ZSCAN29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.37253993
2positive regulation of gamma-delta T cell activation (GO:0046645)4.88049992
3negative regulation of translation, ncRNA-mediated (GO:0040033)4.53719770
4regulation of translation, ncRNA-mediated (GO:0045974)4.53719770
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.53719770
6regulation of gene silencing by RNA (GO:0060966)4.23263202
7regulation of posttranscriptional gene silencing (GO:0060147)4.23263202
8regulation of gene silencing by miRNA (GO:0060964)4.23263202
9negative regulation of histone methylation (GO:0031061)4.17930711
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00078905
11regulation of histone H3-K9 methylation (GO:0051570)3.94074387
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.89512395
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89512395
14nuclear pore organization (GO:0006999)3.87872847
15leukocyte aggregation (GO:0070486)3.84103644
16heterochromatin organization (GO:0070828)3.71949448
17regulation of RIG-I signaling pathway (GO:0039535)3.66475958
18antigen processing and presentation of endogenous antigen (GO:0019883)3.65659106
19histone H3-K4 trimethylation (GO:0080182)3.63131274
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.63068399
21regulation of gamma-delta T cell activation (GO:0046643)3.60146550
22regulation of gamma-delta T cell differentiation (GO:0045586)3.57136835
23positive regulation of histone H3-K4 methylation (GO:0051571)3.52510213
24regulation of DNA methylation (GO:0044030)3.48246746
25single strand break repair (GO:0000012)3.44106892
26cytoplasmic mRNA processing body assembly (GO:0033962)3.41136094
27negative regulation of phagocytosis (GO:0050765)3.38190162
28positive regulation of B cell differentiation (GO:0045579)3.34105152
29snRNA transcription (GO:0009301)3.24252964
30positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.21731565
31chromatin silencing (GO:0006342)3.16873465
32peptidyl-lysine trimethylation (GO:0018023)3.11692051
33monoubiquitinated protein deubiquitination (GO:0035520)3.11526295
34histone H3-K9 methylation (GO:0051567)3.11030129
35histone H2B ubiquitination (GO:0033523)3.10511431
36regulation of B cell receptor signaling pathway (GO:0050855)3.10023856
37behavioral response to nicotine (GO:0035095)3.08387013
38meiotic chromosome segregation (GO:0045132)3.07703262
39positive regulation of developmental pigmentation (GO:0048087)3.07115932
40chromatin assembly (GO:0031497)3.03885114
41paraxial mesoderm development (GO:0048339)3.03670918
42NIK/NF-kappaB signaling (GO:0038061)3.03336633
43regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.03113462
44regulation of histone methylation (GO:0031060)3.03022048
45regulation of RNA export from nucleus (GO:0046831)3.01632423
46regulation of histone H3-K4 methylation (GO:0051569)3.01525750
47modulation by symbiont of host defense response (GO:0052031)2.99770438
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99770438
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99770438
50positive regulation by organism of defense response of other organism involved in symbiotic interact2.99770438
51modulation by symbiont of host immune response (GO:0052553)2.99770438
52positive regulation by symbiont of host defense response (GO:0052509)2.99770438
53centriole replication (GO:0007099)2.97680580
54negative regulation of gene expression, epigenetic (GO:0045814)2.97553153
55regulation of chromatin binding (GO:0035561)2.96832464
56negative T cell selection (GO:0043383)2.95002569
57somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94141677
58somatic hypermutation of immunoglobulin genes (GO:0016446)2.94141677
59positive regulation of histone methylation (GO:0031062)2.93502444
60regulation of B cell differentiation (GO:0045577)2.91990355
61negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.91431351
62positive regulation of interferon-alpha production (GO:0032727)2.91181541
63substrate-independent telencephalic tangential migration (GO:0021826)2.90078742
64substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.90078742
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89510460
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88562517
67negative thymic T cell selection (GO:0045060)2.85464577
68neutrophil activation involved in immune response (GO:0002283)2.85407362
69DNA topological change (GO:0006265)2.84672235
70ncRNA catabolic process (GO:0034661)2.83214796
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82281864
72DNA methylation (GO:0006306)2.82207728
73DNA alkylation (GO:0006305)2.82207728
74DNA replication checkpoint (GO:0000076)2.80016237
75definitive hemopoiesis (GO:0060216)2.79659135
76regulation of interferon-alpha production (GO:0032647)2.78187037
77positive thymic T cell selection (GO:0045059)2.76701076
78response to peptidoglycan (GO:0032494)2.75416264
79regulation of centriole replication (GO:0046599)2.75261113
80histone H3-K36 demethylation (GO:0070544)2.75010360
81positive regulation of gene expression, epigenetic (GO:0045815)2.74667515
82response to type I interferon (GO:0034340)2.73393154
83DNA damage induced protein phosphorylation (GO:0006975)2.68541938
84positive regulation of isotype switching (GO:0045830)2.68496740
85neuronal stem cell maintenance (GO:0097150)2.68312571
86positive regulation by host of viral transcription (GO:0043923)2.68121854
87regulation of centrosome duplication (GO:0010824)2.67579396
88regulation of gene silencing (GO:0060968)2.67500811
89type I interferon signaling pathway (GO:0060337)2.67411406
90cellular response to type I interferon (GO:0071357)2.67411406
91peptidyl-lysine methylation (GO:0018022)2.66271805
92histone H3-K9 modification (GO:0061647)2.65905234
93immunoglobulin mediated immune response (GO:0016064)2.64642546
94kidney morphogenesis (GO:0060993)2.64379317
95ATP-dependent chromatin remodeling (GO:0043044)2.64369880
96programmed necrotic cell death (GO:0097300)2.63918750
97regulation of growth hormone secretion (GO:0060123)2.63862320
98nonmotile primary cilium assembly (GO:0035058)2.63535277
99regulation of centrosome cycle (GO:0046605)2.62841897
100regulation of interferon-beta biosynthetic process (GO:0045357)2.62564143
101necrotic cell death (GO:0070265)2.60604354
102V(D)J recombination (GO:0033151)2.60307754
103chromatin remodeling at centromere (GO:0031055)2.59832609
104cell proliferation in forebrain (GO:0021846)2.59661411
105negative regulation of chromatin modification (GO:1903309)2.58530176
106tolerance induction (GO:0002507)2.57440323
107mitotic sister chromatid cohesion (GO:0007064)2.57223487
108presynaptic membrane organization (GO:0097090)2.55352457
