ZNF865

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.10422824
2negative regulation of cell killing (GO:0031342)3.69396990
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69396990
4response to peptidoglycan (GO:0032494)3.58744353
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50854945
6positive regulation by organism of defense response of other organism involved in symbiotic interact3.50854945
7modulation by symbiont of host immune response (GO:0052553)3.50854945
8positive regulation by symbiont of host defense response (GO:0052509)3.50854945
9modulation by symbiont of host defense response (GO:0052031)3.50854945
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50854945
11mannose metabolic process (GO:0006013)3.47923206
12apoptotic process involved in morphogenesis (GO:0060561)3.34859841
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34671825
14positive regulation of histone deacetylation (GO:0031065)3.26641340
15response to muramyl dipeptide (GO:0032495)3.18569600
16positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17949783
17antigen processing and presentation of endogenous antigen (GO:0019883)3.15330260
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13867890
19protein localization to endosome (GO:0036010)3.13182518
20negative regulation of cell size (GO:0045792)3.10411250
21positive regulation of gamma-delta T cell activation (GO:0046645)3.09945987
22germinal center formation (GO:0002467)3.06310338
23regulation of early endosome to late endosome transport (GO:2000641)3.05396508
24positive thymic T cell selection (GO:0045059)3.03986042
25response to laminar fluid shear stress (GO:0034616)3.03826502
263-UTR-mediated mRNA stabilization (GO:0070935)3.02280931
27thymic T cell selection (GO:0045061)2.98456607
28detection of bacterium (GO:0016045)2.97703293
29macrophage activation involved in immune response (GO:0002281)2.94502057
30modulation by symbiont of host cellular process (GO:0044068)2.93330834
31cell-substrate adherens junction assembly (GO:0007045)2.92479556
32focal adhesion assembly (GO:0048041)2.92479556
33adherens junction assembly (GO:0034333)2.92363362
34detection of other organism (GO:0098543)2.92033419
35positive regulation of Cdc42 GTPase activity (GO:0043089)2.91140141
36NIK/NF-kappaB signaling (GO:0038061)2.89324033
37stress fiber assembly (GO:0043149)2.88589780
38modulation by virus of host process (GO:0019054)2.84126755
39activation of Rac GTPase activity (GO:0032863)2.84087731
40leukocyte aggregation (GO:0070486)2.83858884
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80411214
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80078437
43regulation of T-helper 2 cell differentiation (GO:0045628)2.79434865
44intracellular estrogen receptor signaling pathway (GO:0030520)2.73639618
45regulation of extracellular matrix disassembly (GO:0010715)2.73353393
46signal complex assembly (GO:0007172)2.72617263
47barbed-end actin filament capping (GO:0051016)2.72263957
48positive regulation of myotube differentiation (GO:0010831)2.72012967
49regulation of leukocyte degranulation (GO:0043300)2.70663091
50negative regulation of necroptotic process (GO:0060546)2.69472591
51regulation of necroptotic process (GO:0060544)2.67571783
52positive regulation of protein deacetylation (GO:0090312)2.62867515
53regulation of ARF GTPase activity (GO:0032312)2.60197589
54neutrophil activation involved in immune response (GO:0002283)2.58343739
55negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57706398
56regulation of gamma-delta T cell activation (GO:0046643)2.57423449
57positive regulation of protein dephosphorylation (GO:0035307)2.55774452
58regulation of interferon-beta biosynthetic process (GO:0045357)2.55662460
59activation of MAPKKK activity (GO:0000185)2.53298505
60negative regulation of myotube differentiation (GO:0010832)2.53035195
61regulation of NFAT protein import into nucleus (GO:0051532)2.52508260
62negative regulation of toll-like receptor signaling pathway (GO:0034122)2.52393804
63positive regulation of receptor recycling (GO:0001921)2.52322283
64lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51223710
65regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49920207
