ZNF816

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine-containing compound transmembrane transport (GO:0072531)5.69304727
2rRNA catabolic process (GO:0016075)4.77061912
3kinetochore assembly (GO:0051382)4.64783106
4platelet dense granule organization (GO:0060155)3.93578718
5regulation of mitotic spindle checkpoint (GO:1903504)3.90460931
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.90460931
7kinetochore organization (GO:0051383)3.89498013
8replication fork processing (GO:0031297)3.87999679
9DNA deamination (GO:0045006)3.81052342
10reciprocal DNA recombination (GO:0035825)3.66430585
11reciprocal meiotic recombination (GO:0007131)3.66430585
12RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.60147706
13rRNA methylation (GO:0031167)3.46097594
14positive regulation of histone H3-K4 methylation (GO:0051571)3.45958188
15vitamin transmembrane transport (GO:0035461)3.44489016
16DNA replication checkpoint (GO:0000076)3.42473628
17rRNA modification (GO:0000154)3.34242013
18pseudouridine synthesis (GO:0001522)3.31379171
19histone-serine phosphorylation (GO:0035404)3.24716347
20kynurenine metabolic process (GO:0070189)3.20222093
21nucleoside transmembrane transport (GO:1901642)3.18567235
22respiratory chain complex IV assembly (GO:0008535)3.17798103
23ncRNA catabolic process (GO:0034661)3.13382283
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.12599793
25DNA strand renaturation (GO:0000733)3.10389672
26intra-S DNA damage checkpoint (GO:0031573)3.09246368
27ubiquinone biosynthetic process (GO:0006744)3.09011502
28protein-cofactor linkage (GO:0018065)3.08152313
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07524263
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07099574
31protein K11-linked deubiquitination (GO:0035871)3.07037058
32ubiquinone metabolic process (GO:0006743)3.06128875
33L-fucose metabolic process (GO:0042354)3.05316586
34L-fucose catabolic process (GO:0042355)3.05316586
35fucose catabolic process (GO:0019317)3.05316586
36interleukin-6-mediated signaling pathway (GO:0070102)3.03088847
37regulation of centriole replication (GO:0046599)3.02664740
38DNA double-strand break processing (GO:0000729)3.02011689
39cell fate commitment involved in formation of primary germ layer (GO:0060795)2.95443674
40neural tube formation (GO:0001841)2.91536501
41organelle disassembly (GO:1903008)2.91056326
42response to pheromone (GO:0019236)2.86896005
43regulation of centrosome cycle (GO:0046605)2.83170455
44mitotic G2/M transition checkpoint (GO:0044818)2.81269125
45double-strand break repair via homologous recombination (GO:0000724)2.80595037
46recombinational repair (GO:0000725)2.79373295
47DNA demethylation (GO:0080111)2.79301186
48regulation of spindle checkpoint (GO:0090231)2.78723260
49DNA methylation involved in gamete generation (GO:0043046)2.77912343
50isotype switching (GO:0045190)2.74112744
51somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74112744
52somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74112744
53keratinocyte development (GO:0003334)2.73339110
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72499806
55piRNA metabolic process (GO:0034587)2.71624784
56protein prenylation (GO:0018342)2.69998632
57prenylation (GO:0097354)2.69998632
58DNA damage induced protein phosphorylation (GO:0006975)2.69160310
59indole-containing compound catabolic process (GO:0042436)2.68711982
60indolalkylamine catabolic process (GO:0046218)2.68711982
61tryptophan catabolic process (GO:0006569)2.68711982
62DNA catabolic process, exonucleolytic (GO:0000738)2.65004220
63spliceosomal snRNP assembly (GO:0000387)2.64972456
64tryptophan metabolic process (GO:0006568)2.64937864
65replicative senescence (GO:0090399)2.64051359
66regulation of gene expression by genetic imprinting (GO:0006349)2.63729400
67positive regulation of oligodendrocyte differentiation (GO:0048714)2.63430081
68cytochrome complex assembly (GO:0017004)2.62895486
69purine nucleobase biosynthetic process (GO:0009113)2.62722006
70preassembly of GPI anchor in ER membrane (GO:0016254)2.61288285
71IMP biosynthetic process (GO:0006188)2.60606948
