ZSCAN22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.53562838
2DNA deamination (GO:0045006)8.04476456
3proline metabolic process (GO:0006560)7.14505623
4sphingosine metabolic process (GO:0006670)7.13068036
5replication fork processing (GO:0031297)7.07111443
6transcription from mitochondrial promoter (GO:0006390)6.93382917
7embryonic process involved in female pregnancy (GO:0060136)6.71700354
8diol metabolic process (GO:0034311)6.54349567
9sphingoid metabolic process (GO:0046519)6.24763523
10DNA strand renaturation (GO:0000733)6.11130246
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.04068236
12fucose catabolic process (GO:0019317)5.80935534
13L-fucose metabolic process (GO:0042354)5.80935534
14L-fucose catabolic process (GO:0042355)5.80935534
15telomere maintenance via semi-conservative replication (GO:0032201)5.51600669
16positive regulation of protein homooligomerization (GO:0032464)5.46854827
17somatic diversification of immune receptors via somatic mutation (GO:0002566)5.22862343
18somatic hypermutation of immunoglobulin genes (GO:0016446)5.22862343
19mitochondrial DNA metabolic process (GO:0032042)5.10270366
20oxidative demethylation (GO:0070989)5.10215178
21DNA methylation involved in gamete generation (GO:0043046)5.08445097
22DNA strand elongation involved in DNA replication (GO:0006271)5.05758622
23poly(A)+ mRNA export from nucleus (GO:0016973)4.98571914
24regulation of protein homooligomerization (GO:0032462)4.90777933
25nucleotide-excision repair, DNA gap filling (GO:0006297)4.78643515
26formation of translation preinitiation complex (GO:0001731)4.76311617
27DNA strand elongation (GO:0022616)4.74763584
28mRNA cleavage (GO:0006379)4.73523993
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.69273043
30establishment of apical/basal cell polarity (GO:0035089)4.63143247
31piRNA metabolic process (GO:0034587)4.54169987
32viral mRNA export from host cell nucleus (GO:0046784)4.51887848
33base-excision repair (GO:0006284)4.49614553
34telomere maintenance via recombination (GO:0000722)4.41991323
35protein-chromophore linkage (GO:0018298)4.34108404
36regulation of integrin activation (GO:0033623)4.33880753
37lipopolysaccharide biosynthetic process (GO:0009103)4.32921284
38regulation of meiosis I (GO:0060631)4.23966801
39cellular response to zinc ion (GO:0071294)4.19547820
40positive regulation of developmental pigmentation (GO:0048087)4.17115722
41negative regulation of mRNA processing (GO:0050686)4.17029520
42regulation of translational fidelity (GO:0006450)4.16741979
43base-excision repair, AP site formation (GO:0006285)4.15453130
44regulation of double-strand break repair via homologous recombination (GO:0010569)4.14077915
45heme transport (GO:0015886)4.10055327
46cellular ketone body metabolic process (GO:0046950)4.08489119
47mitotic G1 DNA damage checkpoint (GO:0031571)4.06161447
48establishment of monopolar cell polarity (GO:0061162)4.05718628
49establishment or maintenance of monopolar cell polarity (GO:0061339)4.05718628
50termination of RNA polymerase II transcription (GO:0006369)4.03254830
51dosage compensation (GO:0007549)4.01883571
52DNA ligation (GO:0006266)3.97206180
53maturation of 5.8S rRNA (GO:0000460)3.93998156
54negative regulation of cell cycle arrest (GO:0071157)3.91867390
55telomere maintenance via telomere lengthening (GO:0010833)3.90710765
56sulfate transmembrane transport (GO:1902358)3.85439777
57regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.84645031
58protein prenylation (GO:0018342)3.83590348
59prenylation (GO:0097354)3.83590348
60negative regulation of telomere maintenance (GO:0032205)3.82721812
61spliceosomal tri-snRNP complex assembly (GO:0000244)3.81489348
62embryonic placenta development (GO:0001892)3.81229875
63cellular response to ATP (GO:0071318)3.80836389
64negative regulation of RNA splicing (GO:0033119)3.80650866
65meiotic chromosome segregation (GO:0045132)3.78116179
66negative regulation of JAK-STAT cascade (GO:0046426)3.76983063
67double-strand break repair via nonhomologous end joining (GO:0006303)3.76394250
68non-recombinational repair (GO:0000726)3.76394250
69mitotic recombination (GO:0006312)3.76121693
70DNA topological change (GO:0006265)3.75041399
71regulation of double-strand break repair (GO:2000779)3.74334506
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.69498018
73behavioral response to nicotine (GO:0035095)3.68992650
74DNA integration (GO:0015074)3.67914073
75DNA double-strand break processing (GO:0000729)3.65725113
76glutamine family amino acid biosynthetic process (GO:0009084)3.65373058
77mitochondrial RNA metabolic process (GO:0000959)3.65238058
78ketone body metabolic process (GO:1902224)3.65110551
79lipopolysaccharide metabolic process (GO:0008653)3.60910420
80sulfate transport (GO:0008272)3.59845154
81kinetochore assembly (GO:0051382)3.59043616
82regulation of rhodopsin mediated signaling pathway (GO:0022400)3.54307562
83G1 DNA damage checkpoint (GO:0044783)3.52692417
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52190697
85negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.44484465
86mitotic G1/S transition checkpoint (GO:0044819)3.44044559
87histone H4-K12 acetylation (GO:0043983)3.42798859
88mannosylation (GO:0097502)3.38201276
89establishment of protein localization to mitochondrial membrane (GO:0090151)3.38113904
90rhodopsin mediated signaling pathway (GO:0016056)3.37776932
91regulation of pigment cell differentiation (GO:0050932)3.35447569
92negative regulation of mRNA metabolic process (GO:1903312)3.35078078
93water-soluble vitamin biosynthetic process (GO:0042364)3.33824235
94nuclear envelope reassembly (GO:0031468)3.30774114
95mitotic nuclear envelope reassembly (GO:0007084)3.30774114
96nodal signaling pathway (GO:0038092)3.30712278
97regulation of DNA damage checkpoint (GO:2000001)3.30527077
98positive regulation by host of viral transcription (GO:0043923)3.26871896
99negative regulation of protein oligomerization (GO:0032460)3.26588050
100erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.26509566
101L-phenylalanine catabolic process (GO:0006559)3.26509566
102DNA demethylation (GO:0080111)3.26353715
103negative regulation of DNA-dependent DNA replication (GO:2000104)3.24206847
104mRNA export from nucleus (GO:0006406)3.23930009
105kinetochore organization (GO:0051383)3.22990958
106aromatic amino acid family catabolic process (GO:0009074)3.20648838
107indolalkylamine metabolic process (GO:0006586)3.19802936
108convergent extension (GO:0060026)3.18117654
109pseudouridine synthesis (GO:0001522)3.17553282
110tryptophan catabolic process (GO:0006569)3.15439302
