ZNF853

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)4.96301761
2synaptic vesicle docking involved in exocytosis (GO:0016081)4.61200509
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.45049593
4synaptic vesicle maturation (GO:0016188)4.42362185
5cellular potassium ion homeostasis (GO:0030007)4.13938236
6regulation of synaptic vesicle exocytosis (GO:2000300)4.11816594
7sarcoplasmic reticulum calcium ion transport (GO:0070296)4.10447696
8glutamate secretion (GO:0014047)4.03015625
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.96238462
10sodium ion export (GO:0071436)3.86387037
11cerebellar granule cell differentiation (GO:0021707)3.85007379
12muscle filament sliding (GO:0030049)3.79659547
13actin-myosin filament sliding (GO:0033275)3.79659547
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.79069516
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73825717
16positive regulation of synapse maturation (GO:0090129)3.62958843
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62167642
18synaptic vesicle exocytosis (GO:0016079)3.61471075
19cell communication by electrical coupling (GO:0010644)3.58696621
20neuronal action potential propagation (GO:0019227)3.54212759
21locomotory exploration behavior (GO:0035641)3.51083143
22regulation of synaptic vesicle transport (GO:1902803)3.49461874
23neuron cell-cell adhesion (GO:0007158)3.48775270
24central nervous system myelination (GO:0022010)3.44821542
25axon ensheathment in central nervous system (GO:0032291)3.44821542
26potassium ion homeostasis (GO:0055075)3.40586913
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39488278
28presynaptic membrane assembly (GO:0097105)3.37199190
29cell migration in hindbrain (GO:0021535)3.29362144
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.29197913
31regulation of neuronal synaptic plasticity (GO:0048168)3.28806709
32neurotransmitter-gated ion channel clustering (GO:0072578)3.25849473
33regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.25058811
34myofibril assembly (GO:0030239)3.20776068
35L-amino acid import (GO:0043092)3.20324508
36exploration behavior (GO:0035640)3.20126177
37neuromuscular process controlling balance (GO:0050885)3.18355591
38vocalization behavior (GO:0071625)3.17453418
39neuronal ion channel clustering (GO:0045161)3.17234572
40potassium ion import (GO:0010107)3.14937204
41presynaptic membrane organization (GO:0097090)3.14803417
42neurotransmitter secretion (GO:0007269)3.13983819
43cardiac myofibril assembly (GO:0055003)3.11796728
44creatine metabolic process (GO:0006600)3.11458205
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11155241
46regulation of actin filament-based movement (GO:1903115)3.08630851
47regulation of glutamate receptor signaling pathway (GO:1900449)3.07146444
48protein localization to synapse (GO:0035418)3.05087142
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04492522
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.04361736
51striated muscle contraction (GO:0006941)3.04253732
52regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.04019808
53dendritic spine morphogenesis (GO:0060997)3.03489014
54establishment of mitochondrion localization (GO:0051654)3.02858523
55actin-mediated cell contraction (GO:0070252)3.00169972
56amino acid import (GO:0043090)3.00040912
57regulation of synapse maturation (GO:0090128)2.99662069
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95470759
59skeletal muscle contraction (GO:0003009)2.95414125
60cardiac muscle contraction (GO:0060048)2.95281469
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94760441
62regulation of synapse structural plasticity (GO:0051823)2.94722067
63neuromuscular synaptic transmission (GO:0007274)2.93504149
64positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91427607
65positive regulation of dendritic spine development (GO:0060999)2.88132315
66regulation of relaxation of muscle (GO:1901077)2.86526468
67response to parathyroid hormone (GO:0071107)2.85820331
68cardiac muscle hypertrophy in response to stress (GO:0014898)2.85483471
69muscle hypertrophy in response to stress (GO:0003299)2.85483471
