ZNF93

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.03143164
2chromatin remodeling at centromere (GO:0031055)5.02484673
3CENP-A containing nucleosome assembly (GO:0034080)4.85430198
4negative regulation of DNA-dependent DNA replication (GO:2000104)4.44204642
5histone exchange (GO:0043486)4.33070013
6protein localization to kinetochore (GO:0034501)4.12589498
7kinetochore organization (GO:0051383)4.09662055
8DNA replication checkpoint (GO:0000076)4.04970118
9regulation of mitotic spindle checkpoint (GO:1903504)4.02585027
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.02585027
11DNA replication-independent nucleosome assembly (GO:0006336)4.01688952
12DNA replication-independent nucleosome organization (GO:0034724)4.01688952
13mitotic metaphase plate congression (GO:0007080)3.96353396
14regulation of DNA endoreduplication (GO:0032875)3.94244796
15synapsis (GO:0007129)3.93046473
16mitotic sister chromatid cohesion (GO:0007064)3.82210118
17metaphase plate congression (GO:0051310)3.82023530
18kinetochore assembly (GO:0051382)3.81609434
19attachment of spindle microtubules to kinetochore (GO:0008608)3.79328122
20centriole replication (GO:0007099)3.74523526
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.71886204
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.71886204
23regulation of helicase activity (GO:0051095)3.70230791
24negative regulation of DNA recombination (GO:0045910)3.66163537
25regulation of centriole replication (GO:0046599)3.65961484
26replication fork processing (GO:0031297)3.63707055
27negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.61067365
28negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.61067365
29negative regulation of mitotic sister chromatid segregation (GO:0033048)3.61067365
30negative regulation of mitotic sister chromatid separation (GO:2000816)3.61067365
31negative regulation of sister chromatid segregation (GO:0033046)3.61067365
32regulation of meiosis I (GO:0060631)3.54247454
33negative regulation of chromosome segregation (GO:0051985)3.54070860
34spindle checkpoint (GO:0031577)3.48863716
35DNA replication-dependent nucleosome organization (GO:0034723)3.47006902
36DNA replication-dependent nucleosome assembly (GO:0006335)3.47006902
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.45313150
38mitotic spindle checkpoint (GO:0071174)3.43391838
39protein localization to chromosome, centromeric region (GO:0071459)3.37497084
40regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.37122850
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.37122850
42DNA catabolic process, exonucleolytic (GO:0000738)3.35592667
43DNA strand elongation involved in DNA replication (GO:0006271)3.33586367
44regulation of mitotic sister chromatid separation (GO:0010965)3.29726914
45regulation of mitotic sister chromatid segregation (GO:0033047)3.29726914
46regulation of sister chromatid segregation (GO:0033045)3.29726914
47establishment of integrated proviral latency (GO:0075713)3.24111914
48mitotic spindle assembly checkpoint (GO:0007094)3.24095870
49spindle assembly checkpoint (GO:0071173)3.19664734
50DNA ligation (GO:0006266)3.19643105
51sister chromatid segregation (GO:0000819)3.18087786
52postreplication repair (GO:0006301)3.17830602
53mitotic G2/M transition checkpoint (GO:0044818)3.17418635
54resolution of meiotic recombination intermediates (GO:0000712)3.16810617
55pre-miRNA processing (GO:0031054)3.16475400
56recombinational repair (GO:0000725)3.16016321
57DNA strand elongation (GO:0022616)3.15853958
58mitotic sister chromatid segregation (GO:0000070)3.15666264
59telomere maintenance via semi-conservative replication (GO:0032201)3.14761857
60double-strand break repair via homologous recombination (GO:0000724)3.12317906
61regulation of chromosome segregation (GO:0051983)3.12233800
62maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10956609
63non-recombinational repair (GO:0000726)3.10804030
64double-strand break repair via nonhomologous end joining (GO:0006303)3.10804030
65regulation of translation, ncRNA-mediated (GO:0045974)3.10500541
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10500541
