ZNHIT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription elongation from RNA polymerase III promoter (GO:0006385)5.40941953
2termination of RNA polymerase III transcription (GO:0006386)5.40941953
3proteasome assembly (GO:0043248)5.17362478
4purine nucleobase biosynthetic process (GO:0009113)4.82644688
57-methylguanosine mRNA capping (GO:0006370)4.81143159
6rRNA modification (GO:0000154)4.80367398
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.75858512
8ATP synthesis coupled proton transport (GO:0015986)4.75858512
9RNA capping (GO:0036260)4.74557768
107-methylguanosine RNA capping (GO:0009452)4.74557768
11mitotic metaphase plate congression (GO:0007080)4.70088580
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.55840429
13DNA deamination (GO:0045006)4.49775262
14transcription elongation from RNA polymerase I promoter (GO:0006362)4.49044667
15termination of RNA polymerase I transcription (GO:0006363)4.40977950
16protein complex biogenesis (GO:0070271)4.36990051
17nucleobase biosynthetic process (GO:0046112)4.35518213
18ribosome biogenesis (GO:0042254)4.32655838
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23937450
20mitochondrial respiratory chain complex I assembly (GO:0032981)4.23937450
21NADH dehydrogenase complex assembly (GO:0010257)4.23937450
22ribosome assembly (GO:0042255)4.22145718
23transcription from RNA polymerase I promoter (GO:0006360)4.21544706
24mitochondrial respiratory chain complex assembly (GO:0033108)4.12434510
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.12120554
26DNA replication checkpoint (GO:0000076)4.10847728
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10124845
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.07994377
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.05780674
30respiratory electron transport chain (GO:0022904)3.96646103
31respiratory chain complex IV assembly (GO:0008535)3.94961337
32electron transport chain (GO:0022900)3.92447585
33ribonucleoprotein complex biogenesis (GO:0022613)3.88675572
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.85856960
35transcription initiation from RNA polymerase I promoter (GO:0006361)3.84580822
36spliceosomal snRNP assembly (GO:0000387)3.84058303
37maturation of 5.8S rRNA (GO:0000460)3.80707342
38rRNA methylation (GO:0031167)3.80507089
39maturation of SSU-rRNA (GO:0030490)3.79344906
40behavioral response to nicotine (GO:0035095)3.77212372
41chaperone-mediated protein transport (GO:0072321)3.72983201
42CENP-A containing nucleosome assembly (GO:0034080)3.72583907
43negative regulation of ligase activity (GO:0051352)3.70864975
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70864975
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.68557613
46transcription elongation from RNA polymerase II promoter (GO:0006368)3.67129595
47metaphase plate congression (GO:0051310)3.65421649
48rRNA processing (GO:0006364)3.65273779
49DNA-templated transcription, elongation (GO:0006354)3.63644432
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.60195995
51protein neddylation (GO:0045116)3.57682815
52rRNA metabolic process (GO:0016072)3.55645789
53ribosomal large subunit biogenesis (GO:0042273)3.55200387
54cytochrome complex assembly (GO:0017004)3.54800488
55protein K6-linked ubiquitination (GO:0085020)3.54165529
56regulation of cellular amino acid metabolic process (GO:0006521)3.53019612
57positive regulation of ligase activity (GO:0051351)3.52524331
58pseudouridine synthesis (GO:0001522)3.52405403
59chromatin remodeling at centromere (GO:0031055)3.52186257
60guanosine-containing compound biosynthetic process (GO:1901070)3.48107866
61transcription-coupled nucleotide-excision repair (GO:0006283)3.46494707
62cellular component biogenesis (GO:0044085)3.38079788
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37946243
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37946243
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37946243
66positive regulation of viral transcription (GO:0050434)3.37205719
67protein targeting to mitochondrion (GO:0006626)3.36649442
68ribosomal small subunit assembly (GO:0000028)3.36360247
69L-methionine salvage (GO:0071267)3.35842996
70L-methionine biosynthetic process (GO:0071265)3.35842996
71amino acid salvage (GO:0043102)3.35842996
72regulation of mitochondrial translation (GO:0070129)3.35397583
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34460435
74kinetochore assembly (GO:0051382)3.34029174
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31701174
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31701174
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31358294
78signal transduction involved in DNA damage checkpoint (GO:0072422)3.31358294
79microtubule depolymerization (GO:0007019)3.28843916
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28637413
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28637413
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.27975653
83establishment of protein localization to mitochondrion (GO:0072655)3.27580087
84regulation of spindle organization (GO:0090224)3.26279068
85positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.25946987
86blastocyst development (GO:0001824)3.25832214
87regulation of ubiquitin-protein transferase activity (GO:0051438)3.23432608
88DNA replication initiation (GO:0006270)3.23193321
89translational termination (GO:0006415)3.21684685
90cullin deneddylation (GO:0010388)3.21641450
