ZNF98

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)4.89118274
2piRNA metabolic process (GO:0034587)4.82895095
3synapsis (GO:0007129)4.66958567
4DNA double-strand break processing (GO:0000729)4.53800656
5male meiosis I (GO:0007141)4.50336329
6negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.46273700
7somatic diversification of immune receptors via somatic mutation (GO:0002566)4.41391794
8somatic hypermutation of immunoglobulin genes (GO:0016446)4.41391794
9regulation of retinoic acid receptor signaling pathway (GO:0048385)4.27205959
10replication fork processing (GO:0031297)4.12003881
11regulation of meiosis I (GO:0060631)3.92117710
12male meiosis (GO:0007140)3.83294965
13regulation of mitotic spindle checkpoint (GO:1903504)3.74715386
14regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.74715386
15centriole assembly (GO:0098534)3.72258359
16meiosis I (GO:0007127)3.68549696
17rRNA modification (GO:0000154)3.64924770
18regulation of centriole replication (GO:0046599)3.64691442
19sperm motility (GO:0030317)3.64244485
20reciprocal meiotic recombination (GO:0007131)3.58667438
21reciprocal DNA recombination (GO:0035825)3.58667438
22DNA deamination (GO:0045006)3.55541986
23DNA catabolic process, exonucleolytic (GO:0000738)3.49343898
24double-strand break repair via homologous recombination (GO:0000724)3.45682180
25chromatin remodeling at centromere (GO:0031055)3.44206116
26recombinational repair (GO:0000725)3.43064891
27protein polyglutamylation (GO:0018095)3.37679307
28rRNA methylation (GO:0031167)3.37373059
29histone exchange (GO:0043486)3.34063178
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.33602928
31resolution of meiotic recombination intermediates (GO:0000712)3.29759814
32acrosome reaction (GO:0007340)3.29317651
33maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28939874
34response to pheromone (GO:0019236)3.28877703
35protein localization to cilium (GO:0061512)3.25435685
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24038971
37CENP-A containing nucleosome assembly (GO:0034080)3.23860083
38protein K6-linked ubiquitination (GO:0085020)3.21561388
39intraciliary transport (GO:0042073)3.18162985
40microtubule depolymerization (GO:0007019)3.17598584
41regulation of DNA endoreduplication (GO:0032875)3.16100044
42proteasome assembly (GO:0043248)3.14344327
43seminiferous tubule development (GO:0072520)3.10881936
44meiotic nuclear division (GO:0007126)3.07831599
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06065460
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06065460
47DNA methylation involved in gamete generation (GO:0043046)3.03951968
48chromosome organization involved in meiosis (GO:0070192)2.99065867
49kinetochore assembly (GO:0051382)2.98716936
50mismatch repair (GO:0006298)2.94522174
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92642977
52spermatid development (GO:0007286)2.89873473
53sister chromatid cohesion (GO:0007062)2.89577962
54mitotic sister chromatid cohesion (GO:0007064)2.89471166
55regulation of centrosome duplication (GO:0010824)2.85590466
56multicellular organism reproduction (GO:0032504)2.83295737
57protein complex biogenesis (GO:0070271)2.82400387
58regulation of centrosome cycle (GO:0046605)2.82076437
59cell wall macromolecule catabolic process (GO:0016998)2.81958535
60meiotic cell cycle process (GO:1903046)2.79143747
61photoreceptor cell maintenance (GO:0045494)2.78937748
62kinetochore organization (GO:0051383)2.77288411
63ubiquinone biosynthetic process (GO:0006744)2.77106270
64pseudouridine synthesis (GO:0001522)2.75990109
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.75091417
66RNA destabilization (GO:0050779)2.74538955
67mannosylation (GO:0097502)2.72037247
68cell wall macromolecule metabolic process (GO:0044036)2.69570357
69respiratory chain complex IV assembly (GO:0008535)2.69137444
70meiotic chromosome segregation (GO:0045132)2.68562079
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67597834
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.67597834
73NADH dehydrogenase complex assembly (GO:0010257)2.67597834