67negative regulation of translation, ncRNA-mediated (GO:0040033)3.10500541
68histone H2A acetylation (GO:0043968)3.06923209
69mitotic recombination (GO:0006312)3.03540429
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00742474
71DNA strand renaturation (GO:0000733)3.00036757
72DNA damage response, detection of DNA damage (GO:0042769)2.98599835
73female gonad development (GO:0008585)2.93344414
74response to X-ray (GO:0010165)2.90099674
75negative regulation of mitosis (GO:0045839)2.88855517
76microtubule depolymerization (GO:0007019)2.88543737
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87876313
78protein neddylation (GO:0045116)2.86194314
79telomere maintenance via recombination (GO:0000722)2.85395993
80establishment of chromosome localization (GO:0051303)2.84952400
81protein K6-linked ubiquitination (GO:0085020)2.84286762
82meiotic chromosome segregation (GO:0045132)2.83217486
83somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82993817
84isotype switching (GO:0045190)2.82993817
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82993817
86regulation of centrosome cycle (GO:0046605)2.82627858
87protein localization to chromosome (GO:0034502)2.81503602
88sister chromatid cohesion (GO:0007062)2.81225202
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.80543560
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80075917
91ATP-dependent chromatin remodeling (GO:0043044)2.79180974
92purine nucleobase biosynthetic process (GO:0009113)2.76594922
93IMP biosynthetic process (GO:0006188)2.75607834
94reciprocal meiotic recombination (GO:0007131)2.74879729
95reciprocal DNA recombination (GO:0035825)2.74879729
96regulation of double-strand break repair via homologous recombination (GO:0010569)2.72990490
97DNA recombination (GO:0006310)2.71949173
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71715838
99negative regulation of nuclear division (GO:0051784)2.70780229
100translesion synthesis (GO:0019985)2.69654434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48292775
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.72559251
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.67466944
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65587614
5ZNF274_21170338_ChIP-Seq_K562_Hela3.14571686
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.03014761
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.02677603
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.73635577
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.63015920
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61471082
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54050113
12ELK1_19687146_ChIP-ChIP_HELA_Human2.27647770
13EWS_26573619_Chip-Seq_HEK293_Human2.27346899
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23231137
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21048065
16IGF1R_20145208_ChIP-Seq_DFB_Human2.20692006
17VDR_22108803_ChIP-Seq_LS180_Human2.17889161
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16183980
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14228779
20FUS_26573619_Chip-Seq_HEK293_Human2.04001803
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01438240
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97966050
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93212992
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.79816281
25P300_19829295_ChIP-Seq_ESCs_Human1.78083999
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73293541
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69341705
28SOX2_16153702_ChIP-ChIP_HESCs_Human1.67848407
29TAF15_26573619_Chip-Seq_HEK293_Human1.67316375
30VDR_23849224_ChIP-Seq_CD4+_Human1.65988866
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.65556642
32MYC_18940864_ChIP-ChIP_HL60_Human1.63845369
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63599993
34GBX2_23144817_ChIP-Seq_PC3_Human1.63100990
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60687332
36FOXP3_21729870_ChIP-Seq_TREG_Human1.57100953
37NANOG_16153702_ChIP-ChIP_HESCs_Human1.56704261
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.56487681
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56276366
