ZNHIT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.09778280
2maturation of SSU-rRNA (GO:0030490)4.96470266
3* ribosome biogenesis (GO:0042254)4.57466323
4ribosome assembly (GO:0042255)4.56736260
5purine nucleobase biosynthetic process (GO:0009113)4.56203799
6DNA deamination (GO:0045006)4.52849505
7DNA replication checkpoint (GO:0000076)4.48785028
8nucleobase biosynthetic process (GO:0046112)4.42540999
9formation of translation preinitiation complex (GO:0001731)4.35785631
10* ribonucleoprotein complex biogenesis (GO:0022613)4.29944818
11protein localization to kinetochore (GO:0034501)4.21479297
12metaphase plate congression (GO:0051310)4.15014656
13ribosomal large subunit biogenesis (GO:0042273)4.10128310
14ribosomal small subunit assembly (GO:0000028)3.98563128
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.98117344
16ribosomal small subunit biogenesis (GO:0042274)3.95703462
17rRNA modification (GO:0000154)3.93494246
18rRNA processing (GO:0006364)3.92055887
19DNA replication initiation (GO:0006270)3.84847150
20DNA strand elongation involved in DNA replication (GO:0006271)3.84723093
21translational termination (GO:0006415)3.83366684
22CENP-A containing nucleosome assembly (GO:0034080)3.83129049
23viral transcription (GO:0019083)3.83121048
24protein localization to chromosome, centromeric region (GO:0071459)3.80651896
25rRNA metabolic process (GO:0016072)3.80502774
26chromatin remodeling at centromere (GO:0031055)3.76699916
27maturation of 5.8S rRNA (GO:0000460)3.76157137
28mitotic nuclear envelope disassembly (GO:0007077)3.75887930
29spliceosomal snRNP assembly (GO:0000387)3.75055014
30translational initiation (GO:0006413)3.71437311
31kinetochore assembly (GO:0051382)3.68721191
32kinetochore organization (GO:0051383)3.68082917
33regulation of spindle organization (GO:0090224)3.66315093
34DNA strand elongation (GO:0022616)3.64511272
35regulation of DNA endoreduplication (GO:0032875)3.62964775
36proteasome assembly (GO:0043248)3.62581623
37regulation of centriole replication (GO:0046599)3.58855046
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.56089876
39termination of RNA polymerase III transcription (GO:0006386)3.56089876
40DNA replication-independent nucleosome organization (GO:0034724)3.55373176
41DNA replication-independent nucleosome assembly (GO:0006336)3.55373176
42nuclear envelope disassembly (GO:0051081)3.51704153
43membrane disassembly (GO:0030397)3.51704153
44establishment of chromosome localization (GO:0051303)3.51235388
45water-soluble vitamin biosynthetic process (GO:0042364)3.51148803
46telomere maintenance via semi-conservative replication (GO:0032201)3.50015598
47pseudouridine synthesis (GO:0001522)3.48906997
48termination of RNA polymerase I transcription (GO:0006363)3.47141165
49translational elongation (GO:0006414)3.46063037
50transcription from RNA polymerase I promoter (GO:0006360)3.44052384
51DNA damage response, detection of DNA damage (GO:0042769)3.38675093
52transcription elongation from RNA polymerase I promoter (GO:0006362)3.38250789
537-methylguanosine mRNA capping (GO:0006370)3.37046632
54histone exchange (GO:0043486)3.34740583
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.34703100
56DNA replication-dependent nucleosome organization (GO:0034723)3.34538642
57DNA replication-dependent nucleosome assembly (GO:0006335)3.34538642
58RNA capping (GO:0036260)3.34303479
597-methylguanosine RNA capping (GO:0009452)3.34303479
60telomere maintenance via recombination (GO:0000722)3.33192032
61IMP biosynthetic process (GO:0006188)3.30963152
62spindle checkpoint (GO:0031577)3.29670485
63nuclear pore organization (GO:0006999)3.26498421
64positive regulation of chromosome segregation (GO:0051984)3.25835613
65tRNA methylation (GO:0030488)3.25712659
66negative regulation of chromosome segregation (GO:0051985)3.24935165
67attachment of spindle microtubules to kinetochore (GO:0008608)3.24543977
68transcription-coupled nucleotide-excision repair (GO:0006283)3.23745472
69mitotic recombination (GO:0006312)3.22074405
70DNA-dependent DNA replication (GO:0006261)3.21620760
71negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21540924
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21540924
73negative regulation of sister chromatid segregation (GO:0033046)3.21540924
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.21540924
75regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21340669
76* cellular component biogenesis (GO:0044085)3.20973434
77folic acid-containing compound biosynthetic process (GO:0009396)3.20082568
78mitotic spindle assembly checkpoint (GO:0007094)3.20069305
79spindle assembly checkpoint (GO:0071173)3.19435088
80folic acid metabolic process (GO:0046655)3.19280826
81mitotic sister chromatid cohesion (GO:0007064)3.18854180
82spliceosomal complex assembly (GO:0000245)3.18779051
83DNA double-strand break processing (GO:0000729)3.17728226
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17038047
85SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15382333
86rRNA methylation (GO:0031167)3.14228695
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14104386
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.13897703
89mitotic spindle checkpoint (GO:0071174)3.13788400
90double-strand break repair via nonhomologous end joining (GO:0006303)3.12770332
91non-recombinational repair (GO:0000726)3.12770332
92negative regulation of DNA-dependent DNA replication (GO:2000104)3.12459069
