ZNF815P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.41322148
2negative regulation of cell killing (GO:0031342)6.32385748
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.32385748
4negative T cell selection (GO:0043383)6.18319860
5negative thymic T cell selection (GO:0045060)5.85239510
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.76063363
7positive regulation of granulocyte differentiation (GO:0030854)5.35570627
8activated T cell proliferation (GO:0050798)5.32634769
9positive T cell selection (GO:0043368)5.04142029
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.99173151
11regulation of B cell receptor signaling pathway (GO:0050855)4.88810318
12regulation of gamma-delta T cell differentiation (GO:0045586)4.88599920
13tolerance induction (GO:0002507)4.76287977
14regulation of gamma-delta T cell activation (GO:0046643)4.67374940
15T cell selection (GO:0045058)4.66721471
16leukocyte aggregation (GO:0070486)4.64347995
17response to interleukin-15 (GO:0070672)4.49553556
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.41091463
19negative regulation of T cell mediated immunity (GO:0002710)4.37836886
20positive thymic T cell selection (GO:0045059)4.28644208
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18719811
22cellular response to interleukin-15 (GO:0071350)4.18137151
23thymic T cell selection (GO:0045061)4.14066532
24T cell migration (GO:0072678)3.98046797
25antigen processing and presentation of endogenous antigen (GO:0019883)3.89439187
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.74380204
27regulation of isotype switching to IgG isotypes (GO:0048302)3.61471751
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60449343
29regulation of granulocyte differentiation (GO:0030852)3.51413356
30positive regulation of B cell differentiation (GO:0045579)3.50558449
31modulation by symbiont of host defense response (GO:0052031)3.48933505
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48933505
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48933505
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.48933505
35modulation by symbiont of host immune response (GO:0052553)3.48933505
36positive regulation by symbiont of host defense response (GO:0052509)3.48933505
37negative regulation of cAMP-mediated signaling (GO:0043951)3.48038180
38regulation of regulatory T cell differentiation (GO:0045589)3.47102217
39regulation of T cell tolerance induction (GO:0002664)3.47095249
40regulation of interleukin-2 biosynthetic process (GO:0045076)3.32381040
41regulation of alpha-beta T cell proliferation (GO:0046640)3.31535002
42T cell receptor signaling pathway (GO:0050852)3.31058289
43negative regulation of leukocyte mediated immunity (GO:0002704)3.26988770
44positive regulation of humoral immune response (GO:0002922)3.22246001
45interferon-gamma production (GO:0032609)3.20874465
46T cell homeostasis (GO:0043029)3.18486691
47regulation of defense response to virus by virus (GO:0050690)3.17221126
48antigen receptor-mediated signaling pathway (GO:0050851)3.16170428
49regulation of B cell differentiation (GO:0045577)3.14563573
50B cell receptor signaling pathway (GO:0050853)3.13459980
51alpha-beta T cell differentiation (GO:0046632)3.09053243
52positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03812372
53negative regulation of interleukin-12 production (GO:0032695)3.02325258
54regulation of tolerance induction (GO:0002643)2.96604683
55myeloid dendritic cell activation (GO:0001773)2.96452266
56alpha-beta T cell activation (GO:0046631)2.95710988
57positive regulation of tolerance induction (GO:0002645)2.95239973
58positive regulation of mast cell activation (GO:0033005)2.94354617
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91707822
60mast cell activation (GO:0045576)2.88398588
61regulation of natural killer cell mediated immunity (GO:0002715)2.86572704
62regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86572704
63natural killer cell differentiation (GO:0001779)2.85431205
64regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85394733
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83215094
66positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.83181397
67negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.82531674
68negative regulation of type 2 immune response (GO:0002829)2.81919214
69NIK/NF-kappaB signaling (GO:0038061)2.80732973
70pyrimidine nucleobase catabolic process (GO:0006208)2.80100535
71protein targeting to Golgi (GO:0000042)2.79911975
72establishment of protein localization to Golgi (GO:0072600)2.77311704
73neutrophil activation involved in immune response (GO:0002283)2.77015542
74phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.75834540
75cellular extravasation (GO:0045123)2.75438446
76respiratory burst (GO:0045730)2.75319131
77negative regulation of glycoprotein biosynthetic process (GO:0010561)2.73217845
78regulation of isotype switching (GO:0045191)2.72990939
79positive regulation of T cell differentiation in thymus (GO:0033089)2.72590100
80signal complex assembly (GO:0007172)2.70775458
81regulation of T cell mediated cytotoxicity (GO:0001914)2.67954276
82regulation of interleukin-4 production (GO:0032673)2.66033511
83neutrophil activation (GO:0042119)2.65374148
84T cell differentiation (GO:0030217)2.64722157
85positive regulation of isotype switching (GO:0045830)2.62701360
86positive regulation of interleukin-4 production (GO:0032753)2.62162162
87regulation of MHC class I biosynthetic process (GO:0045343)2.61963271
88positive regulation of interleukin-2 production (GO:0032743)2.61550990
89myeloid leukocyte mediated immunity (GO:0002444)2.60141323
90macrophage activation involved in immune response (GO:0002281)2.59781404
91myeloid dendritic cell differentiation (GO:0043011)2.59357625
92single strand break repair (GO:0000012)2.58491911
93T cell proliferation (GO:0042098)2.57997997
94response to muramyl dipeptide (GO:0032495)2.56872611
95negative regulation of erythrocyte differentiation (GO:0045647)2.56288638
96histone H3-K36 demethylation (GO:0070544)2.55938687
97myeloid cell activation involved in immune response (GO:0002275)2.55813294
98negative regulation of adaptive immune response (GO:0002820)2.55703602
99retrograde transport, vesicle recycling within Golgi (GO:0000301)2.52686100
100necrotic cell death (GO:0070265)2.51437097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.74232075
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.86513468
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.05118513
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.84110711
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.52022705
6RUNX_20019798_ChIP-Seq_JUKART_Human3.51918240
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.47952348
8MYB_26560356_Chip-Seq_TH2_Human3.09674833
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.83964638
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74798318
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68398496
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64555317
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50102443
14MYB_26560356_Chip-Seq_TH1_Human2.48999365
15SCL_19346495_ChIP-Seq_HPC-7_Human2.34349130
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34189304
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33949831
18MAF_26560356_Chip-Seq_TH1_Human2.32694605
19MYC_22102868_ChIP-Seq_BL_Human2.32425346
20UTX_26944678_Chip-Seq_JUKART_Human2.29979693
21CIITA_25753668_ChIP-Seq_RAJI_Human2.28076185
22SPI1_23547873_ChIP-Seq_NB4_Human2.24849848
23MAF_26560356_Chip-Seq_TH2_Human2.23101127
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19454962
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.15688758
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.15581856
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10016489
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06292867
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.06260568
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99465939
31GATA3_27048872_Chip-Seq_THYMUS_Human1.98850297
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97983823
33VDR_21846776_ChIP-Seq_THP-1_Human1.96784435
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95670557
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94948038
