ZNF808

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)4.88093634
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.18791057
3regulation of translation, ncRNA-mediated (GO:0045974)4.18791057
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.18791057
5establishment of protein localization to Golgi (GO:0072600)3.85685774
6interferon-gamma production (GO:0032609)3.84752317
7activated T cell proliferation (GO:0050798)3.78653145
8rRNA catabolic process (GO:0016075)3.74875144
9positive regulation of granulocyte differentiation (GO:0030854)3.69868411
10histone H3-K4 trimethylation (GO:0080182)3.65103956
11protein prenylation (GO:0018342)3.55271222
12prenylation (GO:0097354)3.55271222
13cellular response to ethanol (GO:0071361)3.54326355
14interkinetic nuclear migration (GO:0022027)3.39264682
15peptidyl-lysine trimethylation (GO:0018023)3.35549607
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.35039162
17regulation of B cell receptor signaling pathway (GO:0050855)3.29585296
18protein targeting to Golgi (GO:0000042)3.29101676
19protein K63-linked deubiquitination (GO:0070536)3.28776531
20positive regulation of gamma-delta T cell activation (GO:0046645)3.26593089
21monoubiquitinated protein deubiquitination (GO:0035520)3.21382000
22regulation of gamma-delta T cell differentiation (GO:0045586)3.21025639
23histone H3-K9 methylation (GO:0051567)3.19436661
24neural tube formation (GO:0001841)3.16560511
25retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12239537
26positive regulation of developmental pigmentation (GO:0048087)3.11925876
27DNA deamination (GO:0045006)3.07968455
28positive regulation of mRNA catabolic process (GO:0061014)3.06055054
29DNA double-strand break processing (GO:0000729)3.05270978
30DNA demethylation (GO:0080111)2.99933905
31protein K48-linked deubiquitination (GO:0071108)2.95202884
32positive regulation of defense response to virus by host (GO:0002230)2.92972080
33protein localization to Golgi apparatus (GO:0034067)2.92486269
34regulation of gamma-delta T cell activation (GO:0046643)2.92058345
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88137876
36negative regulation of cell killing (GO:0031342)2.88137876
37negative regulation of DNA-dependent DNA replication (GO:2000104)2.84355279
38cytoplasmic mRNA processing body assembly (GO:0033962)2.82708293
39peptidyl-lysine methylation (GO:0018022)2.82010475
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81966293
41mast cell degranulation (GO:0043303)2.79966281
42mast cell activation involved in immune response (GO:0002279)2.79966281
43histone mRNA catabolic process (GO:0071044)2.76706520
44negative T cell selection (GO:0043383)2.76134837
45cellular response to interleukin-15 (GO:0071350)2.75595769
46histone H3-K9 modification (GO:0061647)2.75526959
47L-fucose catabolic process (GO:0042355)2.74469622
48fucose catabolic process (GO:0019317)2.74469622
49L-fucose metabolic process (GO:0042354)2.74469622
50negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73991771
51regulation of memory T cell differentiation (GO:0043380)2.70482655
52regulation of regulatory T cell differentiation (GO:0045589)2.67084828
53Golgi to endosome transport (GO:0006895)2.66916838
54replication fork processing (GO:0031297)2.66168170
55regulation of mRNA catabolic process (GO:0061013)2.61569928
56histone-serine phosphorylation (GO:0035404)2.61017005
57DNA dealkylation (GO:0035510)2.59932142
58double-strand break repair via homologous recombination (GO:0000724)2.58900358
59positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.58232488
60regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.58232488
61positive T cell selection (GO:0043368)2.57615403
62recombinational repair (GO:0000725)2.57527124
63tryptophan metabolic process (GO:0006568)2.57030831
64tryptophan catabolic process (GO:0006569)2.55804185
65indole-containing compound catabolic process (GO:0042436)2.55804185
66indolalkylamine catabolic process (GO:0046218)2.55804185
67regulation of establishment of cell polarity (GO:2000114)2.55618292
68regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53672280
69positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53672280
70histone lysine methylation (GO:0034968)2.51642207
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50768265
72negative thymic T cell selection (GO:0045060)2.50493600
73indolalkylamine metabolic process (GO:0006586)2.49552350
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.48915377
75B cell receptor signaling pathway (GO:0050853)2.47625941
76microtubule anchoring (GO:0034453)2.47001884
77response to interleukin-15 (GO:0070672)2.46383445
78mast cell activation (GO:0045576)2.45120385
79embryonic hemopoiesis (GO:0035162)2.44952081
80positive regulation of histone H3-K4 methylation (GO:0051571)2.44729260
81replicative senescence (GO:0090399)2.42664294
82histone H3-K36 demethylation (GO:0070544)2.41294450
83photoreceptor cell maintenance (GO:0045494)2.41061436
84peptidyl-threonine dephosphorylation (GO:0035970)2.38784252
85reciprocal DNA recombination (GO:0035825)2.37296901
86reciprocal meiotic recombination (GO:0007131)2.37296901
87positive regulation of mRNA metabolic process (GO:1903313)2.37160221
88negative regulation of T cell mediated immunity (GO:0002710)2.36956458
89regulation of pigment cell differentiation (GO:0050932)2.35608522
90regulation of germinal center formation (GO:0002634)2.33625690
91regulation of DNA endoreduplication (GO:0032875)2.32644202
92ncRNA catabolic process (GO:0034661)2.29465073
93regulation of telomere maintenance (GO:0032204)2.28254663
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.28038345
95negative regulation of thymocyte apoptotic process (GO:0070244)2.26149160
96cellular response to exogenous dsRNA (GO:0071360)2.26135491
97mitotic sister chromatid cohesion (GO:0007064)2.24957351
98intra-Golgi vesicle-mediated transport (GO:0006891)2.24563370
99positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.24250173
100sister chromatid cohesion (GO:0007062)2.21947373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80909063
2ZNF274_21170338_ChIP-Seq_K562_Hela2.94928768
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.84142373
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.83602553
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66053567
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.58745910
7IGF1R_20145208_ChIP-Seq_DFB_Human2.41428267
8GBX2_23144817_ChIP-Seq_PC3_Human2.41171512
9TAF15_26573619_Chip-Seq_HEK293_Human2.33602673
10GATA1_22025678_ChIP-Seq_K562_Human2.32220216
11VDR_22108803_ChIP-Seq_LS180_Human2.31583714
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30766072
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19806340
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18159355
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15799701
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11134767
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.09343144
18FUS_26573619_Chip-Seq_HEK293_Human2.03079691
19EWS_26573619_Chip-Seq_HEK293_Human1.96501290
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94016523
21ER_23166858_ChIP-Seq_MCF-7_Human1.93436626
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85695444
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82179216
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81835208
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.76372637
26P300_19829295_ChIP-Seq_ESCs_Human1.74174727
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68584715
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66772458
29CBP_20019798_ChIP-Seq_JUKART_Human1.66772458
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.66186105
31IRF1_19129219_ChIP-ChIP_H3396_Human1.64664858
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60412009
33STAT3_23295773_ChIP-Seq_U87_Human1.57222405
34RUNX_20019798_ChIP-Seq_JUKART_Human1.55773814
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51679813
36SMAD4_21799915_ChIP-Seq_A2780_Human1.50903267
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49537198
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48791296
39TCF4_23295773_ChIP-Seq_U87_Human1.48333587
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47686088