66detection of external biotic stimulus (GO:0098581)2.48396430
67maternal placenta development (GO:0001893)2.48115175
68regulation of glucose import in response to insulin stimulus (GO:2001273)2.47272081
69positive regulation of blood vessel endothelial cell migration (GO:0043536)2.46954870
70regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46890820
71activation of JUN kinase activity (GO:0007257)2.46882528
72regulation of mast cell degranulation (GO:0043304)2.46703917
73atrioventricular valve morphogenesis (GO:0003181)2.45193398
74regulation of chromatin binding (GO:0035561)2.45160002
75T cell selection (GO:0045058)2.44655719
76response to host (GO:0075136)2.43795582
77response to host defenses (GO:0052200)2.43795582
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.43795582
79epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43265575
80embryonic process involved in female pregnancy (GO:0060136)2.42321205
81negative regulation of viral release from host cell (GO:1902187)2.42197733
82negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.41682644
83semaphorin-plexin signaling pathway (GO:0071526)2.41126216
84cellular response to virus (GO:0098586)2.40647195
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38177069
86regulation of gamma-delta T cell differentiation (GO:0045586)2.37634552
87cell-substrate junction assembly (GO:0007044)2.36636504
88negative regulation of phagocytosis (GO:0050765)2.35080986
89regulation of necrotic cell death (GO:0010939)2.34001393
90planar cell polarity pathway involved in neural tube closure (GO:0090179)2.33223958
91positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32206086
92pentose-phosphate shunt (GO:0006098)2.29660142
93cell-cell junction maintenance (GO:0045217)2.29230216
94pinocytosis (GO:0006907)2.28659606
95vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27362155
96negative regulation of granulocyte differentiation (GO:0030853)2.27256801
97negative regulation of skeletal muscle tissue development (GO:0048642)2.26978932
98response to host immune response (GO:0052572)2.26904565
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.26904565
100modulation by virus of host morphology or physiology (GO:0019048)2.25665084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.24056824
2MYC_22102868_ChIP-Seq_BL_Human3.02152149
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.99010646
4LXR_22292898_ChIP-Seq_THP-1_Human2.96129199
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.83867342
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.67931979
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.57415110
8KDM2B_26808549_Chip-Seq_DND41_Human2.49606681
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46120111
10TCF7_22412390_ChIP-Seq_EML_Mouse2.45879142
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41561241
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39175119
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.35351363
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35113085
15RACK7_27058665_Chip-Seq_MCF-7_Human2.24413917
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09371062
17VDR_24763502_ChIP-Seq_THP-1_Human2.07515729
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00365818
19KDM2B_26808549_Chip-Seq_K562_Human1.92909593
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87873097
21MAF_26560356_Chip-Seq_TH1_Human1.84110569
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.72121469
23KDM2B_26808549_Chip-Seq_JURKAT_Human1.71703325
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70618934
25P68_20966046_ChIP-Seq_HELA_Human1.65101040
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64340898
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64243479
28UTX_26944678_Chip-Seq_JUKART_Human1.63908796
29MAF_26560356_Chip-Seq_TH2_Human1.60591115
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60065617
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.59807864
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57707240
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.57506477
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54060695
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.53895633
