857
15Linoleic acid metabolism_Homo sapiens_hsa005912.13598296
16RNA polymerase_Homo sapiens_hsa030202.08927754
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06790555
18Antigen processing and presentation_Homo sapiens_hsa046122.06646568
19Spliceosome_Homo sapiens_hsa030402.06630815
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.02188791
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99492388
22Taste transduction_Homo sapiens_hsa047421.95510272
23Nitrogen metabolism_Homo sapiens_hsa009101.91921927
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91400488
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.89969652
26Ribosome_Homo sapiens_hsa030101.88769817
27One carbon pool by folate_Homo sapiens_hsa006701.87924695
28Morphine addiction_Homo sapiens_hsa050321.85889431
29mRNA surveillance pathway_Homo sapiens_hsa030151.84933501
30Tryptophan metabolism_Homo sapiens_hsa003801.81706822
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77595582
32Circadian entrainment_Homo sapiens_hsa047131.73585309
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72431906
34Ether lipid metabolism_Homo sapiens_hsa005651.71066048
35Primary immunodeficiency_Homo sapiens_hsa053401.68739870
36Glutamatergic synapse_Homo sapiens_hsa047241.66683110
37Pyrimidine metabolism_Homo sapiens_hsa002401.66343581
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65904024
39Nucleotide excision repair_Homo sapiens_hsa034201.65190165
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.64098965
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63611516
42Histidine metabolism_Homo sapiens_hsa003401.59424957
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57965173
44Fanconi anemia pathway_Homo sapiens_hsa034601.53107197
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50594778
46GABAergic synapse_Homo sapiens_hsa047271.45673717
47Insulin secretion_Homo sapiens_hsa049111.44087319
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44086131
49Purine metabolism_Homo sapiens_hsa002301.43769686
50Colorectal cancer_Homo sapiens_hsa052101.42807667
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.42524958
52Salivary secretion_Homo sapiens_hsa049701.41761670
53Serotonergic synapse_Homo sapiens_hsa047261.40738439
54Propanoate metabolism_Homo sapiens_hsa006401.40650517
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40035238
56Thyroid cancer_Homo sapiens_hsa052161.39195564
57Calcium signaling pathway_Homo sapiens_hsa040201.32434504
58Chronic myeloid leukemia_Homo sapiens_hsa052201.26355671
59Proteasome_Homo sapiens_hsa030501.23118703
60Oocyte meiosis_Homo sapiens_hsa041141.22377501
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.20376419
62Caffeine metabolism_Homo sapiens_hsa002321.19512187
63Viral carcinogenesis_Homo sapiens_hsa052031.17357012
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.16534283
65Regulation of autophagy_Homo sapiens_hsa041401.16091065
66Dorso-ventral axis formation_Homo sapiens_hsa043201.15844311
67Epstein-Barr virus infection_Homo sapiens_hsa051691.14749534
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14151577
69Chemical carcinogenesis_Homo sapiens_hsa052041.13285945
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12942909
71Endometrial cancer_Homo sapiens_hsa052131.12400859
72Glycerolipid metabolism_Homo sapiens_hsa005611.11687180
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11276109
74HTLV-I infection_Homo sapiens_hsa051661.10649471
75Long-term depression_Homo sapiens_hsa047301.10380363
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09841113
77Retinol metabolism_Homo sapiens_hsa008301.08741671
78Shigellosis_Homo sapiens_hsa051311.08496627
79B cell receptor signaling pathway_Homo sapiens_hsa046621.08194276
80Dopaminergic synapse_Homo sapiens_hsa047281.07521906
81Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04604161
82Vascular smooth muscle contraction_Homo sapiens_hsa042701.04437313
83Ovarian steroidogenesis_Homo sapiens_hsa049131.02144529
84p53 signaling pathway_Homo sapiens_hsa041151.01880711
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01045774
86Circadian rhythm_Homo sapiens_hsa047101.01030205
87MicroRNAs in cancer_Homo sapiens_hsa052061.00225041
88Protein export_Homo sapiens_hsa030601.00021853
89Renin secretion_Homo sapiens_hsa049240.99836220
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96138826
91cAMP signaling pathway_Homo sapiens_hsa040240.95181452
92Cholinergic synapse_Homo sapiens_hsa047250.94863262
93Lysine degradation_Homo sapiens_hsa003100.94844061
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94493498
95Small cell lung cancer_Homo sapiens_hsa052220.93488667
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93423986
97Apoptosis_Homo sapiens_hsa042100.91701494
98Non-small cell lung cancer_Homo sapiens_hsa052230.89630032
99Alcoholism_Homo sapiens_hsa050340.88891869
100Oxytocin signaling pathway_Homo sapiens_hsa049210.87204685
101Gastric acid secretion_Homo sapiens_hsa049710.86535030
102Acute myeloid leukemia_Homo sapiens_hsa052210.85695853
