ZNF840P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)9.48777370
2regulation of meiosis I (GO:0060631)8.31843014
3piRNA metabolic process (GO:0034587)8.31438614
4meiotic cell cycle (GO:0051321)8.18366905
5retinal cone cell development (GO:0046549)7.66000645
6multicellular organism reproduction (GO:0032504)7.27538381
7DNA methylation involved in gamete generation (GO:0043046)6.92282693
8positive regulation of histone H3-K4 methylation (GO:0051571)6.88674203
9oocyte development (GO:0048599)6.82239441
10regulation of histone H3-K9 methylation (GO:0051570)6.75085613
11female gamete generation (GO:0007292)6.39909124
12positive regulation of mitotic metaphase/anaphase transition (GO:0045842)6.25906596
13positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)6.25906596
14positive regulation of mitotic sister chromatid separation (GO:1901970)6.25906596
15negative regulation of reproductive process (GO:2000242)6.16307276
16regulation of cell maturation (GO:1903429)6.02159075
17protein kinase C signaling (GO:0070528)5.98920154
18regulation of steroid hormone secretion (GO:2000831)5.86721188
19negative regulation of histone methylation (GO:0031061)5.85774026
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.62995354
21protein localization to kinetochore (GO:0034501)5.58226632
22positive regulation of humoral immune response (GO:0002922)5.49005361
23centriole replication (GO:0007099)5.47692277
24protein localization to chromosome, centromeric region (GO:0071459)5.17575713
25positive regulation of chromosome segregation (GO:0051984)5.16610274
26gene silencing by RNA (GO:0031047)5.10285152
27positive regulation of gastrulation (GO:2000543)5.06638985
28mitotic chromosome condensation (GO:0007076)4.99300803
29mitotic metaphase plate congression (GO:0007080)4.90251946
30establishment of chromosome localization (GO:0051303)4.87577082
31reproduction (GO:0000003)4.80421122
32glycine transport (GO:0015816)4.79291050
33primitive streak formation (GO:0090009)4.53797353
34positive regulation of histone methylation (GO:0031062)4.37671012
35regulation of steroid hormone biosynthetic process (GO:0090030)4.23310037
36citrulline biosynthetic process (GO:0019240)4.23154891
37regulation of meiosis (GO:0040020)4.21208230
38synaptonemal complex assembly (GO:0007130)4.20460092
39synapsis (GO:0007129)4.14202526
40protein localization to chromosome (GO:0034502)4.10011714
41binding of sperm to zona pellucida (GO:0007339)4.06365776
42fertilization (GO:0009566)4.03750577
43regulation of histone H3-K4 methylation (GO:0051569)3.98676836
44metaphase plate congression (GO:0051310)3.96738947
45DNA methylation (GO:0006306)3.93975998
46DNA alkylation (GO:0006305)3.93975998
47attachment of spindle microtubules to kinetochore (GO:0008608)3.86296765
48chromosome organization involved in meiosis (GO:0070192)3.85981114
49regulation of histone methylation (GO:0031060)3.79408313
50male meiosis (GO:0007140)3.75223869
51phosphorelay signal transduction system (GO:0000160)3.74755044
52positive regulation of reproductive process (GO:2000243)3.74104153
53centriole assembly (GO:0098534)3.73259083
54relaxation of smooth muscle (GO:0044557)3.72594789
55synaptonemal complex organization (GO:0070193)3.71795381
56negative regulation of hormone biosynthetic process (GO:0032353)3.71345607
57negative regulation of cAMP-mediated signaling (GO:0043951)3.69856006
58male meiosis I (GO:0007141)3.65690587
59oogenesis (GO:0048477)3.64745069
60regulation of spindle organization (GO:0090224)3.60251461
61single fertilization (GO:0007338)3.54355574
62regulation of reproductive process (GO:2000241)3.53389995
63regulation of chromatin silencing (GO:0031935)3.51599927
64negative regulation of hormone metabolic process (GO:0032351)3.49007480
65neuron fate determination (GO:0048664)3.46651424
66regulation of calcium ion-dependent exocytosis (GO:0017158)3.46021161
67regulation of meiotic cell cycle (GO:0051445)3.45308358
68gene silencing (GO:0016458)3.45059995
69negative regulation of histone modification (GO:0031057)3.44797458
70CENP-A containing nucleosome assembly (GO:0034080)3.41982207
