ZNF835

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.53626842
2water-soluble vitamin biosynthetic process (GO:0042364)4.17038305
3L-fucose catabolic process (GO:0042355)4.08102544
4fucose catabolic process (GO:0019317)4.08102544
5L-fucose metabolic process (GO:0042354)4.08102544
6DNA deamination (GO:0045006)3.86118832
7platelet dense granule organization (GO:0060155)3.63558806
8kidney morphogenesis (GO:0060993)3.51056593
9detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47520013
10indolalkylamine metabolic process (GO:0006586)3.45510292
11cellular ketone body metabolic process (GO:0046950)3.42972913
12indole-containing compound catabolic process (GO:0042436)3.37702625
13indolalkylamine catabolic process (GO:0046218)3.37702625
14tryptophan catabolic process (GO:0006569)3.37702625
15response to pheromone (GO:0019236)3.36078657
16respiratory chain complex IV assembly (GO:0008535)3.35696805
17piRNA metabolic process (GO:0034587)3.31005174
18axoneme assembly (GO:0035082)3.24207261
19negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16750350
20negative regulation of telomere maintenance (GO:0032205)3.14674624
21glycerophospholipid catabolic process (GO:0046475)3.14224112
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12834870
23ketone body metabolic process (GO:1902224)3.12779717
24protein complex biogenesis (GO:0070271)3.12237094
25tryptophan metabolic process (GO:0006568)3.08866476
26epithelial cilium movement (GO:0003351)3.07480397
27kynurenine metabolic process (GO:0070189)3.07462154
28retinal cone cell development (GO:0046549)3.05537270
29regulation of hexokinase activity (GO:1903299)3.04717141
30regulation of glucokinase activity (GO:0033131)3.04717141
31detection of light stimulus involved in sensory perception (GO:0050962)3.03795995
32detection of light stimulus involved in visual perception (GO:0050908)3.03795995
33cytochrome complex assembly (GO:0017004)2.98725768
34cornea development in camera-type eye (GO:0061303)2.97685840
35protein polyglutamylation (GO:0018095)2.95570975
36somite development (GO:0061053)2.93074621
37adaptation of signaling pathway (GO:0023058)2.91702425
38preassembly of GPI anchor in ER membrane (GO:0016254)2.90538097
39protein K6-linked ubiquitination (GO:0085020)2.90362808
40mitochondrial respiratory chain complex assembly (GO:0033108)2.86632734
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86509199
42mitochondrial respiratory chain complex I assembly (GO:0032981)2.86509199
43NADH dehydrogenase complex assembly (GO:0010257)2.86509199
44regulation of action potential (GO:0098900)2.82996120
45DNA methylation involved in gamete generation (GO:0043046)2.82855826
46neural tube formation (GO:0001841)2.79415264
47reflex (GO:0060004)2.74795785
48regulation of neurotransmitter uptake (GO:0051580)2.70749883
49neuron fate determination (GO:0048664)2.68825412
50neuronal action potential (GO:0019228)2.68685274
51nonmotile primary cilium assembly (GO:0035058)2.68013563
52indole-containing compound metabolic process (GO:0042430)2.67606956
53amine catabolic process (GO:0009310)2.65960451
54cellular biogenic amine catabolic process (GO:0042402)2.65960451
55photoreceptor cell development (GO:0042461)2.63574095
56gamma-aminobutyric acid transport (GO:0015812)2.62873158
57behavioral response to ethanol (GO:0048149)2.62525739
58cilium morphogenesis (GO:0060271)2.61562291
59nephron tubule morphogenesis (GO:0072078)2.60209893
60nephron epithelium morphogenesis (GO:0072088)2.60209893
61positive regulation of oligodendrocyte differentiation (GO:0048714)2.58895837
62photoreceptor cell maintenance (GO:0045494)2.57182184
63protein K11-linked deubiquitination (GO:0035871)2.54993931
64neuronal action potential propagation (GO:0019227)2.54707578
65cilium movement (GO:0003341)2.54459603
66negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53576356
67male meiosis I (GO:0007141)2.53379761
68protein-cofactor linkage (GO:0018065)2.53122860
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.52011357
70rRNA catabolic process (GO:0016075)2.51498059
71dentate gyrus development (GO:0021542)2.51021923
