ZNF83

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.46847861
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39959168
3epithelial cilium movement (GO:0003351)3.66820218
4interkinetic nuclear migration (GO:0022027)3.55222528
5negative regulation of cytosolic calcium ion concentration (GO:0051481)3.50865766
6response to pheromone (GO:0019236)3.48545699
7dendritic spine morphogenesis (GO:0060997)3.38096049
8gamma-aminobutyric acid transport (GO:0015812)3.28864593
9regulation of cilium movement (GO:0003352)3.23078765
10protein localization to cilium (GO:0061512)3.16723414
11presynaptic membrane organization (GO:0097090)3.15408101
12protein localization to Golgi apparatus (GO:0034067)3.14607987
13cilium movement (GO:0003341)3.12458131
14establishment of protein localization to Golgi (GO:0072600)3.11004293
15tachykinin receptor signaling pathway (GO:0007217)3.10066832
16nonmotile primary cilium assembly (GO:0035058)3.04158489
17presynaptic membrane assembly (GO:0097105)3.03947770
18transmission of nerve impulse (GO:0019226)2.99000825
19nephron tubule morphogenesis (GO:0072078)2.97328571
20nephron epithelium morphogenesis (GO:0072088)2.97328571
21auditory receptor cell differentiation (GO:0042491)2.96845708
22behavioral response to ethanol (GO:0048149)2.96441606
23axoneme assembly (GO:0035082)2.91778280
24detection of light stimulus involved in visual perception (GO:0050908)2.90924587
25detection of light stimulus involved in sensory perception (GO:0050962)2.90924587
26cilium or flagellum-dependent cell motility (GO:0001539)2.85273616
27intraciliary transport (GO:0042073)2.85112260
28neural tube formation (GO:0001841)2.82287535
29indolalkylamine metabolic process (GO:0006586)2.80757786
30parturition (GO:0007567)2.80238771
31histone H3-K4 trimethylation (GO:0080182)2.78538787
32kidney morphogenesis (GO:0060993)2.74006956
33cilium morphogenesis (GO:0060271)2.72268093
34photoreceptor cell maintenance (GO:0045494)2.68910767
35central nervous system myelination (GO:0022010)2.68889380
36axon ensheathment in central nervous system (GO:0032291)2.68889380
37peristalsis (GO:0030432)2.67364870
38pyrimidine nucleobase catabolic process (GO:0006208)2.66687102
39tryptophan catabolic process (GO:0006569)2.65448554
40indole-containing compound catabolic process (GO:0042436)2.65448554
41indolalkylamine catabolic process (GO:0046218)2.65448554
42cilium organization (GO:0044782)2.64557426
43regulation of collateral sprouting (GO:0048670)2.62741032
44cilium assembly (GO:0042384)2.62334115
45cornea development in camera-type eye (GO:0061303)2.60727664
46brain morphogenesis (GO:0048854)2.59442462
47detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59293820
48protein targeting to Golgi (GO:0000042)2.59199003
49renal tubule morphogenesis (GO:0061333)2.58209492
50dentate gyrus development (GO:0021542)2.57986340
51cellular ketone body metabolic process (GO:0046950)2.55435048
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55173686
53limb development (GO:0060173)2.54825809
54appendage development (GO:0048736)2.54825809
55head development (GO:0060322)2.53634972
56estrogen biosynthetic process (GO:0006703)2.52917168
57phasic smooth muscle contraction (GO:0014821)2.52174975
58positive regulation of growth hormone secretion (GO:0060124)2.50333826
59snRNA transcription (GO:0009301)2.49139240
60neuronal action potential (GO:0019228)2.48872999
61protein polyglutamylation (GO:0018095)2.46800917
62regulation of female gonad development (GO:2000194)2.46006523
63negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45982210
64centriole replication (GO:0007099)2.45804269
65retinal cone cell development (GO:0046549)2.45003692
66retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43159383
67sulfation (GO:0051923)2.42929044
68substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.40802194
69substrate-independent telencephalic tangential migration (GO:0021826)2.40802194
70cAMP catabolic process (GO:0006198)2.39741248
71auditory behavior (GO:0031223)2.39704916
72reflex (GO:0060004)2.39161770
73negative regulation of systemic arterial blood pressure (GO:0003085)2.36934856
