ZSCAN21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.49671288
2behavioral response to nicotine (GO:0035095)5.12236619
3glycine transport (GO:0015816)4.84053982
4protein prenylation (GO:0018342)4.57425466
5prenylation (GO:0097354)4.57425466
6DNA double-strand break processing (GO:0000729)4.53371607
7gamma-aminobutyric acid transport (GO:0015812)4.35885898
8negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.24486507
9negative regulation of DNA-templated transcription, elongation (GO:0032785)4.24486507
10histone H2A acetylation (GO:0043968)4.20102171
11axonal fasciculation (GO:0007413)4.02670855
12piRNA metabolic process (GO:0034587)3.96171174
13microtubule depolymerization (GO:0007019)3.90276672
14positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77911666
15positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77911666
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.77911666
17pyrimidine nucleobase catabolic process (GO:0006208)3.69479027
18protein-DNA complex disassembly (GO:0032986)3.63840625
19nucleosome disassembly (GO:0006337)3.63840625
20protein-cofactor linkage (GO:0018065)3.61542327
21paraxial mesoderm development (GO:0048339)3.57434785
22urogenital system development (GO:0001655)3.50842093
23peptidyl-arginine omega-N-methylation (GO:0035247)3.47550783
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.45702448
25prepulse inhibition (GO:0060134)3.43395735
26DNA unwinding involved in DNA replication (GO:0006268)3.35707237
27cullin deneddylation (GO:0010388)3.32772227
28binding of sperm to zona pellucida (GO:0007339)3.31799371
29protein deneddylation (GO:0000338)3.30603915
30regulation of sister chromatid cohesion (GO:0007063)3.27670719
31outer ear morphogenesis (GO:0042473)3.25232223
32cilium or flagellum-dependent cell motility (GO:0001539)3.23684546
33regulation of cilium movement (GO:0003352)3.23108993
34DNA strand elongation involved in DNA replication (GO:0006271)3.22738887
35negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21211827
36negative regulation of sister chromatid segregation (GO:0033046)3.21211827
37negative regulation of mitotic sister chromatid separation (GO:2000816)3.21211827
38negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21211827
39monoubiquitinated protein deubiquitination (GO:0035520)3.20031876
40peptidyl-arginine methylation (GO:0018216)3.19746746
41peptidyl-arginine N-methylation (GO:0035246)3.19746746
42regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.18799987
43histone arginine methylation (GO:0034969)3.18387785
44mitotic spindle assembly checkpoint (GO:0007094)3.18309736
45negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15712051
46nonmotile primary cilium assembly (GO:0035058)3.15537238
47negative regulation of chromosome segregation (GO:0051985)3.15128796
48protein K11-linked ubiquitination (GO:0070979)3.14621933
49spliceosomal snRNP assembly (GO:0000387)3.13291820
50chromatin remodeling at centromere (GO:0031055)3.12951269
51DNA strand elongation (GO:0022616)3.12134882
52kinetochore assembly (GO:0051382)3.10741714
53DNA replication initiation (GO:0006270)3.10692187
54spindle assembly checkpoint (GO:0071173)3.10062347
55DNA integration (GO:0015074)3.09860606
56viral mRNA export from host cell nucleus (GO:0046784)3.09645133
57proteasome assembly (GO:0043248)3.09539791
58mitotic metaphase plate congression (GO:0007080)3.09474701
59postreplication repair (GO:0006301)3.07666847
60sperm-egg recognition (GO:0035036)3.07077101
61DNA methylation involved in gamete generation (GO:0043046)3.04564949
62neuron recognition (GO:0008038)3.04058477
63protein localization to kinetochore (GO:0034501)3.03691370
64RNA localization (GO:0006403)3.03143488
65platelet dense granule organization (GO:0060155)3.02392822
66kinetochore organization (GO:0051383)3.00536244
67attachment of spindle microtubules to kinetochore (GO:0008608)3.00497232
68DNA replication-dependent nucleosome assembly (GO:0006335)2.98309481
69DNA replication-dependent nucleosome organization (GO:0034723)2.98309481
70mechanosensory behavior (GO:0007638)2.96767036
71oxidative demethylation (GO:0070989)2.93505841
72mitotic spindle checkpoint (GO:0071174)2.92169245
73maturation of SSU-rRNA (GO:0030490)2.92076191
74translesion synthesis (GO:0019985)2.91375764
75melanosome transport (GO:0032402)2.90627819
76intraciliary transport (GO:0042073)2.89785067
77establishment of melanosome localization (GO:0032401)2.88739100
78purine nucleobase biosynthetic process (GO:0009113)2.87884352
79formation of translation preinitiation complex (GO:0001731)2.87671466
80termination of RNA polymerase III transcription (GO:0006386)2.86469326
81transcription elongation from RNA polymerase III promoter (GO:0006385)2.86469326
82spindle checkpoint (GO:0031577)2.85945266
83metallo-sulfur cluster assembly (GO:0031163)2.84792830
84iron-sulfur cluster assembly (GO:0016226)2.84792830
85protein localization to chromosome, centromeric region (GO:0071459)2.83159830
86synaptonemal complex organization (GO:0070193)2.82367087
87intra-S DNA damage checkpoint (GO:0031573)2.81976227
88synaptonemal complex assembly (GO:0007130)2.81712720
89cellular response to leptin stimulus (GO:0044320)2.81328516
90recombinational repair (GO:0000725)2.80787152
91non-recombinational repair (GO:0000726)2.79366644
92double-strand break repair via nonhomologous end joining (GO:0006303)2.79366644
93epithelial cilium movement (GO:0003351)2.79014014
94pigment granule transport (GO:0051904)2.77671911
95male meiosis (GO:0007140)2.76959319
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76951906
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.76951906
98regulation of chromosome segregation (GO:0051983)2.76783696
99establishment of pigment granule localization (GO:0051905)2.76428611
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75403210