72mannosylation (GO:0097502)2.50712918
73negative regulation of DNA-dependent DNA replication (GO:2000104)2.50362609
74recombinational repair (GO:0000725)2.49354619
75cilium organization (GO:0044782)2.49314277
76positive regulation of meiosis (GO:0045836)2.48897097
77double-strand break repair via homologous recombination (GO:0000724)2.47910130
78nucleobase catabolic process (GO:0046113)2.47716846
79regulation of meiosis I (GO:0060631)2.47683363
80rhodopsin mediated signaling pathway (GO:0016056)2.47612143
81regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47257331
82synaptic transmission, cholinergic (GO:0007271)2.45626268
83startle response (GO:0001964)2.45596409
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44983806
85negative regulation of systemic arterial blood pressure (GO:0003085)2.44846606
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44035260
87pyrimidine nucleobase catabolic process (GO:0006208)2.43202255
88regulation of telomere maintenance (GO:0032204)2.42673229
89cell proliferation in forebrain (GO:0021846)2.42325684
90cilium assembly (GO:0042384)2.41581978
91dopamine transport (GO:0015872)2.41447950
92endocrine pancreas development (GO:0031018)2.41171190
93spinal cord motor neuron differentiation (GO:0021522)2.40482266
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39967470
95dendritic spine morphogenesis (GO:0060997)2.38186806
96regulation of cilium movement (GO:0003352)2.38090167
97transmission of nerve impulse (GO:0019226)2.37991583
98auditory receptor cell stereocilium organization (GO:0060088)2.37399572
99sulfation (GO:0051923)2.36854566
100signal peptide processing (GO:0006465)2.36502178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.57209990
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40706936
3GBX2_23144817_ChIP-Seq_PC3_Human3.02349488
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90027889
5VDR_22108803_ChIP-Seq_LS180_Human2.86376079
6EZH2_22144423_ChIP-Seq_EOC_Human2.82307788
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64397213
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63844044
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27197750
10IGF1R_20145208_ChIP-Seq_DFB_Human2.20772157
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14733242
12FUS_26573619_Chip-Seq_HEK293_Human2.08347268
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07557892
14P300_19829295_ChIP-Seq_ESCs_Human2.02698849
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.02608609
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.97218988
17TAF15_26573619_Chip-Seq_HEK293_Human1.96974406
18* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96663825
19EWS_26573619_Chip-Seq_HEK293_Human1.89490092
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82443243
21ER_23166858_ChIP-Seq_MCF-7_Human1.80028241
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78967133
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70182010
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66113039
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64906179
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64589156
27* BCAT_22108803_ChIP-Seq_LS180_Human1.63141776
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.59468610
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.59322235
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58969979
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.58703226
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58357439
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53827866
34SMAD4_21799915_ChIP-Seq_A2780_Human1.52800851
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52364844
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52292025
37* AR_25329375_ChIP-Seq_VCAP_Human1.50854847
38REST_21632747_ChIP-Seq_MESCs_Mouse1.50249608
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49552315
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49147293
41STAT3_23295773_ChIP-Seq_U87_Human1.46583690
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46337478
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44982177