74fucose catabolic process (GO:0019317)2.36449915
75L-fucose metabolic process (GO:0042354)2.36449915
76L-fucose catabolic process (GO:0042355)2.36449915
77inner ear receptor stereocilium organization (GO:0060122)2.34402701
78photoreceptor cell development (GO:0042461)2.34125596
79positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.33186639
80monoubiquitinated protein deubiquitination (GO:0035520)2.30875628
81negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.30579392
82negative regulation of translation, ncRNA-mediated (GO:0040033)2.30579392
83regulation of translation, ncRNA-mediated (GO:0045974)2.30579392
84regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29999557
85forebrain morphogenesis (GO:0048853)2.29889988
86rhodopsin mediated signaling pathway (GO:0016056)2.29160224
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28983662
88nucleobase catabolic process (GO:0046113)2.27891067
89nucleus localization (GO:0051647)2.27664315
90negative regulation of mast cell activation (GO:0033004)2.27611093
91prostate gland growth (GO:0060736)2.26848481
92membrane depolarization during action potential (GO:0086010)2.26437249
93synapse assembly (GO:0007416)2.26007237
94regulation of sarcomere organization (GO:0060297)2.25823749
95cyclic nucleotide catabolic process (GO:0009214)2.25590403
96neuronal action potential propagation (GO:0019227)2.25071878
97regulation of microtubule-based movement (GO:0060632)2.24799003
98axonal fasciculation (GO:0007413)2.24083166
99urinary tract smooth muscle contraction (GO:0014848)2.22703567
100cellular response to sterol (GO:0036315)2.22504584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.22731390
2GBX2_23144817_ChIP-Seq_PC3_Human3.21022642
3ZNF274_21170338_ChIP-Seq_K562_Hela2.94015612
4VDR_22108803_ChIP-Seq_LS180_Human2.51158804
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47880360
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47521835
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34860510
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27525177
9IGF1R_20145208_ChIP-Seq_DFB_Human2.21074086
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17280116
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.06001820
12FUS_26573619_Chip-Seq_HEK293_Human1.99122182
13TAF15_26573619_Chip-Seq_HEK293_Human1.97565375
14PIAS1_25552417_ChIP-Seq_VCAP_Human1.95442970
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89935135
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89899820
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88139525
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.84599976
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82818237
20ER_23166858_ChIP-Seq_MCF-7_Human1.81748239
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80233865
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78163042
23P300_19829295_ChIP-Seq_ESCs_Human1.77672439
24SMAD4_21799915_ChIP-Seq_A2780_Human1.75105502
25EWS_26573619_Chip-Seq_HEK293_Human1.74337263
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67644586
27STAT3_23295773_ChIP-Seq_U87_Human1.63331827
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60313789
29REST_21632747_ChIP-Seq_MESCs_Mouse1.56351853
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.56227961
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55301562
32TCF4_23295773_ChIP-Seq_U87_Human1.52651378
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51508389
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51459012
35BCAT_22108803_ChIP-Seq_LS180_Human1.51013712
36AR_25329375_ChIP-Seq_VCAP_Human1.48109121
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47208543
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46862027
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46862027
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46365200
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45842267
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.42435864
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40562444
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38215675