111indole-containing compound catabolic process (GO:0042436)3.15439302
112indolalkylamine catabolic process (GO:0046218)3.15439302
113response to pheromone (GO:0019236)3.15436779
114ribosome biogenesis (GO:0042254)3.13629412
115mitochondrial DNA replication (GO:0006264)3.12354582
116kynurenine metabolic process (GO:0070189)3.11801684
117dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.11532112
118mitotic sister chromatid segregation (GO:0000070)3.11085091
119positive regulation of DNA repair (GO:0045739)3.10972034
120fucosylation (GO:0036065)3.07845132
121RNA export from nucleus (GO:0006405)3.04790785
122serotonin receptor signaling pathway (GO:0007210)3.03855392
123positive regulation of protein oligomerization (GO:0032461)3.03593602
124centriole replication (GO:0007099)3.03285120
125iron coordination entity transport (GO:1901678)3.02764939
126GDP-mannose metabolic process (GO:0019673)3.01852826
127recombinational repair (GO:0000725)3.00325768
128double-strand break repair via homologous recombination (GO:0000724)2.99652781
129positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98884922
130positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98884922
131positive regulation of mitotic sister chromatid separation (GO:1901970)2.98884922
132protein import into peroxisome matrix (GO:0016558)2.98547776
133primitive streak formation (GO:0090009)2.97515098
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97159009
135glycerophospholipid catabolic process (GO:0046475)2.95261067
136preassembly of GPI anchor in ER membrane (GO:0016254)2.93872234
137regulation of protein oligomerization (GO:0032459)2.92241170
138resolution of meiotic recombination intermediates (GO:0000712)2.91303628
139regulation of DNA repair (GO:0006282)2.91193652
140DNA replication initiation (GO:0006270)2.91040958
141mRNA polyadenylation (GO:0006378)2.90418646
142regulation of RNA export from nucleus (GO:0046831)2.89515288
143regulation of protein glycosylation (GO:0060049)2.89213941
144somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.88930342
145somatic cell DNA recombination (GO:0016444)2.88930342
146positive regulation of meiosis (GO:0045836)2.87795599
147DNA unwinding involved in DNA replication (GO:0006268)2.87644884
148protein K63-linked deubiquitination (GO:0070536)2.87582514
149somite rostral/caudal axis specification (GO:0032525)2.86715145
150rRNA catabolic process (GO:0016075)2.86615534
151DNA dealkylation (GO:0035510)2.86542655
152auditory receptor cell stereocilium organization (GO:0060088)2.86066659
153toxin metabolic process (GO:0009404)2.86030510
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84811937
155glycerol metabolic process (GO:0006071)2.83568004
156hematopoietic stem cell proliferation (GO:0071425)2.83000487
157cornea development in camera-type eye (GO:0061303)2.81168175
158negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80717219
159reciprocal DNA recombination (GO:0035825)2.79636182
160reciprocal meiotic recombination (GO:0007131)2.79636182
161aromatic amino acid family metabolic process (GO:0009072)2.76234517
162tryptophan metabolic process (GO:0006568)2.75361638
163ribonucleoprotein complex disassembly (GO:0032988)2.75039778
164paraxial mesoderm development (GO:0048339)2.72121674
165vitamin transmembrane transport (GO:0035461)2.69615849
166positive regulation of meiotic cell cycle (GO:0051446)2.67454984
167sulfur compound transport (GO:0072348)2.66809335
168lysine metabolic process (GO:0006553)2.66307755
169lysine catabolic process (GO:0006554)2.66307755
170detection of light stimulus involved in sensory perception (GO:0050962)2.65782458
171detection of light stimulus involved in visual perception (GO:0050908)2.65782458
172peptidyl-histidine modification (GO:0018202)2.65702425
173sympathetic nervous system development (GO:0048485)2.64759667
174aspartate family amino acid catabolic process (GO:0009068)2.63263704
175pantothenate metabolic process (GO:0015939)2.60822087
176tyrosine metabolic process (GO:0006570)2.60509985
177platelet dense granule organization (GO:0060155)2.60181321
178negative regulation of cell cycle G2/M phase transition (GO:1902750)2.57808949
179UDP-N-acetylglucosamine metabolic process (GO:0006047)2.57230961
180reflex (GO:0060004)2.54305964
181respiratory chain complex IV assembly (GO:0008535)2.53738409
182regulation of hippo signaling (GO:0035330)2.53526049
183erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.52508665
184L-phenylalanine metabolic process (GO:0006558)2.52508665
185L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.50955390
186proteasome assembly (GO:0043248)2.49324298
187RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.48887704
188organelle disassembly (GO:1903008)2.48711373
189regulation of telomere maintenance (GO:0032204)2.48300222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28279853
2ZNF274_21170338_ChIP-Seq_K562_Hela3.88901297
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.70262736
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.41040475
5IGF1R_20145208_ChIP-Seq_DFB_Human3.33487055
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22537141
7VDR_22108803_ChIP-Seq_LS180_Human3.21980459
8AR_21572438_ChIP-Seq_LNCaP_Human2.94787606
9GBX2_23144817_ChIP-Seq_PC3_Human2.80254531
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.73815917
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71000784
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59686785
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.57450578
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.56104531
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.54913660
16VDR_21846776_ChIP-Seq_THP-1_Human2.50203366
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41420919
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41392037
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38500655
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38202755
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33385073
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26908994
23P300_19829295_ChIP-Seq_ESCs_Human2.21745134
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20784417
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11612487
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09785324
27MYC_22102868_ChIP-Seq_BL_Human2.09738091
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.09485213
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06164655
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06164655
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06164655
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05074439