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49778660
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48909369
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46915977
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45728751
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.45372710
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44399274
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42402242
43SMC4_20622854_ChIP-Seq_HELA_Human1.40414427
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40192503
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.40032170
46CREB1_26743006_Chip-Seq_LNCaP_Human1.38993191
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38875430
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38331503
49ZNF263_19887448_ChIP-Seq_K562_Human1.35969837
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.35761736
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35698797
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34558679
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34153116
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34134045
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33913869
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32192811
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31915611
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.30126550
59NCOR1_26117541_ChIP-Seq_K562_Human1.29461615
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28730687
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27436502
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25383185
63SPI1_23127762_ChIP-Seq_K562_Human1.25317040
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.25258370
65BCOR_27268052_Chip-Seq_Bcells_Human1.23928076
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23611094
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20749579
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19259966
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.18870460
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18168304
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17941740
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17752637
73BCL6_27268052_Chip-Seq_Bcells_Human1.17660569
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16354834
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16035497
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12605985
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11949216
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.10939252
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10537413
80CTCF_27219007_Chip-Seq_Bcells_Human1.09275580
81SCL_19346495_ChIP-Seq_HPC-7_Human1.09208164
82ATF3_27146783_Chip-Seq_COLON_Human1.08833637
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05721345
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04446000
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02653173
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02153905
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02062263
88CLOCK_20551151_ChIP-Seq_293T_Human1.00845443
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00518369
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00470835
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00440142
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99994356
93CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99093715
94STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98819979
95TP53_22127205_ChIP-Seq_IMR90_Human0.98745281
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97051732
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97029748
98GATA1_19941826_ChIP-Seq_K562_Human0.96133804
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95879521
100SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95780757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.90364092
2MP0005451_abnormal_body_composition3.35448977
3MP0003436_decreased_susceptibility_to3.07843353
4MP0003303_peritoneal_inflammation2.97986730
5MP0005058_abnormal_lysosome_morphology2.74514345
6MP0005076_abnormal_cell_differentiation2.54567859
7MP0004510_myositis2.36643190