72ribonucleoprotein complex disassembly (GO:0032988)2.59726234
73synapsis (GO:0007129)2.59523509
74chromatin remodeling at centromere (GO:0031055)2.59301769
75histone H3-K4 trimethylation (GO:0080182)2.57829225
76maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.57492202
77behavioral response to nicotine (GO:0035095)2.57249517
78mitochondrial DNA replication (GO:0006264)2.53656882
79adenosine metabolic process (GO:0046085)2.52616562
80negative regulation of cAMP-mediated signaling (GO:0043951)2.51935788
81mannosylation (GO:0097502)2.51163526
82indolalkylamine metabolic process (GO:0006586)2.50542965
83DNA dealkylation (GO:0035510)2.50409588
84water-soluble vitamin biosynthetic process (GO:0042364)2.49200654
85nucleobase biosynthetic process (GO:0046112)2.48125636
86protein polyglutamylation (GO:0018095)2.46389510
87sulfate transmembrane transport (GO:1902358)2.45825341
88tRNA processing (GO:0008033)2.45083974
89nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.43408250
90nucleotide transmembrane transport (GO:1901679)2.41034520
91positive regulation of granulocyte differentiation (GO:0030854)2.40914212
92regulation of meiosis I (GO:0060631)2.40643769
93CENP-A containing nucleosome assembly (GO:0034080)2.39807080
94multicellular organism reproduction (GO:0032504)2.38769140
95protein complex biogenesis (GO:0070271)2.37984102
96negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.37145139
97regulation of acrosome reaction (GO:0060046)2.35896272
98folic acid transport (GO:0015884)2.34537198
99mitochondrial RNA metabolic process (GO:0000959)2.32583284
100magnesium ion transport (GO:0015693)2.31211067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.79957771
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.72818605
3VDR_22108803_ChIP-Seq_LS180_Human3.52980676
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01494378
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.89580039
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.77553096
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62627975
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.62033158
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55325971
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.55042318
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.44228242
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40021983
13ELK1_19687146_ChIP-ChIP_HELA_Human2.31499171
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28297649
15VDR_23849224_ChIP-Seq_CD4+_Human2.24426411
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19492733
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12320306
18IGF1R_20145208_ChIP-Seq_DFB_Human2.11955060
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10001403
20EWS_26573619_Chip-Seq_HEK293_Human2.00520590
21TAF15_26573619_Chip-Seq_HEK293_Human1.96540233
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93128996
23MYC_18940864_ChIP-ChIP_HL60_Human1.83000181
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78943307
25FUS_26573619_Chip-Seq_HEK293_Human1.76912296
26IRF1_19129219_ChIP-ChIP_H3396_Human1.76245739
27E2F7_22180533_ChIP-Seq_HELA_Human1.75450440
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73593155
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73423916
30FOXP3_21729870_ChIP-Seq_TREG_Human1.69280451
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65549696
32P300_19829295_ChIP-Seq_ESCs_Human1.64053338
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59905592
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59588047
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58419195
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56005490
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.54848336
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50693151
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46224324
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44813940
41GBX2_23144817_ChIP-Seq_PC3_Human1.44783455
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44779446
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.44327191
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44327191
