ZNF805

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.65157362
2nuclear pore organization (GO:0006999)5.63540346
3pore complex assembly (GO:0046931)4.82002440
4mitotic sister chromatid cohesion (GO:0007064)4.80489847
5embryonic process involved in female pregnancy (GO:0060136)4.70916643
6monoubiquitinated protein deubiquitination (GO:0035520)4.18252966
7regulation of RNA export from nucleus (GO:0046831)4.13048591
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.97477953
9cytoplasmic mRNA processing body assembly (GO:0033962)3.93617663
10definitive hemopoiesis (GO:0060216)3.90564104
11interkinetic nuclear migration (GO:0022027)3.79173339
12dosage compensation (GO:0007549)3.60137236
13regulation of histone H3-K9 methylation (GO:0051570)3.52637883
14histone H3-K36 demethylation (GO:0070544)3.51575218
15regulation of NFAT protein import into nucleus (GO:0051532)3.50886535
16negative regulation of DNA repair (GO:0045738)3.49031868
17COPII vesicle coating (GO:0048208)3.43844960
18regulation of nucleobase-containing compound transport (GO:0032239)3.33109530
19positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.31737338
20histone mRNA catabolic process (GO:0071044)3.28824290
21protein K48-linked deubiquitination (GO:0071108)3.18279740
22negative regulation of histone methylation (GO:0031061)3.18082170
23pre-miRNA processing (GO:0031054)3.17665045
24cellular response to ethanol (GO:0071361)3.16882963
25positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13615508
26positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13615508
27positive regulation of mitotic sister chromatid separation (GO:1901970)3.13615508
28mitotic chromosome condensation (GO:0007076)3.13082177
29protein K11-linked deubiquitination (GO:0035871)3.05595378
30regulation of transforming growth factor beta2 production (GO:0032909)3.04277342
31protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.92777813
32pyrimidine dimer repair (GO:0006290)2.87471407
33histone lysine demethylation (GO:0070076)2.87304091
34negative regulation of translation, ncRNA-mediated (GO:0040033)2.86225976
35regulation of translation, ncRNA-mediated (GO:0045974)2.86225976
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86225976
37histone H3-K4 trimethylation (GO:0080182)2.86169075
38histone H3-K9 demethylation (GO:0033169)2.83348053
39positive regulation of DNA-templated transcription, initiation (GO:2000144)2.82435254
40N-terminal protein amino acid acetylation (GO:0006474)2.81136269
41histone demethylation (GO:0016577)2.73810608
42chondrocyte development (GO:0002063)2.72995328
43fibroblast migration (GO:0010761)2.66951457
44histone H3-K4 methylation (GO:0051568)2.66070332
45protein destabilization (GO:0031648)2.65082467
46regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.63531758
47nucleus organization (GO:0006997)2.63366522
48peptidyl-lysine trimethylation (GO:0018023)2.60456163
49negative regulation of fibroblast apoptotic process (GO:2000270)2.59262404
50nucleus localization (GO:0051647)2.54828668
51regulation of centriole replication (GO:0046599)2.54234663
52positive regulation of mRNA 3-end processing (GO:0031442)2.53424701
53mitotic nuclear envelope disassembly (GO:0007077)2.53038854
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52922328
55nuclear envelope disassembly (GO:0051081)2.52542735
56membrane disassembly (GO:0030397)2.52542735
57labyrinthine layer development (GO:0060711)2.50090980
58protein demethylation (GO:0006482)2.44943191
59protein dealkylation (GO:0008214)2.44943191
60positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.44653196
61response to UV-C (GO:0010225)2.43953886
62germ cell migration (GO:0008354)2.43479068
63protein K63-linked deubiquitination (GO:0070536)2.41399122
64negative regulation of histone modification (GO:0031057)2.40808051
65morphogenesis of an epithelial sheet (GO:0002011)2.39933000
66regulation of steroid hormone biosynthetic process (GO:0090030)2.39783301
67embryonic camera-type eye morphogenesis (GO:0048596)2.39633798
68histone phosphorylation (GO:0016572)2.38170386
69SMAD protein complex assembly (GO:0007183)2.38046482
70snRNA transcription (GO:0009301)2.37790795