101negative regulation of mitosis (GO:0045839)2.75059645
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74060805
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73970089
104protein targeting to lysosome (GO:0006622)2.73856829
105establishment of protein localization to vacuole (GO:0072666)2.73856829
106protein targeting to vacuole (GO:0006623)2.73856829
107spliceosomal complex assembly (GO:0000245)2.73680918
108ionotropic glutamate receptor signaling pathway (GO:0035235)2.73655485
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.72194488
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71859998
111single strand break repair (GO:0000012)2.71824099
112protein K6-linked ubiquitination (GO:0085020)2.71272796
113negative regulation of proteasomal protein catabolic process (GO:1901799)2.71216395
114melanosome localization (GO:0032400)2.70171178
115meiotic chromosome segregation (GO:0045132)2.69421060
116nucleobase biosynthetic process (GO:0046112)2.69416595
117regulation of sister chromatid segregation (GO:0033045)2.69407007
118regulation of mitotic sister chromatid separation (GO:0010965)2.69407007
119regulation of mitotic sister chromatid segregation (GO:0033047)2.69407007
120negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.67742262
121resolution of meiotic recombination intermediates (GO:0000712)2.67693944
122regulation of meiosis I (GO:0060631)2.67535853
123retinal rod cell development (GO:0046548)2.66637128
124positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65983433
125DNA replication checkpoint (GO:0000076)2.65478369
126telomere maintenance via semi-conservative replication (GO:0032201)2.65162307
127snRNA processing (GO:0016180)2.65029714
128double-strand break repair via homologous recombination (GO:0000724)2.64662188
129metaphase plate congression (GO:0051310)2.64298530
130anterograde synaptic vesicle transport (GO:0048490)2.63725379
131negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63226894
132sperm motility (GO:0030317)2.61849791
133L-fucose catabolic process (GO:0042355)2.61344108
134fucose catabolic process (GO:0019317)2.61344108
135L-fucose metabolic process (GO:0042354)2.61344108
136positive regulation of chromosome segregation (GO:0051984)2.60628159
137spliceosomal tri-snRNP complex assembly (GO:0000244)2.59914128
138de novo posttranslational protein folding (GO:0051084)2.59660936
139pigment granule localization (GO:0051875)2.59588245
140regulation of centriole replication (GO:0046599)2.58232886
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.58050739
142replication fork processing (GO:0031297)2.57489422
143CENP-A containing nucleosome assembly (GO:0034080)2.57474238
144short-term memory (GO:0007614)2.57161038
145negative regulation of response to food (GO:0032096)2.56149138
146negative regulation of appetite (GO:0032099)2.56149138
147nucleobase catabolic process (GO:0046113)2.55250384
148RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54670962
149ATP-dependent chromatin remodeling (GO:0043044)2.54658120
150gene silencing by RNA (GO:0031047)2.53971394
151auditory behavior (GO:0031223)2.53754822
152negative regulation of nuclear division (GO:0051784)2.53611955
153cell proliferation in forebrain (GO:0021846)2.53410612
154inositol phosphate catabolic process (GO:0071545)2.53004207
155mRNA splicing, via spliceosome (GO:0000398)2.52889731
156RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.52889731
157DNA damage response, detection of DNA damage (GO:0042769)2.52369739
158negative regulation of mRNA processing (GO:0050686)2.51877922
159regulation of development, heterochronic (GO:0040034)2.51686680
160cell-cell recognition (GO:0009988)2.51281059
161water-soluble vitamin biosynthetic process (GO:0042364)2.50752289
162dosage compensation (GO:0007549)2.50641044
163RNA splicing, via transesterification reactions (GO:0000375)2.50000537
164negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49711080
165negative regulation of ligase activity (GO:0051352)2.49711080
166histone mRNA metabolic process (GO:0008334)2.48785317
167negative regulation of proteolysis involved in cellular protein catabolic process (GO:1903051)2.48782216
168brain morphogenesis (GO:0048854)2.48254388
169histone exchange (GO:0043486)2.48073834
170DNA demethylation (GO:0080111)2.47454234
171protein sumoylation (GO:0016925)2.47389665
172seminiferous tubule development (GO:0072520)2.45096644
173mitochondrial RNA metabolic process (GO:0000959)2.42706572
174respiratory chain complex IV assembly (GO:0008535)2.42673657
175negative regulation of DNA-dependent DNA replication (GO:2000104)2.41799890
176exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.41567009
177inositol phosphate dephosphorylation (GO:0046855)2.41222688
178phosphorylated carbohydrate dephosphorylation (GO:0046838)2.41222688
179ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.39685709
180nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39498004
181transmission of nerve impulse (GO:0019226)2.38194768
182acrosome assembly (GO:0001675)2.37713545
183DNA catabolic process, exonucleolytic (GO:0000738)2.37234571
184regulation of double-strand break repair via homologous recombination (GO:0010569)2.36400473
185dendrite development (GO:0016358)2.34002420
186retinal ganglion cell axon guidance (GO:0031290)2.33204602
187regulation of mRNA splicing, via spliceosome (GO:0048024)2.30775480
188protein import into peroxisome matrix (GO:0016558)2.30437508
1897-methylguanosine mRNA capping (GO:0006370)2.30207310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14457478
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.82392796
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.83086613
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.74262192
5VDR_22108803_ChIP-Seq_LS180_Human3.54117049
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.43360613
7IGF1R_20145208_ChIP-Seq_DFB_Human3.39012062