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43023598
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42502499
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36761840
48TP53_22573176_ChIP-Seq_HFKS_Human1.35621414
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35433914
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32641811
51ER_23166858_ChIP-Seq_MCF-7_Human1.32182131
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31321922
53CBP_20019798_ChIP-Seq_JUKART_Human1.29483833
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29483833
55GATA3_26560356_Chip-Seq_TH2_Human1.27857938
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27672249
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27404868
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.26262949
59BCAT_22108803_ChIP-Seq_LS180_Human1.26167779
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25727712
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25238850
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23662719
63NANOG_19829295_ChIP-Seq_ESCs_Human1.22276705
64SOX2_19829295_ChIP-Seq_ESCs_Human1.22276705
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.20934705
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.20812443
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19953583
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19641304
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.18512927
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16366038
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.15534709
72TCF4_22108803_ChIP-Seq_LS180_Human1.15193279
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15119453
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14208099
75AR_20517297_ChIP-Seq_VCAP_Human1.13188010
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08043973
77CDX2_22108803_ChIP-Seq_LS180_Human1.05633909
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.05316240
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03621171
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03516110
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03083214
82TCF4_23295773_ChIP-Seq_U87_Human1.02189215
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01191007
84STAT3_23295773_ChIP-Seq_U87_Human0.99234557
85HOXB7_26014856_ChIP-Seq_BT474_Human0.98534092
86RUNX2_22187159_ChIP-Seq_PCA_Human0.98528952
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98284280
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95995750
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95911043
90NCOR_22424771_ChIP-Seq_293T_Human0.95341973
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94502165
92E2F1_21310950_ChIP-Seq_MCF-7_Human0.91292788
93SMAD4_21799915_ChIP-Seq_A2780_Human0.91227758
94GATA1_22025678_ChIP-Seq_K562_Human0.90899314
95MYB_26560356_Chip-Seq_TH2_Human0.90596337
96FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89224612
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.89062366
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88457005
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.87803632
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85443198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.19755690
2MP0003693_abnormal_embryo_hatching3.76415390
3MP0002102_abnormal_ear_morphology3.06744391
4MP0010094_abnormal_chromosome_stability2.63593285
5MP0000383_abnormal_hair_follicle2.47227168
6MP0006072_abnormal_retinal_apoptosis2.42135770
7MP0003195_calcinosis2.21877553
8MP0003806_abnormal_nucleotide_metabolis2.17856865
9MP0006292_abnormal_olfactory_placode2.16180328
10MP0008057_abnormal_DNA_replication2.11301126
11MP0003787_abnormal_imprinting2.10897246
12MP0002277_abnormal_respiratory_mucosa2.00285356
13MP0000372_irregular_coat_pigmentation1.99874011
14MP0005671_abnormal_response_to1.94406176
15MP0000569_abnormal_digit_pigmentation1.94231845
16MP0008058_abnormal_DNA_repair1.91847339
17MP0010678_abnormal_skin_adnexa1.87569159
18MP0001346_abnormal_lacrimal_gland1.78385666
19MP0005389_reproductive_system_phenotype1.72936103
20MP0000647_abnormal_sebaceous_gland1.72917092
