ZNF85

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.82535308
2DNA replication checkpoint (GO:0000076)4.22096601
3chromatin remodeling at centromere (GO:0031055)4.11484396
4CENP-A containing nucleosome assembly (GO:0034080)3.91727780
5regulation of nuclear cell cycle DNA replication (GO:0033262)3.86564593
6behavioral response to nicotine (GO:0035095)3.69885719
7histone exchange (GO:0043486)3.50228206
8replication fork processing (GO:0031297)3.45748441
9regulation of mitotic spindle checkpoint (GO:1903504)3.42720754
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42720754
11neural tube formation (GO:0001841)3.32544496
12water-soluble vitamin biosynthetic process (GO:0042364)3.28568636
13negative regulation of DNA-dependent DNA replication (GO:2000104)3.27616952
14platelet dense granule organization (GO:0060155)3.26247444
15DNA catabolic process, exonucleolytic (GO:0000738)3.22113233
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.20457002
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20457002
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17846127
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17846127
20respiratory chain complex IV assembly (GO:0008535)3.17033581
21somite development (GO:0061053)3.16648451
22centriole replication (GO:0007099)3.11643503
23recombinational repair (GO:0000725)3.10961498
24protein complex biogenesis (GO:0070271)3.10042320
25regulation of meiosis I (GO:0060631)3.09753439
26double-strand break repair via homologous recombination (GO:0000724)3.09236091
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.08930972
28NADH dehydrogenase complex assembly (GO:0010257)3.08930972
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08930972
30negative regulation of transcription regulatory region DNA binding (GO:2000678)3.08694974
31response to pheromone (GO:0019236)3.05181107
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02746965
33nonmotile primary cilium assembly (GO:0035058)3.02496798
34regulation of DNA endoreduplication (GO:0032875)3.02149769
35L-fucose catabolic process (GO:0042355)3.01647760
36fucose catabolic process (GO:0019317)3.01647760
37L-fucose metabolic process (GO:0042354)3.01647760
38intraciliary transport (GO:0042073)2.97680992
39negative regulation of telomere maintenance (GO:0032205)2.96864183
40mitochondrial respiratory chain complex assembly (GO:0033108)2.96398138
41piRNA metabolic process (GO:0034587)2.96170695
42DNA deamination (GO:0045006)2.95793490
43mitochondrial DNA replication (GO:0006264)2.94864649
44postreplication repair (GO:0006301)2.91666056
45reciprocal meiotic recombination (GO:0007131)2.88662768
46reciprocal DNA recombination (GO:0035825)2.88662768
47regulation of helicase activity (GO:0051095)2.88410378
48synapsis (GO:0007129)2.87655412
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85616585
50DNA replication-independent nucleosome organization (GO:0034724)2.84378203
51DNA replication-independent nucleosome assembly (GO:0006336)2.84378203
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82868269
53protein-cofactor linkage (GO:0018065)2.82510831
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82303331
55kinetochore organization (GO:0051383)2.78157342
56cytochrome complex assembly (GO:0017004)2.75857668
57translesion synthesis (GO:0019985)2.75319848
58neuron fate determination (GO:0048664)2.71633737
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68146874
60kinetochore assembly (GO:0051382)2.64375358
61protein neddylation (GO:0045116)2.61786474
62DNA replication-dependent nucleosome organization (GO:0034723)2.61286473
63DNA replication-dependent nucleosome assembly (GO:0006335)2.61286473
64cilium morphogenesis (GO:0060271)2.60664389
65cullin deneddylation (GO:0010388)2.58645981
66indole-containing compound catabolic process (GO:0042436)2.58597909
67indolalkylamine catabolic process (GO:0046218)2.58597909
68tryptophan catabolic process (GO:0006569)2.58597909
69limb bud formation (GO:0060174)2.57597520
70atrial cardiac muscle cell action potential (GO:0086014)2.57585020
71epithelial cilium movement (GO:0003351)2.55072369
