ZNF845

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.73461194
2nuclear pore organization (GO:0006999)5.24933384
3ribosome assembly (GO:0042255)4.44044203
4mitotic sister chromatid cohesion (GO:0007064)4.24522105
5pore complex assembly (GO:0046931)4.16280624
6positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.07510033
7positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.07510033
8positive regulation of mitotic sister chromatid separation (GO:1901970)4.07510033
9regulation of centriole replication (GO:0046599)3.84763551
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.78686053
11regulation of mitotic spindle checkpoint (GO:1903504)3.78686053
12regulation of helicase activity (GO:0051095)3.78318865
13DNA double-strand break processing (GO:0000729)3.74624171
14mitotic metaphase plate congression (GO:0007080)3.67676356
15regulation of gene silencing by RNA (GO:0060966)3.64262727
16regulation of posttranscriptional gene silencing (GO:0060147)3.64262727
17regulation of gene silencing by miRNA (GO:0060964)3.64262727
18mitotic G2/M transition checkpoint (GO:0044818)3.53177689
19somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.52904115
20isotype switching (GO:0045190)3.52904115
21somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.52904115
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.49408900
23positive regulation of chromosome segregation (GO:0051984)3.49006122
24regulation of DNA endoreduplication (GO:0032875)3.46797986
25protein localization to kinetochore (GO:0034501)3.46510084
26pre-miRNA processing (GO:0031054)3.43204515
27CENP-A containing nucleosome assembly (GO:0034080)3.41764070
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.40718242
29somatic hypermutation of immunoglobulin genes (GO:0016446)3.40718242
30metaphase plate congression (GO:0051310)3.38252895
31prenylation (GO:0097354)3.35941537
32protein prenylation (GO:0018342)3.35941537
33spindle checkpoint (GO:0031577)3.35386272
34chromatin remodeling at centromere (GO:0031055)3.33532167
35mitotic G2 DNA damage checkpoint (GO:0007095)3.33032394
36establishment of integrated proviral latency (GO:0075713)3.31818136
37regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27396642
38regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27396642
39mitotic spindle checkpoint (GO:0071174)3.26009722
40histone mRNA metabolic process (GO:0008334)3.25967769
41double-strand break repair via nonhomologous end joining (GO:0006303)3.24535532
42non-recombinational repair (GO:0000726)3.24535532
43regulation of sister chromatid segregation (GO:0033045)3.19604902
44regulation of mitotic sister chromatid separation (GO:0010965)3.19604902
45regulation of mitotic sister chromatid segregation (GO:0033047)3.19604902
46somatic recombination of immunoglobulin gene segments (GO:0016447)3.18503053
47DNA replication-dependent nucleosome organization (GO:0034723)3.17746732
48DNA replication-dependent nucleosome assembly (GO:0006335)3.17746732
49response to X-ray (GO:0010165)3.16158218
50intra-S DNA damage checkpoint (GO:0031573)3.11790028
51protein K11-linked deubiquitination (GO:0035871)3.11732377
52negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11441027
53negative regulation of translation, ncRNA-mediated (GO:0040033)3.11441027
54regulation of translation, ncRNA-mediated (GO:0045974)3.11441027
55response to UV-C (GO:0010225)3.10555339
56somatic cell DNA recombination (GO:0016444)3.10335551
57somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.10335551
58protein localization to chromosome, centromeric region (GO:0071459)3.08833767
59regulation of retinoic acid receptor signaling pathway (GO:0048385)3.08307784
60negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.07674311
61establishment of chromosome localization (GO:0051303)3.06024119
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.04889464
63negative regulation of sister chromatid segregation (GO:0033046)3.04889464
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04889464
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04889464
66negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04889464