109organ growth (GO:0035265)2.55194637
110regulation of nuclear cell cycle DNA replication (GO:0033262)2.55045299
111genetic imprinting (GO:0071514)2.54561326
112determination of adult lifespan (GO:0008340)2.53702564
113negative regulation of cell cycle G2/M phase transition (GO:1902750)2.53633039
114cellular response to zinc ion (GO:0071294)2.52501498
115negative regulation of histone modification (GO:0031057)2.51789800
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50409724
117regulation of gene expression by genetic imprinting (GO:0006349)2.50373064
118histone monoubiquitination (GO:0010390)2.49410010
119interferon-gamma production (GO:0032609)2.49203379
120dorsal/ventral axis specification (GO:0009950)2.48087265
121neutrophil activation (GO:0042119)2.47956421
122negative regulation of DNA-dependent DNA replication (GO:2000104)2.46944573
123actin nucleation (GO:0045010)2.46512735
124T cell selection (GO:0045058)2.46343996
125protein prenylation (GO:0018342)2.45548796
126prenylation (GO:0097354)2.45548796
127forebrain neuron differentiation (GO:0021879)2.45404816
128neural tube formation (GO:0001841)2.45179830
129tongue development (GO:0043586)2.44721373
130regulation of helicase activity (GO:0051095)2.44343843
131positive T cell selection (GO:0043368)2.44033706
132regulation of stem cell maintenance (GO:2000036)2.43959025
133neutrophil mediated immunity (GO:0002446)2.43391935
134regulation of pigment cell differentiation (GO:0050932)2.43359451
135head development (GO:0060322)2.43285309
136hindbrain development (GO:0030902)2.43251956
137positive regulation of DNA recombination (GO:0045911)2.42542921
138positive regulation of natural killer cell differentiation (GO:0032825)2.42324707
139necroptotic process (GO:0070266)2.42135444
140spinal cord development (GO:0021510)2.41935868
141hepatocyte apoptotic process (GO:0097284)2.41325361
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.41246429
143detection of molecule of bacterial origin (GO:0032490)2.39603314
144response to interleukin-15 (GO:0070672)2.39077708
145response to muramyl dipeptide (GO:0032495)2.39067906
146cellular extravasation (GO:0045123)2.38621828
147protein localization to chromosome, centromeric region (GO:0071459)2.38112290
148protein localization to kinetochore (GO:0034501)2.38100764
149reciprocal meiotic recombination (GO:0007131)2.37256172
150reciprocal DNA recombination (GO:0035825)2.37256172
151negative regulation of granulocyte differentiation (GO:0030853)2.36902307
152CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.36703571
153negative regulation of smooth muscle cell differentiation (GO:0051151)2.35718593
154respiratory burst (GO:0045730)2.35504840
155protein-DNA complex disassembly (GO:0032986)2.35306716
156nucleosome disassembly (GO:0006337)2.35306716
157histone-serine phosphorylation (GO:0035404)2.34751628
158thymic T cell selection (GO:0045061)2.34555582
159CENP-A containing nucleosome assembly (GO:0034080)2.34516035
160dendritic cell chemotaxis (GO:0002407)2.34139341
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.33134068
162granulocyte activation (GO:0036230)2.31075571
163regulation of necroptotic process (GO:0060544)2.30813791
164dendritic cell migration (GO:0036336)2.30350174
165T cell lineage commitment (GO:0002360)2.27691208
166cellular response to virus (GO:0098586)2.27432093
167myeloid dendritic cell activation (GO:0001773)2.26175305
168regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.25370827
169leukocyte cell-cell adhesion (GO:0007159)2.24353031
170T-helper cell differentiation (GO:0042093)2.22420103
171CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.22420103
172positive regulation of humoral immune response (GO:0002922)2.22331940
173interferon-gamma-mediated signaling pathway (GO:0060333)2.22023227
174T cell migration (GO:0072678)2.21666769
175B cell homeostasis (GO:0001782)2.21304662
176regulation of DNA endoreduplication (GO:0032875)2.20199518
177regulation of T cell receptor signaling pathway (GO:0050856)2.19996015
178positive regulation of B cell mediated immunity (GO:0002714)2.18758246
179positive regulation of immunoglobulin mediated immune response (GO:0002891)2.18758246
180daunorubicin metabolic process (GO:0044597)2.18594359
181polyketide metabolic process (GO:0030638)2.18594359
182doxorubicin metabolic process (GO:0044598)2.18594359
183defense response to protozoan (GO:0042832)2.18293284
184positive regulation of antigen processing and presentation (GO:0002579)2.18210124
185regulation of response to interferon-gamma (GO:0060330)2.17597532
186regulation of alpha-beta T cell proliferation (GO:0046640)2.17344283
187positive regulation of interferon-beta production (GO:0032728)2.17296628
188cellular response to interleukin-15 (GO:0071350)2.15793323
189negative regulation of B cell proliferation (GO:0030889)2.15055043
190lymphocyte homeostasis (GO:0002260)2.14775480
191T cell homeostasis (GO:0043029)2.14632112
192nuclear pore complex assembly (GO:0051292)2.14512586
193regulation of interleukin-2 biosynthetic process (GO:0045076)2.13403089
194pore complex assembly (GO:0046931)2.13338351
195B cell mediated immunity (GO:0019724)2.12228204
196positive regulation of B cell activation (GO:0050871)2.11416674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.23209603
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.77248065
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.73080213
4EZH2_22144423_ChIP-Seq_EOC_Human4.40251165
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.83376972
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.73062486
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72463186
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.61646626
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.40418834
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.35207808
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.26048149
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88148966
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63841606
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.57923524
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56969462
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.54456530
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43872242
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40141023
19FUS_26573619_Chip-Seq_HEK293_Human2.37617384
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.32660234
21EWS_26573619_Chip-Seq_HEK293_Human2.31612887
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29305806
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28668410
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24944667