72cornea development in camera-type eye (GO:0061303)2.54763050
73indolalkylamine metabolic process (GO:0006586)2.53358010
74protein K6-linked ubiquitination (GO:0085020)2.52922901
75preassembly of GPI anchor in ER membrane (GO:0016254)2.52907238
76DNA-dependent DNA replication (GO:0006261)2.52699690
77establishment of protein localization to mitochondrial membrane (GO:0090151)2.52347612
78regulation of telomere maintenance (GO:0032204)2.52077749
79meiotic chromosome segregation (GO:0045132)2.51679153
80cilium organization (GO:0044782)2.51416074
81microtubule depolymerization (GO:0007019)2.50950003
82resolution of meiotic recombination intermediates (GO:0000712)2.50892872
83pyrimidine nucleobase catabolic process (GO:0006208)2.50030549
84regulation of mesoderm development (GO:2000380)2.49881637
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48754054
86histone H2A acetylation (GO:0043968)2.47059998
87cilium assembly (GO:0042384)2.46818006
88somite rostral/caudal axis specification (GO:0032525)2.46380571
89presynaptic membrane assembly (GO:0097105)2.46095766
90kidney morphogenesis (GO:0060993)2.44964865
91kynurenine metabolic process (GO:0070189)2.42979842
92adenosine metabolic process (GO:0046085)2.42553150
93protein deneddylation (GO:0000338)2.42414270
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41544071
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.41544071
96isotype switching (GO:0045190)2.41544071
97male meiosis (GO:0007140)2.40425041
98mannosylation (GO:0097502)2.39951900
99negative regulation of DNA recombination (GO:0045910)2.39832676
100male meiosis I (GO:0007141)2.39042084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.82046982
2VDR_22108803_ChIP-Seq_LS180_Human2.98824360
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.90723087
4IGF1R_20145208_ChIP-Seq_DFB_Human2.84023271
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80262985
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77585425
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67820092
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61402819
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61105178
10EWS_26573619_Chip-Seq_HEK293_Human2.49255349
11FUS_26573619_Chip-Seq_HEK293_Human2.45060993
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44362743
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38636496
14GBX2_23144817_ChIP-Seq_PC3_Human2.37876235
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37368634
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.37001313
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34731234
18TAF15_26573619_Chip-Seq_HEK293_Human2.30219545
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.27857764
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.21457406
21P300_19829295_ChIP-Seq_ESCs_Human2.14090599
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02668146
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01054072
24ELK1_19687146_ChIP-ChIP_HELA_Human1.97091360
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93865372
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89851168
27E2F7_22180533_ChIP-Seq_HELA_Human1.89804297
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87161619
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69960572
30EZH2_22144423_ChIP-Seq_EOC_Human1.68930647
31IRF1_19129219_ChIP-ChIP_H3396_Human1.67433087
32MYC_18940864_ChIP-ChIP_HL60_Human1.65319399
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60869167
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.58771539
35ER_23166858_ChIP-Seq_MCF-7_Human1.57994272
36VDR_23849224_ChIP-Seq_CD4+_Human1.53430998
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49514058
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49315816
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47647509
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45434994
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44097600
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40304132
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.34915494