74ubiquinone metabolic process (GO:0006743)2.66930408
75platelet dense granule organization (GO:0060155)2.66319848
76positive regulation of prostaglandin secretion (GO:0032308)2.65232968
77double-strand break repair (GO:0006302)2.64120580
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62403117
79mitochondrial respiratory chain complex assembly (GO:0033108)2.60783530
80sperm-egg recognition (GO:0035036)2.60766043
81meiotic cell cycle (GO:0051321)2.59497309
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58740180
83adenosine metabolic process (GO:0046085)2.57612196
84DNA recombination (GO:0006310)2.57036236
85regulation of helicase activity (GO:0051095)2.55725118
86detection of light stimulus involved in visual perception (GO:0050908)2.55269190
87detection of light stimulus involved in sensory perception (GO:0050962)2.55269190
88epithelial cilium movement (GO:0003351)2.54928051
89DNA ligation (GO:0006266)2.53014815
90protein prenylation (GO:0018342)2.52763816
91prenylation (GO:0097354)2.52763816
92establishment of protein localization to Golgi (GO:0072600)2.49950245
93phosphatidylethanolamine biosynthetic process (GO:0006646)2.48280450
94chaperone-mediated protein transport (GO:0072321)2.46583952
95negative regulation of translation, ncRNA-mediated (GO:0040033)2.45681931
96regulation of translation, ncRNA-mediated (GO:0045974)2.45681931
97negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.45681931
98single strand break repair (GO:0000012)2.45340623
99nucleotide-excision repair, DNA gap filling (GO:0006297)2.44271525
100somatic diversification of immunoglobulins (GO:0016445)2.44155768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.30168373
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25312669
3IGF1R_20145208_ChIP-Seq_DFB_Human3.11065635
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.07635297
5E2F7_22180533_ChIP-Seq_HELA_Human2.98577642
6VDR_22108803_ChIP-Seq_LS180_Human2.95799777
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89386018
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88501209
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.66184177
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.63399062
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59288074
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34100013
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32051100
14FUS_26573619_Chip-Seq_HEK293_Human2.22861900
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19786168
16TAF15_26573619_Chip-Seq_HEK293_Human2.16939539
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14175988
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.11833596
19EWS_26573619_Chip-Seq_HEK293_Human2.03412579
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00187808
21GBX2_23144817_ChIP-Seq_PC3_Human1.93966807
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.88452835
23P300_19829295_ChIP-Seq_ESCs_Human1.85086393
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83868886
25ELK1_19687146_ChIP-ChIP_HELA_Human1.83741056
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83588621
27VDR_23849224_ChIP-Seq_CD4+_Human1.70259016
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68993610
29IRF1_19129219_ChIP-ChIP_H3396_Human1.65407629
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62456341
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59290520
32TP53_22573176_ChIP-Seq_HFKS_Human1.51759365
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51064344
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50468681
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49710685
36CBP_20019798_ChIP-Seq_JUKART_Human1.49710685
37ER_23166858_ChIP-Seq_MCF-7_Human1.46506729
38MYC_18940864_ChIP-ChIP_HL60_Human1.44079388
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41832319
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.41523197
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.40960227
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40882889
43SOX2_19829295_ChIP-Seq_ESCs_Human1.40045708
44NANOG_19829295_ChIP-Seq_ESCs_Human1.40045708
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36053734
