ZSCAN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of amino acid transport (GO:0051957)6.50182589
2epithelial cilium movement (GO:0003351)5.45830953
3negative regulation of neurotransmitter secretion (GO:0046929)5.15258185
4negative regulation of amino acid transport (GO:0051956)5.06551209
5positive regulation of catecholamine secretion (GO:0033605)4.80216158
6pyrimidine nucleobase catabolic process (GO:0006208)4.78343531
7cilium movement (GO:0003341)4.63967654
8regulation of glutamate secretion (GO:0014048)4.61988707
9regulation of dopamine secretion (GO:0014059)4.40263203
10negative regulation of neurotransmitter transport (GO:0051589)4.21188155
11auditory behavior (GO:0031223)4.19276423
12substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.10534556
13substrate-independent telencephalic tangential migration (GO:0021826)4.10534556
14nucleobase catabolic process (GO:0046113)4.09052595
15axonemal dynein complex assembly (GO:0070286)4.08206580
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.07289142
17left/right pattern formation (GO:0060972)3.98785116
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.97259264
19serotonin receptor signaling pathway (GO:0007210)3.93234098
20positive regulation of amine transport (GO:0051954)3.88499486
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78655197
22intraciliary transport (GO:0042073)3.72800304
23mechanosensory behavior (GO:0007638)3.72044497
24base-excision repair, AP site formation (GO:0006285)3.71534211
25regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.67200487
26regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.67200487
27pyrimidine nucleotide catabolic process (GO:0006244)3.65478723
28behavioral response to nicotine (GO:0035095)3.64230385
29GTP biosynthetic process (GO:0006183)3.58028143
30regulation of neurotransmitter uptake (GO:0051580)3.52719155
31cullin deneddylation (GO:0010388)3.49515039
32postsynaptic membrane organization (GO:0001941)3.47203262
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41301038
34protein complex biogenesis (GO:0070271)3.40160007
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.38645441
36regulation of amino acid transport (GO:0051955)3.35865993
37positive regulation of organic acid transport (GO:0032892)3.34863034
38negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33630625
39cilium or flagellum-dependent cell motility (GO:0001539)3.30659854
40protein deneddylation (GO:0000338)3.30109903
41presynaptic membrane assembly (GO:0097105)3.29986778
42response to auditory stimulus (GO:0010996)3.28872752
43neuron cell-cell adhesion (GO:0007158)3.28372125
44behavioral response to cocaine (GO:0048148)3.28267459
45presynaptic membrane organization (GO:0097090)3.25986832
46synaptic transmission, dopaminergic (GO:0001963)3.22832329
47behavioral response to ethanol (GO:0048149)3.18158491
48dendritic spine morphogenesis (GO:0060997)3.11275043
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10910017
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.10910017
51NADH dehydrogenase complex assembly (GO:0010257)3.10910017
52axoneme assembly (GO:0035082)3.10847977
53nonmotile primary cilium assembly (GO:0035058)3.07962259
54synapse assembly (GO:0007416)3.03152375
55UTP biosynthetic process (GO:0006228)3.02148606
56mitochondrial respiratory chain complex assembly (GO:0033108)3.00402602
57establishment of mitochondrion localization (GO:0051654)2.99410113
58nucleoside diphosphate phosphorylation (GO:0006165)2.90171316
59prepulse inhibition (GO:0060134)2.90074536
60glycerophospholipid catabolic process (GO:0046475)2.86474822
61UTP metabolic process (GO:0046051)2.82500921
62regulation of cilium movement (GO:0003352)2.81867367
63axonal fasciculation (GO:0007413)2.77486981
64regulation of synapse structural plasticity (GO:0051823)2.77049452
65determination of left/right symmetry (GO:0007368)2.76046857
66branched-chain amino acid catabolic process (GO:0009083)2.74010857
67epithelial cell fate commitment (GO:0072148)2.73087952
68transmission of nerve impulse (GO:0019226)2.71823119
69phospholipid scrambling (GO:0017121)2.71415729