71oocyte development (GO:0048599)2.36879817
72regulation of fibroblast apoptotic process (GO:2000269)2.34265309
73nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.32547017
74histone-serine phosphorylation (GO:0035404)2.31596805
75regulation of mRNA 3-end processing (GO:0031440)2.30706367
76NLS-bearing protein import into nucleus (GO:0006607)2.30695875
77sister chromatid cohesion (GO:0007062)2.29750565
78establishment of protein localization to Golgi (GO:0072600)2.29587292
79retrograde transport, vesicle recycling within Golgi (GO:0000301)2.28843113
80negative regulation of cell cycle G2/M phase transition (GO:1902750)2.27766516
81protein export from nucleus (GO:0006611)2.27022202
82peptidyl-threonine dephosphorylation (GO:0035970)2.26156597
83positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.26092087
84regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.26092087
85regulation of histone H3-K27 methylation (GO:0061085)2.26057707
86protein localization to chromosome, centromeric region (GO:0071459)2.25933191
87protein targeting to Golgi (GO:0000042)2.24859890
88osteoclast differentiation (GO:0030316)2.24694669
89negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.23823300
90response to lipoprotein particle (GO:0055094)2.21556710
91negative regulation of chromatin modification (GO:1903309)2.21165754
92positive regulation of humoral immune response (GO:0002922)2.19829925
93centrosome localization (GO:0051642)2.19650434
94regulation of glucocorticoid metabolic process (GO:0031943)2.18920501
95positive regulation of macroautophagy (GO:0016239)2.18653524
96neural tube formation (GO:0001841)2.17726902
97spermatid nucleus differentiation (GO:0007289)2.16635592
98spleen development (GO:0048536)2.16587486
99regulation of establishment of cell polarity (GO:2000114)2.16290041
100positive regulation of mRNA catabolic process (GO:0061014)2.15862396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.74995017
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.22371968
3E2F7_22180533_ChIP-Seq_HELA_Human3.92501257
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85861050
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.51487560
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05528292
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.00662337
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.00282520
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.92084855
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.82887292
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.75671412
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.68577698
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47319464
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44998139
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28513124
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.08776905
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07761938
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86365862
19GATA1_22025678_ChIP-Seq_K562_Human1.84836678
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79670263
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69072908
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64935705
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62761641
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58879821
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57688779
26BRD4_25478319_ChIP-Seq_HGPS_Human1.56863985
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55457896
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52197637
29TP53_16413492_ChIP-PET_HCT116_Human1.51300205
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45144874
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44806564
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43193375
33AR_21909140_ChIP-Seq_LNCAP_Human1.41522291
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40422689
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38590199
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37623022
37TFEB_21752829_ChIP-Seq_HELA_Human1.37466729
38MYB_26560356_Chip-Seq_TH1_Human1.37223398