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44582084
45* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44190266
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43229624
47TP53_22573176_ChIP-Seq_HFKS_Human1.43110144
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42678698
49* TCF4_23295773_ChIP-Seq_U87_Human1.41837510
50IRF1_19129219_ChIP-ChIP_H3396_Human1.41498025
51* CBP_20019798_ChIP-Seq_JUKART_Human1.41494180
52* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41494180
53NANOG_19829295_ChIP-Seq_ESCs_Human1.40911957
54SOX2_19829295_ChIP-Seq_ESCs_Human1.40911957
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39145704
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39145704
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.35060916
58MYC_18940864_ChIP-ChIP_HL60_Human1.32396434
59TCF4_22108803_ChIP-Seq_LS180_Human1.29221543
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28976637
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28366446
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28175601
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27449483
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.27449483
65* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26526920
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26493917
67RNF2_27304074_Chip-Seq_NSC_Mouse1.24429033
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.23705604
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.20860329
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.20816800
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20169404
72RUNX2_22187159_ChIP-Seq_PCA_Human1.20055870
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16298358
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16060438
75NCOR_22424771_ChIP-Seq_293T_Human1.14517308
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.13273434
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13184976
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13043952
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.12468599
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.11468560
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.10250721
82* AR_20517297_ChIP-Seq_VCAP_Human1.10037860
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.09745652
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09663590
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09141757
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08146387
87P53_22387025_ChIP-Seq_ESCs_Mouse1.07364004
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.06331411
89JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06263734
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05845977
91CDX2_22108803_ChIP-Seq_LS180_Human1.04544637
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.04261824
93HOXB7_26014856_ChIP-Seq_BT474_Human1.03769439
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02965279
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02928406
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.00451505
97AR_21572438_ChIP-Seq_LNCaP_Human0.99958032
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.99649047
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99574725
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.97461306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.18708543
2MP0002837_dystrophic_cardiac_calcinosis3.17094492
3MP0006292_abnormal_olfactory_placode3.04297153
4MP0003195_calcinosis2.72706627
5MP0003787_abnormal_imprinting2.71338009
6MP0005646_abnormal_pituitary_gland2.71029568
7MP0001968_abnormal_touch/_nociception2.47615149
8MP0002102_abnormal_ear_morphology2.31709357
9MP0005551_abnormal_eye_electrophysiolog2.22151985
10MP0003646_muscle_fatigue2.08218120
11MP0002876_abnormal_thyroid_physiology2.06667835
12MP0005645_abnormal_hypothalamus_physiol2.04129147
13MP0004885_abnormal_endolymph2.01034890
14MP0006072_abnormal_retinal_apoptosis1.98105705
15MP0000569_abnormal_digit_pigmentation1.96360537
16MP0002736_abnormal_nociception_after1.94730925
17MP0009745_abnormal_behavioral_response1.91730394