91regulation of nuclear cell cycle DNA replication (GO:0033262)3.20562382
92ribosomal small subunit biogenesis (GO:0042274)3.19099276
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19019367
94histone exchange (GO:0043486)3.17590879
95viral transcription (GO:0019083)3.16570140
96spliceosomal complex assembly (GO:0000245)3.16341502
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16116096
98protein deneddylation (GO:0000338)3.13056148
99regulation of ligase activity (GO:0051340)3.11947982
100transcription from RNA polymerase III promoter (GO:0006383)3.10397575
101GMP metabolic process (GO:0046037)3.08727545
102protein-cofactor linkage (GO:0018065)3.07050922
103cell cycle G1/S phase transition (GO:0044843)3.05784763
104G1/S transition of mitotic cell cycle (GO:0000082)3.05784763
105DNA replication-independent nucleosome assembly (GO:0006336)3.04871786
106DNA replication-independent nucleosome organization (GO:0034724)3.04871786
107mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03822823
108DNA-templated transcription, termination (GO:0006353)3.03655646
109protein localization to mitochondrion (GO:0070585)3.03078982
110spindle checkpoint (GO:0031577)3.03056351
111establishment of chromosome localization (GO:0051303)3.00950205
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00708957
113peptidyl-histidine modification (GO:0018202)2.98965966
114regulation of double-strand break repair via homologous recombination (GO:0010569)2.98957307
115nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98426538
116cotranslational protein targeting to membrane (GO:0006613)2.98063536
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98058877
118regulation of mitotic spindle checkpoint (GO:1903504)2.98058877
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97913115
120kinetochore organization (GO:0051383)2.97795281
121DNA-dependent DNA replication (GO:0006261)2.97769590
122replication fork processing (GO:0031297)2.96918947
123water-soluble vitamin biosynthetic process (GO:0042364)2.93751792
124GTP biosynthetic process (GO:0006183)2.93683852
125RNA methylation (GO:0001510)2.90326881
126protein targeting to ER (GO:0045047)2.89173627
127hydrogen ion transmembrane transport (GO:1902600)2.84587019
128DNA double-strand break processing (GO:0000729)2.84375575
129ATP biosynthetic process (GO:0006754)2.84372008
130nonmotile primary cilium assembly (GO:0035058)2.80537246
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79886611
132establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76959214
133intracellular protein transmembrane import (GO:0044743)2.73842944
134protein localization to endoplasmic reticulum (GO:0070972)2.72833243
135translational elongation (GO:0006414)2.72793487
136platelet dense granule organization (GO:0060155)2.71709169
137DNA damage response, detection of DNA damage (GO:0042769)2.71637476
138sequestering of actin monomers (GO:0042989)2.71362116
139purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70402741
140proton transport (GO:0015992)2.69265528
141purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67574405
142regulation of cilium movement (GO:0003352)2.66744552
143translation (GO:0006412)2.65900497
144tRNA processing (GO:0008033)2.63326593
145hydrogen transport (GO:0006818)2.62726273
146recombinational repair (GO:0000725)2.60896413
147centriole replication (GO:0007099)2.60576105
148mannosylation (GO:0097502)2.58704711
149histone mRNA metabolic process (GO:0008334)2.57905172
150double-strand break repair via homologous recombination (GO:0000724)2.57411743
151indolalkylamine metabolic process (GO:0006586)2.53549084
152negative regulation of DNA-dependent DNA replication (GO:2000104)2.52797093
153inner mitochondrial membrane organization (GO:0007007)2.50275341
154translational initiation (GO:0006413)2.50073753
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49475928
156piRNA metabolic process (GO:0034587)2.48842866
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.48543880
158kynurenine metabolic process (GO:0070189)2.46576076
159anterograde synaptic vesicle transport (GO:0048490)2.45989845
160cellular protein complex disassembly (GO:0043624)2.44062441
161resolution of meiotic recombination intermediates (GO:0000712)2.43117728
162epithelial cilium movement (GO:0003351)2.41537213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.43933887
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.90242062
3E2F7_22180533_ChIP-Seq_HELA_Human4.45056189
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.19844139
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.07724176
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.92804399
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.82513688
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.75177081
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.68905546
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.56703211
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01723828
12ZNF274_21170338_ChIP-Seq_K562_Hela2.98000018
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91289891
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84987973
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.82851567
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79627002
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75381694
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75040190
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68489744