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.01934802
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95103260
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94457185
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93051332
37ER_23166858_ChIP-Seq_MCF-7_Human1.91130451
38* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90647574
39EWS_26573619_Chip-Seq_HEK293_Human1.89111545
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81557991
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79996841
42* ETS1_20019798_ChIP-Seq_JURKAT_Human1.79237289
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76894362
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.76571432
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73014915
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72586552
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.72246365
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72095076
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70436363
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69414368
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68665793
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66868479
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65015604
54TP53_22573176_ChIP-Seq_HFKS_Human1.63972587
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63894917
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62938684
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62730110
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62269571
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.62113486
60FUS_26573619_Chip-Seq_HEK293_Human1.61594747
61TAF15_26573619_Chip-Seq_HEK293_Human1.61555827
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.60493751
63POU5F1_16518401_ChIP-PET_MESCs_Mouse1.59351785
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59258056
65* GABP_19822575_ChIP-Seq_HepG2_Human1.58654417
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.57432964
67TCF3_18692474_ChIP-Seq_MESCs_Mouse1.57110064
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55487364
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.53768479
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53530702
71STAT3_23295773_ChIP-Seq_U87_Human1.52986984
72EZH2_22144423_ChIP-Seq_EOC_Human1.52254838
73XRN2_22483619_ChIP-Seq_HELA_Human1.51752017
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50064932
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48780707
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48485395
77TTF2_22483619_ChIP-Seq_HELA_Human1.46411828
78* NANOG_19829295_ChIP-Seq_ESCs_Human1.46133192
79* SOX2_19829295_ChIP-Seq_ESCs_Human1.46133192
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.45878661
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44071453
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43934307
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43444025
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42873208
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42405867
86TCF4_23295773_ChIP-Seq_U87_Human1.40954143
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40938445
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40924853
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40924853
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40427301
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.39885450
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.39014735
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39014735
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38229575
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38212684
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.37107172
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35764110
98HOXB7_26014856_ChIP-Seq_BT474_Human1.34470942
99* KDM5A_27292631_Chip-Seq_BREAST_Human1.34444607
100* LXR_22292898_ChIP-Seq_THP-1_Human1.34201807
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.33992576
102* DCP1A_22483619_ChIP-Seq_HELA_Human1.33856632
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.33585733
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33577560
105AR_25329375_ChIP-Seq_VCAP_Human1.33552770
106* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32677745
107BCAT_22108803_ChIP-Seq_LS180_Human1.32649483
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32056173
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31748609
110SALL1_21062744_ChIP-ChIP_HESCs_Human1.29766648
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29644410
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29110671
113* SMAD4_21799915_ChIP-Seq_A2780_Human1.29059438
114ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28393183
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28299220
116MYC_18940864_ChIP-ChIP_HL60_Human1.28208062
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27777546
118CBP_20019798_ChIP-Seq_JUKART_Human1.27777546
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27230270
120VDR_23849224_ChIP-Seq_CD4+_Human1.26549699
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26226528
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26195472
123TCF4_22108803_ChIP-Seq_LS180_Human1.25204391
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24761232
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22220701
126REST_21632747_ChIP-Seq_MESCs_Mouse1.21879962
127NCOR_22424771_ChIP-Seq_293T_Human1.21224330
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20588079
129* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19504937
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18704085
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18169129
132ELK1_19687146_ChIP-ChIP_HELA_Human1.17876088
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.17036136
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16365675
135ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15257837
136EGR1_19374776_ChIP-ChIP_THP-1_Human1.15144353
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14127338
138PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13894841
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13770836
140TET1_21451524_ChIP-Seq_MESCs_Mouse1.13219011
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12806838
142FOXP3_21729870_ChIP-Seq_TREG_Human1.11409871
143GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10977918
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10557907
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10269475
146* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.10196720