70cardiac muscle adaptation (GO:0014887)2.85483471
71response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.85225204
72synaptic transmission, glutamatergic (GO:0035249)2.83298408
73skeletal muscle fiber development (GO:0048741)2.81300035
74axonal fasciculation (GO:0007413)2.80888936
75layer formation in cerebral cortex (GO:0021819)2.79908055
76activation of protein kinase A activity (GO:0034199)2.79393545
77cellular sodium ion homeostasis (GO:0006883)2.78226419
78cardiac muscle hypertrophy (GO:0003300)2.72751183
79regulation of skeletal muscle contraction (GO:0014819)2.72713902
80astrocyte differentiation (GO:0048708)2.72207627
81regulation of respiratory system process (GO:0044065)2.71879340
82regulation of cell communication by electrical coupling (GO:0010649)2.71668167
83neuron recognition (GO:0008038)2.71213124
84cerebellar Purkinje cell layer development (GO:0021680)2.67114797
85auditory behavior (GO:0031223)2.65356977
86peripheral nervous system axon ensheathment (GO:0032292)2.64670727
87myelination in peripheral nervous system (GO:0022011)2.64670727
88regulation of skeletal muscle cell differentiation (GO:2001014)2.64405965
89regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64106931
90striated muscle hypertrophy (GO:0014897)2.63989467
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63221273
92mitochondrion transport along microtubule (GO:0047497)2.62971191
93establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62971191
94cell communication involved in cardiac conduction (GO:0086065)2.60704191
95regulation of membrane repolarization (GO:0060306)2.59681460
96negative regulation of catenin import into nucleus (GO:0035414)2.58712405
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57142655
98regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.55894253
99regulation of synaptic plasticity (GO:0048167)2.54162242
100cellular response to catecholamine stimulus (GO:0071870)2.51526312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.55387403
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.96879113
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78567128
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74870924
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74870924
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.69983729
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.67772760
8DROSHA_22980978_ChIP-Seq_HELA_Human2.66666452
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61007472
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59672498
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58001640
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56494330
13RNF2_27304074_Chip-Seq_ESCs_Mouse2.53679672
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.43047966
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36405196
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33657450
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.32934980
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32331424
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31693317
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23380649
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.20836416
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18568830
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15893816
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14930436
25ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11336336
26REST_21632747_ChIP-Seq_MESCs_Mouse2.04712210
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.97521590
28KDM2B_26808549_Chip-Seq_K562_Human1.94118719
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88232620
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86878299
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85568209
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79800247
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.78987201
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.71257694
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66696611
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.65084883
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64103424
