ZNF92

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.87177993
2chromatin remodeling at centromere (GO:0031055)4.54008033
3CENP-A containing nucleosome assembly (GO:0034080)4.40793106
4attachment of spindle microtubules to kinetochore (GO:0008608)3.99347358
5negative regulation of DNA-dependent DNA replication (GO:2000104)3.97125165
6kinetochore organization (GO:0051383)3.95069241
7histone exchange (GO:0043486)3.79618725
8sister chromatid segregation (GO:0000819)3.74751266
9nuclear pore complex assembly (GO:0051292)3.74099081
10negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.68473982
11negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.68473982
12negative regulation of mitotic sister chromatid segregation (GO:0033048)3.68473982
13negative regulation of mitotic sister chromatid separation (GO:2000816)3.68473982
14negative regulation of sister chromatid segregation (GO:0033046)3.68473982
15regulation of meiosis I (GO:0060631)3.68267006
16mitotic sister chromatid segregation (GO:0000070)3.67252409
17regulation of helicase activity (GO:0051095)3.66810194
18DNA replication-independent nucleosome organization (GO:0034724)3.66737970
19DNA replication-independent nucleosome assembly (GO:0006336)3.66737970
20negative regulation of chromosome segregation (GO:0051985)3.63957423
21mitotic sister chromatid cohesion (GO:0007064)3.62529196
22regulation of DNA endoreduplication (GO:0032875)3.61196333
23nuclear pore organization (GO:0006999)3.60782845
24replication fork processing (GO:0031297)3.60708094
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.59308036
26regulation of mitotic spindle checkpoint (GO:1903504)3.59308036
27DNA replication checkpoint (GO:0000076)3.57049771
28mitotic metaphase plate congression (GO:0007080)3.55132067
29resolution of meiotic recombination intermediates (GO:0000712)3.53920768
30regulation of centriole replication (GO:0046599)3.53497331
31negative regulation of DNA recombination (GO:0045910)3.53418999
32pyrimidine nucleobase catabolic process (GO:0006208)3.52559991
33mitotic spindle checkpoint (GO:0071174)3.51258772
34regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48720466
35regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48720466
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.48489946
37somatic diversification of immune receptors via somatic mutation (GO:0002566)3.48489946
38spindle checkpoint (GO:0031577)3.45494555
39regulation of sister chromatid segregation (GO:0033045)3.44922733
40regulation of mitotic sister chromatid separation (GO:0010965)3.44922733
41regulation of mitotic sister chromatid segregation (GO:0033047)3.44922733
42protein localization to kinetochore (GO:0034501)3.44741751
43mitotic spindle assembly checkpoint (GO:0007094)3.42801731
44meiotic chromosome segregation (GO:0045132)3.40459314
45spindle assembly checkpoint (GO:0071173)3.39538368
46synapsis (GO:0007129)3.38194816
47metaphase plate congression (GO:0051310)3.35276860
48transcription from mitochondrial promoter (GO:0006390)3.28283073
49microtubule depolymerization (GO:0007019)3.27089844
50kinetochore assembly (GO:0051382)3.26275867
51DNA synthesis involved in DNA repair (GO:0000731)3.22811065
52histone H2A acetylation (GO:0043968)3.20530571
53DNA catabolic process, exonucleolytic (GO:0000738)3.18094074
54DNA damage response, detection of DNA damage (GO:0042769)3.15082880
55regulation of chromosome segregation (GO:0051983)3.14837638
56DNA ligation (GO:0006266)3.13937895
57protein localization to chromosome, centromeric region (GO:0071459)3.13343007
58regulation of sister chromatid cohesion (GO:0007063)3.11804205
59maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10026769
60DNA replication-dependent nucleosome organization (GO:0034723)3.09502938
61DNA replication-dependent nucleosome assembly (GO:0006335)3.09502938
62reciprocal meiotic recombination (GO:0007131)3.07828584
63reciprocal DNA recombination (GO:0035825)3.07828584
64neural tube formation (GO:0001841)3.07751236
65histone mRNA metabolic process (GO:0008334)3.07517338
66regulation of nuclear cell cycle DNA replication (GO:0033262)3.06992207
67centriole replication (GO:0007099)3.05116712