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44562378
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.43359436
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43179228
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38910373
45ELK1_19687146_ChIP-ChIP_HELA_Human1.38323946
46BCAT_22108803_ChIP-Seq_LS180_Human1.36194297
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34685434
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32617096
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.32350760
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31604793
51GATA3_26560356_Chip-Seq_TH2_Human1.28766578
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27652990
53CDX2_22108803_ChIP-Seq_LS180_Human1.23702049
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23572028
55MYB_26560356_Chip-Seq_TH2_Human1.23489923
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23029662
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23019607
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.22811062
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.22620541
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.21786711
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20448567
62VDR_23849224_ChIP-Seq_CD4+_Human1.20079195
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19541223
64TP53_16413492_ChIP-PET_HCT116_Human1.19404786
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19285202
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18987767
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18987767
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17434717
69AR_25329375_ChIP-Seq_VCAP_Human1.16151725
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16001940
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.14604825
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14401538
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.14370322
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.13650428
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12843492
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12634438
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10823797
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.09166058
79AR_21572438_ChIP-Seq_LNCaP_Human1.08900319
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08741365
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07716217
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.07425130
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07381736
84* TCF4_22108803_ChIP-Seq_LS180_Human1.07376473
85SALL4_22934838_ChIP-ChIP_CD34+_Human1.06756651
86GATA3_27048872_Chip-Seq_THYMUS_Human1.06592886
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06242763
88P53_22387025_ChIP-Seq_ESCs_Mouse1.06205428
89TP53_22573176_ChIP-Seq_HFKS_Human1.03647903
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03632866
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02905003
92RUNX2_22187159_ChIP-Seq_PCA_Human1.02312967
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02159095
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01399100
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00068209
96P300_18555785_Chip-Seq_ESCs_Mouse0.99636685
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99610379
98AHR_22903824_ChIP-Seq_MCF-7_Human0.98152433
99EST1_17652178_ChIP-ChIP_JURKAT_Human0.98114479
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.97781060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.40812016
2MP0008057_abnormal_DNA_replication4.25059668
3MP0008877_abnormal_DNA_methylation2.89050574
4MP0003646_muscle_fatigue2.72356298
5MP0001835_abnormal_antigen_presentation2.54965829
6MP0003763_abnormal_thymus_physiology2.41339457
7MP0003787_abnormal_imprinting2.28743118
8MP0005671_abnormal_response_to2.07944059
9MP0005174_abnormal_tail_pigmentation2.05788529
10MP0004484_altered_response_of2.01142379
11MP0000427_abnormal_hair_cycle1.98569912
12MP0005075_abnormal_melanosome_morpholog1.94281577
13MP0002009_preneoplasia1.94239344
14MP0002837_dystrophic_cardiac_calcinosis1.91809686
15MP0000015_abnormal_ear_pigmentation1.90006882