18MP0008872_abnormal_physiological_respon1.88860021
19MP0000631_abnormal_neuroendocrine_gland1.84660586
20MP0002272_abnormal_nervous_system1.82366282
21MP0009046_muscle_twitch1.79329550
22MP0002938_white_spotting1.70491052
23MP0008875_abnormal_xenobiotic_pharmacok1.66067871
24MP0003880_abnormal_central_pattern1.64238330
25MP0005379_endocrine/exocrine_gland_phen1.64135319
26MP0002638_abnormal_pupillary_reflex1.62506385
27MP0000372_irregular_coat_pigmentation1.61310004
28MP0001986_abnormal_taste_sensitivity1.60739390
29MP0001501_abnormal_sleep_pattern1.60348569
30MP0002163_abnormal_gland_morphology1.59946785
31MP0000427_abnormal_hair_cycle1.57234862
32MP0002653_abnormal_ependyma_morphology1.55981977
33MP0001485_abnormal_pinna_reflex1.51635411
34MP0004043_abnormal_pH_regulation1.50207142
35MP0005253_abnormal_eye_physiology1.50026185
36MP0004142_abnormal_muscle_tone1.49594056
37MP0001984_abnormal_olfaction1.47994059
38MP0001486_abnormal_startle_reflex1.46666197
39MP0003283_abnormal_digestive_organ1.43822656
40MP0002138_abnormal_hepatobiliary_system1.38484919
41MP0004147_increased_porphyrin_level1.38256151
42MP0004133_heterotaxia1.37968700
43MP0002928_abnormal_bile_duct1.37358086
44MP0002064_seizures1.36296437
45MP0005084_abnormal_gallbladder_morpholo1.33625592
46MP0003121_genomic_imprinting1.32571692
47MP0006276_abnormal_autonomic_nervous1.32073232
48MP0002557_abnormal_social/conspecific_i1.32057941
49MP0003136_yellow_coat_color1.31062960
50MP0003011_delayed_dark_adaptation1.30356036
51MP0002735_abnormal_chemical_nociception1.29793746
52MP0002572_abnormal_emotion/affect_behav1.28226045
53MP0002160_abnormal_reproductive_system1.27886905
54MP0005174_abnormal_tail_pigmentation1.27027663
55MP0005389_reproductive_system_phenotype1.26921425
56MP0003122_maternal_imprinting1.24269388
57MP0002234_abnormal_pharynx_morphology1.23707770
58MP0002733_abnormal_thermal_nociception1.23157965
59MP0005075_abnormal_melanosome_morpholog1.21433444
60MP0001970_abnormal_pain_threshold1.19965927
61MP0004924_abnormal_behavior1.19076905
62MP0005386_behavior/neurological_phenoty1.19076905
63MP0008789_abnormal_olfactory_epithelium1.18175136
64MP0003718_maternal_effect1.17612096
65MP0001529_abnormal_vocalization1.10329506
66MP0002067_abnormal_sensory_capabilities1.09762876
67MP0003635_abnormal_synaptic_transmissio1.09169548
68MP0002693_abnormal_pancreas_physiology1.06347272
69MP0005195_abnormal_posterior_eye1.05707792
70MP0001944_abnormal_pancreas_morphology1.04364295
71MP0002909_abnormal_adrenal_gland1.04077968
72MP0002734_abnormal_mechanical_nocicepti1.03588150
73MP0000383_abnormal_hair_follicle1.02892757
74MP0002063_abnormal_learning/memory/cond1.02683528
75MP0004742_abnormal_vestibular_system1.02385122
76MP0004145_abnormal_muscle_electrophysio1.01948530
77MP0001919_abnormal_reproductive_system1.01483133
78MP0001905_abnormal_dopamine_level1.01475284
79MP0010386_abnormal_urinary_bladder0.97249795
80MP0000015_abnormal_ear_pigmentation0.93562635
81MP0001764_abnormal_homeostasis0.91555607
82MP0003137_abnormal_impulse_conducting0.89715911
83MP0000026_abnormal_inner_ear0.88177049
84MP0000778_abnormal_nervous_system0.87774443
85MP0002095_abnormal_skin_pigmentation0.86059986
86MP0002751_abnormal_autonomic_nervous0.85201570
87MP0005332_abnormal_amino_acid0.84542152
88MP0008058_abnormal_DNA_repair0.84485695
89MP0001324_abnormal_eye_pigmentation0.83793537
90MP0005410_abnormal_fertilization0.82794100
91MP0002184_abnormal_innervation0.81419348
92MP0001502_abnormal_circadian_rhythm0.80823521
93MP0001963_abnormal_hearing_physiology0.80784274
94MP0002229_neurodegeneration0.79533122
95MP0002752_abnormal_somatic_nervous0.79124236
96MP0002277_abnormal_respiratory_mucosa0.78749013
97MP0004215_abnormal_myocardial_fiber0.77753479
98MP0005394_taste/olfaction_phenotype0.76189755
99MP0005499_abnormal_olfactory_system0.76189755
100MP0005636_abnormal_mineral_homeostasis0.75319347

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.29094130
2Pancreatic fibrosis (HP:0100732)4.00358624
3Congenital stationary night blindness (HP:0007642)3.97316764
4Abnormality of midbrain morphology (HP:0002418)3.64052848
