ZSCAN23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.23786555
2presynaptic membrane assembly (GO:0097105)4.61848300
3limb bud formation (GO:0060174)4.26176072
4nucleobase catabolic process (GO:0046113)4.04467803
5presynaptic membrane organization (GO:0097090)3.94303149
6response to pheromone (GO:0019236)3.89938695
7neuron cell-cell adhesion (GO:0007158)3.75680069
8behavioral response to nicotine (GO:0035095)3.70797197
9retinal ganglion cell axon guidance (GO:0031290)3.64205528
10intraciliary transport (GO:0042073)3.51564034
11postsynaptic membrane organization (GO:0001941)3.40001823
12negative regulation of cytosolic calcium ion concentration (GO:0051481)3.37044851
13calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.36683550
14protein localization to synapse (GO:0035418)3.30712142
15olfactory bulb development (GO:0021772)3.27897914
16phosphorelay signal transduction system (GO:0000160)3.26215327
17neural tube formation (GO:0001841)3.20672447
18vocalization behavior (GO:0071625)3.16359697
19limb development (GO:0060173)3.16157991
20appendage development (GO:0048736)3.16157991
21central nervous system projection neuron axonogenesis (GO:0021952)3.07629396
22somite development (GO:0061053)3.02462045
23negative regulation of axon guidance (GO:1902668)2.99944272
24regulation of collateral sprouting (GO:0048670)2.99066011
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98874415
26cilium assembly (GO:0042384)2.97736321
27regulation of non-canonical Wnt signaling pathway (GO:2000050)2.97539347
28cilium organization (GO:0044782)2.97235862
29synapse assembly (GO:0007416)2.95097692
30nonmotile primary cilium assembly (GO:0035058)2.92630199
31DNA integration (GO:0015074)2.89846988
32epithelial cilium movement (GO:0003351)2.89810066
33regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83414714
34transmission of nerve impulse (GO:0019226)2.82199342
35sympathetic nervous system development (GO:0048485)2.81054908
36smoothened signaling pathway (GO:0007224)2.79741989
37regulation of feeding behavior (GO:0060259)2.79493124
38regulation of growth hormone secretion (GO:0060123)2.77889887
39regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77809612
40axonal fasciculation (GO:0007413)2.76472008
41central nervous system neuron axonogenesis (GO:0021955)2.76220725
42protein polyglutamylation (GO:0018095)2.76155186
43cerebral cortex radially oriented cell migration (GO:0021799)2.75721022
44positive regulation of synapse assembly (GO:0051965)2.74607470
45homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.73201267
46spinal cord development (GO:0021510)2.72920236
47cilium morphogenesis (GO:0060271)2.71546338
48neuron recognition (GO:0008038)2.70490032
49protein localization to cilium (GO:0061512)2.68404850
50negative regulation of oligodendrocyte differentiation (GO:0048715)2.68400025
51gamma-aminobutyric acid transport (GO:0015812)2.67598771
52cornea development in camera-type eye (GO:0061303)2.66901395
53mechanosensory behavior (GO:0007638)2.66700241
54neuron fate determination (GO:0048664)2.65292050
55ionotropic glutamate receptor signaling pathway (GO:0035235)2.65123944
56neuronal action potential (GO:0019228)2.63344716
57cell proliferation in forebrain (GO:0021846)2.62385131
58neuronal stem cell maintenance (GO:0097150)2.61425939
59hippocampus development (GO:0021766)2.59932658
60negative chemotaxis (GO:0050919)2.54968406
61gastrulation with mouth forming second (GO:0001702)2.54433594
62neurotransmitter-gated ion channel clustering (GO:0072578)2.54252923
63sequestering of actin monomers (GO:0042989)2.53858342
64cilium movement (GO:0003341)2.53841546
65cilium or flagellum-dependent cell motility (GO:0001539)2.50350524
66auditory behavior (GO:0031223)2.48615582
67establishment of mitochondrion localization (GO:0051654)2.45335070
68dorsal/ventral axis specification (GO:0009950)2.44863773
69regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.44638329
70negative regulation of dendrite development (GO:2000171)2.43759516
71forebrain neuron differentiation (GO:0021879)2.43600954