67histone exchange (GO:0043486)3.01995484
68somatic diversification of immunoglobulins (GO:0016445)3.01937982
69negative regulation of chromosome segregation (GO:0051985)3.00678926
70somatic diversification of immune receptors (GO:0002200)2.99052514
71DNA strand elongation involved in DNA replication (GO:0006271)2.97969606
72DNA replication checkpoint (GO:0000076)2.97123626
73replication fork processing (GO:0031297)2.95691530
74attachment of spindle microtubules to kinetochore (GO:0008608)2.95669937
75DNA strand elongation (GO:0022616)2.94771224
76mitotic nuclear envelope disassembly (GO:0007077)2.94305998
77mitochondrial DNA replication (GO:0006264)2.92558582
78regulation of chromosome segregation (GO:0051983)2.91355032
79COPII vesicle coating (GO:0048208)2.90189785
80postreplication repair (GO:0006301)2.87086475
81inner cell mass cell proliferation (GO:0001833)2.87022044
82telomere maintenance via semi-conservative replication (GO:0032201)2.86897513
83regulation of histone H3-K9 methylation (GO:0051570)2.84838003
84pseudouridine synthesis (GO:0001522)2.84628696
85resolution of meiotic recombination intermediates (GO:0000712)2.83783059
86nucleotide-excision repair, DNA gap filling (GO:0006297)2.83664178
87lactate metabolic process (GO:0006089)2.83589294
88mitotic recombination (GO:0006312)2.82029412
89mRNA cleavage (GO:0006379)2.81515573
90telomere maintenance (GO:0000723)2.80494340
91negative regulation of DNA recombination (GO:0045910)2.80108694
92cullin deneddylation (GO:0010388)2.80028568
93regulation of DNA damage checkpoint (GO:2000001)2.77667940
94telomere organization (GO:0032200)2.77419461
95DNA ligation (GO:0006266)2.76962325
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76544916
97maturation of 5.8S rRNA (GO:0000460)2.76395300
98telomere maintenance via recombination (GO:0000722)2.76063698
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75879500
100DNA catabolic process, exonucleolytic (GO:0000738)2.72921590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.47350400
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.88231450
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69830474
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29122038
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.23766928
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.92877688
7ELK1_19687146_ChIP-ChIP_HELA_Human2.76616417
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.55318894
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46383581
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33029713
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.33007560
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24759950
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23481652
14VDR_23849224_ChIP-Seq_CD4+_Human2.18767143
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.15794490
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08394159
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07116868
18PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05419800
19ZNF274_21170338_ChIP-Seq_K562_Hela2.03005178
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00378973
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99103149
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95689471
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94349690
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88313998
25EWS_26573619_Chip-Seq_HEK293_Human1.84925974
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.84711788
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82732451
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81644668
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80305579
30FOXP3_21729870_ChIP-Seq_TREG_Human1.74156671
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71225577
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.60715724
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57760690
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55318038
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.54006356
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52379707