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.93256828
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91795248
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88814754
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83472147
40VDR_23849224_ChIP-Seq_CD4+_Human1.81989166
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81690131
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.78144571
43GATA3_26560356_Chip-Seq_TH2_Human1.57019331
44TCF7_22412390_ChIP-Seq_EML_Mouse1.55594432
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54895648
46SPI1_23127762_ChIP-Seq_K562_Human1.53812171
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.50293297
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45559458
49VDR_24763502_ChIP-Seq_THP-1_Human1.41953979
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38205495
51FOXP3_21729870_ChIP-Seq_TREG_Human1.37627659
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37330023
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37098962
54KDM2B_26808549_Chip-Seq_DND41_Human1.34624433
55FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30813123
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23545197
57PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21309663
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19279031
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14659696
60ZNF274_21170338_ChIP-Seq_K562_Hela1.11804305
61RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11296835
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08802866
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.08082122
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07301119
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06911201
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06676497
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.06333650
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.05056959
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04915863
70TFEB_21752829_ChIP-Seq_HELA_Human0.99010023
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98820037
72GATA3_26560356_Chip-Seq_TH1_Human0.96456404
73PU_27001747_Chip-Seq_BMDM_Mouse0.96451966
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96298102
75VDR_24787735_ChIP-Seq_THP-1_Human0.95879727
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95236554
77HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94517368
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94512758
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93717401
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93092354
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93076434
82BCL6_27268052_Chip-Seq_Bcells_Human0.92881378
83THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92118732
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91916835
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91750552
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90716084
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.88101307
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86314842
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85460683
90IGF1R_20145208_ChIP-Seq_DFB_Human0.84216548
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81335319
92ETS1_20019798_ChIP-Seq_JURKAT_Human0.81303532
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81222330
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81064608
95GABP_17652178_ChIP-ChIP_JURKAT_Human0.80681904
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80368001
97GABP_19822575_ChIP-Seq_HepG2_Human0.79536446
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78823075
99KDM5A_27292631_Chip-Seq_BREAST_Human0.78802256
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78454350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.37629253
2MP0003436_decreased_susceptibility_to3.16075745
3MP0003724_increased_susceptibility_to3.13682361
4MP0005671_abnormal_response_to2.91883433
5MP0001800_abnormal_humoral_immune2.75418041
6MP0001835_abnormal_antigen_presentation2.75213363
7MP0005000_abnormal_immune_tolerance2.46280863
8MP0002420_abnormal_adaptive_immunity2.43932803