68DNA strand elongation involved in DNA replication (GO:0006271)3.01155380
69DNA topological change (GO:0006265)2.97515361
70establishment of integrated proviral latency (GO:0075713)2.96853827
71pre-miRNA processing (GO:0031054)2.93777956
72microtubule anchoring (GO:0034453)2.93239193
73mitotic recombination (GO:0006312)2.92732518
74non-recombinational repair (GO:0000726)2.92711357
75double-strand break repair via nonhomologous end joining (GO:0006303)2.92711357
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91955332
77mitotic nuclear envelope disassembly (GO:0007077)2.91453181
78microtubule polymerization or depolymerization (GO:0031109)2.90214295
79sister chromatid cohesion (GO:0007062)2.89980968
80postreplication repair (GO:0006301)2.89051462
81telomere maintenance via semi-conservative replication (GO:0032201)2.88539716
82ATP-dependent chromatin remodeling (GO:0043044)2.86385664
83purine nucleobase biosynthetic process (GO:0009113)2.84920570
84DNA strand elongation (GO:0022616)2.84509040
85protein localization to chromosome (GO:0034502)2.81054186
86mitotic G2/M transition checkpoint (GO:0044818)2.77615235
87negative regulation of mitosis (GO:0045839)2.77526095
88pore complex assembly (GO:0046931)2.76708221
89chromosome organization involved in meiosis (GO:0070192)2.76195482
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76024219
91nuclear envelope disassembly (GO:0051081)2.75743386
92membrane disassembly (GO:0030397)2.75743386
93telomere maintenance via recombination (GO:0000722)2.73959466
94male meiosis I (GO:0007141)2.67987371
95meiotic cell cycle process (GO:1903046)2.67429044
96recombinational repair (GO:0000725)2.67280732
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67077311
98proteasome assembly (GO:0043248)2.66509326
99chromosome segregation (GO:0007059)2.65857882
100piRNA metabolic process (GO:0034587)2.65551841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20167853
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95410066
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28076124
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.02328155
5ZNF274_21170338_ChIP-Seq_K562_Hela2.87032403
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.85832791
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83412528
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.75531010
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75259866
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.74604499
11IGF1R_20145208_ChIP-Seq_DFB_Human2.74540205
12ELK1_19687146_ChIP-ChIP_HELA_Human2.58234120
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42745836
14EWS_26573619_Chip-Seq_HEK293_Human2.36891145
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35265015
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30834244
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30280224
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28708077
19FUS_26573619_Chip-Seq_HEK293_Human2.24604440
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23895829
21TAF15_26573619_Chip-Seq_HEK293_Human2.18918757
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16122882
23VDR_23849224_ChIP-Seq_CD4+_Human2.14088126
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07132970
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.00592572
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97911042
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97490975
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87763686
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.85401218
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83787105
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.83128025
32FOXP3_21729870_ChIP-Seq_TREG_Human1.75517750
33IRF1_19129219_ChIP-ChIP_H3396_Human1.74058087
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.71264614
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66993776
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64224226
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60870475
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60097909
39MYC_18940864_ChIP-ChIP_HL60_Human1.58979823