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.23205452
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21544128
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20711382
28EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15664828
29SCL_19346495_ChIP-Seq_HPC-7_Human2.12546024
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11794015
31RUNX_20019798_ChIP-Seq_JUKART_Human2.11442989
32GATA1_22025678_ChIP-Seq_K562_Human2.10618842
33BP1_19119308_ChIP-ChIP_Hs578T_Human2.07262220
34ZNF274_21170338_ChIP-Seq_K562_Hela2.02223387
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00068241
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.99905478
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99905478
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97118138
39MYB_26560356_Chip-Seq_TH2_Human1.97087372
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94374117
41MYB_26560356_Chip-Seq_TH1_Human1.92387004
42IRF1_19129219_ChIP-ChIP_H3396_Human1.88298345
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86963907
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86564118
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84001834
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80720206
47SPI1_23547873_ChIP-Seq_NB4_Human1.79624536
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76233144
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72439612
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70928742
51GBX2_23144817_ChIP-Seq_PC3_Human1.70250568
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.65682074
53MYC_22102868_ChIP-Seq_BL_Human1.64118023
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62988174
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.61748175
56IGF1R_20145208_ChIP-Seq_DFB_Human1.61084736
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57888025
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57799293
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53086543
60PU_27001747_Chip-Seq_BMDM_Mouse1.51965908
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.48220837
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.46987723
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46509709
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44789201
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42633422
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41063680
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41043984
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.40819401
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40046290
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39934380
71P300_19829295_ChIP-Seq_ESCs_Human1.39869922
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38759457
73TAF15_26573619_Chip-Seq_HEK293_Human1.38604108
74MYC_18940864_ChIP-ChIP_HL60_Human1.37845294
75MAF_26560356_Chip-Seq_TH1_Human1.36620837
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36208851
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.34645355
78VDR_24763502_ChIP-Seq_THP-1_Human1.34397803
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33788316
80FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33657229
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33483772
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32284568
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.31015104
84STAT3_23295773_ChIP-Seq_U87_Human1.30550359
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30087909
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27921477
87ER_23166858_ChIP-Seq_MCF-7_Human1.26634678
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26083427
89* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25992525
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.25349138
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25329358
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.24743973
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24598555
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.24036186
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23571401
96UTX_26944678_Chip-Seq_JUKART_Human1.23413571
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22975357
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22168024
99ELK1_19687146_ChIP-ChIP_HELA_Human1.20690370
100GATA3_27048872_Chip-Seq_THYMUS_Human1.20464467
101VDR_24787735_ChIP-Seq_THP-1_Human1.20448655
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18999550
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18787091
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18404284
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17734158
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17371234
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15610842
108RNF2_27304074_Chip-Seq_NSC_Mouse1.14758002
109* TCF4_23295773_ChIP-Seq_U87_Human1.13214302
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12265921
111GATA3_26560356_Chip-Seq_TH2_Human1.11593185
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11486206
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11237195
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11040369
115RXR_22158963_ChIP-Seq_LIVER_Mouse1.10170189
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09621838
117VDR_21846776_ChIP-Seq_THP-1_Human1.09168539
118ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09090931
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08626035
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08341569
121CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07697019
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07337478
123TCF7_22412390_ChIP-Seq_EML_Mouse1.07310384
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07265226
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06700661
126TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05713810
127PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04427838
128WDR5_24793694_ChIP-Seq_LNCAP_Human1.04373107
129TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03993488
130ISL1_27105846_Chip-Seq_CPCs_Mouse1.02173620
131TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00630371
132LXR_22158963_ChIP-Seq_LIVER_Mouse1.00580606
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00184658
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99682329
135CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98749473
136AR_21572438_ChIP-Seq_LNCaP_Human0.98306587
137HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98287194
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98123847
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97524193
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.97511623