147FLI1_21867929_ChIP-Seq_TH2_Mouse1.10191321
148* SRF_21415370_ChIP-Seq_HL-1_Mouse1.09740337
149ERG_21242973_ChIP-ChIP_JURKAT_Human1.09574675
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.08582586
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07999814
152FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07784744
153SMAD4_21741376_ChIP-Seq_EPCs_Human1.07538752
154EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07176841
155RARB_24833708_ChIP-Seq_LIVER_Mouse1.06574929
156SMAD3_21741376_ChIP-Seq_EPCs_Human1.06408971
157AR_20517297_ChIP-Seq_VCAP_Human1.06207152
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05729801
159ETS1_21867929_ChIP-Seq_TH2_Mouse1.05724302
160MYC_19829295_ChIP-Seq_ESCs_Human1.05603690
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05157134
162TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05078014
163AR_21909140_ChIP-Seq_LNCAP_Human1.05019852
164TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02916500
165ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00293818
166SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00116859
167TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00009003
168SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99917352
169CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99910220
170RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99700193
171NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99523651
172KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99522704
173CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99013118
174RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98851475
175ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98519445
176YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98095037
177* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97414776
178SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97285690
179GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96295666
180RUNX2_22187159_ChIP-Seq_PCA_Human0.96227685
181* OCT4_20526341_ChIP-Seq_ESCs_Human0.96067896
182RARA_24833708_ChIP-Seq_LIVER_Mouse0.95967311
183TP63_19390658_ChIP-ChIP_HaCaT_Human0.95781626
184ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95482235
185SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94557429
186STAT3_18555785_Chip-Seq_ESCs_Mouse0.93580264
187FOXH1_21741376_ChIP-Seq_ESCs_Human0.92762175
188TAF2_19829295_ChIP-Seq_ESCs_Human0.92319409
189* NANOG_20526341_ChIP-Seq_ESCs_Human0.91994005
190LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91103886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.90026536
2MP0002837_dystrophic_cardiac_calcinosis6.75504948
3MP0003136_yellow_coat_color5.67546151
4MP0010094_abnormal_chromosome_stability3.46471123
5MP0004233_abnormal_muscle_weight3.43204349
6MP0010030_abnormal_orbit_morphology3.33585709
7MP0005171_absent_coat_pigmentation3.28362205
8MP0009278_abnormal_bone_marrow3.28033986
9MP0000569_abnormal_digit_pigmentation3.21248168
10MP0003195_calcinosis3.16760392
11MP0003646_muscle_fatigue3.15618684
12MP0003045_fibrosis2.94642052
13MP0006072_abnormal_retinal_apoptosis2.65698667
14MP0002009_preneoplasia2.60686721
15MP0004957_abnormal_blastocyst_morpholog2.54554278
16MP0008058_abnormal_DNA_repair2.54306758
17MP0003890_abnormal_embryonic-extraembry2.48922549
18MP0003111_abnormal_nucleus_morphology2.43870917
19MP0001545_abnormal_hematopoietic_system2.40999635
20MP0005397_hematopoietic_system_phenotyp2.40999635
21MP0002938_white_spotting2.35186618
22MP0003172_abnormal_lysosome_physiology2.21630557
23MP0005174_abnormal_tail_pigmentation2.20711529
24MP0004147_increased_porphyrin_level2.20215660
25MP0004133_heterotaxia2.07306362
26MP0003077_abnormal_cell_cycle2.04017702
27MP0003786_premature_aging2.03796863
28MP0008995_early_reproductive_senescence1.95881753
29MP0005551_abnormal_eye_electrophysiolog1.93228021
30MP0002102_abnormal_ear_morphology1.92305959
31MP0002396_abnormal_hematopoietic_system1.89994769
32MP0003119_abnormal_digestive_system1.87532590
33MP0001293_anophthalmia1.85853074
34MP0008875_abnormal_xenobiotic_pharmacok1.81365018
35MP0003693_abnormal_embryo_hatching1.81160465
36MP0000490_abnormal_crypts_of1.80242826
37MP0003283_abnormal_digestive_organ1.74289557
38MP0002876_abnormal_thyroid_physiology1.72814615
39MP0004381_abnormal_hair_follicle1.70511225
40MP0009046_muscle_twitch1.68106244
41MP0005075_abnormal_melanosome_morpholog1.66718050
42MP0004043_abnormal_pH_regulation1.65853544
43MP0008932_abnormal_embryonic_tissue1.64208857
44MP0001697_abnormal_embryo_size1.58642524
45MP0005085_abnormal_gallbladder_physiolo1.58605746
46MP0003879_abnormal_hair_cell1.55325875
47MP0002084_abnormal_developmental_patter1.54010696
48MP0000427_abnormal_hair_cycle1.53633406
49MP0000350_abnormal_cell_proliferation1.53627976
50MP0008877_abnormal_DNA_methylation1.52964997
51MP0004197_abnormal_fetal_growth/weight/1.52778856
52MP0002086_abnormal_extraembryonic_tissu1.50168188
53MP0001501_abnormal_sleep_pattern1.47230614
54MP0002249_abnormal_larynx_morphology1.46728565
55MP0003567_abnormal_fetal_cardiomyocyte1.46191854
56MP0001968_abnormal_touch/_nociception1.44402546
57MP0010352_gastrointestinal_tract_polyps1.43584496
58MP0002168_other_aberrant_phenotype1.41588027
59MP0002282_abnormal_trachea_morphology1.41556655
60MP0005076_abnormal_cell_differentiation1.41513541
61MP0002085_abnormal_embryonic_tissue1.40961468
62MP0000372_irregular_coat_pigmentation1.37372603
63MP0002160_abnormal_reproductive_system1.34304690
64MP0000015_abnormal_ear_pigmentation1.34237992
65MP0001672_abnormal_embryogenesis/_devel1.33501123
66MP0005380_embryogenesis_phenotype1.33501123
67MP0002653_abnormal_ependyma_morphology1.32932733
68MP0001986_abnormal_taste_sensitivity1.32218841
69MP0005646_abnormal_pituitary_gland1.31009884
70MP0002095_abnormal_skin_pigmentation1.29705685
71MP0001730_embryonic_growth_arrest1.29405567
72MP0004264_abnormal_extraembryonic_tissu1.25927234
73MP0003656_abnormal_erythrocyte_physiolo1.23848782
74MP0009745_abnormal_behavioral_response1.23787176
75MP0001984_abnormal_olfaction1.23449177
76MP0005389_reproductive_system_phenotype1.22648413
77MP0000371_diluted_coat_color1.21836437
78MP0002272_abnormal_nervous_system1.21729807
79MP0002638_abnormal_pupillary_reflex1.21289419
80MP0002736_abnormal_nociception_after1.17415787
81MP0002019_abnormal_tumor_incidence1.16981144
82MP0002111_abnormal_tail_morphology1.16499440
83MP0008872_abnormal_physiological_respon1.14600188
84MP0002080_prenatal_lethality1.14384811
85MP0008007_abnormal_cellular_replicative1.13017455
86MP0002138_abnormal_hepatobiliary_system1.12668674