72regulation of synapse assembly (GO:0051963)2.43103510
73regulation of development, heterochronic (GO:0040034)2.40026333
74myoblast fusion (GO:0007520)2.39211477
75negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38661201
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.38125216
77histone H4-K12 acetylation (GO:0043983)2.37664847
78regulation of oligodendrocyte differentiation (GO:0048713)2.36851399
79negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36456198
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.36456198
81regulation of translation, ncRNA-mediated (GO:0045974)2.36456198
82renal system development (GO:0072001)2.35912293
83negative regulation of astrocyte differentiation (GO:0048712)2.35834755
84DNA double-strand break processing (GO:0000729)2.35014006
85prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.34502494
86spinal cord association neuron differentiation (GO:0021527)2.33588970
87regulation of timing of cell differentiation (GO:0048505)2.33119389
88cell differentiation in spinal cord (GO:0021515)2.32399270
89positive regulation of growth hormone secretion (GO:0060124)2.32145330
90hindbrain development (GO:0030902)2.30565145
91heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.30026950
92regulation of Rac GTPase activity (GO:0032314)2.30011487
93cellular response to cholesterol (GO:0071397)2.29750781
94behavioral response to ethanol (GO:0048149)2.29740370
95positive regulation of dendritic spine morphogenesis (GO:0061003)2.28907836
96serotonin metabolic process (GO:0042428)2.27304128
97cellular component assembly involved in morphogenesis (GO:0010927)2.26592223
98retinal cone cell development (GO:0046549)2.25958813
99organelle disassembly (GO:1903008)2.25651825
100positive regulation of gastrulation (GO:2000543)2.25539002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.63915218
2IGF1R_20145208_ChIP-Seq_DFB_Human3.45647066
3GBX2_23144817_ChIP-Seq_PC3_Human3.43972534
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.16192815
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.95474122
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.91337686
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87040992
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80924078
9TAF15_26573619_Chip-Seq_HEK293_Human2.70467423
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69585617
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65741696
12ZNF274_21170338_ChIP-Seq_K562_Hela2.64317819
13FUS_26573619_Chip-Seq_HEK293_Human2.46447593
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40766378
15EWS_26573619_Chip-Seq_HEK293_Human2.34565969
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32972471
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26594023
18P300_19829295_ChIP-Seq_ESCs_Human2.11904698
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.05416459
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95777470
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94284673
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92827862
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89128899
24VDR_22108803_ChIP-Seq_LS180_Human1.88409790
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.85571453
26SMAD4_21799915_ChIP-Seq_A2780_Human1.85380297
27* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79416179
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.76351441
29RNF2_27304074_Chip-Seq_NSC_Mouse1.74047332
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72370648
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68401507
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67482023
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58377640
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57940132
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57461399
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.54921626
37IRF1_19129219_ChIP-ChIP_H3396_Human1.49396299
38AR_25329375_ChIP-Seq_VCAP_Human1.47942299
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47170152
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44983749