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49123526
38AR_21909140_ChIP-Seq_LNCAP_Human1.47597998
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45804365
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.44759585
41FUS_26573619_Chip-Seq_HEK293_Human1.44501715
42DCP1A_22483619_ChIP-Seq_HELA_Human1.42765481
43MYC_18940864_ChIP-ChIP_HL60_Human1.42384761
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33087646
45P300_19829295_ChIP-Seq_ESCs_Human1.30696805
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30176136
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29462035
48IGF1R_20145208_ChIP-Seq_DFB_Human1.28762493
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.23923832
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.23123441
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21775963
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21463707
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20889903
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20830721
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.17602933
56TAF15_26573619_Chip-Seq_HEK293_Human1.16228039
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14724253
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14724253
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14724253
60ER_23166858_ChIP-Seq_MCF-7_Human1.12104120
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11324718
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06896898
63CBP_20019798_ChIP-Seq_JUKART_Human1.06896898
64GBX2_23144817_ChIP-Seq_PC3_Human1.06761269
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05726941
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04874320
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04252971
68IRF1_19129219_ChIP-ChIP_H3396_Human1.04221883
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01903015
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01635974
71SALL4_22934838_ChIP-ChIP_CD34+_Human1.01426356
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00802747
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99512827
74VDR_22108803_ChIP-Seq_LS180_Human0.99449538
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99121632
76TFEB_21752829_ChIP-Seq_HELA_Human0.95815649
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95705083
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94162302
79SRF_21415370_ChIP-Seq_HL-1_Mouse0.92025568
80GABP_19822575_ChIP-Seq_HepG2_Human0.91221911
81ELF5_23300383_ChIP-Seq_T47D_Human0.90196182
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89610634
83SOX2_16153702_ChIP-ChIP_HESCs_Human0.88252997
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87612235
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.87313348
86SMAD_19615063_ChIP-ChIP_OVARY_Human0.87155358
87GATA3_26560356_Chip-Seq_TH2_Human0.87049449
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86114904
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86016309
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85863865
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85478772
92P300_18555785_Chip-Seq_ESCs_Mouse0.84195535
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83916042
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83193607
95E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82127002
96BRD4_25478319_ChIP-Seq_HGPS_Human0.82072863
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81957727
98FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81629880
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81504716
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81382128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.25346196
2MP0010094_abnormal_chromosome_stability3.64699091
3MP0008877_abnormal_DNA_methylation3.59709964
4MP0003890_abnormal_embryonic-extraembry3.55240151
5MP0008058_abnormal_DNA_repair3.37265516
6MP0010352_gastrointestinal_tract_polyps3.16881356
7MP0003693_abnormal_embryo_hatching3.07990118
8MP0004957_abnormal_blastocyst_morpholog2.91502414
9MP0003077_abnormal_cell_cycle2.86087395
10MP0003111_abnormal_nucleus_morphology2.75685461