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66248211
21* VDR_23849224_ChIP-Seq_CD4+_Human2.66172800
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61611443
23* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45861237
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.40575632
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29377032
26EZH2_22144423_ChIP-Seq_EOC_Human2.28718494
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20332501
28EWS_26573619_Chip-Seq_HEK293_Human2.14392481
29* YY1_21170310_ChIP-Seq_MESCs_Mouse2.13605297
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13137416
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08688255
32DCP1A_22483619_ChIP-Seq_HELA_Human2.06776468
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.03818117
34GBX2_23144817_ChIP-Seq_PC3_Human2.01853712
35* FOXP3_21729870_ChIP-Seq_TREG_Human2.01348283
36XRN2_22483619_ChIP-Seq_HELA_Human2.00591656
37IGF1R_20145208_ChIP-Seq_DFB_Human1.99841167
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99715484
39ELK1_19687146_ChIP-ChIP_HELA_Human1.99098863
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98417534
41GABP_19822575_ChIP-Seq_HepG2_Human1.93535358
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89890243
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88977570
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88859996
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85070236
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83564388
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80396735
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80167955
49TTF2_22483619_ChIP-Seq_HELA_Human1.79261097
50P300_19829295_ChIP-Seq_ESCs_Human1.76949889
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72082219
52* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70577553
53TAF15_26573619_Chip-Seq_HEK293_Human1.70164470
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70036127
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66690884
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63492176
57* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62237151
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61151312
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51196762
60TP53_22573176_ChIP-Seq_HFKS_Human1.48206416
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46205425
62AR_21909140_ChIP-Seq_LNCAP_Human1.45997757
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44175717
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44161751
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.39028186
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36088621
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36029172
68KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35544337
69* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.34837516
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33574460
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32786044
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31834146
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31328262
74ER_23166858_ChIP-Seq_MCF-7_Human1.28740379
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.28437112
76MYC_18940864_ChIP-ChIP_HL60_Human1.24669966
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.22893205
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22742802
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22251977
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.21360196
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16296678
82CBP_20019798_ChIP-Seq_JUKART_Human1.16296678
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14723992
84RNF2_27304074_Chip-Seq_NSC_Mouse1.14293797
85NANOG_19829295_ChIP-Seq_ESCs_Human1.13614745
86SOX2_19829295_ChIP-Seq_ESCs_Human1.13614745
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.11429697
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11057109
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10794599
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.09629003
91FOXA1_25329375_ChIP-Seq_VCAP_Human1.03192698
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03192698
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02902651
94KDM5A_27292631_Chip-Seq_BREAST_Human1.02564324
95IRF1_19129219_ChIP-ChIP_H3396_Human1.01778826
96BCAT_22108803_ChIP-Seq_LS180_Human1.01213792
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99574096
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97674653
99NCOR_22424771_ChIP-Seq_293T_Human0.96928588
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96596448
101PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96503867
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95477801
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95428026
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95264473
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95264473
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95132459
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94951277
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94727924
109EZH2_27294783_Chip-Seq_NPCs_Mouse0.94328836
110ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93430840
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92782197
112* REST_21632747_ChIP-Seq_MESCs_Mouse0.92686612
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92259278