8MP0003300_gastrointestinal_ulcer2.32057967
9MP0009278_abnormal_bone_marrow2.31324797
10MP0000751_myopathy2.27209600
11MP0003172_abnormal_lysosome_physiology2.20563074
12MP0008260_abnormal_autophagy2.09745190
13MP0004858_abnormal_nervous_system2.02519513
14MP0001849_ear_inflammation1.90641156
15MP0009840_abnormal_foam_cell1.87994628
16MP0003191_abnormal_cellular_cholesterol1.87860331
17MP0004185_abnormal_adipocyte_glucose1.80665099
18MP0000685_abnormal_immune_system1.74937990
19MP0003453_abnormal_keratinocyte_physiol1.74925100
20MP0004947_skin_inflammation1.73871530
21MP0002419_abnormal_innate_immunity1.71081069
22MP0003279_aneurysm1.64896087
23MP0003763_abnormal_thymus_physiology1.62950600
24MP0005025_abnormal_response_to1.61508107
25MP0001790_abnormal_immune_system1.57957017
26MP0005387_immune_system_phenotype1.57957017
27MP0003091_abnormal_cell_migration1.56368124
28MP0003724_increased_susceptibility_to1.56045876
29MP0005000_abnormal_immune_tolerance1.55577893
30MP0003566_abnormal_cell_adhesion1.55280042
31MP0005666_abnormal_adipose_tissue1.54142201
32MP0002249_abnormal_larynx_morphology1.51179111
33MP0000858_altered_metastatic_potential1.46958744
34MP0005409_darkened_coat_color1.46938873
35MP0000678_abnormal_parathyroid_gland1.46868993
36MP0001533_abnormal_skeleton_physiology1.46694834
37MP0000747_muscle_weakness1.45899855
38MP0000759_abnormal_skeletal_muscle1.45764596
39MP0002877_abnormal_melanocyte_morpholog1.45150318
40MP0009333_abnormal_splenocyte_physiolog1.44607755
41MP0004381_abnormal_hair_follicle1.42890149
42MP0000733_abnormal_muscle_development1.42016372
43MP0001835_abnormal_antigen_presentation1.41171251
44MP0002998_abnormal_bone_remodeling1.38126995
45MP0001800_abnormal_humoral_immune1.34279903
46MP0005375_adipose_tissue_phenotype1.32730685
47MP0002420_abnormal_adaptive_immunity1.30559211
48MP0001819_abnormal_immune_cell1.29620057
49MP0002723_abnormal_immune_serum1.29184603
50MP0003828_pulmonary_edema1.28484882
51MP0002452_abnormal_antigen_presenting1.26067914
52MP0008438_abnormal_cutaneous_collagen1.25885499
53MP0004087_abnormal_muscle_fiber1.25340130
54MP0000750_abnormal_muscle_regeneration1.25235175
55MP0001348_abnormal_lacrimal_gland1.24592420
56MP0001873_stomach_inflammation1.22523299
57MP0001958_emphysema1.21069371
58MP0004233_abnormal_muscle_weight1.20369399
59MP0002396_abnormal_hematopoietic_system1.19035768
60MP0004130_abnormal_muscle_cell1.17210737
61MP0010155_abnormal_intestine_physiology1.16259112
62MP0010234_abnormal_vibrissa_follicle1.13962785
63MP0005670_abnormal_white_adipose1.11842035
64MP0003075_altered_response_to1.10207393
65MP0002398_abnormal_bone_marrow1.09988073
66MP0005464_abnormal_platelet_physiology1.08450713
67MP0002148_abnormal_hypersensitivity_rea1.06904102
68MP0000749_muscle_degeneration1.04846615
69MP0000716_abnormal_immune_system1.03174345
70MP0009785_altered_susceptibility_to1.02095244
71MP0002405_respiratory_system_inflammati1.01653385
72MP0000767_abnormal_smooth_muscle1.01475235
73MP0006082_CNS_inflammation0.99971646
74MP0000703_abnormal_thymus_morphology0.99844556
75MP0010630_abnormal_cardiac_muscle0.99492236
76MP0005390_skeleton_phenotype0.97805051
77MP0005330_cardiomyopathy0.95107386
78MP0000003_abnormal_adipose_tissue0.94900719
79MP0002933_joint_inflammation0.93274084
80MP0003045_fibrosis0.93068134
81MP0002796_impaired_skin_barrier0.92996488
82MP0005671_abnormal_response_to0.91813727
83MP0005023_abnormal_wound_healing0.91767844
84MP0001545_abnormal_hematopoietic_system0.91124611
85MP0005397_hematopoietic_system_phenotyp0.91124611
86MP0003329_amyloid_beta_deposits0.90591492
87MP0003183_abnormal_peptide_metabolism0.88942869
88MP0002429_abnormal_blood_cell0.87576041
89MP0002722_abnormal_immune_system0.87009664
90MP0002106_abnormal_muscle_physiology0.86195926
91MP0006138_congestive_heart_failure0.85181936
92MP0001851_eye_inflammation0.83540377
93MP0004808_abnormal_hematopoietic_stem0.83121541
94MP0001845_abnormal_inflammatory_respons0.82930373
95MP0005166_decreased_susceptibility_to0.81683798
96MP0004036_abnormal_muscle_relaxation0.77399278
97MP0003448_altered_tumor_morphology0.76966343
98MP0005310_abnormal_salivary_gland0.75712193
99MP0002060_abnormal_skin_morphology0.75452723