41STAT3_23295773_ChIP-Seq_U87_Human1.44288687
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41051189
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39946809
44CBP_20019798_ChIP-Seq_JUKART_Human1.39879740
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39879740
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.38860226
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.38274324
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.37856979
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36897055
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36412857
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36412857
52AR_21572438_ChIP-Seq_LNCaP_Human1.34047593
53RUNX2_22187159_ChIP-Seq_PCA_Human1.33699235
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33412433
55ER_23166858_ChIP-Seq_MCF-7_Human1.32934693
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30857690
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30831751
58SOX9_26525672_Chip-Seq_HEART_Mouse1.29538684
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28544097
60TCF4_23295773_ChIP-Seq_U87_Human1.28234083
61TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26158984
62TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25036323
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.24926303
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23916793
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23198399
66MYC_18940864_ChIP-ChIP_HL60_Human1.22422784
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22346387
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.21831707
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19910622
70REST_21632747_ChIP-Seq_MESCs_Mouse1.19650548
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17831850
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17343504
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.16232716
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13361252
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12822128
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11725930
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10792534
78TCF4_22108803_ChIP-Seq_LS180_Human1.09272410
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.08213835
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08193820
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07829034
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07079290
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06825891
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06760235
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06746730
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06587637
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06215045
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.04371104
89* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04085886
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.03709766
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02571174
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.02044027
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01494379
94BCAT_22108803_ChIP-Seq_LS180_Human0.99730758
95JUN_21703547_ChIP-Seq_K562_Human0.99575811
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97072245
97REST_18959480_ChIP-ChIP_MESCs_Mouse0.96755889
98* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95665282
99POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93905220
100P53_22387025_ChIP-Seq_ESCs_Mouse0.93649245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.34256016
2MP0006292_abnormal_olfactory_placode2.72971607
3MP0002822_catalepsy2.65870958
4MP0002102_abnormal_ear_morphology2.62898849
5MP0005248_abnormal_Harderian_gland2.46657791
6MP0000778_abnormal_nervous_system2.32673855
7MP0002234_abnormal_pharynx_morphology2.29774196
8MP0001529_abnormal_vocalization2.28795937
9MP0010030_abnormal_orbit_morphology2.27537804
10MP0002938_white_spotting2.24563334
11MP0002653_abnormal_ependyma_morphology2.03562185
12MP0004270_analgesia2.00229442
13MP0003890_abnormal_embryonic-extraembry1.93488622