11MP0010307_abnormal_tumor_latency2.62818550
12MP0002254_reproductive_system_inflammat2.50223399
13MP0000569_abnormal_digit_pigmentation2.32188027
14MP0010234_abnormal_vibrissa_follicle2.24875406
15MP0003718_maternal_effect2.21927573
16MP0009697_abnormal_copulation2.08416537
17MP0003941_abnormal_skin_development2.06281909
18MP0008007_abnormal_cellular_replicative1.98121956
19MP0003567_abnormal_fetal_cardiomyocyte1.93000319
20MP0008932_abnormal_embryonic_tissue1.91748020
21MP0006054_spinal_hemorrhage1.90972731
22MP0004147_increased_porphyrin_level1.90443900
23MP0005075_abnormal_melanosome_morpholog1.72768516
24MP0003786_premature_aging1.68430599
25MP0006072_abnormal_retinal_apoptosis1.57613973
26MP0002166_altered_tumor_susceptibility1.53958121
27MP0002009_preneoplasia1.46418153
28MP0001730_embryonic_growth_arrest1.38684015
29MP0002006_tumorigenesis1.36819006
30MP0001697_abnormal_embryo_size1.34553291
31MP0002396_abnormal_hematopoietic_system1.31784110
32MP0005380_embryogenesis_phenotype1.28433543
33MP0001672_abnormal_embryogenesis/_devel1.28433543
34MP0002102_abnormal_ear_morphology1.28168432
35MP0001764_abnormal_homeostasis1.27028904
36MP0000350_abnormal_cell_proliferation1.26790149
37MP0003221_abnormal_cardiomyocyte_apopto1.21287175
38MP0009703_decreased_birth_body1.19992867
39MP0004197_abnormal_fetal_growth/weight/1.18751891
40MP0006035_abnormal_mitochondrial_morpho1.18633717
41MP0005084_abnormal_gallbladder_morpholo1.18540236
42MP0002163_abnormal_gland_morphology1.14457293
43MP0003984_embryonic_growth_retardation1.10198032
44MP0005647_abnormal_sex_gland1.09758862
45MP0002088_abnormal_embryonic_growth/wei1.08998265
46MP0005389_reproductive_system_phenotype1.07762545
47MP0003763_abnormal_thymus_physiology1.06722567
48MP0001919_abnormal_reproductive_system1.06691628
49MP0008995_early_reproductive_senescence1.06671875
50MP0002084_abnormal_developmental_patter1.06079972
51MP0003806_abnormal_nucleotide_metabolis1.04058893
52MP0002086_abnormal_extraembryonic_tissu1.03678256
53MP0010678_abnormal_skin_adnexa1.02984656
54MP0002160_abnormal_reproductive_system1.02205211
55MP0005671_abnormal_response_to1.01032352
56MP0000358_abnormal_cell_content/0.99648425
57MP0001661_extended_life_span0.97874324
58MP0004084_abnormal_cardiac_muscle0.97141996
59MP0004185_abnormal_adipocyte_glucose0.96445992
60MP0001929_abnormal_gametogenesis0.95666800
61MP0003787_abnormal_imprinting0.93190637
62MP0005645_abnormal_hypothalamus_physiol0.92269010
63MP0001119_abnormal_female_reproductive0.90850691
64MP0002019_abnormal_tumor_incidence0.90457415
65MP0005395_other_phenotype0.88982417
66MP0002138_abnormal_hepatobiliary_system0.88504192
67MP0000689_abnormal_spleen_morphology0.88072102
68MP0000653_abnormal_sex_gland0.86211389
69MP0001293_anophthalmia0.85290145
70MP0003828_pulmonary_edema0.84744934
71MP0001145_abnormal_male_reproductive0.83877617
72MP0002085_abnormal_embryonic_tissue0.83687790
73MP0009333_abnormal_splenocyte_physiolog0.83494827
74MP0000427_abnormal_hair_cycle0.83139510
75MP0003252_abnormal_bile_duct0.82971518
76MP0000313_abnormal_cell_death0.81969418
77MP0002080_prenatal_lethality0.81662980
78MP0002210_abnormal_sex_determination0.80840563
79MP0000703_abnormal_thymus_morphology0.79520505
80MP0001191_abnormal_skin_condition0.79169418
81MP0002090_abnormal_vision0.78601573
82MP0003937_abnormal_limbs/digits/tail_de0.77668641
83MP0000015_abnormal_ear_pigmentation0.76741477
84MP0009672_abnormal_birth_weight0.75873067
85MP0005379_endocrine/exocrine_gland_phen0.74384567
86MP0002722_abnormal_immune_system0.72739013
87MP0008775_abnormal_heart_ventricle0.69542245
88MP0002928_abnormal_bile_duct0.67380712
89MP0002398_abnormal_bone_marrow0.67053802
90MP0001984_abnormal_olfaction0.65988411
91MP0002837_dystrophic_cardiac_calcinosis0.64931343
92MP0001915_intracranial_hemorrhage0.63213319
93MP0000647_abnormal_sebaceous_gland0.62993765
94MP0005310_abnormal_salivary_gland0.62556354
95MP0001177_atelectasis0.62436805
96MP0001727_abnormal_embryo_implantation0.62347768
97MP0003119_abnormal_digestive_system0.62116508
98MP0005384_cellular_phenotype0.60953533
99MP0005367_renal/urinary_system_phenotyp0.60174173