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32798289
47FOXP3_21729870_ChIP-Seq_TREG_Human1.32316701
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30121277
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28549447
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.27466880
51BCAT_22108803_ChIP-Seq_LS180_Human1.26838323
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24992582
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23852984
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.23547225
55SMAD4_21799915_ChIP-Seq_A2780_Human1.23480554
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.21887165
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21887165
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21607004
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21489283
60TCF4_22108803_ChIP-Seq_LS180_Human1.21394157
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20655416
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19330347
63STAT3_23295773_ChIP-Seq_U87_Human1.19204795
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18711110
65AR_25329375_ChIP-Seq_VCAP_Human1.18266814
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18205336
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16508151
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16408691
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15352754
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15199794
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14867379
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.14442285
73HOXB7_26014856_ChIP-Seq_BT474_Human1.12861204
74ETV1_20927104_ChIP-Seq_GIST48_Human1.12061788
75TCF4_23295773_ChIP-Seq_U87_Human1.11198458
76CDX2_22108803_ChIP-Seq_LS180_Human1.09169043
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09005099
78PHF8_20622853_ChIP-Seq_HELA_Human1.08731512
79RBPJ_21746931_ChIP-Seq_IB4_Human1.07939262
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07813498
81* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07614227
82NCOR_22424771_ChIP-Seq_293T_Human1.06738644
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.05429371
84RUNX2_22187159_ChIP-Seq_PCA_Human1.03976608
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03402130
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.02109709
87HTT_18923047_ChIP-ChIP_STHdh_Human1.01613388
88AR_20517297_ChIP-Seq_VCAP_Human1.01337020
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01299320
90NFYB_21822215_ChIP-Seq_K562_Human1.00845246
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97908880
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97114336
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96534918
94HNFA_21074721_ChIP-Seq_CACO-2_Human0.96464142
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.96263130
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93580039
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92128663
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92075351
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91877096
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91687229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.90463551
2MP0008058_abnormal_DNA_repair3.11821955
3MP0005410_abnormal_fertilization2.99700762
4MP0008057_abnormal_DNA_replication2.93379205
5MP0003718_maternal_effect2.91324711
6MP0010094_abnormal_chromosome_stability2.90428031
7MP0006292_abnormal_olfactory_placode2.79091122
8MP0005646_abnormal_pituitary_gland2.75285038
9MP0002837_dystrophic_cardiac_calcinosis2.70129734
10MP0003195_calcinosis2.41903909
11MP0009697_abnormal_copulation2.24917517
12MP0000372_irregular_coat_pigmentation2.20503972
13MP0001929_abnormal_gametogenesis2.13117790
14MP0002160_abnormal_reproductive_system2.11677781
15MP0002102_abnormal_ear_morphology2.03365895
16MP0006072_abnormal_retinal_apoptosis2.02239749
17MP0005075_abnormal_melanosome_morpholog2.01885406
18MP0005551_abnormal_eye_electrophysiolog1.93113510
19MP0001968_abnormal_touch/_nociception1.93003417
20MP0002736_abnormal_nociception_after1.82552383