21MP0005075_abnormal_melanosome_morpholog1.72242561
22MP0005551_abnormal_eye_electrophysiolog1.71849275
23MP0000427_abnormal_hair_cycle1.71749302
24MP0008875_abnormal_xenobiotic_pharmacok1.71388131
25MP0002138_abnormal_hepatobiliary_system1.71294940
26MP0001764_abnormal_homeostasis1.69806427
27MP0002160_abnormal_reproductive_system1.55702739
28MP0002163_abnormal_gland_morphology1.54839420
29MP0002837_dystrophic_cardiac_calcinosis1.54027559
30MP0005253_abnormal_eye_physiology1.51211448
31MP0003880_abnormal_central_pattern1.44577137
32MP0008872_abnormal_physiological_respon1.43222268
33MP0005360_urolithiasis1.42436460
34MP0003567_abnormal_fetal_cardiomyocyte1.40839724
35MP0003718_maternal_effect1.39235288
36MP0006054_spinal_hemorrhage1.38899119
37MP0005645_abnormal_hypothalamus_physiol1.34801452
38MP0008775_abnormal_heart_ventricle1.34798595
39MP0009697_abnormal_copulation1.34312697
40MP0003111_abnormal_nucleus_morphology1.33152596
41MP0001986_abnormal_taste_sensitivity1.24778759
42MP0006276_abnormal_autonomic_nervous1.24008303
43MP0001919_abnormal_reproductive_system1.23896961
44MP0005379_endocrine/exocrine_gland_phen1.23671669
45MP0002751_abnormal_autonomic_nervous1.22808344
46MP0004147_increased_porphyrin_level1.20490050
47MP0003878_abnormal_ear_physiology1.20357587
48MP0005377_hearing/vestibular/ear_phenot1.20357587
49MP0003077_abnormal_cell_cycle1.18141435
50MP0001929_abnormal_gametogenesis1.17331185
51MP0004957_abnormal_blastocyst_morpholog1.16555510
52MP0002653_abnormal_ependyma_morphology1.15460466
53MP0003252_abnormal_bile_duct1.14990035
54MP0003943_abnormal_hepatobiliary_system1.11265291
55MP0001835_abnormal_antigen_presentation1.09088166
56MP0005084_abnormal_gallbladder_morpholo1.05661960
57MP0002234_abnormal_pharynx_morphology1.02932584
58MP0004133_heterotaxia1.02931802
59MP0003763_abnormal_thymus_physiology1.02417948
60MP0006082_CNS_inflammation1.01118796
61MP0001293_anophthalmia1.00413418
62MP0002210_abnormal_sex_determination0.98014427
63MP0006036_abnormal_mitochondrial_physio0.96566750
64MP0008789_abnormal_olfactory_epithelium0.96074466
65MP0002938_white_spotting0.95794327
66MP0004043_abnormal_pH_regulation0.94996869
67MP0009780_abnormal_chondrocyte_physiolo0.94924243
68MP0002095_abnormal_skin_pigmentation0.93419018
69MP0001968_abnormal_touch/_nociception0.93408594
70MP0008007_abnormal_cellular_replicative0.93075977
71MP0003786_premature_aging0.88669564
72MP0000653_abnormal_sex_gland0.88419050
73MP0005410_abnormal_fertilization0.88408449
74MP0003724_increased_susceptibility_to0.86963369
75MP0001800_abnormal_humoral_immune0.86072587
76MP0001145_abnormal_male_reproductive0.85582639
77MP0009764_decreased_sensitivity_to0.85089525
78MP0005174_abnormal_tail_pigmentation0.84978171
79MP0000689_abnormal_spleen_morphology0.83314732
80MP0004142_abnormal_muscle_tone0.83285692
81MP0002638_abnormal_pupillary_reflex0.82279390
82MP0010386_abnormal_urinary_bladder0.82140249
83MP0003950_abnormal_plasma_membrane0.80215649
84MP0003646_muscle_fatigue0.78660589
85MP0005636_abnormal_mineral_homeostasis0.77561057
86MP0004084_abnormal_cardiac_muscle0.77254579
87MP0001119_abnormal_female_reproductive0.76365848
88MP0002148_abnormal_hypersensitivity_rea0.75712342
89MP0001324_abnormal_eye_pigmentation0.75333614
90MP0001727_abnormal_embryo_implantation0.74802588
91MP0003698_abnormal_male_reproductive0.74504569
92MP0001485_abnormal_pinna_reflex0.73766270
93MP0005195_abnormal_posterior_eye0.72551789
94MP0001819_abnormal_immune_cell0.71945449
95MP0002396_abnormal_hematopoietic_system0.69817167
96MP0002420_abnormal_adaptive_immunity0.69355661
97MP0002452_abnormal_antigen_presenting0.66251150
98MP0002723_abnormal_immune_serum0.65559431
99MP0009333_abnormal_splenocyte_physiolog0.65135341
100MP0000015_abnormal_ear_pigmentation0.64914150

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)3.78053975
2Molar tooth sign on MRI (HP:0002419)3.78053975
3Renal cortical cysts (HP:0000803)3.71677691
4Abnormality of the renal cortex (HP:0011035)3.42436772
5Pancreatic cysts (HP:0001737)3.30518144
6Pancreatic fibrosis (HP:0100732)3.23427539
7True hermaphroditism (HP:0010459)3.07421509
