ZNF839

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.04711693
2behavioral response to nicotine (GO:0035095)4.78758817
3DNA methylation involved in gamete generation (GO:0043046)4.19431631
4fucose catabolic process (GO:0019317)3.73104101
5L-fucose metabolic process (GO:0042354)3.73104101
6L-fucose catabolic process (GO:0042355)3.73104101
7synapsis (GO:0007129)3.67525993
8cilium or flagellum-dependent cell motility (GO:0001539)3.67474852
9indolalkylamine metabolic process (GO:0006586)3.60713562
10peptidyl-histidine modification (GO:0018202)3.60470897
11male meiosis (GO:0007140)3.53549054
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50708577
13tryptophan catabolic process (GO:0006569)3.49803164
14indole-containing compound catabolic process (GO:0042436)3.49803164
15indolalkylamine catabolic process (GO:0046218)3.49803164
16tryptophan metabolic process (GO:0006568)3.28778940
17ubiquinone biosynthetic process (GO:0006744)3.21181122
18axoneme assembly (GO:0035082)3.19371239
19neural tube formation (GO:0001841)3.18529090
20male meiosis I (GO:0007141)3.15728566
21regulation of cilium movement (GO:0003352)3.12732931
22DNA deamination (GO:0045006)3.11814205
23detection of light stimulus involved in sensory perception (GO:0050962)3.09228474
24detection of light stimulus involved in visual perception (GO:0050908)3.09228474
25protein polyglutamylation (GO:0018095)3.05732092
26cellular ketone body metabolic process (GO:0046950)3.04165624
27epithelial cilium movement (GO:0003351)3.03883211
28DNA double-strand break processing (GO:0000729)3.01475861
29establishment of protein localization to Golgi (GO:0072600)2.98956018
30regulation of hippo signaling (GO:0035330)2.98245420
31negative regulation of cAMP-mediated signaling (GO:0043951)2.97836112
32histone H3-K9 methylation (GO:0051567)2.97465483
33photoreceptor cell maintenance (GO:0045494)2.96082344
34preassembly of GPI anchor in ER membrane (GO:0016254)2.92795925
35cilium movement (GO:0003341)2.92365022
36rRNA catabolic process (GO:0016075)2.91720962
37replication fork processing (GO:0031297)2.90714365
38multicellular organism reproduction (GO:0032504)2.90601572
39reciprocal meiotic recombination (GO:0007131)2.87581508
40reciprocal DNA recombination (GO:0035825)2.87581508
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82910536
42ubiquinone metabolic process (GO:0006743)2.82658418
43sulfation (GO:0051923)2.81136912
44DNA methylation or demethylation (GO:0044728)2.79283713
45gene silencing by RNA (GO:0031047)2.76849125
46DNA demethylation (GO:0080111)2.76796197
47regulation of meiosis I (GO:0060631)2.76565091
48DNA alkylation (GO:0006305)2.74751831
49DNA methylation (GO:0006306)2.74751831
50mast cell activation involved in immune response (GO:0002279)2.72206521
51mast cell degranulation (GO:0043303)2.72206521
52DNA modification (GO:0006304)2.70893813
53double-strand break repair via homologous recombination (GO:0000724)2.69830341
54protein K63-linked deubiquitination (GO:0070536)2.68270462
55recombinational repair (GO:0000725)2.67627126
56interkinetic nuclear migration (GO:0022027)2.67315763
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67146460
58regulation of gamma-delta T cell differentiation (GO:0045586)2.65652127
59negative regulation of mast cell activation (GO:0033004)2.65621083
60ketone body metabolic process (GO:1902224)2.65577148
61protein targeting to Golgi (GO:0000042)2.64206869
62cilium organization (GO:0044782)2.63905955
63protein K11-linked deubiquitination (GO:0035871)2.63581396
64intraciliary transport (GO:0042073)2.62923093
65metallo-sulfur cluster assembly (GO:0031163)2.62741180
66iron-sulfur cluster assembly (GO:0016226)2.62741180
67quinone biosynthetic process (GO:1901663)2.61394687
68cornea development in camera-type eye (GO:0061303)2.61057904
69resolution of meiotic recombination intermediates (GO:0000712)2.60765042
70motile cilium assembly (GO:0044458)2.60729819
71adenosine metabolic process (GO:0046085)2.60633339
72protein localization to Golgi apparatus (GO:0034067)2.60572463
73inositol phosphate catabolic process (GO:0071545)2.58739004