87MP0003984_embryonic_growth_retardation1.12237520
88MP0004885_abnormal_endolymph1.11999602
89MP0005253_abnormal_eye_physiology1.10871295
90MP0000685_abnormal_immune_system1.10543042
91MP0001529_abnormal_vocalization1.08284024
92MP0002735_abnormal_chemical_nociception1.08003950
93MP0000383_abnormal_hair_follicle1.07364885
94MP0002088_abnormal_embryonic_growth/wei1.06186342
95MP0003011_delayed_dark_adaptation1.05955360
96MP0005395_other_phenotype1.05690568
97MP0005266_abnormal_metabolism1.04649767
98MP0002932_abnormal_joint_morphology1.03158844
99MP0002075_abnormal_coat/hair_pigmentati1.03075641
100MP0003937_abnormal_limbs/digits/tail_de1.02851117
101MP0000313_abnormal_cell_death1.02662295
102MP0002269_muscular_atrophy1.02354691
103MP0000470_abnormal_stomach_morphology1.01215680
104MP0005058_abnormal_lysosome_morphology1.00433427
105MP0002572_abnormal_emotion/affect_behav0.93933824
106MP0000566_synostosis0.92640720
107MP0003763_abnormal_thymus_physiology0.92583677
108MP0000749_muscle_degeneration0.92548401
109MP0002114_abnormal_axial_skeleton0.92262438
110MP0002064_seizures0.92160030
111MP0001485_abnormal_pinna_reflex0.91111312
112MP0009333_abnormal_splenocyte_physiolog0.87738081
113MP0001486_abnormal_startle_reflex0.87510432
114MP0000689_abnormal_spleen_morphology0.86895599
115MP0006276_abnormal_autonomic_nervous0.86884487
116MP0005379_endocrine/exocrine_gland_phen0.85584589
117MP0003943_abnormal_hepatobiliary_system0.84001220
118MP0003718_maternal_effect0.83353640
119MP0002163_abnormal_gland_morphology0.83306953
120MP0006292_abnormal_olfactory_placode0.83163416
121MP0000049_abnormal_middle_ear0.82553305
122MP0005391_vision/eye_phenotype0.82173416
123MP0001145_abnormal_male_reproductive0.81630843
124MP0001764_abnormal_homeostasis0.80324086
125MP0005332_abnormal_amino_acid0.80157974
126MP0002557_abnormal_social/conspecific_i0.79021500
127MP0002116_abnormal_craniofacial_bone0.78589657
128MP0005220_abnormal_exocrine_pancreas0.77477015
129MP0005195_abnormal_posterior_eye0.77206992
130MP0002405_respiratory_system_inflammati0.76674348
131MP0002229_neurodegeneration0.76648317
132MP0000026_abnormal_inner_ear0.76083791
133MP0000579_abnormal_nail_morphology0.75792453
134MP0000639_abnormal_adrenal_gland0.75024729
135MP0001186_pigmentation_phenotype0.74877237
136MP0002928_abnormal_bile_duct0.74394391
137MP0001324_abnormal_eye_pigmentation0.74271165
138MP0001970_abnormal_pain_threshold0.73406406
139MP0002398_abnormal_bone_marrow0.73115287
140MP0000703_abnormal_thymus_morphology0.72813530
141MP0002751_abnormal_autonomic_nervous0.72276804
142MP0005386_behavior/neurological_phenoty0.71929345
143MP0004924_abnormal_behavior0.71929345
144MP0002752_abnormal_somatic_nervous0.70507212
145MP0002277_abnormal_respiratory_mucosa0.70442253
146MP0002722_abnormal_immune_system0.69959990
147MP0003935_abnormal_craniofacial_develop0.69501302
148MP0001919_abnormal_reproductive_system0.69143209
149MP0000631_abnormal_neuroendocrine_gland0.68857849
150MP0001340_abnormal_eyelid_morphology0.68834540
151MP0002067_abnormal_sensory_capabilities0.68553244
152MP0003453_abnormal_keratinocyte_physiol0.68457120
153MP0000462_abnormal_digestive_system0.68031697
154MP0005410_abnormal_fertilization0.66791967
155MP0003880_abnormal_central_pattern0.66476310
156MP0005365_abnormal_bile_salt0.66416092
157MP0009053_abnormal_anal_canal0.66257431
158MP0009115_abnormal_fat_cell0.66031456
159MP0003137_abnormal_impulse_conducting0.65774103
160MP0004742_abnormal_vestibular_system0.65381417
161MP0005645_abnormal_hypothalamus_physiol0.65192160
162MP0003252_abnormal_bile_duct0.64781932
163MP0002909_abnormal_adrenal_gland0.63601152
164MP0002184_abnormal_innervation0.63475677
165MP0001963_abnormal_hearing_physiology0.63084924
166MP0000432_abnormal_head_morphology0.62885980
167MP0003698_abnormal_male_reproductive0.62536546
168MP0000477_abnormal_intestine_morphology0.61529220
169MP0004142_abnormal_muscle_tone0.61041133
170MP0001929_abnormal_gametogenesis0.61023227
171MP0002210_abnormal_sex_determination0.61005878
172MP0000516_abnormal_urinary_system0.60725721
173MP0005367_renal/urinary_system_phenotyp0.60725721
174MP0000653_abnormal_sex_gland0.60474753
175MP0005670_abnormal_white_adipose0.59666656
176MP0002733_abnormal_thermal_nociception0.55527090
177MP0002063_abnormal_learning/memory/cond0.53454366
178MP0000230_abnormal_systemic_arterial0.51637403

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.90506527
2Rectal fistula (HP:0100590)4.89221827
3Rectovaginal fistula (HP:0000143)4.89221827
4Poikiloderma (HP:0001029)4.83072684
5Hypochromic microcytic anemia (HP:0004840)4.62550314
6Pancreatic cysts (HP:0001737)4.61012392
7Intestinal fistula (HP:0100819)4.46511904
8Vaginal fistula (HP:0004320)4.42305133
9Facial hemangioma (HP:0000329)4.30637493
10Amelogenesis imperfecta (HP:0000705)4.30616603
11Annular pancreas (HP:0001734)4.28387533
12Tongue fasciculations (HP:0001308)4.09558947
13Intestinal atresia (HP:0011100)4.04088656
14Pustule (HP:0200039)3.97676539
15Focal motor seizures (HP:0011153)3.92452796
16Volvulus (HP:0002580)3.91371328
17Concave nail (HP:0001598)3.89908060
18Increased IgM level (HP:0003496)3.79849056
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.74397363
20Abnormality of the renal cortex (HP:0011035)3.70901553
21Nephronophthisis (HP:0000090)3.70576052
22Duplicated collecting system (HP:0000081)3.62896907
23Muscle fibrillation (HP:0010546)3.57221590
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.52271592
25Pancreatic islet-cell hyperplasia (HP:0004510)3.43855679
26Abnormality of the renal medulla (HP:0100957)3.39488922
27Broad alveolar ridges (HP:0000187)3.39371538
28Turricephaly (HP:0000262)3.36445025
29Abnormality of the pons (HP:0007361)3.34834063
30Hypoplasia of the pons (HP:0012110)3.34253591
31Abnormality of the renal collecting system (HP:0004742)3.32817740
32Acute lymphatic leukemia (HP:0006721)3.32753148
33Pancreatic fibrosis (HP:0100732)3.31968870
34Tubular atrophy (HP:0000092)3.28377936
35Congenital stationary night blindness (HP:0007642)3.26593889
36Short humerus (HP:0005792)3.24106483
37Abnormality of male internal genitalia (HP:0000022)3.24097534
38Abnormality of midbrain morphology (HP:0002418)3.23508424
39Molar tooth sign on MRI (HP:0002419)3.23508424
40Ulnar bowing (HP:0003031)3.22335369
41Progressive inability to walk (HP:0002505)3.20061661
42Albinism (HP:0001022)3.17407759
43Aplasia/hypoplasia of the humerus (HP:0006507)3.16033574
44Abnormality of DNA repair (HP:0003254)3.13396555
45Type II lissencephaly (HP:0007260)3.11362246
46Parakeratosis (HP:0001036)3.09028489
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.06244415