39ELK1_19687146_ChIP-ChIP_HELA_Human1.36240530
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35573430
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35573430
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34344883
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32817472
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32305162
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30805516
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30585578
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.30365050
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28653214
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22443638
50MYB_26560356_Chip-Seq_TH2_Human1.21895589
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20958659
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19380550
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19380550
54FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18823836
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16485572
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15605885
57RUNX_20019798_ChIP-Seq_JUKART_Human1.15491706
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15128132
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12268716
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10805543
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.10489312
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09342832
63* VDR_23849224_ChIP-Seq_CD4+_Human1.07898454
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.06484111
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05610390
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05055064
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04338110
68PU_27001747_Chip-Seq_BMDM_Mouse1.03492682
69EWS_26573619_Chip-Seq_HEK293_Human1.03411042
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03233618
71SCL_19346495_ChIP-Seq_HPC-7_Human1.02174171
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.01872701
73NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01836615
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00885198
75AHR_22903824_ChIP-Seq_MCF-7_Human0.99213518
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98968732
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98856768
78MYC_22102868_ChIP-Seq_BL_Human0.98216479
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97255455
80IRF8_27001747_Chip-Seq_BMDM_Mouse0.96970309
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.96202167
82IRF8_22096565_ChIP-ChIP_GC-B_Human0.95615139
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93147344
84BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92839244
85CHD1_26751641_Chip-Seq_LNCaP_Human0.92181019
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91058146
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91027182
88TP53_18474530_ChIP-ChIP_U2OS_Human0.89878800
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89516651
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88583147
91SMAD4_21799915_ChIP-Seq_A2780_Human0.88002079
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87055211
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.84785855
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82702657
95STAT3_23295773_ChIP-Seq_U87_Human0.82533316
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82293012
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81924560
98STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81861945
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81132902
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.81009621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.46834458
2MP0002009_preneoplasia3.56872286
3MP0010352_gastrointestinal_tract_polyps3.55326722
4MP0000569_abnormal_digit_pigmentation3.11075907
5MP0003890_abnormal_embryonic-extraembry2.67746712
6MP0010234_abnormal_vibrissa_follicle2.50002053
7MP0003656_abnormal_erythrocyte_physiolo2.43835858
8MP0005076_abnormal_cell_differentiation2.22857159
9MP0002166_altered_tumor_susceptibility2.22145494
10MP0003091_abnormal_cell_migration2.17233305
11MP0003221_abnormal_cardiomyocyte_apopto2.01905398