71somite rostral/caudal axis specification (GO:0032525)3.41062143
72meiotic nuclear division (GO:0007126)3.39830743
73regulation of double-strand break repair via homologous recombination (GO:0010569)3.37994145
74nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.36626680
75labyrinthine layer development (GO:0060711)3.35094247
76regulation of spindle checkpoint (GO:0090231)3.34795514
77L-amino acid import (GO:0043092)3.33883600
78regulation of corticosteroid hormone secretion (GO:2000846)3.33239113
79negative regulation of execution phase of apoptosis (GO:1900118)3.32854343
80meiotic cell cycle process (GO:1903046)3.29741063
81DNA damage induced protein phosphorylation (GO:0006975)3.26008158
82genitalia morphogenesis (GO:0035112)3.17997934
83regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.14489880
84sperm-egg recognition (GO:0035036)3.14372529
85DNA replication-dependent nucleosome assembly (GO:0006335)3.12752848
86DNA replication-dependent nucleosome organization (GO:0034723)3.12752848
87interkinetic nuclear migration (GO:0022027)3.12656042
88regulation of phospholipid biosynthetic process (GO:0071071)3.11645731
89phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.11201858
90regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.10654773
91translesion synthesis (GO:0019985)3.09814061
92regulation of hypersensitivity (GO:0002883)3.09545314
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09539858
94regulation of RNA export from nucleus (GO:0046831)3.09035013
95chromatin remodeling at centromere (GO:0031055)3.07941006
96negative regulation of chromatin modification (GO:1903309)3.06227419
97centrosome duplication (GO:0051298)3.06205265
98N-terminal protein amino acid acetylation (GO:0006474)3.05985269
99regulation of DNA methylation (GO:0044030)10.7117617
100regulation of female gonad development (GO:2000194)10.4531149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.95714617
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.29626746
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.17696992
4E2F7_22180533_ChIP-Seq_HELA_Human3.26078678
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.77102825
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.77102825
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.77102825
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.74299813
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.72361352
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71384898
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58427963
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54867805
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05764969
14EZH2_22144423_ChIP-Seq_EOC_Human14.8036748
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.93381263
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.90648241
17GBX2_23144817_ChIP-Seq_PC3_Human1.90378671
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88428968
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.74573737
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.65321813
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63180339
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60755553
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52706100
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50103272
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45975327
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43050259
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.36425817
28AR_21909140_ChIP-Seq_LNCAP_Human1.33711158
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25802075
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25126680
31CBP_20019798_ChIP-Seq_JUKART_Human1.25126680
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.24327684
33TCF4_23295773_ChIP-Seq_U87_Human1.21693211
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20886263
35IRF1_19129219_ChIP-ChIP_H3396_Human1.19963928
36PRDM14_20953172_ChIP-Seq_ESCs_Human1.16820928
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10718966
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07992619
