ZNF836

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.24978487
2water-soluble vitamin biosynthetic process (GO:0042364)3.93370012
3negative regulation of mast cell activation (GO:0033004)3.87279286
4DNA deamination (GO:0045006)3.69024726
5somite development (GO:0061053)3.63048924
6startle response (GO:0001964)3.52791894
7platelet dense granule organization (GO:0060155)3.52426775
8reflex (GO:0060004)3.47411949
9positive regulation of oligodendrocyte differentiation (GO:0048714)3.45887581
10neural tube formation (GO:0001841)3.40946976
11protein polyglutamylation (GO:0018095)3.40128675
12gamma-aminobutyric acid transport (GO:0015812)3.37355970
13axoneme assembly (GO:0035082)3.36128679
14indolalkylamine metabolic process (GO:0006586)3.35587964
15presynaptic membrane assembly (GO:0097105)3.35286127
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.34325506
17response to pheromone (GO:0019236)3.33255408
18kidney morphogenesis (GO:0060993)3.30274082
19pyrimidine nucleobase catabolic process (GO:0006208)3.27494811
20righting reflex (GO:0060013)3.24683215
21nonmotile primary cilium assembly (GO:0035058)3.24374894
22adaptation of signaling pathway (GO:0023058)3.10699280
23regulation of action potential (GO:0098900)3.08016492
24nucleobase catabolic process (GO:0046113)3.07645268
25negative regulation of telomere maintenance (GO:0032205)3.06235980
26regulation of glomerulus development (GO:0090192)3.03448853
27negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.03359854
28auditory receptor cell stereocilium organization (GO:0060088)3.02075744
29presynaptic membrane organization (GO:0097090)3.00110217
30positive regulation of glomerulus development (GO:0090193)2.99942018
31tryptophan metabolic process (GO:0006568)2.98347451
32protein localization to cilium (GO:0061512)2.97428890
33photoreceptor cell maintenance (GO:0045494)2.95988421
34inner ear receptor stereocilium organization (GO:0060122)2.93618329
35tryptophan catabolic process (GO:0006569)2.89968762
36indole-containing compound catabolic process (GO:0042436)2.89968762
37indolalkylamine catabolic process (GO:0046218)2.89968762
38activated T cell proliferation (GO:0050798)2.89835072
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87467887
40protein complex biogenesis (GO:0070271)2.87432660
41inositol phosphate catabolic process (GO:0071545)2.87122834
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86896516
43limb bud formation (GO:0060174)2.86879008
44cell proliferation in forebrain (GO:0021846)2.86787856
45sulfation (GO:0051923)2.84343384
46regulation of telomere maintenance (GO:0032204)2.83557426
47serotonin metabolic process (GO:0042428)2.82974690
48indole-containing compound metabolic process (GO:0042430)2.81203981
49positive regulation of cardiac muscle cell differentiation (GO:2000727)2.78375048
50preassembly of GPI anchor in ER membrane (GO:0016254)2.77658466
51primary amino compound metabolic process (GO:1901160)2.77095860
52neuronal action potential (GO:0019228)2.77017874
53positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.76069547
54regulation of memory T cell differentiation (GO:0043380)2.75524432
55fucose catabolic process (GO:0019317)2.75373641
56L-fucose metabolic process (GO:0042354)2.75373641
57L-fucose catabolic process (GO:0042355)2.75373641
58detection of light stimulus involved in visual perception (GO:0050908)2.72748749
59detection of light stimulus involved in sensory perception (GO:0050962)2.72748749
60acrosome reaction (GO:0007340)2.71487708
61protein K11-linked deubiquitination (GO:0035871)2.71459931
62dopamine transport (GO:0015872)2.70965484
63negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70471762
64embryonic epithelial tube formation (GO:0001838)2.69057958
65GPI anchor metabolic process (GO:0006505)2.68655596
66piRNA metabolic process (GO:0034587)2.67637165
67postsynaptic membrane organization (GO:0001941)2.64076308
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62919555
69regulation of neurotransmitter uptake (GO:0051580)2.62514304
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.58381492
71NADH dehydrogenase complex assembly (GO:0010257)2.58381492