93establishment of integrated proviral latency (GO:0075713)3.12449289
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12170433
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11028842
96DNA damage induced protein phosphorylation (GO:0006975)3.10794669
97transcription initiation from RNA polymerase I promoter (GO:0006361)3.10700446
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08579253
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08354135
100mitotic sister chromatid segregation (GO:0000070)3.07946602
101regulation of chromosome segregation (GO:0051983)3.07444063
102cotranslational protein targeting to membrane (GO:0006613)3.05836678
103pore complex assembly (GO:0046931)3.05506040
104cellular protein complex disassembly (GO:0043624)3.05385981
105protein targeting to ER (GO:0045047)3.05088852
106telomere maintenance via telomere lengthening (GO:0010833)3.04810517
107nuclear pore complex assembly (GO:0051292)3.04310581
108regulation of mitotic spindle organization (GO:0060236)3.03231591
109viral life cycle (GO:0019058)3.01560610
110regulation of sister chromatid segregation (GO:0033045)2.99035645
111regulation of mitotic sister chromatid separation (GO:0010965)2.99035645
112regulation of mitotic sister chromatid segregation (GO:0033047)2.99035645
113DNA unwinding involved in DNA replication (GO:0006268)2.97690984
114positive regulation of mRNA 3-end processing (GO:0031442)2.97359524
115transcription elongation from RNA polymerase II promoter (GO:0006368)2.97059838
116DNA-templated transcription, termination (GO:0006353)2.96939361
117somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.95871393
118isotype switching (GO:0045190)2.95871393
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.95871393
120positive regulation of mRNA processing (GO:0050685)2.95168264
121sister chromatid segregation (GO:0000819)2.94609448
122regulation of mRNA 3-end processing (GO:0031440)2.91277456
123meiotic chromosome segregation (GO:0045132)2.88013799
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.87558034
125tRNA modification (GO:0006400)2.86744135
126replication fork processing (GO:0031297)2.85838037
127monoubiquitinated protein deubiquitination (GO:0035520)2.81245103
128regulation of centrosome cycle (GO:0046605)2.81205579
129centriole replication (GO:0007099)2.77083228
130histone mRNA metabolic process (GO:0008334)2.76531206
131regulation of translational elongation (GO:0006448)2.72656011
132mitochondrial RNA metabolic process (GO:0000959)2.71656210
133regulation of centrosome duplication (GO:0010824)2.71343519
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.70623709
135positive regulation of histone H3-K4 methylation (GO:0051571)2.67895572
136response to X-ray (GO:0010165)2.67250155
137intra-S DNA damage checkpoint (GO:0031573)2.65443800
138ncRNA processing (GO:0034470)2.64778072
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.63873659
140ubiquinone metabolic process (GO:0006743)2.62659983
141tRNA processing (GO:0008033)2.62490406
142telomere maintenance via telomerase (GO:0007004)2.62357105
143glutamine metabolic process (GO:0006541)2.61816309
144RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61798517
145IMP metabolic process (GO:0046040)2.61626964
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61431515
147somatic recombination of immunoglobulin gene segments (GO:0016447)2.61407312
148tRNA metabolic process (GO:0006399)2.61365236
149regulation of helicase activity (GO:0051095)2.59613042
150DNA topological change (GO:0006265)2.58929917
151somatic diversification of immunoglobulins (GO:0016445)2.58188842
152ncRNA metabolic process (GO:0034660)2.55950356
153positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55755563
154positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55755563
155positive regulation of mitotic sister chromatid separation (GO:1901970)2.55755563
156regulation of DNA damage checkpoint (GO:2000001)2.54420614

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.25852849
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.71207360
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.66560863
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62493116
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48022676
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44858156
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36778024
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30676001
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.29114634
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19861171
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.18741487
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.14880081
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13309908
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02283836
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97356377
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95959845
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62314971
18XRN2_22483619_ChIP-Seq_HELA_Human2.48127948
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46537687
20VDR_23849224_ChIP-Seq_CD4+_Human2.44872946
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41962787
22EWS_26573619_Chip-Seq_HEK293_Human2.33980846
23AR_21909140_ChIP-Seq_LNCAP_Human2.29993838
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25078408
25FUS_26573619_Chip-Seq_HEK293_Human2.23501023
26TAF15_26573619_Chip-Seq_HEK293_Human2.21052210