14MP0001293_anophthalmia1.90632402
15MP0003136_yellow_coat_color1.89921074
16MP0002751_abnormal_autonomic_nervous1.83197056
17MP0006276_abnormal_autonomic_nervous1.81141357
18MP0003122_maternal_imprinting1.80338498
19MP0008789_abnormal_olfactory_epithelium1.75027111
20MP0008877_abnormal_DNA_methylation1.74352344
21MP0005394_taste/olfaction_phenotype1.72849043
22MP0005499_abnormal_olfactory_system1.72849043
23MP0004133_heterotaxia1.71411867
24MP0006072_abnormal_retinal_apoptosis1.70786917
25MP0009046_muscle_twitch1.68045200
26MP0001486_abnormal_startle_reflex1.67071393
27MP0001984_abnormal_olfaction1.59048746
28MP0000631_abnormal_neuroendocrine_gland1.57575851
29MP0002233_abnormal_nose_morphology1.57336548
30MP0005253_abnormal_eye_physiology1.56136421
31MP0003121_genomic_imprinting1.54735646
32MP0003937_abnormal_limbs/digits/tail_de1.51467928
33MP0001968_abnormal_touch/_nociception1.51296161
34MP0005171_absent_coat_pigmentation1.48988369
35MP0000566_synostosis1.46186849
36MP0005423_abnormal_somatic_nervous1.45316974
37MP0002638_abnormal_pupillary_reflex1.40226873
38MP0003635_abnormal_synaptic_transmissio1.39531350
39MP0003385_abnormal_body_wall1.38533969
40MP0002736_abnormal_nociception_after1.35233182
41MP0000049_abnormal_middle_ear1.34468788
42MP0003938_abnormal_ear_development1.34139969
43MP0002734_abnormal_mechanical_nocicepti1.33209879
44MP0000955_abnormal_spinal_cord1.29817497
45MP0009745_abnormal_behavioral_response1.29366041
46MP0002735_abnormal_chemical_nociception1.29046869
47MP0003787_abnormal_imprinting1.27651439
48MP0002184_abnormal_innervation1.27107159
49MP0003861_abnormal_nervous_system1.26954950
50MP0005391_vision/eye_phenotype1.24995826
51MP0003119_abnormal_digestive_system1.22980335
52MP0001286_abnormal_eye_development1.22702853
53MP0005646_abnormal_pituitary_gland1.22564629
54MP0002272_abnormal_nervous_system1.22512780
55MP0002064_seizures1.21595280
56MP0005187_abnormal_penis_morphology1.20976875
57MP0005551_abnormal_eye_electrophysiolog1.20049225
58MP0002572_abnormal_emotion/affect_behav1.19671546
59MP0001346_abnormal_lacrimal_gland1.17889791
60MP0004859_abnormal_synaptic_plasticity1.16643083
61MP0004145_abnormal_muscle_electrophysio1.13074519
62MP0003755_abnormal_palate_morphology1.10814516
63MP0004924_abnormal_behavior1.10241031
64MP0005386_behavior/neurological_phenoty1.10241031
65MP0002063_abnormal_learning/memory/cond1.09832353
66MP0002152_abnormal_brain_morphology1.09464491
67MP0002752_abnormal_somatic_nervous1.08094658
68MP0002697_abnormal_eye_size1.07924724
69MP0002557_abnormal_social/conspecific_i1.07201520
70MP0002882_abnormal_neuron_morphology1.06455802
71MP0002282_abnormal_trachea_morphology1.05230393
72MP0005195_abnormal_posterior_eye1.04834367
73MP0002067_abnormal_sensory_capabilities1.04402115
74MP0004142_abnormal_muscle_tone1.01851282
75MP0003935_abnormal_craniofacial_develop1.01331640
76MP0001485_abnormal_pinna_reflex1.01166228
77MP0005645_abnormal_hypothalamus_physiol0.98891769
78MP0000647_abnormal_sebaceous_gland0.98795817
79MP0008058_abnormal_DNA_repair0.98763786
80MP0004811_abnormal_neuron_physiology0.97348857
81MP0003567_abnormal_fetal_cardiomyocyte0.97078115
82MP0000026_abnormal_inner_ear0.95257353
83MP0002092_abnormal_eye_morphology0.94069063
84MP0000428_abnormal_craniofacial_morphol0.93277560
85MP0001299_abnormal_eye_distance/0.89476594
86MP0003693_abnormal_embryo_hatching0.88575002
87MP0002090_abnormal_vision0.87831269
88MP0000534_abnormal_ureter_morphology0.87552451
89MP0003011_delayed_dark_adaptation0.86558171
90MP0000569_abnormal_digit_pigmentation0.85796335
91MP0002733_abnormal_thermal_nociception0.84062665
92MP0002837_dystrophic_cardiac_calcinosis0.83684601
93MP0010094_abnormal_chromosome_stability0.83179206
94MP0003942_abnormal_urinary_system0.82949218
95MP0001970_abnormal_pain_threshold0.82239218
96MP0009703_decreased_birth_body0.80246946
97MP0000516_abnormal_urinary_system0.79772830
98MP0005367_renal/urinary_system_phenotyp0.79772830
99MP0004742_abnormal_vestibular_system0.79341271
100MP0002249_abnormal_larynx_morphology0.78687740