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69698191
71negative regulation of amine transport (GO:0051953)2.65745202
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65717131
73vocalization behavior (GO:0071625)2.65024686
74protein localization to synapse (GO:0035418)2.64617622
75aggressive behavior (GO:0002118)2.61974218
76synaptic transmission, glutamatergic (GO:0035249)2.61177722
77response to histamine (GO:0034776)2.60548166
78gamma-aminobutyric acid transport (GO:0015812)2.60408488
79N-glycan processing (GO:0006491)2.59924850
80determination of bilateral symmetry (GO:0009855)2.59878402
81cilium assembly (GO:0042384)2.59635634
82cilium organization (GO:0044782)2.59168353
83synaptic vesicle maturation (GO:0016188)2.58756756
84CTP biosynthetic process (GO:0006241)2.57500340
85CTP metabolic process (GO:0046036)2.57500340
86regulation of neurotransmitter transport (GO:0051588)2.57350772
87short-term memory (GO:0007614)2.54651482
88neuron-neuron synaptic transmission (GO:0007270)2.54526585
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52142273
90negative regulation of oligodendrocyte differentiation (GO:0048715)2.52055663
91specification of symmetry (GO:0009799)2.51634309
92positive regulation of potassium ion transmembrane transport (GO:1901381)2.51343958
93sequestering of actin monomers (GO:0042989)2.50725060
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.50614939
95protein localization to cilium (GO:0061512)2.48890232
96protein polyglutamylation (GO:0018095)2.48259730
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46541608
98long-term synaptic potentiation (GO:0060291)2.46342372
99cilium morphogenesis (GO:0060271)2.45175799
100regulation of neurotransmitter secretion (GO:0046928)2.45022242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90543054
2IGF1R_20145208_ChIP-Seq_DFB_Human3.71133257
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.31477757
4ZNF274_21170338_ChIP-Seq_K562_Hela2.82856259
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67259538
6GBX2_23144817_ChIP-Seq_PC3_Human2.55153659
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.24745959
8REST_21632747_ChIP-Seq_MESCs_Mouse2.24384636
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.22910084
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12693932
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07979764
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07298629
13VDR_22108803_ChIP-Seq_LS180_Human2.04152470
14RNF2_27304074_Chip-Seq_NSC_Mouse2.03857975
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02889004
16REST_18959480_ChIP-ChIP_MESCs_Mouse1.95771330
17FUS_26573619_Chip-Seq_HEK293_Human1.95121351
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93212852
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92554738
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92046549
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80995057
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78723797
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75786786
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75329728
25P300_19829295_ChIP-Seq_ESCs_Human1.73243203
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.73234090
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.72269689
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69158988
29EWS_26573619_Chip-Seq_HEK293_Human1.67872226
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62619806
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62066090
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61961979
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61841362
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61828025
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59548048
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59250940
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51180288
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44671705
39SMAD4_21799915_ChIP-Seq_A2780_Human1.42916933
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42233112
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40187150