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58381492
73purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58228849
743-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58228849
75transmission of nerve impulse (GO:0019226)2.58226323
76cornea development in camera-type eye (GO:0061303)2.57314982
77cellular response to ATP (GO:0071318)2.57294253
78prostate gland growth (GO:0060736)2.54974641
79neuronal action potential propagation (GO:0019227)2.54216937
80cell wall macromolecule metabolic process (GO:0044036)2.53787709
81positive regulation of meiosis (GO:0045836)2.53726811
82regulation of DNA endoreduplication (GO:0032875)2.52615399
83mitochondrial respiratory chain complex assembly (GO:0033108)2.51449076
84epithelial tube formation (GO:0072175)2.49836168
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46730684
86cilium morphogenesis (GO:0060271)2.44778281
87establishment of protein localization to Golgi (GO:0072600)2.44152513
88dentate gyrus development (GO:0021542)2.42488156
89thyroid hormone metabolic process (GO:0042403)2.42472553
90RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.42296576
91phosphatidylethanolamine metabolic process (GO:0046337)2.42275668
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41522128
93DNA methylation involved in gamete generation (GO:0043046)2.41055940
94regulation of collateral sprouting (GO:0048670)2.40490770
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40039104
96regulation of meiosis I (GO:0060631)2.38284824
97phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38233083
98inositol phosphate dephosphorylation (GO:0046855)2.38233083
99synapsis (GO:0007129)2.37997017
100negative regulation of systemic arterial blood pressure (GO:0003085)2.37777716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.34638045
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12604130
3ZNF274_21170338_ChIP-Seq_K562_Hela3.01701210
4EZH2_22144423_ChIP-Seq_EOC_Human2.89420734
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72596466
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62949660
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57491973
8VDR_22108803_ChIP-Seq_LS180_Human2.54256847
9IGF1R_20145208_ChIP-Seq_DFB_Human2.51021305
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38321117
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36816770
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29140763
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25315616
14FUS_26573619_Chip-Seq_HEK293_Human2.18215600
15EWS_26573619_Chip-Seq_HEK293_Human2.17944717
16P300_19829295_ChIP-Seq_ESCs_Human2.13332534
17TAF15_26573619_Chip-Seq_HEK293_Human2.12105102
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.04616599
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.01770858
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00107540
21IRF1_19129219_ChIP-ChIP_H3396_Human1.96752623
22ER_23166858_ChIP-Seq_MCF-7_Human1.92571837
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85145723
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84072794
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73238297
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70265746
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69508824
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69309772
29SMAD4_21799915_ChIP-Seq_A2780_Human1.65883650
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57912766
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.56867221
32STAT3_23295773_ChIP-Seq_U87_Human1.56771069
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55821278
34AR_25329375_ChIP-Seq_VCAP_Human1.54594767
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54574145
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53530536
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.50120091
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49104716
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46970285
40TCF4_23295773_ChIP-Seq_U87_Human1.46678903
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46379349
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45877716