9MP0001819_abnormal_immune_cell2.39739085
10MP0000703_abnormal_thymus_morphology2.32228233
11MP0009333_abnormal_splenocyte_physiolog2.31089527
12MP0002723_abnormal_immune_serum2.30861096
13MP0008260_abnormal_autophagy2.25836524
14MP0002419_abnormal_innate_immunity2.24455532
15MP0002452_abnormal_antigen_presenting2.21918981
16MP0002398_abnormal_bone_marrow2.17947463
17MP0005025_abnormal_response_to2.15643426
18MP0003866_abnormal_defecation2.14640542
19MP0003172_abnormal_lysosome_physiology2.14405151
20MP0001986_abnormal_taste_sensitivity2.04521641
21MP0001790_abnormal_immune_system2.03407458
22MP0005387_immune_system_phenotype2.03407458
23MP0000716_abnormal_immune_system1.99342450
24MP0000685_abnormal_immune_system1.96997353
25MP0000689_abnormal_spleen_morphology1.93182594
26MP0004381_abnormal_hair_follicle1.92369160
27MP0009785_altered_susceptibility_to1.92108030
28MP0005075_abnormal_melanosome_morpholog1.90449045
29MP0001873_stomach_inflammation1.88380338
30MP0002722_abnormal_immune_system1.86721743
31MP0000465_gastrointestinal_hemorrhage1.83759571
32MP0003300_gastrointestinal_ulcer1.80365440
33MP0003303_peritoneal_inflammation1.80004673
34MP0002148_abnormal_hypersensitivity_rea1.78183078
35MP0006082_CNS_inflammation1.74706498
36MP0002405_respiratory_system_inflammati1.72072173
37MP0005310_abnormal_salivary_gland1.71818473
38MP0002429_abnormal_blood_cell1.57911752
39MP0002396_abnormal_hematopoietic_system1.57181571
40MP0005464_abnormal_platelet_physiology1.56250196
41MP0001851_eye_inflammation1.46705269
42MP0009278_abnormal_bone_marrow1.44026780
43MP0008995_early_reproductive_senescence1.43819057
44MP0008877_abnormal_DNA_methylation1.39503145
45MP0002009_preneoplasia1.39025402
46MP0001845_abnormal_inflammatory_respons1.31411824
47MP0004947_skin_inflammation1.28247325
48MP0001968_abnormal_touch/_nociception1.27691446
49MP0003787_abnormal_imprinting1.27012694
50MP0006035_abnormal_mitochondrial_morpho1.26773969
51MP0002132_abnormal_respiratory_system1.25587855
52MP0001545_abnormal_hematopoietic_system1.23857605
53MP0005397_hematopoietic_system_phenotyp1.23857605
54MP0008961_abnormal_basal_metabolism1.23802511
55MP0003656_abnormal_erythrocyte_physiolo1.22332562
56MP0010155_abnormal_intestine_physiology1.18107053
57MP0002277_abnormal_respiratory_mucosa1.16203036
58MP0001533_abnormal_skeleton_physiology1.13928728
59MP0000569_abnormal_digit_pigmentation1.10774598
60MP0003329_amyloid_beta_deposits1.09099260
61MP0004859_abnormal_synaptic_plasticity1.08146732
62MP0004510_myositis1.06579081
63MP0000604_amyloidosis1.04687646
64MP0005451_abnormal_body_composition1.03275165
65MP0004130_abnormal_muscle_cell1.02280831
66MP0008569_lethality_at_weaning0.98422669
67MP0008057_abnormal_DNA_replication0.94165560
68MP0004883_abnormal_blood_vessel0.93453224
69MP0003635_abnormal_synaptic_transmissio0.92673505
70MP0003183_abnormal_peptide_metabolism0.90895492
71MP0000490_abnormal_crypts_of0.90834007
72MP0002166_altered_tumor_susceptibility0.88352039
73MP0002138_abnormal_hepatobiliary_system0.87872731
74MP0004142_abnormal_muscle_tone0.86573184
75MP0008469_abnormal_protein_level0.86425512
76MP0004808_abnormal_hematopoietic_stem0.86064240
77MP0003191_abnormal_cellular_cholesterol0.85833396
78MP0001853_heart_inflammation0.83027613
79MP0003221_abnormal_cardiomyocyte_apopto0.81854958
80MP0000858_altered_metastatic_potential0.81337950
81MP0000015_abnormal_ear_pigmentation0.78066102
82MP0002102_abnormal_ear_morphology0.76904867
83MP0002933_joint_inflammation0.73760792
84MP0009745_abnormal_behavioral_response0.71135199
85MP0003690_abnormal_glial_cell0.69961966
86MP0008874_decreased_physiological_sensi0.67701565
87MP0002019_abnormal_tumor_incidence0.67035394
88MP0008873_increased_physiological_sensi0.65244153
89MP0009764_decreased_sensitivity_to0.64207225
90MP0002063_abnormal_learning/memory/cond0.62545756
91MP0002064_seizures0.62233619
92MP0001919_abnormal_reproductive_system0.61379223
93MP0002067_abnormal_sensory_capabilities0.60964412
94MP0002822_catalepsy0.60199873
95MP0004811_abnormal_neuron_physiology0.57125265
96MP0001905_abnormal_dopamine_level0.57116294
97MP0005423_abnormal_somatic_nervous0.57113660