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.76539382
2Gait imbalance (HP:0002141)3.39760213
3True hermaphroditism (HP:0010459)3.34277668
4Pancreatic fibrosis (HP:0100732)3.34193822
5Congenital primary aphakia (HP:0007707)3.32246410
6Nephrogenic diabetes insipidus (HP:0009806)3.26301785
7Genital tract atresia (HP:0001827)3.24455183
8Vaginal atresia (HP:0000148)3.18846082
9Pancreatic cysts (HP:0001737)3.16636721
10Abnormality of the labia minora (HP:0012880)2.92387489
11Optic nerve hypoplasia (HP:0000609)2.89420309
12Poor coordination (HP:0002370)2.75807793
13Midline defect of the nose (HP:0004122)2.70543444
14Drooling (HP:0002307)2.70375876
15Hyperventilation (HP:0002883)2.69421920
16Nephronophthisis (HP:0000090)2.58447882
17Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.48502977
18Cystic liver disease (HP:0006706)2.47560234
19Intestinal atresia (HP:0011100)2.46428123
20Type II lissencephaly (HP:0007260)2.45855706
21Postaxial foot polydactyly (HP:0001830)2.44113055
22Hypoplastic pelvis (HP:0008839)2.43969282
23Aplasia/Hypoplasia of the tongue (HP:0010295)2.43579545
24Excessive salivation (HP:0003781)2.41141615
25High anterior hairline (HP:0009890)2.40483220
26Hepatoblastoma (HP:0002884)2.39957362
27Postaxial hand polydactyly (HP:0001162)2.32950940
28Lissencephaly (HP:0001339)2.31738486
29Abnormality of the astrocytes (HP:0100707)2.31449879
30Astrocytoma (HP:0009592)2.31449879
31Supernumerary spleens (HP:0009799)2.29840511
32Specific learning disability (HP:0001328)2.27638943
33Septo-optic dysplasia (HP:0100842)2.26052702
34Broad foot (HP:0001769)2.23970431
35Preaxial hand polydactyly (HP:0001177)2.21776302
36Abnormality of midbrain morphology (HP:0002418)2.21247050
37Molar tooth sign on MRI (HP:0002419)2.21247050
38Sclerocornea (HP:0000647)2.17181428
39Abnormality of the renal medulla (HP:0100957)2.16639923
40Short 4th metacarpal (HP:0010044)2.15277110
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15277110
42Medulloblastoma (HP:0002885)2.15147449
43Glioma (HP:0009733)2.14905904
44Cutaneous finger syndactyly (HP:0010554)2.12978844
45Cortical dysplasia (HP:0002539)2.11499448
46Anencephaly (HP:0002323)2.09623075
47Inability to walk (HP:0002540)2.09417604
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.08736509
49Colon cancer (HP:0003003)2.06507727
50Gastrointestinal atresia (HP:0002589)2.05055466
51Focal motor seizures (HP:0011153)2.04336459
52Anophthalmia (HP:0000528)2.02685537
53Renal hypoplasia (HP:0000089)2.00797940
54Amblyopia (HP:0000646)1.99673918
55Decreased testicular size (HP:0008734)1.99141307
56Dandy-Walker malformation (HP:0001305)1.98356148
57Esophageal atresia (HP:0002032)1.98164480
58Patellar aplasia (HP:0006443)1.97924690
59Progressive cerebellar ataxia (HP:0002073)1.96114425
60Micropenis (HP:0000054)1.95886276
61Rhabdomyosarcoma (HP:0002859)1.94716378
62Exotropia (HP:0000577)1.92164772
63Chorioretinal atrophy (HP:0000533)1.91997708
64Oligodactyly (hands) (HP:0001180)1.91486395
65Retinal dysplasia (HP:0007973)1.89801229
66Aplasia/Hypoplasia of the sternum (HP:0006714)1.88132635
67Cerebellar dysplasia (HP:0007033)1.87620953
68Aqueductal stenosis (HP:0002410)1.86626207
69Increased number of teeth (HP:0011069)1.86406226
70Preaxial foot polydactyly (HP:0001841)1.86368559
71Oligodactyly (HP:0012165)1.86088378
72Curly hair (HP:0002212)1.85427251
73Abnormality of the parathyroid morphology (HP:0011766)1.82220588
74Hemiparesis (HP:0001269)1.80838281
75Abnormal lung lobation (HP:0002101)1.80693089
76Tented upper lip vermilion (HP:0010804)1.80396941
77Aplasia/Hypoplasia of the patella (HP:0006498)1.79970805
78Febrile seizures (HP:0002373)1.79894084
79Progressive inability to walk (HP:0002505)1.78904395
80Cutaneous syndactyly (HP:0012725)1.78705131
81Aplasia/Hypoplasia of the lens (HP:0008063)1.76278814
82Congenital hepatic fibrosis (HP:0002612)1.74706992
83Tubulointerstitial nephritis (HP:0001970)1.74682996
84Short foot (HP:0001773)1.73039851
85Chronic hepatic failure (HP:0100626)1.72761389
86Pachygyria (HP:0001302)1.72543038
87Abnormality of abdominal situs (HP:0011620)1.71743526