5Molar tooth sign on MRI (HP:0002419)3.64052848
6True hermaphroditism (HP:0010459)3.62010457
7Nephronophthisis (HP:0000090)3.58478438
8Abnormality of the renal cortex (HP:0011035)3.48401744
9Abnormality of the renal medulla (HP:0100957)3.18254866
10Medial flaring of the eyebrow (HP:0010747)3.02265915
11Type II lissencephaly (HP:0007260)2.94476629
12Hyperventilation (HP:0002883)2.94047622
13Polydipsia (HP:0001959)2.93719512
14Abnormal drinking behavior (HP:0030082)2.93719512
15Pendular nystagmus (HP:0012043)2.88538553
16Cystic liver disease (HP:0006706)2.83297861
17Abolished electroretinogram (ERG) (HP:0000550)2.65998666
18Renal cortical cysts (HP:0000803)2.64546097
19Progressive cerebellar ataxia (HP:0002073)2.60795741
20Tubular atrophy (HP:0000092)2.60598085
21Gaze-evoked nystagmus (HP:0000640)2.55336396
22Large for gestational age (HP:0001520)2.54051074
23Abnormal rod and cone electroretinograms (HP:0008323)2.48774628
24Abnormality of the labia minora (HP:0012880)2.46299281
25Febrile seizures (HP:0002373)2.43971976
26Gait imbalance (HP:0002141)2.41039122
27Ketoacidosis (HP:0001993)2.34030502
28Hypothermia (HP:0002045)2.33672994
29Attenuation of retinal blood vessels (HP:0007843)2.33200928
30Congenital primary aphakia (HP:0007707)2.30429180
31Polyuria (HP:0000103)2.29307593
32Intestinal atresia (HP:0011100)2.26858636
33Sclerocornea (HP:0000647)2.24091833
34Furrowed tongue (HP:0000221)2.22868328
35Nephrogenic diabetes insipidus (HP:0009806)2.20740942
36Methylmalonic acidemia (HP:0002912)2.18908748
37Ketosis (HP:0001946)2.18327478
38Hypomagnesemia (HP:0002917)2.18276087
39Hemiparesis (HP:0001269)2.17376175
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.15778248
41Mitochondrial inheritance (HP:0001427)2.11347068
42Broad-based gait (HP:0002136)2.11023821
43Hepatic necrosis (HP:0002605)2.10624904
44Congenital hepatic fibrosis (HP:0002612)2.09764153
45Focal motor seizures (HP:0011153)2.09140758
46Increased corneal curvature (HP:0100692)2.08944837
47Keratoconus (HP:0000563)2.08944837
48Chronic hepatic failure (HP:0100626)2.08376222
49Inability to walk (HP:0002540)2.06074185
50Decreased central vision (HP:0007663)2.05489375
51Oligodactyly (hands) (HP:0001180)2.04932860
52Protruding tongue (HP:0010808)2.03995547
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.03309728
54Hypoplasia of the fovea (HP:0007750)2.03309728
55Chorioretinal atrophy (HP:0000533)2.02952108
56Optic nerve hypoplasia (HP:0000609)2.02797404
57Genetic anticipation (HP:0003743)2.02559857
58Anencephaly (HP:0002323)2.02062066
59Lissencephaly (HP:0001339)2.00508675
60Neoplasm of the adrenal cortex (HP:0100641)2.00320782
61Increased CSF lactate (HP:0002490)1.99877698
62Hepatocellular necrosis (HP:0001404)1.99303212
63Decreased circulating renin level (HP:0003351)1.96999336
64Bile duct proliferation (HP:0001408)1.96500791
65Abnormal biliary tract physiology (HP:0012439)1.96500791
66Methylmalonic aciduria (HP:0012120)1.96386454
67Genital tract atresia (HP:0001827)1.95802124
68Male pseudohermaphroditism (HP:0000037)1.95662959
69Congenital, generalized hypertrichosis (HP:0004540)1.93704440
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92877635
71Acute necrotizing encephalopathy (HP:0006965)1.92480296
72Focal seizures (HP:0007359)1.90309895
73Progressive macrocephaly (HP:0004481)1.89085975
74Congenital sensorineural hearing impairment (HP:0008527)1.88765645
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.88052733
76Pachygyria (HP:0001302)1.87969159
77Progressive inability to walk (HP:0002505)1.87370957
78Dialeptic seizures (HP:0011146)1.85364151
79Abnormality of macular pigmentation (HP:0008002)1.84884305
80Postaxial foot polydactyly (HP:0001830)1.84253716
81Vaginal atresia (HP:0000148)1.83233789
82Cerebellar dysplasia (HP:0007033)1.82324334
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.81626564
84Abnormal urine output (HP:0012590)1.81405216
85Bony spicule pigmentary retinopathy (HP:0007737)1.80817326
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78307673
87Abnormality of alanine metabolism (HP:0010916)1.78307673
88Hyperalaninemia (HP:0003348)1.78307673