100MP0002332_abnormal_exercise_endurance0.74746341

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.58000566
2Increased connective tissue (HP:0009025)3.54805409
3Eczematoid dermatitis (HP:0000976)3.35816748
4Distal lower limb amyotrophy (HP:0008944)3.20431672
5Type 1 muscle fiber predominance (HP:0003803)3.13759625
6Myopathic facies (HP:0002058)3.07216408
7Distal lower limb muscle weakness (HP:0009053)3.06627765
8Exercise-induced myalgia (HP:0003738)3.06038663
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.02495966
10Increased variability in muscle fiber diameter (HP:0003557)2.90164650
11Abnormality of skeletal muscle fiber size (HP:0012084)2.89977166
12Broad face (HP:0000283)2.82697769
13Hyperacusis (HP:0010780)2.75938875
14Cerebral aneurysm (HP:0004944)2.73602936
15Muscle fiber inclusion bodies (HP:0100299)2.60866704
16Cellulitis (HP:0100658)2.57457402
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.54549742
18Round ear (HP:0100830)2.48937745
19Asymmetric septal hypertrophy (HP:0001670)2.48269944
20Easy fatigability (HP:0003388)2.47443065
21Protrusio acetabuli (HP:0003179)2.46936987
22Nemaline bodies (HP:0003798)2.45810195
23Abnormality of macrophages (HP:0004311)2.44762401
24Mildly elevated creatine phosphokinase (HP:0008180)2.36006316
25Stridor (HP:0010307)2.34722737
26Recurrent abscess formation (HP:0002722)2.33542350
27Achilles tendon contracture (HP:0001771)2.31639828
28Increased IgE level (HP:0003212)2.30067905
29Ulnar deviation of the wrist (HP:0003049)2.26018073
30Thin bony cortex (HP:0002753)2.25420290
31Difficulty climbing stairs (HP:0003551)2.24643921
32Difficulty running (HP:0009046)2.22127803
33Ulnar bowing (HP:0003031)2.21657913
34Bulbar palsy (HP:0001283)2.21305438
35Recurrent bacterial skin infections (HP:0005406)2.21162379
36Muscle fiber splitting (HP:0003555)2.20393629
37Lower limb amyotrophy (HP:0007210)2.20139110
38Hemorrhage of the eye (HP:0011885)2.19373687
39Dysostosis multiplex (HP:0000943)2.11646262
40Disproportionate tall stature (HP:0001519)2.11140516
41Chronic obstructive pulmonary disease (HP:0006510)2.07940856
42Obstructive lung disease (HP:0006536)2.07940856
43Upper limb amyotrophy (HP:0009129)2.07780287
44Distal upper limb amyotrophy (HP:0007149)2.07780287
45Slender build (HP:0001533)2.04821077
46Axonal loss (HP:0003447)2.03402552
47Vertebral compression fractures (HP:0002953)2.03332132
48Abnormality of the Achilles tendon (HP:0005109)2.02194340
49Hyporeflexia of lower limbs (HP:0002600)1.99102072
50Gingivitis (HP:0000230)1.96900417
51Myositis (HP:0100614)1.95770861
52Emphysema (HP:0002097)1.95647408
53Cervical subluxation (HP:0003308)1.94594829
54Spinal rigidity (HP:0003306)1.94177459
55Premature rupture of membranes (HP:0001788)1.92287688
56Fragile skin (HP:0001030)1.91288983
57Aneurysm (HP:0002617)1.90555738
58Colitis (HP:0002583)1.88316930
59Mitral regurgitation (HP:0001653)1.87906521
60Increased cerebral lipofuscin (HP:0011813)1.86642070
61Long palpebral fissure (HP:0000637)1.85895872
62Shallow orbits (HP:0000586)1.83539124
63Gastrointestinal inflammation (HP:0004386)1.83465932
64EMG: myopathic abnormalities (HP:0003458)1.82938242
65Abnormality of the fingertips (HP:0001211)1.81402002
66Spontaneous hematomas (HP:0007420)1.80635616
67Gastrointestinal infarctions (HP:0005244)1.80337974
68Mediastinal lymphadenopathy (HP:0100721)1.78709678
69Abnormality of the thoracic spine (HP:0100711)1.78288776
70Segmental peripheral demyelination/remyelination (HP:0003481)1.77068485
71Dilatation of the ascending aorta (HP:0005111)1.76545561
72Genu recurvatum (HP:0002816)1.75995190
73Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75866396
74Abnormality of polysaccharide metabolism (HP:0011012)1.75866396
75Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75866396
76Gastrointestinal stroma tumor (HP:0100723)1.74654925
77Polygenic inheritance (HP:0010982)1.74286549
78Abnormality of liposaccharide metabolism (HP:0010968)1.72265927
79Abnormality of glycosphingolipid metabolism (HP:0004343)1.72265927
80Abnormality of glycolipid metabolism (HP:0010969)1.72265927
81Metaphyseal cupping (HP:0003021)1.71652686
82Hypertriglyceridemia (HP:0002155)1.70269810