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.53061037
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.52452954
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47784197
43AR_21909140_ChIP-Seq_LNCAP_Human1.47207079
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46984516
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45822390
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42122737
47IRF1_19129219_ChIP-ChIP_H3396_Human1.41547683
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39628165
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34409485
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31386720
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31256782
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31119114
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28515860
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28115138
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27639634
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27639634
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27639634
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.23131514
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22670295
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16528717
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15921022
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12834031
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12078758
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12005393
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10924800
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10221961
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09409483
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08392401
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08392401
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07163367
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05921216
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05634913
73EZH2_22144423_ChIP-Seq_EOC_Human1.05479488
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05272305
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04530805
76TTF2_22483619_ChIP-Seq_HELA_Human1.02810184
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.00745055
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00024666
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.99315063
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99306354
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99062530
82BCAT_22108803_ChIP-Seq_LS180_Human0.98610853
83ER_23166858_ChIP-Seq_MCF-7_Human0.97854023
84MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97795730
85E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96334486
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95725475
87GABP_19822575_ChIP-Seq_HepG2_Human0.95394938
88SMAD4_21799915_ChIP-Seq_A2780_Human0.95144931
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94925341
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94723542
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93370374
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92982056
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92751611
94DCP1A_22483619_ChIP-Seq_HELA_Human0.92459515
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91570657
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90980867
97CBP_20019798_ChIP-Seq_JUKART_Human0.90980867
98TP53_22573176_ChIP-Seq_HFKS_Human0.90944323
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90644365
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.89793158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.27582204
2MP0010094_abnormal_chromosome_stability3.71975729
3MP0008057_abnormal_DNA_replication3.56278708
4MP0008058_abnormal_DNA_repair3.55858040
5MP0003693_abnormal_embryo_hatching3.19656350
6MP0006292_abnormal_olfactory_placode3.11724190
7MP0003890_abnormal_embryonic-extraembry2.84686812
8MP0003718_maternal_effect2.72339235
9MP0003111_abnormal_nucleus_morphology2.58421767
10MP0004957_abnormal_blastocyst_morpholog2.46079081
11MP0002102_abnormal_ear_morphology2.42493974