21MP0002210_abnormal_sex_determination1.78310260
22MP0003698_abnormal_male_reproductive1.73568265
23MP0003693_abnormal_embryo_hatching1.70248090
24MP0000427_abnormal_hair_cycle1.69893570
25MP0001986_abnormal_taste_sensitivity1.63517451
26MP0000631_abnormal_neuroendocrine_gland1.59702390
27MP0005645_abnormal_hypothalamus_physiol1.55663637
28MP0005253_abnormal_eye_physiology1.52412188
29MP0001145_abnormal_male_reproductive1.52365007
30MP0002163_abnormal_gland_morphology1.52013045
31MP0005379_endocrine/exocrine_gland_phen1.49638123
32MP0000653_abnormal_sex_gland1.49531344
33MP0008872_abnormal_physiological_respon1.48807388
34MP0002938_white_spotting1.42051134
35MP0003011_delayed_dark_adaptation1.38318900
36MP0005389_reproductive_system_phenotype1.36310097
37MP0005085_abnormal_gallbladder_physiolo1.35582485
38MP0006054_spinal_hemorrhage1.29744381
39MP0010368_abnormal_lymphatic_system1.29684622
40MP0000383_abnormal_hair_follicle1.29005426
41MP0008995_early_reproductive_senescence1.27744493
42MP0009384_cardiac_valve_regurgitation1.25957942
43MP0003646_muscle_fatigue1.25645186
44MP0001485_abnormal_pinna_reflex1.24006986
45MP0005084_abnormal_gallbladder_morpholo1.23303129
46MP0003136_yellow_coat_color1.20960012
47MP0003111_abnormal_nucleus_morphology1.18598809
48MP0002751_abnormal_autonomic_nervous1.17121482
49MP0003806_abnormal_nucleotide_metabolis1.16255432
50MP0005670_abnormal_white_adipose1.15862877
51MP0004885_abnormal_endolymph1.14954279
52MP0002234_abnormal_pharynx_morphology1.13969098
53MP0001486_abnormal_startle_reflex1.12786904
54MP0004215_abnormal_myocardial_fiber1.12414835
55MP0003943_abnormal_hepatobiliary_system1.10417288
56MP0003880_abnormal_central_pattern1.10210919
57MP0000013_abnormal_adipose_tissue1.08246421
58MP0002254_reproductive_system_inflammat1.04469322
59MP0003077_abnormal_cell_cycle0.98977670
60MP0003786_premature_aging0.98578863
61MP0001119_abnormal_female_reproductive0.97201271
62MP0005395_other_phenotype0.96969093
63MP0003123_paternal_imprinting0.96162757
64MP0004147_increased_porphyrin_level0.96124710
65MP0001764_abnormal_homeostasis0.95566819
66MP0001984_abnormal_olfaction0.95456667
67MP0003121_genomic_imprinting0.95079515
68MP0002161_abnormal_fertility/fecundity0.93609672
69MP0004043_abnormal_pH_regulation0.92918637
70MP0002735_abnormal_chemical_nociception0.92898541
71MP0008932_abnormal_embryonic_tissue0.92135549
72MP0009745_abnormal_behavioral_response0.91134857
73MP0001293_anophthalmia0.91052857
74MP0005174_abnormal_tail_pigmentation0.89482906
75MP0006276_abnormal_autonomic_nervous0.89446417
76MP0002272_abnormal_nervous_system0.85360578
77MP0002277_abnormal_respiratory_mucosa0.84196879
78MP0006036_abnormal_mitochondrial_physio0.84123997
79MP0001963_abnormal_hearing_physiology0.81052362
80MP0009046_muscle_twitch0.80091670
81MP0002638_abnormal_pupillary_reflex0.79870775
82MP0004957_abnormal_blastocyst_morpholog0.79848891
83MP0001177_atelectasis0.79363499
84MP0002127_abnormal_cardiovascular_syste0.77908176
85MP0003119_abnormal_digestive_system0.76687863
86MP0003936_abnormal_reproductive_system0.76247129
87MP0008007_abnormal_cellular_replicative0.76033253
88MP0003186_abnormal_redox_activity0.75899049
89MP0010678_abnormal_skin_adnexa0.75376718
90MP0001919_abnormal_reproductive_system0.74367976
91MP0006035_abnormal_mitochondrial_morpho0.73192632
92MP0000647_abnormal_sebaceous_gland0.71428033
93MP0001666_abnormal_nutrient_absorption0.71326653
94MP0010307_abnormal_tumor_latency0.69581107
95MP0008789_abnormal_olfactory_epithelium0.69211550
96MP0008875_abnormal_xenobiotic_pharmacok0.68691645
97MP0002734_abnormal_mechanical_nocicepti0.67741448
98MP0000516_abnormal_urinary_system0.66424748
99MP0005367_renal/urinary_system_phenotyp0.66424748
100MP0001188_hyperpigmentation0.63853408

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)4.77922673
2Pancreatic cysts (HP:0001737)3.52921263
3Pancreatic fibrosis (HP:0100732)3.49905117
4Chronic hepatic failure (HP:0100626)3.34018512
5True hermaphroditism (HP:0010459)3.22397780
6Nephronophthisis (HP:0000090)3.21747014
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08350756