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.45532565
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43347250
45RNF2_27304074_Chip-Seq_NSC_Mouse1.42361461
46BCAT_22108803_ChIP-Seq_LS180_Human1.41414059
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.39770160
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38561039
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38066522
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37361859
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37361859
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35693095
53CBP_20019798_ChIP-Seq_JUKART_Human1.35693095
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.32774979
55REST_21632747_ChIP-Seq_MESCs_Mouse1.31869948
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31533350
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29078418
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28076615
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27561715
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.26355879
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25547643
62RUNX2_22187159_ChIP-Seq_PCA_Human1.23637656
63TCF4_22108803_ChIP-Seq_LS180_Human1.22946711
64TP53_22573176_ChIP-Seq_HFKS_Human1.22569041
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.21243129
66NANOG_19829295_ChIP-Seq_ESCs_Human1.20894674
67SOX2_19829295_ChIP-Seq_ESCs_Human1.20894674
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.19443539
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18324513
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18036066
71P53_22387025_ChIP-Seq_ESCs_Mouse1.17362807
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16175772
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16114790
74* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14181738
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.13735721
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13396976
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.11626243
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11009414
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10824117
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10230194
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.09652977
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09227818
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.09227818
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08839410
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.07154470
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.06769633
87CDX2_22108803_ChIP-Seq_LS180_Human1.05885428
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.05310273
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05105097
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.03933711
91JUN_21703547_ChIP-Seq_K562_Human1.01675687
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.01110153
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.00751828
94AR_21572438_ChIP-Seq_LNCaP_Human1.00483479
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.00091890
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99733744
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99563269
98P300_18555785_Chip-Seq_ESCs_Mouse0.99114186
99KDM2B_26808549_Chip-Seq_REH_Human0.99112197
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97999359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.72062051
2MP0002102_abnormal_ear_morphology3.70337567
3MP0002837_dystrophic_cardiac_calcinosis3.34563799
4MP0008877_abnormal_DNA_methylation3.16150139
5MP0003787_abnormal_imprinting3.10781440
6MP0005646_abnormal_pituitary_gland2.75605041
7MP0003195_calcinosis2.70534978
8MP0000372_irregular_coat_pigmentation2.66618853
9MP0003646_muscle_fatigue2.26586566
10MP0001968_abnormal_touch/_nociception2.17618974
11MP0006072_abnormal_retinal_apoptosis2.02406830
12MP0005551_abnormal_eye_electrophysiolog1.90244361
13MP0002736_abnormal_nociception_after1.87994875
14MP0006292_abnormal_olfactory_placode1.85161415
15MP0002638_abnormal_pupillary_reflex1.84540448
16MP0002138_abnormal_hepatobiliary_system1.82847005
17MP0004885_abnormal_endolymph1.82203118