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.39927051
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35054845
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34719542
45HTT_18923047_ChIP-ChIP_STHdh_Human1.34300897
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.32087638
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32041726
48TP53_22573176_ChIP-Seq_HFKS_Human1.31951746
49AR_25329375_ChIP-Seq_VCAP_Human1.31859477
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28528991
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27916792
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27235934
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27235934
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26914604
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25782381
56TAF15_26573619_Chip-Seq_HEK293_Human1.24193212
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23551840
58ER_23166858_ChIP-Seq_MCF-7_Human1.21309074
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.20979195
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19296057
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19296057
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18939553
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18068606
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17677969
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15571966
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15039169
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14709013
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.13647141
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12952634
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.10886370
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.10493060
72RUNX2_22187159_ChIP-Seq_PCA_Human1.09826074
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09378510
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07831946
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06904410
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06567045
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05588832
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05226270
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04311800
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03152781
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02840873
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02589231
83P53_22387025_ChIP-Seq_ESCs_Mouse1.02546368
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.02285312
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01946440
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99745462
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99155844
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98613956
89NCOR_22424771_ChIP-Seq_293T_Human0.98058810
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.98026743
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97866916
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97851070
93CBP_20019798_ChIP-Seq_JUKART_Human0.97851070
94DROSHA_22980978_ChIP-Seq_HELA_Human0.97209538
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96545561
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96479065
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93921638
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93612858
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92850730
100STAT3_23295773_ChIP-Seq_U87_Human0.92036878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.73310674
2MP0001529_abnormal_vocalization3.17119029
3MP0002234_abnormal_pharynx_morphology2.62196735
4MP0008961_abnormal_basal_metabolism2.54408743
5MP0003880_abnormal_central_pattern2.53782645
6MP0003787_abnormal_imprinting2.48225992
7MP0005645_abnormal_hypothalamus_physiol2.45812547
8MP0003122_maternal_imprinting2.38561603
9MP0006276_abnormal_autonomic_nervous2.35467729
10MP0002735_abnormal_chemical_nociception2.24438641
11MP0004859_abnormal_synaptic_plasticity2.23197586
12MP0009745_abnormal_behavioral_response2.21030504
13MP0004133_heterotaxia2.04864957
14MP0002909_abnormal_adrenal_gland2.03510960