12MP0004808_abnormal_hematopoietic_stem1.99744475
13MP0003077_abnormal_cell_cycle1.97551029
14MP0009697_abnormal_copulation1.94791265
15MP0003763_abnormal_thymus_physiology1.84562390
16MP0006054_spinal_hemorrhage1.82579045
17MP0010307_abnormal_tumor_latency1.81927520
18MP0002006_tumorigenesis1.80058948
19MP0001915_intracranial_hemorrhage1.76575509
20MP0002396_abnormal_hematopoietic_system1.61741493
21MP0003111_abnormal_nucleus_morphology1.60621872
22MP0003950_abnormal_plasma_membrane1.59215550
23MP0003984_embryonic_growth_retardation1.59020434
24MP0010094_abnormal_chromosome_stability1.57269747
25MP0002088_abnormal_embryonic_growth/wei1.53960744
26MP0005380_embryogenesis_phenotype1.53898000
27MP0001672_abnormal_embryogenesis/_devel1.53898000
28MP0008007_abnormal_cellular_replicative1.52172069
29MP0010678_abnormal_skin_adnexa1.46810877
30MP0001661_extended_life_span1.42411519
31MP0005397_hematopoietic_system_phenotyp1.41250134
32MP0001545_abnormal_hematopoietic_system1.41250134
33MP0003786_premature_aging1.41168269
34MP0002086_abnormal_extraembryonic_tissu1.40053565
35MP0003300_gastrointestinal_ulcer1.39010438
36MP0003828_pulmonary_edema1.37918767
37MP0009278_abnormal_bone_marrow1.29801887
38MP0001879_abnormal_lymphatic_vessel1.29689987
39MP0000350_abnormal_cell_proliferation1.23836034
40MP0005621_abnormal_cell_physiology1.21224346
41MP0004957_abnormal_blastocyst_morpholog1.20974611
42MP0000465_gastrointestinal_hemorrhage1.14519881
43MP0002332_abnormal_exercise_endurance1.12152709
44MP0004185_abnormal_adipocyte_glucose1.11129549
45MP0001730_embryonic_growth_arrest1.09835254
46MP0003453_abnormal_keratinocyte_physiol1.06260148
47MP0002084_abnormal_developmental_patter1.05777524
48MP0008961_abnormal_basal_metabolism1.03183146
49MP0008058_abnormal_DNA_repair1.03102968
50MP0001697_abnormal_embryo_size1.01957271
51MP0000537_abnormal_urethra_morphology0.99528211
52MP0003191_abnormal_cellular_cholesterol0.99494707
53MP0004272_abnormal_basement_membrane0.98891424
54MP0003566_abnormal_cell_adhesion0.98724625
55MP0000383_abnormal_hair_follicle0.98374530
56MP0005187_abnormal_penis_morphology0.97986514
57MP0005384_cellular_phenotype0.94453264
58MP0004197_abnormal_fetal_growth/weight/0.94321585
59MP0003303_peritoneal_inflammation0.93806237
60MP0005451_abnormal_body_composition0.93349613
61MP0000733_abnormal_muscle_development0.92172100
62MP0000703_abnormal_thymus_morphology0.91587792
63MP0002080_prenatal_lethality0.89778251
64MP0002398_abnormal_bone_marrow0.89745865
65MP0008260_abnormal_autophagy0.87836489
66MP0003705_abnormal_hypodermis_morpholog0.85650817
67MP0005310_abnormal_salivary_gland0.84437268
68MP0003718_maternal_effect0.84215211
69MP0002722_abnormal_immune_system0.83557142
70MP0004947_skin_inflammation0.80315626
71MP0003868_abnormal_feces_composition0.80131114
72MP0000689_abnormal_spleen_morphology0.80013342
73MP0002925_abnormal_cardiovascular_devel0.79853041
74MP0000015_abnormal_ear_pigmentation0.78656761
75MP0000432_abnormal_head_morphology0.77820327
76MP0003935_abnormal_craniofacial_develop0.76076613
77MP0004233_abnormal_muscle_weight0.75503868
78MP0000313_abnormal_cell_death0.75141720
79MP0001191_abnormal_skin_condition0.74579595
80MP0003941_abnormal_skin_development0.74315173
81MP0005275_abnormal_skin_tensile0.73794852
82MP0002019_abnormal_tumor_incidence0.73330803
83MP0002269_muscular_atrophy0.73034949
84MP0005266_abnormal_metabolism0.72995632
85MP0002085_abnormal_embryonic_tissue0.72844335
86MP0002405_respiratory_system_inflammati0.72742437
87MP0009703_decreased_birth_body0.70337016
88MP0001727_abnormal_embryo_implantation0.67951864
89MP0008995_early_reproductive_senescence0.67389444
90MP0005623_abnormal_meninges_morphology0.67377198
91MP0001851_eye_inflammation0.67261035
92MP0005395_other_phenotype0.66739101
93MP0000428_abnormal_craniofacial_morphol0.66365199
94MP0000013_abnormal_adipose_tissue0.64905854
95MP0000759_abnormal_skeletal_muscle0.64666837
96MP0002128_abnormal_blood_circulation0.64298507
97MP0004510_myositis0.64188429
98MP0001216_abnormal_epidermal_layer0.63747387
99MP0003693_abnormal_embryo_hatching0.61506585
100MP0005023_abnormal_wound_healing0.61353613