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13841396
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05464029
29DCP1A_22483619_ChIP-Seq_HELA_Human2.04230122
30TTF2_22483619_ChIP-Seq_HELA_Human2.04144677
31FOXP3_21729870_ChIP-Seq_TREG_Human2.01265418
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01241829
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99800780
34GABP_19822575_ChIP-Seq_HepG2_Human1.99702859
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96375984
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.93402568
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90778086
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88130392
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87409253
40ELK1_19687146_ChIP-ChIP_HELA_Human1.87075116
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85971971
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85970474
43ZNF274_21170338_ChIP-Seq_K562_Hela1.85577789
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.79499589
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77366340
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76405996
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72185248
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71289144
49VDR_22108803_ChIP-Seq_LS180_Human1.71283209
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70858856
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.68152410
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67707786
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62805654
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62507915
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52305469
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.52147715
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.50552767
58* KDM5A_27292631_Chip-Seq_BREAST_Human1.49008838
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47857665
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46616901
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45916589
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45477629
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.40409669
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38101775
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36166031
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35933097
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35583863
68CIITA_25753668_ChIP-Seq_RAJI_Human1.33464653
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32926594
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.30876160
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30711137
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.29212490
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25916131
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25400539
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22254283
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21266158
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19014658
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18083306
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17255924
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16576756
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16520365
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14680769
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13551537
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11900495
85P300_19829295_ChIP-Seq_ESCs_Human1.11622120
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.11103846
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10753941
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08996340
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07015097
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06470150
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05743747
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04942857
93MYC_22102868_ChIP-Seq_BL_Human1.04826433
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03958239
95* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03642243
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02527903
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02358103
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01810502
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01254755
100* TFEB_21752829_ChIP-Seq_HELA_Human1.00636010
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00632865
102MYC_18940864_ChIP-ChIP_HL60_Human1.00539636
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97553626
104BRD4_25478319_ChIP-Seq_HGPS_Human0.97500615
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.96868556
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95805083
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95158521
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94646861
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93804237
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93349786
111IGF1R_20145208_ChIP-Seq_DFB_Human0.91964160
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91110332
113* NANOG_18555785_Chip-Seq_ESCs_Mouse0.90845400
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90760473
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.90607488
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89687389
117* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89077361
118CBP_20019798_ChIP-Seq_JUKART_Human0.89042486