83Orchitis (HP:0100796)1.70103320
84Urinary glycosaminoglycan excretion (HP:0003541)1.69717854
85Mucopolysacchariduria (HP:0008155)1.69717854
86Meningitis (HP:0001287)1.69143963
87Generalized amyotrophy (HP:0003700)1.68895212
88Recurrent gram-negative bacterial infections (HP:0005420)1.68875419
89J-shaped sella turcica (HP:0002680)1.68614600
90Hypertensive crisis (HP:0100735)1.67999158
91Thin ribs (HP:0000883)1.66227266
92Loss of speech (HP:0002371)1.65787124
93Nuclear cataract (HP:0100018)1.64780127
94Slow saccadic eye movements (HP:0000514)1.62803379
95Hypercortisolism (HP:0001578)1.62144531
96Polycythemia (HP:0001901)1.61683488
97Annular pancreas (HP:0001734)1.60578833
98Blue sclerae (HP:0000592)1.60400978
99Joint stiffness (HP:0001387)1.60078179
100Inflammation of the large intestine (HP:0002037)1.59169069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.30979179
2PRPF4B3.63035629
3SIK13.62903996
4ERN13.37430659
5SMG12.55588332
6TTN2.43976934
7MAP4K12.34827624
8IRAK32.25843302
9MAP2K32.23667857
10ICK2.20350874
11RIPK41.95066887
12EEF2K1.87663276
13RIPK11.80988514
14CDK121.75177704
15IRAK41.70016371
16MAP3K101.67385654
17EPHB11.60360519
18TAOK21.55916577
19TAOK11.55671130
20MAP3K111.53832623
21TNK21.53403650
22MARK21.43075746
23PRKD21.37798475
24MAP3K131.37343609
25MAP3K31.36187961
26PKN21.30409898
27FGFR41.27287097
28EPHA21.25349132
29CDC42BPA1.22399949
30SIK21.19402113
31SIK31.18234915
32TBK11.16701387
33TYK21.15930702
34MAP3K11.15260615
35PTK61.15114623
36ZAP701.13818066
37IRAK21.11108914
38BLK1.07554354
39KSR21.03827021
40MAPK121.02169775
41MAP3K71.01893854
42CSK1.01481611
43GRK61.01302387
44NME20.95508252
45PRKD30.93768048
46HIPK20.93437502
47PDPK10.92009802
48MTOR0.86294252
49MAP3K140.85304036
50TESK10.85100722
51PDGFRA0.83799858
52RPS6KA20.81777914
53RPS6KC10.80313674
54RPS6KL10.80313674
55PAK40.79043074
56MAP3K60.78467150
57MST1R0.77986103
58FES0.77821839
59BTK0.72274495
60BMX0.70055276
61ARAF0.68479634
62JAK30.68290484
63MAPK70.67024605
64HCK0.66410792
65MAP2K20.66025093
66PDK10.64366731
67MAPK110.64360524
68TESK20.61961881
69LMTK20.61130209
70RPS6KA60.58691201
71DYRK1B0.56991898
72DDR20.56813539
73CSF1R0.56146582
74PRKG20.53668024
75CDK40.52224057
76PTK20.51591899
77OBSCN0.51221186
78CAMKK10.51167115
79MOS0.49657261
80PHKG20.47200533
81PHKG10.47200533
82MAPK40.46920248
83STK380.46798319
84JAK10.46499810
85MAP3K80.46146704
86LRRK20.46126343
87BRAF0.43602013
88IKBKE0.42782109
89MAP2K60.40845036
90FGR0.40538987
91SGK30.40077049
92MAPKAPK20.39370422
93DMPK0.38936334
94CAMK1D0.38241199
95RET0.38191116
96TYRO30.38172378
97IKBKB0.37890323
98CHUK0.37886138
99RPS6KA10.37472332
100IRAK10.36965741

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.29028617
2Acute myeloid leukemia_Homo sapiens_hsa052212.21040239
3Osteoclast differentiation_Homo sapiens_hsa043802.02786615
4B cell receptor signaling pathway_Homo sapiens_hsa046621.95804621
5Notch signaling pathway_Homo sapiens_hsa043301.95457902
6Chronic myeloid leukemia_Homo sapiens_hsa052201.83685450
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82578463
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74176719
9VEGF signaling pathway_Homo sapiens_hsa043701.71972597
10Non-small cell lung cancer_Homo sapiens_hsa052231.68139992
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67241579
12Leishmaniasis_Homo sapiens_hsa051401.63856703
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54302171
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47196933
15Pancreatic cancer_Homo sapiens_hsa052121.35927138
16Neurotrophin signaling pathway_Homo sapiens_hsa047221.35788381
17Bladder cancer_Homo sapiens_hsa052191.33797571
18Insulin signaling pathway_Homo sapiens_hsa049101.29381123
19Renal cell carcinoma_Homo sapiens_hsa052111.27256287
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25629217
21Tuberculosis_Homo sapiens_hsa051521.24708360
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.24588800
23Toxoplasmosis_Homo sapiens_hsa051451.22448672
24T cell receptor signaling pathway_Homo sapiens_hsa046601.21494400
25Endometrial cancer_Homo sapiens_hsa052131.20815290
26TNF signaling pathway_Homo sapiens_hsa046681.20025561
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.19358294