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.88551209
2Subacute progressive viral hepatitis (HP:0006572)3.17337261
3Thyroid carcinoma (HP:0002890)3.12695688
4Heterotopia (HP:0002282)3.06396742
5Acute myeloid leukemia (HP:0004808)2.98639654
6Large earlobe (HP:0009748)2.90281329
7Arterial tortuosity (HP:0005116)2.88397353
8Abnormality of the fingertips (HP:0001211)2.76995141
9Truncal obesity (HP:0001956)2.76347056
10Long eyelashes (HP:0000527)2.74772562
11Deep philtrum (HP:0002002)2.73043080
12T lymphocytopenia (HP:0005403)2.69861934
13Narrow palate (HP:0000189)2.56906361
14Entropion (HP:0000621)2.52245168
15Fatigue (HP:0012378)2.51857487
16IgA deficiency (HP:0002720)2.49236006
17Pelvic girdle muscle weakness (HP:0003749)2.46102828
18Overgrowth (HP:0001548)2.39762651
19Medulloblastoma (HP:0002885)2.36669890
20Abnormality of the columella (HP:0009929)2.36074654
21Abnormality of chromosome stability (HP:0003220)2.35551631
22Abnormality of the hip-girdle musculature (HP:0001445)2.35275756
23Abnormality of the musculature of the pelvis (HP:0001469)2.35275756
24IgM deficiency (HP:0002850)2.34394114
25Vascular tortuosity (HP:0004948)2.26850965
26Syringomyelia (HP:0003396)2.26776614
27Spinal cord lesions (HP:0100561)2.26776614
28Thickened calvaria (HP:0002684)2.26312060
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26307841
30Dysmetric saccades (HP:0000641)2.26218124
31Abnormality of T cell number (HP:0011839)2.23233116
32Neonatal hypoglycemia (HP:0001998)2.21561006
33Prominent nose (HP:0000448)2.18685482
34Menstrual irregularities (HP:0000858)2.13823796
35Hematochezia (HP:0002573)2.10506615
36Dislocated radial head (HP:0003083)2.10155413
37Abnormality of the phalanges of the hallux (HP:0010057)2.09855045
38Capillary hemangiomas (HP:0005306)2.08775417
39Embryonal renal neoplasm (HP:0011794)2.07389748
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.07265072
41Progressive external ophthalmoplegia (HP:0000590)2.05558989
42Spondylolisthesis (HP:0003302)2.04586074
43Nephroblastoma (Wilms tumor) (HP:0002667)2.01623335
44Abnormal foot bone ossification (HP:0010675)2.01325333
45Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.00359458
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00351461
47Viral hepatitis (HP:0006562)1.98586015
48Anhidrosis (HP:0000970)1.98417164
49Abnormality of the epiphyses of the hand (HP:0005924)1.96828822
50Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.96465324
51Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.96263039
52Fair hair (HP:0002286)1.96158449
53Abnormality of DNA repair (HP:0003254)1.92818499
54Anal stenosis (HP:0002025)1.87895560
55Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.86428390
56Submucous cleft hard palate (HP:0000176)1.83860690
57Ectropion (HP:0000656)1.82897451
58Broad ribs (HP:0000885)1.81807767
59Lower limb hyperreflexia (HP:0002395)1.80835330
60Abnormality of the radial head (HP:0003995)1.79353367
61Chromsome breakage (HP:0040012)1.79207800
62Hypoplastic labia majora (HP:0000059)1.79107583
63Abnormality of the labia majora (HP:0012881)1.78064303
64Aortic aneurysm (HP:0004942)1.75754514
65Overlapping toe (HP:0001845)1.75399657
66Colitis (HP:0002583)1.75179541
67Bladder neoplasm (HP:0009725)1.74283812
68Bladder carcinoma (HP:0002862)1.74283812
69Aplasia/Hypoplasia of the uvula (HP:0010293)1.74145464
70Long clavicles (HP:0000890)1.73787229
71Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73653306
72Hypergonadotropic hypogonadism (HP:0000815)1.73520239
73Relative macrocephaly (HP:0004482)1.73323320
74Subaortic stenosis (HP:0001682)1.72856225
75Abnormality of the left ventricular outflow tract (HP:0011103)1.72856225
76Abnormality of incisor morphology (HP:0011063)1.72664415
77Aortic dissection (HP:0002647)1.71959974
78Transitional cell carcinoma of the bladder (HP:0006740)1.71542943
79Cystic hygroma (HP:0000476)1.71455075
80Increased number of teeth (HP:0011069)1.70365946
81Curly hair (HP:0002212)1.69464323
82Conjunctival telangiectasia (HP:0000524)1.68536164
83Recurrent viral infections (HP:0004429)1.67844980
84Knee flexion contracture (HP:0006380)1.62981063
85Tetraparesis (HP:0002273)1.62099792