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91927987
115* TCF4_22108803_ChIP-Seq_LS180_Human0.91716869
116SALL1_21062744_ChIP-ChIP_HESCs_Human0.91705426
117AR_25329375_ChIP-Seq_VCAP_Human0.91090789
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90954691
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90671731
120SMAD4_21799915_ChIP-Seq_A2780_Human0.90532044
121ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90452086
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89793883
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86423723
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85429347
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84148892
126ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84072869
127* SOX17_20123909_ChIP-Seq_XEN_Mouse0.82630979
128CIITA_25753668_ChIP-Seq_RAJI_Human0.79152409
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78543721
130SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77362683
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75888892
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75680695
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75573969
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75436476
135VDR_22108803_ChIP-Seq_LS180_Human0.72613694
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71164120
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70508726
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70330601
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.69349309
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.67151253
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.66162508
142NFE2_27457419_Chip-Seq_LIVER_Mouse0.65926994
143TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.64598186
144SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.64320266
145FUS_26573619_Chip-Seq_HEK293_Human0.64061181
146SOX2_16153702_ChIP-ChIP_HESCs_Human0.63677978
147TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.63466453
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62111924
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.62016921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.36582064
2MP0003111_abnormal_nucleus_morphology4.01228455
3MP0003718_maternal_effect3.86005893
4MP0008058_abnormal_DNA_repair3.62033206
5MP0008057_abnormal_DNA_replication3.53093421
6MP0004957_abnormal_blastocyst_morpholog3.49230300
7MP0010094_abnormal_chromosome_stability3.42416438
8MP0003077_abnormal_cell_cycle3.15679771
9MP0008877_abnormal_DNA_methylation2.84395190
10MP0006292_abnormal_olfactory_placode2.83174419
11MP0008932_abnormal_embryonic_tissue2.57854585
12MP0008260_abnormal_autophagy2.53279547
13MP0003786_premature_aging2.44054082
14MP0001529_abnormal_vocalization2.31487585
15MP0002102_abnormal_ear_morphology2.14210997
16MP0008007_abnormal_cellular_replicative2.11389286
17MP0005551_abnormal_eye_electrophysiolog2.10773445
18MP0001188_hyperpigmentation2.04730333
19MP0003123_paternal_imprinting2.02532314
20MP0001986_abnormal_taste_sensitivity1.96035608
21MP0006072_abnormal_retinal_apoptosis1.92415777
22MP0003136_yellow_coat_color1.85607451
23MP0003315_abnormal_perineum_morphology1.85160681
24MP0001984_abnormal_olfaction1.73596243
25MP0003787_abnormal_imprinting1.73298262
26MP0001905_abnormal_dopamine_level1.71041800
27MP0002163_abnormal_gland_morphology1.61929854
28MP0005253_abnormal_eye_physiology1.57659641
29MP0003880_abnormal_central_pattern1.54882183
30MP0002132_abnormal_respiratory_system1.54355421
31MP0002210_abnormal_sex_determination1.54121353
32MP0009745_abnormal_behavioral_response1.53885872
33MP0009379_abnormal_foot_pigmentation1.52744689
34MP0003195_calcinosis1.52151789
35MP0005646_abnormal_pituitary_gland1.48725497
36MP0002837_dystrophic_cardiac_calcinosis1.48071392
37MP0003938_abnormal_ear_development1.45389700
38MP0000631_abnormal_neuroendocrine_gland1.44274526
39MP0001929_abnormal_gametogenesis1.40053801
40MP0002160_abnormal_reproductive_system1.39526173
41MP0002653_abnormal_ependyma_morphology1.39148576
42MP0002638_abnormal_pupillary_reflex1.36404793
43MP0002277_abnormal_respiratory_mucosa1.34379852
44MP0001730_embryonic_growth_arrest1.33682008
45MP0005645_abnormal_hypothalamus_physiol1.32169092
46MP0009333_abnormal_splenocyte_physiolog1.31260583
47MP0001293_anophthalmia1.30826610
48MP0001145_abnormal_male_reproductive1.28637653
49MP0002234_abnormal_pharynx_morphology1.28394382
50MP0003011_delayed_dark_adaptation1.27047879
51MP0008872_abnormal_physiological_respon1.26593208
52MP0005084_abnormal_gallbladder_morpholo1.24243528
53MP0005171_absent_coat_pigmentation1.24238974
54MP0001661_extended_life_span1.21859525
55MP0003890_abnormal_embryonic-extraembry1.20698881
56MP0005389_reproductive_system_phenotype1.20128782
57MP0000653_abnormal_sex_gland1.19056364
58MP0000350_abnormal_cell_proliferation1.18935705
59MP0005395_other_phenotype1.17540471
60MP0003941_abnormal_skin_development1.15572264
61MP0006035_abnormal_mitochondrial_morpho1.15410916
62MP0004133_heterotaxia1.14668926
63MP0004145_abnormal_muscle_electrophysio1.14432221
64MP0005377_hearing/vestibular/ear_phenot1.11319022
65MP0003878_abnormal_ear_physiology1.11319022
66MP0003698_abnormal_male_reproductive1.10646951
67MP0002396_abnormal_hematopoietic_system1.10385939
68MP0001501_abnormal_sleep_pattern1.10013299
69MP0000569_abnormal_digit_pigmentation1.09412735
70MP0003806_abnormal_nucleotide_metabolis1.08417310
71MP0005410_abnormal_fertilization1.05022028
