ZNF99

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.96847991
2fucose catabolic process (GO:0019317)4.61712037
3L-fucose metabolic process (GO:0042354)4.61712037
4L-fucose catabolic process (GO:0042355)4.61712037
5piRNA metabolic process (GO:0034587)4.33964384
6response to pheromone (GO:0019236)4.28841139
7DNA deamination (GO:0045006)4.11300749
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.73539897
9kynurenine metabolic process (GO:0070189)3.71506120
10indole-containing compound catabolic process (GO:0042436)3.70831489
11indolalkylamine catabolic process (GO:0046218)3.70831489
12tryptophan catabolic process (GO:0006569)3.70831489
13indolalkylamine metabolic process (GO:0006586)3.68525108
14water-soluble vitamin biosynthetic process (GO:0042364)3.50914355
15platelet dense granule organization (GO:0060155)3.37310012
16DNA methylation involved in gamete generation (GO:0043046)3.33215082
17synapsis (GO:0007129)3.30894286
18cellular ketone body metabolic process (GO:0046950)3.30706240
19tryptophan metabolic process (GO:0006568)3.30653726
20negative regulation of telomere maintenance (GO:0032205)3.29070687
21regulation of meiosis I (GO:0060631)3.27247430
22DNA double-strand break processing (GO:0000729)3.24010799
23neural tube formation (GO:0001841)3.23292745
24detection of light stimulus involved in visual perception (GO:0050908)3.20380416
25detection of light stimulus involved in sensory perception (GO:0050962)3.20380416
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17596990
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.17518016
28respiratory chain complex IV assembly (GO:0008535)3.17470332
29epithelial cilium movement (GO:0003351)3.15630446
30kidney morphogenesis (GO:0060993)3.14318266
31protein-cofactor linkage (GO:0018065)3.07216065
32preassembly of GPI anchor in ER membrane (GO:0016254)3.03316900
33gamma-aminobutyric acid transport (GO:0015812)3.00964166
34ketone body metabolic process (GO:1902224)2.98662286
35regulation of glucokinase activity (GO:0033131)2.91094768
36regulation of hexokinase activity (GO:1903299)2.91094768
37negative regulation of DNA-dependent DNA replication (GO:2000104)2.89328832
38sulfation (GO:0051923)2.89230632
39protein complex biogenesis (GO:0070271)2.88778521
40replication fork processing (GO:0031297)2.88579259
41RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87846963
42male meiosis I (GO:0007141)2.87159129
43recombinational repair (GO:0000725)2.84070680
44axoneme assembly (GO:0035082)2.83492680
45double-strand break repair via homologous recombination (GO:0000724)2.82618024
46cytochrome complex assembly (GO:0017004)2.82566893
47indole-containing compound metabolic process (GO:0042430)2.81775021
48protein polyglutamylation (GO:0018095)2.81644167
49photoreceptor cell maintenance (GO:0045494)2.79507663
50male meiosis (GO:0007140)2.79160001
51mitochondrial respiratory chain complex I assembly (GO:0032981)2.78992474
52NADH dehydrogenase complex assembly (GO:0010257)2.78992474
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78992474
54reciprocal meiotic recombination (GO:0007131)2.75918099
55reciprocal DNA recombination (GO:0035825)2.75918099
56nonmotile primary cilium assembly (GO:0035058)2.74370918
57positive regulation of meiosis (GO:0045836)2.72639917
58regulation of cilium movement (GO:0003352)2.71981061
59negative regulation of mast cell activation (GO:0033004)2.70355760
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69881657
61neuronal action potential (GO:0019228)2.69323898
62regulation of action potential (GO:0098900)2.68690533
63mitochondrial respiratory chain complex assembly (GO:0033108)2.67660652
64cornea development in camera-type eye (GO:0061303)2.65763169
65mannosylation (GO:0097502)2.65630898
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63200182
67negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61787781
68cilium morphogenesis (GO:0060271)2.61151442
69cellular response to ATP (GO:0071318)2.60489314
70regulation of rhodopsin mediated signaling pathway (GO:0022400)2.59440047
71protein neddylation (GO:0045116)2.58997521
72retinal cone cell development (GO:0046549)2.58848078