18MP0001986_abnormal_taste_sensitivity1.75682092
19MP0005645_abnormal_hypothalamus_physiol1.70790748
20MP0003011_delayed_dark_adaptation1.70352314
21MP0006276_abnormal_autonomic_nervous1.69563617
22MP0009046_muscle_twitch1.64853863
23MP0004142_abnormal_muscle_tone1.63656369
24MP0002272_abnormal_nervous_system1.63256781
25MP0000631_abnormal_neuroendocrine_gland1.63138825
26MP0005379_endocrine/exocrine_gland_phen1.62881437
27MP0009745_abnormal_behavioral_response1.62417844
28MP0008872_abnormal_physiological_respon1.60765239
29MP0005253_abnormal_eye_physiology1.55754771
30MP0004147_increased_porphyrin_level1.52576767
31MP0001486_abnormal_startle_reflex1.48785936
32MP0008995_early_reproductive_senescence1.48052506
33MP0005084_abnormal_gallbladder_morpholo1.44174111
34MP0003283_abnormal_digestive_organ1.42466485
35MP0005389_reproductive_system_phenotype1.39719618
36MP0002163_abnormal_gland_morphology1.39210802
37MP0001919_abnormal_reproductive_system1.38633454
38MP0002876_abnormal_thyroid_physiology1.37022725
39MP0003121_genomic_imprinting1.34934213
40MP0002653_abnormal_ependyma_morphology1.33988171
41MP0001485_abnormal_pinna_reflex1.28841207
42MP0000516_abnormal_urinary_system1.26658847
43MP0005367_renal/urinary_system_phenotyp1.26658847
44MP0004742_abnormal_vestibular_system1.23347710
45MP0001984_abnormal_olfaction1.21965872
46MP0005075_abnormal_melanosome_morpholog1.21150788
47MP0003724_increased_susceptibility_to1.19820669
48MP0002064_seizures1.16996093
49MP0003635_abnormal_synaptic_transmissio1.16387819
50MP0002928_abnormal_bile_duct1.16382205
51MP0002733_abnormal_thermal_nociception1.15814421
52MP0000569_abnormal_digit_pigmentation1.15726982
53MP0002734_abnormal_mechanical_nocicepti1.15005395
54MP0001970_abnormal_pain_threshold1.12919868
55MP0001764_abnormal_homeostasis1.11571702
56MP0003122_maternal_imprinting1.11484408
57MP0002735_abnormal_chemical_nociception1.09280442
58MP0004133_heterotaxia1.05989223
59MP0002751_abnormal_autonomic_nervous1.05751770
60MP0010386_abnormal_urinary_bladder1.02735206
61MP0002572_abnormal_emotion/affect_behav1.01695661
62MP0002557_abnormal_social/conspecific_i1.01160795
63MP0003567_abnormal_fetal_cardiomyocyte1.00857690
64MP0000383_abnormal_hair_follicle0.99173103
65MP0004270_analgesia0.99159489
66MP0001529_abnormal_vocalization0.99132817
67MP0002160_abnormal_reproductive_system0.97306621
68MP0002063_abnormal_learning/memory/cond0.96112177
69MP0002909_abnormal_adrenal_gland0.95597745
70MP0002277_abnormal_respiratory_mucosa0.95556599
71MP0002254_reproductive_system_inflammat0.94996654
72MP0004145_abnormal_muscle_electrophysio0.94971621
73MP0001188_hyperpigmentation0.94849301
74MP0003119_abnormal_digestive_system0.94432460
75MP0000778_abnormal_nervous_system0.94413731
76MP0008789_abnormal_olfactory_epithelium0.93999299
77MP0001501_abnormal_sleep_pattern0.92982226
78MP0002067_abnormal_sensory_capabilities0.91827802
79MP0001963_abnormal_hearing_physiology0.91167021
80MP0005408_hypopigmentation0.91004636
81MP0000427_abnormal_hair_cycle0.88823849
82MP0005423_abnormal_somatic_nervous0.87243206
83MP0000026_abnormal_inner_ear0.87238073
84MP0005195_abnormal_posterior_eye0.87232542
85MP0005670_abnormal_white_adipose0.85506879
86MP0002938_white_spotting0.83318965
87MP0002184_abnormal_innervation0.83202766
88MP0000049_abnormal_middle_ear0.82461996
89MP0001440_abnormal_grooming_behavior0.82264043
90MP0003938_abnormal_ear_development0.81735803
91MP0005410_abnormal_fertilization0.81466149
92MP0005386_behavior/neurological_phenoty0.80529843
93MP0004924_abnormal_behavior0.80529843
94MP0002693_abnormal_pancreas_physiology0.80459793
95MP0005171_absent_coat_pigmentation0.80146730
96MP0005174_abnormal_tail_pigmentation0.80141795
97MP0005187_abnormal_penis_morphology0.79688873
98MP0001324_abnormal_eye_pigmentation0.79163967
99MP0002752_abnormal_somatic_nervous0.78899226
100MP0003937_abnormal_limbs/digits/tail_de0.78543184

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.64141860
2Pancreatic cysts (HP:0001737)3.63738327
3Congenital sensorineural hearing impairment (HP:0008527)3.49963733
4True hermaphroditism (HP:0010459)3.34714358