86Acute lymphatic leukemia (HP:0006721)1.60899886
87Facial diplegia (HP:0001349)1.60646890
88Micronodular cirrhosis (HP:0001413)1.60015682
89Low anterior hairline (HP:0000294)1.59823177
90Bicuspid aortic valve (HP:0001647)1.59633545
91Osteolytic defects of the hand bones (HP:0009699)1.59587310
92Osteolytic defects of the phalanges of the hand (HP:0009771)1.59587310
93Asymmetry of the thorax (HP:0001555)1.59454232
94Volvulus (HP:0002580)1.59072248
95Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59051670
96Uterine leiomyosarcoma (HP:0002891)1.58967293
97Leiomyosarcoma (HP:0100243)1.58967293
98Macroorchidism (HP:0000053)1.58503797
99Periodontitis (HP:0000704)1.58468785
100Dilatation of the ascending aorta (HP:0005111)1.57661392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD43.85466473
2CDK123.35704636
3EIF2AK33.18926963
4PRPF4B2.62474491
5AKT32.57010257
6MAP3K102.34169554
7CAMK1D2.10527236
8LATS12.04755769
9EPHA31.99544439
10STK101.92733552
11IRAK21.90378371
12IRAK11.82440267
13SCYL21.78442280
14MELK1.77488670
15OBSCN1.72991983
16EEF2K1.68710931
17SGK21.62674400
18NLK1.59859742
19BRSK21.58981391
20MAP3K141.50656382
21EIF2AK11.50340208
22FGFR31.46935035
23NEK91.35580816
24CAMK1G1.34482878
25DYRK31.34069229
26IKBKE1.33252873
27NUAK11.33248601
28SGK31.31583269
29TRPM71.29122290
30ERBB31.28527588
31MKNK21.26934433
32PIK3CG1.23669253
33RAF11.19000357
34PIM11.18794541
35ACVR1B1.17413138
36MST41.15132612
37TEC1.13881405
38JAK11.12637149
39ZAK1.11825265
40FRK1.09228878
41TGFBR21.09045631
42WNK11.06935974
43TAOK31.04589805
44CDK61.03799843
45MAP2K71.01490516
46CHUK0.97696966
47MTOR0.97313103
48STK240.95853305
49MAP3K40.95258449
50YES10.95073861
51CHEK10.93662212
52FLT30.86566684
53CAMKK20.86152351
54PDGFRB0.83094937
55STK40.80660884
56TTN0.79288905
57STK30.78092396
58RPS6KA50.75030186
59PBK0.74184650
60MAP3K60.72621604
61MARK20.72468905
62MAP2K30.71675543
63ATM0.71508185
64MET0.70376105
65CAMK40.69482086
66JAK30.68857114
67CDK90.68511236
68TTK0.65638773
69PRKAA20.64725133
70STK38L0.64305224
71PDGFRA0.63777712
72MAPK110.62545142
73NEK60.62462587
74MAP3K130.60920017
75MAP3K30.58640290
76MARK30.58640076
77SGK4940.58033854
78SGK2230.58033854
79MAP3K70.56569034
80MAP3K50.56454047
81SRPK10.55436680
82RET0.52857874
83MAP3K10.51786031
84ERBB40.50302942
85KSR10.49846354
86IRAK40.48749059
87RPS6KA40.48705604
88BTK0.47064858
89EIF2AK20.46501701
90ATR0.45875907
91MAP3K80.45465980
92RPS6KB10.44466219
93PRKAA10.44104593
94AURKB0.43597354
95CDK20.42574038
96MAP3K20.42448298
97RPS6KB20.42211489
98CHEK20.41751585
99JAK20.41565091
100BRAF0.41144748

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053222.36330971
2Alcoholism_Homo sapiens_hsa050341.88411150
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76005743
4Viral carcinogenesis_Homo sapiens_hsa052031.72473928
5Dorso-ventral axis formation_Homo sapiens_hsa043201.72235274
6Chronic myeloid leukemia_Homo sapiens_hsa052201.69751547
7Non-small cell lung cancer_Homo sapiens_hsa052231.67400933
8MicroRNAs in cancer_Homo sapiens_hsa052061.66567924
9FoxO signaling pathway_Homo sapiens_hsa040681.63588455
10Endometrial cancer_Homo sapiens_hsa052131.62321876
11Pancreatic cancer_Homo sapiens_hsa052121.61664697
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.60632647
13Colorectal cancer_Homo sapiens_hsa052101.57984249
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57095813
15Acute myeloid leukemia_Homo sapiens_hsa052211.56839593
16Thyroid cancer_Homo sapiens_hsa052161.55313844
17B cell receptor signaling pathway_Homo sapiens_hsa046621.54142414
18Cell cycle_Homo sapiens_hsa041101.53671851
19p53 signaling pathway_Homo sapiens_hsa041151.51134228
20Prostate cancer_Homo sapiens_hsa052151.50952322
21Prolactin signaling pathway_Homo sapiens_hsa049171.50948170
22Hepatitis B_Homo sapiens_hsa051611.49906976
23Non-homologous end-joining_Homo sapiens_hsa034501.47423074
24Circadian rhythm_Homo sapiens_hsa047101.45959602
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.44589006
26Measles_Homo sapiens_hsa051621.44104280
27Inositol phosphate metabolism_Homo sapiens_hsa005621.44062999
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40783993