72MP0001542_abnormal_bone_strength1.03417062
73MP0003879_abnormal_hair_cell1.02647290
74MP0003119_abnormal_digestive_system1.02343147
75MP0002557_abnormal_social/conspecific_i1.02288848
76MP0000778_abnormal_nervous_system1.01602779
77MP0006276_abnormal_autonomic_nervous1.01404460
78MP0006036_abnormal_mitochondrial_physio1.01217509
79MP0000372_irregular_coat_pigmentation1.00726243
80MP0000427_abnormal_hair_cycle1.00658197
81MP0001324_abnormal_eye_pigmentation1.00558591
82MP0005174_abnormal_tail_pigmentation0.99867389
83MP0005379_endocrine/exocrine_gland_phen0.99738097
84MP0002067_abnormal_sensory_capabilities0.99677781
85MP0008875_abnormal_xenobiotic_pharmacok0.99666183
86MP0005195_abnormal_posterior_eye0.99344183
87MP0001485_abnormal_pinna_reflex0.99096651
88MP0003122_maternal_imprinting0.98470013
89MP0002064_seizures0.98296040
90MP0004147_increased_porphyrin_level0.98114890
91MP0005423_abnormal_somatic_nervous0.97507633
92MP0001440_abnormal_grooming_behavior0.96835514
93MP0003567_abnormal_fetal_cardiomyocyte0.96608781
94MP0000015_abnormal_ear_pigmentation0.96248925
95MP0004381_abnormal_hair_follicle0.95849398
96MP0002938_white_spotting0.95105479
97MP0002572_abnormal_emotion/affect_behav0.94866860
98MP0000049_abnormal_middle_ear0.94844006
99MP0008995_early_reproductive_senescence0.94742310
100MP0003646_muscle_fatigue0.94501607
101MP0002876_abnormal_thyroid_physiology0.94422195
102MP0004924_abnormal_behavior0.93661535
103MP0005386_behavior/neurological_phenoty0.93661535
104MP0010386_abnormal_urinary_bladder0.93514201
105MP0003121_genomic_imprinting0.91783399
106MP0010030_abnormal_orbit_morphology0.91035874
107MP0001727_abnormal_embryo_implantation0.89579514
108MP0009046_muscle_twitch0.88861634
109MP0002734_abnormal_mechanical_nocicepti0.88548290
110MP0005380_embryogenesis_phenotype0.87607656
111MP0001672_abnormal_embryogenesis/_devel0.87607656
112MP0001919_abnormal_reproductive_system0.85223423
113MP0001764_abnormal_homeostasis0.84496048
114MP0000313_abnormal_cell_death0.84403759
115MP0000566_synostosis0.83606245
116MP0002736_abnormal_nociception_after0.83532669
117MP0004142_abnormal_muscle_tone0.81096906
118MP0008789_abnormal_olfactory_epithelium0.80739525
119MP0001119_abnormal_female_reproductive0.80697959
120MP0005451_abnormal_body_composition0.80022162
121MP0004742_abnormal_vestibular_system0.79616732
122MP0002080_prenatal_lethality0.79114569
123MP0002735_abnormal_chemical_nociception0.78892721
124MP0005408_hypopigmentation0.78548847
125MP0003186_abnormal_redox_activity0.78378867
126MP0009697_abnormal_copulation0.77229005
127MP0001697_abnormal_embryo_size0.76700448
128MP0002161_abnormal_fertility/fecundity0.76651003
129MP0001963_abnormal_hearing_physiology0.74971090
130MP0002272_abnormal_nervous_system0.73989882
131MP0002095_abnormal_skin_pigmentation0.72752042
132MP0003937_abnormal_limbs/digits/tail_de0.72034894
133MP0000026_abnormal_inner_ear0.71310686
134MP0005409_darkened_coat_color0.70291598
135MP0001968_abnormal_touch/_nociception0.70262441
136MP0005075_abnormal_melanosome_morpholog0.69574527
137MP0002751_abnormal_autonomic_nervous0.68073160
138MP0002085_abnormal_embryonic_tissue0.67922565
139MP0001486_abnormal_startle_reflex0.67385925
140MP0000358_abnormal_cell_content/0.66732605
141MP0002752_abnormal_somatic_nervous0.61912621
142MP0005499_abnormal_olfactory_system0.60023377
143MP0005394_taste/olfaction_phenotype0.60023377

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.18754774
2Breast hypoplasia (HP:0003187)4.63217078
3Cerebral hypomyelination (HP:0006808)4.37791109
4Carpal bone hypoplasia (HP:0001498)3.75600783
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.66714978
6Chromsome breakage (HP:0040012)3.34218463
7Molar tooth sign on MRI (HP:0002419)3.32459556
8Abnormality of midbrain morphology (HP:0002418)3.32459556
9Impulsivity (HP:0100710)3.25118116
103-Methylglutaconic aciduria (HP:0003535)3.23932898
11Rough bone trabeculation (HP:0100670)3.21673487
12Patellar aplasia (HP:0006443)3.09618445
13Abnormality of the preputium (HP:0100587)3.03915283
14True hermaphroditism (HP:0010459)3.02853976
15Acute necrotizing encephalopathy (HP:0006965)3.01863313
16Aplasia/Hypoplasia of the patella (HP:0006498)3.00361903
17Medial flaring of the eyebrow (HP:0010747)2.96123845
18Mitochondrial inheritance (HP:0001427)2.92154582
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91251630
20Meckel diverticulum (HP:0002245)2.90166775
21Abnormality of the labia minora (HP:0012880)2.87651797
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.86699254
23Congenital stationary night blindness (HP:0007642)2.82463486
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81522996
25Increased hepatocellular lipid droplets (HP:0006565)2.80724794
26Absent radius (HP:0003974)2.79748308
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.76780659
28Pancreatic fibrosis (HP:0100732)2.71968798
29Abnormality of the ileum (HP:0001549)2.70084890
30CNS hypomyelination (HP:0003429)2.69105615
31Increased CSF lactate (HP:0002490)2.67056912
32Aplasia involving forearm bones (HP:0009822)2.63551139
33Absent forearm bone (HP:0003953)2.63551139
34Nephronophthisis (HP:0000090)2.60210887
35Delusions (HP:0000746)2.60203050
36Cerebral edema (HP:0002181)2.59394901
37Hepatocellular necrosis (HP:0001404)2.58064787
38Abnormality of cells of the erythroid lineage (HP:0012130)2.55568746
39Gait imbalance (HP:0002141)2.53534806
40Reticulocytopenia (HP:0001896)2.53170879