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89042486
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88146669
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87907907
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87220957
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87220957
124KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87220957
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.86712932
126SALL1_21062744_ChIP-ChIP_HESCs_Human0.85801490
127* PHF8_20622853_ChIP-Seq_HELA_Human0.85141040
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.84732408
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84713477
130* NFYB_21822215_ChIP-Seq_K562_Human0.84592738
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84556139
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84239750
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80491772
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80377555
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80017570
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79747311
137* NMYC_18555785_Chip-Seq_ESCs_Mouse0.79365108
138SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78229917
139NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77090448
140ZNF263_19887448_ChIP-Seq_K562_Human0.77058581
141SPI1_23547873_ChIP-Seq_NB4_Human0.76004892
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75577373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.90257632
2MP0004957_abnormal_blastocyst_morpholog4.44336689
3MP0003111_abnormal_nucleus_morphology4.37911093
4MP0010094_abnormal_chromosome_stability4.21281824
5MP0008057_abnormal_DNA_replication3.94706670
6MP0003077_abnormal_cell_cycle3.88735884
7MP0008058_abnormal_DNA_repair3.38730542
8MP0008007_abnormal_cellular_replicative3.06469760
9MP0008932_abnormal_embryonic_tissue2.83603979
10MP0009697_abnormal_copulation2.81333473
11MP0008877_abnormal_DNA_methylation2.76316994
12MP0002396_abnormal_hematopoietic_system2.48118386
13MP0003123_paternal_imprinting2.41038333
14MP0001730_embryonic_growth_arrest2.29779707
15MP0002638_abnormal_pupillary_reflex2.24466271
16MP0000350_abnormal_cell_proliferation2.18572482
17MP0003718_maternal_effect2.17766436
18MP0003786_premature_aging2.10927324
19MP0005380_embryogenesis_phenotype1.82458740
20MP0001672_abnormal_embryogenesis/_devel1.82458740
21MP0003941_abnormal_skin_development1.78956889
22MP0006292_abnormal_olfactory_placode1.78581023
23MP0001697_abnormal_embryo_size1.71102791
24MP0001188_hyperpigmentation1.63307246
25MP0003984_embryonic_growth_retardation1.62450980
26MP0003950_abnormal_plasma_membrane1.60581523
27MP0002088_abnormal_embryonic_growth/wei1.59147453
28MP0002085_abnormal_embryonic_tissue1.57578728
29MP0002080_prenatal_lethality1.51117702
30MP0010030_abnormal_orbit_morphology1.50148907
31MP0010352_gastrointestinal_tract_polyps1.48493375
32MP0010307_abnormal_tumor_latency1.47587944
33MP0002084_abnormal_developmental_patter1.46427386
34MP0002210_abnormal_sex_determination1.46250977
35MP0002009_preneoplasia1.37476581
36MP0009046_muscle_twitch1.36082178
37MP0001502_abnormal_circadian_rhythm1.34330790
38MP0000313_abnormal_cell_death1.33168810
39MP0000569_abnormal_digit_pigmentation1.31242501
40MP0009333_abnormal_splenocyte_physiolog1.30661274
41MP0003315_abnormal_perineum_morphology1.28982773
42MP0002086_abnormal_extraembryonic_tissu1.28703126
43MP0002019_abnormal_tumor_incidence1.28115849
44MP0005076_abnormal_cell_differentiation1.25215405
45MP0004197_abnormal_fetal_growth/weight/1.25117506
46MP0000490_abnormal_crypts_of1.24475136
47MP0004808_abnormal_hematopoietic_stem1.20918722
48MP0001145_abnormal_male_reproductive1.20490024
49MP0003567_abnormal_fetal_cardiomyocyte1.19911061
50MP0001293_anophthalmia1.16612418
51MP0000372_irregular_coat_pigmentation1.12793116
52MP0001545_abnormal_hematopoietic_system1.12033685
53MP0005397_hematopoietic_system_phenotyp1.12033685
54MP0006035_abnormal_mitochondrial_morpho1.09159568
55MP0002653_abnormal_ependyma_morphology1.08458179
56MP0000653_abnormal_sex_gland1.08138425
57MP0003121_genomic_imprinting1.06327597
58MP0003890_abnormal_embryonic-extraembry1.05694118
59MP0002234_abnormal_pharynx_morphology1.05126617
60MP0000427_abnormal_hair_cycle1.02974748
61MP0009053_abnormal_anal_canal1.02846447
62MP0006276_abnormal_autonomic_nervous1.02175637
63MP0001929_abnormal_gametogenesis1.01799434
64MP0001119_abnormal_female_reproductive0.98974333
65MP0000647_abnormal_sebaceous_gland0.98067929
66MP0002160_abnormal_reproductive_system0.97917526
67MP0003937_abnormal_limbs/digits/tail_de0.96471203
68MP0000858_altered_metastatic_potential0.96050906
69MP0003119_abnormal_digestive_system0.94015434
70MP0008961_abnormal_basal_metabolism0.93748276
71MP0009379_abnormal_foot_pigmentation0.92471674
72MP0005257_abnormal_intraocular_pressure0.91486380
73MP0005084_abnormal_gallbladder_morpholo0.91190379
74MP0005187_abnormal_penis_morphology0.89300993
75MP0001727_abnormal_embryo_implantation0.89280971
76MP0004147_increased_porphyrin_level0.88089853
77MP0003943_abnormal_hepatobiliary_system0.87998257
78MP0002177_abnormal_outer_ear0.87775849
79MP0000631_abnormal_neuroendocrine_gland0.86554625
80MP0002111_abnormal_tail_morphology0.86272729
81MP0002132_abnormal_respiratory_system0.85224469
82MP0000613_abnormal_salivary_gland0.84944040
83MP0009672_abnormal_birth_weight0.84556871
84MP0001299_abnormal_eye_distance/0.84292430
85MP0002938_white_spotting0.83229430