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36013425
46CBP_20019798_ChIP-Seq_JUKART_Human1.36013425
47DROSHA_22980978_ChIP-Seq_HELA_Human1.35808945
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34813864
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33287934
50RUNX2_22187159_ChIP-Seq_PCA_Human1.31501468
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30122232
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29281895
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27899575
54RNF2_27304074_Chip-Seq_NSC_Mouse1.27839900
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27076291
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.26997715
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25338326
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24661160
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24506082
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24241037
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.24215509
62AR_21572438_ChIP-Seq_LNCaP_Human1.23854797
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.23585708
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21793974
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21680262
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.20840645
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20416736
68IRF1_19129219_ChIP-ChIP_H3396_Human1.20107972
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19970393
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19266932
71* TCF4_22108803_ChIP-Seq_LS180_Human1.18134218
72P53_22387025_ChIP-Seq_ESCs_Mouse1.15946467
73* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15621106
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13906314
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13100543
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.12913493
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10664843
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.10409641
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.10188814
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10063774
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08300355
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.08043667
83TP53_22573176_ChIP-Seq_HFKS_Human1.07714943
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.07711035
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06751193
86SOX2_19829295_ChIP-Seq_ESCs_Human1.05089717
87NANOG_19829295_ChIP-Seq_ESCs_Human1.05089717
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.04904775
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.04827490
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.03787353
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.03547983
92AHR_22903824_ChIP-Seq_MCF-7_Human1.03456518
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03177184
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02996613
95CDX2_22108803_ChIP-Seq_LS180_Human1.02911511
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01781706
97* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01337535
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.01106887
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.99439612
100KDM2B_26808549_Chip-Seq_REH_Human0.99296726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.76907409
2MP0008877_abnormal_DNA_methylation2.63476944
3MP0005646_abnormal_pituitary_gland2.44749654
4MP0003880_abnormal_central_pattern2.28274391
5MP0005551_abnormal_eye_electrophysiolog2.16018207
6MP0002837_dystrophic_cardiac_calcinosis2.15513485
7MP0002638_abnormal_pupillary_reflex2.01674232
8MP0001986_abnormal_taste_sensitivity1.98167586
9MP0003195_calcinosis1.93101661
10MP0003011_delayed_dark_adaptation1.92862323
11MP0001968_abnormal_touch/_nociception1.90605953
12MP0006276_abnormal_autonomic_nervous1.88112869
13MP0002876_abnormal_thyroid_physiology1.87637999
14MP0009745_abnormal_behavioral_response1.82886476
15MP0001486_abnormal_startle_reflex1.79947366
16MP0001984_abnormal_olfaction1.79438891
17MP0004145_abnormal_muscle_electrophysio1.78385015