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09095274
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.07691884
10ZNF274_21170338_ChIP-Seq_K562_Hela3.00884671
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95056103
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.93636224
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82659753
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76568782
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72718174
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.70621740
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55109266
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.51199160
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.38383481
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36940981
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35852444
22* XRN2_22483619_ChIP-Seq_HELA_Human2.35360976
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34329714
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34128513
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.33704862
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18643618
27GBX2_23144817_ChIP-Seq_PC3_Human2.16196263
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14153937
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11029168
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10516617
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.08230116
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.06228493
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05778359
34EWS_26573619_Chip-Seq_HEK293_Human2.04832087
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03497095
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02906162
37THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02229307
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98285389
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.94697387
40GABP_19822575_ChIP-Seq_HepG2_Human1.94252747
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93783381
42* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90741683
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87589655
44TTF2_22483619_ChIP-Seq_HELA_Human1.81025472
45FUS_26573619_Chip-Seq_HEK293_Human1.79407892
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78678366
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78465933
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74173517
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72168448
50DCP1A_22483619_ChIP-Seq_HELA_Human1.68635880
51AR_21909140_ChIP-Seq_LNCAP_Human1.67568760
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67431003
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66669740
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66632914
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.66229374
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.65532439
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65062091
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64069348
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63398136
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62423376
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59526997
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59143970
63CIITA_25753668_ChIP-Seq_RAJI_Human1.55749281
64VDR_23849224_ChIP-Seq_CD4+_Human1.54168987
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54119379
66P300_19829295_ChIP-Seq_ESCs_Human1.51759436
67FOXP3_21729870_ChIP-Seq_TREG_Human1.51637617
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50826572
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50506922
70* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49873997
71* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49703597
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48390139
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45792415
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45792415
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40583998
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39697807
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.39247073
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39070185
79TAF15_26573619_Chip-Seq_HEK293_Human1.38802581
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36965316
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.34187093
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32003030
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.31828931
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27351325
85TP53_22573176_ChIP-Seq_HFKS_Human1.26552219
86* SRF_21415370_ChIP-Seq_HL-1_Mouse1.25894946
87EZH2_22144423_ChIP-Seq_EOC_Human1.25016556
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24631850
89CBP_20019798_ChIP-Seq_JUKART_Human1.24631850
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23372915
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21266557
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20613557
93ELK1_19687146_ChIP-ChIP_HELA_Human1.17714875
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17128785
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16628589
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15796989
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15180304
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14811208
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.12828574
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11667491
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.11084593
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10512737
103RNF2_27304074_Chip-Seq_NSC_Mouse1.06942975
104KDM5A_27292631_Chip-Seq_BREAST_Human1.05831492
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05395070
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03507700