74cilium assembly (GO:0042384)2.56557825
75tRNA modification (GO:0006400)2.55321562
76regulation of action potential (GO:0098900)2.55162589
77organic cation transport (GO:0015695)2.54314418
78meiotic chromosome segregation (GO:0045132)2.53447035
79positive regulation of granulocyte differentiation (GO:0030854)2.51648517
80negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51504339
81retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49698112
82snRNA transcription (GO:0009301)2.48756111
83polyol catabolic process (GO:0046174)2.46609511
84chromosome organization involved in meiosis (GO:0070192)2.46331177
85protein localization to cilium (GO:0061512)2.45954125
86response to pheromone (GO:0019236)2.44129860
87mannosylation (GO:0097502)2.43405978
88negative regulation of telomere maintenance (GO:0032205)2.42609699
89indole-containing compound metabolic process (GO:0042430)2.42261678
90histone H4-K8 acetylation (GO:0043982)2.40071440
91histone H4-K5 acetylation (GO:0043981)2.40071440
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39371636
93sperm motility (GO:0030317)2.39086125
94positive regulation of defense response to virus by host (GO:0002230)2.37288095
95lysosome localization (GO:0032418)2.37115731
96methionine biosynthetic process (GO:0009086)2.36772343
97purinergic nucleotide receptor signaling pathway (GO:0035590)2.36728476
98phosphatidylethanolamine biosynthetic process (GO:0006646)2.35695956
99histone H3-K9 modification (GO:0061647)2.34228829
100spermatid development (GO:0007286)2.34013719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.95685291
2ZNF274_21170338_ChIP-Seq_K562_Hela4.46952031
3IGF1R_20145208_ChIP-Seq_DFB_Human3.90832975
4VDR_22108803_ChIP-Seq_LS180_Human3.43510663
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.64782917
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45976821
7ER_23166858_ChIP-Seq_MCF-7_Human2.36567872
8GBX2_23144817_ChIP-Seq_PC3_Human2.35276451
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.29670772
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15535304
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04079366
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87817788
13EWS_26573619_Chip-Seq_HEK293_Human1.84924140
14EZH2_22144423_ChIP-Seq_EOC_Human1.83213148
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78762829
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77895768
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77832049
18IRF1_19129219_ChIP-ChIP_H3396_Human1.75991558
19FUS_26573619_Chip-Seq_HEK293_Human1.72680343
20AR_21572438_ChIP-Seq_LNCaP_Human1.69608623
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.65178970
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.61554766
23* VDR_23849224_ChIP-Seq_CD4+_Human1.57470606
24ERA_21632823_ChIP-Seq_H3396_Human1.55525337
25TP53_22573176_ChIP-Seq_HFKS_Human1.54455968
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51683327
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47118411
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47038411
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45342667
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41442183
31CBP_20019798_ChIP-Seq_JUKART_Human1.41442183
32GATA3_26560356_Chip-Seq_TH2_Human1.41102379
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.40737370
34FOXP3_21729870_ChIP-Seq_TREG_Human1.40579684
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.40428827
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40330187
37CIITA_25753668_ChIP-Seq_RAJI_Human1.38158194
38HOXB7_26014856_ChIP-Seq_BT474_Human1.37502757
39BCAT_22108803_ChIP-Seq_LS180_Human1.36096418
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34837814
41P300_19829295_ChIP-Seq_ESCs_Human1.34561240
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.34187643
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31656195
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31656195
45STAT3_23295773_ChIP-Seq_U87_Human1.31090223
46MYC_18940864_ChIP-ChIP_HL60_Human1.27054344
47NCOR_22424771_ChIP-Seq_293T_Human1.26591405