8Nephronophthisis (HP:0000090)3.07219091
9Constricted visual fields (HP:0001133)2.95621696
10Hypomagnesemia (HP:0002917)2.85008103
11Abnormality of the renal medulla (HP:0100957)2.65341925
12IgG deficiency (HP:0004315)2.61139981
13Abnormality of the labia minora (HP:0012880)2.55635713
14Volvulus (HP:0002580)2.51225617
15Cone-rod dystrophy (HP:0000548)2.49689696
16Congenital stationary night blindness (HP:0007642)2.49129457
17Chronic hepatic failure (HP:0100626)2.40492514
18Decreased central vision (HP:0007663)2.38874981
19Cerebellar dysplasia (HP:0007033)2.37213228
20Short tibia (HP:0005736)2.31278693
21Abolished electroretinogram (ERG) (HP:0000550)2.27962428
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.27077902
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25009735
24Lipid accumulation in hepatocytes (HP:0006561)2.21092091
25Stomatitis (HP:0010280)2.19075064
26Abnormality of the pons (HP:0007361)2.18240188
27Recurrent corneal erosions (HP:0000495)2.17727644
28Type 2 muscle fiber atrophy (HP:0003554)2.13379161
29Panhypogammaglobulinemia (HP:0003139)2.13352101
30Attenuation of retinal blood vessels (HP:0007843)2.12888806
31Abnormality of chromosome stability (HP:0003220)2.11251187
32Medial flaring of the eyebrow (HP:0010747)2.11050244
33Sloping forehead (HP:0000340)2.07779570
34Abnormal rod and cone electroretinograms (HP:0008323)2.04882397
35Increased hepatocellular lipid droplets (HP:0006565)2.04734695
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.04382426
37Hypoplasia of the pons (HP:0012110)2.01997455
38Hypoproteinemia (HP:0003075)2.01920874
39Abnormality of B cell number (HP:0010975)2.01196009
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00681174
41Postaxial foot polydactyly (HP:0001830)2.00366956
42Hypoplasia of the uterus (HP:0000013)2.00296565
43Parakeratosis (HP:0001036)2.00066585
44Dry hair (HP:0011359)1.98145467
45Pendular nystagmus (HP:0012043)1.97590494
46Increased CSF lactate (HP:0002490)1.96501979
47Stomach cancer (HP:0012126)1.94209833
48Chromsome breakage (HP:0040012)1.93933393
49Congenital hepatic fibrosis (HP:0002612)1.93681077
50Decreased circulating renin level (HP:0003351)1.91969225
51Abnormal delayed hypersensitivity skin test (HP:0002963)1.90572029
52B lymphocytopenia (HP:0010976)1.90565799
53Progressive inability to walk (HP:0002505)1.89235461
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88961240
55Abnormal protein N-linked glycosylation (HP:0012347)1.88961240
56Abnormal protein glycosylation (HP:0012346)1.88961240
57Abnormal glycosylation (HP:0012345)1.88961240
58Colon cancer (HP:0003003)1.87281137
59Abnormal biliary tract physiology (HP:0012439)1.86779648
60Bile duct proliferation (HP:0001408)1.86779648
61Chronic diarrhea (HP:0002028)1.85817371
62Aplasia/hypoplasia of the uterus (HP:0008684)1.84181514
63Optic disc pallor (HP:0000543)1.83710518
64Oculomotor apraxia (HP:0000657)1.81435097
65Tubular atrophy (HP:0000092)1.81180945
66Aplasia/Hypoplasia of the uvula (HP:0010293)1.80751521
67Abnormality of magnesium homeostasis (HP:0004921)1.80730684
68Glycosuria (HP:0003076)1.80160902
69Abnormality of urine glucose concentration (HP:0011016)1.80160902
70Increased corneal curvature (HP:0100692)1.79893932
71Keratoconus (HP:0000563)1.79893932
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78950846
733-Methylglutaconic aciduria (HP:0003535)1.78387119
74Type I transferrin isoform profile (HP:0003642)1.78172282
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.77119673
76Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76799920
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76799920
78Severe combined immunodeficiency (HP:0004430)1.76392557
79Cystic liver disease (HP:0006706)1.76177482
80Anhidrosis (HP:0000970)1.75995288
81Abnormality of methionine metabolism (HP:0010901)1.75916831
82Hyperglycinemia (HP:0002154)1.75177078
83Increased serum lactate (HP:0002151)1.75038065
84Abnormality of the ileum (HP:0001549)1.73762689
85Type I diabetes mellitus (HP:0100651)1.73645983
86Meckel diverticulum (HP:0002245)1.72955311
87Supernumerary spleens (HP:0009799)1.72128798