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34686276
45BCAT_22108803_ChIP-Seq_LS180_Human1.34499445
46TP53_22573176_ChIP-Seq_HFKS_Human1.33638626
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33609006
48SMAD4_21799915_ChIP-Seq_A2780_Human1.31659491
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.30390943
50AR_25329375_ChIP-Seq_VCAP_Human1.30384376
51CBP_20019798_ChIP-Seq_JUKART_Human1.29876010
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29876010
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28517621
54RNF2_27304074_Chip-Seq_NSC_Mouse1.27961465
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.27854110
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26938614
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26643387
58SOX2_19829295_ChIP-Seq_ESCs_Human1.26354843
59NANOG_19829295_ChIP-Seq_ESCs_Human1.26354843
60STAT3_23295773_ChIP-Seq_U87_Human1.26319367
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25906399
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25003882
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24924015
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.23358326
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22716501
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22405247
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21018128
68RUNX2_22187159_ChIP-Seq_PCA_Human1.18438446
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15057245
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14843171
71FOXP3_21729870_ChIP-Seq_TREG_Human1.13461842
72TCF4_22108803_ChIP-Seq_LS180_Human1.12511057
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11627170
74* TCF4_23295773_ChIP-Seq_U87_Human1.11516600
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11196766
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.10164313
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.09566959
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09209765
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09209765
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08620300
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08279765
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07543687
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.07543687
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06539594
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06402305
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06155284
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.05887047
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05882222
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.05747407
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04794799
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03590804
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.02443241
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.01756488
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01530993
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.99979965
96P53_22387025_ChIP-Seq_ESCs_Mouse0.98285582
97* NCOR_22424771_ChIP-Seq_293T_Human0.96138479
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.95823959
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95577872
100JUN_21703547_ChIP-Seq_K562_Human0.92534194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.95052979
2MP0008057_abnormal_DNA_replication3.42209260
3MP0006292_abnormal_olfactory_placode3.39792056
4MP0008058_abnormal_DNA_repair2.49719954
5MP0002102_abnormal_ear_morphology2.37600581
6MP0003195_calcinosis2.34525100
7MP0002234_abnormal_pharynx_morphology2.33635348
8MP0010094_abnormal_chromosome_stability2.20440289
9MP0006072_abnormal_retinal_apoptosis2.10400097
10MP0004133_heterotaxia2.05995976
11MP0003787_abnormal_imprinting2.03563735
12MP0008789_abnormal_olfactory_epithelium2.00488979
13MP0008995_early_reproductive_senescence1.99342712
14MP0002938_white_spotting1.97297796
15MP0003880_abnormal_central_pattern1.90922263
16MP0005551_abnormal_eye_electrophysiolog1.89219493
17MP0001529_abnormal_vocalization1.86669984
18MP0000631_abnormal_neuroendocrine_gland1.82076112