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07016928
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07016928
41AR_25329375_ChIP-Seq_VCAP_Human1.06395482
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05528604
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03198141
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.02637940
45SMAD4_21799915_ChIP-Seq_A2780_Human1.02347605
46LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01736586
47CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01211632
48SMAD4_21741376_ChIP-Seq_EPCs_Human0.99791500
49STAT3_23295773_ChIP-Seq_U87_Human0.96969530
50RUNX2_22187159_ChIP-Seq_PCA_Human0.96651707
51EWS_26573619_Chip-Seq_HEK293_Human0.96145026
52GF1_26923725_Chip-Seq_HPCs_Mouse0.94246376
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93779480
54HTT_18923047_ChIP-ChIP_STHdh_Human0.93762629
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92111461
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91760779
57CBP_21632823_ChIP-Seq_H3396_Human0.90757499
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88355073
59NANOG_20526341_ChIP-Seq_ESCs_Human0.87693340
60P300_19829295_ChIP-Seq_ESCs_Human0.87424851
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86915707
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84782679
63AHR_22903824_ChIP-Seq_MCF-7_Human0.83596486
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83311062
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82564099
66PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81894311
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81602565
68LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81478152
69TAL1_26923725_Chip-Seq_HPCs_Mouse0.80962971
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80957095
71SMAD3_21741376_ChIP-Seq_EPCs_Human0.80071535
72TP53_16413492_ChIP-PET_HCT116_Human0.79481965
73FOXH1_21741376_ChIP-Seq_EPCs_Human0.78815022
74GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77012181
75NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76542024
76SMRT_27268052_Chip-Seq_Bcells_Human0.73908338
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.73305186
78SALL4_22934838_ChIP-ChIP_CD34+_Human0.72820285
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68829885
80ZNF217_24962896_ChIP-Seq_MCF-7_Human0.68548202
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.66842370
82TP53_22573176_ChIP-Seq_HFKS_Human0.66351343
83KLF4_19829295_ChIP-Seq_ESCs_Human0.65782283
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.64506745
85SOX2_21211035_ChIP-Seq_LN229_Gbm0.64310537
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.63792462
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.63735054
88BMI1_23680149_ChIP-Seq_NPCS_Mouse0.63236577
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.62604813
90CREB1_15753290_ChIP-ChIP_HEK293T_Human0.62484148
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.62104528
92CDX2_22108803_ChIP-Seq_LS180_Human0.61869888
93DROSHA_22980978_ChIP-Seq_HELA_Human0.61859451
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.61819687
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.61036881
96REST_21632747_ChIP-Seq_MESCs_Mouse0.60391645
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.60276361
98ZNF274_21170338_ChIP-Seq_K562_Hela0.58428617
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.58344449
100RNF2_27304074_Chip-Seq_NSC_Mouse0.58309304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.52213331
2MP0008877_abnormal_DNA_methylation4.80903792
3MP0006292_abnormal_olfactory_placode4.69290104
4MP0008789_abnormal_olfactory_epithelium4.56913476
5MP0005499_abnormal_olfactory_system3.99333371
6MP0005394_taste/olfaction_phenotype3.99333371
7MP0002139_abnormal_hepatobiliary_system3.63806410
8MP0005395_other_phenotype3.34098393
9MP0003890_abnormal_embryonic-extraembry3.20319633
10MP0002138_abnormal_hepatobiliary_system2.93346126
11MP0008057_abnormal_DNA_replication2.87895520
12MP0003693_abnormal_embryo_hatching2.74005354
13MP0010030_abnormal_orbit_morphology2.59539911
14MP0003699_abnormal_female_reproductive2.57229772