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02866877
108* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00522920
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00254859
110REST_21632747_ChIP-Seq_MESCs_Mouse1.00063672
111BCAT_22108803_ChIP-Seq_LS180_Human1.00032344
112SMAD4_21799915_ChIP-Seq_A2780_Human0.98827471
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.98251358
114GATA1_26923725_Chip-Seq_HPCs_Mouse0.98106145
115MYC_18940864_ChIP-ChIP_HL60_Human0.97688420
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97552925
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97094410
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96948127
119HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96862740
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96686930
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96172451
122ER_23166858_ChIP-Seq_MCF-7_Human0.95784350
123EZH2_27304074_Chip-Seq_ESCs_Mouse0.95370655
124STAT3_23295773_ChIP-Seq_U87_Human0.94952799
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92358719
126TCF4_22108803_ChIP-Seq_LS180_Human0.92338848
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92283702
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92009395
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91186667
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90814850
131* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89369754
132PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89188165
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88978141
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88840563
135* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88557521
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87585889
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85065459
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84803711
139NANOG_16153702_ChIP-ChIP_HESCs_Human0.84587521
140TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81632624
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79443268
142BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76761412
143POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.76666234
144SOX17_20123909_ChIP-Seq_XEN_Mouse0.76387436
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.75910120
146IRF1_19129219_ChIP-ChIP_H3396_Human0.75868269
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.74671529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.09981423
2MP0010030_abnormal_orbit_morphology3.05527319
3MP0003122_maternal_imprinting2.96034879
4MP0000537_abnormal_urethra_morphology2.94935503
5MP0003121_genomic_imprinting2.88965903
6MP0008058_abnormal_DNA_repair2.60566823
7MP0003077_abnormal_cell_cycle2.57000913
8MP0003123_paternal_imprinting2.50021525
9MP0003315_abnormal_perineum_morphology2.42952555
10MP0010094_abnormal_chromosome_stability2.42277943
11MP0002653_abnormal_ependyma_morphology2.38553511
12MP0003942_abnormal_urinary_system2.37466167
13MP0006292_abnormal_olfactory_placode2.25225186
14MP0008877_abnormal_DNA_methylation2.24932526
15MP0003111_abnormal_nucleus_morphology2.24684569
16MP0008007_abnormal_cellular_replicative2.23923114
17MP0002282_abnormal_trachea_morphology2.21683618
18MP0008995_early_reproductive_senescence2.19713973
19MP0002249_abnormal_larynx_morphology2.17126659
20MP0008057_abnormal_DNA_replication2.16289622
21MP0002102_abnormal_ear_morphology2.09653039
22MP0008932_abnormal_embryonic_tissue2.07910337
23MP0000534_abnormal_ureter_morphology2.04464275
24MP0000049_abnormal_middle_ear2.03624666
25MP0001529_abnormal_vocalization1.95176880
26MP0003136_yellow_coat_color1.93151793
27MP0004957_abnormal_blastocyst_morpholog1.92187770
28MP0001984_abnormal_olfaction1.91967763
29MP0003385_abnormal_body_wall1.89386461
30MP0003890_abnormal_embryonic-extraembry1.88479066
31MP0000013_abnormal_adipose_tissue1.85171697
32MP0005551_abnormal_eye_electrophysiolog1.84799750
33MP0008789_abnormal_olfactory_epithelium1.83024509
34MP0002210_abnormal_sex_determination1.82456448
35MP0000778_abnormal_nervous_system1.81884867
36MP0005410_abnormal_fertilization1.78730341
37MP0002938_white_spotting1.76480167
38MP0004142_abnormal_muscle_tone1.71974973
39MP0001929_abnormal_gametogenesis1.67026998
40MP0003786_premature_aging1.60652294
41MP0003698_abnormal_male_reproductive1.53782226
42MP0001730_embryonic_growth_arrest1.52625052
43MP0001293_anophthalmia1.49456316
44MP0003937_abnormal_limbs/digits/tail_de1.49126708
45MP0006276_abnormal_autonomic_nervous1.48464078
46MP0003119_abnormal_digestive_system1.47454473
47MP0003787_abnormal_imprinting1.44355504
48MP0002272_abnormal_nervous_system1.44204180
49MP0002085_abnormal_embryonic_tissue1.43614745
50MP0002234_abnormal_pharynx_morphology1.41966736
51MP0009053_abnormal_anal_canal1.41204237
52MP0003861_abnormal_nervous_system1.40504537
53MP0002751_abnormal_autonomic_nervous1.39345398
54MP0003755_abnormal_palate_morphology1.38821832
55MP0010386_abnormal_urinary_bladder1.38103598
56MP0003878_abnormal_ear_physiology1.37383191
57MP0005377_hearing/vestibular/ear_phenot1.37383191
58MP0000372_irregular_coat_pigmentation1.34703562
59MP0001697_abnormal_embryo_size1.34544259
60MP0003567_abnormal_fetal_cardiomyocyte1.34138836
61MP0005394_taste/olfaction_phenotype1.33215609
62MP0005499_abnormal_olfactory_system1.33215609
63MP0001145_abnormal_male_reproductive1.31776293
64MP0004859_abnormal_synaptic_plasticity1.28582729
65MP0004133_heterotaxia1.28165704
66MP0002084_abnormal_developmental_patter1.28025603
67MP0000653_abnormal_sex_gland1.26323609
68MP0000678_abnormal_parathyroid_gland1.25799646
69MP0001672_abnormal_embryogenesis/_devel1.25725184
70MP0005380_embryogenesis_phenotype1.25725184
71MP0000350_abnormal_cell_proliferation1.25585429
72MP0009250_abnormal_appendicular_skeleto1.22716295
73MP0003115_abnormal_respiratory_system1.21348074
74MP0001324_abnormal_eye_pigmentation1.20197458