16MP0002138_abnormal_hepatobiliary_system1.84548735
17MP0005645_abnormal_hypothalamus_physiol1.83250693
18MP0002638_abnormal_pupillary_reflex1.80727348
19MP0003724_increased_susceptibility_to1.75444360
20MP0001800_abnormal_humoral_immune1.74876981
21MP0004043_abnormal_pH_regulation1.60948907
22MP0004215_abnormal_myocardial_fiber1.50183503
23MP0010094_abnormal_chromosome_stability1.45195709
24MP0002166_altered_tumor_susceptibility1.44220729
25MP0004145_abnormal_muscle_electrophysio1.41969339
26MP0004142_abnormal_muscle_tone1.39988615
27MP0000383_abnormal_hair_follicle1.34568029
28MP0004084_abnormal_cardiac_muscle1.34146302
29MP0009764_decreased_sensitivity_to1.32580840
30MP0008058_abnormal_DNA_repair1.32466397
31MP0005310_abnormal_salivary_gland1.32400312
32MP0001984_abnormal_olfaction1.30532626
33MP0002452_abnormal_antigen_presenting1.30316713
34MP0000689_abnormal_spleen_morphology1.30022734
35MP0004130_abnormal_muscle_cell1.29574376
36MP0000372_irregular_coat_pigmentation1.29546578
37MP0006072_abnormal_retinal_apoptosis1.28867753
38MP0002723_abnormal_immune_serum1.28733392
39MP0005253_abnormal_eye_physiology1.28399685
40MP0002095_abnormal_skin_pigmentation1.27330696
41MP0002420_abnormal_adaptive_immunity1.24928174
42MP0004147_increased_porphyrin_level1.24456608
43MP0004381_abnormal_hair_follicle1.24231653
44MP0002102_abnormal_ear_morphology1.24071151
45MP0001819_abnormal_immune_cell1.23835154
46MP0003195_calcinosis1.22427686
47MP0002398_abnormal_bone_marrow1.19216207
48MP0005266_abnormal_metabolism1.17925862
49MP0001919_abnormal_reproductive_system1.16885395
50MP0005389_reproductive_system_phenotype1.15317052
51MP0000685_abnormal_immune_system1.15105134
52MP0002928_abnormal_bile_duct1.11972125
53MP0002396_abnormal_hematopoietic_system1.11855681
54MP0003045_fibrosis1.11769522
55MP0000465_gastrointestinal_hemorrhage1.09725627
56MP0005551_abnormal_eye_electrophysiolog1.09081318
57MP0005646_abnormal_pituitary_gland1.08163161
58MP0000716_abnormal_immune_system1.07756096
59MP0002332_abnormal_exercise_endurance1.06805674
60MP0002405_respiratory_system_inflammati1.06583427
61MP0000703_abnormal_thymus_morphology1.05043060
62MP0003656_abnormal_erythrocyte_physiolo1.04122389
63MP0002722_abnormal_immune_system1.03506207
64MP0002006_tumorigenesis1.02438934
65MP0001790_abnormal_immune_system1.01564958
66MP0005387_immune_system_phenotype1.01564958
67MP0004808_abnormal_hematopoietic_stem1.00044302
68MP0001501_abnormal_sleep_pattern0.99595965
69MP0003252_abnormal_bile_duct0.97917498
70MP0005167_abnormal_blood-brain_barrier0.97830022
71MP0001986_abnormal_taste_sensitivity0.96282364
72MP0003890_abnormal_embryonic-extraembry0.95786335
73MP0005000_abnormal_immune_tolerance0.94777871
74MP0008995_early_reproductive_senescence0.93485447
75MP0002127_abnormal_cardiovascular_syste0.93387564
76MP0003121_genomic_imprinting0.92621244
77MP0008961_abnormal_basal_metabolism0.87823227
78MP0004036_abnormal_muscle_relaxation0.86390175
79MP0002419_abnormal_innate_immunity0.84062954
80MP0000371_diluted_coat_color0.84033506
81MP0003828_pulmonary_edema0.81873352
82MP0006054_spinal_hemorrhage0.81345907
83MP0009785_altered_susceptibility_to0.80532008
84MP0003786_premature_aging0.80272263
85MP0002160_abnormal_reproductive_system0.78875868
86MP0010678_abnormal_skin_adnexa0.76841237
87MP0002429_abnormal_blood_cell0.75976005
88MP0002693_abnormal_pancreas_physiology0.75193582
89MP0003866_abnormal_defecation0.74547882
90MP0003136_yellow_coat_color0.73364228
91MP0003183_abnormal_peptide_metabolism0.72833253
92MP0004264_abnormal_extraembryonic_tissu0.71314648
93MP0001929_abnormal_gametogenesis0.71159557
94MP0000647_abnormal_sebaceous_gland0.71151340
95MP0004924_abnormal_behavior0.70200906
96MP0005386_behavior/neurological_phenoty0.70200906
97MP0005397_hematopoietic_system_phenotyp0.68776472
98MP0001545_abnormal_hematopoietic_system0.68776472
99MP0001873_stomach_inflammation0.66855723
100MP0005025_abnormal_response_to0.65797829

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.69592463
2Abnormality of the renal cortex (HP:0011035)3.29965004
3Nephronophthisis (HP:0000090)3.18198698
4Abnormality of chromosome stability (HP:0003220)3.15960254