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.57633163
41P300_19829295_ChIP-Seq_ESCs_Human1.52573039
42VDR_22108803_ChIP-Seq_LS180_Human1.49859041
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.49507767
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48126250
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44441901
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44209655
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.42352689
48AR_21909140_ChIP-Seq_LNCAP_Human1.41216139
49TTF2_22483619_ChIP-Seq_HELA_Human1.38135370
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33387548
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32645252
52* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30556090
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29152486
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.28974946
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28025064
56SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26344042
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25663686
58DCP1A_22483619_ChIP-Seq_HELA_Human1.25384334
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24429211
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23127795
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22397389
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21729759
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19242404
64GABP_19822575_ChIP-Seq_HepG2_Human1.16425753
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16127180
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16097507
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14845729
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12884806
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09694343
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08470690
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06763911
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04952819
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03459557
74* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01908208
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01491134
76RNF2_27304074_Chip-Seq_NSC_Mouse1.01293795
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00390228
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99882870
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99832496
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99496264
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99458034
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99124378
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99124378
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99124378
85MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98908064
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.97883967
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97775307
88GBX2_23144817_ChIP-Seq_PC3_Human0.96093267
89ER_23166858_ChIP-Seq_MCF-7_Human0.95025239
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94224262
91CBP_20019798_ChIP-Seq_JUKART_Human0.94224262
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92976392
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92330929
94XRN2_22483619_ChIP-Seq_HELA_Human0.91369126
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90891720
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90409595
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89733958
98TP53_22573176_ChIP-Seq_HFKS_Human0.89324004
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88004052
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87218300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.91855815
2MP0008877_abnormal_DNA_methylation3.88748578
3MP0010094_abnormal_chromosome_stability3.52249066
4MP0008058_abnormal_DNA_repair3.41025614
5MP0006292_abnormal_olfactory_placode3.31400942
6MP0003693_abnormal_embryo_hatching2.80067079
7MP0003111_abnormal_nucleus_morphology2.76374313
8MP0003890_abnormal_embryonic-extraembry2.72570546
9MP0003880_abnormal_central_pattern2.58398285
10MP0008789_abnormal_olfactory_epithelium2.38310096
11MP0003077_abnormal_cell_cycle2.36923384
12MP0004957_abnormal_blastocyst_morpholog2.31817331