15MP0010234_abnormal_vibrissa_follicle2.43835784
16MP0005360_urolithiasis2.43016045
17MP0002234_abnormal_pharynx_morphology2.40685282
18MP0003183_abnormal_peptide_metabolism2.38246609
19MP0001929_abnormal_gametogenesis2.21632872
20MP0003879_abnormal_hair_cell2.12478668
21MP0008058_abnormal_DNA_repair2.07526341
22MP0002210_abnormal_sex_determination2.04979682
23MP0003077_abnormal_cell_cycle2.01183678
24MP0010094_abnormal_chromosome_stability1.99276227
25MP0005410_abnormal_fertilization1.76255127
26MP0000653_abnormal_sex_gland1.68755720
27MP0003950_abnormal_plasma_membrane1.67986178
28MP0002161_abnormal_fertility/fecundity1.67703394
29MP0010307_abnormal_tumor_latency1.58838111
30MP0003121_genomic_imprinting1.58230813
31MP0000566_synostosis1.54916536
32MP0003111_abnormal_nucleus_morphology1.54677845
33MP0001984_abnormal_olfaction1.40813743
34MP0001293_anophthalmia1.39198451
35MP0001119_abnormal_female_reproductive1.35888692
36MP0002160_abnormal_reproductive_system1.34590834
37MP0001730_embryonic_growth_arrest1.32554867
38MP0003252_abnormal_bile_duct1.28906521
39MP0001145_abnormal_male_reproductive1.26115181
40MP0008932_abnormal_embryonic_tissue1.22111099
41MP0005647_abnormal_sex_gland1.17555410
42MP0000762_abnormal_tongue_morphology1.16350903
43MP0002233_abnormal_nose_morphology1.15632935
44MP0005646_abnormal_pituitary_gland1.15499926
45MP0000631_abnormal_neuroendocrine_gland1.14818690
46MP0009840_abnormal_foam_cell1.09577494
47MP0003698_abnormal_male_reproductive1.09357464
48MP0005389_reproductive_system_phenotype1.08060048
49MP0010368_abnormal_lymphatic_system1.07285863
50MP0000427_abnormal_hair_cycle1.03200057
51MP0003119_abnormal_digestive_system0.93858711
52MP0005085_abnormal_gallbladder_physiolo0.93100944
53MP0001672_abnormal_embryogenesis/_devel0.89419625
54MP0005380_embryogenesis_phenotype0.89419625
55MP0010678_abnormal_skin_adnexa0.88304288
56MP0002272_abnormal_nervous_system0.87731532
57MP0001666_abnormal_nutrient_absorption0.83036118
58MP0003868_abnormal_feces_composition0.82394644
59MP0005551_abnormal_eye_electrophysiolog0.82300813
60MP0000350_abnormal_cell_proliferation0.82020659
61MP0004142_abnormal_muscle_tone0.78477368
62MP0001986_abnormal_taste_sensitivity0.77865733
63MP0001664_abnormal_digestion0.77820026
64MP0003136_yellow_coat_color0.71571367
65MP0001324_abnormal_eye_pigmentation0.69361062
66MP0006276_abnormal_autonomic_nervous0.66416879
67MP0000049_abnormal_middle_ear0.65566122
68MP0002396_abnormal_hematopoietic_system0.60269667
69MP0002928_abnormal_bile_duct0.56276138
70MP0002084_abnormal_developmental_patter0.55921239
71MP0004043_abnormal_pH_regulation0.55325736
72MP0004957_abnormal_blastocyst_morpholog0.54760098
73MP0002089_abnormal_postnatal_growth/wei0.54190055
74MP0001963_abnormal_hearing_physiology0.51321910
75MP0002796_impaired_skin_barrier0.50438092
76MP0000678_abnormal_parathyroid_gland0.48393239
77MP0001919_abnormal_reproductive_system0.48366057
78MP0001502_abnormal_circadian_rhythm0.47825520
79MP0000015_abnormal_ear_pigmentation0.47254378
80MP0002090_abnormal_vision0.46535994
81MP0005075_abnormal_melanosome_morpholog0.45176365
82MP0002127_abnormal_cardiovascular_syste0.44341311
83MP0003935_abnormal_craniofacial_develop0.43130477
84MP0005501_abnormal_skin_physiology0.42022106
85MP0003941_abnormal_skin_development0.41952911
86MP0002638_abnormal_pupillary_reflex0.41683914
87MP0000428_abnormal_craniofacial_morphol0.41556029
88MP0003755_abnormal_palate_morphology0.41344477
89MP0003959_abnormal_lean_body0.40187509
90MP0002085_abnormal_embryonic_tissue0.38903284
91MP0005503_abnormal_tendon_morphology0.38322484
92MP0000377_abnormal_hair_follicle0.37137721
93MP0005319_abnormal_enzyme/_coenzyme0.35870596
94MP0002751_abnormal_autonomic_nervous0.35194615
95MP0005076_abnormal_cell_differentiation0.35173453
96MP0002873_normal_phenotype0.34809851
97MP0002169_no_abnormal_phenotype0.34264990
98MP0002019_abnormal_tumor_incidence0.33989468
99MP0001697_abnormal_embryo_size0.33865328
100MP0003984_embryonic_growth_retardation0.32704795

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)6.43040690
2Facial hemangioma (HP:0000329)5.54529239