19MP0005645_abnormal_hypothalamus_physiol1.81411865
20MP0003693_abnormal_embryo_hatching1.75750282
21MP0003121_genomic_imprinting1.70714520
22MP0004147_increased_porphyrin_level1.68246526
23MP0003890_abnormal_embryonic-extraembry1.66065981
24MP0005253_abnormal_eye_physiology1.63560256
25MP0005394_taste/olfaction_phenotype1.63345077
26MP0005499_abnormal_olfactory_system1.63345077
27MP0000372_irregular_coat_pigmentation1.61431302
28MP0003136_yellow_coat_color1.59611178
29MP0005646_abnormal_pituitary_gland1.58312191
30MP0002751_abnormal_autonomic_nervous1.56875912
31MP0003122_maternal_imprinting1.55908962
32MP0003718_maternal_effect1.52371966
33MP0000569_abnormal_digit_pigmentation1.50974383
34MP0002638_abnormal_pupillary_reflex1.50240069
35MP0001485_abnormal_pinna_reflex1.49705530
36MP0001293_anophthalmia1.48943066
37MP0001984_abnormal_olfaction1.47781815
38MP0006276_abnormal_autonomic_nervous1.43404318
39MP0002736_abnormal_nociception_after1.40869844
40MP0003567_abnormal_fetal_cardiomyocyte1.38522145
41MP0003786_premature_aging1.38208606
42MP0003119_abnormal_digestive_system1.37363576
43MP0000427_abnormal_hair_cycle1.36060904
44MP0002837_dystrophic_cardiac_calcinosis1.30677442
45MP0005084_abnormal_gallbladder_morpholo1.27815175
46MP0001968_abnormal_touch/_nociception1.25126308
47MP0002163_abnormal_gland_morphology1.23240646
48MP0000516_abnormal_urinary_system1.22425000
49MP0005367_renal/urinary_system_phenotyp1.22425000
50MP0008872_abnormal_physiological_respon1.21368995
51MP0000778_abnormal_nervous_system1.21289392
52MP0002653_abnormal_ependyma_morphology1.20416646
53MP0009046_muscle_twitch1.17956938
54MP0009745_abnormal_behavioral_response1.17369088
55MP0003937_abnormal_limbs/digits/tail_de1.17270604
56MP0004142_abnormal_muscle_tone1.16758236
57MP0002210_abnormal_sex_determination1.15696477
58MP0001929_abnormal_gametogenesis1.12035030
59MP0001986_abnormal_taste_sensitivity1.11834862
60MP0004885_abnormal_endolymph1.09530714
61MP0003011_delayed_dark_adaptation1.07196115
62MP0004215_abnormal_myocardial_fiber1.06931372
63MP0003137_abnormal_impulse_conducting1.06395809
64MP0002272_abnormal_nervous_system1.06214537
65MP0001486_abnormal_startle_reflex1.04984126
66MP0001188_hyperpigmentation1.04544605
67MP0002254_reproductive_system_inflammat1.04240575
68MP0000647_abnormal_sebaceous_gland1.03148895
69MP0000653_abnormal_sex_gland1.00273434
70MP0005075_abnormal_melanosome_morpholog0.99857196
71MP0000049_abnormal_middle_ear0.95295854
72MP0005195_abnormal_posterior_eye0.95288019
73MP0005379_endocrine/exocrine_gland_phen0.95132862
74MP0005391_vision/eye_phenotype0.94809826
75MP0001145_abnormal_male_reproductive0.94747098
76MP0009697_abnormal_copulation0.94154557
77MP0003646_muscle_fatigue0.93987370
78MP0003698_abnormal_male_reproductive0.93019595
79MP0000383_abnormal_hair_follicle0.91828135
80MP0002233_abnormal_nose_morphology0.89340016
81MP0002160_abnormal_reproductive_system0.88905018
82MP0001764_abnormal_homeostasis0.88197631
83MP0002752_abnormal_somatic_nervous0.86550905
84MP0001286_abnormal_eye_development0.86491552
85MP0003283_abnormal_digestive_organ0.85575532
86MP0002184_abnormal_innervation0.84891285
87MP0002735_abnormal_chemical_nociception0.84333381
88MP0001324_abnormal_eye_pigmentation0.83598155
89MP0004957_abnormal_blastocyst_morpholog0.81480295
90MP0002572_abnormal_emotion/affect_behav0.80312112
91MP0005389_reproductive_system_phenotype0.79791304
92MP0000026_abnormal_inner_ear0.77948069
93MP0002095_abnormal_skin_pigmentation0.77499642
94MP0001119_abnormal_female_reproductive0.77022273
95MP0002876_abnormal_thyroid_physiology0.76814397
96MP0005174_abnormal_tail_pigmentation0.75490714
97MP0003938_abnormal_ear_development0.74667861
98MP0004043_abnormal_pH_regulation0.74282974
99MP0002557_abnormal_social/conspecific_i0.74160747
100MP0008932_abnormal_embryonic_tissue0.72826722

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.44282180
2Pancreatic cysts (HP:0001737)3.41845498
3Molar tooth sign on MRI (HP:0002419)3.34398397
4Abnormality of midbrain morphology (HP:0002418)3.34398397
5True hermaphroditism (HP:0010459)3.22857425