13MP0003787_abnormal_imprinting2.26374216
14MP0008007_abnormal_cellular_replicative2.24100137
15MP0009697_abnormal_copulation2.16912704
16MP0005394_taste/olfaction_phenotype2.07497452
17MP0005499_abnormal_olfactory_system2.07497452
18MP0001529_abnormal_vocalization2.06979103
19MP0003121_genomic_imprinting2.03364699
20MP0008932_abnormal_embryonic_tissue1.90555349
21MP0003136_yellow_coat_color1.84285748
22MP0001293_anophthalmia1.81549467
23MP0003718_maternal_effect1.76234538
24MP0008995_early_reproductive_senescence1.75016792
25MP0001188_hyperpigmentation1.68350753
26MP0003221_abnormal_cardiomyocyte_apopto1.67547773
27MP0002102_abnormal_ear_morphology1.59780672
28MP0001984_abnormal_olfaction1.56322015
29MP0002751_abnormal_autonomic_nervous1.55882269
30MP0003119_abnormal_digestive_system1.53566288
31MP0003567_abnormal_fetal_cardiomyocyte1.50802577
32MP0002210_abnormal_sex_determination1.50062150
33MP0002234_abnormal_pharynx_morphology1.48681076
34MP0003786_premature_aging1.48402920
35MP0001929_abnormal_gametogenesis1.47656943
36MP0006072_abnormal_retinal_apoptosis1.46775727
37MP0005367_renal/urinary_system_phenotyp1.41023507
38MP0000516_abnormal_urinary_system1.41023507
39MP0000631_abnormal_neuroendocrine_gland1.39167289
40MP0001145_abnormal_male_reproductive1.34497002
41MP0003937_abnormal_limbs/digits/tail_de1.34466343
42MP0004133_heterotaxia1.34325321
43MP0003122_maternal_imprinting1.32376689
44MP0000653_abnormal_sex_gland1.29274530
45MP0000778_abnormal_nervous_system1.28051542
46MP0001286_abnormal_eye_development1.25015268
47MP0005423_abnormal_somatic_nervous1.21599185
48MP0009703_decreased_birth_body1.20874556
49MP0001177_atelectasis1.18723137
50MP0005253_abnormal_eye_physiology1.18089025
51MP0004197_abnormal_fetal_growth/weight/1.17847185
52MP0002233_abnormal_nose_morphology1.17784027
53MP0000372_irregular_coat_pigmentation1.17504016
54MP0003698_abnormal_male_reproductive1.13696470
55MP0001730_embryonic_growth_arrest1.13112751
56MP0000049_abnormal_middle_ear1.11957884
57MP0002084_abnormal_developmental_patter1.09419232
58MP0006276_abnormal_autonomic_nervous1.07231290
59MP0001697_abnormal_embryo_size1.05688192
60MP0001485_abnormal_pinna_reflex1.04431494
61MP0002085_abnormal_embryonic_tissue1.01934308
62MP0003011_delayed_dark_adaptation1.01105023
63MP0001119_abnormal_female_reproductive1.00969769
64MP0005380_embryogenesis_phenotype1.00329865
65MP0001672_abnormal_embryogenesis/_devel1.00329865
66MP0002938_white_spotting1.00085548
67MP0005391_vision/eye_phenotype1.00068499
68MP0000350_abnormal_cell_proliferation0.99947728
69MP0000647_abnormal_sebaceous_gland0.99843712
70MP0009672_abnormal_birth_weight0.99233729
71MP0003861_abnormal_nervous_system0.97931605
72MP0002822_catalepsy0.97258865
73MP0002009_preneoplasia0.96795188
74MP0006035_abnormal_mitochondrial_morpho0.95996132
75MP0002160_abnormal_reproductive_system0.94140941
76MP0005551_abnormal_eye_electrophysiolog0.93047598
77MP0002638_abnormal_pupillary_reflex0.91498940
78MP0001764_abnormal_homeostasis0.90619114
79MP0003941_abnormal_skin_development0.90369986
80MP0002092_abnormal_eye_morphology0.86322678
81MP0004742_abnormal_vestibular_system0.84774688
82MP0010307_abnormal_tumor_latency0.84495991
83MP0002697_abnormal_eye_size0.82999429
84MP0002653_abnormal_ependyma_morphology0.81567256
85MP0002088_abnormal_embryonic_growth/wei0.80341887
86MP0003984_embryonic_growth_retardation0.80081398
87MP0002396_abnormal_hematopoietic_system0.75755668
88MP0000537_abnormal_urethra_morphology0.75521801
89MP0002111_abnormal_tail_morphology0.74633342
90MP0002080_prenatal_lethality0.74223450
91MP0003938_abnormal_ear_development0.74170172
92MP0005248_abnormal_Harderian_gland0.73987045
93MP0000313_abnormal_cell_death0.73845617
94MP0003755_abnormal_palate_morphology0.73773181
95MP0002161_abnormal_fertility/fecundity0.71619132
96MP0005389_reproductive_system_phenotype0.69879495
97MP0005084_abnormal_gallbladder_morpholo0.67906732
98MP0005645_abnormal_hypothalamus_physiol0.66003821
99MP0001324_abnormal_eye_pigmentation0.65624041
100MP0003315_abnormal_perineum_morphology0.65346119

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.85264277