75MP0001286_abnormal_eye_development1.19630283
76MP0002736_abnormal_nociception_after1.18739205
77MP0008260_abnormal_autophagy1.18463837
78MP0003935_abnormal_craniofacial_develop1.16087940
79MP0000631_abnormal_neuroendocrine_gland1.14938542
80MP0002932_abnormal_joint_morphology1.14861663
81MP0005423_abnormal_somatic_nervous1.12557977
82MP0004885_abnormal_endolymph1.10352078
83MP0003984_embryonic_growth_retardation1.08797253
84MP0000516_abnormal_urinary_system1.08500604
85MP0005367_renal/urinary_system_phenotyp1.08500604
86MP0002161_abnormal_fertility/fecundity1.08487350
87MP0002088_abnormal_embryonic_growth/wei1.07075285
88MP0002752_abnormal_somatic_nervous1.05510690
89MP0003718_maternal_effect1.05136425
90MP0008872_abnormal_physiological_respon1.04377774
91MP0002233_abnormal_nose_morphology1.03778949
92MP0005084_abnormal_gallbladder_morpholo1.03707999
93MP0005187_abnormal_penis_morphology1.02268399
94MP0004197_abnormal_fetal_growth/weight/1.00410322
95MP0003938_abnormal_ear_development1.00322100
96MP0000569_abnormal_digit_pigmentation1.00149470
97MP0001968_abnormal_touch/_nociception1.00117134
98MP0002116_abnormal_craniofacial_bone0.99805046
99MP0004134_abnormal_chest_morphology0.99667201
100MP0002638_abnormal_pupillary_reflex0.98227966
101MP0002080_prenatal_lethality0.96781560
102MP0002177_abnormal_outer_ear0.96751185
103MP0000566_synostosis0.95903398
104MP0003635_abnormal_synaptic_transmissio0.95863170
105MP0001119_abnormal_female_reproductive0.95413142
106MP0005257_abnormal_intraocular_pressure0.93354899
107MP0009697_abnormal_copulation0.92901567
108MP0002111_abnormal_tail_morphology0.92860438
109MP0002734_abnormal_mechanical_nocicepti0.92843086
110MP0005253_abnormal_eye_physiology0.92578404
111MP0001986_abnormal_taste_sensitivity0.91868582
112MP0002557_abnormal_social/conspecific_i0.91354328
113MP0005195_abnormal_posterior_eye0.90571866
114MP0002114_abnormal_axial_skeleton0.90357412
115MP0002081_perinatal_lethality0.89617616
116MP0002160_abnormal_reproductive_system0.89538681
117MP0004811_abnormal_neuron_physiology0.88665590
118MP0001188_hyperpigmentation0.88355539
119MP0002127_abnormal_cardiovascular_syste0.87964893
120MP0001270_distended_abdomen0.87501754
121MP0002184_abnormal_innervation0.86721542
122MP0003880_abnormal_central_pattern0.85998898
123MP0002882_abnormal_neuron_morphology0.85834440
124MP0001485_abnormal_pinna_reflex0.85655963
125MP0000647_abnormal_sebaceous_gland0.85034942
126MP0000026_abnormal_inner_ear0.84039660
127MP0008775_abnormal_heart_ventricle0.83635856
128MP0002092_abnormal_eye_morphology0.83590435
129MP0000428_abnormal_craniofacial_morphol0.82369656
130MP0002837_dystrophic_cardiac_calcinosis0.81809435
131MP0009672_abnormal_birth_weight0.80007099
132MP0006035_abnormal_mitochondrial_morpho0.79872589
133MP0003221_abnormal_cardiomyocyte_apopto0.79585872
134MP0004233_abnormal_muscle_weight0.78315732
135MP0009745_abnormal_behavioral_response0.78091105
136MP0002095_abnormal_skin_pigmentation0.77520938
137MP0001919_abnormal_reproductive_system0.77082266
138MP0002090_abnormal_vision0.76864216
139MP0000432_abnormal_head_morphology0.76380761
140MP0005391_vision/eye_phenotype0.76202211
141MP0002697_abnormal_eye_size0.74955188
142MP0005076_abnormal_cell_differentiation0.73354385
143MP0000538_abnormal_urinary_bladder0.73282231
144MP0002152_abnormal_brain_morphology0.71160716

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.41020408
2Impulsivity (HP:0100710)4.21991241
3Gait imbalance (HP:0002141)4.18703031
4Breast hypoplasia (HP:0003187)4.09426689
5Nephrogenic diabetes insipidus (HP:0009806)4.06690584
6Congenital primary aphakia (HP:0007707)4.05483730
7Medial flaring of the eyebrow (HP:0010747)4.04612533
8Genital tract atresia (HP:0001827)3.75645567
9Vaginal atresia (HP:0000148)3.75496455
10Degeneration of anterior horn cells (HP:0002398)3.60895406
11Abnormality of the anterior horn cell (HP:0006802)3.60895406
12High anterior hairline (HP:0009890)3.57432911
13Ependymoma (HP:0002888)3.50946050
14Birth length less than 3rd percentile (HP:0003561)3.40781789
15Patellar aplasia (HP:0006443)3.32670823
16Abnormality of the labia minora (HP:0012880)3.16843517
17Aplasia/Hypoplasia of the patella (HP:0006498)3.11953682
18Optic nerve hypoplasia (HP:0000609)3.09075568
19Increased hepatocellular lipid droplets (HP:0006565)3.04627916
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.00400759
21Short 4th metacarpal (HP:0010044)3.00400759
22Colon cancer (HP:0003003)2.99605753
23Poor coordination (HP:0002370)2.97022010
24Absent septum pellucidum (HP:0001331)2.95769179
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.86524585
26Shawl scrotum (HP:0000049)2.76165168
27Astrocytoma (HP:0009592)2.74946692
28Abnormality of the astrocytes (HP:0100707)2.74946692
29Lipid accumulation in hepatocytes (HP:0006561)2.70153294
30Chronic hepatic failure (HP:0100626)2.69782844
31Midline defect of the nose (HP:0004122)2.67778696
32Humeroradial synostosis (HP:0003041)2.66834435
33Synostosis involving the elbow (HP:0003938)2.66834435
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.60947002
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.59896450
36Broad foot (HP:0001769)2.57436474
37Renal duplication (HP:0000075)2.57277171
38Optic nerve coloboma (HP:0000588)2.53348783
39Abnormality of the septum pellucidum (HP:0007375)2.52969627
40Aqueductal stenosis (HP:0002410)2.49996001
41Cortical dysplasia (HP:0002539)2.42913366
42Medulloblastoma (HP:0002885)2.42538765
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.42536175
44Absent/shortened dynein arms (HP:0200106)2.42536175
45Hypoplastic pelvis (HP:0008839)2.42354619
46Decreased testicular size (HP:0008734)2.40431666
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.37388277
48Renal Fanconi syndrome (HP:0001994)2.36063626
49Selective tooth agenesis (HP:0001592)2.35102296