88Abdominal situs inversus (HP:0003363)1.71743526
89Neoplasm of the adrenal cortex (HP:0100641)1.71272658
90Short tibia (HP:0005736)1.70286693
91Hyperglycinemia (HP:0002154)1.70050430
92Broad-based gait (HP:0002136)1.69913354
93Meningocele (HP:0002435)1.69375795
94Abnormality of the 4th metacarpal (HP:0010012)1.68504320
95Volvulus (HP:0002580)1.67469921
96Focal seizures (HP:0007359)1.66413927
97Neoplasm of striated muscle (HP:0009728)1.65900107
98Occipital encephalocele (HP:0002085)1.65304218
99Tubular atrophy (HP:0000092)1.64330282
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64007410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.60875982
2MAP3K43.24158693
3CASK3.03358642
4MARK12.71379810
5MAP4K22.51357789
6BCR2.46518237
7TNIK2.45743464
8EPHA32.35466691
9TRIM282.31119276
10EPHA42.28339192
11SRPK12.21595990
12FRK2.18826097
13MAP2K72.17884519
14MAPK132.10644106
15ERBB31.94924267
16STK38L1.88459893
17CSNK1G11.74998604
18DYRK21.71664481
19STK241.61480524
20CSNK1G21.60826940
21ZAK1.57792817
22CSNK1G31.55299610
23BMPR1B1.53828363
24PAK31.50270631
25CSNK1A1L1.36308496
26EPHB21.35977409
27ACVR1B1.34821776
28CDK191.30534637
29SGK21.28129073
30BRD41.24415805
31DYRK31.21048897
32PNCK1.20460221
33MKNK21.16724112
34STK31.15078048
35MKNK11.14265355
36FGFR21.13868102
37IRAK11.13829734
38SGK2231.06120982
39SGK4941.06120982
40VRK11.02415493
41AKT31.01997109
42INSRR1.01943657
43PLK31.01095787
44NTRK21.00723127
45PINK10.97944752
46TSSK60.97231763
47ADRBK20.96161677
48MINK10.93898679
49NUAK10.87599295
50MAP2K40.83501292
51PRKCG0.83082788
52PLK10.82741240
53CDC70.81160393
54BRSK20.81051032
55PLK20.78744062
56PKN10.77642959
57CAMK1G0.76979222
58CDK30.75681102
59ADRBK10.75403725
60PLK40.74909371
61UHMK10.70043286
62OXSR10.67421631
63PRKCE0.64310057
64ATR0.62795412
65PAK60.61543386
66DYRK1A0.58642228
67RPS6KA40.56604609
68CDK50.55798408
69ATM0.55770984
70GRK10.53980763
71WEE10.53789807
72IRAK20.53313398
73DYRK1B0.52957570
74OBSCN0.52736702
75CAMK2A0.52574791
76TGFBR10.52152661
77PRKAA10.50288326
78CHEK20.49073139
79CAMK40.48371178
80LATS10.48367112
81CAMKK20.48000193
82GRK70.47602875
83CSNK1A10.45090971
84SGK30.42898518
85CAMK1D0.42547657
86BUB10.42510153
87FLT30.40574882
88AKT20.40267623
89CSNK1D0.39879986
90CAMK2B0.39175138
91BCKDK0.38897170
92KSR10.38128513
93FGFR10.37578405
94STK390.37417609
95MAPK150.35194698
96NLK0.33157160
97PRKD30.32816518
98FER0.32810240
99PRKDC0.31087889
100ERBB20.31018556

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.73275859
2Nicotine addiction_Homo sapiens_hsa050333.52041096
3Fanconi anemia pathway_Homo sapiens_hsa034602.64530683
4Protein export_Homo sapiens_hsa030602.53249100
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.27343954
6Hedgehog signaling pathway_Homo sapiens_hsa043402.06537910
7Basal cell carcinoma_Homo sapiens_hsa052172.06456959
8Butanoate metabolism_Homo sapiens_hsa006502.06107482
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02544952
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.00243577
11Homologous recombination_Homo sapiens_hsa034401.90282354
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87747921
13Steroid biosynthesis_Homo sapiens_hsa001001.85144784
14Non-homologous end-joining_Homo sapiens_hsa034501.80954025
15Phototransduction_Homo sapiens_hsa047441.76817990
16Axon guidance_Homo sapiens_hsa043601.75399435
17Glutamatergic synapse_Homo sapiens_hsa047241.74486368
18Circadian entrainment_Homo sapiens_hsa047131.71015441
19Taste transduction_Homo sapiens_hsa047421.70995546
20Propanoate metabolism_Homo sapiens_hsa006401.67545480
21Long-term depression_Homo sapiens_hsa047301.57084932
22Hippo signaling pathway_Homo sapiens_hsa043901.48346786
23Dopaminergic synapse_Homo sapiens_hsa047281.47282440
24Mismatch repair_Homo sapiens_hsa034301.47188047
25GABAergic synapse_Homo sapiens_hsa047271.42715819
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39980694
27Cocaine addiction_Homo sapiens_hsa050301.36219380
28RNA polymerase_Homo sapiens_hsa030201.33349804
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.26482519