2Abnormality of the labia minora (HP:0012880)3.71306908
3Colon cancer (HP:0003003)3.58593973
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.38281429
5Chromsome breakage (HP:0040012)3.29437295
6Nephroblastoma (Wilms tumor) (HP:0002667)3.11119501
7Abnormality of chromosome stability (HP:0003220)3.10736033
8Abnormal lung lobation (HP:0002101)3.08552031
9Embryonal renal neoplasm (HP:0011794)2.95840543
10Cortical dysplasia (HP:0002539)2.80958592
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.79329969
12Meckel diverticulum (HP:0002245)2.78179903
13Short tibia (HP:0005736)2.72984003
14Abnormality of the ileum (HP:0001549)2.65695948
15Supernumerary spleens (HP:0009799)2.63759595
16Aplasia/Hypoplasia of the tibia (HP:0005772)2.60164991
17Medulloblastoma (HP:0002885)2.59175197
18Septo-optic dysplasia (HP:0100842)2.40683296
19Hepatoblastoma (HP:0002884)2.38675206
20Duodenal stenosis (HP:0100867)2.36650763
21Small intestinal stenosis (HP:0012848)2.36650763
22Abnormality of the preputium (HP:0100587)2.36176578
23Sloping forehead (HP:0000340)2.34314564
24Oligodactyly (hands) (HP:0001180)2.30865551
25True hermaphroditism (HP:0010459)2.30634259
26Ependymoma (HP:0002888)2.30372653
27Birth length less than 3rd percentile (HP:0003561)2.24144392
28Abnormality of the duodenum (HP:0002246)2.23814581
29Congenital primary aphakia (HP:0007707)2.22204204
30Medial flaring of the eyebrow (HP:0010747)2.21204982
31Nephronophthisis (HP:0000090)2.18701438
32Gonadotropin excess (HP:0000837)2.18106126
33Genital tract atresia (HP:0001827)2.15941009
34Pancreatic fibrosis (HP:0100732)2.15471258
35Stenosis of the external auditory canal (HP:0000402)2.14965868
36Gait imbalance (HP:0002141)2.14073896
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.11789958
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.11005795
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11005795
40Nephrogenic diabetes insipidus (HP:0009806)2.09462570
41Molar tooth sign on MRI (HP:0002419)2.07840780
42Abnormality of midbrain morphology (HP:0002418)2.07840780
43Carpal bone hypoplasia (HP:0001498)2.07092700
44Pancreatic cysts (HP:0001737)2.06281620
45Intestinal atresia (HP:0011100)2.04693343
46Triphalangeal thumb (HP:0001199)2.03905772
47Median cleft lip (HP:0000161)2.03496357
48Glioma (HP:0009733)2.01908475
49Embryonal neoplasm (HP:0002898)2.00411086
50Postaxial foot polydactyly (HP:0001830)2.00003011
51Vaginal atresia (HP:0000148)1.98844819
52Papillary thyroid carcinoma (HP:0002895)1.96586973
53Rhabdomyosarcoma (HP:0002859)1.94498963
54Amyotrophic lateral sclerosis (HP:0007354)1.92239251
55Abnormal hair whorl (HP:0010721)1.92114919
56Tubulointerstitial nephritis (HP:0001970)1.91265152
57Drooling (HP:0002307)1.90400748
58Ectopic kidney (HP:0000086)1.89047527
59Neoplasm of the adrenal cortex (HP:0100641)1.86088003
60Neoplasm of the oral cavity (HP:0100649)1.85655954
61Hyperglycinemia (HP:0002154)1.85168280
62Myelodysplasia (HP:0002863)1.83927670
63Shoulder girdle muscle weakness (HP:0003547)1.83854397
64Astrocytoma (HP:0009592)1.83707552
65Abnormality of the astrocytes (HP:0100707)1.83707552
66Preaxial hand polydactyly (HP:0001177)1.83334542
67Optic nerve hypoplasia (HP:0000609)1.82825760
68Abnormality of the metopic suture (HP:0005556)1.82498497
69Impaired vibration sensation in the lower limbs (HP:0002166)1.81711376
70Progressive inability to walk (HP:0002505)1.81398000
71Broad foot (HP:0001769)1.81251922
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81200842
73Anencephaly (HP:0002323)1.80680196
74Abnormality of the septum pellucidum (HP:0007375)1.80207364
75Abnormality of the carotid arteries (HP:0005344)1.79165020
76Oligodactyly (HP:0012165)1.78244938
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77760524
78Absent septum pellucidum (HP:0001331)1.77336759
79Breast carcinoma (HP:0003002)1.77022875
80Neoplasm of the adrenal gland (HP:0100631)1.75435363
81Postaxial hand polydactyly (HP:0001162)1.75276635
82Increased nuchal translucency (HP:0010880)1.75210644
83Dandy-Walker malformation (HP:0001305)1.75123453
84Abnormality of the renal medulla (HP:0100957)1.74831477
85Neoplasm of the colon (HP:0100273)1.72764177