5Pancreatic fibrosis (HP:0100732)3.13193659
6T lymphocytopenia (HP:0005403)3.07665296
7Abnormality of the renal medulla (HP:0100957)2.94610680
8Abnormality of T cell number (HP:0011839)2.93933047
9Thyroiditis (HP:0100646)2.90604352
10Renal cortical cysts (HP:0000803)2.88793742
11Molar tooth sign on MRI (HP:0002419)2.88137586
12Abnormality of midbrain morphology (HP:0002418)2.88137586
13True hermaphroditism (HP:0010459)2.87750487
14Gaze-evoked nystagmus (HP:0000640)2.83966357
15Medial flaring of the eyebrow (HP:0010747)2.82784655
16Abnormal delayed hypersensitivity skin test (HP:0002963)2.82292635
17Clubbing of toes (HP:0100760)2.81125870
18Hyperventilation (HP:0002883)2.70710306
19Fair hair (HP:0002286)2.70054490
20Chronic mucocutaneous candidiasis (HP:0002728)2.69247268
21Recurrent cutaneous fungal infections (HP:0011370)2.69247268
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.66114405
23Elevated erythrocyte sedimentation rate (HP:0003565)2.65425186
24Stomatitis (HP:0010280)2.62983929
25Stomach cancer (HP:0012126)2.61860959
26Chronic hepatic failure (HP:0100626)2.52467361
27Panhypogammaglobulinemia (HP:0003139)2.49652032
28Severe combined immunodeficiency (HP:0004430)2.40573428
29Widely spaced teeth (HP:0000687)2.38021256
30IgG deficiency (HP:0004315)2.37002870
31Decreased circulating renin level (HP:0003351)2.35020594
32Abnormality of T cells (HP:0002843)2.32388038
33Genetic anticipation (HP:0003743)2.31536812
34Protruding tongue (HP:0010808)2.25325016
35Generalized hypopigmentation of hair (HP:0011358)2.21788495
36Poor coordination (HP:0002370)2.21377316
37Congenital stationary night blindness (HP:0007642)2.20295388
38Recurrent fungal infections (HP:0002841)2.18151317
39Congenital primary aphakia (HP:0007707)2.16055129
40Volvulus (HP:0002580)2.13540502
41Tubulointerstitial nephritis (HP:0001970)2.11876309
42IgM deficiency (HP:0002850)2.11794497
43Methylmalonic acidemia (HP:0002912)2.11764056
44Chromsome breakage (HP:0040012)2.10822449
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09509839
46Retrobulbar optic neuritis (HP:0100654)2.08806939
47Optic neuritis (HP:0100653)2.08806939
48Attenuation of retinal blood vessels (HP:0007843)2.08380963
49Abnormality of DNA repair (HP:0003254)2.07820436
50Abnormality of the ileum (HP:0001549)2.07593388
51Abnormal drinking behavior (HP:0030082)2.06691428
52Polydipsia (HP:0001959)2.06691428
53Gait imbalance (HP:0002141)2.05877100
54Meckel diverticulum (HP:0002245)2.04622482
55Progressive cerebellar ataxia (HP:0002073)2.03562054
56Abnormal rod and cone electroretinograms (HP:0008323)2.02938866
57Abnormal hair whorl (HP:0010721)2.02366793
58Nephrogenic diabetes insipidus (HP:0009806)2.00976435
59Abnormality of eosinophils (HP:0001879)2.00513170
60Prominent nose (HP:0000448)1.99783621
61Aplasia/Hypoplasia of the tibia (HP:0005772)1.99757992
62Duplicated collecting system (HP:0000081)1.95136379
63Febrile seizures (HP:0002373)1.94601351
64Acute myeloid leukemia (HP:0004808)1.92530230
65Hip dysplasia (HP:0001385)1.91326599
66Broad-based gait (HP:0002136)1.91218485
67Sloping forehead (HP:0000340)1.91216363
68Small hand (HP:0200055)1.89784962
69Hematochezia (HP:0002573)1.88061190
70Abnormality of the preputium (HP:0100587)1.86027195
71Cystic liver disease (HP:0006706)1.85822469
72Abnormality of the renal collecting system (HP:0004742)1.85086580
73Bile duct proliferation (HP:0001408)1.84463000
74Abnormal biliary tract physiology (HP:0012439)1.84463000
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.83671302
76Albinism (HP:0001022)1.83476877
77Astigmatism (HP:0000483)1.82530803
78Progressive inability to walk (HP:0002505)1.82136057
79Abnormality of vitamin B metabolism (HP:0004340)1.81856865
80Abnormality of T cell physiology (HP:0011840)1.81405062
81Type II lissencephaly (HP:0007260)1.80300145
82Abnormality of the vitamin B12 metabolism (HP:0004341)1.75327967
83Combined immunodeficiency (HP:0005387)1.75261635
84Prostate neoplasm (HP:0100787)1.75244639
85Clumsiness (HP:0002312)1.74736611
86Tubular atrophy (HP:0000092)1.73965098
87Congenital hepatic fibrosis (HP:0002612)1.72262318
88Calf muscle hypertrophy (HP:0008981)1.72188710