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63789813
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62309550
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59741295
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59238594
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56834349
43CTCF_27219007_Chip-Seq_Bcells_Human1.54460532
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.52649030
45OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.49897205
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.43986173
47* LXR_22292898_ChIP-Seq_THP-1_Human1.43149054
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37400562
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33449785
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.31683407
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31020663
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30855181
53KDM2B_26808549_Chip-Seq_DND41_Human1.29821450
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28442367
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28346187
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21734039
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18675177
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16954792
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.16154205
60GBX2_23144817_ChIP-Seq_PC3_Human1.15958742
61TET1_21490601_ChIP-Seq_MESCs_Mouse1.13478949
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.10326455
63SMC4_20622854_ChIP-Seq_HELA_Human1.09788279
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06294765
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.04756252
66AR_21572438_ChIP-Seq_LNCaP_Human1.04165677
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03829063
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02512637
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02236860
70AR_19668381_ChIP-Seq_PC3_Human1.00081030
71YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99701970
72ISL1_27105846_Chip-Seq_CPCs_Mouse0.96570557
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96075990
74RNF2_27304074_Chip-Seq_NSC_Mouse0.95900025
75TBX20_22080862_ChIP-Seq_HEART_Mouse0.95712967
76TBX20_22328084_ChIP-Seq_HEART_Mouse0.95712967
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95553992
78CREB1_26743006_Chip-Seq_LNCaP_Human0.93519461
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92558958
80DPY_21335234_ChIP-Seq_ESCs_Mouse0.92373294
81NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91647555
82MYC_27129775_Chip-Seq_CORNEA_Mouse0.90228291
83RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89987349
84CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88818713
85TP53_23651856_ChIP-Seq_MEFs_Mouse0.88464429
86* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87880269
87SOX3_22085726_ChIP-Seq_NPCs_Mouse0.87681867
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85613304
89POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85549191
90TCF7_22412390_ChIP-Seq_EML_Mouse0.85288930
91GATA1_26923725_Chip-Seq_HPCs_Mouse0.85271104
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84798827
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84639286
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83825267
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83193915
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83132226
97OCT4_19829295_ChIP-Seq_ESCs_Human0.82001603
98* KLF4_19829295_ChIP-Seq_ESCs_Human0.80702930
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80006871
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.77865697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.06741915
2MP0004270_analgesia3.46583364
3MP0000751_myopathy3.02330597
4MP0005423_abnormal_somatic_nervous3.00507209
5MP0003635_abnormal_synaptic_transmissio2.89054921
6MP0003880_abnormal_central_pattern2.53830686
7MP0004145_abnormal_muscle_electrophysio2.45842725
8MP0002063_abnormal_learning/memory/cond2.32682304
9MP0002064_seizures2.31840172
10MP0002734_abnormal_mechanical_nocicepti2.21660568
11MP0002822_catalepsy2.16912617
12MP0000749_muscle_degeneration2.10169960