48Pendular nystagmus (HP:0012043)3.04797834
49Squamous cell carcinoma (HP:0002860)3.01377858
50Abnormal hemoglobin (HP:0011902)2.99759661
51Selective tooth agenesis (HP:0001592)2.99124255
52Basal cell carcinoma (HP:0002671)2.96404122
53Inability to walk (HP:0002540)2.94438994
54True hermaphroditism (HP:0010459)2.92213732
55Hypochromic anemia (HP:0001931)2.91167892
56Type I transferrin isoform profile (HP:0003642)2.88749953
57Absent thumb (HP:0009777)2.88634530
58Mucopolysacchariduria (HP:0008155)2.85915379
59Urinary glycosaminoglycan excretion (HP:0003541)2.85915379
60Large for gestational age (HP:0001520)2.85445296
61Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.85022604
62Vertebral hypoplasia (HP:0008417)2.85022604
63Orthostatic hypotension (HP:0001278)2.83992775
64Coronal craniosynostosis (HP:0004440)2.83010863
65Anteriorly placed anus (HP:0001545)2.81846855
66Premature graying of hair (HP:0002216)2.81258431
67Alopecia of scalp (HP:0002293)2.80769304
68Attenuation of retinal blood vessels (HP:0007843)2.75536175
69Absent radius (HP:0003974)2.64799828
70Patellar aplasia (HP:0006443)2.62314790
71Joint stiffness (HP:0001387)2.61718081
72Hypotelorism (HP:0000601)2.60663154
73Dysautonomia (HP:0002459)2.57194849
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55689502
75Polydipsia (HP:0001959)2.55484325
76Abnormal drinking behavior (HP:0030082)2.55484325
77Increased number of teeth (HP:0011069)2.51882332
78Cystic liver disease (HP:0006706)2.51579222
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49832529
80Abnormality of polysaccharide metabolism (HP:0011012)2.49832529
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49832529
82Abnormality of the aortic arch (HP:0012303)2.48807509
83Hyperventilation (HP:0002883)2.48303085
84Clubbing of toes (HP:0100760)2.46502564
85Aplasia involving forearm bones (HP:0009822)2.46040117
86Absent forearm bone (HP:0003953)2.46040117
87Muscle fiber atrophy (HP:0100295)2.45977247
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.45952697
89Abnormal protein N-linked glycosylation (HP:0012347)2.45952697
90Abnormal protein glycosylation (HP:0012346)2.45952697
91Abnormal glycosylation (HP:0012345)2.45952697
92Chronic hepatic failure (HP:0100626)2.44192394
93Clumsiness (HP:0002312)2.44119512
94Cerebellar dysplasia (HP:0007033)2.43512595
95Tented upper lip vermilion (HP:0010804)2.41857853
96Abnormal number of incisors (HP:0011064)2.41737615
97Dysostosis multiplex (HP:0000943)2.40655736
98Short chin (HP:0000331)2.39687220
99Aplasia/Hypoplasia of the patella (HP:0006498)2.38724335
100Congenital hip dislocation (HP:0001374)2.37951041
101Abnormality of the anterior horn cell (HP:0006802)2.35912729
102Degeneration of anterior horn cells (HP:0002398)2.35912729
103Male infertility (HP:0003251)2.35794426
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35742787
105Abnormality of alanine metabolism (HP:0010916)2.35742787
106Hyperalaninemia (HP:0003348)2.35742787
107Neoplasm of the oral cavity (HP:0100649)2.35250397
108Meckel diverticulum (HP:0002245)2.33997118
109Dialeptic seizures (HP:0011146)2.32904473
110Methylmalonic acidemia (HP:0002912)2.32871917
111Capillary hemangiomas (HP:0005306)2.32839668
112Alacrima (HP:0000522)2.32040632
113Acanthocytosis (HP:0001927)2.32031387
114Type 2 muscle fiber atrophy (HP:0003554)2.31437481
115Abnormality of endocrine pancreas physiology (HP:0012093)2.30542615
116Abnormality of the pancreatic islet cells (HP:0006476)2.30542615
117Gastrointestinal atresia (HP:0002589)2.29431582
118Hypoproteinemia (HP:0003075)2.26403718
119Increased corneal curvature (HP:0100692)2.25519876
120Keratoconus (HP:0000563)2.25519876
121Growth hormone excess (HP:0000845)2.25118178
122Medial flaring of the eyebrow (HP:0010747)2.24528901
123Bifid uvula (HP:0000193)2.23848086
124Chromsome breakage (HP:0040012)2.22616831
125Aplastic anemia (HP:0001915)2.21618885
126Abolished electroretinogram (ERG) (HP:0000550)2.20413275
127Diaphragmatic weakness (HP:0009113)2.18719321
128Birth length less than 3rd percentile (HP:0003561)2.15707892
129Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14874389
130Severe muscular hypotonia (HP:0006829)2.14779544
131Median cleft lip (HP:0000161)2.11191275
132Hypoplasia of the radius (HP:0002984)2.10709346
133Abnormality of the ileum (HP:0001549)2.10497899
134Polyuria (HP:0000103)2.09606373
135Renal cortical cysts (HP:0000803)2.08732848
136Premature skin wrinkling (HP:0100678)2.08611346
137Popliteal pterygium (HP:0009756)2.08321894
138Narrow nasal bridge (HP:0000446)2.08205594
139Colon cancer (HP:0003003)2.07358465
140Gaze-evoked nystagmus (HP:0000640)2.06152685
141Nephroblastoma (Wilms tumor) (HP:0002667)2.05357362
142Hypoalbuminemia (HP:0003073)2.04594575
143Abnormal albumin level (HP:0012116)2.04594575
144Lissencephaly (HP:0001339)2.04300033
145Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03821082
146Hamartoma (HP:0010566)2.03306860
147Short 5th finger (HP:0009237)2.02163858
148Bowing of the arm (HP:0006488)1.98485584
149Bowed forearm bones (HP:0003956)1.98485584
150Poor head control (HP:0002421)1.96179415
151Broad-based gait (HP:0002136)1.94689975
152IgA deficiency (HP:0002720)1.94505669
153Prolonged QT interval (HP:0001657)1.93791567
154Tubulointerstitial fibrosis (HP:0005576)1.93024700
155Redundant skin (HP:0001582)1.92693477
156Lower limb hyperreflexia (HP:0002395)1.92442893
157Furrowed tongue (HP:0000221)1.92200400
158Abnormal number of erythroid precursors (HP:0012131)1.91692270
159Oligohydramnios (HP:0001562)1.90453836
160Abnormality of the preputium (HP:0100587)1.90376862
161Abnormality of T cell physiology (HP:0011840)1.89514998
162Reduced antithrombin III activity (HP:0001976)1.89510328
163Split hand (HP:0001171)1.89323690
164Aplasia/Hypoplasia of the tibia (HP:0005772)1.87631188
165Vertebral fusion (HP:0002948)1.86936661
166Ketoacidosis (HP:0001993)1.85949899
167Enlarged kidneys (HP:0000105)1.85274396
168Abnormality of chromosome stability (HP:0003220)1.84900006
169Small hand (HP:0200055)1.84785904
170Decreased circulating renin level (HP:0003351)1.84419348
171Retinitis pigmentosa (HP:0000510)1.84095492
172Focal seizures (HP:0007359)1.83612714
173Embryonal renal neoplasm (HP:0011794)1.83146326
174Decreased lacrimation (HP:0000633)1.82347525
1753-Methylglutaconic aciduria (HP:0003535)1.81991331
176Congenital hepatic fibrosis (HP:0002612)1.81943917
177Retinal dysplasia (HP:0007973)1.81047128
178Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.78825346
179Methylmalonic aciduria (HP:0012120)1.78174018
180Spinal muscular atrophy (HP:0007269)1.77833473
181Sclerocornea (HP:0000647)1.77626090
182Myelodysplasia (HP:0002863)1.77309368