41Colon cancer (HP:0003003)2.51286661
42Abnormal mitochondria in muscle tissue (HP:0008316)2.49756998
43Abnormal trabecular bone morphology (HP:0100671)2.48664268
44Oral leukoplakia (HP:0002745)2.48101289
45Congenital primary aphakia (HP:0007707)2.47806887
46Optic disc pallor (HP:0000543)2.46077162
47Aplasia/Hypoplasia involving the musculature (HP:0001460)2.43937492
48Horseshoe kidney (HP:0000085)2.42664384
49Progressive macrocephaly (HP:0004481)2.42566401
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.41414837
51Increased serum lactate (HP:0002151)2.41411642
52Abnormal number of erythroid precursors (HP:0012131)2.39816002
53Secondary amenorrhea (HP:0000869)2.39758215
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39742680
55Abnormality of alanine metabolism (HP:0010916)2.39742680
56Hyperalaninemia (HP:0003348)2.39742680
57Duplicated collecting system (HP:0000081)2.39555719
58Aplasia/hypoplasia of the uterus (HP:0008684)2.36529894
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31896852
60Increased serum pyruvate (HP:0003542)2.29575813
61Abnormality of glycolysis (HP:0004366)2.29575813
62Abnormality of chromosome stability (HP:0003220)2.29384553
63Abnormal spermatogenesis (HP:0008669)2.27756229
64Pancreatic cysts (HP:0001737)2.27724728
65Renal Fanconi syndrome (HP:0001994)2.27168571
66Nephrogenic diabetes insipidus (HP:0009806)2.27154252
67Pendular nystagmus (HP:0012043)2.26403163
68Sclerocornea (HP:0000647)2.25940699
69Respiratory difficulties (HP:0002880)2.25311323
70Type II lissencephaly (HP:0007260)2.24136590
71Macrocytic anemia (HP:0001972)2.22957584
72Ureteral duplication (HP:0000073)2.22954618
73Premature graying of hair (HP:0002216)2.22386737
74Bone marrow hypocellularity (HP:0005528)2.22010840
75Irregular epiphyses (HP:0010582)2.20946379
76Lipid accumulation in hepatocytes (HP:0006561)2.19292980
77Acute encephalopathy (HP:0006846)2.17971699
78Abnormality of the renal cortex (HP:0011035)2.17494102
79Abnormality of the renal medulla (HP:0100957)2.16951359
80Genital tract atresia (HP:0001827)2.16609467
81Methylmalonic aciduria (HP:0012120)2.15737388
82Type 2 muscle fiber atrophy (HP:0003554)2.15388133
83Methylmalonic acidemia (HP:0002912)2.14504432
84Hypoplasia of the pons (HP:0012110)2.10628251
85Vaginal atresia (HP:0000148)2.10539986
86Triphalangeal thumb (HP:0001199)2.09677980
87Premature ovarian failure (HP:0008209)2.09633687
88Exertional dyspnea (HP:0002875)2.08660494
89Abnormality of the renal collecting system (HP:0004742)2.08199955
90Anencephaly (HP:0002323)2.08002859
91Absent thumb (HP:0009777)2.07797285
92Chronic hepatic failure (HP:0100626)2.06940406
93Duodenal stenosis (HP:0100867)2.05682812
94Small intestinal stenosis (HP:0012848)2.05682812
95Unsteady gait (HP:0002317)2.04862914
96Abnormality of the pons (HP:0007361)2.04750882
97Attenuation of retinal blood vessels (HP:0007843)2.04515976
98External ophthalmoplegia (HP:0000544)2.04470825
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.04236379
100Hyperglycinemia (HP:0002154)2.04076464
101Cleft eyelid (HP:0000625)2.03081859
102CNS demyelination (HP:0007305)2.02432985
103Increased intramyocellular lipid droplets (HP:0012240)2.02314690
104Abolished electroretinogram (ERG) (HP:0000550)2.01991846
105Hepatic necrosis (HP:0002605)2.01460588
106Aplasia/Hypoplasia of the tibia (HP:0005772)2.01031227
107Optic nerve hypoplasia (HP:0000609)1.99011435
108Microvesicular hepatic steatosis (HP:0001414)1.98643598
109Sparse eyelashes (HP:0000653)1.97653862
110Leukodystrophy (HP:0002415)1.97515622
111Hypothermia (HP:0002045)1.97189789
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94506641
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94356425
114Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94356425
115Respiratory failure (HP:0002878)1.93893516
116Facial cleft (HP:0002006)1.93445495
117Breast aplasia (HP:0100783)1.93044085
118Muscle fiber atrophy (HP:0100295)1.92836724
119Progressive muscle weakness (HP:0003323)1.92588976
120Abnormality of the anterior horn cell (HP:0006802)1.91196475
121Degeneration of anterior horn cells (HP:0002398)1.91196475
122Renal cortical cysts (HP:0000803)1.90907792
123Supernumerary spleens (HP:0009799)1.89956690
124Septo-optic dysplasia (HP:0100842)1.88868666
125Retinal dysplasia (HP:0007973)1.88205676
126Cystic liver disease (HP:0006706)1.87653778
127Progressive external ophthalmoplegia (HP:0000590)1.87580262
128Aplasia/Hypoplasia of the breasts (HP:0010311)1.84898748
129Aplasia/Hypoplasia of the earlobes (HP:0009906)1.82850801
130Concave nail (HP:0001598)1.82821372
131Lactic acidosis (HP:0003128)1.82213199
132Absent epiphyses (HP:0010577)1.82053991
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82053991
134Congenital, generalized hypertrichosis (HP:0004540)1.81988187
135Exercise intolerance (HP:0003546)1.81735520
136Adrenal hypoplasia (HP:0000835)1.80814514
137Lissencephaly (HP:0001339)1.79980025
138Anophthalmia (HP:0000528)1.79528208
139Male pseudohermaphroditism (HP:0000037)1.78179516
140Lethargy (HP:0001254)1.77300916
141Abnormal respiratory epithelium morphology (HP:0012253)1.76968839
142Abnormal respiratory motile cilium morphology (HP:0005938)1.76968839
143Conical tooth (HP:0000698)1.76329325
144Preaxial hand polydactyly (HP:0001177)1.75700568
145Dysautonomia (HP:0002459)1.75513990
146Inability to walk (HP:0002540)1.74826123
147Broad-based gait (HP:0002136)1.74809892
148Postaxial foot polydactyly (HP:0001830)1.74225936