15MP0004270_analgesia1.99596446
16MP0003121_genomic_imprinting1.96416223
17MP0009046_muscle_twitch1.91966738
18MP0005423_abnormal_somatic_nervous1.89410426
19MP0001984_abnormal_olfaction1.89127268
20MP0005646_abnormal_pituitary_gland1.87893843
21MP0005084_abnormal_gallbladder_morpholo1.82499864
22MP0001188_hyperpigmentation1.82453114
23MP0001486_abnormal_startle_reflex1.81907259
24MP0001905_abnormal_dopamine_level1.78783362
25MP0002272_abnormal_nervous_system1.77328355
26MP0001968_abnormal_touch/_nociception1.76520779
27MP0002572_abnormal_emotion/affect_behav1.73225239
28MP0002734_abnormal_mechanical_nocicepti1.72289508
29MP0000778_abnormal_nervous_system1.71856654
30MP0005551_abnormal_eye_electrophysiolog1.69735517
31MP0003635_abnormal_synaptic_transmissio1.68806387
32MP0003011_delayed_dark_adaptation1.65451000
33MP0002064_seizures1.64990200
34MP0002063_abnormal_learning/memory/cond1.63373097
35MP0002557_abnormal_social/conspecific_i1.63044771
36MP0000566_synostosis1.61881878
37MP0000631_abnormal_neuroendocrine_gland1.61445577
38MP0004142_abnormal_muscle_tone1.61350137
39MP0002733_abnormal_thermal_nociception1.59126711
40MP0002653_abnormal_ependyma_morphology1.58368733
41MP0002163_abnormal_gland_morphology1.55086378
42MP0008877_abnormal_DNA_methylation1.52198497
43MP0001970_abnormal_pain_threshold1.51756463
44MP0003123_paternal_imprinting1.51428789
45MP0006072_abnormal_retinal_apoptosis1.51193471
46MP0002638_abnormal_pupillary_reflex1.49242336
47MP0002736_abnormal_nociception_after1.43509694
48MP0002102_abnormal_ear_morphology1.42452562
49MP0008789_abnormal_olfactory_epithelium1.35208421
50MP0005379_endocrine/exocrine_gland_phen1.34616892
51MP0004885_abnormal_endolymph1.32827549
52MP0008995_early_reproductive_senescence1.32601192
53MP0005394_taste/olfaction_phenotype1.29514459
54MP0005499_abnormal_olfactory_system1.29514459
55MP0000049_abnormal_middle_ear1.25135544
56MP0002067_abnormal_sensory_capabilities1.23897176
57MP0006292_abnormal_olfactory_placode1.22879808
58MP0005253_abnormal_eye_physiology1.17798545
59MP0002837_dystrophic_cardiac_calcinosis1.17143233
60MP0005386_behavior/neurological_phenoty1.15014536
61MP0004924_abnormal_behavior1.15014536
62MP0002882_abnormal_neuron_morphology1.09854560
63MP0002184_abnormal_innervation1.09349804
64MP0000955_abnormal_spinal_cord1.08685981
65MP0003119_abnormal_digestive_system1.08669147
66MP0000026_abnormal_inner_ear1.08360199
67MP0001963_abnormal_hearing_physiology1.03407278
68MP0004043_abnormal_pH_regulation1.00618622
69MP0003878_abnormal_ear_physiology1.00213343
70MP0005377_hearing/vestibular/ear_phenot1.00213343
71MP0002752_abnormal_somatic_nervous0.98492806
72MP0000639_abnormal_adrenal_gland0.97299935
73MP0004811_abnormal_neuron_physiology0.96622983
74MP0001502_abnormal_circadian_rhythm0.96197018
75MP0001485_abnormal_pinna_reflex0.95106422
76MP0003137_abnormal_impulse_conducting0.93482152
77MP0002090_abnormal_vision0.93471421
78MP0003283_abnormal_digestive_organ0.91312035
79MP0005195_abnormal_posterior_eye0.89875825
80MP0002928_abnormal_bile_duct0.89679975
81MP0002069_abnormal_eating/drinking_beha0.89655947
82MP0009780_abnormal_chondrocyte_physiolo0.86691342
83MP0001440_abnormal_grooming_behavior0.84630086
84MP0008569_lethality_at_weaning0.84360179
85MP0004215_abnormal_myocardial_fiber0.83851384
86MP0002229_neurodegeneration0.83793182
87MP0002066_abnormal_motor_capabilities/c0.82858903
88MP0002152_abnormal_brain_morphology0.81517905
89MP0003938_abnormal_ear_development0.79195655
90MP0003183_abnormal_peptide_metabolism0.79053531
91MP0003633_abnormal_nervous_system0.78914814
92MP0001270_distended_abdomen0.78898121
93MP0000613_abnormal_salivary_gland0.72645041
94MP0003879_abnormal_hair_cell0.72383921
95MP0005248_abnormal_Harderian_gland0.72219581
96MP0001986_abnormal_taste_sensitivity0.71008802
97MP0002233_abnormal_nose_morphology0.70909568
98MP0002938_white_spotting0.70871085
99MP0002160_abnormal_reproductive_system0.68912260
100MP0005187_abnormal_penis_morphology0.65540908

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.95168777
2Abnormal respiratory epithelium morphology (HP:0012253)3.91903881