8Abnormality of midbrain morphology (HP:0002418)2.97256714
9Molar tooth sign on MRI (HP:0002419)2.97256714
10Abnormality of macular pigmentation (HP:0008002)2.93052056
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.90499297
12Amyotrophic lateral sclerosis (HP:0007354)2.86340083
13Chromsome breakage (HP:0040012)2.84502897
14Meckel diverticulum (HP:0002245)2.83544622
15Abnormality of the ileum (HP:0001549)2.77122308
16Volvulus (HP:0002580)2.72412278
17Broad distal phalanx of finger (HP:0009836)2.68529276
18Abnormality of the renal medulla (HP:0100957)2.60367499
19Small hand (HP:0200055)2.53192156
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.50528760
21Postaxial foot polydactyly (HP:0001830)2.46940455
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.45280462
23Pendular nystagmus (HP:0012043)2.37032400
24Carpal bone hypoplasia (HP:0001498)2.35783050
25Clubbing of toes (HP:0100760)2.33013036
26Hyperglycinuria (HP:0003108)2.32842686
27Mitochondrial inheritance (HP:0001427)2.30596618
28Abnormality of the preputium (HP:0100587)2.30315972
29Abnormality of the renal cortex (HP:0011035)2.30049263
30Attenuation of retinal blood vessels (HP:0007843)2.29203327
31Abnormality of chromosome stability (HP:0003220)2.28434363
32Abnormality of the labia minora (HP:0012880)2.28056754
33Medial flaring of the eyebrow (HP:0010747)2.26394726
34Abnormal rod and cone electroretinograms (HP:0008323)2.25652397
35Type II lissencephaly (HP:0007260)2.24925475
36Increased CSF lactate (HP:0002490)2.23106920
37Sclerocornea (HP:0000647)2.22016334
38Short tibia (HP:0005736)2.19655934
39Increased hepatocellular lipid droplets (HP:0006565)2.18496862
40Acute necrotizing encephalopathy (HP:0006965)2.18180712
41Lipid accumulation in hepatocytes (HP:0006561)2.18156620
42Tubulointerstitial abnormality (HP:0001969)2.16878143
43Male pseudohermaphroditism (HP:0000037)2.15648872
44Congenital stationary night blindness (HP:0007642)2.11390221
45Cystic liver disease (HP:0006706)2.11296080
46Severe visual impairment (HP:0001141)2.09785657
47Absent/shortened dynein arms (HP:0200106)2.08926486
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.08926486
49Sloping forehead (HP:0000340)2.08574995
50Type 2 muscle fiber atrophy (HP:0003554)2.05159534
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.04909395
52Hypoplasia of the fovea (HP:0007750)2.04909395
53Absent thumb (HP:0009777)2.03088382
54Renal Fanconi syndrome (HP:0001994)2.01002959
55Gaze-evoked nystagmus (HP:0000640)1.99839445
56Hip dysplasia (HP:0001385)1.99414626
57Acute encephalopathy (HP:0006846)1.99083176
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98850675
59Abnormality of the pons (HP:0007361)1.97951828
60Hypoplasia of the pons (HP:0012110)1.97900333
61Astigmatism (HP:0000483)1.97389391
62Abnormality of lateral ventricle (HP:0030047)1.96517443
63Small intestinal stenosis (HP:0012848)1.95259976
64Duodenal stenosis (HP:0100867)1.95259976
65Atrophy/Degeneration involving motor neurons (HP:0007373)1.94838962
66Progressive macrocephaly (HP:0004481)1.94127092
67Abnormality of the renal collecting system (HP:0004742)1.93331474
68Abnormality of the fovea (HP:0000493)1.92454302
69Hepatic necrosis (HP:0002605)1.88665215
70Glycosuria (HP:0003076)1.86375416
71Abnormality of urine glucose concentration (HP:0011016)1.86375416
72Abnormal mitochondria in muscle tissue (HP:0008316)1.85058262
73Hypothermia (HP:0002045)1.83759767
74Hepatocellular necrosis (HP:0001404)1.83487841
75Ectopic kidney (HP:0000086)1.81765858
76Anencephaly (HP:0002323)1.81529374
77Bony spicule pigmentary retinopathy (HP:0007737)1.81524339
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81119827
79Optic nerve hypoplasia (HP:0000609)1.80952150
80Renal cortical cysts (HP:0000803)1.80815124
81Hyperglycinemia (HP:0002154)1.80555828
82Abnormal spermatogenesis (HP:0008669)1.79814523
83Colon cancer (HP:0003003)1.79679644
84Azoospermia (HP:0000027)1.79049926
85Median cleft lip (HP:0000161)1.78952022
86Postaxial hand polydactyly (HP:0001162)1.78443448
87Febrile seizures (HP:0002373)1.77387080
88Decreased central vision (HP:0007663)1.76234184
89Cone-rod dystrophy (HP:0000548)1.75306515