149Abnormal biliary tract physiology (HP:0012439)1.73629434
150Bile duct proliferation (HP:0001408)1.73629434
151Limb dystonia (HP:0002451)1.73142268
152Oligodactyly (hands) (HP:0001180)1.72215705
153Abnormality of renal resorption (HP:0011038)1.71056705
154Gaze-evoked nystagmus (HP:0000640)1.70739511
155Type I transferrin isoform profile (HP:0003642)1.68990202
156Bony spicule pigmentary retinopathy (HP:0007737)1.67849817
157Poor coordination (HP:0002370)1.67696741
158Postaxial hand polydactyly (HP:0001162)1.67688356
159Stenosis of the external auditory canal (HP:0000402)1.67525225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.19246752
2STK163.86470986
3FRK3.72559818
4WEE13.72047971
5PLK43.28027313
6EIF2AK13.14336044
7SRPK13.04262419
8NUAK12.67877097
9VRK22.54899906
10MAP4K22.50197382
11BRSK22.38230959
12AKT32.30357799
13ZAK2.27608438
14TSSK62.26198890
15EIF2AK32.24984709
16NME22.10396869
17PLK32.07128723
18MKNK21.96588846
19IRAK31.94480071
20VRK11.91271055
21PNCK1.90869631
22NME11.88868174
23CCNB11.84651495
24TRIM281.79186822
25PLK11.71435013
26CASK1.70885725
27MKNK11.65510447
28TTK1.65068676
29MAP3K41.56724567
30BRSK11.48701861
31ARAF1.41160556
32WNK41.36952341
33INSRR1.35746316
34PINK11.33658519
35EIF2AK21.32377500
36BRAF1.30728244
37NEK21.22764290
38CHEK21.22619028
39CDC71.20715506
40TLK11.18047548
41BCKDK1.16320894
42PIM21.14865936
43EPHA21.11209866
44DYRK21.09981800
45PASK1.09697620
46AURKA1.09623683
47ACVR1B1.07300656
48AURKB1.04419882
49NEK61.03212182
50DYRK30.99973556
51STK38L0.98947732
52CDK30.98658197
53TESK20.97491850
54PBK0.92567989
55PDK20.90015836
56TGFBR10.89442541
57MAP3K120.83523044
58MARK10.83225091
59ERBB30.81376747
60TAF10.78958684
61PLK20.78506338
62IRAK40.72399381
63CDK70.71486465
64ADRBK20.70116497
65MAP2K70.68792070
66PDK30.68364045
67PDK40.68364045
68ADRBK10.68034420
69CHEK10.67162987
70MST40.66903692
71EPHA40.66088109
72PAK30.64202847
73ATR0.63947854
74PRKCI0.63583978
75BCR0.62833271
76OXSR10.61810864
77CSNK2A10.61757464
78CDK80.61541771
79CSNK1G30.61251449
80PRKCE0.60216714
81MUSK0.56592568
82NEK10.56547302
83LIMK10.56444837
84GRK70.54399776
85TAOK30.53837171
86CSNK2A20.53016269
87LATS20.52853333
88IRAK20.52426925
89ABL20.52411605
90RPS6KA50.51219489
91PKN10.50944382
92BMPR1B0.50785544
93BMPR20.49953133
94MAPKAPK50.49825715
95PAK10.49181254
96NTRK20.48953383
97TXK0.47569361
98CAMK2A0.46951133
99GRK50.44523494
100DAPK20.43820899
101MINK10.43176517
102CAMK2B0.42118343
103MAPK130.41745344
104CDK190.41665230
105OBSCN0.41325948
106PRKACA0.40003287
107CDK10.38187230
108PHKG20.37354473
109PHKG10.37354473
110WNK30.37008537
111STK390.36969366
112TNIK0.36934889
113TIE10.36934324
114CSNK1G10.36924235
115CAMK10.36135974
116CDK20.36016947
117ATM0.35513557
118CAMK2G0.35460964
119PRKCG0.35255647
120YES10.35218882
121CSNK1D0.34648782
122CSNK1A1L0.33739059
123GRK10.31058393
124CSNK1E0.30877861
125STK240.30722976
126CAMKK20.28208819
127CSNK1G20.28145411
128STK40.26239493
129MARK30.25093233
130CSNK1A10.24977430
131RPS6KA40.24679410

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030205.20130251
2Proteasome_Homo sapiens_hsa030504.61088138
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.04196566
4Vitamin B6 metabolism_Homo sapiens_hsa007503.95762234
5Ribosome_Homo sapiens_hsa030103.34384799
6Pyrimidine metabolism_Homo sapiens_hsa002402.85917127
7DNA replication_Homo sapiens_hsa030302.84600464
8RNA transport_Homo sapiens_hsa030132.68566119
9Spliceosome_Homo sapiens_hsa030402.62757589
10Basal transcription factors_Homo sapiens_hsa030222.60139115
11Homologous recombination_Homo sapiens_hsa034402.55685153
12Mismatch repair_Homo sapiens_hsa034302.55288402
13Oxidative phosphorylation_Homo sapiens_hsa001902.51025787
14Fanconi anemia pathway_Homo sapiens_hsa034602.32960495
15Nucleotide excision repair_Homo sapiens_hsa034202.21056247
16Cell cycle_Homo sapiens_hsa041102.05693056
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03818283
18Parkinsons disease_Homo sapiens_hsa050122.02963013
19Purine metabolism_Homo sapiens_hsa002301.92353290
20Huntingtons disease_Homo sapiens_hsa050161.92103981
21Base excision repair_Homo sapiens_hsa034101.80151304
22Protein export_Homo sapiens_hsa030601.65943179
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62489917
24Butanoate metabolism_Homo sapiens_hsa006501.58761559
25Regulation of autophagy_Homo sapiens_hsa041401.57769051
26RNA degradation_Homo sapiens_hsa030181.57591423
27Propanoate metabolism_Homo sapiens_hsa006401.47012735
28Alzheimers disease_Homo sapiens_hsa050101.31824611
29Non-homologous end-joining_Homo sapiens_hsa034501.28982143
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28408885
31p53 signaling pathway_Homo sapiens_hsa041151.27492960
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25481166
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19470474
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18870675
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17764307
36Epstein-Barr virus infection_Homo sapiens_hsa051691.17460365
37Collecting duct acid secretion_Homo sapiens_hsa049661.15546343
38Nitrogen metabolism_Homo sapiens_hsa009101.10615629
39Tryptophan metabolism_Homo sapiens_hsa003801.09161624
40mRNA surveillance pathway_Homo sapiens_hsa030151.04387365
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02430378
42Oocyte meiosis_Homo sapiens_hsa041141.02089646
43Folate biosynthesis_Homo sapiens_hsa007900.99210589
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98870484