73ubiquinone biosynthetic process (GO:0006744)2.58767056
74protein K11-linked deubiquitination (GO:0035871)2.57347700
75protein localization to cilium (GO:0061512)2.56219713
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.53918972
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53918972
78reflex (GO:0060004)2.53417060
79positive regulation of oligodendrocyte differentiation (GO:0048714)2.53415344
80positive regulation of meiotic cell cycle (GO:0051446)2.52965124
81photoreceptor cell development (GO:0042461)2.51988759
82ubiquinone metabolic process (GO:0006743)2.51848856
83centriole replication (GO:0007099)2.50208797
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49961774
85cilium organization (GO:0044782)2.49285308
86somite rostral/caudal axis specification (GO:0032525)2.49095872
87rhodopsin mediated signaling pathway (GO:0016056)2.48954290
88G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47706543
89behavioral response to ethanol (GO:0048149)2.47447569
90cellular biogenic amine catabolic process (GO:0042402)2.47373706
91amine catabolic process (GO:0009310)2.47373706
92regulation of mesoderm development (GO:2000380)2.46980790
93adenosine metabolic process (GO:0046085)2.46851360
94adaptation of signaling pathway (GO:0023058)2.45456058
95multicellular organism reproduction (GO:0032504)2.45164020
96auditory receptor cell stereocilium organization (GO:0060088)2.44254364
97rRNA catabolic process (GO:0016075)2.44013997
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43606580
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43606580
100cilium movement (GO:0003341)2.41353233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.88798344
2VDR_22108803_ChIP-Seq_LS180_Human3.54463348
3IGF1R_20145208_ChIP-Seq_DFB_Human2.86810237
4GBX2_23144817_ChIP-Seq_PC3_Human2.85977548
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58297044
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56300020
7EZH2_22144423_ChIP-Seq_EOC_Human2.49013268
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47980099
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.43669014
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34440694
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27106545
12EWS_26573619_Chip-Seq_HEK293_Human2.16526717
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12476927
14P300_19829295_ChIP-Seq_ESCs_Human2.11539727
15FUS_26573619_Chip-Seq_HEK293_Human2.11447998
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.03242887
17* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98796385
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98388135
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98092242
20* TAF15_26573619_Chip-Seq_HEK293_Human1.94237847
21ER_23166858_ChIP-Seq_MCF-7_Human1.85775424
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85657656
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.81507882
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.74589163
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73346733
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69939778
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69786036
28BCAT_22108803_ChIP-Seq_LS180_Human1.64655466
29TP53_22573176_ChIP-Seq_HFKS_Human1.61264973
30IRF1_19129219_ChIP-ChIP_H3396_Human1.60155254
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57968218
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55353995
33* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54457763
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.53412834
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47309931
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45320291
37MYC_18940864_ChIP-ChIP_HL60_Human1.45067252
38CBP_20019798_ChIP-Seq_JUKART_Human1.44544241
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44544241
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43606312
41AR_25329375_ChIP-Seq_VCAP_Human1.42444685
42STAT3_23295773_ChIP-Seq_U87_Human1.42417543
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41693710
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40150571