86Poor coordination (HP:0002370)1.72379676
87Clubbing of toes (HP:0100760)1.72326599
88Excessive salivation (HP:0003781)1.71449730
89Chronic hepatic failure (HP:0100626)1.70130538
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.69733732
91Abnormal biliary tract physiology (HP:0012439)1.69542479
92Bile duct proliferation (HP:0001408)1.69542479
93Gastrointestinal atresia (HP:0002589)1.69362370
94Facial hemangioma (HP:0000329)1.67688443
95Absent radius (HP:0003974)1.63937039
96Horseshoe kidney (HP:0000085)1.63382384
97Ovarian neoplasm (HP:0100615)1.62483083
98Methylmalonic acidemia (HP:0002912)1.61146680
99Abnormality of the antihelix (HP:0009738)1.61101907
100Aplasia involving forearm bones (HP:0009822)1.60534763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK193.59450566
2CDC72.86189958
3PLK42.77935580
4BUB12.74461506
5TRIM282.74007519
6SRPK12.64253827
7WNK32.36108291
8TTK2.35207118
9MAP3K42.30801358
10MKNK22.28684585
11NUAK12.26275215
12ZAK2.17230952
13BRSK22.13790530
14BCR2.12930937
15MKNK12.11239841
16WEE12.09989963
17DYRK32.01306732
18MAP4K21.97408828
19TSSK61.95959584
20BRD41.93168091
21EIF2AK31.89219613
22PBK1.82318221
23NEK11.80477659
24PLK31.68058364
25ERBB31.59457834
26TNIK1.51301402
27RPS6KA41.47062931
28PLK11.42933269
29VRK11.42569666
30BMPR1B1.41703584
31PLK21.39079698
32CSNK1G11.37007397
33CASK1.35643951
34CSNK1G21.30334319
35CSNK1G31.25986995
36ATR1.25510522
37DYRK21.19508485
38MAP2K71.14462504
39CSNK1A1L1.14403205
40STK161.13203264
41ACVR1B1.12314013
42EIF2AK11.11791171
43MST41.08787667
44MAP3K101.08490044
45PNCK1.06654861
46CDK31.04989629
47TAF10.99180405
48CCNB10.96924068
49NEK20.90955975
50CHEK20.90219373
51NLK0.90189621
52ERBB40.87347906
53ATM0.85883095
54STK38L0.84620671
55FRK0.84324061
56VRK20.83992901
57AURKB0.82056271
58MAPK130.77143112
59EPHA40.76527073
60STK30.73864547
61CHEK10.72311102
62AKT30.71289489
63PASK0.70383840
64BRSK10.69403310
65CDK60.69386799
66EIF2AK20.69009007
67YES10.66736704
68SIK30.66630522
69PINK10.56192950
70ADRBK20.55326465
71CLK10.55035804
72TEC0.51083128
73DYRK1A0.49915336
74PRKCE0.48378041
75MARK10.48174975
76LATS10.47603503
77CDK10.47498511
78CDK20.46464489
79EPHA30.43902820
80OXSR10.43413564
81STK390.42252422
82STK240.42012947
83GRK10.41222122
84SGK20.41103961
85MINK10.41097961
86DYRK1B0.38610071
87SCYL20.38160127
88CSNK2A10.38150292
89RPS6KA50.38104011
90BCKDK0.37608722
91CDK70.37460617
92FGFR10.33937556
93UHMK10.33914200
94CSNK1E0.33855520
95CSNK1A10.32717737
96CSNK1D0.31845892
97PRKDC0.31566958
98RAF10.31285893
99CSNK2A20.30739702
100CDK90.29105860

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.92162266
2DNA replication_Homo sapiens_hsa030303.23241906
3Homologous recombination_Homo sapiens_hsa034403.03479655
4Fanconi anemia pathway_Homo sapiens_hsa034602.99335040
5Non-homologous end-joining_Homo sapiens_hsa034502.94438623
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82672082
7Steroid biosynthesis_Homo sapiens_hsa001002.80814347
8Basal transcription factors_Homo sapiens_hsa030222.79740092
9Protein export_Homo sapiens_hsa030602.69559948
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.67670324
11RNA transport_Homo sapiens_hsa030132.67428434
12Cell cycle_Homo sapiens_hsa041102.61342686
13Spliceosome_Homo sapiens_hsa030402.51123127
14RNA degradation_Homo sapiens_hsa030182.37231008
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32316755
16Base excision repair_Homo sapiens_hsa034102.29217246
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.29194309
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25506175
19RNA polymerase_Homo sapiens_hsa030202.17987361
20Proteasome_Homo sapiens_hsa030502.17584869
21Nucleotide excision repair_Homo sapiens_hsa034202.09384218
22Propanoate metabolism_Homo sapiens_hsa006401.93948371
23mRNA surveillance pathway_Homo sapiens_hsa030151.92114587
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49760556
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.47991468
26p53 signaling pathway_Homo sapiens_hsa041151.47167467
27Oocyte meiosis_Homo sapiens_hsa041141.42710281
28One carbon pool by folate_Homo sapiens_hsa006701.41549167
29Pyrimidine metabolism_Homo sapiens_hsa002401.33023149