98MP0003786_premature_aging0.56808879
99MP0003880_abnormal_central_pattern0.56347509
100MP0006036_abnormal_mitochondrial_physio0.55763503

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.70580412
2T lymphocytopenia (HP:0005403)5.19987565
3Eczematoid dermatitis (HP:0000976)5.07679266
4Elevated erythrocyte sedimentation rate (HP:0003565)4.85296147
5Abnormality of T cell number (HP:0011839)4.72435570
6Recurrent bacterial skin infections (HP:0005406)4.51793046
7Myositis (HP:0100614)4.35416131
8Recurrent abscess formation (HP:0002722)4.09226994
9Panhypogammaglobulinemia (HP:0003139)4.08622627
10Recurrent fungal infections (HP:0002841)4.05569474
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.04391061
12Abnormality of T cells (HP:0002843)3.93639624
13Pustule (HP:0200039)3.70663705
14Slow saccadic eye movements (HP:0000514)3.56807799
15Chronic mucocutaneous candidiasis (HP:0002728)3.47156837
16Recurrent cutaneous fungal infections (HP:0011370)3.47156837
17Mediastinal lymphadenopathy (HP:0100721)3.41162527
18Abnormality of macrophages (HP:0004311)3.40905841
19Retrobulbar optic neuritis (HP:0100654)3.37098095
20Optic neuritis (HP:0100653)3.37098095
21Severe combined immunodeficiency (HP:0004430)3.25176106
22Orchitis (HP:0100796)3.20512631
23Recurrent skin infections (HP:0001581)3.17488191
24Papilledema (HP:0001085)3.09096474
25Encephalitis (HP:0002383)3.04376194
26IgG deficiency (HP:0004315)3.02750192
27Abnormality of T cell physiology (HP:0011840)2.97294843
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.92810629
29Recurrent viral infections (HP:0004429)2.92490536
30Leukocytosis (HP:0001974)2.80965311
31Prolonged bleeding time (HP:0003010)2.79421521
32Meningitis (HP:0001287)2.79126107
33Genetic anticipation (HP:0003743)2.74899366
34Autoimmune hemolytic anemia (HP:0001890)2.71270060
35Increased IgM level (HP:0003496)2.68331335
36Gastrointestinal inflammation (HP:0004386)2.65375921
37Granulocytopenia (HP:0001913)2.62057181
38Gastrointestinal infarctions (HP:0005244)2.59426995
39Combined immunodeficiency (HP:0005387)2.58563702
40Postural instability (HP:0002172)2.57448153
41Inflammation of the large intestine (HP:0002037)2.55759829
42Chest pain (HP:0100749)2.55380087
43Basal cell carcinoma (HP:0002671)2.55268261
44Abnormality of eosinophils (HP:0001879)2.49247216
45Recurrent gram-negative bacterial infections (HP:0005420)2.47582584
46Obstructive lung disease (HP:0006536)2.45372294
47Chronic obstructive pulmonary disease (HP:0006510)2.45372294
48Gingival bleeding (HP:0000225)2.39961164
49Spontaneous hematomas (HP:0007420)2.38269981
50Gingivitis (HP:0000230)2.36952142
51Hypochromic microcytic anemia (HP:0004840)2.35837161
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.35486454
53Episodic fever (HP:0001954)2.34787983
54Focal motor seizures (HP:0011153)2.33240117
55Keratoconjunctivitis sicca (HP:0001097)2.32628183
56Amyotrophic lateral sclerosis (HP:0007354)2.32220840
57Keratoconjunctivitis (HP:0001096)2.31969676
58Epistaxis (HP:0000421)2.29969616
59Lymphopenia (HP:0001888)2.28863375
60Papilloma (HP:0012740)2.27300388
61Verrucae (HP:0200043)2.27300388
62Vasculitis (HP:0002633)2.24989899
63Eosinophilia (HP:0001880)2.22884651
64Prostate neoplasm (HP:0100787)2.21033907
65Hypochromic anemia (HP:0001931)2.13590845
66Pulmonary infiltrates (HP:0002113)2.12026074
67IgM deficiency (HP:0002850)2.11505712
68Hypoplasia of the thymus (HP:0000778)2.10987159
69Acute hepatic failure (HP:0006554)2.10642831
70Dysmetric saccades (HP:0000641)2.09285390
71Anorexia (HP:0002039)2.09284715
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.06709838
73Cellulitis (HP:0100658)2.03532912
74Fatigue (HP:0012378)2.02002737
75Supranuclear gaze palsy (HP:0000605)2.01657021
76Abnormality of the columella (HP:0009929)1.97033715
77Stomach cancer (HP:0012126)1.96397356
78Urticaria (HP:0001025)1.95244443
79Recurrent bronchitis (HP:0002837)1.93592954
80Thrombocytosis (HP:0001894)1.91968860
81Colitis (HP:0002583)1.90691877
82Neuronal loss in central nervous system (HP:0002529)1.88109990
83Arterial thrombosis (HP:0004420)1.87501796
84Progressive cerebellar ataxia (HP:0002073)1.84191158