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25917951
49OCT4_20526341_ChIP-Seq_ESCs_Human1.25676001
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24806733
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24772298
52NANOG_20526341_ChIP-Seq_ESCs_Human1.24688481
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.23654102
54TCF4_23295773_ChIP-Seq_U87_Human1.20303247
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20062681
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.20062681
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19922437
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19411508
59AR_20517297_ChIP-Seq_VCAP_Human1.17990162
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17335187
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16419387
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.16253720
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15203442
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13005783
65RAC3_21632823_ChIP-Seq_H3396_Human1.12857816
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11441892
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11005526
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10871608
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10681180
70TAF15_26573619_Chip-Seq_HEK293_Human1.09672627
71AR_25329375_ChIP-Seq_VCAP_Human1.09393413
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.06463674
73RUNX2_22187159_ChIP-Seq_PCA_Human1.06359607
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05635028
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05431450
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04842577
77GATA3_27048872_Chip-Seq_THYMUS_Human1.04719598
78KDM5A_27292631_Chip-Seq_BREAST_Human1.04450993
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02445550
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01595182
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.01308142
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.01024367
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99480627
84MYC_19829295_ChIP-Seq_ESCs_Human0.99413572
85NANOG_19829295_ChIP-Seq_ESCs_Human0.98369673
86SOX2_19829295_ChIP-Seq_ESCs_Human0.98369673
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.97552489
88TCF4_22108803_ChIP-Seq_LS180_Human0.97369958
89FLI1_21867929_ChIP-Seq_TH2_Mouse0.97244810
90MYB_26560356_Chip-Seq_TH2_Human0.96790322
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95154672
92RUNX_20019798_ChIP-Seq_JUKART_Human0.93384092
93GATA3_26560356_Chip-Seq_TH1_Human0.89820951
94SMAD4_21799915_ChIP-Seq_A2780_Human0.88992492
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.86475761
96GATA1_22025678_ChIP-Seq_K562_Human0.86427698
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86119770
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86036649
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84524373
100P300_27268052_Chip-Seq_Bcells_Human0.84363161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.88677401
2MP0001986_abnormal_taste_sensitivity2.62231526
3MP0000569_abnormal_digit_pigmentation2.40600137
4MP0005075_abnormal_melanosome_morpholog2.32688590
5MP0008058_abnormal_DNA_repair2.32204575
6MP0008995_early_reproductive_senescence2.31684137
7MP0003763_abnormal_thymus_physiology2.15848345
8MP0005645_abnormal_hypothalamus_physiol2.10942726
9MP0005174_abnormal_tail_pigmentation2.10055909
10MP0004381_abnormal_hair_follicle2.02963311
11MP0005551_abnormal_eye_electrophysiolog2.00875967
12MP0001968_abnormal_touch/_nociception2.00606589
13MP0002138_abnormal_hepatobiliary_system1.95625944
14MP0003646_muscle_fatigue1.93730731
15MP0000015_abnormal_ear_pigmentation1.93051643
16MP0002160_abnormal_reproductive_system1.87986299
17MP0002837_dystrophic_cardiac_calcinosis1.84433794
18MP0000427_abnormal_hair_cycle1.81657650
19MP0002638_abnormal_pupillary_reflex1.81161350
20MP0003136_yellow_coat_color1.80291615
21MP0005646_abnormal_pituitary_gland1.69664866
22MP0002102_abnormal_ear_morphology1.68394323
23MP0008789_abnormal_olfactory_epithelium1.54633046