90Abnormality of the duodenum (HP:0002246)1.74811579
91Cutaneous finger syndactyly (HP:0010554)1.74589370
92Abolished electroretinogram (ERG) (HP:0000550)1.73310555
93Increased serum lactate (HP:0002151)1.70821903
94Triphalangeal thumb (HP:0001199)1.70002669
95Abnormality of the carotid arteries (HP:0005344)1.68322623
96Abnormality of serine family amino acid metabolism (HP:0010894)1.67543938
97Abnormality of glycine metabolism (HP:0010895)1.67543938
98Rhabdomyosarcoma (HP:0002859)1.67104990
99Abnormal respiratory motile cilium physiology (HP:0012261)1.66676944
100Oligohydramnios (HP:0001562)1.66520812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.95226196
2VRK23.12825619
3EIF2AK32.99738591
4ACVR1B2.93379148
5NUAK12.91831863
6MAP4K22.76573779
7ZAK2.75412368
8PLK42.73163706
9WNK32.71923608
10STK392.51918262
11BMPR1B2.43002537
12OXSR12.39528053
13MST42.27686088
14VRK12.05668000
15INSRR2.00932079
16PNCK1.82101791
17TRIM281.75165563
18CDC71.72817069
19PLK31.64410237
20BRSK21.63514199
21WEE11.60375027
22TTK1.56005210
23TSSK61.55707772
24SRPK11.50038014
25MKNK21.31297176
26ADRBK21.30532481
27GRK11.30483064
28MKNK11.24640912
29MAPK131.16626960
30PLK11.14511548
31NEK11.14398701
32KIT1.11413669
33DYRK21.10140833
34MUSK1.09957052
35BUB11.07188107
36TAF11.05529873
37PLK21.05243403
38EIF2AK21.01529247
39EPHA40.91738965
40STK38L0.91499031
41TIE10.90674689
42BRD40.88678861
43CASK0.87899906
44PBK0.82961605
45PRKCE0.82600857
46PHKG20.81999817
47PHKG10.81999817
48AKT30.80459302
49MAPKAPK50.80364924
50TEC0.78900222
51MAPKAPK30.77749645
52MAP3K40.77384443
53BCKDK0.76316922
54FGFR20.75623695
55STK30.74714045
56STK160.73767561
57CCNB10.71593514
58CHEK20.71098106
59KDR0.70395671
60EPHA30.70217784
61ATR0.69850295
62FLT30.67712998
63PAK30.66612753
64FER0.66190955
65TLK10.63978974
66PRKCI0.62177593
67ATM0.61167510
68EIF2AK10.60617229
69PINK10.57169413
70CSNK1G10.56884787
71BRAF0.55450654
72TAOK30.55133583
73TXK0.52758223
74CSNK1G20.52514334
75CDK190.52472405
76TNIK0.51913559
77TGFBR10.50624330
78WNK10.50276956
79WNK40.50024645
80LATS10.48636693
81TNK20.46098939
82CDK70.44965474
83CHEK10.44792043
84CAMKK20.43861300
85BRSK10.42910276
86AURKB0.41362149
87PRKCG0.41243161
88PIK3CG0.40557771
89RPS6KB20.40451447
90PRKCQ0.39689046
91RPS6KA50.38798951
92GRK50.36915048
93CSNK1D0.36586463
94ERBB30.36381396
95CSNK1G30.35715067
96MAP3K120.35452571
97OBSCN0.34648679
98MAP3K20.34542172
99PRKG10.32517115
100AURKA0.32188531

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.37413675
2Fanconi anemia pathway_Homo sapiens_hsa034602.96799152
3Mismatch repair_Homo sapiens_hsa034302.84735056
4Non-homologous end-joining_Homo sapiens_hsa034502.55900165
5DNA replication_Homo sapiens_hsa030302.36370944
6RNA polymerase_Homo sapiens_hsa030202.34074940
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32758030
8Basal transcription factors_Homo sapiens_hsa030222.28705139
9Base excision repair_Homo sapiens_hsa034102.24772251
10Proteasome_Homo sapiens_hsa030502.23209682
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18795832
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00444162
13Oxidative phosphorylation_Homo sapiens_hsa001901.99861961
14Butanoate metabolism_Homo sapiens_hsa006501.88723796
15Parkinsons disease_Homo sapiens_hsa050121.82541955
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82174591
17Protein export_Homo sapiens_hsa030601.81168449
18RNA degradation_Homo sapiens_hsa030181.79072886
19Phototransduction_Homo sapiens_hsa047441.76836601
20Linoleic acid metabolism_Homo sapiens_hsa005911.72389429
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70043535
22Nitrogen metabolism_Homo sapiens_hsa009101.65014810
23RNA transport_Homo sapiens_hsa030131.63823583
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62860555
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57280088
26Huntingtons disease_Homo sapiens_hsa050161.52807462
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52123321
28One carbon pool by folate_Homo sapiens_hsa006701.48103285
29Caffeine metabolism_Homo sapiens_hsa002321.44877606
30Propanoate metabolism_Homo sapiens_hsa006401.42756110