18MP0006072_abnormal_retinal_apoptosis1.73119786
19MP0005423_abnormal_somatic_nervous1.70283352
20MP0009046_muscle_twitch1.68752064
21MP0005253_abnormal_eye_physiology1.67940569
22MP0003121_genomic_imprinting1.67524918
23MP0002928_abnormal_bile_duct1.65815547
24MP0001501_abnormal_sleep_pattern1.64880383
25MP0004142_abnormal_muscle_tone1.64398557
26MP0004885_abnormal_endolymph1.64169574
27MP0002557_abnormal_social/conspecific_i1.63433624
28MP0000569_abnormal_digit_pigmentation1.60376564
29MP0002272_abnormal_nervous_system1.59589605
30MP0002653_abnormal_ependyma_morphology1.57943065
31MP0002572_abnormal_emotion/affect_behav1.57508859
32MP0002163_abnormal_gland_morphology1.55834029
33MP0006292_abnormal_olfactory_placode1.54928369
34MP0000631_abnormal_neuroendocrine_gland1.52311756
35MP0005379_endocrine/exocrine_gland_phen1.52288518
36MP0002909_abnormal_adrenal_gland1.50117072
37MP0002822_catalepsy1.47482475
38MP0001970_abnormal_pain_threshold1.47211865
39MP0008872_abnormal_physiological_respon1.47008696
40MP0002102_abnormal_ear_morphology1.45213626
41MP0000427_abnormal_hair_cycle1.45147472
42MP0001485_abnormal_pinna_reflex1.39346484
43MP0000778_abnormal_nervous_system1.38856282
44MP0004043_abnormal_pH_regulation1.37834309
45MP0010386_abnormal_urinary_bladder1.36723563
46MP0005645_abnormal_hypothalamus_physiol1.34878897
47MP0002063_abnormal_learning/memory/cond1.33374181
48MP0003635_abnormal_synaptic_transmissio1.32390933
49MP0002064_seizures1.31976573
50MP0003123_paternal_imprinting1.30674690
51MP0003122_maternal_imprinting1.27849739
52MP0005386_behavior/neurological_phenoty1.25147090
53MP0004924_abnormal_behavior1.25147090
54MP0004133_heterotaxia1.24305789
55MP0008995_early_reproductive_senescence1.23590819
56MP0002734_abnormal_mechanical_nocicepti1.22622042
57MP0002733_abnormal_thermal_nociception1.22251494
58MP0003890_abnormal_embryonic-extraembry1.20813130
59MP0000639_abnormal_adrenal_gland1.16795644
60MP0002067_abnormal_sensory_capabilities1.16114323
61MP0002160_abnormal_reproductive_system1.15747739
62MP0005075_abnormal_melanosome_morpholog1.10290239
63MP0005174_abnormal_tail_pigmentation1.08857231
64MP0000230_abnormal_systemic_arterial1.07909723
65MP0000383_abnormal_hair_follicle1.06968241
66MP0002735_abnormal_chemical_nociception1.05955015
67MP0002938_white_spotting1.05696889
68MP0003646_muscle_fatigue1.04778159
69MP0003136_yellow_coat_color1.04004722
70MP0002736_abnormal_nociception_after1.03979937
71MP0001502_abnormal_circadian_rhythm1.02616931
72MP0001440_abnormal_grooming_behavior1.01788492
73MP0002752_abnormal_somatic_nervous1.01423790
74MP0002184_abnormal_innervation1.00741244
75MP0004742_abnormal_vestibular_system0.99649993
76MP0005389_reproductive_system_phenotype0.96921597
77MP0008775_abnormal_heart_ventricle0.95731519
78MP0000538_abnormal_urinary_bladder0.95706082
79MP0000372_irregular_coat_pigmentation0.92698001
80MP0001944_abnormal_pancreas_morphology0.92376696
81MP0004085_abnormal_heartbeat0.92296413
82MP0004147_increased_porphyrin_level0.92022543
83MP0001529_abnormal_vocalization0.91970660
84MP0002882_abnormal_neuron_morphology0.91929022
85MP0009780_abnormal_chondrocyte_physiolo0.91667987
86MP0004215_abnormal_myocardial_fiber0.91415236
87MP0002234_abnormal_pharynx_morphology0.91232160
88MP0005084_abnormal_gallbladder_morpholo0.91029264
89MP0002229_neurodegeneration0.90619715
90MP0010329_abnormal_lipoprotein_level0.88767601
91MP0001188_hyperpigmentation0.88220062
92MP0003633_abnormal_nervous_system0.86329292
93MP0005195_abnormal_posterior_eye0.85658047
94MP0005448_abnormal_energy_balance0.85575918
95MP0001905_abnormal_dopamine_level0.84197950
96MP0001963_abnormal_hearing_physiology0.83663492
97MP0000026_abnormal_inner_ear0.83528545
98MP0004019_abnormal_vitamin_homeostasis0.83403578
99MP0001756_abnormal_urination0.81278585
100MP0000955_abnormal_spinal_cord0.80347441

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.30487849
2Nephronophthisis (HP:0000090)3.93838620
3Pancreatic fibrosis (HP:0100732)3.91326059
4Abnormality of midbrain morphology (HP:0002418)3.72528732
5Molar tooth sign on MRI (HP:0002419)3.72528732