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.46091943
4Abnormality of abdominal situs (HP:0011620)5.21330224
5Abdominal situs inversus (HP:0003363)5.21330224
6Abnormal gallbladder physiology (HP:0012438)5.01360520
7Cholecystitis (HP:0001082)5.01360520
8Aplasia/Hypoplasia of the fovea (HP:0008060)4.84229073
9Hypoplasia of the fovea (HP:0007750)4.84229073
10Osteomalacia (HP:0002749)4.74521508
11Impulsivity (HP:0100710)4.73521462
12Lip pit (HP:0100267)4.68186614
13Oligodactyly (hands) (HP:0001180)4.64633192
14Anterior segment dysgenesis (HP:0007700)4.51644048
15Septo-optic dysplasia (HP:0100842)4.26028237
16Chromsome breakage (HP:0040012)4.24752354
17Papillary thyroid carcinoma (HP:0002895)4.20474982
18Abnormality of the fovea (HP:0000493)4.12005252
19Hypophosphatemic rickets (HP:0004912)4.07671567
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99624525
21Male infertility (HP:0003251)3.79611236
22Median cleft lip (HP:0000161)3.78441094
23Azoospermia (HP:0000027)3.69038753
24Abnormality of the labia minora (HP:0012880)3.65640263
25Infertility (HP:0000789)3.62689404
26Absent septum pellucidum (HP:0001331)3.47031064
27Capillary hemangiomas (HP:0005306)3.35915571
28Enlarged penis (HP:0000040)3.34741113
29Oligodactyly (HP:0012165)3.32143030
30Short tibia (HP:0005736)3.28298657
31Wrist flexion contracture (HP:0001239)3.20969670
32Hypokinesia (HP:0002375)3.16774445
33Apathy (HP:0000741)3.16749670
34Gonadotropin excess (HP:0000837)3.16313861
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.14082288
36Aplasia/Hypoplasia of the macula (HP:0008059)3.06153492
37Diminished motivation (HP:0000745)3.03448650
38Abnormality of the septum pellucidum (HP:0007375)2.97708088
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.94299917
40Fair hair (HP:0002286)2.86304350
41Aplasia/Hypoplasia affecting the retina (HP:0008061)2.80506813
42Malnutrition (HP:0004395)2.79400977
43Abnormal spermatogenesis (HP:0008669)2.78845332
44Truncal obesity (HP:0001956)2.70178270
45Premature ovarian failure (HP:0008209)2.66646771
46Spinal cord compression (HP:0002176)2.58573548
47Lower limb hyperreflexia (HP:0002395)2.56795309
48Stillbirth (HP:0003826)2.50873955
49Posterior subcapsular cataract (HP:0007787)2.48490545
50Intrahepatic cholestasis (HP:0001406)2.45800616
51Metaphyseal irregularity (HP:0003025)2.44930926
52Urethral obstruction (HP:0000796)2.41583214
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.37747817
54Bile duct proliferation (HP:0001408)2.37727038
55Abnormal biliary tract physiology (HP:0012439)2.37727038
56Thyroid carcinoma (HP:0002890)2.36557779
57Nephroblastoma (Wilms tumor) (HP:0002667)2.31626090
58Dysdiadochokinesis (HP:0002075)2.31346501
59Ankle contracture (HP:0006466)2.30971712
60Congenital sensorineural hearing impairment (HP:0008527)2.30141936
61Maternal diabetes (HP:0009800)2.28644747
62Abnormality of chromosome stability (HP:0003220)2.27627011
63Heterotopia (HP:0002282)2.27331239
64Striae distensae (HP:0001065)2.25136159
65Abnormality of the phalanges of the hallux (HP:0010057)2.23487952
66Abnormal ciliary motility (HP:0012262)2.22752466
67Aplasia of the musculature (HP:0100854)2.22563020
68Embryonal renal neoplasm (HP:0011794)2.18657685
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.18406900
70Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.16208579
71Skin pits (HP:0100276)2.10074741
72Proximal tubulopathy (HP:0000114)2.08214345
73Abnormal lung lobation (HP:0002101)2.05389766
74Conjunctival telangiectasia (HP:0000524)2.03566879
75Generalized hypopigmentation of hair (HP:0011358)2.03191371
76Abnormality of the preputium (HP:0100587)2.00626170
77Hypergonadotropic hypogonadism (HP:0000815)1.99949690
78Hip contracture (HP:0003273)1.99637215
79Subcapsular cataract (HP:0000523)1.99493251
80Meckel diverticulum (HP:0002245)1.97777686
81Anhidrosis (HP:0000970)1.97311034
82Myokymia (HP:0002411)1.93471621
83Loss of speech (HP:0002371)1.93246932
84Duodenal stenosis (HP:0100867)1.93174484
85Small intestinal stenosis (HP:0012848)1.93174484
86Abnormality of chromosome segregation (HP:0002916)1.92531770
87Bicornuate uterus (HP:0000813)1.91941726