86MP0002102_abnormal_ear_morphology0.82643619
87MP0000750_abnormal_muscle_regeneration0.82555133
88MP0003186_abnormal_redox_activity0.82471537
89MP0005253_abnormal_eye_physiology0.81293959
90MP0005623_abnormal_meninges_morphology0.81287774
91MP0006036_abnormal_mitochondrial_physio0.80571131
92MP0002163_abnormal_gland_morphology0.80044483
93MP0001879_abnormal_lymphatic_vessel0.79290699
94MP0000383_abnormal_hair_follicle0.79170985
95MP0005621_abnormal_cell_physiology0.78763533
96MP0003221_abnormal_cardiomyocyte_apopto0.78750371
97MP0005023_abnormal_wound_healing0.78243198
98MP0003755_abnormal_palate_morphology0.78080337
99MP0001286_abnormal_eye_development0.77978170
100MP0003806_abnormal_nucleotide_metabolis0.77963972
101MP0005389_reproductive_system_phenotype0.76681399
102MP0001529_abnormal_vocalization0.75776918
103MP0001919_abnormal_reproductive_system0.75624009
104MP0000627_abnormal_mammary_gland0.75623375
105MP0005384_cellular_phenotype0.74508582
106MP0000432_abnormal_head_morphology0.74430808
107MP0005645_abnormal_hypothalamus_physiol0.74124136
108MP0009703_decreased_birth_body0.72385299
109MP0000428_abnormal_craniofacial_morphol0.72185300
110MP0000703_abnormal_thymus_morphology0.71881478
111MP0002233_abnormal_nose_morphology0.71805420
112MP0002109_abnormal_limb_morphology0.71354663
113MP0004133_heterotaxia0.71213430
114MP0004264_abnormal_extraembryonic_tissu0.70673450
115MP0002736_abnormal_nociception_after0.70368276
116MP0005551_abnormal_eye_electrophysiolog0.68918739
117MP0002877_abnormal_melanocyte_morpholog0.68891534
118MP0004134_abnormal_chest_morphology0.68234866
119MP0000358_abnormal_cell_content/0.66801688
120MP0002697_abnormal_eye_size0.64900217
121MP0003861_abnormal_nervous_system0.64533499
122MP0000778_abnormal_nervous_system0.64328418
123MP0005379_endocrine/exocrine_gland_phen0.63783371
124MP0003699_abnormal_female_reproductive0.63121501
125MP0009250_abnormal_appendicular_skeleto0.62650437
126MP0003936_abnormal_reproductive_system0.62593711
127MP0002127_abnormal_cardiovascular_syste0.61690285
128MP0003763_abnormal_thymus_physiology0.61038777
129MP0002114_abnormal_axial_skeleton0.60971469
130MP0003448_altered_tumor_morphology0.60915042
131MP0005395_other_phenotype0.60750462
132MP0003938_abnormal_ear_development0.60471641
133MP0002722_abnormal_immune_system0.59204925
134MP0000049_abnormal_middle_ear0.59116698
135MP0006072_abnormal_retinal_apoptosis0.57996943
136MP0003935_abnormal_craniofacial_develop0.57727297
137MP0000516_abnormal_urinary_system0.57298182
138MP0005367_renal/urinary_system_phenotyp0.57298182
139MP0008995_early_reproductive_senescence0.57275227
140MP0002277_abnormal_respiratory_mucosa0.56287840

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.29798628
2Breast hypoplasia (HP:0003187)4.69468137
3Carpal bone hypoplasia (HP:0001498)3.98099569
4Diastasis recti (HP:0001540)3.93603333
5Patellar aplasia (HP:0006443)3.89353837
6Reticulocytopenia (HP:0001896)3.81871474
7Abnormality of cells of the erythroid lineage (HP:0012130)3.78819926
8Aplasia/Hypoplasia of the patella (HP:0006498)3.65844862
9Abnormal number of erythroid precursors (HP:0012131)3.64122012
10Chromsome breakage (HP:0040012)3.59097874
11Rough bone trabeculation (HP:0100670)3.46972223
12Degeneration of anterior horn cells (HP:0002398)3.42955005
13Abnormality of the anterior horn cell (HP:0006802)3.42955005
14Volvulus (HP:0002580)3.40416182
15Impulsivity (HP:0100710)3.27180334
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12393260
17Trismus (HP:0000211)3.06230544
18Oral leukoplakia (HP:0002745)3.05982208
19Cerebral hypomyelination (HP:0006808)3.01112169
20Meckel diverticulum (HP:0002245)2.98701812
21Selective tooth agenesis (HP:0001592)2.97798828
22Macrocytic anemia (HP:0001972)2.96284573
23Absent radius (HP:0003974)2.94181295
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.91473414
25Abnormality of the preputium (HP:0100587)2.87607228
26Abnormality of the ileum (HP:0001549)2.78868503
27Abnormality of the labia minora (HP:0012880)2.76146576
28Absent forearm bone (HP:0003953)2.75450230
29Aplasia involving forearm bones (HP:0009822)2.75450230
30Sparse lateral eyebrow (HP:0005338)2.71178866
31Abnormal trabecular bone morphology (HP:0100671)2.68769015
32Abnormality of chromosome stability (HP:0003220)2.67035341
33Premature graying of hair (HP:0002216)2.60366779
34Absent thumb (HP:0009777)2.60152389
35Facial hemangioma (HP:0000329)2.57750726
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.56345897
37Molar tooth sign on MRI (HP:0002419)2.54642704
38Abnormality of midbrain morphology (HP:0002418)2.54642704
39Medial flaring of the eyebrow (HP:0010747)2.53266093
40Microretrognathia (HP:0000308)2.50937459
41Horseshoe kidney (HP:0000085)2.46644828
42Multiple enchondromatosis (HP:0005701)2.46316708
43Pallor (HP:0000980)2.43823525
44Secondary amenorrhea (HP:0000869)2.43050456
45Supernumerary spleens (HP:0009799)2.43044658
46Colon cancer (HP:0003003)2.40472922
47Atresia of the external auditory canal (HP:0000413)2.40039403
48Increased hepatocellular lipid droplets (HP:0006565)2.39090884
49Aplasia/Hypoplasia involving the musculature (HP:0001460)2.38800852
50Myelodysplasia (HP:0002863)2.38528078
51Sparse eyelashes (HP:0000653)2.36636992
52Abnormal spermatogenesis (HP:0008669)2.35761079
53Glossoptosis (HP:0000162)2.35129038
54Rhabdomyosarcoma (HP:0002859)2.34807353
55Neoplasm of the pancreas (HP:0002894)2.33387822
56Pancreatic cysts (HP:0001737)2.33131836