31Nucleotide excision repair_Homo sapiens_hsa034201.37036478
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25981595
33Selenocompound metabolism_Homo sapiens_hsa004501.25582380
34Fatty acid elongation_Homo sapiens_hsa000621.25308522
35Spliceosome_Homo sapiens_hsa030401.23689430
36Pyrimidine metabolism_Homo sapiens_hsa002401.20957379
37Fatty acid metabolism_Homo sapiens_hsa012121.17365604
38Olfactory transduction_Homo sapiens_hsa047401.17336488
39Cell cycle_Homo sapiens_hsa041101.17270234
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16828602
41Regulation of autophagy_Homo sapiens_hsa041401.10855717
42Tryptophan metabolism_Homo sapiens_hsa003801.10852347
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10423572
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09496138
45Purine metabolism_Homo sapiens_hsa002301.09485151
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.08984749
47Retinol metabolism_Homo sapiens_hsa008301.08406194
48Peroxisome_Homo sapiens_hsa041461.06604841
49Ether lipid metabolism_Homo sapiens_hsa005651.06057383
50Chemical carcinogenesis_Homo sapiens_hsa052041.04926091
51Fatty acid degradation_Homo sapiens_hsa000711.04886102
52Oocyte meiosis_Homo sapiens_hsa041141.04004554
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00865171
54Nicotine addiction_Homo sapiens_hsa050331.00312424
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99303441
56Alzheimers disease_Homo sapiens_hsa050100.97110853
57Cardiac muscle contraction_Homo sapiens_hsa042600.94872425
58Taste transduction_Homo sapiens_hsa047420.92553997
59Sulfur metabolism_Homo sapiens_hsa009200.92531760
60Glutathione metabolism_Homo sapiens_hsa004800.89267930
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.83033854
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78794409
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78659238
64Vitamin digestion and absorption_Homo sapiens_hsa049770.76649552
65Arachidonic acid metabolism_Homo sapiens_hsa005900.75461797
66Ribosome_Homo sapiens_hsa030100.74636742
67beta-Alanine metabolism_Homo sapiens_hsa004100.74274440
68Metabolic pathways_Homo sapiens_hsa011000.74029031
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69575432
70Ovarian steroidogenesis_Homo sapiens_hsa049130.68017582
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64802396
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.62278936
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61954089
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59542344
75p53 signaling pathway_Homo sapiens_hsa041150.58494722
76Glycerolipid metabolism_Homo sapiens_hsa005610.56156516
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55729954
78N-Glycan biosynthesis_Homo sapiens_hsa005100.55584736
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53283683
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.52958688
81mRNA surveillance pathway_Homo sapiens_hsa030150.52800801
82Steroid biosynthesis_Homo sapiens_hsa001000.49892288
83Folate biosynthesis_Homo sapiens_hsa007900.47420007
84Dorso-ventral axis formation_Homo sapiens_hsa043200.47379448
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46771128
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46090043
87Fat digestion and absorption_Homo sapiens_hsa049750.45156636
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.42237510
89Salivary secretion_Homo sapiens_hsa049700.40401229
90Circadian rhythm_Homo sapiens_hsa047100.39652713
91Primary immunodeficiency_Homo sapiens_hsa053400.39102505
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.38119726
93Pancreatic secretion_Homo sapiens_hsa049720.38027445
94Lysine degradation_Homo sapiens_hsa003100.36600246
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36275612
96Pyruvate metabolism_Homo sapiens_hsa006200.35828225
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35517798
98Serotonergic synapse_Homo sapiens_hsa047260.33551192
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32411235
100Morphine addiction_Homo sapiens_hsa050320.30681548

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