6Nephronophthisis (HP:0000090)3.16803021
7Abnormality of the labia minora (HP:0012880)3.11371594
8Medial flaring of the eyebrow (HP:0010747)2.95606502
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88415246
10Abnormality of alanine metabolism (HP:0010916)2.88415246
11Hyperalaninemia (HP:0003348)2.88415246
12Birth length less than 3rd percentile (HP:0003561)2.85019359
13Colon cancer (HP:0003003)2.83546196
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.77661185
15Congenital stationary night blindness (HP:0007642)2.73811334
16Meckel diverticulum (HP:0002245)2.69169808
17Ectopic kidney (HP:0000086)2.67269679
18Abnormality of the renal medulla (HP:0100957)2.65357289
19Abnormality of the ileum (HP:0001549)2.59169270
20Abnormality of chromosome stability (HP:0003220)2.50179310
21Thyroid-stimulating hormone excess (HP:0002925)2.48257943
22Methylmalonic acidemia (HP:0002912)2.45504220
23Abolished electroretinogram (ERG) (HP:0000550)2.38991932
24Abnormality of the renal cortex (HP:0011035)2.38586341
25Hyperglycinemia (HP:0002154)2.37856256
26Congenital primary aphakia (HP:0007707)2.37502412
27Intestinal atresia (HP:0011100)2.37436596
28Gait imbalance (HP:0002141)2.35682445
29Chromsome breakage (HP:0040012)2.31779816
30Nephrogenic diabetes insipidus (HP:0009806)2.27349607
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.26483250
32Progressive inability to walk (HP:0002505)2.23937256
33Pendular nystagmus (HP:0012043)2.23238098
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21192520
35Genital tract atresia (HP:0001827)2.21022886
36Septo-optic dysplasia (HP:0100842)2.15152769
37Type II lissencephaly (HP:0007260)2.14562798
38Chronic hepatic failure (HP:0100626)2.12544878
39Attenuation of retinal blood vessels (HP:0007843)2.12163186
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.11581755
41Vaginal atresia (HP:0000148)2.07961486
42Inability to walk (HP:0002540)2.07939135
43Sclerocornea (HP:0000647)2.04343617
44Small intestinal stenosis (HP:0012848)2.03742565
45Duodenal stenosis (HP:0100867)2.03742565
46Abnormality of the preputium (HP:0100587)2.02431389
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02272293
48Exertional dyspnea (HP:0002875)2.01441498
49Optic nerve hypoplasia (HP:0000609)2.00769515
50Abnormality of the duodenum (HP:0002246)2.00653238
51Cystic liver disease (HP:0006706)1.97960994
52Supernumerary spleens (HP:0009799)1.97676748
53Anencephaly (HP:0002323)1.97397655
54Sloping forehead (HP:0000340)1.97281331
55Abnormality of serum amino acid levels (HP:0003112)1.96904649
56Abnormality of B cell number (HP:0010975)1.96534680
57Hyperventilation (HP:0002883)1.93981011
58Thyroiditis (HP:0100646)1.93203624
59Methylmalonic aciduria (HP:0012120)1.92771544
60Postaxial foot polydactyly (HP:0001830)1.92636851
61Lissencephaly (HP:0001339)1.91470179
62Acute necrotizing encephalopathy (HP:0006965)1.91408630
63Mitochondrial inheritance (HP:0001427)1.91244156
64Renal cortical cysts (HP:0000803)1.88095049
65Increased CSF lactate (HP:0002490)1.88047234
66Small hand (HP:0200055)1.87923732
67Constricted visual fields (HP:0001133)1.87883286
68Clubbing of toes (HP:0100760)1.87841202
69Hypothermia (HP:0002045)1.87632112
70Tubular atrophy (HP:0000092)1.86906344
71Oligodactyly (hands) (HP:0001180)1.85698524
72Short tibia (HP:0005736)1.85349842
73Progressive macrocephaly (HP:0004481)1.85110349
74Postaxial hand polydactyly (HP:0001162)1.84903524
75Astigmatism (HP:0000483)1.84750451
76Increased hepatocellular lipid droplets (HP:0006565)1.83714062
77Volvulus (HP:0002580)1.81380477
78B lymphocytopenia (HP:0010976)1.80887552
79Abnormality of serine family amino acid metabolism (HP:0010894)1.80724953
80Abnormality of glycine metabolism (HP:0010895)1.80724953
813-Methylglutaconic aciduria (HP:0003535)1.79028823
82Acute encephalopathy (HP:0006846)1.78962610
83Disproportionate short-trunk short stature (HP:0003521)1.78233687
84Bile duct proliferation (HP:0001408)1.78208694
85Abnormal biliary tract physiology (HP:0012439)1.78208694
86Congenital, generalized hypertrichosis (HP:0004540)1.78120334
87Male pseudohermaphroditism (HP:0000037)1.77750381