57Premature ovarian failure (HP:0008209)2.32223090
58Triphalangeal thumb (HP:0001199)2.31892386
59Hyperinsulinemic hypoglycemia (HP:0000825)2.31775008
60Increased CSF lactate (HP:0002490)2.31402791
61Acute necrotizing encephalopathy (HP:0006965)2.30736765
62Congenital primary aphakia (HP:0007707)2.26413073
63Hypothermia (HP:0002045)2.26209598
64Pancreatic fibrosis (HP:0100732)2.24400501
65Aplastic anemia (HP:0001915)2.23251533
66Lipid accumulation in hepatocytes (HP:0006561)2.21256607
67Nephronophthisis (HP:0000090)2.20418230
68Small intestinal stenosis (HP:0012848)2.20402344
69Duodenal stenosis (HP:0100867)2.20402344
70Cleft eyelid (HP:0000625)2.18638821
71Slender long bone (HP:0003100)2.15115968
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13734239
73Abnormality of alanine metabolism (HP:0010916)2.13734239
74Hyperalaninemia (HP:0003348)2.13734239
75Nephrogenic diabetes insipidus (HP:0009806)2.13106662
76Gait imbalance (HP:0002141)2.11384938
77Bifid tongue (HP:0010297)2.08925956
78Tracheoesophageal fistula (HP:0002575)2.08264718
79Distal arthrogryposis (HP:0005684)2.07499430
80Progressive macrocephaly (HP:0004481)2.06289094
81Irregular epiphyses (HP:0010582)2.04989138
82Type I transferrin isoform profile (HP:0003642)2.04515732
83Abnormal protein glycosylation (HP:0012346)2.04318240
84Abnormal glycosylation (HP:0012345)2.04318240
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04318240
86Abnormal protein N-linked glycosylation (HP:0012347)2.04318240
87Severe combined immunodeficiency (HP:0004430)2.04102711
88Abnormal lung lobation (HP:0002101)2.03557094
89Methylmalonic acidemia (HP:0002912)2.03271561
90Sloping forehead (HP:0000340)2.02116156
91Hyperventilation (HP:0002883)2.01807044
92Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01647333
93Small hand (HP:0200055)2.01622117
94Breast aplasia (HP:0100783)2.01612101
95Mitochondrial inheritance (HP:0001427)2.00511494
96Bone marrow hypocellularity (HP:0005528)2.00444206
97Spinal muscular atrophy (HP:0007269)2.00052616
98Ectopic kidney (HP:0000086)1.99346585
99Abnormality of the pons (HP:0007361)1.99209263
100Medulloblastoma (HP:0002885)1.98992000
101Progressive muscle weakness (HP:0003323)1.98253134
102Hypoplasia of the radius (HP:0002984)1.95893241
103Acute myeloid leukemia (HP:0004808)1.95209246
104Aplasia/Hypoplasia of the breasts (HP:0010311)1.94191783
105Squamous cell carcinoma (HP:0002860)1.94167481
106Abnormal number of incisors (HP:0011064)1.92811242
10711 pairs of ribs (HP:0000878)1.92343506
108Nephroblastoma (Wilms tumor) (HP:0002667)1.91170120
109Aplasia/hypoplasia of the humerus (HP:0006507)1.90764769
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.90691415
111Thin upper lip vermilion (HP:0000219)1.90557682
112Ependymoma (HP:0002888)1.90375790
113Embryonal renal neoplasm (HP:0011794)1.90018585
114Capillary hemangiomas (HP:0005306)1.89450534
115Cerebellar dysplasia (HP:0007033)1.89256694
116Proximal placement of thumb (HP:0009623)1.88753397
117Abnormality of the duodenum (HP:0002246)1.87733759
118Facial cleft (HP:0002006)1.87092874
119Acute encephalopathy (HP:0006846)1.86899323
120Short thumb (HP:0009778)1.86518597
121Fair hair (HP:0002286)1.86356157
122True hermaphroditism (HP:0010459)1.85578881
123Abnormality of the renal medulla (HP:0100957)1.85217641
124Deviation of the thumb (HP:0009603)1.83826736
125Adrenal hypoplasia (HP:0000835)1.83475289
126Entropion (HP:0000621)1.82675243
127Increased serum lactate (HP:0002151)1.82580960
128Abnormal mitochondria in muscle tissue (HP:0008316)1.82084854
129Hypoplasia of the pons (HP:0012110)1.82048565
130Poor coordination (HP:0002370)1.79686933
131Duplicated collecting system (HP:0000081)1.78367443
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.78344982
133Mesangial abnormality (HP:0001966)1.78189394
134Shawl scrotum (HP:0000049)1.78104901
135Pendular nystagmus (HP:0012043)1.77744705
136Oligodactyly (HP:0012165)1.77279097
137Prominent nasal bridge (HP:0000426)1.77243285
138Abnormality of abdominal situs (HP:0011620)1.77024002
139Abdominal situs inversus (HP:0003363)1.77024002
140Neoplasm of the adrenal cortex (HP:0100641)1.75958993
141Blepharitis (HP:0000498)1.75320341
142Attenuation of retinal blood vessels (HP:0007843)1.74763384
143Azoospermia (HP:0000027)1.74295382
144Muscle fiber atrophy (HP:0100295)1.73728681
145Ureteral duplication (HP:0000073)1.73498242
146Postnatal microcephaly (HP:0005484)1.73187585
147Respiratory difficulties (HP:0002880)1.72922202
148Combined immunodeficiency (HP:0005387)1.72445832
149CNS hypomyelination (HP:0003429)1.71846464
150Breech presentation (HP:0001623)1.71722793
151Limb dystonia (HP:0002451)1.71637283
152Decreased testicular size (HP:0008734)1.71553257
153Cerebral edema (HP:0002181)1.70911825
154Agnosia (HP:0010524)1.70531168
155Cellular immunodeficiency (HP:0005374)1.70259928
156Exertional dyspnea (HP:0002875)1.70139185
157Lissencephaly (HP:0001339)1.70003505
158Prominent metopic ridge (HP:0005487)1.69066597
159Congenital, generalized hypertrichosis (HP:0004540)1.68529178
160Aplasia/hypoplasia of the uterus (HP:0008684)1.67380520
161Abnormality of methionine metabolism (HP:0010901)1.66604140
162Oculomotor apraxia (HP:0000657)1.66062185
163Overlapping toe (HP:0001845)1.65503804
164Acute lymphatic leukemia (HP:0006721)1.64151862
165Tubular atrophy (HP:0000092)1.63027793
166Highly arched eyebrow (HP:0002553)1.62977464
167Astigmatism (HP:0000483)1.61952803
168Megaloblastic anemia (HP:0001889)1.61938418