6Progressive cerebellar ataxia (HP:0002073)3.69988194
7True hermaphroditism (HP:0010459)3.68499378
8Abnormality of the renal medulla (HP:0100957)3.68072407
9Hyperventilation (HP:0002883)3.59099566
10Medial flaring of the eyebrow (HP:0010747)3.56811004
11Chronic hepatic failure (HP:0100626)3.33347203
12Genetic anticipation (HP:0003743)3.29778551
13Gait imbalance (HP:0002141)3.20368384
14Congenital primary aphakia (HP:0007707)3.07383908
15Cystic liver disease (HP:0006706)3.06054645
16Nephrogenic diabetes insipidus (HP:0009806)2.99328083
17Gaze-evoked nystagmus (HP:0000640)2.93140240
18Abnormality of the renal cortex (HP:0011035)2.90455529
19Genital tract atresia (HP:0001827)2.83702362
20Vaginal atresia (HP:0000148)2.72378133
21Decreased central vision (HP:0007663)2.70697792
22Congenital stationary night blindness (HP:0007642)2.69139093
23Protruding tongue (HP:0010808)2.67478850
24Attenuation of retinal blood vessels (HP:0007843)2.56873511
25Poor coordination (HP:0002370)2.50317533
26Absent speech (HP:0001344)2.47288288
27Tubular atrophy (HP:0000092)2.46531914
28Febrile seizures (HP:0002373)2.39948223
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.39941155
30Absent/shortened dynein arms (HP:0200106)2.39941155
31Hemiparesis (HP:0001269)2.38741059
32Type II lissencephaly (HP:0007260)2.38223801
33Abnormal rod and cone electroretinograms (HP:0008323)2.33493864
34Abnormal respiratory epithelium morphology (HP:0012253)2.29290338
35Abnormal respiratory motile cilium morphology (HP:0005938)2.29290338
36Furrowed tongue (HP:0000221)2.24548148
37Tubulointerstitial nephritis (HP:0001970)2.23414825
38Decreased circulating renin level (HP:0003351)2.22023526
39Polydipsia (HP:0001959)2.20954892
40Abnormal drinking behavior (HP:0030082)2.20954892
41Broad-based gait (HP:0002136)2.19850017
42Metaphyseal dysplasia (HP:0100255)2.19600227
43Abolished electroretinogram (ERG) (HP:0000550)2.19234956
44Drooling (HP:0002307)2.15984678
45Abnormal ciliary motility (HP:0012262)2.14917934
46Abnormal pancreas size (HP:0012094)2.13813706
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13668428
48Congenital hepatic fibrosis (HP:0002612)2.12621938
49Male pseudohermaphroditism (HP:0000037)2.12426274
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.11232207
51Postaxial hand polydactyly (HP:0001162)2.10728080
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.10101198
53Tachypnea (HP:0002789)2.05334295
54Hypoplastic ischia (HP:0003175)2.05159539
55Abnormality of the pubic bones (HP:0003172)2.04474777
56Bony spicule pigmentary retinopathy (HP:0007737)2.04332830
57Postaxial foot polydactyly (HP:0001830)2.02338087
58Focal seizures (HP:0007359)2.01713030
59Large for gestational age (HP:0001520)2.01039215
60Abnormality of macular pigmentation (HP:0008002)2.01035150
61Intestinal atresia (HP:0011100)1.99937024
62Keratoconus (HP:0000563)1.99484920
63Increased corneal curvature (HP:0100692)1.99484920
64Widely spaced teeth (HP:0000687)1.99408295
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.98694666
66Asplenia (HP:0001746)1.98307481
67Excessive salivation (HP:0003781)1.97457806
68Short foot (HP:0001773)1.97425172
69Inability to walk (HP:0002540)1.96308976
70Cerebellar dysplasia (HP:0007033)1.95447666
71Renal cortical cysts (HP:0000803)1.93025241
72Sclerocornea (HP:0000647)1.90995350
73Fair hair (HP:0002286)1.90554088
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90180945
75Agitation (HP:0000713)1.85059795
76Abnormal biliary tract physiology (HP:0012439)1.84532850
77Bile duct proliferation (HP:0001408)1.84532850
78Abnormal respiratory motile cilium physiology (HP:0012261)1.84363957
79Abnormality of the ischium (HP:0003174)1.84348599
80Specific learning disability (HP:0001328)1.84089503
81Stage 5 chronic kidney disease (HP:0003774)1.83314100
82Hypothermia (HP:0002045)1.83045111
83Tubulointerstitial abnormality (HP:0001969)1.82053964
84Hypoplastic iliac wings (HP:0002866)1.81884451
85Clumsiness (HP:0002312)1.79641120
86Papilledema (HP:0001085)1.75284633
87Thyroiditis (HP:0100646)1.74498829
88Thyroid-stimulating hormone excess (HP:0002925)1.73940703
89Aplasia/Hypoplasia of the lens (HP:0008063)1.72461823