141CBP_20019798_ChIP-Seq_JUKART_Human0.97250301
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97250301
143BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96810617
144REST_21632747_ChIP-Seq_MESCs_Mouse0.96712897
145SPI1_23127762_ChIP-Seq_K562_Human0.96702463
146SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96477419
147CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96271612
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95480399
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.95122122
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.95027331
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95010713
152POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94478827
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93625700
154AR_19668381_ChIP-Seq_PC3_Human0.93587577
155RUNX2_22187159_ChIP-Seq_PCA_Human0.92874650
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92833944
157DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91111943
158SMAD3_21741376_ChIP-Seq_ESCs_Human0.90403843
159GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90372101
160PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90298113
161TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90272509
162PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89938973
163SMAD4_21799915_ChIP-Seq_A2780_Human0.89535202
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88789790
165TFEB_21752829_ChIP-Seq_HELA_Human0.88539076
166CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88232782
167GF1B_26923725_Chip-Seq_HPCs_Mouse0.88040804
168VDR_22108803_ChIP-Seq_LS180_Human0.87448902
169GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87247544
170TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86558045
171TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86540591
172PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86425799
173AR_21909140_ChIP-Seq_LNCAP_Human0.85198128
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84621010
175CIITA_25753668_ChIP-Seq_RAJI_Human0.84050708
176NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83744860
177PIAS1_25552417_ChIP-Seq_VCAP_Human0.83016529
178FOXP3_21729870_ChIP-Seq_TREG_Human0.82929014
179SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82803655
180SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82320196
181KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81943058
182EZH2_27294783_Chip-Seq_NPCs_Mouse0.81020607
183E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80922325
184VDR_23849224_ChIP-Seq_CD4+_Human0.80612830
185PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80539785
186FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79630379
187CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77907407
188CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77672141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry4.04130741
2MP0003136_yellow_coat_color3.42935477
3MP0001835_abnormal_antigen_presentation3.21402571
4MP0006292_abnormal_olfactory_placode3.16552523
5MP0008877_abnormal_DNA_methylation2.71356945
6MP0002396_abnormal_hematopoietic_system2.63994760
7MP0003763_abnormal_thymus_physiology2.60645466
8MP0005671_abnormal_response_to2.36833052
9MP0001800_abnormal_humoral_immune2.30733606
10MP0009785_altered_susceptibility_to2.29889014
11MP0003119_abnormal_digestive_system2.25326100
12MP0003436_decreased_susceptibility_to2.17033174
13MP0003121_genomic_imprinting2.15477902
14MP0001790_abnormal_immune_system2.13122813
15MP0005387_immune_system_phenotype2.13122813
16MP0002452_abnormal_antigen_presenting2.04567035
17MP0001293_anophthalmia2.04341878
18MP0002419_abnormal_innate_immunity2.00394870
19MP0005000_abnormal_immune_tolerance1.99293965
20MP0002723_abnormal_immune_serum1.96878901
21MP0002166_altered_tumor_susceptibility1.95889820
22MP0005025_abnormal_response_to1.93711655
23MP0002420_abnormal_adaptive_immunity1.91722891
24MP0003937_abnormal_limbs/digits/tail_de1.90956560
25MP0001819_abnormal_immune_cell1.90756396
26MP0005360_urolithiasis1.90752383
27MP0000569_abnormal_digit_pigmentation1.90513818
28MP0005365_abnormal_bile_salt1.82541847
29MP0002653_abnormal_ependyma_morphology1.82422357
30MP0002398_abnormal_bone_marrow1.81361093
31MP0003300_gastrointestinal_ulcer1.81290094
32MP0000778_abnormal_nervous_system1.80090401
33MP0002148_abnormal_hypersensitivity_rea1.79917647
34MP0004957_abnormal_blastocyst_morpholog1.78121209
35MP0003123_paternal_imprinting1.76274956
36MP0004808_abnormal_hematopoietic_stem1.75480696
37MP0003122_maternal_imprinting1.71351821
38MP0002006_tumorigenesis1.69474281
39MP0000685_abnormal_immune_system1.69169464
40MP0010155_abnormal_intestine_physiology1.67252660
41MP0000716_abnormal_immune_system1.65122749
42MP0002405_respiratory_system_inflammati1.64790956
43MP0009379_abnormal_foot_pigmentation1.61711846
44MP0000631_abnormal_neuroendocrine_gland1.61346206
45MP0001873_stomach_inflammation1.60114551
46MP0003724_increased_susceptibility_to1.59335190
47MP0002084_abnormal_developmental_patter1.56679860
48MP0001845_abnormal_inflammatory_respons1.54499482
49MP0004782_abnormal_surfactant_physiolog1.54039999
50MP0005464_abnormal_platelet_physiology1.52445103
51MP0005394_taste/olfaction_phenotype1.51832033
52MP0005499_abnormal_olfactory_system1.51832033
53MP0001545_abnormal_hematopoietic_system1.51032450
54MP0005397_hematopoietic_system_phenotyp1.51032450
55MP0003567_abnormal_fetal_cardiomyocyte1.49934165
56MP0009333_abnormal_splenocyte_physiolog1.49212501
57MP0000689_abnormal_spleen_morphology1.48865572
58MP0002132_abnormal_respiratory_system1.46035180
59MP0000427_abnormal_hair_cycle1.44470574
60MP0003646_muscle_fatigue1.43501901
61MP0006082_CNS_inflammation1.43491420
62MP0001286_abnormal_eye_development1.43316366
63MP0004947_skin_inflammation1.43104922
64MP0003252_abnormal_bile_duct1.42685118
65MP0010094_abnormal_chromosome_stability1.42266807
66MP0001853_heart_inflammation1.41672464
67MP0000490_abnormal_crypts_of1.41355568
68MP0002697_abnormal_eye_size1.40843816
69MP0002429_abnormal_blood_cell1.40415424
70MP0003693_abnormal_embryo_hatching1.39307490
71MP0002722_abnormal_immune_system1.37841911
72MP0006276_abnormal_autonomic_nervous1.36992538
73MP0003861_abnormal_nervous_system1.35627193
74MP0008057_abnormal_DNA_replication1.35551052
75MP0004197_abnormal_fetal_growth/weight/1.35139130
76MP0001986_abnormal_taste_sensitivity1.33336093
77MP0008789_abnormal_olfactory_epithelium1.31682464
78MP0008058_abnormal_DNA_repair1.31352026
79MP0003718_maternal_effect1.31133066
80MP0001672_abnormal_embryogenesis/_devel1.29887086
81MP0005380_embryogenesis_phenotype1.29887086
82MP0008932_abnormal_embryonic_tissue1.29278234