88Triphalangeal thumb (HP:0001199)1.77483668
89Dandy-Walker malformation (HP:0001305)1.77470801
90Patellar aplasia (HP:0006443)1.76337604
91Lipid accumulation in hepatocytes (HP:0006561)1.74686399
92Congenital hepatic fibrosis (HP:0002612)1.73557813
93Hepatocellular necrosis (HP:0001404)1.71806045
94Preaxial hand polydactyly (HP:0001177)1.67877386
95Narrow forehead (HP:0000341)1.67074840
96Poor coordination (HP:0002370)1.66621702
97Hyperglycinuria (HP:0003108)1.66516291
98Abnormality of the carotid arteries (HP:0005344)1.66261104
99Furrowed tongue (HP:0000221)1.65675775
100Neoplasm of the adrenal gland (HP:0100631)1.65183164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.06778983
2BMPR1B3.21687140
3TRIM282.90339097
4WNK32.71273135
5ZAK2.65135335
6ACVR1B2.51657508
7TNIK2.44177342
8NUAK12.36173090
9MKNK22.30366757
10ERBB32.18964622
11BRSK21.84140165
12MAP4K21.81739842
13GRK11.80153826
14CASK1.70443152
15INSRR1.68864983
16CDC71.66511555
17WEE11.61546960
18MKNK11.60938965
19MAP3K41.59471699
20ADRBK21.59408384
21TAF11.59229956
22TLK11.57308792
23PLK41.52047435
24PINK11.51675814
25PNCK1.51220989
26PLK31.47027704
27MST41.46328352
28BCR1.43972190
29MAPK131.40576943
30VRK11.39885067
31TSSK61.28732007
32SRPK11.28018422
33BCKDK1.26599643
34DYRK21.22862174
35VRK21.20009577
36OXSR11.18932000
37TGFBR11.10096018
38CAMKK21.03091381
39MAP2K71.00130057
40PLK20.99295399
41BUB10.98487080
42DYRK30.97671125
43NEK20.97194855
44NEK10.95857292
45PLK10.95263693
46CSNK1G10.93804645
47TIE10.92312533
48EPHA40.92239184
49TXK0.91573758
50TTK0.89919282
51CSNK1G20.89848624
52STK390.87666556
53CSNK1G30.84570200
54PBK0.84359088
55EIF2AK30.82809266
56STK38L0.80761754
57CDK190.80623794
58CDK30.80334654
59NLK0.80176445
60PRKCE0.80071942
61MUSK0.78505727
62STK160.77109397
63PRKCG0.75847687
64ATR0.73960650
65PAK30.73941622
66WNK40.71973040
67RPS6KA40.71800068
68SIK30.69798440
69CSNK1A1L0.69509415
70PIK3CA0.69037321
71ADRBK10.62176236
72FGFR20.61477113
73STK30.61355055
74CHEK20.61151683
75PASK0.59013109
76ATM0.58464568
77NTRK20.55535509
78CCNB10.54449663
79TEC0.49265377
80DAPK20.48806907
81BRSK10.46211575
82CAMK1G0.46012830
83RPS6KA50.44147321
84CSNK1A10.43465096
85MARK10.38702588
86NTRK30.38374684
87TAOK30.37115682
88CSNK2A10.36804865
89AURKB0.34678560
90CAMK10.34109972
91CSNK1D0.33619078
92EIF2AK20.33596822
93CAMK2A0.33586931
94MINK10.32770608
95CAMK1D0.32140786
96PRKACA0.31988901
97STK110.30792524
98NME10.30016210
99OBSCN0.28793666
100PTK2B0.26514715

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11051329
2Homologous recombination_Homo sapiens_hsa034402.84884185
3Protein export_Homo sapiens_hsa030602.82724387
4Non-homologous end-joining_Homo sapiens_hsa034502.73453604
5Fanconi anemia pathway_Homo sapiens_hsa034602.69665804
6Basal transcription factors_Homo sapiens_hsa030222.40560418
7Mismatch repair_Homo sapiens_hsa034302.33853147
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22559784
9Butanoate metabolism_Homo sapiens_hsa006502.19921881
10RNA polymerase_Homo sapiens_hsa030202.19296799
11Phototransduction_Homo sapiens_hsa047442.16756297
12Oxidative phosphorylation_Homo sapiens_hsa001902.03576226
13DNA replication_Homo sapiens_hsa030301.96215886
14Propanoate metabolism_Homo sapiens_hsa006401.95488354
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91804401
16RNA degradation_Homo sapiens_hsa030181.88665137
17Selenocompound metabolism_Homo sapiens_hsa004501.87221298
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79557137
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78669661
20Proteasome_Homo sapiens_hsa030501.74697353
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68604885
22Nicotine addiction_Homo sapiens_hsa050331.66769019
23Parkinsons disease_Homo sapiens_hsa050121.61061106
24One carbon pool by folate_Homo sapiens_hsa006701.59302058
25Steroid biosynthesis_Homo sapiens_hsa001001.53948425
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.53631822
27Nucleotide excision repair_Homo sapiens_hsa034201.51022340
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48875663
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47856383