89Lipid accumulation in hepatocytes (HP:0006561)1.77747765
90Severe muscular hypotonia (HP:0006829)1.75988584
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.74885321
92Absent/shortened dynein arms (HP:0200106)1.74885321
93Asplenia (HP:0001746)1.74608723
94Colon cancer (HP:0003003)1.73980482
95Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73143937
96Abnormality of the fovea (HP:0000493)1.72446535
97Hyperglycinemia (HP:0002154)1.71749670
98Glycosuria (HP:0003076)1.71233201
99Abnormality of urine glucose concentration (HP:0011016)1.71233201
100Aplasia/hypoplasia of the uterus (HP:0008684)1.70870383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.84491143
2CASK2.95107806
3ADRBK22.88329872
4PINK12.74349904
5MAP4K22.72826176
6WNK32.66850698
7BMPR1B2.66716942
8ZAK2.49914871
9GRK12.49297726
10NUAK12.39071555
11WNK41.96834337
12TAOK31.96323873
13MAPK131.80065844
14OXSR11.77645672
15ACVR1B1.75331923
16DAPK21.73748740
17TNIK1.72818084
18INSRR1.65545823
19TLK11.60640496
20MARK11.59359181
21MAP3K41.57519966
22STK391.47130427
23MKNK21.37336600
24TIE11.37209527
25MAP2K61.27519776
26STK38L1.25698017
27PAK31.24603645
28PNCK1.22584166
29BRSK21.19199964
30FGFR21.18513562
31NTRK31.15743155
32DYRK21.14544715
33PLK21.09781097
34PHKG21.09390288
35PHKG11.09390288
36PRKCG1.05624040
37BCKDK0.97248154
38VRK10.96190653
39PRKCE0.94178310
40TXK0.93386509
41MAP2K70.92836366
42ADRBK10.92173328
43TRIM280.89970974
44NTRK20.84596686
45EPHA40.80811644
46NLK0.80144672
47PLK30.79891373
48WEE10.79767325
49CSNK1G20.77993576
50CSNK1G10.76343377
51TNK20.70171340
52TGFBR10.68105836
53ERBB30.66546804
54MAPK150.66101080
55MST40.64820824
56CAMKK20.64095888
57CSNK1G30.63996162
58IRAK10.62793654
59PRKCQ0.61916310
60STK110.59847640
61SGK20.59383345
62TSSK60.59040494
63PRKCI0.58576312
64CAMK2A0.56141629
65STK30.56117553
66PKN10.53665187
67PIK3CA0.52868734
68PRKCZ0.52120928
69PTK2B0.51893021
70MAP3K90.51128344
71CSNK1A10.50074592
72MAPKAPK50.47742555
73PRKACA0.46996319
74NME10.46604546
75PLK40.46280622
76MKNK10.45649587
77TEC0.41604182
78CSNK1A1L0.40815508
79VRK20.40578523
80PRKG10.40352925
81PLK10.40203122
82KIT0.39834002
83FLT30.39465738
84IKBKB0.39287959
85PRKAA10.39094339
86RPS6KA50.39054812
87CAMK10.38611329
88CDK30.38066161
89SGK2230.37952928
90SGK4940.37952928
91AKT30.37303370
92MAPKAPK30.36588178
93PRKAA20.36122035
94CAMK2D0.35530968
95GRK50.34835328
96PRKCA0.34218848
97CDK190.32040425
98ATM0.31135727
99GRK70.29736886
100OBSCN0.27961962

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.35509127
2Phototransduction_Homo sapiens_hsa047442.72570515
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61614359
4Protein export_Homo sapiens_hsa030602.57489757
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57238619
6Butanoate metabolism_Homo sapiens_hsa006502.53883062
7Linoleic acid metabolism_Homo sapiens_hsa005912.43526089
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30115152
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19231088
10Oxidative phosphorylation_Homo sapiens_hsa001902.10326014
11Nicotine addiction_Homo sapiens_hsa050332.03123852
12Nitrogen metabolism_Homo sapiens_hsa009101.99133729
13Selenocompound metabolism_Homo sapiens_hsa004501.97951740
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91296262
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89839921
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89498855
17Homologous recombination_Homo sapiens_hsa034401.86378272
18Tryptophan metabolism_Homo sapiens_hsa003801.85304611
19Ether lipid metabolism_Homo sapiens_hsa005651.76082913
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73858495
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63691570
22Basal transcription factors_Homo sapiens_hsa030221.61381843
23Caffeine metabolism_Homo sapiens_hsa002321.59228822
24Insulin secretion_Homo sapiens_hsa049111.58865529
25Propanoate metabolism_Homo sapiens_hsa006401.58764414
26Fanconi anemia pathway_Homo sapiens_hsa034601.54454632
27Parkinsons disease_Homo sapiens_hsa050121.41479134
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38192728
29Taste transduction_Homo sapiens_hsa047421.37613291