5Nephronophthisis (HP:0000090)3.22839571
6Abnormality of midbrain morphology (HP:0002418)3.18544350
7Molar tooth sign on MRI (HP:0002419)3.18544350
8Pancreatic fibrosis (HP:0100732)3.07275508
9Medial flaring of the eyebrow (HP:0010747)3.00683457
10Hyperventilation (HP:0002883)3.00276122
11Methylmalonic acidemia (HP:0002912)2.95754008
12Abnormality of the renal cortex (HP:0011035)2.93766695
13Gaze-evoked nystagmus (HP:0000640)2.82595237
14Abolished electroretinogram (ERG) (HP:0000550)2.76196902
15Abnormality of the renal medulla (HP:0100957)2.69734810
16Agitation (HP:0000713)2.69204386
17Hemiparesis (HP:0001269)2.58061247
18Renal cortical cysts (HP:0000803)2.57312653
19Genetic anticipation (HP:0003743)2.45609212
20Abnormality of the proximal phalanges of the hand (HP:0009834)2.41441881
21Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.40660468
22Short 1st metacarpal (HP:0010034)2.40660468
23Methylmalonic aciduria (HP:0012120)2.39570549
24Stomach cancer (HP:0012126)2.39505107
25Gait imbalance (HP:0002141)2.38499417
26Abnormal rod and cone electroretinograms (HP:0008323)2.36578438
27Progressive cerebellar ataxia (HP:0002073)2.35533418
28Chronic hepatic failure (HP:0100626)2.34324641
29Nephrogenic diabetes insipidus (HP:0009806)2.33267705
30Type II lissencephaly (HP:0007260)2.30991273
31Congenital primary aphakia (HP:0007707)2.30921598
32Attenuation of retinal blood vessels (HP:0007843)2.28803940
33Male pseudohermaphroditism (HP:0000037)2.21238866
34Aplasia/hypoplasia of the uterus (HP:0008684)2.19987405
35Hyperglycinemia (HP:0002154)2.19772410
363-Methylglutaconic aciduria (HP:0003535)2.19540879
37Symphalangism affecting the phalanges of the hand (HP:0009773)2.18701186
38Abnormality of the 1st metacarpal (HP:0010009)2.14937341
39Ketosis (HP:0001946)2.14357315
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.07867320
41Hypoplasia of the fovea (HP:0007750)2.07867320
42Stenosis of the external auditory canal (HP:0000402)2.07853184
43Keratoconus (HP:0000563)2.07116819
44Increased corneal curvature (HP:0100692)2.07116819
45Pendular nystagmus (HP:0012043)2.03837136
46Absent speech (HP:0001344)2.02983112
47Hypoplasia of the uterus (HP:0000013)2.00458878
48Abnormality of the labia minora (HP:0012880)1.99682704
49Lissencephaly (HP:0001339)1.98636221
50Humeroradial synostosis (HP:0003041)1.98413822
51Synostosis involving the elbow (HP:0003938)1.98413822
52Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.97618264
53Broad-based gait (HP:0002136)1.96427399
54Genital tract atresia (HP:0001827)1.95867476
55Cystic liver disease (HP:0006706)1.94843548
56Vaginal atresia (HP:0000148)1.92001950
57Tubular atrophy (HP:0000092)1.91874483
58Decreased circulating renin level (HP:0003351)1.90399418
59Hypothermia (HP:0002045)1.89545974
60Aplasia/Hypoplasia of the hallux (HP:0008362)1.87149053
61Progressive macrocephaly (HP:0004481)1.86877603
62Decreased central vision (HP:0007663)1.86459903
63Adactyly (HP:0009776)1.85597484
64Aplasia/Hypoplasia of the uvula (HP:0010293)1.84491520
65Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84473130
66Progressive inability to walk (HP:0002505)1.83242189
67Acute necrotizing encephalopathy (HP:0006965)1.82074265
68Abnormality of vitamin B metabolism (HP:0004340)1.81823052
69Concave nail (HP:0001598)1.80214030
70Sclerocornea (HP:0000647)1.78855936
71Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.78638970
72Postaxial hand polydactyly (HP:0001162)1.78477614
73Ketoacidosis (HP:0001993)1.78117018
74IgG deficiency (HP:0004315)1.77682334
75Abnormality of the phalanges of the 5th finger (HP:0004213)1.77608172
76Short hallux (HP:0010109)1.77498213
77Specific learning disability (HP:0001328)1.77004196
78Fibular aplasia (HP:0002990)1.76266334
79Bile duct proliferation (HP:0001408)1.76104455
80Abnormal biliary tract physiology (HP:0012439)1.76104455
81Intestinal atresia (HP:0011100)1.75508541
82Abnormality of DNA repair (HP:0003254)1.75097400
83Abnormality of the nasal septum (HP:0000419)1.74529142
84Focal motor seizures (HP:0011153)1.74169832
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.73912695
86Inability to walk (HP:0002540)1.73198296