83MP0008469_abnormal_protein_level1.28811998
84MP0000383_abnormal_hair_follicle1.26660614
85MP0009672_abnormal_birth_weight1.26355052
86MP0002085_abnormal_embryonic_tissue1.25813173
87MP0001764_abnormal_homeostasis1.25428287
88MP0000703_abnormal_thymus_morphology1.24745950
89MP0003303_peritoneal_inflammation1.24692465
90MP0002233_abnormal_nose_morphology1.23380825
91MP0005409_darkened_coat_color1.21476487
92MP0001188_hyperpigmentation1.20870715
93MP0003984_embryonic_growth_retardation1.20794230
94MP0002139_abnormal_hepatobiliary_system1.20583281
95MP0002088_abnormal_embryonic_growth/wei1.19564156
96MP0002092_abnormal_eye_morphology1.16749005
97MP0001697_abnormal_embryo_size1.15235969
98MP0009764_decreased_sensitivity_to1.14619582
99MP0001730_embryonic_growth_arrest1.13918848
100MP0003943_abnormal_hepatobiliary_system1.13695344
101MP0008961_abnormal_basal_metabolism1.13403118
102MP0002751_abnormal_autonomic_nervous1.12279752
103MP0001851_eye_inflammation1.12076780
104MP0000858_altered_metastatic_potential1.11249695
105MP0009697_abnormal_copulation1.09697252
106MP0003935_abnormal_craniofacial_develop1.09433419
107MP0005310_abnormal_salivary_gland1.09292278
108MP0000428_abnormal_craniofacial_morphol1.08975438
109MP0003941_abnormal_skin_development1.08088498
110MP0004133_heterotaxia1.07516374
111MP0005174_abnormal_tail_pigmentation1.07397086
112MP0010678_abnormal_skin_adnexa1.06778423
113MP0005085_abnormal_gallbladder_physiolo1.06531358
114MP0008995_early_reproductive_senescence1.03147696
115MP0003183_abnormal_peptide_metabolism1.01812095
116MP0002138_abnormal_hepatobiliary_system1.01565827
117MP0001533_abnormal_skeleton_physiology1.01006128
118MP0005187_abnormal_penis_morphology1.00916982
119MP0003938_abnormal_ear_development0.98932247
120MP0002160_abnormal_reproductive_system0.98559888
121MP0003011_delayed_dark_adaptation0.98444548
122MP0003755_abnormal_palate_morphology0.98337680
123MP0009703_decreased_birth_body0.97488393
124MP0002938_white_spotting0.96792982
125MP0009763_increased_sensitivity_to0.96181520
126MP0008007_abnormal_cellular_replicative0.95651063
127MP0002009_preneoplasia0.95596463
128MP0000465_gastrointestinal_hemorrhage0.95177369
129MP0003115_abnormal_respiratory_system0.94776583
130MP0002111_abnormal_tail_morphology0.94741920
131MP0000350_abnormal_cell_proliferation0.94305812
132MP0002210_abnormal_sex_determination0.93805201
133MP0006072_abnormal_retinal_apoptosis0.92838870
134MP0003942_abnormal_urinary_system0.92692374
135MP0002909_abnormal_adrenal_gland0.91955284
136MP0006054_spinal_hemorrhage0.91421496
137MP0000015_abnormal_ear_pigmentation0.90820481
138MP0005391_vision/eye_phenotype0.90377439
139MP0000609_abnormal_liver_physiology0.89852953
140MP0002277_abnormal_respiratory_mucosa0.89737427
141MP0002019_abnormal_tumor_incidence0.88389884
142MP0001666_abnormal_nutrient_absorption0.88198863
143MP0003077_abnormal_cell_cycle0.87937482
144MP0005389_reproductive_system_phenotype0.87358724
145MP0001929_abnormal_gametogenesis0.86473577
146MP0002081_perinatal_lethality0.85895341
147MP0003950_abnormal_plasma_membrane0.85251362
148MP0010352_gastrointestinal_tract_polyps0.85136922
149MP0002152_abnormal_brain_morphology0.84521111
150MP0003656_abnormal_erythrocyte_physiolo0.83835745
151MP0003448_altered_tumor_morphology0.83818401
152MP0001324_abnormal_eye_pigmentation0.82688905
153MP0002089_abnormal_postnatal_growth/wei0.81408703
154MP0010307_abnormal_tumor_latency0.81286630
155MP0005408_hypopigmentation0.80938809
156MP0002075_abnormal_coat/hair_pigmentati0.79492860
157MP0002928_abnormal_bile_duct0.79392429
158MP0001919_abnormal_reproductive_system0.79003253
159MP0003385_abnormal_body_wall0.78847230
160MP0000955_abnormal_spinal_cord0.78015330
161MP0005220_abnormal_exocrine_pancreas0.77853172
162MP0000432_abnormal_head_morphology0.77029507
163MP0000647_abnormal_sebaceous_gland0.76683854
164MP0003111_abnormal_nucleus_morphology0.76625393
165MP0002998_abnormal_bone_remodeling0.76581915
166MP0002184_abnormal_innervation0.76028639
167MP0002234_abnormal_pharynx_morphology0.75778269
168MP0000579_abnormal_nail_morphology0.75140651
169MP0002752_abnormal_somatic_nervous0.75104649
170MP0009278_abnormal_bone_marrow0.75098015
171MP0003191_abnormal_cellular_cholesterol0.74714339
172MP0003787_abnormal_imprinting0.74463995
173MP0003315_abnormal_perineum_morphology0.74098252
174MP0002086_abnormal_extraembryonic_tissu0.74046684
175MP0000566_synostosis0.73806217
176MP0005195_abnormal_posterior_eye0.73467990
177MP0008875_abnormal_xenobiotic_pharmacok0.72531253
178MP0003866_abnormal_defecation0.70743650
179MP0001915_intracranial_hemorrhage0.70184687
180MP0000598_abnormal_liver_morphology0.69551138
181MP0002136_abnormal_kidney_physiology0.68416716
182MP0002095_abnormal_skin_pigmentation0.67799629
183MP0009765_abnormal_xenobiotic_induced0.67596868

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.41837778
2Abnormality of the fingertips (HP:0001211)4.10578062
3Eczematoid dermatitis (HP:0000976)4.02515926
4Recurrent abscess formation (HP:0002722)3.87949222
5Colon cancer (HP:0003003)3.71299527
6Recurrent bacterial skin infections (HP:0005406)3.53841659
7Recurrent gram-negative bacterial infections (HP:0005420)3.43549109
8Autoimmune thrombocytopenia (HP:0001973)3.38528347
9Pigmentary retinal degeneration (HP:0001146)3.32386240
10Neoplasm of the adrenal cortex (HP:0100641)3.31916336
11Recurrent fungal infections (HP:0002841)3.28918097
12IgM deficiency (HP:0002850)3.26430463
13Recurrent viral infections (HP:0004429)3.21484312
14Congenital stationary night blindness (HP:0007642)3.14362237
15T lymphocytopenia (HP:0005403)3.11573797
16Abnormality of T cell number (HP:0011839)3.04798406
17Chromsome breakage (HP:0040012)2.95278640
18Recurrent bronchitis (HP:0002837)2.88769481
19B lymphocytopenia (HP:0010976)2.79410823
20Abnormality of B cell number (HP:0010975)2.79410823
21Agammaglobulinemia (HP:0004432)2.68089936
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68035910
23Chronic diarrhea (HP:0002028)2.67296649
24Chronic otitis media (HP:0000389)2.66795240
25Septo-optic dysplasia (HP:0100842)2.57609532
26Eosinophilia (HP:0001880)2.56684902
27Meningitis (HP:0001287)2.55415895
28Abnormality of T cells (HP:0002843)2.54205582
29Abnormality of the prostate (HP:0008775)2.53378303
30Reticulocytopenia (HP:0001896)2.52891950
31Volvulus (HP:0002580)2.52600328
32Mediastinal lymphadenopathy (HP:0100721)2.51950655
33Recurrent skin infections (HP:0001581)2.50193546
34High anterior hairline (HP:0009890)2.49933195
35Lymphopenia (HP:0001888)2.49319033
36Protruding tongue (HP:0010808)2.49299152
37Drooling (HP:0002307)2.48444532
38Abnormal pancreas size (HP:0012094)2.47903964