45SMAD4_21799915_ChIP-Seq_A2780_Human1.39374643
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39343130
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.37467551
48TCF4_23295773_ChIP-Seq_U87_Human1.37134181
49SOX2_19829295_ChIP-Seq_ESCs_Human1.37055948
50NANOG_19829295_ChIP-Seq_ESCs_Human1.37055948
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37041353
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.37041353
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.35261231
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34524751
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.33280183
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33134398
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32056156
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31116556
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30885931
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30657495
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30419299
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30419299
63TCF4_22108803_ChIP-Seq_LS180_Human1.29394356
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.27690577
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26097413
66ELK1_19687146_ChIP-ChIP_HELA_Human1.25991793
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25080431
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22718977
69REST_21632747_ChIP-Seq_MESCs_Mouse1.22245931
70RNF2_27304074_Chip-Seq_NSC_Mouse1.20784061
71RUNX2_22187159_ChIP-Seq_PCA_Human1.20783111
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18940694
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.17859450
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17541720
75NCOR_22424771_ChIP-Seq_293T_Human1.16876069
76AR_20517297_ChIP-Seq_VCAP_Human1.15747430
77VDR_23849224_ChIP-Seq_CD4+_Human1.14666315
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.14629498
79HOXB7_26014856_ChIP-Seq_BT474_Human1.14453193
80* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12435786
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.12270766
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.11392239
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11139248
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.10861439
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.09289315
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09178194
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08981620
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.07487296
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07455244
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07092446
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.05902431
92P53_22387025_ChIP-Seq_ESCs_Mouse1.05338016
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02718508
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02373219
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01347033
96CDX2_22108803_ChIP-Seq_LS180_Human1.00749182
97AR_21572438_ChIP-Seq_LNCaP_Human0.95407119
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95152236
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95135184
100P300_18555785_Chip-Seq_ESCs_Mouse0.93806049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.39763482
2MP0002102_abnormal_ear_morphology2.69735611
3MP0000569_abnormal_digit_pigmentation2.68481994
4MP0003195_calcinosis2.63421036
5MP0002837_dystrophic_cardiac_calcinosis2.52293866
6MP0005551_abnormal_eye_electrophysiolog2.47301012
7MP0001968_abnormal_touch/_nociception2.25893675
8MP0006072_abnormal_retinal_apoptosis2.18803922
9MP0006292_abnormal_olfactory_placode2.06864042
10MP0004885_abnormal_endolymph2.01124250
11MP0005646_abnormal_pituitary_gland1.99447396
12MP0002876_abnormal_thyroid_physiology1.95103456
13MP0001986_abnormal_taste_sensitivity1.94966992
14MP0003136_yellow_coat_color1.94939915
15MP0002736_abnormal_nociception_after1.93389874
16MP0003880_abnormal_central_pattern1.92707616
17MP0005645_abnormal_hypothalamus_physiol1.91745799
18MP0003787_abnormal_imprinting1.89803388
19MP0009745_abnormal_behavioral_response1.87139215