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84723553
104Systemic lupus erythematosus_Homo sapiens_hsa053220.83994287
105beta-Alanine metabolism_Homo sapiens_hsa004100.81457160
106Hepatitis B_Homo sapiens_hsa051610.81301782
107Notch signaling pathway_Homo sapiens_hsa043300.80708984
108Arachidonic acid metabolism_Homo sapiens_hsa005900.79250172
109Asthma_Homo sapiens_hsa053100.79018009
110Herpes simplex infection_Homo sapiens_hsa051680.78197513
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.78180719
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77480240
113Amphetamine addiction_Homo sapiens_hsa050310.77478582
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.77419680
115T cell receptor signaling pathway_Homo sapiens_hsa046600.76826755
116Renin-angiotensin system_Homo sapiens_hsa046140.76485359
117Peroxisome_Homo sapiens_hsa041460.76096729
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75799694
119Type II diabetes mellitus_Homo sapiens_hsa049300.75169830
120N-Glycan biosynthesis_Homo sapiens_hsa005100.74081939
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73559295
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.73537582
123Pancreatic cancer_Homo sapiens_hsa052120.72988047
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72339316
125Cocaine addiction_Homo sapiens_hsa050300.72185299
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71656210
127Pancreatic secretion_Homo sapiens_hsa049720.71131394
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68440222
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.67130220
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66581847
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66206294
132Selenocompound metabolism_Homo sapiens_hsa004500.65093533
133Fatty acid biosynthesis_Homo sapiens_hsa000610.62924779
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62101163
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60306538
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57425648
137Fatty acid degradation_Homo sapiens_hsa000710.57384915
138Platelet activation_Homo sapiens_hsa046110.57328058
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57192005
140Glioma_Homo sapiens_hsa052140.56624612
141Sphingolipid metabolism_Homo sapiens_hsa006000.51938414
142Viral myocarditis_Homo sapiens_hsa054160.51480963
143Adherens junction_Homo sapiens_hsa045200.51464197
144Pathways in cancer_Homo sapiens_hsa052000.50587071
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50166586
146Bladder cancer_Homo sapiens_hsa052190.47709929
147Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46284740
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45588233
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45361446
150Fatty acid metabolism_Homo sapiens_hsa012120.45302097
151Estrogen signaling pathway_Homo sapiens_hsa049150.44070487
152Axon guidance_Homo sapiens_hsa043600.43062380
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.42151936
154Toxoplasmosis_Homo sapiens_hsa051450.41020130
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40789059
156Legionellosis_Homo sapiens_hsa051340.40327059
157Measles_Homo sapiens_hsa051620.39971643
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38756875
159Ras signaling pathway_Homo sapiens_hsa040140.38524160
160Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37384779
161Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37026264
162Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36422834
163Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35363637
164Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34862914
165Proteoglycans in cancer_Homo sapiens_hsa052050.34731783
166Basal transcription factors_Homo sapiens_hsa030220.34537279
167Prostate cancer_Homo sapiens_hsa052150.34191551
168FoxO signaling pathway_Homo sapiens_hsa040680.34017798
169Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33484497
170Influenza A_Homo sapiens_hsa051640.33319137
171Salmonella infection_Homo sapiens_hsa051320.31484823
172Pentose phosphate pathway_Homo sapiens_hsa000300.30886990
173Bile secretion_Homo sapiens_hsa049760.30659775
174Vibrio cholerae infection_Homo sapiens_hsa051100.30520544
175Hematopoietic cell lineage_Homo sapiens_hsa046400.30465827
176Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30127730
177Dilated cardiomyopathy_Homo sapiens_hsa054140.30044672
178Insulin signaling pathway_Homo sapiens_hsa049100.30009438
179Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29290373
180Hepatitis C_Homo sapiens_hsa051600.29218754
181Hedgehog signaling pathway_Homo sapiens_hsa043400.28225469
182Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28217607
183Tuberculosis_Homo sapiens_hsa051520.28072873
184Leishmaniasis_Homo sapiens_hsa051400.27567411
185Fat digestion and absorption_Homo sapiens_hsa049750.27038338
186Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25694246
1872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23530528
188AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21693197

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