88Microglossia (HP:0000171)1.91908875
89Bundle branch block (HP:0011710)1.90733972
90Sensory axonal neuropathy (HP:0003390)1.90156423
91Shallow orbits (HP:0000586)1.87553021
92Abnormality of the anterior chamber (HP:0000593)1.87280005
93Abnormality of the ileum (HP:0001549)1.85841901
94Muscle stiffness (HP:0003552)1.84878602
95Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81409834
96Neoplasm of the oral cavity (HP:0100649)1.81408034
97Abnormal respiratory motile cilium physiology (HP:0012261)1.81196213
98Broad alveolar ridges (HP:0000187)1.80756091
99Cone-rod dystrophy (HP:0000548)1.80392423
100Optic nerve hypoplasia (HP:0000609)1.79543204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.14299918
2MAP3K135.50796100
3ARAF5.46034634
4NEK63.46554318
5TAOK33.35558235
6TTK3.15958363
7CDK93.10001624
8BRAF2.97915647
9CDK122.95838657
10STK242.84639517
11AURKA2.47293391
12MET2.39415511
13MOS2.38533104
14CDC72.21806505
15NTRK22.12164187
16RAF11.87286555
17PRKCI1.87025024
18KSR21.79610250
19TNIK1.73258387
20EIF2AK31.51287387
21CDK71.42820637
22PLK11.41486732
23MELK1.38371139
24STK31.26930819
25KSR11.20913553
26TRIM281.20256778
27MST41.19038866
28NUAK11.16187075
29NEK91.14674537
30MAP3K80.93195757
31CHEK10.89965443
32ZAK0.88076455
33NEK20.87893425
34BUB10.87381237
35BRSK10.85730244
36MARK30.83603830
37TNK20.83546509
38STK390.83393328
39PIM10.83118069
40DMPK0.79951054
41CDK20.78501457
42CSNK1G10.76951032
43PLK30.76911252
44TIE10.75113047
45PTK20.74297234
46AURKB0.73643113
47CHEK20.72322277
48ATM0.68367422
49WNK10.68005709
50BMPR1B0.67873445
51TGFBR10.67177395
52CSNK1D0.65163980
53PRKG10.60506817
54CDK10.58651157
55MAPKAPK30.55361912
56CDK80.55052219
57MTOR0.52976064
58PRKCZ0.52485775
59MAPK130.51661036
60CAMK1D0.49991267
61CSNK1G30.49798825
62BRD40.48849644
63CHUK0.47103733
64PAK10.46926183
65ATR0.45487460
66CSNK1E0.45033471
67BRSK20.44532677
68EEF2K0.43731746
69VRK10.42013651
70PKN10.40995701
71CAMK2A0.40602330
72NTRK30.37925329
73PRKACB0.37475848
74CDK50.36922293
75ACVR1B0.36120951
76PRKACA0.34190692
77CSNK1A1L0.30798133
78TYRO30.30295499
79MAP3K40.29726455
80PBK0.29276736
81CSNK1G20.28871674
82GSK3B0.28852410
83MAPK10.28743164
84LRRK20.26411673
85OXSR10.26398674
86MAP3K50.25033485
87PLK40.20830022
88CDK190.20808718
89PDK10.20468520
90EPHA40.20073754
91MAPK100.18849767
92CAMK1G0.18408165
93TRPM70.18233140
94SRPK10.15953667
95AKT20.13992273
96LMTK20.12907665
97EGFR0.12028785
98PRKAA20.10303188
99PRKAA10.09315861
100LATS10.08835419

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.10661237
2Cell cycle_Homo sapiens_hsa041104.57356508
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.85235748
4Ovarian steroidogenesis_Homo sapiens_hsa049133.73102812
5Mismatch repair_Homo sapiens_hsa034303.50459303
6Oocyte meiosis_Homo sapiens_hsa041143.41282296
7Caffeine metabolism_Homo sapiens_hsa002323.29580067
8RNA degradation_Homo sapiens_hsa030182.92981941
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.58082587
10Dorso-ventral axis formation_Homo sapiens_hsa043202.56333776
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.53934402
12Homologous recombination_Homo sapiens_hsa034402.52641639
13Base excision repair_Homo sapiens_hsa034102.41284685
14Fanconi anemia pathway_Homo sapiens_hsa034602.30651316
15Nucleotide excision repair_Homo sapiens_hsa034202.29940464
16Cysteine and methionine metabolism_Homo sapiens_hsa002702.14154968
17Circadian rhythm_Homo sapiens_hsa047102.05203558
18DNA replication_Homo sapiens_hsa030302.03246824
19Olfactory transduction_Homo sapiens_hsa047401.87557676
20RNA transport_Homo sapiens_hsa030131.80775461
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74872678
22p53 signaling pathway_Homo sapiens_hsa041151.73729634
23Gap junction_Homo sapiens_hsa045401.64758550
24Folate biosynthesis_Homo sapiens_hsa007901.57113744
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44577919
26Phototransduction_Homo sapiens_hsa047441.42203215
27Thyroid cancer_Homo sapiens_hsa052161.34381684
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27924194
29Inositol phosphate metabolism_Homo sapiens_hsa005621.21587726