50Meckel diverticulum (HP:0002245)2.34754588
51Facial cleft (HP:0002006)2.33716652
52Embryonal renal neoplasm (HP:0011794)2.33277407
53Supernumerary spleens (HP:0009799)2.32797104
54Nephroblastoma (Wilms tumor) (HP:0002667)2.28392867
55Abnormality of the 4th metacarpal (HP:0010012)2.28254467
56Nephronophthisis (HP:0000090)2.27313616
57Abnormality of the intervertebral disk (HP:0005108)2.26380009
58Hepatoblastoma (HP:0002884)2.25647999
59Shoulder girdle muscle weakness (HP:0003547)2.25437704
60Wrist flexion contracture (HP:0001239)2.22742500
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21482973
62Abnormal biliary tract physiology (HP:0012439)2.20378949
63Bile duct proliferation (HP:0001408)2.20378949
64Microglossia (HP:0000171)2.19877825
65Abnormal hair whorl (HP:0010721)2.19257519
66Abnormality of the ileum (HP:0001549)2.18417010
67True hermaphroditism (HP:0010459)2.18259665
68Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.16852827
69Carpal bone hypoplasia (HP:0001498)2.14522020
70Glioma (HP:0009733)2.13724198
71Tongue fasciculations (HP:0001308)2.11239893
72Bifid tongue (HP:0010297)2.09474330
73Micropenis (HP:0000054)2.09234039
74Aplasia/Hypoplasia of the sternum (HP:0006714)2.08616221
75Abnormality of midbrain morphology (HP:0002418)2.06048990
76Molar tooth sign on MRI (HP:0002419)2.06048990
77Atresia of the external auditory canal (HP:0000413)2.04597601
78Tubular atrophy (HP:0000092)2.04325431
79Choanal stenosis (HP:0000452)2.03859172
80Lymphangioma (HP:0100764)2.02822509
81Atrophy/Degeneration involving motor neurons (HP:0007373)2.02767350
82Specific learning disability (HP:0001328)2.02747556
83Intestinal atresia (HP:0011100)2.01984805
84Postaxial hand polydactyly (HP:0001162)2.00724840
85Pancreatic fibrosis (HP:0100732)1.99429368
86Abnormal respiratory epithelium morphology (HP:0012253)1.99360236
87Abnormal respiratory motile cilium morphology (HP:0005938)1.99360236
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.98853725
89Hypoplasia of the fovea (HP:0007750)1.98853725
90Chorioretinal coloboma (HP:0000567)1.95792641
91Astigmatism (HP:0000483)1.95443242
92Pendular nystagmus (HP:0012043)1.94829471
93Multicystic kidney dysplasia (HP:0000003)1.94285269
94Abnormal pancreas size (HP:0012094)1.93460981
95Aplasia/Hypoplasia of the lens (HP:0008063)1.92744190
96Type II lissencephaly (HP:0007260)1.92103440
97Pancreatic cysts (HP:0001737)1.91170216
98Abnormality of the phalanges of the hallux (HP:0010057)1.90310716
99Retinitis pigmentosa (HP:0000510)1.90307564
100Decreased muscle mass (HP:0003199)1.88735494
101Polymicrogyria (HP:0002126)1.88505317
102Papillary thyroid carcinoma (HP:0002895)1.87788207
103Fibular hypoplasia (HP:0003038)1.87614164
104Mitochondrial inheritance (HP:0001427)1.86365315
105Hypoplastic nipples (HP:0002557)1.85669817
106Severe visual impairment (HP:0001141)1.85649433
107Hyperglycinemia (HP:0002154)1.85194788
108Retinal dysplasia (HP:0007973)1.84130996
109Spastic diplegia (HP:0001264)1.83709687
110Abnormal lung lobation (HP:0002101)1.82718752
111Severe muscular hypotonia (HP:0006829)1.82714065
112Broad-based gait (HP:0002136)1.82355005
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81564685
114Preaxial hand polydactyly (HP:0001177)1.81138125
115Lissencephaly (HP:0001339)1.80619433
116Concave nail (HP:0001598)1.80567866
117Long foot (HP:0001833)1.80507848
118Aganglionic megacolon (HP:0002251)1.79701916
119Abnormality of the metopic suture (HP:0005556)1.78820014
120Increased CSF lactate (HP:0002490)1.78432440
121Hypoplastic left heart (HP:0004383)1.78068694
122Horseshoe kidney (HP:0000085)1.77810637
123Abnormality of the fovea (HP:0000493)1.77750696
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77598833
125Brushfield spots (HP:0001088)1.77567646
126Muscle fibrillation (HP:0010546)1.77383506
127Renovascular hypertension (HP:0100817)1.76108573
128Abnormality of the preputium (HP:0100587)1.75173267
129Chorioretinal atrophy (HP:0000533)1.75063261
130Maternal diabetes (HP:0009800)1.74824411
131Renal dysplasia (HP:0000110)1.74804487
132Renal hypoplasia (HP:0000089)1.73890884
133Acute necrotizing encephalopathy (HP:0006965)1.73309147
134Abnormality of macular pigmentation (HP:0008002)1.73280171
135Diastasis recti (HP:0001540)1.72979921
136Megalocornea (HP:0000485)1.72416016
137Respiratory difficulties (HP:0002880)1.72045565
138Neoplasm of the heart (HP:0100544)1.70819256
139Abnormality of the renal medulla (HP:0100957)1.69984972
140Postaxial foot polydactyly (HP:0001830)1.69860118
141Abnormality of the carotid arteries (HP:0005344)1.69506651
142Aplasia/Hypoplasia of the breasts (HP:0010311)1.68419167
143Left ventricular hypertrophy (HP:0001712)1.67116606
144Pelvic girdle muscle weakness (HP:0003749)1.66888440
145Acute encephalopathy (HP:0006846)1.66006457
146Type I transferrin isoform profile (HP:0003642)1.65918001
147Spina bifida occulta (HP:0003298)1.65835754
148Neoplasm of the pancreas (HP:0002894)1.65186992
149Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65099703
150Abnormal protein N-linked glycosylation (HP:0012347)1.65099703
151Abnormal protein glycosylation (HP:0012346)1.65099703
152Abnormal glycosylation (HP:0012345)1.65099703
153Increased intramyocellular lipid droplets (HP:0012240)1.64858497
154Large eyes (HP:0001090)1.64618670
155Abnormality of the clitoris (HP:0000056)1.64324827
156Wide cranial sutures (HP:0010537)1.64150934
157Dental crowding (HP:0000678)1.63992874
158Failure to thrive in infancy (HP:0001531)1.63215215
159Rimmed vacuoles (HP:0003805)1.61938107
160Methylmalonic acidemia (HP:0002912)1.61931264
161Dandy-Walker malformation (HP:0001305)1.61725116
162Mesangial abnormality (HP:0001966)1.61169296
163Abnormal number of incisors (HP:0011064)1.59970604
164Neoplasm of striated muscle (HP:0009728)1.59838661
165Bicornuate uterus (HP:0000813)1.59619842
166Sclerocornea (HP:0000647)1.59081592