20MP0008875_abnormal_xenobiotic_pharmacok1.80178620
21MP0008872_abnormal_physiological_respon1.78617708
22MP0005253_abnormal_eye_physiology1.76826309
23MP0003646_muscle_fatigue1.71142500
24MP0004142_abnormal_muscle_tone1.68870852
25MP0009046_muscle_twitch1.68757295
26MP0002938_white_spotting1.67683864
27MP0001501_abnormal_sleep_pattern1.63438552
28MP0002272_abnormal_nervous_system1.60146809
29MP0004043_abnormal_pH_regulation1.58881830
30MP0000427_abnormal_hair_cycle1.58478991
31MP0004133_heterotaxia1.57014635
32MP0004147_increased_porphyrin_level1.53816485
33MP0002653_abnormal_ependyma_morphology1.53510549
34MP0008058_abnormal_DNA_repair1.52895937
35MP0002638_abnormal_pupillary_reflex1.50602027
36MP0000631_abnormal_neuroendocrine_gland1.48312979
37MP0005174_abnormal_tail_pigmentation1.47935518
38MP0006276_abnormal_autonomic_nervous1.47428532
39MP0005389_reproductive_system_phenotype1.45601850
40MP0001485_abnormal_pinna_reflex1.42657790
41MP0001486_abnormal_startle_reflex1.42497618
42MP0000372_irregular_coat_pigmentation1.42439716
43MP0002160_abnormal_reproductive_system1.38493098
44MP0001529_abnormal_vocalization1.36493062
45MP0003011_delayed_dark_adaptation1.34234124
46MP0010386_abnormal_urinary_bladder1.33418577
47MP0003718_maternal_effect1.33170868
48MP0002735_abnormal_chemical_nociception1.29100141
49MP0002234_abnormal_pharynx_morphology1.26594859
50MP0005084_abnormal_gallbladder_morpholo1.25800137
51MP0001984_abnormal_olfaction1.24942350
52MP0002733_abnormal_thermal_nociception1.23630700
53MP0005379_endocrine/exocrine_gland_phen1.20541681
54MP0002572_abnormal_emotion/affect_behav1.19916394
55MP0002064_seizures1.19364202
56MP0004145_abnormal_muscle_electrophysio1.18876279
57MP0001970_abnormal_pain_threshold1.17414114
58MP0002163_abnormal_gland_morphology1.17054089
59MP0002277_abnormal_respiratory_mucosa1.16650354
60MP0001919_abnormal_reproductive_system1.15921321
61MP0002254_reproductive_system_inflammat1.10472941
62MP0000383_abnormal_hair_follicle1.07961749
63MP0005075_abnormal_melanosome_morpholog1.07452093
64MP0008995_early_reproductive_senescence1.07315697
65MP0002557_abnormal_social/conspecific_i1.06792872
66MP0004924_abnormal_behavior1.05068713
67MP0005386_behavior/neurological_phenoty1.05068713
68MP0004215_abnormal_myocardial_fiber1.02121940
69MP0004742_abnormal_vestibular_system1.01614285
70MP0002095_abnormal_skin_pigmentation1.01044408
71MP0005195_abnormal_posterior_eye1.00567721
72MP0001929_abnormal_gametogenesis0.99782144
73MP0002210_abnormal_sex_determination0.97729312
74MP0003252_abnormal_bile_duct0.95880300
75MP0002751_abnormal_autonomic_nervous0.95722988
76MP0005410_abnormal_fertilization0.95653979
77MP0002138_abnormal_hepatobiliary_system0.95247516
78MP0002928_abnormal_bile_duct0.94481861
79MP0003698_abnormal_male_reproductive0.94390413
80MP0002067_abnormal_sensory_capabilities0.94150847
81MP0000647_abnormal_sebaceous_gland0.93789574
82MP0002734_abnormal_mechanical_nocicepti0.91909300
83MP0003635_abnormal_synaptic_transmissio0.89089631
84MP0003890_abnormal_embryonic-extraembry0.87526075
85MP0000653_abnormal_sex_gland0.86580416
86MP0005085_abnormal_gallbladder_physiolo0.86385969
87MP0001963_abnormal_hearing_physiology0.86075457
88MP0002063_abnormal_learning/memory/cond0.85808331
89MP0001905_abnormal_dopamine_level0.84120122
90MP0000026_abnormal_inner_ear0.83671196
91MP0003121_genomic_imprinting0.83588137
92MP0002752_abnormal_somatic_nervous0.82001882
93MP0008775_abnormal_heart_ventricle0.80323311
94MP0001145_abnormal_male_reproductive0.78994738
95MP0005332_abnormal_amino_acid0.77438416
96MP0001324_abnormal_eye_pigmentation0.77299225
97MP0002909_abnormal_adrenal_gland0.77265184
98MP0003567_abnormal_fetal_cardiomyocyte0.77048355
99MP0003137_abnormal_impulse_conducting0.77044953
100MP0000230_abnormal_systemic_arterial0.75544359

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.30799742
2Abnormality of midbrain morphology (HP:0002418)3.98335342
3Molar tooth sign on MRI (HP:0002419)3.98335342
4Pancreatic fibrosis (HP:0100732)3.94462249
5Congenital stationary night blindness (HP:0007642)3.81000308
6True hermaphroditism (HP:0010459)3.80858198