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.18095699
29mTOR signaling pathway_Homo sapiens_hsa041501.16668726
30GnRH signaling pathway_Homo sapiens_hsa049121.16331401
31Prion diseases_Homo sapiens_hsa050201.10822953
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09621284
33Pentose phosphate pathway_Homo sapiens_hsa000301.08581499
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.07586793
35Hepatitis B_Homo sapiens_hsa051611.07430992
36Influenza A_Homo sapiens_hsa051641.06951434
37Glioma_Homo sapiens_hsa052141.06349981
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.05982449
39Hepatitis C_Homo sapiens_hsa051601.05936397
40Malaria_Homo sapiens_hsa051441.04276080
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03981448
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03059690
43Viral myocarditis_Homo sapiens_hsa054161.02171029
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.01859458
45Insulin resistance_Homo sapiens_hsa049311.01838041
46Fructose and mannose metabolism_Homo sapiens_hsa000511.00377890
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99654063
48Amoebiasis_Homo sapiens_hsa051460.99313266
49ErbB signaling pathway_Homo sapiens_hsa040120.98464400
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97397743
51Staphylococcus aureus infection_Homo sapiens_hsa051500.97017040
52Focal adhesion_Homo sapiens_hsa045100.95619389
53Chemokine signaling pathway_Homo sapiens_hsa040620.95563159
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92922598
55Prolactin signaling pathway_Homo sapiens_hsa049170.92251650
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91472483
57Thyroid cancer_Homo sapiens_hsa052160.90874537
58Measles_Homo sapiens_hsa051620.89673020
59Lysosome_Homo sapiens_hsa041420.88471430
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88300058
61Choline metabolism in cancer_Homo sapiens_hsa052310.88292287
62Apoptosis_Homo sapiens_hsa042100.87600545
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87407705
64Endocytosis_Homo sapiens_hsa041440.86828798
65AMPK signaling pathway_Homo sapiens_hsa041520.86744782
66Estrogen signaling pathway_Homo sapiens_hsa049150.84759183
67Salmonella infection_Homo sapiens_hsa051320.83720948
68HTLV-I infection_Homo sapiens_hsa051660.83357644
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81296822
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.80574706
71Herpes simplex infection_Homo sapiens_hsa051680.80172338
72Platelet activation_Homo sapiens_hsa046110.78829126
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78605696
74Shigellosis_Homo sapiens_hsa051310.78594642
75Colorectal cancer_Homo sapiens_hsa052100.76952119
76Long-term potentiation_Homo sapiens_hsa047200.76632630
77Galactose metabolism_Homo sapiens_hsa000520.75379559
78Prostate cancer_Homo sapiens_hsa052150.74141277
79Inositol phosphate metabolism_Homo sapiens_hsa005620.73706721
80MAPK signaling pathway_Homo sapiens_hsa040100.73135120
81Proteoglycans in cancer_Homo sapiens_hsa052050.72375221
82Pertussis_Homo sapiens_hsa051330.71665682
83Dilated cardiomyopathy_Homo sapiens_hsa054140.69237844
84HIF-1 signaling pathway_Homo sapiens_hsa040660.68673215
85FoxO signaling pathway_Homo sapiens_hsa040680.67113411
86Small cell lung cancer_Homo sapiens_hsa052220.66211197
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65867158
88Primary immunodeficiency_Homo sapiens_hsa053400.65447526
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.65079049
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65047997
91Allograft rejection_Homo sapiens_hsa053300.64560741
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63354743
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60724754
94Viral carcinogenesis_Homo sapiens_hsa052030.57436221
95Rap1 signaling pathway_Homo sapiens_hsa040150.55670591
96Graft-versus-host disease_Homo sapiens_hsa053320.55419336
97Autoimmune thyroid disease_Homo sapiens_hsa053200.55399354
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.54220258
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54168853
100African trypanosomiasis_Homo sapiens_hsa051430.53332467

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