85Abnormality of the prostate (HP:0008775)1.83738881
86Loss of speech (HP:0002371)1.81169678
87Hemoptysis (HP:0002105)1.80482990
88Agammaglobulinemia (HP:0004432)1.79178753
89Vertigo (HP:0002321)1.74986750
90Viral hepatitis (HP:0006562)1.74565020
91Ankle clonus (HP:0011448)1.72690868
92Increased IgE level (HP:0003212)1.70562558
93Abnormality of saccadic eye movements (HP:0000570)1.69631383
94IgA deficiency (HP:0002720)1.69508233
95Abnormality of the fingertips (HP:0001211)1.69264235
96Microcytic anemia (HP:0001935)1.68410553
97Joint swelling (HP:0001386)1.67904483
98Poor speech (HP:0002465)1.67708707
99Visual hallucinations (HP:0002367)1.67629849
100Sepsis (HP:0100806)1.66924419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.11833476
2TXK3.61161492
3CAMKK23.28271561
4RIPK43.18307416
5FES2.72419354
6GRK62.66914329
7CDK192.59128790
8CAMKK12.37906367
9PRPF4B2.34849646
10TYK22.15794641
11TAOK32.12984835
12BTK2.02181635
13ITK1.98069092
14PASK1.96702368
15ZAP701.91351732
16JAK31.83923472
17BLK1.73902355
18IRAK41.72663396
19TNK21.70783496
20SYK1.68263659
21IKBKE1.60784115
22MAP3K101.60718856
23MAP4K21.54664302
24MARK31.49222755
25LCK1.49172529
26HCK1.47825857
27SIK31.45725071
28TEC1.45649769
29SIK21.42318219
30CSK1.40211921
31EPHB11.30291407
32JAK11.28347935
33JAK21.26302662
34SCYL21.24889339
35CAMK41.14589837
36MAPK131.14155746
37UHMK11.14022920
38LYN1.12662910
39NLK1.12607065
40MAP2K31.11960939
41NTRK21.10754522
42STK381.09499183
43CLK11.08655687
44MARK21.07085033
45YES11.00216803
46EPHA30.99940428
47FGR0.99511544
48CSF1R0.95747565
49TBK10.94808241
50MAP3K140.91702008
51DYRK1B0.91480660
52HIPK20.88847947
53PDK10.88422906
54MARK10.83334738
55PIM10.81658602
56BCKDK0.80425878
57TYRO30.75067110
58KSR20.70104905
59MAP3K130.68290187
60MAP3K110.66877933
61TESK20.65218383
62MAP3K10.64312236
63DYRK1A0.63727494
64IKBKB0.62899791
65MAP3K70.60217724
66PTK2B0.58382881
67PRKCQ0.57916236
68MAPK120.57153839
69OXSR10.54139593
70FYN0.52489930
71BMPR20.52215655
72EPHA40.51369084
73MAPK110.51264006
74MAPK70.50044376
75STK110.46454744
76RPS6KA40.43026903
77MAP3K90.37858692
78EGFR0.37683676
79SGK20.37352817
80STK100.36930998
81DYRK30.34247612
82TAOK10.34246189
83CDK50.33807036
84WNK30.33674208
85MAP3K30.33366285
86ERN10.31606533
87RAF10.30337472
88PRKCZ0.29951899
89MAPK80.28308502
90RET0.27757328
91PDPK10.26803413
92MAP2K70.26656979
93CAMK10.26602693
94NEK60.26476922
95BCR0.25143873
96SGK30.24135381
97CDK40.23449057
98MAPK40.23100188
99GRK50.22755458
100TGFBR20.22272822

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.76961135
2T cell receptor signaling pathway_Homo sapiens_hsa046603.03570465
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.51884235
4Osteoclast differentiation_Homo sapiens_hsa043802.39087750
5Acute myeloid leukemia_Homo sapiens_hsa052212.02198620
6B cell receptor signaling pathway_Homo sapiens_hsa046622.00818900
7Measles_Homo sapiens_hsa051621.98439340
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.86242138
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84216987
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81856896
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68346075
12Allograft rejection_Homo sapiens_hsa053301.67091820
13Autoimmune thyroid disease_Homo sapiens_hsa053201.65373574
14Hematopoietic cell lineage_Homo sapiens_hsa046401.64778164
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.59956138
16Non-small cell lung cancer_Homo sapiens_hsa052231.55488999
17Chemokine signaling pathway_Homo sapiens_hsa040621.52529528
18Leishmaniasis_Homo sapiens_hsa051401.52492357
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51139464
20Graft-versus-host disease_Homo sapiens_hsa053321.41833646
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.40795151
22Tuberculosis_Homo sapiens_hsa051521.35216795
23Hepatitis B_Homo sapiens_hsa051611.35050990
24Herpes simplex infection_Homo sapiens_hsa051681.31482758
25Colorectal cancer_Homo sapiens_hsa052101.30023954
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24978441
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22849508
28Endometrial cancer_Homo sapiens_hsa052131.19029309
29VEGF signaling pathway_Homo sapiens_hsa043701.17838607