7Nephronophthisis (HP:0000090)3.77983194
8Abnormality of the renal medulla (HP:0100957)3.24448180
9Abnormality of the renal cortex (HP:0011035)3.22866700
10Medial flaring of the eyebrow (HP:0010747)2.95118517
11Type II lissencephaly (HP:0007260)2.90209884
12Abolished electroretinogram (ERG) (HP:0000550)2.88939726
13Attenuation of retinal blood vessels (HP:0007843)2.77503121
14Pendular nystagmus (HP:0012043)2.72903797
15Hyperventilation (HP:0002883)2.70132184
16Chronic hepatic failure (HP:0100626)2.64269368
17Gaze-evoked nystagmus (HP:0000640)2.61892272
18Renal cortical cysts (HP:0000803)2.60577990
19Cystic liver disease (HP:0006706)2.54518575
20Large for gestational age (HP:0001520)2.53578580
21Tubular atrophy (HP:0000092)2.51854794
22Abnormal rod and cone electroretinograms (HP:0008323)2.50905669
23Sclerocornea (HP:0000647)2.41114340
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40181182
25Abnormality of alanine metabolism (HP:0010916)2.40181182
26Hyperalaninemia (HP:0003348)2.40181182
27Inability to walk (HP:0002540)2.37702876
28Polydipsia (HP:0001959)2.36714903
29Abnormal drinking behavior (HP:0030082)2.36714903
30Keratoconus (HP:0000563)2.36043973
31Increased corneal curvature (HP:0100692)2.36043973
32Acute necrotizing encephalopathy (HP:0006965)2.27989280
33Methylmalonic acidemia (HP:0002912)2.27057526
34Progressive inability to walk (HP:0002505)2.26959331
35Increased CSF lactate (HP:0002490)2.26823848
36Furrowed tongue (HP:0000221)2.23063825
37Mitochondrial inheritance (HP:0001427)2.20319471
38Decreased central vision (HP:0007663)2.19252948
39Gait imbalance (HP:0002141)2.18892839
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.16336871
41Cerebellar dysplasia (HP:0007033)2.14523418
42Progressive macrocephaly (HP:0004481)2.12899513
43Congenital primary aphakia (HP:0007707)2.12424000
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11742006
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.11245298
46Acute encephalopathy (HP:0006846)2.09282053
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.08695217
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08354054
49Lissencephaly (HP:0001339)2.07815492
50Hyperglycinuria (HP:0003108)2.06593707
51Intestinal atresia (HP:0011100)2.06252754
52Absent/shortened dynein arms (HP:0200106)2.05529276
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.05529276
54Abnormality of the labia minora (HP:0012880)2.04759873
55Congenital, generalized hypertrichosis (HP:0004540)2.04293742
56Anencephaly (HP:0002323)2.03378028
57Hypothermia (HP:0002045)2.02938323
58Bile duct proliferation (HP:0001408)2.02504870
59Abnormal biliary tract physiology (HP:0012439)2.02504870
60Methylmalonic aciduria (HP:0012120)2.02327858
61Male pseudohermaphroditism (HP:0000037)2.01369475
62Hypoplasia of the fovea (HP:0007750)2.00823294
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.00823294
64Hepatocellular necrosis (HP:0001404)2.00700607
65Nephrogenic diabetes insipidus (HP:0009806)1.99222797
66Abnormality of the pons (HP:0007361)1.98293388
67Hepatic necrosis (HP:0002605)1.97313241
68Polyuria (HP:0000103)1.96764888
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96646613
70Congenital hepatic fibrosis (HP:0002612)1.96551946
71Optic disc pallor (HP:0000543)1.92825292
72Broad-based gait (HP:0002136)1.92136164
73Focal motor seizures (HP:0011153)1.90028094
74Aplasia/Hypoplasia of the spleen (HP:0010451)1.89043260
75Progressive cerebellar ataxia (HP:0002073)1.88781482
76Hypoplasia of the pons (HP:0012110)1.88232619
77Hemiparesis (HP:0001269)1.88082330
78Genital tract atresia (HP:0001827)1.87462929
79Hypomagnesemia (HP:0002917)1.86674587
80Ketosis (HP:0001946)1.86628942
81Optic nerve hypoplasia (HP:0000609)1.86270479
82Postaxial foot polydactyly (HP:0001830)1.83776101
83Bony spicule pigmentary retinopathy (HP:0007737)1.83662992
84Abnormality of the ileum (HP:0001549)1.83620066
85Abnormality of macular pigmentation (HP:0008002)1.82509042
86Abnormal respiratory motile cilium morphology (HP:0005938)1.82481503
87Abnormal respiratory epithelium morphology (HP:0012253)1.82481503