12MP0003787_abnormal_imprinting2.33132390
13MP0003077_abnormal_cell_cycle2.19391468
14MP0001293_anophthalmia2.19309210
15MP0003941_abnormal_skin_development2.12469667
16MP0001188_hyperpigmentation2.09373841
17MP0003121_genomic_imprinting2.08375429
18MP0008932_abnormal_embryonic_tissue2.06756598
19MP0001529_abnormal_vocalization1.79395583
20MP0002254_reproductive_system_inflammat1.78388481
21MP0008789_abnormal_olfactory_epithelium1.78041929
22MP0003880_abnormal_central_pattern1.69113608
23MP0008007_abnormal_cellular_replicative1.68497553
24MP0004133_heterotaxia1.68453391
25MP0006072_abnormal_retinal_apoptosis1.67903711
26MP0003119_abnormal_digestive_system1.66299119
27MP0009697_abnormal_copulation1.66046660
28MP0003937_abnormal_limbs/digits/tail_de1.61396642
29MP0003136_yellow_coat_color1.61037071
30MP0002938_white_spotting1.50261158
31MP0002751_abnormal_autonomic_nervous1.49289319
32MP0005499_abnormal_olfactory_system1.46333625
33MP0005394_taste/olfaction_phenotype1.46333625
34MP0003567_abnormal_fetal_cardiomyocyte1.45471743
35MP0003122_maternal_imprinting1.38869067
36MP0002210_abnormal_sex_determination1.38789298
37MP0003786_premature_aging1.38019018
38MP0001929_abnormal_gametogenesis1.36572672
39MP0002233_abnormal_nose_morphology1.34175204
40MP0001286_abnormal_eye_development1.34156521
41MP0002736_abnormal_nociception_after1.24529816
42MP0006276_abnormal_autonomic_nervous1.24059677
43MP0000631_abnormal_neuroendocrine_gland1.21192557
44MP0001145_abnormal_male_reproductive1.19583177
45MP0000653_abnormal_sex_gland1.19418131
46MP0009672_abnormal_birth_weight1.18621788
47MP0000647_abnormal_sebaceous_gland1.17440932
48MP0008995_early_reproductive_senescence1.16904166
49MP0010030_abnormal_orbit_morphology1.16234315
50MP0000049_abnormal_middle_ear1.16169426
51MP0002084_abnormal_developmental_patter1.14540266
52MP0005253_abnormal_eye_physiology1.12979666
53MP0003123_paternal_imprinting1.11704101
54MP0009703_decreased_birth_body1.11352494
55MP0001485_abnormal_pinna_reflex1.10973052
56MP0000778_abnormal_nervous_system1.09381634
57MP0002234_abnormal_pharynx_morphology1.08799621
58MP0010307_abnormal_tumor_latency1.06914499
59MP0002085_abnormal_embryonic_tissue1.05598299
60MP0003195_calcinosis1.04833188
61MP0005551_abnormal_eye_electrophysiolog1.01091643
62MP0003698_abnormal_male_reproductive0.99214320
63MP0002697_abnormal_eye_size0.98879982
64MP0004197_abnormal_fetal_growth/weight/0.98512683
65MP0001119_abnormal_female_reproductive0.98428993
66MP0002653_abnormal_ependyma_morphology0.97844290
67MP0001730_embryonic_growth_arrest0.97625420
68MP0001672_abnormal_embryogenesis/_devel0.97254494
69MP0005380_embryogenesis_phenotype0.97254494
70MP0001177_atelectasis0.96515093
71MP0001697_abnormal_embryo_size0.96373282
72MP0005395_other_phenotype0.95487743
73MP0003861_abnormal_nervous_system0.94328972
74MP0001984_abnormal_olfaction0.94139282
75MP0003755_abnormal_palate_morphology0.90403561
76MP0006035_abnormal_mitochondrial_morpho0.90009018
77MP0000350_abnormal_cell_proliferation0.88777865
78MP0002111_abnormal_tail_morphology0.88394052
79MP0000372_irregular_coat_pigmentation0.88144533
80MP0005084_abnormal_gallbladder_morpholo0.86012227
81MP0000427_abnormal_hair_cycle0.85885039
82MP0000516_abnormal_urinary_system0.84383659
83MP0005367_renal/urinary_system_phenotyp0.84383659
84MP0005391_vision/eye_phenotype0.82914060
85MP0001968_abnormal_touch/_nociception0.82820351
86MP0000569_abnormal_digit_pigmentation0.80216516
87MP0004147_increased_porphyrin_level0.75760480
88MP0000383_abnormal_hair_follicle0.74547150
89MP0001486_abnormal_startle_reflex0.74432321
90MP0002088_abnormal_embryonic_growth/wei0.73580958
91MP0003984_embryonic_growth_retardation0.73024495
92MP0002163_abnormal_gland_morphology0.70289110
93MP0001324_abnormal_eye_pigmentation0.69467442
94MP0002161_abnormal_fertility/fecundity0.69298879
95MP0001299_abnormal_eye_distance/0.66665748
96MP0004215_abnormal_myocardial_fiber0.65956347
97MP0002080_prenatal_lethality0.65834054
98MP0003935_abnormal_craniofacial_develop0.65772905
99MP0002837_dystrophic_cardiac_calcinosis0.65420600
100MP0002160_abnormal_reproductive_system0.64191538