30TNF signaling pathway_Homo sapiens_hsa046681.14013111
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12924047
32Platelet activation_Homo sapiens_hsa046111.11226250
33Inositol phosphate metabolism_Homo sapiens_hsa005621.10409398
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09694227
35Regulation of autophagy_Homo sapiens_hsa041401.09152644
36Collecting duct acid secretion_Homo sapiens_hsa049661.07677946
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.07322452
38Influenza A_Homo sapiens_hsa051641.06959426
39Pancreatic cancer_Homo sapiens_hsa052121.04811554
40FoxO signaling pathway_Homo sapiens_hsa040681.03935425
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01474148
42Shigellosis_Homo sapiens_hsa051311.00803347
43Legionellosis_Homo sapiens_hsa051341.00306674
44Renal cell carcinoma_Homo sapiens_hsa052110.99587476
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.99351487
46Epstein-Barr virus infection_Homo sapiens_hsa051690.98814805
47Apoptosis_Homo sapiens_hsa042100.98211989
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98116655
49Synaptic vesicle cycle_Homo sapiens_hsa047210.97131490
50Viral myocarditis_Homo sapiens_hsa054160.95696979
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93969753
52Type I diabetes mellitus_Homo sapiens_hsa049400.92815620
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92458751
54Toxoplasmosis_Homo sapiens_hsa051450.91640021
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91488872
56Viral carcinogenesis_Homo sapiens_hsa052030.90267409
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.89627380
58Endocytosis_Homo sapiens_hsa041440.87095569
59Morphine addiction_Homo sapiens_hsa050320.86439459
60Antigen processing and presentation_Homo sapiens_hsa046120.86045665
61Phagosome_Homo sapiens_hsa041450.85963763
62Prolactin signaling pathway_Homo sapiens_hsa049170.84402311
63Nicotine addiction_Homo sapiens_hsa050330.83868988
64Long-term potentiation_Homo sapiens_hsa047200.83287823
65Choline metabolism in cancer_Homo sapiens_hsa052310.81984421
66Chronic myeloid leukemia_Homo sapiens_hsa052200.79604695
67mTOR signaling pathway_Homo sapiens_hsa041500.79469797
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78632220
69Other glycan degradation_Homo sapiens_hsa005110.78431891
70Staphylococcus aureus infection_Homo sapiens_hsa051500.77422634
71Dorso-ventral axis formation_Homo sapiens_hsa043200.75855258
72ErbB signaling pathway_Homo sapiens_hsa040120.73381456
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.73246817
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73234554
75Cholinergic synapse_Homo sapiens_hsa047250.71821225
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.66664604
77Hepatitis C_Homo sapiens_hsa051600.65578233
78MAPK signaling pathway_Homo sapiens_hsa040100.63637748
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.62265590
80HTLV-I infection_Homo sapiens_hsa051660.60337070
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59644030
82Ras signaling pathway_Homo sapiens_hsa040140.58725985
83Basal transcription factors_Homo sapiens_hsa030220.58403489
84mRNA surveillance pathway_Homo sapiens_hsa030150.56653557
85Malaria_Homo sapiens_hsa051440.55374530
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54706395
87Rheumatoid arthritis_Homo sapiens_hsa053230.52929571
88GABAergic synapse_Homo sapiens_hsa047270.52002218
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51007903
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50736242
91Amphetamine addiction_Homo sapiens_hsa050310.50170920
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.49279449
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48133134
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47765734
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47086392
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45468145
97Thyroid cancer_Homo sapiens_hsa052160.44950075
98Type II diabetes mellitus_Homo sapiens_hsa049300.44546356
99Salmonella infection_Homo sapiens_hsa051320.44039001
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43701072

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