90Anencephaly (HP:0002323)1.70936217
91Left ventricular hypertrophy (HP:0001712)1.70489620
92Enlarged kidneys (HP:0000105)1.70015728
93Retinitis pigmentosa (HP:0000510)1.69632986
94Narrow forehead (HP:0000341)1.68421624
95Chorioretinal atrophy (HP:0000533)1.63933615
96Lissencephaly (HP:0001339)1.63121554
97Polyuria (HP:0000103)1.62891561
98Rhinitis (HP:0012384)1.62076346
99Multicystic kidney dysplasia (HP:0000003)1.60527935
100Retinal dysplasia (HP:0007973)1.57462727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.61079021
2BMPR1B2.83161407
3NTRK32.38112789
4GRK12.31677263
5ADRBK22.31104128
6MAPK132.25684259
7INSRR2.18829670
8FGFR22.16284175
9CASK2.14498122
10WNK32.14036439
11AKT32.11986929
12MAP3K42.06320696
13PINK11.96209068
14DAPK21.85614169
15ACVR1B1.80970816
16MAP4K21.72483822
17NUAK11.51018453
18TAOK31.49765656
19TNK21.48398525
20PAK31.45916382
21WNK41.41480529
22MAPK151.38536741
23TXK1.36008529
24STK391.31913026
25TRIM281.30205532
26SGK21.30193600
27MARK11.16026539
28OXSR11.12374693
29MUSK1.11985618
30NLK1.08713561
31PRKCE1.08100164
32TEC1.06099199
33PIK3CA1.05683711
34SGK2231.03448927
35SGK4941.03448927
36PRKD31.02115123
37SIK21.00936019
38PRKCH0.96263609
39ITK0.88875739
40MKNK20.87663244
41MAP2K60.85684203
42ERBB30.84830587
43PRKCG0.84798224
44FLT30.84043286
45DYRK1A0.80245481
46TRPM70.80098672
47MAP2K70.79191902
48TNIK0.78908603
49ADRBK10.78788385
50MAPKAPK50.78643373
51ERBB20.76575723
52PTK2B0.75770626
53STK30.74708884
54KIT0.73908430
55ZAK0.73568311
56MAPKAPK30.73170168
57MAP3K70.72732764
58NTRK20.72395007
59TIE10.71855307
60PRKCQ0.70600341
61MAP2K40.70279705
62BCR0.70227440
63EIF2AK30.64978336
64PNCK0.64734920
65EPHA40.63561838
66STK38L0.62768634
67PRKAA10.60370753
68TGFBR10.57980800
69STK110.56927175
70PLK20.55878602
71PKN10.53808177
72PIK3CG0.52378166
73CAMK10.51894241
74MARK20.51790616
75SGK30.51597862
76FER0.49808699
77DYRK20.49518291
78PRKCZ0.49396623
79PRKD20.49219315
80MAP3K20.47159937
81CAMK2A0.46461919
82PHKG20.45815896
83PHKG10.45815896
84PRKAA20.45354667
85EPHA30.44288050
86SGK10.44099354
87PRKACA0.43791548
88MINK10.43209254
89LCK0.40575918
90BTK0.39787410
91CDK30.39309764
92WNK10.39075789
93PRKG10.38534546
94CDK50.37046563
95CSNK1A10.35704772
96UHMK10.35578593
97OBSCN0.32936493
98CSNK1D0.32648604
99RPS6KA20.32599972
100STK240.32488448

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.82063676
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40609295
3Butanoate metabolism_Homo sapiens_hsa006502.35142289
4Nicotine addiction_Homo sapiens_hsa050332.23141716
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21676070
6Linoleic acid metabolism_Homo sapiens_hsa005912.18754693
7Insulin secretion_Homo sapiens_hsa049111.92054670
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.90261259
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84857322
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83362303
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81728318
12Morphine addiction_Homo sapiens_hsa050321.77923896
13Circadian entrainment_Homo sapiens_hsa047131.74779423
14Glutamatergic synapse_Homo sapiens_hsa047241.73346774
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73116693
16ABC transporters_Homo sapiens_hsa020101.69617063
17Taste transduction_Homo sapiens_hsa047421.65449629
18Ether lipid metabolism_Homo sapiens_hsa005651.65181791
19Nitrogen metabolism_Homo sapiens_hsa009101.60789110
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57109033
21GABAergic synapse_Homo sapiens_hsa047271.56401190
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49787755
23Olfactory transduction_Homo sapiens_hsa047401.48477163
24Selenocompound metabolism_Homo sapiens_hsa004501.47147717
25Serotonergic synapse_Homo sapiens_hsa047261.45751978
26Tryptophan metabolism_Homo sapiens_hsa003801.43808589
27Dorso-ventral axis formation_Homo sapiens_hsa043201.42019917
28Dopaminergic synapse_Homo sapiens_hsa047281.40094423
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35963051
30Long-term depression_Homo sapiens_hsa047301.24804810
31Ovarian steroidogenesis_Homo sapiens_hsa049131.23954216