183Ulnar claw (HP:0001178)1.76898393
184Stomach cancer (HP:0012126)1.73721732
185Chorioretinal atrophy (HP:0000533)1.73289164
186Anencephaly (HP:0002323)1.73141707
187Tachypnea (HP:0002789)1.72622095
188Brushfield spots (HP:0001088)1.72607703
189Hematochezia (HP:0002573)1.71829490
190Ureteral duplication (HP:0000073)1.70738167
191Abnormality of the carotid arteries (HP:0005344)1.68536194
192Erythroderma (HP:0001019)1.68508101
193Ketosis (HP:0001946)1.67748349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.70093366
2FRK5.25606947
3ICK5.18399927
4STK38L4.81457736
5MAPK154.68846407
6DDR24.31757711
7MAP3K64.14470050
8ZAK3.62296741
9BMPR1B3.45328412
10MAP3K113.35628988
11MATK3.16757082
12ACVR1B3.06834705
13PIM23.04565505
14PINK12.96749113
15DAPK12.68744905
16ADRBK22.40060821
17YES12.29940904
18FGR2.25132348
19WNK42.15716846
20UHMK12.15252831
21CDK72.13706679
22DYRK1B2.06923633
23TYRO32.03757480
24MAP4K21.96193805
25WNK31.88659486
26PRKD21.84341876
27BMX1.80007835
28PRKD31.79410869
29CSK1.79165121
30PIM11.78930171
31GRK11.66992331
32CDC71.64306751
33DYRK31.52510001
34STK381.50083466
35PDGFRA1.48191294
36NLK1.46031298
37CDK61.43255442
38STK31.43086457
39DAPK21.40313802
40TLK11.39213529
41RPS6KL11.38180661
42RPS6KC11.38180661
43ATR1.33984676
44TGFBR11.30785275
45NME11.28448923
46AKT31.27713036
47EIF2AK31.27173562
48RPS6KA61.24768989
49WEE11.24181314
50CHEK21.23642531
51PLK11.20782877
52STK391.20728072
53CDK81.20695498
54MAPK111.11069581
55BUB11.11058594
56MAP2K21.08626007
57NUAK11.08241538
58OXSR11.07826218
59CDC42BPA1.06906958
60TRPM71.05490339
61HIPK21.05202230
62CASK0.99427404
63ADRBK10.99223094
64NEK20.96339574
65INSRR0.95803323
66BRSK20.94549652
67NEK90.92103930
68MAP3K100.91490964
69TNIK0.90630981
70GSK3A0.90126727
71MAPK130.90108422
72CSNK1A1L0.85463773
73BRSK10.83513758
74TAOK10.83068478
75PRKCE0.80740605
76MAP3K40.80493436
77MST40.78679072
78MAP4K10.76141090
79FLT30.75113416
80PLK30.73516144
81CDK20.72787750
82FGFR20.72394139
83RPS6KB10.70783621
84CAMKK20.70745436
85MUSK0.70636922
86TRIM280.69204904
87PHKG10.68942215
88PHKG20.68942215
89TAOK20.67218871
90CSNK2A10.66694538
91TAF10.66625989
92RPS6KB20.66561044
93RAF10.66019997
94CDK120.65693290
95RPS6KA10.65072182
96LYN0.64271058
97PRKCG0.62957873
98SIK10.62731536
99PAK30.61315790
100CHEK10.60895496
101MTOR0.59281297
102AURKA0.58088957
103PRKAA20.56799003
104PRPF4B0.55450912
105ERBB30.54389540
106VRK10.53580378
107PRKAA10.52671992
108NEK10.50640468
109TXK0.50628852
110ATM0.49667188
111PLK20.48245081
112MKNK10.48205819
113CSNK2A20.47723622
114MAPK30.47488094
115PRKCI0.47253723
116BCKDK0.47055942
117MAP2K70.46454186
118TSSK60.45431307
119AURKB0.45160529
120MELK0.44938181
121PASK0.44868461
122GRK70.44382592
123MAPK40.44262514
124CSNK1G20.43011031
125TTK0.42913246
126MKNK20.42902532
127PAK20.42307445
128STK100.41413217
129IKBKB0.41346926
130STK110.41281492
131MARK10.40571457
132CDK40.39977536
133CHUK0.39820498
134CSNK1G30.39234980
135PTK2B0.38788243
136MAPK10.38647586
137PIK3CG0.38585286
138MAPK140.38365881
139CSNK1A10.37845575
140MARK30.37742915
141CSNK1G10.37346768
142CDK10.37256453
143DYRK20.37051114
144MAP2K60.35691007
145TNK20.35656239
146FER0.35445937
147LATS20.34486008
148MAPKAPK20.33487781
149JAK30.33390089
150TIE10.33296097
151CSF1R0.32854244
152EGFR0.32530543
153CAMK1D0.32057785
154RPS6KA50.31753684
155CSNK1D0.31449118
156RPS6KA40.31109121
157MAPK100.30308010
158IKBKE0.28657333
159MAP2K10.28648254
160CAMK2A0.27983847
161PRKACA0.26395289
162PAK40.25987000
163STK160.25835096
164ABL20.25588790
165CDK30.24082128
166BTK0.23897226
167GRK60.22890091
168GSK3B0.22152526
169MAP3K80.21204476
170PRKCQ0.21170714
171PRKCD0.21018453
172PLK40.20655773
173AKT10.19489589
174BRD40.18949551
175TESK20.18662358
176LCK0.17853607
177TAOK30.17171438

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.81060701
2DNA replication_Homo sapiens_hsa030305.55845465
3Base excision repair_Homo sapiens_hsa034105.05297743
4Phototransduction_Homo sapiens_hsa047443.54824726
5Fatty acid biosynthesis_Homo sapiens_hsa000613.27738937
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.21539327
7Nucleotide excision repair_Homo sapiens_hsa034202.95006377
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84488121
9Spliceosome_Homo sapiens_hsa030402.69697380
10Butanoate metabolism_Homo sapiens_hsa006502.62653615
11Homologous recombination_Homo sapiens_hsa034402.62210153
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58305773
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33180682
14RNA transport_Homo sapiens_hsa030132.30883238
15Nicotine addiction_Homo sapiens_hsa050332.28471500
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23882538
17Fanconi anemia pathway_Homo sapiens_hsa034602.21054642
18Cell cycle_Homo sapiens_hsa041102.15346709
19Tryptophan metabolism_Homo sapiens_hsa003802.03173211
20mRNA surveillance pathway_Homo sapiens_hsa030151.99834859
21Sphingolipid metabolism_Homo sapiens_hsa006001.98692540
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95432442
23Nitrogen metabolism_Homo sapiens_hsa009101.87780285
24Linoleic acid metabolism_Homo sapiens_hsa005911.87505226
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.86318191
26Circadian rhythm_Homo sapiens_hsa047101.85874689
27Taste transduction_Homo sapiens_hsa047421.74527241
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70861341
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67072056
30Ribosome_Homo sapiens_hsa030101.63976325
31One carbon pool by folate_Homo sapiens_hsa006701.54740818
32Notch signaling pathway_Homo sapiens_hsa043301.51551020
33Biosynthesis of amino acids_Homo sapiens_hsa012301.50174835
34p53 signaling pathway_Homo sapiens_hsa041151.49532010
35Folate biosynthesis_Homo sapiens_hsa007901.46373373
36Protein export_Homo sapiens_hsa030601.45422624
37Ether lipid metabolism_Homo sapiens_hsa005651.44928615
38Hedgehog signaling pathway_Homo sapiens_hsa043401.44252154
39Oxidative phosphorylation_Homo sapiens_hsa001901.40498275
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37685718
41Propanoate metabolism_Homo sapiens_hsa006401.37015195
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36413338
43Vitamin digestion and absorption_Homo sapiens_hsa049771.35248360
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28842860
45Morphine addiction_Homo sapiens_hsa050321.28676877
46Hippo signaling pathway_Homo sapiens_hsa043901.28662952
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26854495
48ABC transporters_Homo sapiens_hsa020101.25766665
49RNA polymerase_Homo sapiens_hsa030201.23263372
50Arginine and proline metabolism_Homo sapiens_hsa003301.21026207