24MP0006292_abnormal_olfactory_placode1.50658932
25MP0008872_abnormal_physiological_respon1.47971782
26MP0005389_reproductive_system_phenotype1.46815300
27MP0001929_abnormal_gametogenesis1.46106871
28MP0003698_abnormal_male_reproductive1.45252131
29MP0008057_abnormal_DNA_replication1.44218272
30MP0002132_abnormal_respiratory_system1.43437648
31MP0005410_abnormal_fertilization1.41751314
32MP0006072_abnormal_retinal_apoptosis1.38687061
33MP0003787_abnormal_imprinting1.36998187
34MP0004145_abnormal_muscle_electrophysio1.36294114
35MP0000631_abnormal_neuroendocrine_gland1.34266773
36MP0010386_abnormal_urinary_bladder1.31723296
37MP0001873_stomach_inflammation1.27611332
38MP0004043_abnormal_pH_regulation1.27602775
39MP0005499_abnormal_olfactory_system1.26436654
40MP0005394_taste/olfaction_phenotype1.26436654
41MP0003786_premature_aging1.25241506
42MP0005253_abnormal_eye_physiology1.25054121
43MP0000372_irregular_coat_pigmentation1.24093045
44MP0002210_abnormal_sex_determination1.22842402
45MP0006036_abnormal_mitochondrial_physio1.22780642
46MP0003195_calcinosis1.21868135
47MP0001764_abnormal_homeostasis1.18586935
48MP0002736_abnormal_nociception_after1.17940925
49MP0001984_abnormal_olfaction1.17825688
50MP0002876_abnormal_thyroid_physiology1.17163849
51MP0001501_abnormal_sleep_pattern1.16143954
52MP0001145_abnormal_male_reproductive1.14939632
53MP0010094_abnormal_chromosome_stability1.13414500
54MP0000653_abnormal_sex_gland1.11634987
55MP0001485_abnormal_pinna_reflex1.08604824
56MP0002095_abnormal_skin_pigmentation1.07262098
57MP0006276_abnormal_autonomic_nervous1.05795065
58MP0001919_abnormal_reproductive_system1.04650556
59MP0006035_abnormal_mitochondrial_morpho1.01125202
60MP0001800_abnormal_humoral_immune1.00486945
61MP0004133_heterotaxia0.97135785
62MP0000703_abnormal_thymus_morphology0.96512297
63MP0008961_abnormal_basal_metabolism0.94479850
64MP0008875_abnormal_xenobiotic_pharmacok0.94131888
65MP0000383_abnormal_hair_follicle0.93808626
66MP0002396_abnormal_hematopoietic_system0.91679383
67MP0002653_abnormal_ependyma_morphology0.90684644
68MP0005266_abnormal_metabolism0.88248804
69MP0001324_abnormal_eye_pigmentation0.88017929
70MP0004084_abnormal_cardiac_muscle0.87443941
71MP0002735_abnormal_chemical_nociception0.84359575
72MP0005171_absent_coat_pigmentation0.82450183
73MP0005220_abnormal_exocrine_pancreas0.81312533
74MP0000689_abnormal_spleen_morphology0.81043408
75MP0002254_reproductive_system_inflammat0.80951638
76MP0001188_hyperpigmentation0.80921919
77MP0009745_abnormal_behavioral_response0.79785823
78MP0003806_abnormal_nucleotide_metabolis0.79342414
79MP0002234_abnormal_pharynx_morphology0.78326436
80MP0002693_abnormal_pancreas_physiology0.77723754
81MP0001664_abnormal_digestion0.77690104
82MP0002127_abnormal_cardiovascular_syste0.76058156
83MP0002163_abnormal_gland_morphology0.75703485
84MP0003878_abnormal_ear_physiology0.75438849
85MP0005377_hearing/vestibular/ear_phenot0.75438849
86MP0004484_altered_response_of0.74407797
87MP0000230_abnormal_systemic_arterial0.72562686
88MP0001486_abnormal_startle_reflex0.72009189
89MP0002009_preneoplasia0.71450359
90MP0000749_muscle_degeneration0.69998624
91MP0000013_abnormal_adipose_tissue0.69485014
92MP0002277_abnormal_respiratory_mucosa0.69466701
93MP0003943_abnormal_hepatobiliary_system0.69247214
94MP0002722_abnormal_immune_system0.69157185
95MP0001119_abnormal_female_reproductive0.68858342
96MP0002928_abnormal_bile_duct0.68766967
97MP0001661_extended_life_span0.68665153
98MP0009697_abnormal_copulation0.66882398
99MP0009046_muscle_twitch0.66613426
100MP0002723_abnormal_immune_serum0.66247079

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.46620532
2Type II lissencephaly (HP:0007260)3.85612400
3Molar tooth sign on MRI (HP:0002419)3.77321951
4Abnormality of midbrain morphology (HP:0002418)3.77321951
5True hermaphroditism (HP:0010459)3.74222162
6Nephronophthisis (HP:0000090)3.54678580
7Chronic hepatic failure (HP:0100626)3.49004862
8Pancreatic fibrosis (HP:0100732)3.44251413
9Abnormality of the renal cortex (HP:0011035)3.18412412
10Cerebellar dysplasia (HP:0007033)3.16189665