88Mitochondrial inheritance (HP:0001427)1.69666234
89Postaxial hand polydactyly (HP:0001162)1.69231678
90Tetany (HP:0001281)1.67411319
91Lissencephaly (HP:0001339)1.67347304
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66655411
93IgM deficiency (HP:0002850)1.64481867
94Congenital, generalized hypertrichosis (HP:0004540)1.64164561
95Abnormality of DNA repair (HP:0003254)1.63089306
96Thyroiditis (HP:0100646)1.62453628
97Type II lissencephaly (HP:0007260)1.62345011
98Poor speech (HP:0002465)1.61985945
99Absent/shortened dynein arms (HP:0200106)1.61840774
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.61840774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K134.55261210
2MAP3K94.22786287
3EIF2AK33.70633236
4ZAK3.67711260
5MAP4K23.00955189
6NUAK12.93559148
7MST42.93339946
8TAF12.81202601
9FRK2.43215582
10BMPR1B2.19191725
11TXK2.12922325
12WNK32.08049369
13MAP3K141.83435488
14VRK11.72212409
15TAOK31.70384063
16ADRBK21.68333138
17GRK11.60141411
18BRSK21.55492245
19TRIM281.55219748
20MUSK1.48210388
21MAP3K41.44379782
22TLK11.43471867
23PLK31.35280157
24TNIK1.32792115
25PASK1.29653598
26VRK21.27504108
27PINK11.25270640
28PLK41.22164178
29BUB11.20714776
30MKNK21.12750762
31CDK191.11389416
32TGFBR11.04654291
33IKBKB1.01810082
34FLT30.99063731
35WNK40.97499140
36MKNK10.97315236
37SRPK10.96841519
38EIF2AK20.96271322
39MATK0.95139642
40PLK10.92644881
41TTK0.91499977
42TSSK60.90848307
43ERBB30.86535159
44ACVR1B0.86167120
45PRKCQ0.82903996
46STK30.82443646
47AKT30.80643202
48IRAK40.79781646
49OXSR10.74898771
50BCKDK0.72263167
51MARK30.72020224
52STK390.71331335
53PLK20.70860860
54PAK30.70172149
55RPS6KA40.67958746
56KIT0.66856486
57INSRR0.66729679
58STK160.66470561
59CAMKK20.63339216
60MAP3K70.62871812
61NME10.59768756
62PRKCE0.56485624
63MAPK130.56264159
64ATR0.55920551
65CDC70.55768992
66ATM0.53539427
67PBK0.50754977
68BMPR20.49285056
69CSNK1G10.47651605
70NTRK20.47591821
71TEC0.46889920
72PIK3CG0.46673197
73AURKB0.44497744
74PIK3CA0.43112337
75MET0.42749932
76CHUK0.42580690
77CHEK20.41948128
78STK38L0.41812949
79ITK0.41397691
80NLK0.41370438
81GRK60.40237238
82CDK90.39773984
83CSNK1G30.38055552
84BTK0.37178679
85KSR10.36497515
86DAPK20.35658277
87MAP2K70.35625294
88NEK20.35418003
89PRKCI0.35106413
90EPHA30.34933751
91BCR0.34177172
92WEE10.34062635
93PIM10.33888355
94SYK0.32685197
95MAP4K10.32679799
96CSNK2A20.31272994
97CDK80.31225178
98CSNK1G20.30148616
99LATS10.30121593
100IKBKE0.28660337

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.00534854
2Basal transcription factors_Homo sapiens_hsa030222.93325631
3Homologous recombination_Homo sapiens_hsa034402.86666174
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.78107681
5One carbon pool by folate_Homo sapiens_hsa006702.53968252
6RNA degradation_Homo sapiens_hsa030182.41522160
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36557398
8RNA polymerase_Homo sapiens_hsa030202.34642448
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22703462
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20391688
11Selenocompound metabolism_Homo sapiens_hsa004502.19034646
12Non-homologous end-joining_Homo sapiens_hsa034502.15478051
13Proteasome_Homo sapiens_hsa030502.15063905
14Primary immunodeficiency_Homo sapiens_hsa053402.10693070
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95106815
16Fanconi anemia pathway_Homo sapiens_hsa034601.90331589
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88521949
18Phototransduction_Homo sapiens_hsa047441.86900849
19RNA transport_Homo sapiens_hsa030131.76023611
20Nitrogen metabolism_Homo sapiens_hsa009101.72339123
21Caffeine metabolism_Homo sapiens_hsa002321.70880169
22Propanoate metabolism_Homo sapiens_hsa006401.66951235
23Butanoate metabolism_Homo sapiens_hsa006501.61399926
24Vitamin digestion and absorption_Homo sapiens_hsa049771.58795592
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.57288193
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57268722
27Linoleic acid metabolism_Homo sapiens_hsa005911.47504152
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.42489800
29Tryptophan metabolism_Homo sapiens_hsa003801.40900843