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.64082447
2Colon cancer (HP:0003003)4.16105714
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47071917
4Abnormality of chromosome stability (HP:0003220)3.37077256
5Chromsome breakage (HP:0040012)3.32393437
6Meckel diverticulum (HP:0002245)3.28973862
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.26640291
8Abnormality of the ileum (HP:0001549)3.13080043
9Hyperglycinemia (HP:0002154)3.12851123
10Volvulus (HP:0002580)3.07602236
11Abnormal lung lobation (HP:0002101)2.93883756
12Birth length less than 3rd percentile (HP:0003561)2.76381250
13Septo-optic dysplasia (HP:0100842)2.71706919
14Abnormality of the preputium (HP:0100587)2.68736127
15Duodenal stenosis (HP:0100867)2.64296714
16Small intestinal stenosis (HP:0012848)2.64296714
17Rhabdomyosarcoma (HP:0002859)2.59745893
18Methylmalonic acidemia (HP:0002912)2.59224837
19Abnormality of the duodenum (HP:0002246)2.59058699
20Intestinal atresia (HP:0011100)2.56992635
21Pancreatic cysts (HP:0001737)2.54171091
22Molar tooth sign on MRI (HP:0002419)2.50246134
23Abnormality of midbrain morphology (HP:0002418)2.50246134
24Pancreatic fibrosis (HP:0100732)2.47591769
25Ependymoma (HP:0002888)2.44200089
26Oligodactyly (hands) (HP:0001180)2.43381089
27Nephroblastoma (Wilms tumor) (HP:0002667)2.43048760
28Supernumerary spleens (HP:0009799)2.40878685
29Sloping forehead (HP:0000340)2.37739766
30Medulloblastoma (HP:0002885)2.36552623
31Cortical dysplasia (HP:0002539)2.36529535
32Embryonal renal neoplasm (HP:0011794)2.33634806
33True hermaphroditism (HP:0010459)2.26096486
34Abnormality of glycine metabolism (HP:0010895)2.23686365
35Abnormality of serine family amino acid metabolism (HP:0010894)2.23686365
36Bifid tongue (HP:0010297)2.17983002
37Neoplasm of the oral cavity (HP:0100649)2.17161209
38Triphalangeal thumb (HP:0001199)2.16172124
39Ectopic kidney (HP:0000086)2.16141297
40Absent radius (HP:0003974)2.13032830
41Clubbing of toes (HP:0100760)2.11790807
42Nephronophthisis (HP:0000090)2.10181298
43Chronic hepatic failure (HP:0100626)2.10005112
44Hyperglycinuria (HP:0003108)2.04045804
45Absent forearm bone (HP:0003953)2.03992549
46Aplasia involving forearm bones (HP:0009822)2.03992549
47Median cleft lip (HP:0000161)2.03803343
48Glioma (HP:0009733)2.03649130
49Progressive inability to walk (HP:0002505)2.03450029
50Small hand (HP:0200055)2.01775717
51Agnosia (HP:0010524)2.01042343
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.00589872
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00354357
54Preaxial hand polydactyly (HP:0001177)1.99909077
55Abnormality of serum amino acid levels (HP:0003112)1.97620831
56Dandy-Walker malformation (HP:0001305)1.96743428
57Neoplasm of the adrenal cortex (HP:0100641)1.96247475
58Methylmalonic aciduria (HP:0012120)1.92717705
59Abnormality of the carotid arteries (HP:0005344)1.91129342
60Aqueductal stenosis (HP:0002410)1.89415611
61Medial flaring of the eyebrow (HP:0010747)1.89290246
62Patellar aplasia (HP:0006443)1.88110981
63Anencephaly (HP:0002323)1.86020237
64Absent septum pellucidum (HP:0001331)1.84512687
65Carpal bone hypoplasia (HP:0001498)1.84431508
66Optic nerve hypoplasia (HP:0000609)1.84020949
67Abolished electroretinogram (ERG) (HP:0000550)1.83950895
68Genital tract atresia (HP:0001827)1.83864811
69Abdominal situs inversus (HP:0003363)1.83771289
70Abnormality of abdominal situs (HP:0011620)1.83771289
71Gonadotropin excess (HP:0000837)1.83758103
72Hypoplastic female external genitalia (HP:0012815)1.83375700
73Neoplasm of the colon (HP:0100273)1.82469634
74Horseshoe kidney (HP:0000085)1.80836187
75Stenosis of the external auditory canal (HP:0000402)1.79966930
76Vaginal atresia (HP:0000148)1.79616980
77Hypoplastic pelvis (HP:0008839)1.78978608
78Tubulointerstitial nephritis (HP:0001970)1.76014016
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.75640437
80Abnormality of the astrocytes (HP:0100707)1.74652585
81Astrocytoma (HP:0009592)1.74652585
82Myelodysplasia (HP:0002863)1.74424150
83Nephrogenic diabetes insipidus (HP:0009806)1.73457187
84Increased nuchal translucency (HP:0010880)1.73318206
85Impulsivity (HP:0100710)1.72773820