32Renin secretion_Homo sapiens_hsa049241.21557234
33Cholinergic synapse_Homo sapiens_hsa047251.21305128
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19390241
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19297805
36Regulation of autophagy_Homo sapiens_hsa041401.19054591
37Glycerolipid metabolism_Homo sapiens_hsa005611.18957041
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.18160677
39Calcium signaling pathway_Homo sapiens_hsa040201.12108679
40Amphetamine addiction_Homo sapiens_hsa050311.10266845
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.08959753
42Cocaine addiction_Homo sapiens_hsa050301.05956882
43Propanoate metabolism_Homo sapiens_hsa006401.01763580
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01369677
45Salivary secretion_Homo sapiens_hsa049701.01199581
46Peroxisome_Homo sapiens_hsa041460.97922405
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.95561216
48Caffeine metabolism_Homo sapiens_hsa002320.95491285
49cAMP signaling pathway_Homo sapiens_hsa040240.94203694
50Chemical carcinogenesis_Homo sapiens_hsa052040.93254420
51Retinol metabolism_Homo sapiens_hsa008300.92746618
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.92733610
53Fanconi anemia pathway_Homo sapiens_hsa034600.89606849
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88434981
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84919105
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80424301
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79012730
58Homologous recombination_Homo sapiens_hsa034400.78294879
59Oxytocin signaling pathway_Homo sapiens_hsa049210.75879023
60Gastric acid secretion_Homo sapiens_hsa049710.75800104
61Arachidonic acid metabolism_Homo sapiens_hsa005900.74617239
62Circadian rhythm_Homo sapiens_hsa047100.73941258
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.73299115
64Steroid biosynthesis_Homo sapiens_hsa001000.72820716
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72493815
66Basal transcription factors_Homo sapiens_hsa030220.71870798
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71245965
68Collecting duct acid secretion_Homo sapiens_hsa049660.69496106
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69390655
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65705738
71Protein export_Homo sapiens_hsa030600.65524532
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62849179
73Sphingolipid metabolism_Homo sapiens_hsa006000.62207211
74Axon guidance_Homo sapiens_hsa043600.61620119
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59751424
76Vitamin digestion and absorption_Homo sapiens_hsa049770.59665929
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58420841
78Type II diabetes mellitus_Homo sapiens_hsa049300.56815964
79Choline metabolism in cancer_Homo sapiens_hsa052310.55813020
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54422154
81Ras signaling pathway_Homo sapiens_hsa040140.52351008
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52071527
83Lysine degradation_Homo sapiens_hsa003100.51561648
84Histidine metabolism_Homo sapiens_hsa003400.51367573
85Type I diabetes mellitus_Homo sapiens_hsa049400.50463361
86Fat digestion and absorption_Homo sapiens_hsa049750.50325276
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48671339
88Pancreatic secretion_Homo sapiens_hsa049720.46850380
89RNA degradation_Homo sapiens_hsa030180.46445596
90Hedgehog signaling pathway_Homo sapiens_hsa043400.45674218
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44787487
92Inositol phosphate metabolism_Homo sapiens_hsa005620.42257607
93Thyroid hormone synthesis_Homo sapiens_hsa049180.41345705
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40463375
95Oxidative phosphorylation_Homo sapiens_hsa001900.38298004
96beta-Alanine metabolism_Homo sapiens_hsa004100.37384508
97MAPK signaling pathway_Homo sapiens_hsa040100.36529856
98Synaptic vesicle cycle_Homo sapiens_hsa047210.35123287
99Bile secretion_Homo sapiens_hsa049760.34371515
100Cardiac muscle contraction_Homo sapiens_hsa042600.32991064

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