169Prominent nose (HP:0000448)1.61852504
170Median cleft lip (HP:0000161)1.61851113
171Abnormality of the renal cortex (HP:0011035)1.61600375
172Glioma (HP:0009733)1.61158850
173Short middle phalanx of the 5th finger (HP:0004220)1.60002924
174Oligodactyly (hands) (HP:0001180)1.58527642
175Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.57203347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.45575718
2BUB14.19896799
3EIF2AK13.43969615
4CDC73.36717826
5SRPK13.30157819
6NME23.11072476
7TNIK2.78743177
8NUAK12.73446562
9BRSK22.59655358
10FRK2.49636819
11NEK22.38603741
12PLK42.31235358
13EIF2AK32.25913735
14PLK12.14646593
15TRIM282.09091121
16TTK2.08924832
17LATS22.03654536
18STK162.03295566
19MKNK11.99648606
20MKNK21.97412926
21VRK11.96900713
22PLK31.82949033
23TSSK61.81771381
24ACVR1B1.79795640
25PDK21.77506746
26TAF11.76658989
27AURKB1.72789742
28TESK21.69661877
29DYRK31.69553094
30NEK11.67417520
31CDK121.66858275
32CDK71.66838675
33TLK11.66023828
34VRK21.65185499
35BMPR1B1.63823868
36PIM21.61865975
37RPS6KA41.52631516
38EPHA21.51055942
39CHEK21.48159155
40AURKA1.46415636
41PLK21.42924952
42STK38L1.39478029
43ATR1.35917423
44PIK3CG1.35624120
45BRSK11.31457135
46RPS6KB21.26650128
47CSNK1G31.22366904
48CHEK11.18299762
49INSRR1.16379858
50MAP3K121.12881748
51CDK91.12844031
52EIF2AK21.10141972
53CDK41.06707150
54STK391.06473922
55PASK1.05829164
56CSNK1G21.04960028
57GRK11.04572334
58ZAK1.03971819
59CASK1.02592606
60CDK80.99948207
61BCR0.98775293
62STK100.98023651
63MAP3K80.92471388
64STK30.92355494
65ATM0.86711508
66LATS10.84859337
67SCYL20.84725914
68CDK20.83762580
69CAMKK20.83495788
70NME10.82738737
71WNK30.80660266
72MAP3K40.80429437
73PAK40.80192472
74PAK10.80131186
75OXSR10.78173506
76DYRK20.75875471
77CSNK2A10.73938571
78MST40.73571187
79PRKCI0.72738946
80CSNK2A20.71845271
81IRAK30.71781704
82DMPK0.71159280
83ERBB40.68074182
84STK40.68002587
85PIM10.67254631
86ALK0.66802097
87TESK10.66484133
88AKT30.64186532
89PNCK0.63509642
90IRAK40.63187684
91PBK0.62279513
92ERBB30.61456897
93CDK10.60031214
94TGFBR10.58810852
95BRAF0.58453293
96TEC0.57913919
97MAPKAPK30.57253361
98NEK90.57140654
99MELK0.57110574
100RPS6KA50.54594733
101NLK0.53768655
102CSNK1E0.53050845
103LIMK10.52901307
104CCNB10.52645269
105PRKCE0.47145548
106PAK20.47005661
107CAMK1G0.46897356
108PAK30.45298331
109SGK20.44986991
110CDK60.44819326
111ILK0.44615275
112FLT30.43006437
113MAP4K20.43004995
114SIK30.42182726
115WNK40.40022091
116MAP3K30.39925149
117STK240.39756781
118CSNK1A1L0.39645296
119ABL20.39466834
120CDK30.38476868
121MAP3K110.36708966
122LRRK20.36508519
123CSNK1A10.35089055
124RPS6KB10.35030832
125MAP2K20.32470759
126AKT20.29798057
127PRKCG0.29671939
128MTOR0.29551070
129MST1R0.29445920
130MARK30.29438839
131CSNK1G10.27241757
132IKBKB0.26850743
133CHUK0.26722231
134MAP3K50.25846007
135BRD40.25211665
136PRKDC0.24985639
137TAOK20.24455628
138MAPK140.21907530

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.46716854
2RNA polymerase_Homo sapiens_hsa030204.26814657
3DNA replication_Homo sapiens_hsa030303.99790998
4Ribosome_Homo sapiens_hsa030103.88414447
5Mismatch repair_Homo sapiens_hsa034303.54956496
6Spliceosome_Homo sapiens_hsa030403.50349230
7Proteasome_Homo sapiens_hsa030503.46902753
8RNA transport_Homo sapiens_hsa030133.46417135
9Homologous recombination_Homo sapiens_hsa034402.99998131
10Nucleotide excision repair_Homo sapiens_hsa034202.76972294
11Base excision repair_Homo sapiens_hsa034102.72176310
12Cell cycle_Homo sapiens_hsa041102.71945685
13Pyrimidine metabolism_Homo sapiens_hsa002402.63085576
14Basal transcription factors_Homo sapiens_hsa030222.58016787
15One carbon pool by folate_Homo sapiens_hsa006702.36466672
16Fanconi anemia pathway_Homo sapiens_hsa034602.29229166
17RNA degradation_Homo sapiens_hsa030182.14035697
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09408941
19mRNA surveillance pathway_Homo sapiens_hsa030151.86481869
20Non-homologous end-joining_Homo sapiens_hsa034501.82257232
21p53 signaling pathway_Homo sapiens_hsa041151.71133356
22Circadian rhythm_Homo sapiens_hsa047101.59791201
23Nitrogen metabolism_Homo sapiens_hsa009101.51744260
24Purine metabolism_Homo sapiens_hsa002301.49929493
25Vitamin B6 metabolism_Homo sapiens_hsa007501.45559782
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38696338
27Oxidative phosphorylation_Homo sapiens_hsa001901.34820623
28Epstein-Barr virus infection_Homo sapiens_hsa051691.32265222
29Propanoate metabolism_Homo sapiens_hsa006401.25047511
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14609387
31Sulfur relay system_Homo sapiens_hsa041221.07917488
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06661740
33Oocyte meiosis_Homo sapiens_hsa041141.04731314
34Folate biosynthesis_Homo sapiens_hsa007901.04267329
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99349889
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98530371
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94844862
38Pentose phosphate pathway_Homo sapiens_hsa000300.92822135
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92344101
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92129706
41Herpes simplex infection_Homo sapiens_hsa051680.85730774
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84006138
43Pyruvate metabolism_Homo sapiens_hsa006200.82376227
44Protein export_Homo sapiens_hsa030600.80445112
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.79688002