30RNA polymerase_Homo sapiens_hsa030201.31996975
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31344340
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29840365
33Morphine addiction_Homo sapiens_hsa050321.22649121
34Olfactory transduction_Homo sapiens_hsa047401.21326006
35RNA degradation_Homo sapiens_hsa030181.12525149
36Sulfur metabolism_Homo sapiens_hsa009201.10168133
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.09456687
38One carbon pool by folate_Homo sapiens_hsa006701.08285522
39Peroxisome_Homo sapiens_hsa041461.07712555
40Circadian entrainment_Homo sapiens_hsa047131.04333787
41Arachidonic acid metabolism_Homo sapiens_hsa005901.04084379
42Cardiac muscle contraction_Homo sapiens_hsa042601.02954892
43Ovarian steroidogenesis_Homo sapiens_hsa049131.02579378
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01660187
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.01159758
46Collecting duct acid secretion_Homo sapiens_hsa049661.01095618
47GABAergic synapse_Homo sapiens_hsa047271.00762331
48Chemical carcinogenesis_Homo sapiens_hsa052040.98132283
49Regulation of autophagy_Homo sapiens_hsa041400.97627140
50Alzheimers disease_Homo sapiens_hsa050100.92400876
51Retinol metabolism_Homo sapiens_hsa008300.92000929
52ABC transporters_Homo sapiens_hsa020100.91740848
53Serotonergic synapse_Homo sapiens_hsa047260.91528526
54Salivary secretion_Homo sapiens_hsa049700.91158517
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90736792
56Glutamatergic synapse_Homo sapiens_hsa047240.89611276
57Huntingtons disease_Homo sapiens_hsa050160.88903646
58beta-Alanine metabolism_Homo sapiens_hsa004100.88556423
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88129117
60Fat digestion and absorption_Homo sapiens_hsa049750.81927555
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.79328942
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75791021
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71691441
64Non-homologous end-joining_Homo sapiens_hsa034500.71480755
65Glycerolipid metabolism_Homo sapiens_hsa005610.71477966
66Dorso-ventral axis formation_Homo sapiens_hsa043200.70046908
67Histidine metabolism_Homo sapiens_hsa003400.70044310
68Mineral absorption_Homo sapiens_hsa049780.68498076
69Fatty acid degradation_Homo sapiens_hsa000710.68444977
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66002131
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65673509
72Metabolic pathways_Homo sapiens_hsa011000.60586071
73Type I diabetes mellitus_Homo sapiens_hsa049400.59603606
74Amphetamine addiction_Homo sapiens_hsa050310.57526409
75Fatty acid elongation_Homo sapiens_hsa000620.57363028
76Calcium signaling pathway_Homo sapiens_hsa040200.57255244
77Purine metabolism_Homo sapiens_hsa002300.56674666
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54382707
79Long-term depression_Homo sapiens_hsa047300.53138200
80Dopaminergic synapse_Homo sapiens_hsa047280.52661142
81Fatty acid metabolism_Homo sapiens_hsa012120.50190363
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48546808
83Steroid biosynthesis_Homo sapiens_hsa001000.46934763
84Circadian rhythm_Homo sapiens_hsa047100.45048443
85Renin secretion_Homo sapiens_hsa049240.43475927
86cAMP signaling pathway_Homo sapiens_hsa040240.42496032
87Vitamin B6 metabolism_Homo sapiens_hsa007500.41443014
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41350431
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41284611
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40522996
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.40430920
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.40344645
93Cocaine addiction_Homo sapiens_hsa050300.39249653
94Asthma_Homo sapiens_hsa053100.39233189
95Pyrimidine metabolism_Homo sapiens_hsa002400.36970582
96Pancreatic secretion_Homo sapiens_hsa049720.36933631
97Thyroid hormone synthesis_Homo sapiens_hsa049180.33212341
98Hedgehog signaling pathway_Homo sapiens_hsa043400.32831012
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31860202
100Gastric acid secretion_Homo sapiens_hsa049710.31648014

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