86Abnormality of the renal medulla (HP:0100957)1.72061666
87Aplasia/Hypoplasia of the patella (HP:0006498)1.71563713
88Gastrointestinal atresia (HP:0002589)1.71501354
89Abnormality of the septum pellucidum (HP:0007375)1.71404435
90Neoplasm of the adrenal gland (HP:0100631)1.71266334
91Oligodactyly (HP:0012165)1.71196869
92Neoplasm of striated muscle (HP:0009728)1.70096487
93Renal hypoplasia (HP:0000089)1.69404699
94Bilateral microphthalmos (HP:0007633)1.68421059
95Anophthalmia (HP:0000528)1.68283470
96Astigmatism (HP:0000483)1.67957658
97Sclerocornea (HP:0000647)1.67756745
98Inability to walk (HP:0002540)1.67606422
99Biliary tract neoplasm (HP:0100574)1.67242164
100Pendular nystagmus (HP:0012043)1.67226833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.70185022
2BUB13.26971572
3CDC73.08651463
4MKNK22.99578836
5ZAK2.82447010
6NUAK12.77327403
7WNK32.74604603
8PLK42.69479527
9TTK2.64775346
10BRSK22.58916055
11WEE12.53745177
12MKNK12.35170750
13NEK12.23074248
14PLK32.21405349
15TSSK62.14574476
16SRPK12.05966180
17ACVR1B2.02078126
18TNIK1.99190916
19BMPR1B1.94702017
20EIF2AK31.90505309
21FRK1.73488710
22VRK21.70409645
23PBK1.66963138
24PLK11.65077947
25STK161.64760765
26TAF11.63486753
27VRK11.51839225
28BCR1.45854347
29MST41.41783027
30PNCK1.36754100
31MAP4K21.33739622
32CASK1.33346799
33MAP3K41.27987172
34ATR1.21942780
35BRSK11.21846527
36DYRK31.15340479
37DYRK21.12502416
38CDK191.11974756
39ERBB41.06956346
40PLK21.06001787
41CHEK21.04065340
42NEK21.03641153
43EPHA41.02339130
44STK38L0.95259570
45CSNK1G10.91231812
46STK30.88881446
47INSRR0.88528528
48OXSR10.88115553
49ATM0.86889681
50GRK10.86782488
51EIF2AK20.82250784
52AURKB0.80176491
53BRD40.79422215
54MAPK130.78133408
55TGFBR10.76825295
56CSNK1G20.73692734
57CHEK10.73419166
58NLK0.68524074
59CSNK1G30.64370285
60PASK0.64096819
61ADRBK20.58967003
62ERBB30.58678118
63BCKDK0.57964499
64MAP2K70.56651082
65CDK30.55890279
66MELK0.55412976
67PRKCG0.54417878
68EIF2AK10.52586314
69TIE10.50951058
70STK390.50799758
71BRAF0.43878383
72CSNK1A1L0.43700455
73LATS10.43646171
74DYRK1A0.43642744
75TLK10.43557875
76CDK10.42825322
77AURKA0.42468853
78PRKCE0.41519755
79FGFR20.40546290
80NME10.40201567
81CDK70.39649862
82YES10.39335865
83PRKDC0.38944849
84PAK30.38769507
85FGFR10.38373765
86CSNK2A10.37359249
87CDK20.36981261
88CAMK1G0.36886163
89CSNK1E0.36781780
90PDK20.36340602
91RPS6KA40.36040268
92STK40.34077309
93TEC0.31725519
94PKN10.30969379
95MINK10.30300802
96CSNK2A20.29268327
97WNK40.28642615
98PINK10.28525731
99AKT30.28047419
100CSNK1D0.25655651

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.82735861
2Non-homologous end-joining_Homo sapiens_hsa034503.47207758
3Homologous recombination_Homo sapiens_hsa034403.34091255
4DNA replication_Homo sapiens_hsa030303.24529618
5Fanconi anemia pathway_Homo sapiens_hsa034603.17669756
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55561639
7Basal transcription factors_Homo sapiens_hsa030222.49226493
8RNA polymerase_Homo sapiens_hsa030202.45993315
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.38839571
10Proteasome_Homo sapiens_hsa030502.38677932
11Protein export_Homo sapiens_hsa030602.36206137
12Cell cycle_Homo sapiens_hsa041102.34023030
13Base excision repair_Homo sapiens_hsa034102.27800165
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24702857
15RNA degradation_Homo sapiens_hsa030182.19879007
16RNA transport_Homo sapiens_hsa030132.19779998
17Propanoate metabolism_Homo sapiens_hsa006402.05864048
18Steroid biosynthesis_Homo sapiens_hsa001002.05617933
19Spliceosome_Homo sapiens_hsa030401.89189277
20Nucleotide excision repair_Homo sapiens_hsa034201.79384010
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78476788
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65048968
23Selenocompound metabolism_Homo sapiens_hsa004501.61804706
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60174865
25One carbon pool by folate_Homo sapiens_hsa006701.58198704
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.58035957
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45857692
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45443307
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35261779