87Congenital hepatic fibrosis (HP:0002612)1.72830880
88Polydipsia (HP:0001959)1.72378247
89Abnormal drinking behavior (HP:0030082)1.72378247
90Poor coordination (HP:0002370)1.72129215
91Febrile seizures (HP:0002373)1.69765370
92Postaxial foot polydactyly (HP:0001830)1.69096942
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.68268863
94Absent/shortened dynein arms (HP:0200106)1.68268863
95Tented upper lip vermilion (HP:0010804)1.66855561
96Hamartoma of the eye (HP:0010568)1.66302790
97Aplasia/Hypoplasia of the spleen (HP:0010451)1.64556243
98Furrowed tongue (HP:0000221)1.64464984
99Asplenia (HP:0001746)1.63727322
100Retinitis pigmentosa (HP:0000510)1.63471092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.03817041
2MAP4K23.53085277
3PINK12.94714770
4WNK32.80317518
5GRK12.75323688
6MAP3K42.50492377
7CASK2.47819922
8MAPK132.32967529
9ACVR1B2.09169996
10BMPR1B2.07909501
11ADRBK21.94374803
12INSRR1.85614616
13TNIK1.79764000
14TAOK31.69506626
15MAP2K71.66420205
16NUAK11.61806789
17PAK31.59725584
18TXK1.53180133
19EPHA31.50533759
20PLK21.44955735
21MARK11.42668679
22DYRK21.39375618
23CSNK1G11.22564218
24BCKDK1.16505607
25CSNK1G21.14687335
26SIK21.12227523
27ERBB31.11174600
28TRIM281.08123205
29ZAK1.07118867
30PRKCE1.04746059
31CSNK1G31.00883817
32PNCK0.99853258
33ADRBK10.98535226
34NLK0.95626718
35CSNK1A1L0.93335322
36FGFR20.92231847
37TIE10.91117410
38PRKCG0.90553047
39SGK20.89330019
40DAPK20.84200756
41IKBKB0.83833567
42TLK10.83210531
43CAMKK20.82282004
44DYRK30.76907474
45FER0.76382926
46TEC0.75863945
47OXSR10.75691587
48PASK0.75335402
49BCR0.72916029
50FLT30.71697371
51CAMK2A0.64662314
52PHKG10.63406527
53PHKG20.63406527
54IRAK10.63366990
55GRK50.63246140
56GRK70.62870867
57PRKCQ0.62648983
58CSNK1A10.62216075
59STK38L0.61904312
60SGK4940.61845127
61SGK2230.61845127
62AKT30.61088776
63MST40.60685235
64STK390.60277771
65MAPKAPK30.59624248
66WEE10.57963786
67TNK20.57253040
68PRKD20.54607198
69STK110.53897041
70TGFBR10.53756179
71DYRK1A0.53406825
72ERBB20.51989111
73PRKACA0.51709802
74BMPR20.51497999
75NTRK20.51402076
76PRKCZ0.51352993
77SRPK10.50901973
78WNK40.48646020
79MAP3K90.47337560
80CAMK2B0.46805303
81RPS6KA50.46014840
82MAP2K40.45176382
83ITK0.44835110
84SYK0.44174152
85CSNK1D0.43794473
86SGK10.43181099
87LYN0.42360600
88GRK60.42196207
89NTRK30.41511788
90IKBKE0.39926790
91PIK3CA0.39079403
92VRK10.38378023
93PRKCI0.38334255
94PTK2B0.37033236
95PKN10.36657347
96PLK40.36271411
97MAP2K60.36263059
98ABL10.35845508
99NME10.34289842
100PRKCA0.33272444

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.26501221
2Nicotine addiction_Homo sapiens_hsa050332.95226132
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.89354981
4Phototransduction_Homo sapiens_hsa047442.78158463
5Protein export_Homo sapiens_hsa030602.32102333
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.07573111
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95475784
8Oxidative phosphorylation_Homo sapiens_hsa001901.92235016
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81301344
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73183761
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71525169
12Propanoate metabolism_Homo sapiens_hsa006401.69308452
13Collecting duct acid secretion_Homo sapiens_hsa049661.69057353
14Sulfur metabolism_Homo sapiens_hsa009201.64515185
15Linoleic acid metabolism_Homo sapiens_hsa005911.64302609
16Morphine addiction_Homo sapiens_hsa050321.60252442
17Butanoate metabolism_Homo sapiens_hsa006501.58329266
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58132930
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53394741
20Tryptophan metabolism_Homo sapiens_hsa003801.52659075
21Ether lipid metabolism_Homo sapiens_hsa005651.51977159
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48608178
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45310718
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.45058754
25Taste transduction_Homo sapiens_hsa047421.44844145
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40726744
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39160116
28Chemical carcinogenesis_Homo sapiens_hsa052041.38748203