11Congenital stationary night blindness (HP:0007642)3.15341828
12Abnormality of the renal medulla (HP:0100957)3.06277432
13Attenuation of retinal blood vessels (HP:0007843)3.00247153
14Panhypogammaglobulinemia (HP:0003139)2.93645133
15Hypoplasia of the pons (HP:0012110)2.86068338
16Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84438902
17Abolished electroretinogram (ERG) (HP:0000550)2.77319816
18Retinal dysplasia (HP:0007973)2.74675083
19Abnormal rod and cone electroretinograms (HP:0008323)2.73578593
20Stomach cancer (HP:0012126)2.72433181
21Cystic liver disease (HP:0006706)2.71736060
22Protruding tongue (HP:0010808)2.69058147
23Abnormality of the pons (HP:0007361)2.63507801
24Medial flaring of the eyebrow (HP:0010747)2.57990213
25Clumsiness (HP:0002312)2.50858129
26Abnormality of DNA repair (HP:0003254)2.48183302
27Abnormal respiratory epithelium morphology (HP:0012253)2.43894882
28Abnormal respiratory motile cilium morphology (HP:0005938)2.43894882
29Abnormal drinking behavior (HP:0030082)2.42467503
30Polydipsia (HP:0001959)2.42467503
31Abnormality of B cell number (HP:0010975)2.40518224
32Renal cortical cysts (HP:0000803)2.31937141
33Tubular atrophy (HP:0000092)2.31684892
34Abnormal biliary tract physiology (HP:0012439)2.29635325
35Bile duct proliferation (HP:0001408)2.29635325
36Anencephaly (HP:0002323)2.27309713
37Male pseudohermaphroditism (HP:0000037)2.27135562
38Abnormal ciliary motility (HP:0012262)2.23580572
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.21656173
40Lissencephaly (HP:0001339)2.21527225
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.16595357
42Ketosis (HP:0001946)2.16418500
43Inability to walk (HP:0002540)2.15733598
44Congenital hepatic fibrosis (HP:0002612)2.12901182
45Gaze-evoked nystagmus (HP:0000640)2.09930594
46Abnormality of the columella (HP:0009929)2.04749518
47Chromsome breakage (HP:0040012)2.04503722
48Stomatitis (HP:0010280)2.04341992
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03608264
50Acute lymphatic leukemia (HP:0006721)2.03283977
51Reduced antithrombin III activity (HP:0001976)2.02129627
52Abnormality of the ileum (HP:0001549)2.00658138
53Hyperglycinemia (HP:0002154)2.00396652
54Sclerocornea (HP:0000647)1.96386574
55Concave nail (HP:0001598)1.95107511
56Hypoplastic iliac wings (HP:0002866)1.94982630
57Abnormality of alanine metabolism (HP:0010916)1.93930054
58Hyperalaninemia (HP:0003348)1.93930054
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93930054
60Nephrogenic diabetes insipidus (HP:0009806)1.93137180
61Dynein arm defect of respiratory motile cilia (HP:0012255)1.92608454
62Absent/shortened dynein arms (HP:0200106)1.92608454
63Aplasia/Hypoplasia of the spleen (HP:0010451)1.91016945
64Pendular nystagmus (HP:0012043)1.90501001
65Small hand (HP:0200055)1.89736512
66Abnormal protein glycosylation (HP:0012346)1.89610755
67Abnormal glycosylation (HP:0012345)1.89610755
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89610755
69Abnormal protein N-linked glycosylation (HP:0012347)1.89610755
70Abnormal respiratory motile cilium physiology (HP:0012261)1.89571048
71B lymphocytopenia (HP:0010976)1.87955739
72Sloping forehead (HP:0000340)1.87254369
73Meckel diverticulum (HP:0002245)1.86804874
74Asplenia (HP:0001746)1.85719323
75Postaxial foot polydactyly (HP:0001830)1.85653046
76Occipital encephalocele (HP:0002085)1.85358523
77Bony spicule pigmentary retinopathy (HP:0007737)1.85251788
78Clubbing of toes (HP:0100760)1.84888156
79Genetic anticipation (HP:0003743)1.84811999
80Thyroiditis (HP:0100646)1.84315463
81Hyperventilation (HP:0002883)1.83185489
82Abnormality of the renal collecting system (HP:0004742)1.81930185
83IgG deficiency (HP:0004315)1.79472750
84Absent thumb (HP:0009777)1.78554442
85Polyuria (HP:0000103)1.78293471
86Progressive inability to walk (HP:0002505)1.76325308
87Severe muscular hypotonia (HP:0006829)1.75942639
88Neoplasm of the adrenal cortex (HP:0100641)1.73694420
89Furrowed tongue (HP:0000221)1.72428451
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.72130614
91Duplicated collecting system (HP:0000081)1.72034272
92Hyperglycinuria (HP:0003108)1.71697675