13MP0003329_amyloid_beta_deposits2.07814923
14MP0000778_abnormal_nervous_system2.04447846
15MP0008569_lethality_at_weaning1.90955346
16MP0009745_abnormal_behavioral_response1.90718903
17MP0001486_abnormal_startle_reflex1.90073556
18MP0003646_muscle_fatigue1.86688565
19MP0004885_abnormal_endolymph1.84615176
20MP0004130_abnormal_muscle_cell1.84248638
21MP0002272_abnormal_nervous_system1.83240282
22MP0002572_abnormal_emotion/affect_behav1.81935498
23MP0003122_maternal_imprinting1.79456669
24MP0003283_abnormal_digestive_organ1.74923375
25MP0000747_muscle_weakness1.73916797
26MP0009780_abnormal_chondrocyte_physiolo1.73324807
27MP0002106_abnormal_muscle_physiology1.70606643
28MP0001502_abnormal_circadian_rhythm1.64172715
29MP0004087_abnormal_muscle_fiber1.61525849
30MP0000955_abnormal_spinal_cord1.60360198
31MP0004036_abnormal_muscle_relaxation1.60125514
32MP0003879_abnormal_hair_cell1.52595979
33MP0005369_muscle_phenotype1.52030884
34MP0000759_abnormal_skeletal_muscle1.51591206
35MP0002249_abnormal_larynx_morphology1.51411017
36MP0003690_abnormal_glial_cell1.46538768
37MP0002638_abnormal_pupillary_reflex1.40798246
38MP0002735_abnormal_chemical_nociception1.37211829
39MP0004811_abnormal_neuron_physiology1.33381634
40MP0000566_synostosis1.33035663
41MP0001970_abnormal_pain_threshold1.32629811
42MP0003123_paternal_imprinting1.32394620
43MP0005620_abnormal_muscle_contractility1.29098841
44MP0001984_abnormal_olfaction1.28658648
45MP0003634_abnormal_glial_cell1.28323027
46MP0002557_abnormal_social/conspecific_i1.27451439
47MP0002882_abnormal_neuron_morphology1.25494043
48MP0001968_abnormal_touch/_nociception1.25160605
49MP0001299_abnormal_eye_distance/1.24436153
50MP0004858_abnormal_nervous_system1.22507359
51MP0006276_abnormal_autonomic_nervous1.21205639
52MP0002066_abnormal_motor_capabilities/c1.20591493
53MP0002733_abnormal_thermal_nociception1.18216736
54MP0002184_abnormal_innervation1.17410119
55MP0002067_abnormal_sensory_capabilities1.16810423
56MP0002269_muscular_atrophy1.14745467
57MP0002653_abnormal_ependyma_morphology1.13849433
58MP0003633_abnormal_nervous_system1.12779883
59MP0003136_yellow_coat_color1.12714832
60MP0000920_abnormal_myelination1.11531209
61MP0001440_abnormal_grooming_behavior1.10459134
62MP0002152_abnormal_brain_morphology1.09768348
63MP0009046_muscle_twitch1.09590672
64MP0002108_abnormal_muscle_morphology1.07431769
65MP0000534_abnormal_ureter_morphology1.06944606
66MP0000750_abnormal_muscle_regeneration1.06530148
67MP0002736_abnormal_nociception_after1.03981424
68MP0010630_abnormal_cardiac_muscle1.00745780
69MP0003631_nervous_system_phenotype0.99684832
70MP0005646_abnormal_pituitary_gland0.99148282
71MP0004233_abnormal_muscle_weight0.98619748
72MP0003787_abnormal_imprinting0.98200456
73MP0000733_abnormal_muscle_development0.97889767
74MP0005409_darkened_coat_color0.96952886
75MP0004084_abnormal_cardiac_muscle0.94183992
76MP0002909_abnormal_adrenal_gland0.92176743
77MP0003942_abnormal_urinary_system0.91326839
78MP0002972_abnormal_cardiac_muscle0.90844946
79MP0003632_abnormal_nervous_system0.90469176
80MP0003705_abnormal_hypodermis_morpholog0.89566147
81MP0005386_behavior/neurological_phenoty0.88494730
82MP0004924_abnormal_behavior0.88494730
83MP0003861_abnormal_nervous_system0.86716969
84MP0001346_abnormal_lacrimal_gland0.86706792
85MP0001501_abnormal_sleep_pattern0.85544156
86MP0000579_abnormal_nail_morphology0.84686278
87MP0003137_abnormal_impulse_conducting0.82922309
88MP0005623_abnormal_meninges_morphology0.80732435
89MP0006138_congestive_heart_failure0.79404243
90MP0002127_abnormal_cardiovascular_syste0.78964397
91MP0001963_abnormal_hearing_physiology0.78102103
92MP0000049_abnormal_middle_ear0.77893294
93MP0001177_atelectasis0.77768604
94MP0002752_abnormal_somatic_nervous0.73507144
95MP0005330_cardiomyopathy0.72680056
96MP0000026_abnormal_inner_ear0.72363409
97MP0001943_abnormal_respiration0.72221215
98MP0003567_abnormal_fetal_cardiomyocyte0.68745887
99MP0002116_abnormal_craniofacial_bone0.68419045
100MP0002332_abnormal_exercise_endurance0.67517407

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.21985969
2Nemaline bodies (HP:0003798)5.07813209