39Lip pit (HP:0100267)2.47779912
40Periodontitis (HP:0000704)2.45931112
41Diastasis recti (HP:0001540)2.44311154
42Nephroblastoma (Wilms tumor) (HP:0002667)2.42606150
43Myositis (HP:0100614)2.41420962
44IgA deficiency (HP:0002720)2.41321601
45Recurrent cutaneous fungal infections (HP:0011370)2.40250723
46Chronic mucocutaneous candidiasis (HP:0002728)2.40250723
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.38888683
48Gingivitis (HP:0000230)2.38492156
49Hypoplastic labia majora (HP:0000059)2.38013510
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.37066482
51Recurrent sinusitis (HP:0011108)2.36789965
52Hypophosphatemic rickets (HP:0004912)2.36220403
53Abnormality of the labia minora (HP:0012880)2.35766854
54Acute myeloid leukemia (HP:0004808)2.34864042
55Encephalitis (HP:0002383)2.33841596
56Impulsivity (HP:0100710)2.33830237
57Autoimmune hemolytic anemia (HP:0001890)2.32962568
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.32538646
59Long eyelashes (HP:0000527)2.29768530
60Excessive salivation (HP:0003781)2.29482509
61Embryonal renal neoplasm (HP:0011794)2.29333890
62Ectopic kidney (HP:0000086)2.28318048
63Pustule (HP:0200039)2.27787543
64Abnormality of macrophages (HP:0004311)2.27705532
65Thyroiditis (HP:0100646)2.26962890
66Vasculitis (HP:0002633)2.25828519
67Abnormality of the labia majora (HP:0012881)2.25590495
68Patellar aplasia (HP:0006443)2.24012466
69Granulocytopenia (HP:0001913)2.20624027
70Esophageal atresia (HP:0002032)2.19473915
71Osteomyelitis (HP:0002754)2.18750251
72Abnormality of eosinophils (HP:0001879)2.18040673
73Hypochromic microcytic anemia (HP:0004840)2.17608909
74Abnormality of T cell physiology (HP:0011840)2.17318542
75Truncal obesity (HP:0001956)2.16130104
76Medulloblastoma (HP:0002885)2.15913424
77Recurrent pneumonia (HP:0006532)2.15768119
78Severe combined immunodeficiency (HP:0004430)2.15751890
79Pancreatic cysts (HP:0001737)2.14567345
80Papillary thyroid carcinoma (HP:0002895)2.12983367
81Facial hemangioma (HP:0000329)2.12934861
82Transitional cell carcinoma of the bladder (HP:0006740)2.11375642
83Meckel diverticulum (HP:0002245)2.10952075
84Abnormal platelet volume (HP:0011876)2.09898728
85Chorioretinal atrophy (HP:0000533)2.09122116
86Gastrointestinal carcinoma (HP:0002672)2.08787270
87Malignant gastrointestinal tract tumors (HP:0006749)2.08787270
88Chronic obstructive pulmonary disease (HP:0006510)2.08278576
89Obstructive lung disease (HP:0006536)2.08278576
90Gingival bleeding (HP:0000225)2.07621349
91Thrombocytosis (HP:0001894)2.06695101
92Elevated erythrocyte sedimentation rate (HP:0003565)2.06472191
93Missing ribs (HP:0000921)2.05862054
94Cellulitis (HP:0100658)2.05065763
95Leukocytosis (HP:0001974)2.04624757
96Keratoconjunctivitis sicca (HP:0001097)2.04036178
97Rib fusion (HP:0000902)2.03458608
98Systemic lupus erythematosus (HP:0002725)2.03171339
99IgG deficiency (HP:0004315)2.02942837
100Uterine leiomyosarcoma (HP:0002891)2.02600084
101Leiomyosarcoma (HP:0100243)2.02600084
102Pendular nystagmus (HP:0012043)2.02441132
103Chronic hepatic failure (HP:0100626)2.02405450
104Obsessive-compulsive behavior (HP:0000722)2.01699745
105Abnormality of cells of the erythroid lineage (HP:0012130)2.01585072
106Panhypogammaglobulinemia (HP:0003139)1.99875476
107Combined immunodeficiency (HP:0005387)1.99369672
108Optic neuritis (HP:0100653)1.99214115
109Retrobulbar optic neuritis (HP:0100654)1.99214115
110Arterial thrombosis (HP:0004420)1.98485610
111Abnormality of the ileum (HP:0001549)1.98406144
112Gastrointestinal infarctions (HP:0005244)1.98307496
113Joint hemorrhage (HP:0005261)1.97707742
114Aplasia/Hypoplasia of the patella (HP:0006498)1.96991817
115Anophthalmia (HP:0000528)1.96838163
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96606147
117Abnormality of the septum pellucidum (HP:0007375)1.95323312
118Pancreatic fibrosis (HP:0100732)1.95316071
119Bony spicule pigmentary retinopathy (HP:0007737)1.95219899
120Aplasia/Hypoplasia of the sternum (HP:0006714)1.94881239
121Increased IgE level (HP:0003212)1.94846268
122Aqueductal stenosis (HP:0002410)1.94747184
123Birth length less than 3rd percentile (HP:0003561)1.94719551
124Rhabdomyosarcoma (HP:0002859)1.93737931
125Hypoplasia of the thymus (HP:0000778)1.93398667
126Bladder carcinoma (HP:0002862)1.93165216
127Bladder neoplasm (HP:0009725)1.93165216
128Orchitis (HP:0100796)1.92650552
129Heterotopia (HP:0002282)1.92259480
130Inflammation of the large intestine (HP:0002037)1.91882435
131Cortical dysplasia (HP:0002539)1.91155617
132Bilateral microphthalmos (HP:0007633)1.90779198
133Neonatal hypoglycemia (HP:0001998)1.89009479
134Prostate neoplasm (HP:0100787)1.88487318
135Limb hypertonia (HP:0002509)1.88352126
136Oligodactyly (hands) (HP:0001180)1.88271191
137Stomatitis (HP:0010280)1.88059517
138Cheilitis (HP:0100825)1.87296512
139Tubular atrophy (HP:0000092)1.87210386
140Fair hair (HP:0002286)1.87127347
141Absent thumb (HP:0009777)1.86929094
142Supernumerary spleens (HP:0009799)1.86657430
143Partial agenesis of the corpus callosum (HP:0001338)1.86642923
144Keratitis (HP:0000491)1.86564424
145Sloping forehead (HP:0000340)1.86244200
146Epistaxis (HP:0000421)1.86021848
147Abnormality of the carotid arteries (HP:0005344)1.85641552
148Abnormality of chromosome segregation (HP:0002916)1.85340460
149Abnormal rod and cone electroretinograms (HP:0008323)1.84756222
150Labial hypoplasia (HP:0000066)1.83946608
151Spontaneous hematomas (HP:0007420)1.83278911
152Keratoconjunctivitis (HP:0001096)1.83191016
153Abnormality of DNA repair (HP:0003254)1.83044808
154Fat malabsorption (HP:0002630)1.82921220
155Steatorrhea (HP:0002570)1.82910011
156Scrotal hypoplasia (HP:0000046)1.82487925
157Abnormality of the renal cortex (HP:0011035)1.81532446
158Growth hormone deficiency (HP:0000824)1.80622114
159Acute lymphatic leukemia (HP:0006721)1.78970705
160Increased mean platelet volume (HP:0011877)1.78169179
161Biliary tract neoplasm (HP:0100574)1.78050133
162Colitis (HP:0002583)1.77402752
163Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77266210
164Intestinal atresia (HP:0011100)1.77138425
165Pulmonary infiltrates (HP:0002113)1.76596584
166Recurrent lower respiratory tract infections (HP:0002783)1.75865207
167Gastrointestinal stroma tumor (HP:0100723)1.75608537
168Dandy-Walker malformation (HP:0001305)1.75378266
169Abnormality of chromosome stability (HP:0003220)1.74950072
170Stomach cancer (HP:0012126)1.73297542
17111 pairs of ribs (HP:0000878)1.73159122
172Sandal gap (HP:0001852)1.72948448
173Osteomalacia (HP:0002749)1.72595735
174Anencephaly (HP:0002323)1.72302176
175Abnormal number of erythroid precursors (HP:0012131)1.71783503
176Deep palmar crease (HP:0006191)1.71777265