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98694910
46Selenocompound metabolism_Homo sapiens_hsa004500.97957218
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96403102
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.86517024
49Caffeine metabolism_Homo sapiens_hsa002320.85061418
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82802862
51Pentose phosphate pathway_Homo sapiens_hsa000300.79566524
52Pyruvate metabolism_Homo sapiens_hsa006200.78772028
53Peroxisome_Homo sapiens_hsa041460.77830959
54Vitamin digestion and absorption_Homo sapiens_hsa049770.75246421
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75023711
56One carbon pool by folate_Homo sapiens_hsa006700.74365630
57Olfactory transduction_Homo sapiens_hsa047400.73915942
58Phototransduction_Homo sapiens_hsa047440.73357804
59Chemical carcinogenesis_Homo sapiens_hsa052040.71038581
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69299719
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.69119040
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68449912
63Morphine addiction_Homo sapiens_hsa050320.68159543
64Nicotine addiction_Homo sapiens_hsa050330.67897709
65Arachidonic acid metabolism_Homo sapiens_hsa005900.67291582
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.67129492
67Sphingolipid metabolism_Homo sapiens_hsa006000.66636935
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66409256
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.65900579
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65436183
71GABAergic synapse_Homo sapiens_hsa047270.65424572
72Metabolic pathways_Homo sapiens_hsa011000.64395743
73Cardiac muscle contraction_Homo sapiens_hsa042600.61638138
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61562964
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61144960
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.58701566
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.57518069
78Rheumatoid arthritis_Homo sapiens_hsa053230.56627449
79Retinol metabolism_Homo sapiens_hsa008300.54301213
80Ether lipid metabolism_Homo sapiens_hsa005650.53134669
81beta-Alanine metabolism_Homo sapiens_hsa004100.50005867
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48422124
83Glutathione metabolism_Homo sapiens_hsa004800.47786955
84Linoleic acid metabolism_Homo sapiens_hsa005910.47490713
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46046316
86Sulfur metabolism_Homo sapiens_hsa009200.45182352
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44531338
88Fructose and mannose metabolism_Homo sapiens_hsa000510.40718083
89Autoimmune thyroid disease_Homo sapiens_hsa053200.39249676
90Glutamatergic synapse_Homo sapiens_hsa047240.35558776
91Basal cell carcinoma_Homo sapiens_hsa052170.34100867
92Synaptic vesicle cycle_Homo sapiens_hsa047210.34076598
93Fatty acid degradation_Homo sapiens_hsa000710.33853034
94Vibrio cholerae infection_Homo sapiens_hsa051100.33611257
95Sulfur relay system_Homo sapiens_hsa041220.32485280
96Circadian entrainment_Homo sapiens_hsa047130.31498626
97Hedgehog signaling pathway_Homo sapiens_hsa043400.30285294
98Allograft rejection_Homo sapiens_hsa053300.29954046
99Fatty acid metabolism_Homo sapiens_hsa012120.29569761
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28072178
101Fat digestion and absorption_Homo sapiens_hsa049750.25823868
102Steroid biosynthesis_Homo sapiens_hsa001000.25534384
103Arginine and proline metabolism_Homo sapiens_hsa003300.25070394
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25000036
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.23828468
106Taste transduction_Homo sapiens_hsa047420.23485106
107Systemic lupus erythematosus_Homo sapiens_hsa053220.23180275
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22647774
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22073773
110Herpes simplex infection_Homo sapiens_hsa051680.21281664
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20391172
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19480806
113Biosynthesis of amino acids_Homo sapiens_hsa012300.19144058
114Fatty acid elongation_Homo sapiens_hsa000620.18527629
115Graft-versus-host disease_Homo sapiens_hsa053320.16938488
116Circadian rhythm_Homo sapiens_hsa047100.14832132
117Asthma_Homo sapiens_hsa053100.12382506
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.11929409
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11868125
120Serotonergic synapse_Homo sapiens_hsa047260.11800520
121Viral carcinogenesis_Homo sapiens_hsa052030.11461182
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11173194
123Phagosome_Homo sapiens_hsa041450.10490656
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10181881
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.06296094
126Alcoholism_Homo sapiens_hsa050340.06233819
127Primary immunodeficiency_Homo sapiens_hsa053400.06233336
128Type I diabetes mellitus_Homo sapiens_hsa049400.04678325
129Antigen processing and presentation_Homo sapiens_hsa046120.03914005
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.03011839
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.02836172
132HTLV-I infection_Homo sapiens_hsa05166-0.0461948
133NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0448948
134Cyanoamino acid metabolism_Homo sapiens_hsa00460-0.0222133
135Amphetamine addiction_Homo sapiens_hsa05031-0.0116079

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