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.03243817
4Type 1 muscle fiber predominance (HP:0003803)4.69418318
5Exercise-induced myalgia (HP:0003738)4.40570556
6Obstructive sleep apnea (HP:0002870)4.15370010
7Exercise-induced muscle cramps (HP:0003710)3.62228711
8Myokymia (HP:0002411)3.42872522
9Myopathic facies (HP:0002058)3.41005013
10Hyporeflexia of lower limbs (HP:0002600)3.18321221
11Abnormality of the left ventricular outflow tract (HP:0011103)3.18260388
12Subaortic stenosis (HP:0001682)3.18260388
13Focal motor seizures (HP:0011153)3.18126594
14Distal arthrogryposis (HP:0005684)3.16092602
15Muscle fiber splitting (HP:0003555)3.12126801
16Ankle clonus (HP:0011448)3.09453691
17Muscle hypertrophy of the lower extremities (HP:0008968)3.05134886
18EMG: myopathic abnormalities (HP:0003458)3.00552048
19Round ear (HP:0100830)2.98545622
20Difficulty running (HP:0009046)2.92279968
21Abnormality of skeletal muscle fiber size (HP:0012084)2.86396982
22Neurofibrillary tangles (HP:0002185)2.86247880
23Calcaneovalgus deformity (HP:0001848)2.85422050
24Turricephaly (HP:0000262)2.83279149
25Increased variability in muscle fiber diameter (HP:0003557)2.80261854
26Calf muscle hypertrophy (HP:0008981)2.78773466
27Action tremor (HP:0002345)2.74834261
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.73697104
29Focal seizures (HP:0007359)2.69157543
30Bundle branch block (HP:0011710)2.63733343
31Fetal akinesia sequence (HP:0001989)2.48202859
32Abnormality of the calf musculature (HP:0001430)2.45585604
33Deformed tarsal bones (HP:0008119)2.43574578
34EMG: neuropathic changes (HP:0003445)2.40752162
35Diplopia (HP:0000651)2.39185967
36Abnormality of binocular vision (HP:0011514)2.39185967
37Sleep apnea (HP:0010535)2.35618044
38Frequent falls (HP:0002359)2.34973206
39Cerebral inclusion bodies (HP:0100314)2.31159299
40Sudden death (HP:0001699)2.30799089
41Aplasia involving bones of the extremities (HP:0009825)2.29152290
42Aplasia involving bones of the upper limbs (HP:0009823)2.29152290
43Aplasia of the phalanges of the hand (HP:0009802)2.29152290
44Generalized tonic-clonic seizures (HP:0002069)2.24971174
45Myotonia (HP:0002486)2.24204487
46Febrile seizures (HP:0002373)2.21925957
47Urinary bladder sphincter dysfunction (HP:0002839)2.21377454
48Hyperacusis (HP:0010780)2.19692963
49Abnormality of the aortic arch (HP:0012303)2.17628201
50Epileptic encephalopathy (HP:0200134)2.15587128
51Megalencephaly (HP:0001355)2.13821009
52Neck muscle weakness (HP:0000467)2.13589555
53Myoglobinuria (HP:0002913)2.13329910
54Spastic gait (HP:0002064)2.12658708
55Rimmed vacuoles (HP:0003805)2.12599775
56Akinesia (HP:0002304)2.10310891
57Abnormality of the foot musculature (HP:0001436)2.10165245
58Supranuclear gaze palsy (HP:0000605)2.09709290
59Ulnar deviation of the wrist (HP:0003049)2.06565663
60Insomnia (HP:0100785)2.04385492
61Lower limb amyotrophy (HP:0007210)2.01928973
62Foot dorsiflexor weakness (HP:0009027)2.01821109
63Hypercortisolism (HP:0001578)1.96929259
64Muscle stiffness (HP:0003552)1.96680806
65Asymmetric septal hypertrophy (HP:0001670)1.95335049
66Atonic seizures (HP:0010819)1.94397612
67Vertebral arch anomaly (HP:0008438)1.94142259
68Absent phalangeal crease (HP:0006109)1.93141772
69Split foot (HP:0001839)1.92408416
70Shallow orbits (HP:0000586)1.90045957
71Heart block (HP:0012722)1.89725208
72Abnormality of the lower motor neuron (HP:0002366)1.87817771
73Anomalous pulmonary venous return (HP:0010772)1.84889713
74Mitral regurgitation (HP:0001653)1.81112517
75Abnormal ventriculo-arterial connection (HP:0011563)1.80422690
76Transposition of the great arteries (HP:0001669)1.80422690
77Abnormal connection of the cardiac segments (HP:0011545)1.80422690
78Scapular winging (HP:0003691)1.79197526
79Rhabdomyolysis (HP:0003201)1.78259249
80Mildly elevated creatine phosphokinase (HP:0008180)1.76215908
81Urinary urgency (HP:0000012)1.75825847
82Annular pancreas (HP:0001734)1.75692821
83Hemiplegia (HP:0002301)1.75456452
84Limb dystonia (HP:0002451)1.74827740
85Germ cell neoplasia (HP:0100728)1.74813530
86Lower limb muscle weakness (HP:0007340)1.73405017
87Papilledema (HP:0001085)1.73312003