89Truncal obesity (HP:0001956)1.72057818
90Myelodysplasia (HP:0002863)1.71062750
91Degeneration of the lateral corticospinal tracts (HP:0002314)1.69631823
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69631823
93Leukocytosis (HP:0001974)1.69599394
94Inability to walk (HP:0002540)1.68979345
95Keratoconjunctivitis (HP:0001096)1.68054397
96Abolished electroretinogram (ERG) (HP:0000550)1.68030100
97Papillary thyroid carcinoma (HP:0002895)1.67562114
98Abnormality of B cell number (HP:0010975)1.67536749
99Large for gestational age (HP:0001520)1.67382672
100Absent speech (HP:0001344)1.66861896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.19729712
2TAOK32.75450074
3ZAK2.57903387
4WNK32.37966879
5BMPR1B2.32710581
6OBSCN2.31129287
7TXK2.27188007
8NLK2.20571300
9ACVR1B2.19490324
10NUAK12.13082062
11TEC2.00831877
12EIF2AK32.00318395
13MAP4K21.96627108
14BRD41.87540535
15BRSK21.86315886
16CAMKK21.75714055
17BLK1.68502109
18TNIK1.66576152
19MARK31.62358031
20TLK11.50947594
21MAP3K41.50827184
22VRK11.35957726
23GRK11.32062580
24BTK1.30097943
25MAPK131.29727791
26ADRBK21.29010469
27MAP4K11.25182020
28SGK21.18045227
29CAMK1D1.17966822
30PIK3CG1.17484695
31ERBB31.12306059
32JAK11.12214321
33PIK3CA1.11836319
34PINK11.07399228
35AKT31.06774445
36BMPR21.06536251
37SYK1.05946962
38INSRR1.04969422
39OXSR11.03459053
40KIT1.02924429
41GRK70.98289897
42IRAK10.98200973
43ITK0.97446827
44TRPM70.94782508
45FES0.93892809
46EPHA30.90834435
47LATS10.90530054
48IKBKE0.83481206
49CAMK1G0.81083319
50TYK20.79527938
51PIM10.78007697
52PRKCQ0.75070073
53PLK40.73672759
54MKNK20.73046574
55HCK0.72830015
56CASK0.66842039
57LCK0.66749853
58PRKCE0.65688646
59CAMK40.65352427
60IKBKB0.63609939
61LYN0.63435022
62WNK10.62505469
63EIF2AK20.60595035
64JAK20.60167617
65FLT30.59377105
66STK38L0.57508294
67STK110.57466168
68ATM0.53972657
69MELK0.53031374
70TNK20.52497859
71PKN20.52065120
72MAPK70.51590104
73PAK30.50550200
74PNCK0.50538311
75PLK30.50518284
76MST40.50456242
77SGK4940.49452053
78SGK2230.49452053
79RPS6KA50.48285534
80FGFR30.48057147
81ATR0.47922082
82TIE10.47799049
83TGFBR10.47550080
84JAK30.47223659
85MAP3K140.45708959
86YES10.45613642
87CSK0.44618707
88MAP3K70.44594011
89CHUK0.44083733
90TGFBR20.43696980
91CCNB10.43613720
92EGFR0.43124731
93PLK20.42569840
94PRKAA20.41783209
95SGK30.41697236
96ZAP700.41004564
97STK30.37922042
98SGK10.37235051
99MAP2K70.37118795
100PTK2B0.35801753

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.77809579
2Primary immunodeficiency_Homo sapiens_hsa053402.35992644
3Homologous recombination_Homo sapiens_hsa034402.19917163
4Circadian rhythm_Homo sapiens_hsa047102.03771787
5Selenocompound metabolism_Homo sapiens_hsa004502.03309815
6Basal transcription factors_Homo sapiens_hsa030221.88493787
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88118423
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83136160
9Graft-versus-host disease_Homo sapiens_hsa053321.78215249
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.78152840
11Dorso-ventral axis formation_Homo sapiens_hsa043201.76128222
12RNA degradation_Homo sapiens_hsa030181.74762593
13Linoleic acid metabolism_Homo sapiens_hsa005911.72325013
14Phototransduction_Homo sapiens_hsa047441.61978725
15Regulation of autophagy_Homo sapiens_hsa041401.61054816
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.58095002
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56221763
18Non-homologous end-joining_Homo sapiens_hsa034501.49612773
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45186277
20Propanoate metabolism_Homo sapiens_hsa006401.44867378
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43017649
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42881716
23T cell receptor signaling pathway_Homo sapiens_hsa046601.40860781
24Ether lipid metabolism_Homo sapiens_hsa005651.39401348
25Asthma_Homo sapiens_hsa053101.38935471
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38920477
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35663528
28Allograft rejection_Homo sapiens_hsa053301.35138294
29Type I diabetes mellitus_Homo sapiens_hsa049401.27258601