51Fructose and mannose metabolism_Homo sapiens_hsa000511.18402135
52beta-Alanine metabolism_Homo sapiens_hsa004101.17543430
53Pyrimidine metabolism_Homo sapiens_hsa002401.15232459
54RNA degradation_Homo sapiens_hsa030181.14714966
55mTOR signaling pathway_Homo sapiens_hsa041501.11585838
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08039442
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05279272
58Peroxisome_Homo sapiens_hsa041461.01021461
59TGF-beta signaling pathway_Homo sapiens_hsa043501.00974658
60Histidine metabolism_Homo sapiens_hsa003401.00123342
61Galactose metabolism_Homo sapiens_hsa000520.98788718
62GABAergic synapse_Homo sapiens_hsa047270.98611347
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.96548013
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94975179
65Colorectal cancer_Homo sapiens_hsa052100.94807543
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94043957
67Sulfur metabolism_Homo sapiens_hsa009200.93584006
68Glycerolipid metabolism_Homo sapiens_hsa005610.93568850
69Wnt signaling pathway_Homo sapiens_hsa043100.93382677
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93335348
71Vitamin B6 metabolism_Homo sapiens_hsa007500.93146120
72Collecting duct acid secretion_Homo sapiens_hsa049660.92575501
73N-Glycan biosynthesis_Homo sapiens_hsa005100.91671476
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91179056
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90711984
76Non-homologous end-joining_Homo sapiens_hsa034500.86925209
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85774367
78Fatty acid elongation_Homo sapiens_hsa000620.85308646
79Primary immunodeficiency_Homo sapiens_hsa053400.85098430
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.82978773
81Steroid biosynthesis_Homo sapiens_hsa001000.82402313
82Oocyte meiosis_Homo sapiens_hsa041140.81690977
83Lysine degradation_Homo sapiens_hsa003100.80781931
84Basal transcription factors_Homo sapiens_hsa030220.80601412
85Dorso-ventral axis formation_Homo sapiens_hsa043200.80531164
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.80404606
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80368365
88Sulfur relay system_Homo sapiens_hsa041220.79936950
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79571178
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78635746
91Ovarian steroidogenesis_Homo sapiens_hsa049130.78039873
92Olfactory transduction_Homo sapiens_hsa047400.77299696
93Adherens junction_Homo sapiens_hsa045200.75865491
94Parkinsons disease_Homo sapiens_hsa050120.75862057
95Thyroid cancer_Homo sapiens_hsa052160.75278385
96Basal cell carcinoma_Homo sapiens_hsa052170.74134893
97Caffeine metabolism_Homo sapiens_hsa002320.71382311
98Acute myeloid leukemia_Homo sapiens_hsa052210.70636849
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.70399786
100Bladder cancer_Homo sapiens_hsa052190.70200287
101Serotonergic synapse_Homo sapiens_hsa047260.68453220
102Calcium signaling pathway_Homo sapiens_hsa040200.66528595
103Huntingtons disease_Homo sapiens_hsa050160.65983603
104Fatty acid degradation_Homo sapiens_hsa000710.65579810
105Glutamatergic synapse_Homo sapiens_hsa047240.65563914
106Insulin secretion_Homo sapiens_hsa049110.64254854
107Shigellosis_Homo sapiens_hsa051310.63637549
108Viral carcinogenesis_Homo sapiens_hsa052030.59825489
109Herpes simplex infection_Homo sapiens_hsa051680.59793625
110Chemical carcinogenesis_Homo sapiens_hsa052040.57968741
111Arachidonic acid metabolism_Homo sapiens_hsa005900.57624187
112Fatty acid metabolism_Homo sapiens_hsa012120.57007393
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.56952588
114Legionellosis_Homo sapiens_hsa051340.56123344
115Proteasome_Homo sapiens_hsa030500.55675754
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55464801
117Chronic myeloid leukemia_Homo sapiens_hsa052200.55372200
118Pyruvate metabolism_Homo sapiens_hsa006200.54729049
119Retinol metabolism_Homo sapiens_hsa008300.52474841
120MicroRNAs in cancer_Homo sapiens_hsa052060.52396204
121VEGF signaling pathway_Homo sapiens_hsa043700.51808779
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.51602907
123Circadian entrainment_Homo sapiens_hsa047130.50833220
124Epstein-Barr virus infection_Homo sapiens_hsa051690.50382300
125Small cell lung cancer_Homo sapiens_hsa052220.48289703
126HTLV-I infection_Homo sapiens_hsa051660.47047478
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46461449
128Selenocompound metabolism_Homo sapiens_hsa004500.43807396
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43789892
130Purine metabolism_Homo sapiens_hsa002300.42424425
131Glutathione metabolism_Homo sapiens_hsa004800.42277626
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.40700106
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40651584
134Regulation of autophagy_Homo sapiens_hsa041400.37525425
135Fat digestion and absorption_Homo sapiens_hsa049750.37141724
136B cell receptor signaling pathway_Homo sapiens_hsa046620.34763916
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34430012
138Hepatitis B_Homo sapiens_hsa051610.33024413
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.32707452
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31419579
141Pentose phosphate pathway_Homo sapiens_hsa000300.31211094
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30699080
143Salivary secretion_Homo sapiens_hsa049700.26710715
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25798884
145AMPK signaling pathway_Homo sapiens_hsa041520.25154955
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24039671
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23807203
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22443104
149Endometrial cancer_Homo sapiens_hsa052130.22017560
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18632769
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15117059
152Pathways in cancer_Homo sapiens_hsa052000.14892771
153Gap junction_Homo sapiens_hsa045400.14756818
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13882142
155PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13308018
156Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12315250
157Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12086579
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11349316
159Viral myocarditis_Homo sapiens_hsa054160.11239428
160Insulin signaling pathway_Homo sapiens_hsa049100.11111546
161Metabolic pathways_Homo sapiens_hsa011000.09510319
162HIF-1 signaling pathway_Homo sapiens_hsa040660.09415251
163Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.08760307

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