88Adducted thumb (HP:0001181)1.72858190
89Hypoventilation (HP:0002791)1.72636587
90Bulbar palsy (HP:0001283)1.72378553
91Hemiparesis (HP:0001269)1.72201445
92Truncal ataxia (HP:0002078)1.72008880
93Bronchomalacia (HP:0002780)1.70783841
94Abnormal eating behavior (HP:0100738)1.70463353
95Peripheral hypomyelination (HP:0007182)1.69104998
96Abnormal atrioventricular conduction (HP:0005150)1.69005687
97Abnormality of the calcaneus (HP:0008364)1.68674171
98Infantile muscular hypotonia (HP:0008947)1.68558481
99Abnormality of the corticospinal tract (HP:0002492)1.68487258
100Ventricular fibrillation (HP:0001663)1.68299918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.21770470
2PHKG23.74092615
3PHKG13.74092615
4OBSCN3.49080898
5NTRK22.79278102
6NTRK32.74004423
7NTRK12.51710414
8TTN2.51514559
9CASK2.44425795
10EPHA42.39696822
11PAK62.38402276
12UHMK12.23078709
13TYRO32.19350400
14PRKD31.99596981
15RIPK11.89009808
16TRIB31.59373338
17MAPK121.49034979
18SGK2231.47611036
19SGK4941.47611036
20MARK21.40232243
21LATS21.36524578
22PRPF4B1.34198546
23SIK21.33485727
24DAPK21.28139443
25MAP3K91.27026360
26SGK21.23726941
27SGK31.20978034
28CAMKK11.20264784
29KSR21.19994980
30PINK11.16990856
31ICK1.16769553
32MAP2K41.15232537
33PKN11.15145086
34DMPK1.14127180
35EEF2K1.13845007
36TNIK1.12789911
37MAP3K71.10313643
38CDK51.09384773
39FGFR21.09227865
40SGK11.02995499
41MINK11.02887569
42PDGFRA1.02868490
43CAMK2B0.96539714
44CAMK2G0.95460509
45RET0.95387208
46MAPK130.89187521
47MAPK150.88213429
48DYRK1B0.86739678
49CAMK10.86646025
50FGFR40.86380878
51CAMK40.85617382
52STK110.83378055
53EPHB20.81903894
54ROCK20.78893207
55DYRK1A0.78778858
56CDK190.78047720
57MAPK100.77784086
58PRKCH0.76821732
59CAMK2A0.70979391
60PNCK0.67077886
61ARAF0.66990741
62FGFR30.66328535
63MOS0.63762545
64ROCK10.62589857
65CDK150.61658241
66PRKCG0.61412865
67CDK11A0.59408484
68RPS6KA30.58135400
69SIK10.57006895
70DYRK20.56555939
71TNK20.56221979
72CAMK2D0.55094526
73CDK180.53570316
74KSR10.53007057
75RPS6KA20.52435770
76MAP3K40.51801948
77NEK60.50884711
78STK380.50506214
79MAP3K100.48786839
80CDK140.48495984
81PTK20.47100285
82RPS6KB10.46765910
83MTOR0.46643990
84PRKCZ0.46591441
85CAMK1G0.46168476
86PDPK10.44209559
87PRKAA10.44025048
88MAP2K30.43223617
89FES0.42318644
90PLK20.41941270
91MAP3K60.41769683
92MAP3K130.40955025
93DDR20.40666329
94PAK30.40225135
95ALK0.39032362
96MAPK40.38252608
97AKT20.37435207
98PRKG10.37398480
99MAP3K10.35472456
100ERBB20.34207926

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.32943251
2Nicotine addiction_Homo sapiens_hsa050332.11402944
3Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.10046841
4Insulin secretion_Homo sapiens_hsa049112.03608936
5Circadian entrainment_Homo sapiens_hsa047132.02947622
6Dilated cardiomyopathy_Homo sapiens_hsa054141.98563294
7Synaptic vesicle cycle_Homo sapiens_hsa047211.93129535
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90239685
9Amphetamine addiction_Homo sapiens_hsa050311.88998251
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85257357
11Gastric acid secretion_Homo sapiens_hsa049711.82743315
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78788533
13Glutamatergic synapse_Homo sapiens_hsa047241.76384825
14GABAergic synapse_Homo sapiens_hsa047271.71779449
15Oxytocin signaling pathway_Homo sapiens_hsa049211.65921417
16Cardiac muscle contraction_Homo sapiens_hsa042601.60865092
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59046238
18Cholinergic synapse_Homo sapiens_hsa047251.56704095
19Cocaine addiction_Homo sapiens_hsa050301.54300560
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54073716
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52463959
22Dopaminergic synapse_Homo sapiens_hsa047281.51046016
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45549899
24Morphine addiction_Homo sapiens_hsa050321.43447978
25Calcium signaling pathway_Homo sapiens_hsa040201.43397077
26Notch signaling pathway_Homo sapiens_hsa043301.35872908
27cAMP signaling pathway_Homo sapiens_hsa040241.35380477
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34583342
29Melanogenesis_Homo sapiens_hsa049161.34499725