46HTLV-I infection_Homo sapiens_hsa051660.71920742
47Viral carcinogenesis_Homo sapiens_hsa052030.70988636
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.68391165
49Sulfur metabolism_Homo sapiens_hsa009200.67420885
50Antigen processing and presentation_Homo sapiens_hsa046120.64353399
51Selenocompound metabolism_Homo sapiens_hsa004500.63818963
52Huntingtons disease_Homo sapiens_hsa050160.63731565
53Biosynthesis of amino acids_Homo sapiens_hsa012300.63590428
54MicroRNAs in cancer_Homo sapiens_hsa052060.62175206
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62025827
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61772574
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.61550873
58TGF-beta signaling pathway_Homo sapiens_hsa043500.60695888
59Alzheimers disease_Homo sapiens_hsa050100.59146440
60Thyroid cancer_Homo sapiens_hsa052160.58348643
61Lysine degradation_Homo sapiens_hsa003100.56324581
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55329890
63Systemic lupus erythematosus_Homo sapiens_hsa053220.53812845
64Cocaine addiction_Homo sapiens_hsa050300.53784197
65Small cell lung cancer_Homo sapiens_hsa052220.52032839
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51938332
67Hippo signaling pathway_Homo sapiens_hsa043900.50607105
68Phototransduction_Homo sapiens_hsa047440.50119263
69Glutathione metabolism_Homo sapiens_hsa004800.48318680
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45902805
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45690740
72Ether lipid metabolism_Homo sapiens_hsa005650.45483616
73Butanoate metabolism_Homo sapiens_hsa006500.40523446
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38365747
75Bladder cancer_Homo sapiens_hsa052190.37984927
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34766162
77Arachidonic acid metabolism_Homo sapiens_hsa005900.34685018
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33925619
79Primary immunodeficiency_Homo sapiens_hsa053400.32814649
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32597881
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32439931
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31900770
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29774788
84Regulation of autophagy_Homo sapiens_hsa041400.29553635
85Steroid biosynthesis_Homo sapiens_hsa001000.29404443
86Amphetamine addiction_Homo sapiens_hsa050310.29401969
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28327203
88Fatty acid elongation_Homo sapiens_hsa000620.28004722
89Basal cell carcinoma_Homo sapiens_hsa052170.27745423
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27100042
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26911358
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26413560
93Apoptosis_Homo sapiens_hsa042100.25716203
94Tryptophan metabolism_Homo sapiens_hsa003800.25229067
95Parkinsons disease_Homo sapiens_hsa050120.24234112
96HIF-1 signaling pathway_Homo sapiens_hsa040660.24197504
97Colorectal cancer_Homo sapiens_hsa052100.24174826
98Notch signaling pathway_Homo sapiens_hsa043300.23450518
99Hepatitis B_Homo sapiens_hsa051610.22609489
100Pathways in cancer_Homo sapiens_hsa052000.22151994
101Taste transduction_Homo sapiens_hsa047420.21653583
102Measles_Homo sapiens_hsa051620.21260211
103Nicotine addiction_Homo sapiens_hsa050330.20842561
104Adherens junction_Homo sapiens_hsa045200.20376269
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20203648
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.19936128
107Melanoma_Homo sapiens_hsa052180.19673531
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19605943
109Vitamin digestion and absorption_Homo sapiens_hsa049770.19423588
110Shigellosis_Homo sapiens_hsa051310.19175906
111Metabolic pathways_Homo sapiens_hsa011000.18608173
112Hedgehog signaling pathway_Homo sapiens_hsa043400.18269693
113Fatty acid biosynthesis_Homo sapiens_hsa000610.17629986
114Legionellosis_Homo sapiens_hsa051340.17350671
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.17002968
116Wnt signaling pathway_Homo sapiens_hsa043100.16859057
117Olfactory transduction_Homo sapiens_hsa047400.16248891
118Linoleic acid metabolism_Homo sapiens_hsa005910.14930550
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.14572893
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14043150
121Dorso-ventral axis formation_Homo sapiens_hsa043200.13651635
122mTOR signaling pathway_Homo sapiens_hsa041500.13134661
123Hematopoietic cell lineage_Homo sapiens_hsa046400.12297392
124Collecting duct acid secretion_Homo sapiens_hsa049660.12159093
125Prostate cancer_Homo sapiens_hsa052150.12101611
126Sphingolipid metabolism_Homo sapiens_hsa006000.10348412
127Influenza A_Homo sapiens_hsa051640.09564360
128N-Glycan biosynthesis_Homo sapiens_hsa005100.09525753
129Fructose and mannose metabolism_Homo sapiens_hsa000510.08241487
130Chronic myeloid leukemia_Homo sapiens_hsa052200.08241381
131Arginine and proline metabolism_Homo sapiens_hsa003300.08097735
132Carbon metabolism_Homo sapiens_hsa012000.08000642
133Tight junction_Homo sapiens_hsa045300.06783698
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06680312
135Acute myeloid leukemia_Homo sapiens_hsa052210.06402010
136Viral myocarditis_Homo sapiens_hsa054160.06247364
137Other glycan degradation_Homo sapiens_hsa005110.04240161
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.03013687
139Proteoglycans in cancer_Homo sapiens_hsa052050.02885239

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