30Systemic lupus erythematosus_Homo sapiens_hsa053221.25978306
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24691773
32Autoimmune thyroid disease_Homo sapiens_hsa053201.21797253
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19914903
34Measles_Homo sapiens_hsa051621.16318295
35Olfactory transduction_Homo sapiens_hsa047401.12831191
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10308507
37Lysine degradation_Homo sapiens_hsa003101.10284666
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.09489752
39Butanoate metabolism_Homo sapiens_hsa006501.08882183
40Taste transduction_Homo sapiens_hsa047421.07703905
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07140939
42B cell receptor signaling pathway_Homo sapiens_hsa046621.05532922
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01437404
44FoxO signaling pathway_Homo sapiens_hsa040680.98868690
45Nitrogen metabolism_Homo sapiens_hsa009100.97063891
46Nucleotide excision repair_Homo sapiens_hsa034200.90753626
47Hematopoietic cell lineage_Homo sapiens_hsa046400.90714494
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90388455
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90302832
50Platelet activation_Homo sapiens_hsa046110.85517627
51Leishmaniasis_Homo sapiens_hsa051400.84694665
52RNA polymerase_Homo sapiens_hsa030200.84163472
53ABC transporters_Homo sapiens_hsa020100.83906581
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82688929
55Mismatch repair_Homo sapiens_hsa034300.82523504
56One carbon pool by folate_Homo sapiens_hsa006700.81186200
57Herpes simplex infection_Homo sapiens_hsa051680.81097231
58Antigen processing and presentation_Homo sapiens_hsa046120.78862466
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78516173
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74811480
61Osteoclast differentiation_Homo sapiens_hsa043800.74730561
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73398818
63Alcoholism_Homo sapiens_hsa050340.72202007
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71589977
65Hepatitis B_Homo sapiens_hsa051610.70297682
66Tryptophan metabolism_Homo sapiens_hsa003800.69501747
67Influenza A_Homo sapiens_hsa051640.66764944
68Legionellosis_Homo sapiens_hsa051340.65695316
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65616753
70Ovarian steroidogenesis_Homo sapiens_hsa049130.65567331
71Inositol phosphate metabolism_Homo sapiens_hsa005620.63081386
72Calcium signaling pathway_Homo sapiens_hsa040200.62994367
73Oxytocin signaling pathway_Homo sapiens_hsa049210.62627697
74Viral carcinogenesis_Homo sapiens_hsa052030.62154411
75Insulin resistance_Homo sapiens_hsa049310.60806223
76Tuberculosis_Homo sapiens_hsa051520.58992565
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.58136831
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56614992
79TNF signaling pathway_Homo sapiens_hsa046680.55639881
80p53 signaling pathway_Homo sapiens_hsa041150.55181733
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.54519964
82Peroxisome_Homo sapiens_hsa041460.52641493
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51396025
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50344218
85Choline metabolism in cancer_Homo sapiens_hsa052310.48480501
86Staphylococcus aureus infection_Homo sapiens_hsa051500.47413740
87Caffeine metabolism_Homo sapiens_hsa002320.44812350
88Prolactin signaling pathway_Homo sapiens_hsa049170.43771430
89cAMP signaling pathway_Homo sapiens_hsa040240.43458797
90Prostate cancer_Homo sapiens_hsa052150.43055634
91Salivary secretion_Homo sapiens_hsa049700.42923434
92Mineral absorption_Homo sapiens_hsa049780.42330840
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41884359
94Renin secretion_Homo sapiens_hsa049240.39807973
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39466303
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39178094
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.38970725
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38885001
99Serotonergic synapse_Homo sapiens_hsa047260.37457655
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36314709

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