93Large for gestational age (HP:0001520)1.70855403
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70447002
95Eosinophilia (HP:0001880)1.70245905
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.69085199
97Congenital primary aphakia (HP:0007707)1.67804120
98Hypoproteinemia (HP:0003075)1.65114412
99Abnormality of the preputium (HP:0100587)1.65086347
100Aplasia/Hypoplasia involving the musculature (HP:0001460)1.64134600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.36143219
2PINK13.40706124
3ZAK3.39676925
4MARK32.75800819
5TLK12.49900956
6NUAK12.26908556
7BMPR1B2.26766671
8INSRR2.24737181
9ADRBK22.24574141
10TAOK32.18572520
11TNK22.17713995
12MAP4K22.15026677
13TRIM282.08691341
14OBSCN2.08569648
15LATS11.91199121
16TXK1.90130671
17EIF2AK31.62428945
18MAP3K41.62255562
19GRK11.55063512
20NLK1.41914081
21MAPK131.40787602
22MAP2K71.33654867
23ACVR1B1.33264175
24WNK41.26588356
25WNK31.26224713
26MAP2K61.26087618
27MAP4K11.12877594
28STK38L1.10070573
29BTK1.09504044
30MAP3K71.05254995
31TEC1.03338077
32MUSK1.02806410
33CSNK1G11.01651053
34CSNK1A1L0.99052921
35GRK60.98677070
36ITK0.97880471
37MAP2K20.97549238
38PHKG20.95553928
39PHKG10.95553928
40FGFR20.94259619
41PRKCQ0.93940358
42NME10.93674710
43CSNK1G30.91313665
44PTK2B0.90713127
45RPS6KA50.89282871
46IKBKE0.85947394
47CDK30.85826997
48FES0.80247715
49IKBKB0.79164002
50IRAK20.78724176
51MAPK120.76838937
52IRAK10.75905065
53CASK0.74539890
54OXSR10.73917875
55CAMKK20.71627414
56AKT30.69832721
57PRKCI0.69658330
58SYK0.68049737
59STK110.67459584
60MAPKAPK30.61741713
61CSNK1G20.61405473
62MKNK20.61043470
63MAP2K30.58846791
64CAMK40.58818830
65STK390.58790980
66KIT0.58415065
67ATR0.58363763
68MAP2K40.58044594
69DYRK30.57752452
70VRK10.57565476
71NEK20.56355536
72CDK190.56196608
73STK380.56087056
74BRSK20.55474909
75CHUK0.55198672
76RPS6KA60.54863711
77EEF2K0.53244488
78SIK20.52257458
79FLT30.51885532
80ADRBK10.51179911
81HCK0.50399887
82PRKAA20.48217231
83PRKAA10.47849928
84PKN20.47645770
85PIM10.47619851
86CAMK10.46520119
87MAPK150.46142169
88PAK30.45335324
89ATM0.45086813
90CHEK20.43543324
91RPS6KB10.42893944
92BCKDK0.42314003
93LCK0.39766006
94PRKD20.39208567
95CSNK1D0.37974239
96LYN0.36985189
97DYRK20.34802048
98CDK80.33932882
99PRKCE0.33876789
100MAPK110.33750044

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.04065953
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.73935945
3Butanoate metabolism_Homo sapiens_hsa006502.65391058
4Linoleic acid metabolism_Homo sapiens_hsa005912.50204871
5Fanconi anemia pathway_Homo sapiens_hsa034602.48064865
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42792706
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42303325
8Primary immunodeficiency_Homo sapiens_hsa053402.35057473
9Basal transcription factors_Homo sapiens_hsa030222.32253525
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29759654
11Homologous recombination_Homo sapiens_hsa034402.28934278
12Nitrogen metabolism_Homo sapiens_hsa009102.23152502
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17856472
14Selenocompound metabolism_Homo sapiens_hsa004502.06949080
15Regulation of autophagy_Homo sapiens_hsa041401.97622487
16Olfactory transduction_Homo sapiens_hsa047401.96128925
17ABC transporters_Homo sapiens_hsa020101.87924339
18One carbon pool by folate_Homo sapiens_hsa006701.62073464
19Ether lipid metabolism_Homo sapiens_hsa005651.56894489
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50290894
21Taste transduction_Homo sapiens_hsa047421.49216815
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48782158
23Propanoate metabolism_Homo sapiens_hsa006401.40164945
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38828143
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38052414
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37554749
27Caffeine metabolism_Homo sapiens_hsa002321.28220357
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26995446
29RNA degradation_Homo sapiens_hsa030181.25055897
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.20107884
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.18468525