30Oocyte meiosis_Homo sapiens_hsa041141.31238735
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30558094
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27115037
33mRNA surveillance pathway_Homo sapiens_hsa030151.27072820
34p53 signaling pathway_Homo sapiens_hsa041151.24410761
35Phototransduction_Homo sapiens_hsa047441.23652153
36Pyrimidine metabolism_Homo sapiens_hsa002401.23369936
37Fatty acid elongation_Homo sapiens_hsa000621.21920806
38Butanoate metabolism_Homo sapiens_hsa006501.21683670
39Purine metabolism_Homo sapiens_hsa002301.10993608
40Oxidative phosphorylation_Homo sapiens_hsa001901.10387939
41Parkinsons disease_Homo sapiens_hsa050121.09143805
42Huntingtons disease_Homo sapiens_hsa050161.02104851
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98495437
44Nicotine addiction_Homo sapiens_hsa050330.96382750
45Pyruvate metabolism_Homo sapiens_hsa006200.90156749
46Caffeine metabolism_Homo sapiens_hsa002320.87315048
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78953757
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77141774
49Vitamin B6 metabolism_Homo sapiens_hsa007500.72948616
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.69964919
51Fatty acid metabolism_Homo sapiens_hsa012120.69932945
52TGF-beta signaling pathway_Homo sapiens_hsa043500.69653771
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67525853
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67296095
55Basal cell carcinoma_Homo sapiens_hsa052170.64640569
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64236413
57Tryptophan metabolism_Homo sapiens_hsa003800.64155823
58Regulation of autophagy_Homo sapiens_hsa041400.63612560
59Vitamin digestion and absorption_Homo sapiens_hsa049770.63463685
60Ribosome_Homo sapiens_hsa030100.63297081
61Hippo signaling pathway_Homo sapiens_hsa043900.59983047
62Glutathione metabolism_Homo sapiens_hsa004800.59478524
63Metabolic pathways_Homo sapiens_hsa011000.58002842
64Hedgehog signaling pathway_Homo sapiens_hsa043400.57268974
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56090727
66Wnt signaling pathway_Homo sapiens_hsa043100.55143107
67Peroxisome_Homo sapiens_hsa041460.54419102
68Ether lipid metabolism_Homo sapiens_hsa005650.53453320
69Nitrogen metabolism_Homo sapiens_hsa009100.52594866
70Taste transduction_Homo sapiens_hsa047420.52184105
71beta-Alanine metabolism_Homo sapiens_hsa004100.52168314
72Linoleic acid metabolism_Homo sapiens_hsa005910.51973150
73Lysine degradation_Homo sapiens_hsa003100.51109048
74Fatty acid degradation_Homo sapiens_hsa000710.49951304
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48475249
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44902938
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44783045
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.44567418
79Retinol metabolism_Homo sapiens_hsa008300.43078860
80Olfactory transduction_Homo sapiens_hsa047400.41325638
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41137623
82Alzheimers disease_Homo sapiens_hsa050100.39181998
83Folate biosynthesis_Homo sapiens_hsa007900.39033614
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38097092
85Carbon metabolism_Homo sapiens_hsa012000.35129739
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30840636
87Biosynthesis of amino acids_Homo sapiens_hsa012300.30729791
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29959812
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29228254
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28787245
91Alcoholism_Homo sapiens_hsa050340.27886450
92Fat digestion and absorption_Homo sapiens_hsa049750.26474797
93Tight junction_Homo sapiens_hsa045300.25644797
94Systemic lupus erythematosus_Homo sapiens_hsa053220.23228207
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21317248
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20250089
97Arginine and proline metabolism_Homo sapiens_hsa003300.16347022
98Colorectal cancer_Homo sapiens_hsa052100.16032054
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15581177
100Cardiac muscle contraction_Homo sapiens_hsa042600.15319214

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