177Triphalangeal thumb (HP:0001199)1.71073581
178Renovascular hypertension (HP:0100817)1.71003333
179Nephronophthisis (HP:0000090)1.69883090
180Neoplasm of the liver (HP:0002896)1.69747717
181Absent septum pellucidum (HP:0001331)1.69381818
182Hypoplastic female external genitalia (HP:0012815)1.67959366
183Poikiloderma (HP:0001029)1.66116827
184Abnormality of the aortic arch (HP:0012303)1.65862806
185Spina bifida occulta (HP:0003298)1.65407352
186Optic nerve hypoplasia (HP:0000609)1.64738054
187Thyroid carcinoma (HP:0002890)1.64438052
188Abnormality of the preputium (HP:0100587)1.63874366
189Intestinal fistula (HP:0100819)1.63159923
190Embryonal neoplasm (HP:0002898)1.62590826
191Abnormal biliary tract physiology (HP:0012439)1.62333121
192Bile duct proliferation (HP:0001408)1.62333121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.21711288
2MAP3K143.05838957
3TXK2.99636848
4CASK2.91603277
5IRAK42.91557082
6MAP3K42.78900585
7IRAK32.52921727
8WNK32.50903782
9JAK32.41460795
10TYK22.22272156
11TAOK32.18913965
12CAMK1G2.18432677
13IKBKE2.13990965
14TEC2.12622999
15RPS6KA42.11125062
16FGFR21.99224112
17CDK121.89777216
18NEK91.84561720
19STK38L1.84443200
20ICK1.70857836
21STK101.70708859
22ITK1.66210768
23JAK11.64845417
24BTK1.64204245
25SIK31.63777859
26MAP2K71.61827496
27CDC71.61320918
28BRD41.58152169
29TBK11.57263116
30CHUK1.56132677
31BMPR1B1.52943649
32PNCK1.52734362
33IKBKB1.51335096
34WNK41.51075667
35EEF2K1.51068135
36TAF11.46439077
37ZAP701.45892496
38TTK1.43851845
39CLK11.41690787
40DYRK31.41002022
41FGFR31.40755251
42WNK11.40031798
43KIT1.39840308
44PIM11.38713083
45ERN11.38661749
46TYRO31.36451632
47BLK1.34704167
48FGFR41.34246010
49BRSK21.33305770
50MAP2K41.25669013
51CHEK21.25425741
52TGFBR21.21831539
53INSRR1.21025917
54CSF1R1.19524262
55MAP3K101.15188616
56ZAK1.14438523
57YES11.14021818
58SIK11.12866911
59NLK1.12592738
60SGK21.08973389
61MAP3K91.08522999
62TNIK1.08245989
63STK41.06203896
64MAP2K31.06078602
65CSK1.05850804
66TRPM71.05736908
67TLK11.05455642
68MARK31.05151365
69MAP3K61.02977739
70NEK20.98699339
71NUAK10.98529452
72PLK40.97579868
73SGK30.96494991
74SYK0.95068126
75TNK20.94997881
76RPS6KB20.94383722
77FRK0.94073687
78ATR0.93097166
79ACVR1B0.85201317
80PASK0.85166540
81FLT30.84239702
82VRK10.83444460
83LCK0.82291318
84LATS20.79498228
85STK30.77437965
86EPHA30.76547541
87HCK0.75691055
88GRK10.75376850
89STK110.73605938
90IRAK10.72006591
91ERBB30.71632960
92MKNK10.71566387
93RPS6KA50.71304358
94PLK10.69683132
95SGK2230.69287718
96SGK4940.69287718
97CSNK1E0.69279205
98PLK30.69198910
99CDK30.68434796
100AKT30.67878435
101LYN0.65555641
102STK390.65498298
103LATS10.65486361
104MAP3K30.64782286
105CHEK10.64756174
106CDK20.64731019
107WEE10.64080726
108MKNK20.63452558
109JAK20.63400310
110MAPK110.61437768
111DYRK1B0.60675267
112FGFR10.60250066
113CDK10.57782106
114EIF2AK30.57260865
115EIF2AK20.57216767
116PRKCQ0.56775148
117TGFBR10.54256593
118RPS6KA60.54245367
119SRPK10.52689156
120STK160.51897776
121DMPK0.51146674
122EPHB10.50951464
123CDK70.50838262
124LRRK20.50255403
125SIK20.50141501
126CDK60.49332911
127RPS6KC10.49219395
128RPS6KL10.49219395
129DYRK20.48961473
130PBK0.48830996
131CSNK1A1L0.48464998
132MTOR0.47988199
133PDGFRA0.47613962
134CDK80.47566183
135GSK3B0.47439727
136CSNK1D0.47286979
137TAOK20.46958099
138BMPR20.46646745
139MAP3K50.46316928
140TSSK60.44165017
141CSNK1G10.44034416
142CDK40.43752257
143MAPK140.43094493
144PRKCH0.42162560
145AKT10.41801906
146RPS6KB10.41358115
147CAMK1D0.41265586
148ATM0.41219795
149MARK20.41130486
150DYRK1A0.41028123
151PRKDC0.40952198
152MAPK80.40001738
153PTK60.39796077
154ALK0.39170998
155HIPK20.38052125
156PDGFRB0.37748101
157MELK0.37239487
158NME10.36586839
159PRKAA20.36569889
160ABL10.36342903
161CAMK40.36146831
162MAP3K130.36091151
163GRK60.35562252
164PIK3CA0.35419658
165MAPK30.35388958

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.92239865
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.46073709
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.42992216
4Basal cell carcinoma_Homo sapiens_hsa052172.36716231
5Measles_Homo sapiens_hsa051622.21068350
6Leishmaniasis_Homo sapiens_hsa051402.13778631
7mRNA surveillance pathway_Homo sapiens_hsa030152.13170359
8Staphylococcus aureus infection_Homo sapiens_hsa051502.09610513
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08588398
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06319335
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.05389616
12RNA transport_Homo sapiens_hsa030131.98093148
13Phototransduction_Homo sapiens_hsa047441.97023668
14Hedgehog signaling pathway_Homo sapiens_hsa043401.96001774
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94269537
16Herpes simplex infection_Homo sapiens_hsa051681.89074464
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81068952
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70863679
19Dorso-ventral axis formation_Homo sapiens_hsa043201.65323227
20Hematopoietic cell lineage_Homo sapiens_hsa046401.62806250
21Colorectal cancer_Homo sapiens_hsa052101.62678311
22Allograft rejection_Homo sapiens_hsa053301.62065375
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57153220
24Base excision repair_Homo sapiens_hsa034101.55369876
25Antigen processing and presentation_Homo sapiens_hsa046121.54402588
26Mismatch repair_Homo sapiens_hsa034301.54142819
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53857590
28Homologous recombination_Homo sapiens_hsa034401.53698172
29DNA replication_Homo sapiens_hsa030301.52612097
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52125931
31Endometrial cancer_Homo sapiens_hsa052131.52062347
32Steroid biosynthesis_Homo sapiens_hsa001001.51342794
33Influenza A_Homo sapiens_hsa051641.47848213
34Osteoclast differentiation_Homo sapiens_hsa043801.45472672
35Autoimmune thyroid disease_Homo sapiens_hsa053201.43528118
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.42495002
37Legionellosis_Homo sapiens_hsa051341.39477664
38Hippo signaling pathway_Homo sapiens_hsa043901.39414415
39Thyroid cancer_Homo sapiens_hsa052161.39027688
40Toxoplasmosis_Homo sapiens_hsa051451.35976359
41Non-homologous end-joining_Homo sapiens_hsa034501.35719333
42RNA polymerase_Homo sapiens_hsa030201.35130718
43Wnt signaling pathway_Homo sapiens_hsa043101.30088597
44TNF signaling pathway_Homo sapiens_hsa046681.29553715
45B cell receptor signaling pathway_Homo sapiens_hsa046621.22867462
46One carbon pool by folate_Homo sapiens_hsa006701.21726272
47ABC transporters_Homo sapiens_hsa020101.21024893
48Lysine degradation_Homo sapiens_hsa003101.20849499
49T cell receptor signaling pathway_Homo sapiens_hsa046601.19428597
50Hepatitis B_Homo sapiens_hsa051611.18826379