88Chorioretinal atrophy (HP:0000533)1.81586348
89Ketoacidosis (HP:0001993)1.80762035
90Pachygyria (HP:0001302)1.80590185
91Stomach cancer (HP:0012126)1.80570151
92Abnormal mitochondria in muscle tissue (HP:0008316)1.80224096
93Decreased circulating renin level (HP:0003351)1.80097349
94Vaginal atresia (HP:0000148)1.78594984
95Lipid accumulation in hepatocytes (HP:0006561)1.78389629
96Bilateral microphthalmos (HP:0007633)1.77370748
97Asplenia (HP:0001746)1.76517819
98Meckel diverticulum (HP:0002245)1.76236303
99Absent speech (HP:0001344)1.75808502
100Abnormality of the fovea (HP:0000493)1.74988109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.28143304
2BMPR1B3.06600970
3ADRBK23.01455848
4MAP4K22.88386631
5ZAK2.86989056
6WNK32.73784599
7GRK12.48154445
8ACVR1B2.27404882
9WNK42.22239560
10PINK12.22008893
11NUAK12.09704938
12TAOK31.93587009
13TLK11.88484325
14INSRR1.72643951
15EIF2AK31.64926260
16MAPK131.62617337
17BCKDK1.61164976
18OXSR11.59805249
19CASK1.58401407
20STK391.55051911
21TRIM281.51422540
22PNCK1.47979912
23MAP3K41.44415417
24TXK1.30626800
25CAMKK21.27928034
26MST41.27858591
27STK38L1.25110553
28VRK21.25029732
29MKNK21.19915137
30VRK11.14213562
31TGFBR11.12580693
32TNIK1.12483580
33DAPK21.09709023
34PLK21.06051148
35PAK31.03452212
36ADRBK10.96716288
37PRKCE0.94226069
38PHKG20.90480204
39PHKG10.90480204
40DYRK20.89965119
41PRKCG0.88697104
42BRSK20.87696928
43CSNK1G20.87579819
44PLK30.84420065
45CSNK1G10.83521923
46BCR0.82813595
47PLK40.80085490
48MARK10.77765947
49EPHA40.76486018
50FGFR20.75623632
51CSNK1G30.75297711
52STK160.75136308
53MAPKAPK30.74806087
54TAF10.74321967
55MAP2K70.73800623
56NTRK30.69184483
57WEE10.68452134
58TIE10.67851375
59CDK190.67364338
60ERBB30.66396973
61CSNK1A1L0.65335481
62TSSK60.63088357
63IKBKB0.62047111
64STK30.60135299
65PTK2B0.58898219
66KIT0.58624468
67TEC0.58309197
68PRKCI0.55711132
69EIF2AK20.55565215
70FLT30.54345820
71NME10.53706225
72MKNK10.52817015
73NTRK20.51842084
74CAMK2A0.51768655
75PRKCQ0.51257634
76MAP2K60.50505276
77MUSK0.44079093
78PKN10.43957813
79RPS6KA50.43288451
80GRK50.43280365
81PRKACA0.42959213
82TNK20.42841286
83CSNK1A10.42240035
84PASK0.41957983
85MAPKAPK50.41845931
86CHUK0.41303880
87PLK10.40861758
88CAMK10.39855134
89CDK80.38174257
90GRK70.37897465
91ATR0.37676453
92STK110.37655497
93CSNK1D0.35546077
94NLK0.35176005
95IRAK10.34872748
96ATM0.33158243
97CDK30.32897831
98PRKG10.32836353
99MAPK150.32335886
100PRKCA0.32154904

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.77349709
2Oxidative phosphorylation_Homo sapiens_hsa001902.41250740
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31850727
4Linoleic acid metabolism_Homo sapiens_hsa005912.26975558
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24051339
6Protein export_Homo sapiens_hsa030602.20799537
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.20363971
8Butanoate metabolism_Homo sapiens_hsa006502.12920087
9Homologous recombination_Homo sapiens_hsa034402.12336088
10Nitrogen metabolism_Homo sapiens_hsa009102.11807935
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11520789
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07614415
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02972790
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02640191
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97430797
16Basal transcription factors_Homo sapiens_hsa030221.97424056
17Selenocompound metabolism_Homo sapiens_hsa004501.96195027
18Caffeine metabolism_Homo sapiens_hsa002321.90217618
19Parkinsons disease_Homo sapiens_hsa050121.82386927
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81873651
21Nicotine addiction_Homo sapiens_hsa050331.80775842
22Fanconi anemia pathway_Homo sapiens_hsa034601.80624549
23Tryptophan metabolism_Homo sapiens_hsa003801.74556175
24Ether lipid metabolism_Homo sapiens_hsa005651.73716663
25Propanoate metabolism_Homo sapiens_hsa006401.68627824
26RNA polymerase_Homo sapiens_hsa030201.68365574
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53743721
28RNA degradation_Homo sapiens_hsa030181.42553380
29One carbon pool by folate_Homo sapiens_hsa006701.36454028