30Renin secretion_Homo sapiens_hsa049241.34395266
31Axon guidance_Homo sapiens_hsa043601.33504969
32GnRH signaling pathway_Homo sapiens_hsa049121.33372562
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.33134790
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32409062
35Glioma_Homo sapiens_hsa052141.29383686
36Insulin signaling pathway_Homo sapiens_hsa049101.21462431
37ErbB signaling pathway_Homo sapiens_hsa040121.17689616
38Glucagon signaling pathway_Homo sapiens_hsa049221.16693123
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.15096716
40Estrogen signaling pathway_Homo sapiens_hsa049151.13658193
41Salivary secretion_Homo sapiens_hsa049701.13436563
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.10179024
43Gap junction_Homo sapiens_hsa045401.09715437
44Long-term depression_Homo sapiens_hsa047301.09467086
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09095567
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07145477
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06469706
48Prion diseases_Homo sapiens_hsa050201.03963335
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03765401
50VEGF signaling pathway_Homo sapiens_hsa043701.03606049
51Circadian rhythm_Homo sapiens_hsa047101.02536699
52Endometrial cancer_Homo sapiens_hsa052130.98708711
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98482737
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97056212
55Renal cell carcinoma_Homo sapiens_hsa052110.95385275
56MAPK signaling pathway_Homo sapiens_hsa040100.93762693
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93114212
58AMPK signaling pathway_Homo sapiens_hsa041520.92774899
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.92245031
60Wnt signaling pathway_Homo sapiens_hsa043100.91445690
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88289594
62Choline metabolism in cancer_Homo sapiens_hsa052310.87271464
63Dorso-ventral axis formation_Homo sapiens_hsa043200.87043243
64Basal cell carcinoma_Homo sapiens_hsa052170.86095533
65mTOR signaling pathway_Homo sapiens_hsa041500.85376907
66Type II diabetes mellitus_Homo sapiens_hsa049300.84385894
67Bile secretion_Homo sapiens_hsa049760.83604198
68Hippo signaling pathway_Homo sapiens_hsa043900.83305428
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82476697
70Tight junction_Homo sapiens_hsa045300.80921192
71Sulfur relay system_Homo sapiens_hsa041220.80826341
72Hedgehog signaling pathway_Homo sapiens_hsa043400.80692770
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79945660
74Arginine and proline metabolism_Homo sapiens_hsa003300.79782330
75Rap1 signaling pathway_Homo sapiens_hsa040150.78504933
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78332914
77Ras signaling pathway_Homo sapiens_hsa040140.73174605
78Focal adhesion_Homo sapiens_hsa045100.70970402
79Inositol phosphate metabolism_Homo sapiens_hsa005620.70694422
80Thyroid hormone synthesis_Homo sapiens_hsa049180.70426842
81Non-small cell lung cancer_Homo sapiens_hsa052230.68982100
82Adherens junction_Homo sapiens_hsa045200.68071185
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67995922
84Pancreatic secretion_Homo sapiens_hsa049720.67873861
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.62517472
86Colorectal cancer_Homo sapiens_hsa052100.61585228
87Taste transduction_Homo sapiens_hsa047420.60792660
88Serotonergic synapse_Homo sapiens_hsa047260.60307118
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59713698
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55569745
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.52588356
92Arginine biosynthesis_Homo sapiens_hsa002200.52527047
93Olfactory transduction_Homo sapiens_hsa047400.50607739
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50592101
95ECM-receptor interaction_Homo sapiens_hsa045120.49464741
96Oocyte meiosis_Homo sapiens_hsa041140.48930683
97Protein digestion and absorption_Homo sapiens_hsa049740.48154134
98Endocytosis_Homo sapiens_hsa041440.46848835
99Insulin resistance_Homo sapiens_hsa049310.45565466
100Prolactin signaling pathway_Homo sapiens_hsa049170.45509456

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