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30056426
31Selenocompound metabolism_Homo sapiens_hsa004501.24936337
32Phototransduction_Homo sapiens_hsa047441.18825502
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01279544
34Fatty acid elongation_Homo sapiens_hsa000621.00865554
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97864713
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94492993
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92982030
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92494139
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92420327
40Purine metabolism_Homo sapiens_hsa002300.92347736
41Alcoholism_Homo sapiens_hsa050340.90178694
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89151641
43Butanoate metabolism_Homo sapiens_hsa006500.85580643
44Nicotine addiction_Homo sapiens_hsa050330.84306366
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82655324
46Taste transduction_Homo sapiens_hsa047420.82278725
47Ribosome_Homo sapiens_hsa030100.80437156
48Parkinsons disease_Homo sapiens_hsa050120.77730965
49Systemic lupus erythematosus_Homo sapiens_hsa053220.75182903
50Huntingtons disease_Homo sapiens_hsa050160.75093636
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74821467
52Pyruvate metabolism_Homo sapiens_hsa006200.73247790
53TGF-beta signaling pathway_Homo sapiens_hsa043500.65531933
54Circadian rhythm_Homo sapiens_hsa047100.63843609
55Basal cell carcinoma_Homo sapiens_hsa052170.63044249
56Colorectal cancer_Homo sapiens_hsa052100.61298187
57Regulation of autophagy_Homo sapiens_hsa041400.57679308
58Vitamin B6 metabolism_Homo sapiens_hsa007500.57185866
59Hedgehog signaling pathway_Homo sapiens_hsa043400.57061324
60Wnt signaling pathway_Homo sapiens_hsa043100.55300031
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55100957
62Oxidative phosphorylation_Homo sapiens_hsa001900.55050136
63Olfactory transduction_Homo sapiens_hsa047400.53869526
64Lysine degradation_Homo sapiens_hsa003100.52781965
65Peroxisome_Homo sapiens_hsa041460.49285843
66Hippo signaling pathway_Homo sapiens_hsa043900.47389096
67Biosynthesis of amino acids_Homo sapiens_hsa012300.47059311
68beta-Alanine metabolism_Homo sapiens_hsa004100.45719242
69Viral carcinogenesis_Homo sapiens_hsa052030.44824070
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43676704
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39816805
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39783355
73Epstein-Barr virus infection_Homo sapiens_hsa051690.39703493
74Fatty acid metabolism_Homo sapiens_hsa012120.39152101
75Metabolic pathways_Homo sapiens_hsa011000.36220122
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35516813
77Primary immunodeficiency_Homo sapiens_hsa053400.33179502
78Carbon metabolism_Homo sapiens_hsa012000.32152831
79Nitrogen metabolism_Homo sapiens_hsa009100.30779274
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29155804
81N-Glycan biosynthesis_Homo sapiens_hsa005100.24989856
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24855217
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.24628197
84Retinol metabolism_Homo sapiens_hsa008300.23999969
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.23802509
86Ether lipid metabolism_Homo sapiens_hsa005650.23681875
87Tryptophan metabolism_Homo sapiens_hsa003800.23599240
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22921600
89MicroRNAs in cancer_Homo sapiens_hsa052060.21714532
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19891680
91Vitamin digestion and absorption_Homo sapiens_hsa049770.19679178
92Glutathione metabolism_Homo sapiens_hsa004800.19166924
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18934643
94Linoleic acid metabolism_Homo sapiens_hsa005910.17331353
95GABAergic synapse_Homo sapiens_hsa047270.17130220
96Serotonergic synapse_Homo sapiens_hsa047260.12359782
97Thyroid cancer_Homo sapiens_hsa052160.12098213
98Folate biosynthesis_Homo sapiens_hsa007900.11159035
99Long-term depression_Homo sapiens_hsa047300.11121731
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10881227

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