167Duodenal stenosis (HP:0100867)1.58748340
168Small intestinal stenosis (HP:0012848)1.58748340
169Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.58497602
170Broad toe (HP:0001837)1.58330401
171Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.58232017
172Broad alveolar ridges (HP:0000187)1.55808500
173Abnormality of chromosome stability (HP:0003220)1.55626574
174Coronal craniosynostosis (HP:0004440)1.54253814
175Aplasia/Hypoplasia of the brainstem (HP:0007362)1.54024403
176Hypoplasia of the brainstem (HP:0002365)1.54024403
177Increased nuchal translucency (HP:0010880)1.53224340
178Agitation (HP:0000713)1.52881516
179Capillary hemangiomas (HP:0005306)1.52205625
180Obsessive-compulsive behavior (HP:0000722)1.52112997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.28994042
2EPHB24.23920709
3TNIK2.75747473
4CASK2.70118212
5STK162.62571562
6BUB12.56899025
7SIK32.41360032
8NME12.40458607
9PDK32.38110761
10PDK42.38110761
11SRPK12.31220503
12KSR12.26587597
13TAOK12.26352050
14DYRK32.19956107
15TRIM282.16844311
16DYRK22.14287548
17MARK12.10148304
18MAP3K92.08021691
19PLK42.07285075
20NUAK12.01113734
21STK38L1.97458061
22TIE11.97328435
23NEK11.93130651
24EIF2AK11.91757715
25ICK1.90866171
26CDC71.84463205
27MKNK11.82095295
28NEK21.78268530
29WEE11.74542349
30MAP4K21.72998039
31ZAK1.71439799
32BCR1.63036521
33RPS6KA41.61516317
34CDK191.58207937
35ACVR1B1.53577167
36MAPK131.50224066
37EEF2K1.43623441
38PLK11.37245588
39MKNK21.36929692
40PLK31.36161740
41PASK1.33491596
42TESK11.33070128
43TAOK21.31062660
44TSSK61.30780146
45FRK1.29785082
46CDK81.26942833
47TGFBR11.26821260
48VRK21.22168928
49PRKD31.19710627
50TLK11.17491677
51NTRK21.14375002
52MAP3K101.10429514
53ERBB31.09925732
54CHEK21.09909056
55CSNK1G21.09441057
56EIF2AK31.09169593
57ATR1.08570952
58CCNB11.07724238
59BRAF1.05767996
60VRK11.03886700
61MAP3K41.03829028
62LIMK11.03576859
63PDK21.03263411
64ERBB21.03001403
65EIF2AK20.97994003
66LATS20.97841164
67MARK30.97488963
68PNCK0.95497490
69AKT30.92492950
70YES10.90312187
71CDK70.89322159
72MAP3K110.88828346
73TTK0.88734536
74GRK10.87500066
75CHEK10.85735343
76BCKDK0.85734777
77FLT30.84073120
78PINK10.83472275
79AURKA0.80717489
80ERBB40.78980560
81PRKCG0.77827145
82PBK0.75689317
83AURKB0.73704752
84PRKCE0.70068763
85MST40.69489527
86BRSK10.68335765
87CDK10.66176982
88STK240.65381283
89OXSR10.65317269
90MAP2K70.63490506
91FGFR10.60282135
92ATM0.59986046
93EPHA40.59717669
94PAK40.58740728
95BRD40.58369206
96CDK20.57610646
97STK30.56731351
98CSNK1G30.56649384
99TESK20.55175841
100MTOR0.52079131
101DYRK1B0.50637352
102CSNK1A10.48223961
103CDK30.46600118
104BMPR1B0.45471014
105CSNK1G10.44654913
106ABL20.44372554
107MINK10.44160656
108BMX0.43111567
109PAK10.42311608
110PKN10.41876436
111INSRR0.40801974
112STK390.40573392
113CDK180.40376065
114MAPKAPK30.40318346
115MARK20.39298591
116SGK20.38717298
117PRKCI0.37974205
118PAK30.37939770
119LATS10.37610970
120UHMK10.36927234
121NTRK30.36703968
122DYRK1A0.36301578
123PKN20.36278262
124AKT20.36101850
125CSNK2A10.35797198
126PIM20.34884490
127BRSK20.34857379
128PHKG10.34588740
129PHKG20.34588740
130PRKAA10.33794916
131PLK20.33505422
132OBSCN0.33402291
133CSNK1E0.32882711
134RPS6KB10.32882480
135CDK11A0.32881844
136FGFR20.32244729
137RPS6KB20.31979431
138CDK40.31928007
139MAP3K30.31524353
140CSNK2A20.30981291
141MAPK90.29910297
142CSNK1A1L0.29321911

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.22137051
2Spliceosome_Homo sapiens_hsa030403.74531810
3Mismatch repair_Homo sapiens_hsa034303.63771615
4Nicotine addiction_Homo sapiens_hsa050333.36068795
5Cell cycle_Homo sapiens_hsa041103.32862501
6Base excision repair_Homo sapiens_hsa034103.21443991
7RNA transport_Homo sapiens_hsa030133.20960216
8Proteasome_Homo sapiens_hsa030503.10120512
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99947657
10RNA polymerase_Homo sapiens_hsa030202.93736945
11Basal transcription factors_Homo sapiens_hsa030222.81745315
12Fanconi anemia pathway_Homo sapiens_hsa034602.52996863
13Nucleotide excision repair_Homo sapiens_hsa034202.50321721
14mRNA surveillance pathway_Homo sapiens_hsa030152.48821251
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.43630688
16Pyrimidine metabolism_Homo sapiens_hsa002402.24495549
17RNA degradation_Homo sapiens_hsa030182.17913815
18Homologous recombination_Homo sapiens_hsa034402.10615694
19Butanoate metabolism_Homo sapiens_hsa006502.09174229
20Phototransduction_Homo sapiens_hsa047441.97312849
21Oxidative phosphorylation_Homo sapiens_hsa001901.95638501
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92063851
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.82638104
24Ribosome_Homo sapiens_hsa030101.77090495
25One carbon pool by folate_Homo sapiens_hsa006701.72170804
26Steroid biosynthesis_Homo sapiens_hsa001001.67380707
27Basal cell carcinoma_Homo sapiens_hsa052171.65167787
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49807682
29Oocyte meiosis_Homo sapiens_hsa041141.48959957
30Fatty acid elongation_Homo sapiens_hsa000621.46956491
31Selenocompound metabolism_Homo sapiens_hsa004501.40702873
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36481252
33Peroxisome_Homo sapiens_hsa041461.33959806
34Epstein-Barr virus infection_Homo sapiens_hsa051691.30885275
35Purine metabolism_Homo sapiens_hsa002301.30331964
36Colorectal cancer_Homo sapiens_hsa052101.29431649
37Non-homologous end-joining_Homo sapiens_hsa034501.28530532
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25689646
39Hippo signaling pathway_Homo sapiens_hsa043901.25475221
40beta-Alanine metabolism_Homo sapiens_hsa004101.24079578
41Caffeine metabolism_Homo sapiens_hsa002321.14597632
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11762856
43Hedgehog signaling pathway_Homo sapiens_hsa043401.09680960
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09085616
45Tryptophan metabolism_Homo sapiens_hsa003801.05016489