100MP0000516_abnormal_urinary_system0.60174173

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30351401
2Abnormality of chromosome stability (HP:0003220)4.28416284
3Chromsome breakage (HP:0040012)4.13440745
4Dyschromatopsia (HP:0007641)3.48363461
5Meckel diverticulum (HP:0002245)3.41432480
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.40065192
7Abnormality of the preputium (HP:0100587)3.35731791
8Abnormality of the ileum (HP:0001549)3.29045741
9Nephroblastoma (Wilms tumor) (HP:0002667)3.21749643
10Embryonal renal neoplasm (HP:0011794)3.16616103
11Curly hair (HP:0002212)3.15142765
12T lymphocytopenia (HP:0005403)3.14315547
13Thyroiditis (HP:0100646)3.12393485
14Thyroid carcinoma (HP:0002890)3.08405844
15Papillary thyroid carcinoma (HP:0002895)3.07015436
16Rhabdomyosarcoma (HP:0002859)3.05322495
17Abnormality of the labia minora (HP:0012880)3.02566472
18Abnormality of T cell number (HP:0011839)2.93421466
19IgM deficiency (HP:0002850)2.76440570
20Progressive inability to walk (HP:0002505)2.70703399
21Agnosia (HP:0010524)2.66448774
22Duodenal stenosis (HP:0100867)2.66068633
23Small intestinal stenosis (HP:0012848)2.66068633
24Volvulus (HP:0002580)2.59551381
25Neoplasm of the adrenal cortex (HP:0100641)2.59461103
26Gonadotropin excess (HP:0000837)2.58919636
27Medulloblastoma (HP:0002885)2.58338967
28Ependymoma (HP:0002888)2.55850766
29Breast carcinoma (HP:0003002)2.55435745
30Biliary tract neoplasm (HP:0100574)2.51602588
31Cortical dysplasia (HP:0002539)2.49684419
32Sensory axonal neuropathy (HP:0003390)2.42061486
33B lymphocytopenia (HP:0010976)2.40720454
34Myelodysplasia (HP:0002863)2.38368968
35Clubbing of toes (HP:0100760)2.36692248
36Hematochezia (HP:0002573)2.36481433
37Sloping forehead (HP:0000340)2.28987028
38Abnormality of the duodenum (HP:0002246)2.28058497
39Abnormal lung lobation (HP:0002101)2.27310282
40Combined immunodeficiency (HP:0005387)2.25355335
41Progressive external ophthalmoplegia (HP:0000590)2.24406415
42Glioma (HP:0009733)2.23916908
43Autoimmune hemolytic anemia (HP:0001890)2.21082895
44Cutaneous melanoma (HP:0012056)2.20959586
45Abnormality of B cell number (HP:0010975)2.19677004
46Abnormal biliary tract morphology (HP:0012440)2.19462132
47Eosinophilia (HP:0001880)2.17959355
48Cystic hygroma (HP:0000476)2.16576172
49IgG deficiency (HP:0004315)2.16382253
50Colon cancer (HP:0003003)2.13240684
51Renal cortical cysts (HP:0000803)2.12710728
52Ovarian neoplasm (HP:0100615)2.12071580
53Birth length less than 3rd percentile (HP:0003561)2.07849319
54Asymmetry of the thorax (HP:0001555)2.05195013
55Severe combined immunodeficiency (HP:0004430)2.05097280
56Neoplasm of the small intestine (HP:0100833)2.03432900
57Acute myeloid leukemia (HP:0004808)2.01222239
58Chronic hepatic failure (HP:0100626)2.00640778
59Abnormality of the pons (HP:0007361)1.98726007
60Cafe-au-lait spot (HP:0000957)1.97756886
61Hypoglycemic seizures (HP:0002173)1.96735043
62Cellular immunodeficiency (HP:0005374)1.95913323
63Spastic diplegia (HP:0001264)1.95855818
64Clitoromegaly (HP:0000057)1.94663296
65Abnormality of the astrocytes (HP:0100707)1.93757923
66Astrocytoma (HP:0009592)1.93757923
67Abnormality of DNA repair (HP:0003254)1.93690815
68Prominent metopic ridge (HP:0005487)1.91741538
69Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91483823
70Abnormal auditory evoked potentials (HP:0006958)1.91435429
71Meningioma (HP:0002858)1.90439212
72Neoplasm of striated muscle (HP:0009728)1.90301567
73Hypoplasia of the pons (HP:0012110)1.90113787
74Prostate neoplasm (HP:0100787)1.89892831
75Neoplasm of the colon (HP:0100273)1.89621679
76Abnormality of the septum pellucidum (HP:0007375)1.89344100
77Neoplasm of the adrenal gland (HP:0100631)1.89080522
78Abnormality of eosinophils (HP:0001879)1.88750899
79Arteriovenous malformation (HP:0100026)1.87395587
80Thyroid-stimulating hormone excess (HP:0002925)1.87346148
81Insidious onset (HP:0003587)1.83204018
82Termporal pattern (HP:0011008)1.83204018
83Abnormality of the carotid arteries (HP:0005344)1.82101049
84Conjunctival hamartoma (HP:0100780)1.81018216
85Aplastic anemia (HP:0001915)1.79625867