30ABC transporters_Homo sapiens_hsa020101.15715665
31Nicotine addiction_Homo sapiens_hsa050331.13123989
32mRNA surveillance pathway_Homo sapiens_hsa030151.01543036
33Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99642894
34SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96312693
35Bile secretion_Homo sapiens_hsa049760.94157950
36Morphine addiction_Homo sapiens_hsa050320.91138142
37Synaptic vesicle cycle_Homo sapiens_hsa047210.89394592
38GABAergic synapse_Homo sapiens_hsa047270.88185809
39TGF-beta signaling pathway_Homo sapiens_hsa043500.80998573
40mTOR signaling pathway_Homo sapiens_hsa041500.78916435
41RNA polymerase_Homo sapiens_hsa030200.72248875
42FoxO signaling pathway_Homo sapiens_hsa040680.67590643
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60076494
44Taste transduction_Homo sapiens_hsa047420.57378130
45Adherens junction_Homo sapiens_hsa045200.55706115
46Vitamin digestion and absorption_Homo sapiens_hsa049770.54887889
47Long-term depression_Homo sapiens_hsa047300.54263864
48MicroRNAs in cancer_Homo sapiens_hsa052060.53442685
49Purine metabolism_Homo sapiens_hsa002300.52959507
50Serotonergic synapse_Homo sapiens_hsa047260.51194058
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51156133
52Non-homologous end-joining_Homo sapiens_hsa034500.50062003
53Fatty acid elongation_Homo sapiens_hsa000620.45241392
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45160443
55Herpes simplex infection_Homo sapiens_hsa051680.39259804
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35870812
57Viral carcinogenesis_Homo sapiens_hsa052030.35543103
58Hippo signaling pathway_Homo sapiens_hsa043900.35402074
59Small cell lung cancer_Homo sapiens_hsa052220.32780657
60HTLV-I infection_Homo sapiens_hsa051660.32341393
61Notch signaling pathway_Homo sapiens_hsa043300.30930594
62Ras signaling pathway_Homo sapiens_hsa040140.30445361
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30341300
64ErbB signaling pathway_Homo sapiens_hsa040120.29641627
65Wnt signaling pathway_Homo sapiens_hsa043100.29226906
66cAMP signaling pathway_Homo sapiens_hsa040240.28285344
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28095421
68Endometrial cancer_Homo sapiens_hsa052130.26557133
69Phagosome_Homo sapiens_hsa041450.24287115
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24111963
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23672552
72Regulation of autophagy_Homo sapiens_hsa041400.21572162
73Oxytocin signaling pathway_Homo sapiens_hsa049210.21415878
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21057451
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19706233
76Protein digestion and absorption_Homo sapiens_hsa049740.19641148
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19178359
78Lysine degradation_Homo sapiens_hsa003100.16626597
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16149669
80Renal cell carcinoma_Homo sapiens_hsa052110.15440364
81Cholinergic synapse_Homo sapiens_hsa047250.14758786
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.13127995
83Circadian entrainment_Homo sapiens_hsa047130.12522123
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.11549018
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.10973670
86Propanoate metabolism_Homo sapiens_hsa006400.09972184
87Glutamatergic synapse_Homo sapiens_hsa047240.09225011
88Long-term potentiation_Homo sapiens_hsa047200.09007299
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.08018113
90Huntingtons disease_Homo sapiens_hsa050160.07855812
91Colorectal cancer_Homo sapiens_hsa052100.07756929
92Arginine and proline metabolism_Homo sapiens_hsa003300.07558285
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06591561
94Dopaminergic synapse_Homo sapiens_hsa047280.06000491
95Tight junction_Homo sapiens_hsa045300.05954812
96Rap1 signaling pathway_Homo sapiens_hsa040150.05548858
97HIF-1 signaling pathway_Homo sapiens_hsa040660.05517771
98Pathways in cancer_Homo sapiens_hsa052000.04782103
99Melanogenesis_Homo sapiens_hsa049160.04767264
100Arginine biosynthesis_Homo sapiens_hsa002200.04530731

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