3Abnormal respiratory motile cilium morphology (HP:0005938)3.91903881
4Abnormal ciliary motility (HP:0012262)3.83321646
5Abnormal respiratory motile cilium physiology (HP:0012261)3.71503502
6Hyperglycinemia (HP:0002154)3.70443499
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.60386388
8Myokymia (HP:0002411)3.56484184
9Gait imbalance (HP:0002141)3.52861757
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.36857890
11Absent/shortened dynein arms (HP:0200106)3.36857890
12Abnormality of midbrain morphology (HP:0002418)3.31426339
13Molar tooth sign on MRI (HP:0002419)3.31426339
14Congenital primary aphakia (HP:0007707)3.27262748
15Abnormal rod and cone electroretinograms (HP:0008323)3.14790505
16True hermaphroditism (HP:0010459)3.11753332
17Nephrogenic diabetes insipidus (HP:0009806)3.10805458
18Increased hepatocellular lipid droplets (HP:0006565)3.05515403
19Rhinitis (HP:0012384)2.90859302
20Polyphagia (HP:0002591)2.88613876
21Lipid accumulation in hepatocytes (HP:0006561)2.86555768
22Pancreatic fibrosis (HP:0100732)2.84283346
23Nephronophthisis (HP:0000090)2.81620205
24Limb dystonia (HP:0002451)2.77628742
25Methylmalonic acidemia (HP:0002912)2.75532774
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73938703
27Abnormality of the labia minora (HP:0012880)2.58865527
28Ketosis (HP:0001946)2.53485967
29Cerebral edema (HP:0002181)2.53164910
30Agitation (HP:0000713)2.53120451
31Mitochondrial inheritance (HP:0001427)2.50892749
32Short 1st metacarpal (HP:0010034)2.46669379
33Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.46669379
34Genital tract atresia (HP:0001827)2.45500514
35Vaginal atresia (HP:0000148)2.44390930
36Pancreatic cysts (HP:0001737)2.43734307
37Acute necrotizing encephalopathy (HP:0006965)2.40963742
38Broad-based gait (HP:0002136)2.37068757
39Hepatoblastoma (HP:0002884)2.35102061
40Poor suck (HP:0002033)2.33267587
41Chronic bronchitis (HP:0004469)2.26549077
42Renal Fanconi syndrome (HP:0001994)2.26071549
43Abnormality of the renal medulla (HP:0100957)2.25878731
44Poor coordination (HP:0002370)2.24493457
45Acute encephalopathy (HP:0006846)2.22702517
46Occipital encephalocele (HP:0002085)2.21760056
47Abnormal mitochondria in muscle tissue (HP:0008316)2.21448493
48Abnormality of the 1st metacarpal (HP:0010009)2.21437733
49Focal motor seizures (HP:0011153)2.21085654
50Postaxial hand polydactyly (HP:0001162)2.15826495
51Increased CSF lactate (HP:0002490)2.14878616
52Specific learning disability (HP:0001328)2.14483496
53Congenital stationary night blindness (HP:0007642)2.14391393
54Fetal akinesia sequence (HP:0001989)2.10978019
55Drooling (HP:0002307)2.09108638
56Narrow forehead (HP:0000341)2.07292075
57Abnormality of the renal collecting system (HP:0004742)2.06453408
58Optic disc pallor (HP:0000543)2.04826154
59Methylmalonic aciduria (HP:0012120)2.02613597
60Chronic hepatic failure (HP:0100626)2.02264306
61Progressive macrocephaly (HP:0004481)2.01964783
62Pachygyria (HP:0001302)1.98782925
63Renal dysplasia (HP:0000110)1.97404491
64Decreased testicular size (HP:0008734)1.96421335
65Inability to walk (HP:0002540)1.95006194
66Increased intramyocellular lipid droplets (HP:0012240)1.93672836
67Hepatocellular necrosis (HP:0001404)1.93634083
683-Methylglutaconic aciduria (HP:0003535)1.92193306
69Retinal dysplasia (HP:0007973)1.91705860
70Tubulointerstitial nephritis (HP:0001970)1.91649714
71Focal seizures (HP:0007359)1.91569469
72Bony spicule pigmentary retinopathy (HP:0007737)1.90386845
73Attenuation of retinal blood vessels (HP:0007843)1.89854002
74Sclerocornea (HP:0000647)1.89781704
75Cerebral hypomyelination (HP:0006808)1.89335594
76Abnormality of glycine metabolism (HP:0010895)1.89017195
77Abnormality of serine family amino acid metabolism (HP:0010894)1.89017195
78Exertional dyspnea (HP:0002875)1.86654433
79Excessive salivation (HP:0003781)1.86275579
80Intestinal atresia (HP:0011100)1.85657365
81Cystic liver disease (HP:0006706)1.84827214
82Stenosis of the external auditory canal (HP:0000402)1.84338569
83Epileptic encephalopathy (HP:0200134)1.83698871
84Hemiparesis (HP:0001269)1.82424382
85Abolished electroretinogram (ERG) (HP:0000550)1.81770763