86Aqueductal stenosis (HP:0002410)1.78207888
87Premature ovarian failure (HP:0008209)1.77886835
88Uterine neoplasm (HP:0010784)1.77871044
89Abnormality of the clitoris (HP:0000056)1.75393730
90Hypoproteinemia (HP:0003075)1.74024491
91Hypoglycemic coma (HP:0001325)1.72802048
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.71287445
93Embryonal neoplasm (HP:0002898)1.70639050
94Female pseudohermaphroditism (HP:0010458)1.68811448
95Hyperinsulinemic hypoglycemia (HP:0000825)1.68236787
96Central scotoma (HP:0000603)1.67459767
97Carpal bone hypoplasia (HP:0001498)1.66048134
98Facial cleft (HP:0002006)1.64818494
99Bone marrow hypocellularity (HP:0005528)1.64114826
100Resting tremor (HP:0002322)1.64068030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.51337449
2FRK3.47815230
3MST43.31176011
4EIF2AK33.25152942
5ZAK3.17847006
6SRPK13.14246673
7ACVR1B2.60748954
8PBK2.34054247
9NUAK12.33564061
10WNK32.30125884
11BUB12.27900942
12TTK2.15673430
13CDC72.07252619
14TSSK62.07041087
15PLK32.02223659
16NLK1.93756297
17BRSK21.93510489
18BCR1.79434738
19MAP3K121.76843665
20PLK41.70196773
21MAP3K101.68178850
22MKNK21.67935381
23MKNK11.64690004
24STK38L1.57124223
25YES11.55086895
26LATS11.51395897
27BMPR1B1.47983577
28TAF11.44212038
29SIK31.40271425
30ERBB31.39225505
31BRD41.37025224
32MARK31.30432927
33PLK11.27205364
34TXK1.22193938
35TNIK1.20849554
36MAP3K41.19633081
37FGFR21.18847232
38PIM11.15464145
39AKT31.07444231
40STK31.05915886
41VRK11.04868233
42EIF2AK11.04579677
43IRAK21.00474085
44WEE10.97299864
45CSNK1G10.96864255
46NEK10.91047991
47PINK10.90139482
48KSR10.88514582
49ATM0.88227513
50NEK60.86206352
51ATR0.82111862
52TEC0.79906331
53IRAK40.78889483
54PLK20.74988813
55ERBB40.74745885
56IRAK10.74287712
57CHEK10.74192688
58RPS6KA40.72644045
59MAP3K140.72493085
60STK40.71916609
61TGFBR10.70815735
62GRK10.69902187
63PASK0.67717541
64SCYL20.66187474
65CHEK20.66167550
66CSNK1G20.64706619
67FER0.62441082
68CDK60.60852457
69STK100.58896112
70CSNK1A1L0.58616582
71DYRK30.58382453
72AURKB0.57951540
73NME10.56129110
74MUSK0.53695193
75CSNK1G30.52236240
76SGK20.51360129
77FGR0.50071949
78EIF2AK20.44898262
79EGFR0.38870652
80BRSK10.38201616
81FGFR30.38147625
82RPS6KB10.37919764
83STK160.36710214
84RPS6KA50.35351500
85PAK30.35000732
86DYRK1A0.34926905
87NEK90.34063294
88CDK70.33871649
89ALK0.33532506
90STK390.32817447
91FGFR10.32452166
92WNK10.31194852
93CSNK2A20.30246699
94PRKCI0.29809780
95CDK20.28389973
96CSNK2A10.28301175
97EPHA30.27580720
98TLK10.26287254
99MAP3K30.25665669
100CDK10.25428562

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98754265
2Mismatch repair_Homo sapiens_hsa034303.95621236
3Non-homologous end-joining_Homo sapiens_hsa034503.94176695
4Fanconi anemia pathway_Homo sapiens_hsa034603.01220561
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.96469070
6DNA replication_Homo sapiens_hsa030302.94554260
7Homologous recombination_Homo sapiens_hsa034402.93468855
8Proteasome_Homo sapiens_hsa030502.90908497
9Basal transcription factors_Homo sapiens_hsa030222.84281501
10RNA transport_Homo sapiens_hsa030132.68913966
11Spliceosome_Homo sapiens_hsa030402.52068928
12Cell cycle_Homo sapiens_hsa041102.50178813
13RNA degradation_Homo sapiens_hsa030182.31281193
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.12387128
15Nucleotide excision repair_Homo sapiens_hsa034202.12246743
16Protein export_Homo sapiens_hsa030602.06572250
17Selenocompound metabolism_Homo sapiens_hsa004501.94308897
18Base excision repair_Homo sapiens_hsa034101.91967797
19RNA polymerase_Homo sapiens_hsa030201.89879076
20Fatty acid elongation_Homo sapiens_hsa000621.72019318
21One carbon pool by folate_Homo sapiens_hsa006701.63663085
22p53 signaling pathway_Homo sapiens_hsa041151.50426350
23mRNA surveillance pathway_Homo sapiens_hsa030151.47832633
24Propanoate metabolism_Homo sapiens_hsa006401.38136414
25Steroid biosynthesis_Homo sapiens_hsa001001.37640199
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.28320124
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27261129
28Systemic lupus erythematosus_Homo sapiens_hsa053221.26731864
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19988802