29Renal cell carcinoma_Homo sapiens_hsa052111.40524974
30Adherens junction_Homo sapiens_hsa045201.37744925
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36929697
32Small cell lung cancer_Homo sapiens_hsa052221.35496657
33TGF-beta signaling pathway_Homo sapiens_hsa043501.33245407
34mTOR signaling pathway_Homo sapiens_hsa041501.33107007
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30481386
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.27790336
37Herpes simplex infection_Homo sapiens_hsa051681.25430607
38T cell receptor signaling pathway_Homo sapiens_hsa046601.24925606
39Basal transcription factors_Homo sapiens_hsa030221.24811235
40TNF signaling pathway_Homo sapiens_hsa046681.21522543
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21373242
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19703925
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16510382
44Apoptosis_Homo sapiens_hsa042101.15857601
45Osteoclast differentiation_Homo sapiens_hsa043801.15754817
46mRNA surveillance pathway_Homo sapiens_hsa030151.13760335
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.13713966
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11068043
49ErbB signaling pathway_Homo sapiens_hsa040121.11038666
50RNA transport_Homo sapiens_hsa030131.08046865
51Influenza A_Homo sapiens_hsa051641.05290870
52Proteoglycans in cancer_Homo sapiens_hsa052051.01727893
53Fanconi anemia pathway_Homo sapiens_hsa034601.01648477
54Glioma_Homo sapiens_hsa052141.00557534
55Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00303538
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00130552
57RNA degradation_Homo sapiens_hsa030180.98353959
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98138172
59Epstein-Barr virus infection_Homo sapiens_hsa051690.96018639
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95101913
61Regulation of autophagy_Homo sapiens_hsa041400.93978342
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93159051
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92241944
64Toxoplasmosis_Homo sapiens_hsa051450.90289251
65Hepatitis C_Homo sapiens_hsa051600.89338120
66Insulin resistance_Homo sapiens_hsa049310.85550904
67HIF-1 signaling pathway_Homo sapiens_hsa040660.84926578
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84357509
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.83283508
70Focal adhesion_Homo sapiens_hsa045100.81219768
71Insulin signaling pathway_Homo sapiens_hsa049100.80859771
72HTLV-I infection_Homo sapiens_hsa051660.80787050
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77035436
74Lysine degradation_Homo sapiens_hsa003100.76690091
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74946130
76Platelet activation_Homo sapiens_hsa046110.74848404
77Pathways in cancer_Homo sapiens_hsa052000.73643245
78Choline metabolism in cancer_Homo sapiens_hsa052310.72363033
79Type II diabetes mellitus_Homo sapiens_hsa049300.71770681
80Legionellosis_Homo sapiens_hsa051340.70756878
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69106416
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.67087974
83Sphingolipid metabolism_Homo sapiens_hsa006000.64167959
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.62372527
85Oocyte meiosis_Homo sapiens_hsa041140.62216684
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60602400
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59022448
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.58968100
89Nucleotide excision repair_Homo sapiens_hsa034200.57734549
90Melanoma_Homo sapiens_hsa052180.56432036
91MAPK signaling pathway_Homo sapiens_hsa040100.53541961
92AMPK signaling pathway_Homo sapiens_hsa041520.52768909
93Leishmaniasis_Homo sapiens_hsa051400.52114083
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51436796
95Wnt signaling pathway_Homo sapiens_hsa043100.49267028
96Hippo signaling pathway_Homo sapiens_hsa043900.49211479
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48174835
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.47575730
99Malaria_Homo sapiens_hsa051440.45301572
100Shigellosis_Homo sapiens_hsa051310.44968770

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