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04604632
47p53 signaling pathway_Homo sapiens_hsa041151.02402291
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01007117
49Regulation of autophagy_Homo sapiens_hsa041400.99704921
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.99383023
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94757017
52Notch signaling pathway_Homo sapiens_hsa043300.94710108
53TGF-beta signaling pathway_Homo sapiens_hsa043500.94035633
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93397031
55Alzheimers disease_Homo sapiens_hsa050100.91866963
56Pyruvate metabolism_Homo sapiens_hsa006200.88383212
57Vitamin B6 metabolism_Homo sapiens_hsa007500.87014625
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86377514
59Biosynthesis of amino acids_Homo sapiens_hsa012300.83316068
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83195033
61Fatty acid metabolism_Homo sapiens_hsa012120.81264884
62Sulfur relay system_Homo sapiens_hsa041220.80643685
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80041854
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.79734202
65Taste transduction_Homo sapiens_hsa047420.78593452
66Nitrogen metabolism_Homo sapiens_hsa009100.77483926
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77253100
68Endometrial cancer_Homo sapiens_hsa052130.76978324
69Cocaine addiction_Homo sapiens_hsa050300.76874732
70Huntingtons disease_Homo sapiens_hsa050160.75475081
71Axon guidance_Homo sapiens_hsa043600.75405205
72MicroRNAs in cancer_Homo sapiens_hsa052060.73079070
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73037522
74Carbon metabolism_Homo sapiens_hsa012000.71570453
75Synaptic vesicle cycle_Homo sapiens_hsa047210.69851043
76GABAergic synapse_Homo sapiens_hsa047270.68985421
77HTLV-I infection_Homo sapiens_hsa051660.68529786
78Systemic lupus erythematosus_Homo sapiens_hsa053220.68454698
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68048278
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64897831
81Lysine degradation_Homo sapiens_hsa003100.64144628
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.63327437
83Circadian rhythm_Homo sapiens_hsa047100.62274662
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60994505
85Wnt signaling pathway_Homo sapiens_hsa043100.60713086
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59874405
87N-Glycan biosynthesis_Homo sapiens_hsa005100.59043173
88Viral carcinogenesis_Homo sapiens_hsa052030.58321399
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58093023
90Thyroid cancer_Homo sapiens_hsa052160.55813166
91Morphine addiction_Homo sapiens_hsa050320.54467389
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54241487
93Herpes simplex infection_Homo sapiens_hsa051680.53407434
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50030020
95Renin-angiotensin system_Homo sapiens_hsa046140.50025314
96Pentose phosphate pathway_Homo sapiens_hsa000300.49360791
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48803389
98Collecting duct acid secretion_Homo sapiens_hsa049660.48655899
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48192686
100mTOR signaling pathway_Homo sapiens_hsa041500.48188972
101Chronic myeloid leukemia_Homo sapiens_hsa052200.47485972
102Chemical carcinogenesis_Homo sapiens_hsa052040.47240427
103Olfactory transduction_Homo sapiens_hsa047400.46539298
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45846967
105Glycerolipid metabolism_Homo sapiens_hsa005610.44841808
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.44705933
107Fatty acid biosynthesis_Homo sapiens_hsa000610.43187074
108Fatty acid degradation_Homo sapiens_hsa000710.43004308
109Retinol metabolism_Homo sapiens_hsa008300.41989388
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41907964
111Pathways in cancer_Homo sapiens_hsa052000.40917608
112Glutamatergic synapse_Homo sapiens_hsa047240.40811572
113Alcoholism_Homo sapiens_hsa050340.40747707
114Protein export_Homo sapiens_hsa030600.40561812
115Adherens junction_Homo sapiens_hsa045200.40357082
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39104168
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38904287
118Propanoate metabolism_Homo sapiens_hsa006400.38721528
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38252139
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38219498
121Pancreatic cancer_Homo sapiens_hsa052120.38186232
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37772436
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37349102
124AMPK signaling pathway_Homo sapiens_hsa041520.36355334
125Parkinsons disease_Homo sapiens_hsa050120.34728290
126Viral myocarditis_Homo sapiens_hsa054160.32239039
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29778980
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29020256
129Cardiac muscle contraction_Homo sapiens_hsa042600.28803672
130Folate biosynthesis_Homo sapiens_hsa007900.27632456
131Glucagon signaling pathway_Homo sapiens_hsa049220.27125299
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.26646178
133Insulin signaling pathway_Homo sapiens_hsa049100.24934472
134Small cell lung cancer_Homo sapiens_hsa052220.24552568
135Metabolic pathways_Homo sapiens_hsa011000.23003505
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.21860709
137Prostate cancer_Homo sapiens_hsa052150.21710307
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20902923
139Tight junction_Homo sapiens_hsa045300.19710196
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.17894710
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17304087
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17053524
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16996833
144Glutathione metabolism_Homo sapiens_hsa004800.16559018
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13420644

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