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17948711
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03037128
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00849245
33Viral carcinogenesis_Homo sapiens_hsa052030.96858864
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95961124
35Oocyte meiosis_Homo sapiens_hsa041140.94900611
36Dorso-ventral axis formation_Homo sapiens_hsa043200.87863727
37Pyrimidine metabolism_Homo sapiens_hsa002400.86073557
38Purine metabolism_Homo sapiens_hsa002300.84822611
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83326221
40Measles_Homo sapiens_hsa051620.82382622
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82333898
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81806655
43MicroRNAs in cancer_Homo sapiens_hsa052060.81539210
44Primary immunodeficiency_Homo sapiens_hsa053400.80456052
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79658108
46Regulation of autophagy_Homo sapiens_hsa041400.76111322
47Alcoholism_Homo sapiens_hsa050340.76009693
48Herpes simplex infection_Homo sapiens_hsa051680.75632558
49Legionellosis_Homo sapiens_hsa051340.71977216
50TGF-beta signaling pathway_Homo sapiens_hsa043500.70663811
51Prostate cancer_Homo sapiens_hsa052150.70659909
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68455669
53Epstein-Barr virus infection_Homo sapiens_hsa051690.67588668
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66312122
55Sphingolipid metabolism_Homo sapiens_hsa006000.63867318
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60023057
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57752389
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56770883
59Hepatitis B_Homo sapiens_hsa051610.56074225
60Melanoma_Homo sapiens_hsa052180.55837645
61N-Glycan biosynthesis_Homo sapiens_hsa005100.52078545
62Phototransduction_Homo sapiens_hsa047440.48944572
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.47386040
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46745160
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46588587
66Peroxisome_Homo sapiens_hsa041460.46468872
67ABC transporters_Homo sapiens_hsa020100.46062938
68mTOR signaling pathway_Homo sapiens_hsa041500.45823671
69Butanoate metabolism_Homo sapiens_hsa006500.45808571
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44514507
71Lysine degradation_Homo sapiens_hsa003100.44114427
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.43782886
73FoxO signaling pathway_Homo sapiens_hsa040680.42188033
74Thyroid cancer_Homo sapiens_hsa052160.41377464
75Type I diabetes mellitus_Homo sapiens_hsa049400.40354504
76Colorectal cancer_Homo sapiens_hsa052100.39152578
77Vitamin B6 metabolism_Homo sapiens_hsa007500.37197289
78Adherens junction_Homo sapiens_hsa045200.35392382
79Small cell lung cancer_Homo sapiens_hsa052220.34852759
80T cell receptor signaling pathway_Homo sapiens_hsa046600.34639644
81Caffeine metabolism_Homo sapiens_hsa002320.34277171
82Apoptosis_Homo sapiens_hsa042100.33192583
83Glutathione metabolism_Homo sapiens_hsa004800.32477833
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31317614
85Graft-versus-host disease_Homo sapiens_hsa053320.30890010
86Wnt signaling pathway_Homo sapiens_hsa043100.30232130
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29474573
88Endometrial cancer_Homo sapiens_hsa052130.28957034
89Antigen processing and presentation_Homo sapiens_hsa046120.28677843
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28183737
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27661009
92Metabolic pathways_Homo sapiens_hsa011000.25624677
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.25489566
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24647941
95Non-small cell lung cancer_Homo sapiens_hsa052230.22381677
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21794890
97HTLV-I infection_Homo sapiens_hsa051660.21421070
98Sulfur metabolism_Homo sapiens_hsa009200.20803999
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20455739
100Influenza A_Homo sapiens_hsa051640.17533793

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