86Failure to thrive in infancy (HP:0001531)1.81544156
87Action tremor (HP:0002345)1.80268965
88Broad foot (HP:0001769)1.79434253
89Short phalanx of the thumb (HP:0009660)1.78806300
90Lactic acidosis (HP:0003128)1.78178099
91Anencephaly (HP:0002323)1.76130005
92Type II lissencephaly (HP:0007260)1.76050440
93Brushfield spots (HP:0001088)1.76008551
94Keratoconus (HP:0000563)1.73994695
95Increased corneal curvature (HP:0100692)1.73994695
96Rib fusion (HP:0000902)1.73877535
97Aplasia/Hypoplasia of the lens (HP:0008063)1.73727787
98Hypsarrhythmia (HP:0002521)1.72423180
99Bronchiectasis (HP:0002110)1.72085190
100Torticollis (HP:0000473)1.71729568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.61517961
2STK163.97428239
3MAP2K72.82837483
4EIF2AK32.62196545
5MAP3K42.47295416
6WNK32.45847621
7MARK12.36691007
8MAP4K22.31645085
9CASK2.16708937
10MAPK131.98619654
11DYRK21.91523380
12FRK1.66152553
13PINK11.66069307
14TRIM281.54923967
15BCR1.53994821
16NTRK31.51053169
17ADRBK21.48503756
18EPHA31.48366317
19WNK41.44707646
20EPHA41.41582549
21MAPK151.41051839
22NTRK21.40885198
23CSNK1A1L1.30846088
24CSNK1G21.23323018
25CSNK1G31.22584049
26MAP2K41.20506237
27PRKCG1.13290299
28PAK31.12612571
29GRK11.11132436
30CSNK1G11.10743133
31INSRR1.04213921
32FGFR21.03821523
33PLK21.02892514
34MINK10.98062558
35PIM20.97180335
36PNCK0.95552762
37UHMK10.90126608
38PHKG20.87347848
39PHKG10.87347848
40BMPR1B0.86611335
41PRKCE0.84070037
42ERBB30.75953126
43TLK10.75572155
44DAPK20.73811014
45DYRK1B0.73625298
46DYRK1A0.70474449
47CDK50.70121613
48MAP2K60.69941782
49STK390.69253140
50CDK190.68636155
51STK110.67024447
52SGK4940.65056446
53SGK2230.65056446
54PRKD20.63554173
55PKN10.62510006
56CCNB10.58908254
57DYRK30.57631653
58TAOK30.55140438
59TAOK10.54641289
60CDK80.53953619
61OXSR10.53762085
62CSNK1A10.53573536
63CAMK2A0.52620906
64RPS6KA50.50289622
65PRKD30.48220191
66CAMK2B0.46568495
67PAK60.46129992
68PRKACA0.45583506
69CDK140.43392003
70PLK40.42277621
71EIF2AK20.41491406
72PRKCI0.40139145
73PRKCZ0.40124729
74VRK10.38957470
75RPS6KA40.38692733
76TIE10.38368494
77IRAK10.37677519
78AKT20.37455237
79SGK10.33449356
80PRKG10.32077165
81FER0.31768327
82MAPKAPK50.30992373
83ABL20.30858024
84AURKA0.29120922
85CSNK1E0.28675236
86CAMK2D0.27739120
87PRKDC0.27678631
88SIK20.26999876
89CSNK1D0.26933946
90ADRBK10.26917328
91TYRO30.26287929
92ABL10.25034959
93CAMK10.24855366
94SGK20.24494089
95MUSK0.24336930
96CAMK2G0.24211289
97PRKCA0.23747331
98PRKCH0.22772968
99STK380.22590228
100NUAK10.22526065

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17553174
2Nicotine addiction_Homo sapiens_hsa050332.94075976
3Oxidative phosphorylation_Homo sapiens_hsa001902.81867327
4Sulfur relay system_Homo sapiens_hsa041222.81366998
5Propanoate metabolism_Homo sapiens_hsa006402.64829863
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.51960321
7Parkinsons disease_Homo sapiens_hsa050122.47722127
8Folate biosynthesis_Homo sapiens_hsa007902.47437197
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45862352
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38455547
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.32096222
12Butanoate metabolism_Homo sapiens_hsa006501.96019606
13Cocaine addiction_Homo sapiens_hsa050301.88394183
14Phototransduction_Homo sapiens_hsa047441.84654396
15Cardiac muscle contraction_Homo sapiens_hsa042601.82286641
16Steroid biosynthesis_Homo sapiens_hsa001001.81471393
17GABAergic synapse_Homo sapiens_hsa047271.80701604
18Morphine addiction_Homo sapiens_hsa050321.63211168
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58152755
20Alzheimers disease_Homo sapiens_hsa050101.57790804
21Synaptic vesicle cycle_Homo sapiens_hsa047211.55927373
22Huntingtons disease_Homo sapiens_hsa050161.55741627
23Dopaminergic synapse_Homo sapiens_hsa047281.55584062
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.51168969
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50078023
26Circadian entrainment_Homo sapiens_hsa047131.48977813
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47594982
28Protein export_Homo sapiens_hsa030601.46881695
29Collecting duct acid secretion_Homo sapiens_hsa049661.39211463