30Caffeine metabolism_Homo sapiens_hsa002321.47053598
31Linoleic acid metabolism_Homo sapiens_hsa005911.45959921
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40627372
33Ether lipid metabolism_Homo sapiens_hsa005651.36746668
34RNA transport_Homo sapiens_hsa030131.34616042
35Base excision repair_Homo sapiens_hsa034101.29793610
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28497434
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28385118
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28276970
39Nitrogen metabolism_Homo sapiens_hsa009101.22947043
40Tryptophan metabolism_Homo sapiens_hsa003801.19049945
41Huntingtons disease_Homo sapiens_hsa050161.13820815
42Peroxisome_Homo sapiens_hsa041461.11455046
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05872028
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.05324220
45Taste transduction_Homo sapiens_hsa047421.02749277
46Fatty acid elongation_Homo sapiens_hsa000621.02676286
47Spliceosome_Homo sapiens_hsa030401.01323445
48Purine metabolism_Homo sapiens_hsa002300.99020803
49Pyrimidine metabolism_Homo sapiens_hsa002400.98470642
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98273539
51Olfactory transduction_Homo sapiens_hsa047400.93979701
52Cell cycle_Homo sapiens_hsa041100.93979620
53Regulation of autophagy_Homo sapiens_hsa041400.90981738
54Alzheimers disease_Homo sapiens_hsa050100.83789797
55mRNA surveillance pathway_Homo sapiens_hsa030150.78472543
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77395710
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76827223
58GABAergic synapse_Homo sapiens_hsa047270.73804191
59Retinol metabolism_Homo sapiens_hsa008300.73141499
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72366933
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72105622
62Metabolic pathways_Homo sapiens_hsa011000.71981195
63beta-Alanine metabolism_Homo sapiens_hsa004100.71140453
64Morphine addiction_Homo sapiens_hsa050320.71010015
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.70301607
66Hedgehog signaling pathway_Homo sapiens_hsa043400.69394714
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68442228
68Basal cell carcinoma_Homo sapiens_hsa052170.67094358
69Cardiac muscle contraction_Homo sapiens_hsa042600.66281041
70Serotonergic synapse_Homo sapiens_hsa047260.63772978
71Chemical carcinogenesis_Homo sapiens_hsa052040.62819120
72Oocyte meiosis_Homo sapiens_hsa041140.61671431
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61210795
74Ribosome_Homo sapiens_hsa030100.60061831
75Folate biosynthesis_Homo sapiens_hsa007900.59018836
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.58230999
77Collecting duct acid secretion_Homo sapiens_hsa049660.55398265
78Pyruvate metabolism_Homo sapiens_hsa006200.55278978
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52586603
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50147921
81p53 signaling pathway_Homo sapiens_hsa041150.49308765
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47909962
83Circadian entrainment_Homo sapiens_hsa047130.47756347
84Glutamatergic synapse_Homo sapiens_hsa047240.47307234
85Vitamin B6 metabolism_Homo sapiens_hsa007500.46398845
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46303563
87Insulin secretion_Homo sapiens_hsa049110.43979865
88Sulfur metabolism_Homo sapiens_hsa009200.43177017
89ABC transporters_Homo sapiens_hsa020100.43131679
90Primary immunodeficiency_Homo sapiens_hsa053400.40862532
91Glycerolipid metabolism_Homo sapiens_hsa005610.39690407
92Glutathione metabolism_Homo sapiens_hsa004800.39145749
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38511693
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37297682
95Arachidonic acid metabolism_Homo sapiens_hsa005900.37200213
96Dopaminergic synapse_Homo sapiens_hsa047280.36775088
97Hippo signaling pathway_Homo sapiens_hsa043900.34871641
98Lysine degradation_Homo sapiens_hsa003100.34340207
99Fatty acid metabolism_Homo sapiens_hsa012120.33693237
100Circadian rhythm_Homo sapiens_hsa047100.32424743

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