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16498217
33Arachidonic acid metabolism_Homo sapiens_hsa005901.14848647
34RNA polymerase_Homo sapiens_hsa030201.13038385
35Tryptophan metabolism_Homo sapiens_hsa003801.11497086
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.09182884
37Chemical carcinogenesis_Homo sapiens_hsa052041.08325170
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07637030
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01169582
40Non-homologous end-joining_Homo sapiens_hsa034500.99996337
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99914121
42Peroxisome_Homo sapiens_hsa041460.97175117
43T cell receptor signaling pathway_Homo sapiens_hsa046600.96154772
44Calcium signaling pathway_Homo sapiens_hsa040200.95837125
45Lysine degradation_Homo sapiens_hsa003100.88116215
46Circadian rhythm_Homo sapiens_hsa047100.87437995
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.87046150
48Purine metabolism_Homo sapiens_hsa002300.86630187
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81864098
50Base excision repair_Homo sapiens_hsa034100.81303076
51Dorso-ventral axis formation_Homo sapiens_hsa043200.80080555
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.77301049
53Systemic lupus erythematosus_Homo sapiens_hsa053220.75658661
54Pyrimidine metabolism_Homo sapiens_hsa002400.75393115
55Circadian entrainment_Homo sapiens_hsa047130.74744733
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73262023
57Salivary secretion_Homo sapiens_hsa049700.71438748
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71413317
59Oxytocin signaling pathway_Homo sapiens_hsa049210.70976287
60Asthma_Homo sapiens_hsa053100.69573436
61Nucleotide excision repair_Homo sapiens_hsa034200.66687167
62mTOR signaling pathway_Homo sapiens_hsa041500.66508894
63Nicotine addiction_Homo sapiens_hsa050330.65353014
64Ovarian steroidogenesis_Homo sapiens_hsa049130.65217861
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64692636
66beta-Alanine metabolism_Homo sapiens_hsa004100.63304671
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62256629
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60906133
69Inositol phosphate metabolism_Homo sapiens_hsa005620.58005555
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57807488
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55539090
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55232324
73Glycerolipid metabolism_Homo sapiens_hsa005610.53606226
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53020190
75RNA transport_Homo sapiens_hsa030130.52819250
76Alcoholism_Homo sapiens_hsa050340.51672322
77Type I diabetes mellitus_Homo sapiens_hsa049400.49077454
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48485039
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48234968
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47956512
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.45094223
82Platelet activation_Homo sapiens_hsa046110.44657861
83Graft-versus-host disease_Homo sapiens_hsa053320.43568438
84Metabolic pathways_Homo sapiens_hsa011000.42450720
85Autoimmune thyroid disease_Homo sapiens_hsa053200.42373227
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42084424
87Retinol metabolism_Homo sapiens_hsa008300.41638825
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41111546
89Morphine addiction_Homo sapiens_hsa050320.40872747
90Insulin resistance_Homo sapiens_hsa049310.40436751
91Allograft rejection_Homo sapiens_hsa053300.40270398
92Serotonergic synapse_Homo sapiens_hsa047260.40252496
93Hematopoietic cell lineage_Homo sapiens_hsa046400.39812933
94Choline metabolism in cancer_Homo sapiens_hsa052310.39451226
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38966094
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37955445
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35422781
98Glucagon signaling pathway_Homo sapiens_hsa049220.35162792
99Sphingolipid metabolism_Homo sapiens_hsa006000.35152663
100Herpes simplex infection_Homo sapiens_hsa051680.34870209

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