30Glutamatergic synapse_Homo sapiens_hsa047241.38070418
31Insulin secretion_Homo sapiens_hsa049111.30272556
32Peroxisome_Homo sapiens_hsa041461.27349703
33Serotonergic synapse_Homo sapiens_hsa047261.25416694
34Amphetamine addiction_Homo sapiens_hsa050311.21934349
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20513879
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16650827
37Regulation of autophagy_Homo sapiens_hsa041401.14726304
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13998619
39Taste transduction_Homo sapiens_hsa047421.12422811
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11175185
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08853366
42Olfactory transduction_Homo sapiens_hsa047401.04181616
43Linoleic acid metabolism_Homo sapiens_hsa005911.02862357
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00766645
45Fatty acid elongation_Homo sapiens_hsa000620.98587684
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96186622
47Ether lipid metabolism_Homo sapiens_hsa005650.95942554
48beta-Alanine metabolism_Homo sapiens_hsa004100.90733148
49Fanconi anemia pathway_Homo sapiens_hsa034600.89612810
50cAMP signaling pathway_Homo sapiens_hsa040240.84794370
51Tryptophan metabolism_Homo sapiens_hsa003800.83664773
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80910322
53Axon guidance_Homo sapiens_hsa043600.80407160
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.79156339
55Hedgehog signaling pathway_Homo sapiens_hsa043400.79050765
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77564625
57Retinol metabolism_Homo sapiens_hsa008300.76825450
58Salivary secretion_Homo sapiens_hsa049700.76220666
59Calcium signaling pathway_Homo sapiens_hsa040200.76095184
60Long-term depression_Homo sapiens_hsa047300.74315479
61Metabolic pathways_Homo sapiens_hsa011000.72272314
62Basal transcription factors_Homo sapiens_hsa030220.71676199
63Base excision repair_Homo sapiens_hsa034100.71439315
64Nitrogen metabolism_Homo sapiens_hsa009100.69907967
65Renin secretion_Homo sapiens_hsa049240.69506808
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67825004
67Fatty acid metabolism_Homo sapiens_hsa012120.66365956
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63954691
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63232670
70Basal cell carcinoma_Homo sapiens_hsa052170.62840590
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60214279
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58583593
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58413285
74Sulfur metabolism_Homo sapiens_hsa009200.57428448
75Cholinergic synapse_Homo sapiens_hsa047250.57421406
76Chemical carcinogenesis_Homo sapiens_hsa052040.55012123
77Gastric acid secretion_Homo sapiens_hsa049710.55003620
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54254481
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54220254
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54056966
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.53816605
82Fatty acid degradation_Homo sapiens_hsa000710.53789158
83Starch and sucrose metabolism_Homo sapiens_hsa005000.53056947
84Oocyte meiosis_Homo sapiens_hsa041140.52347798
85Gap junction_Homo sapiens_hsa045400.51116614
86Purine metabolism_Homo sapiens_hsa002300.49908895
87N-Glycan biosynthesis_Homo sapiens_hsa005100.45068108
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44278943
89Oxytocin signaling pathway_Homo sapiens_hsa049210.43946139
90Selenocompound metabolism_Homo sapiens_hsa004500.41918756
91Histidine metabolism_Homo sapiens_hsa003400.40488009
92Vibrio cholerae infection_Homo sapiens_hsa051100.40333046
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38281982
94ABC transporters_Homo sapiens_hsa020100.38078026
95Alcoholism_Homo sapiens_hsa050340.37306422
96Ovarian steroidogenesis_Homo sapiens_hsa049130.35438132
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34279977
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34234767
99Arginine and proline metabolism_Homo sapiens_hsa003300.33224782
100RNA polymerase_Homo sapiens_hsa030200.31720702

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