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26253033
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25919027
32Basal transcription factors_Homo sapiens_hsa030221.24386996
33Morphine addiction_Homo sapiens_hsa050321.23769720
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20823155
35Olfactory transduction_Homo sapiens_hsa047401.17621366
36Amphetamine addiction_Homo sapiens_hsa050311.17128761
37Alcoholism_Homo sapiens_hsa050341.14239168
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09135811
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06621988
40Dorso-ventral axis formation_Homo sapiens_hsa043201.02180375
41Insulin secretion_Homo sapiens_hsa049110.99349090
42Wnt signaling pathway_Homo sapiens_hsa043100.97053708
43Ether lipid metabolism_Homo sapiens_hsa005650.95196633
44Serotonergic synapse_Homo sapiens_hsa047260.93985030
45Cholinergic synapse_Homo sapiens_hsa047250.93857782
46TGF-beta signaling pathway_Homo sapiens_hsa043500.90989545
47RNA degradation_Homo sapiens_hsa030180.89439363
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87444777
49mRNA surveillance pathway_Homo sapiens_hsa030150.86031206
50Tryptophan metabolism_Homo sapiens_hsa003800.85132248
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84916400
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84729114
53Lysine degradation_Homo sapiens_hsa003100.84624899
54Selenocompound metabolism_Homo sapiens_hsa004500.84207874
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83653082
56Nucleotide excision repair_Homo sapiens_hsa034200.83327538
57Huntingtons disease_Homo sapiens_hsa050160.79493833
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78885806
59Linoleic acid metabolism_Homo sapiens_hsa005910.77902472
60Melanogenesis_Homo sapiens_hsa049160.72858021
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70486530
62RNA transport_Homo sapiens_hsa030130.68295914
63Gap junction_Homo sapiens_hsa045400.67786273
64Oocyte meiosis_Homo sapiens_hsa041140.66543917
65Oxidative phosphorylation_Homo sapiens_hsa001900.66270019
66Cell cycle_Homo sapiens_hsa041100.64807522
67Cardiac muscle contraction_Homo sapiens_hsa042600.61793230
68Salivary secretion_Homo sapiens_hsa049700.61073925
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60507773
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59457020
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59432543
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.58911886
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.57120080
74Circadian rhythm_Homo sapiens_hsa047100.55184018
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51703406
76Spliceosome_Homo sapiens_hsa030400.49311308
77p53 signaling pathway_Homo sapiens_hsa041150.48873288
78Base excision repair_Homo sapiens_hsa034100.48487220
79cAMP signaling pathway_Homo sapiens_hsa040240.48360177
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48218269
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48175175
82Peroxisome_Homo sapiens_hsa041460.48124698
83Colorectal cancer_Homo sapiens_hsa052100.47628373
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47105185
85Parkinsons disease_Homo sapiens_hsa050120.45322018
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43714918
87Calcium signaling pathway_Homo sapiens_hsa040200.42595385
88Melanoma_Homo sapiens_hsa052180.42261216
89Purine metabolism_Homo sapiens_hsa002300.42171619
90Tight junction_Homo sapiens_hsa045300.41992357
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.40220818
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39456080
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38148543
94Thyroid hormone synthesis_Homo sapiens_hsa049180.36486881
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36070084
96Nitrogen metabolism_Homo sapiens_hsa009100.34294588
97Renin secretion_Homo sapiens_hsa049240.33794782
98Systemic lupus erythematosus_Homo sapiens_hsa053220.33568914
99Oxytocin signaling pathway_Homo sapiens_hsa049210.32168785
100Dilated cardiomyopathy_Homo sapiens_hsa054140.31832188

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