30Regulation of autophagy_Homo sapiens_hsa041401.31829174
31Olfactory transduction_Homo sapiens_hsa047401.31347817
32Taste transduction_Homo sapiens_hsa047421.31223005
33Non-homologous end-joining_Homo sapiens_hsa034501.26210031
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23009927
35Huntingtons disease_Homo sapiens_hsa050161.18828548
36Morphine addiction_Homo sapiens_hsa050321.16374589
37Cardiac muscle contraction_Homo sapiens_hsa042601.15544098
38Peroxisome_Homo sapiens_hsa041461.14986517
39Alzheimers disease_Homo sapiens_hsa050101.14571659
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11232204
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06922495
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.05444194
43Proteasome_Homo sapiens_hsa030501.00307677
44Chemical carcinogenesis_Homo sapiens_hsa052040.99602049
45Insulin secretion_Homo sapiens_hsa049110.99571127
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.99437552
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.99135213
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98321619
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98112822
50Retinol metabolism_Homo sapiens_hsa008300.93732581
51Sulfur metabolism_Homo sapiens_hsa009200.93409514
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90961984
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90537679
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90152715
55Collecting duct acid secretion_Homo sapiens_hsa049660.88248459
56Arachidonic acid metabolism_Homo sapiens_hsa005900.85893409
57Serotonergic synapse_Homo sapiens_hsa047260.84324872
58GABAergic synapse_Homo sapiens_hsa047270.84241738
59Purine metabolism_Homo sapiens_hsa002300.81606494
60Circadian entrainment_Homo sapiens_hsa047130.81371118
61ABC transporters_Homo sapiens_hsa020100.80038471
62beta-Alanine metabolism_Homo sapiens_hsa004100.79259023
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71909361
64Ovarian steroidogenesis_Homo sapiens_hsa049130.71026138
65Glutamatergic synapse_Homo sapiens_hsa047240.70784123
66Salivary secretion_Homo sapiens_hsa049700.68368723
67Primary immunodeficiency_Homo sapiens_hsa053400.68215788
68Fat digestion and absorption_Homo sapiens_hsa049750.67591827
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67432753
70Metabolic pathways_Homo sapiens_hsa011000.66604692
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64344054
72Vitamin digestion and absorption_Homo sapiens_hsa049770.62766532
73Nucleotide excision repair_Homo sapiens_hsa034200.60909373
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60773058
75Asthma_Homo sapiens_hsa053100.60545773
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.60209464
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59472595
78Pyrimidine metabolism_Homo sapiens_hsa002400.59235978
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58990566
80Sulfur relay system_Homo sapiens_hsa041220.57322934
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55455041
82Mineral absorption_Homo sapiens_hsa049780.53744775
83Fatty acid degradation_Homo sapiens_hsa000710.53685314
84Calcium signaling pathway_Homo sapiens_hsa040200.52814253
85Folate biosynthesis_Homo sapiens_hsa007900.52676624
86Circadian rhythm_Homo sapiens_hsa047100.51527585
87Histidine metabolism_Homo sapiens_hsa003400.50743010
88Type I diabetes mellitus_Homo sapiens_hsa049400.50617658
89Glycerolipid metabolism_Homo sapiens_hsa005610.49856931
90Mismatch repair_Homo sapiens_hsa034300.49466581
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48356660
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46362875
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46031874
94Dorso-ventral axis formation_Homo sapiens_hsa043200.45142642
95Steroid biosynthesis_Homo sapiens_hsa001000.41897991
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.39706158
97RNA transport_Homo sapiens_hsa030130.36968950
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35191994
99Fatty acid elongation_Homo sapiens_hsa000620.33582885
100Dopaminergic synapse_Homo sapiens_hsa047280.32884796

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