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36601254
31Peroxisome_Homo sapiens_hsa041461.30117020
32Purine metabolism_Homo sapiens_hsa002301.29857121
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.28042739
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25845008
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23345888
36Steroid biosynthesis_Homo sapiens_hsa001001.22059475
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20309951
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20286069
39Pyrimidine metabolism_Homo sapiens_hsa002401.19548929
40Mismatch repair_Homo sapiens_hsa034301.18390122
41Nucleotide excision repair_Homo sapiens_hsa034201.18059981
42Spliceosome_Homo sapiens_hsa030401.14485067
43Protein export_Homo sapiens_hsa030601.14154594
44Oxidative phosphorylation_Homo sapiens_hsa001901.13170936
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12333281
46Ribosome_Homo sapiens_hsa030101.07666040
47Regulation of autophagy_Homo sapiens_hsa041401.06729861
48Graft-versus-host disease_Homo sapiens_hsa053321.05647139
49Ether lipid metabolism_Homo sapiens_hsa005650.97500339
50Allograft rejection_Homo sapiens_hsa053300.95359967
51Taste transduction_Homo sapiens_hsa047420.91871980
52Sulfur metabolism_Homo sapiens_hsa009200.91752734
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91094912
54p53 signaling pathway_Homo sapiens_hsa041150.90514475
55Fatty acid elongation_Homo sapiens_hsa000620.80988981
56Base excision repair_Homo sapiens_hsa034100.79518023
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78476066
58Cell cycle_Homo sapiens_hsa041100.77685711
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75875418
60Circadian rhythm_Homo sapiens_hsa047100.74549892
61Autoimmune thyroid disease_Homo sapiens_hsa053200.74106056
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72245480
63Parkinsons disease_Homo sapiens_hsa050120.71914958
64Chemical carcinogenesis_Homo sapiens_hsa052040.70518113
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68395566
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68313733
67Huntingtons disease_Homo sapiens_hsa050160.67434383
68Type I diabetes mellitus_Homo sapiens_hsa049400.65492168
69Olfactory transduction_Homo sapiens_hsa047400.64158616
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63221012
71DNA replication_Homo sapiens_hsa030300.62959587
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.61346011
73Glutathione metabolism_Homo sapiens_hsa004800.59509295
74Mineral absorption_Homo sapiens_hsa049780.55177147
75Metabolic pathways_Homo sapiens_hsa011000.54150833
76Antigen processing and presentation_Homo sapiens_hsa046120.54042219
77Oocyte meiosis_Homo sapiens_hsa041140.52830477
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.52539255
79mRNA surveillance pathway_Homo sapiens_hsa030150.51756029
80Retinol metabolism_Homo sapiens_hsa008300.51609202
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50777469
82T cell receptor signaling pathway_Homo sapiens_hsa046600.50492521
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50320224
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46962477
85Arachidonic acid metabolism_Homo sapiens_hsa005900.46376752
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45553196
87N-Glycan biosynthesis_Homo sapiens_hsa005100.44779970
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43601886
89Asthma_Homo sapiens_hsa053100.43183650
90ABC transporters_Homo sapiens_hsa020100.41316559
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40622263
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39809913
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39800094
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38866104
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.38798290
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37260669
97Herpes simplex infection_Homo sapiens_hsa051680.33778414
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33052879
99Measles_Homo sapiens_hsa051620.31217767
100Hematopoietic cell lineage_Homo sapiens_hsa046400.30802905

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