29Fanconi anemia pathway_Homo sapiens_hsa034601.38610907
30GABAergic synapse_Homo sapiens_hsa047271.31888744
31Parkinsons disease_Homo sapiens_hsa050121.30292448
32Nitrogen metabolism_Homo sapiens_hsa009101.29255391
33Circadian entrainment_Homo sapiens_hsa047131.29154988
34Homologous recombination_Homo sapiens_hsa034401.28509385
35Insulin secretion_Homo sapiens_hsa049111.26670473
36RNA degradation_Homo sapiens_hsa030181.25971024
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25631557
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25352774
39Peroxisome_Homo sapiens_hsa041461.23816246
40Primary immunodeficiency_Homo sapiens_hsa053401.21267290
41Olfactory transduction_Homo sapiens_hsa047401.20795776
42Glutamatergic synapse_Homo sapiens_hsa047241.19893143
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18124477
44Basal transcription factors_Homo sapiens_hsa030221.16455630
45Selenocompound metabolism_Homo sapiens_hsa004501.15449793
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14150802
47Regulation of autophagy_Homo sapiens_hsa041401.11582550
48Retinol metabolism_Homo sapiens_hsa008301.06891961
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.06730786
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05971169
51Non-homologous end-joining_Homo sapiens_hsa034501.04831248
52Serotonergic synapse_Homo sapiens_hsa047261.02970180
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00889877
54Caffeine metabolism_Homo sapiens_hsa002320.96310535
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.95715164
56Dorso-ventral axis formation_Homo sapiens_hsa043200.94364795
57Alzheimers disease_Homo sapiens_hsa050100.93358229
58RNA polymerase_Homo sapiens_hsa030200.90336960
59Dopaminergic synapse_Homo sapiens_hsa047280.88794727
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88249352
61Glycerolipid metabolism_Homo sapiens_hsa005610.86841470
62Cocaine addiction_Homo sapiens_hsa050300.86543522
63Type II diabetes mellitus_Homo sapiens_hsa049300.85839061
64Type I diabetes mellitus_Homo sapiens_hsa049400.83829178
65beta-Alanine metabolism_Homo sapiens_hsa004100.80290931
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79583735
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78715453
68Amphetamine addiction_Homo sapiens_hsa050310.72075158
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70134347
70Renin secretion_Homo sapiens_hsa049240.69015159
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68399412
72Asthma_Homo sapiens_hsa053100.67510806
73ABC transporters_Homo sapiens_hsa020100.67012190
74Steroid biosynthesis_Homo sapiens_hsa001000.66359991
75Calcium signaling pathway_Homo sapiens_hsa040200.65228330
76Arachidonic acid metabolism_Homo sapiens_hsa005900.65196022
77Salivary secretion_Homo sapiens_hsa049700.64268646
78Ovarian steroidogenesis_Homo sapiens_hsa049130.62800883
79Rheumatoid arthritis_Homo sapiens_hsa053230.60299202
80Axon guidance_Homo sapiens_hsa043600.59683667
81Histidine metabolism_Homo sapiens_hsa003400.59272034
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58803171
83Graft-versus-host disease_Homo sapiens_hsa053320.57666215
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56672936
85Huntingtons disease_Homo sapiens_hsa050160.56506274
86Cardiac muscle contraction_Homo sapiens_hsa042600.55907058
87Synaptic vesicle cycle_Homo sapiens_hsa047210.54922362
88Long-term depression_Homo sapiens_hsa047300.53456189
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52123731
90Metabolic pathways_Homo sapiens_hsa011000.50546469
91Cholinergic synapse_Homo sapiens_hsa047250.49264872
92Autoimmune thyroid disease_Homo sapiens_hsa053200.47971679
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42895852
94Allograft rejection_Homo sapiens_hsa053300.42336237
95Purine metabolism_Homo sapiens_hsa002300.41527077
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41213674
97Hematopoietic cell lineage_Homo sapiens_hsa046400.40655191
98Circadian rhythm_Homo sapiens_hsa047100.40556293
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.40282232
100Fatty acid elongation_Homo sapiens_hsa000620.40152919

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