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16549431
52Complement and coagulation cascades_Homo sapiens_hsa046101.14685594
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13376184
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11839173
55Graft-versus-host disease_Homo sapiens_hsa053321.08961531
56Long-term depression_Homo sapiens_hsa047301.08556916
57Fanconi anemia pathway_Homo sapiens_hsa034601.07550346
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06838017
59Tuberculosis_Homo sapiens_hsa051521.05928370
60Ribosome_Homo sapiens_hsa030101.05221658
61Adherens junction_Homo sapiens_hsa045201.03289066
62Pertussis_Homo sapiens_hsa051331.02508512
63Axon guidance_Homo sapiens_hsa043601.00509211
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99322488
65Non-small cell lung cancer_Homo sapiens_hsa052230.98234185
66Vitamin digestion and absorption_Homo sapiens_hsa049770.98067598
67p53 signaling pathway_Homo sapiens_hsa041150.97492545
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.97286906
69Asthma_Homo sapiens_hsa053100.96968492
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96628961
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96246433
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95835274
73Apoptosis_Homo sapiens_hsa042100.95624966
74Cell cycle_Homo sapiens_hsa041100.95115719
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93266353
76Small cell lung cancer_Homo sapiens_hsa052220.92847704
77Retinol metabolism_Homo sapiens_hsa008300.91080610
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90634871
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.89843066
80Taste transduction_Homo sapiens_hsa047420.88859604
81Melanoma_Homo sapiens_hsa052180.88375984
82Renal cell carcinoma_Homo sapiens_hsa052110.87948491
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.87018252
84Nicotine addiction_Homo sapiens_hsa050330.86485301
85Malaria_Homo sapiens_hsa051440.85946917
86Inositol phosphate metabolism_Homo sapiens_hsa005620.85653258
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.85522473
88Choline metabolism in cancer_Homo sapiens_hsa052310.85419652
89Hepatitis C_Homo sapiens_hsa051600.84861478
90Viral myocarditis_Homo sapiens_hsa054160.84481545
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.84267189
92Pancreatic cancer_Homo sapiens_hsa052120.83820836
93Basal transcription factors_Homo sapiens_hsa030220.83175313
94Pathways in cancer_Homo sapiens_hsa052000.81451208
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81123224
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81036546
97TGF-beta signaling pathway_Homo sapiens_hsa043500.79338576
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77659086
99Folate biosynthesis_Homo sapiens_hsa007900.76918979
100ErbB signaling pathway_Homo sapiens_hsa040120.75033177
101HTLV-I infection_Homo sapiens_hsa051660.74180399
102Peroxisome_Homo sapiens_hsa041460.73788626
103RNA degradation_Homo sapiens_hsa030180.73331508
104Acute myeloid leukemia_Homo sapiens_hsa052210.72948031
105Viral carcinogenesis_Homo sapiens_hsa052030.72119122
106MAPK signaling pathway_Homo sapiens_hsa040100.72100592
107Butanoate metabolism_Homo sapiens_hsa006500.71751419
108Epstein-Barr virus infection_Homo sapiens_hsa051690.71252387
109Caffeine metabolism_Homo sapiens_hsa002320.69953289
110Tryptophan metabolism_Homo sapiens_hsa003800.69318998
111Type II diabetes mellitus_Homo sapiens_hsa049300.68572112
112Chemokine signaling pathway_Homo sapiens_hsa040620.68505379
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.67975403
114Insulin resistance_Homo sapiens_hsa049310.66644599
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66367244
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66237398
117Notch signaling pathway_Homo sapiens_hsa043300.65926893
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65470535
119mTOR signaling pathway_Homo sapiens_hsa041500.64948025
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64391160
121Fatty acid biosynthesis_Homo sapiens_hsa000610.63949681
122Chronic myeloid leukemia_Homo sapiens_hsa052200.62718879
123Prostate cancer_Homo sapiens_hsa052150.62521021
124Circadian rhythm_Homo sapiens_hsa047100.62224652
125Ovarian steroidogenesis_Homo sapiens_hsa049130.62160148
126Other glycan degradation_Homo sapiens_hsa005110.61843702
127Gap junction_Homo sapiens_hsa045400.60118453
128FoxO signaling pathway_Homo sapiens_hsa040680.58728140
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58511357
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58075574
131Melanogenesis_Homo sapiens_hsa049160.57888856
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.56492664
133Glutamatergic synapse_Homo sapiens_hsa047240.55885916
134Fatty acid degradation_Homo sapiens_hsa000710.55669321
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54981637
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54247427
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.53649028
138Alcoholism_Homo sapiens_hsa050340.52312312
139Shigellosis_Homo sapiens_hsa051310.51769624
140Spliceosome_Homo sapiens_hsa030400.51708996
141Selenocompound metabolism_Homo sapiens_hsa004500.50570354
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50286601
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50257405
144VEGF signaling pathway_Homo sapiens_hsa043700.49658354
145Olfactory transduction_Homo sapiens_hsa047400.48614580
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48399939
147Prolactin signaling pathway_Homo sapiens_hsa049170.47445729
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.46482558
149Serotonergic synapse_Homo sapiens_hsa047260.46263788
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45350201
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45099070
152Starch and sucrose metabolism_Homo sapiens_hsa005000.44915652
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.44618787
154Ras signaling pathway_Homo sapiens_hsa040140.43877195
155Nucleotide excision repair_Homo sapiens_hsa034200.43780741
156N-Glycan biosynthesis_Homo sapiens_hsa005100.43629825
157Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43344838
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42539558
159Platelet activation_Homo sapiens_hsa046110.42203897
160AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41645915
161Oocyte meiosis_Homo sapiens_hsa041140.41211280
162Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40665830
163Histidine metabolism_Homo sapiens_hsa003400.40372191
164MicroRNAs in cancer_Homo sapiens_hsa052060.40345894
165Systemic lupus erythematosus_Homo sapiens_hsa053220.40226323

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