ZNF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.60558257
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.12814492
3regulation of translation, ncRNA-mediated (GO:0045974)4.12814492
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.12814492
5L-fucose catabolic process (GO:0042355)3.96337979
6fucose catabolic process (GO:0019317)3.96337979
7L-fucose metabolic process (GO:0042354)3.96337979
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74879884
9response to pheromone (GO:0019236)3.72028877
10kidney morphogenesis (GO:0060993)3.58449769
11regulation of gene silencing by RNA (GO:0060966)3.57949520
12regulation of posttranscriptional gene silencing (GO:0060147)3.57949520
13regulation of gene silencing by miRNA (GO:0060964)3.57949520
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36662415
15tryptophan catabolic process (GO:0006569)3.29992528
16indole-containing compound catabolic process (GO:0042436)3.29992528
17indolalkylamine catabolic process (GO:0046218)3.29992528
18regulation of nuclear cell cycle DNA replication (GO:0033262)3.29694972
19indolalkylamine metabolic process (GO:0006586)3.29512156
20kynurenine metabolic process (GO:0070189)3.28860011
21neural tube formation (GO:0001841)3.23915151
22negative regulation of telomere maintenance (GO:0032205)3.15989759
23behavioral response to ethanol (GO:0048149)3.15220663
24gamma-aminobutyric acid transport (GO:0015812)3.12453551
25pyrimidine nucleobase catabolic process (GO:0006208)2.99092927
26regulation of telomere maintenance (GO:0032204)2.98702276
27nonmotile primary cilium assembly (GO:0035058)2.97240765
28epithelial cilium movement (GO:0003351)2.94066152
29tryptophan metabolic process (GO:0006568)2.92886542
30protein K11-linked deubiquitination (GO:0035871)2.90108654
31protein polyglutamylation (GO:0018095)2.89294901
32negative regulation of DNA-dependent DNA replication (GO:2000104)2.88815181
33neuronal action potential (GO:0019228)2.84268359
34somite development (GO:0061053)2.81487862
35negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79668661
36spinal cord motor neuron differentiation (GO:0021522)2.76589466
37water-soluble vitamin biosynthetic process (GO:0042364)2.76523470
38cornea development in camera-type eye (GO:0061303)2.76260097
39presynaptic membrane assembly (GO:0097105)2.74711380
40regulation of hippo signaling (GO:0035330)2.74117439
41replication fork processing (GO:0031297)2.72531748
42sulfation (GO:0051923)2.70476315
43atrial cardiac muscle cell action potential (GO:0086014)2.66923060
44indole-containing compound metabolic process (GO:0042430)2.66367778
45axoneme assembly (GO:0035082)2.65563688
46rRNA catabolic process (GO:0016075)2.65144689
47piRNA metabolic process (GO:0034587)2.63607858
48detection of light stimulus involved in sensory perception (GO:0050962)2.63414376
49detection of light stimulus involved in visual perception (GO:0050908)2.63414376
50cilium or flagellum-dependent cell motility (GO:0001539)2.59358530
51DNA deamination (GO:0045006)2.58412583
52regulation of action potential (GO:0098900)2.57944844
53reflex (GO:0060004)2.57119079
54reciprocal meiotic recombination (GO:0007131)2.57113763
55reciprocal DNA recombination (GO:0035825)2.57113763
56cilium organization (GO:0044782)2.55589403
57recombinational repair (GO:0000725)2.55504376
58double-strand break repair via homologous recombination (GO:0000724)2.54985752
59primary amino compound metabolic process (GO:1901160)2.54659321
60transmission of nerve impulse (GO:0019226)2.54388826
61negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53662433
62positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.53299493
63regulation of mesoderm development (GO:2000380)2.51941841
64cilium assembly (GO:0042384)2.49578346
65cilium movement (GO:0003341)2.49531668
66retinal cone cell development (GO:0046549)2.49500305
67serotonin metabolic process (GO:0042428)2.48768931
68cellular ketone body metabolic process (GO:0046950)2.47785971
69nucleobase catabolic process (GO:0046113)2.47428919
70inner ear receptor stereocilium organization (GO:0060122)2.47258852
71synaptic transmission, cholinergic (GO:0007271)2.47092843
72presynaptic membrane organization (GO:0097090)2.46998153
73cilium morphogenesis (GO:0060271)2.46220877
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46122994
75meiotic chromosome segregation (GO:0045132)2.45742581
76hindbrain development (GO:0030902)2.45539070
77RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44605867
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43965386
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43040066
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.43040066
81NADH dehydrogenase complex assembly (GO:0010257)2.43040066
82nephron tubule morphogenesis (GO:0072078)2.41934394
83nephron epithelium morphogenesis (GO:0072088)2.41934394
84head development (GO:0060322)2.41906191
85preassembly of GPI anchor in ER membrane (GO:0016254)2.40724980
86histone H3-K9 methylation (GO:0051567)2.39608323
87startle response (GO:0001964)2.39089102
88appendage development (GO:0048736)2.38618191
89limb development (GO:0060173)2.38618191
90cAMP catabolic process (GO:0006198)2.38003438
91limb bud formation (GO:0060174)2.34964517
92regulation of rhodopsin mediated signaling pathway (GO:0022400)2.33152065
93positive regulation of oligodendrocyte differentiation (GO:0048714)2.32556674
94postsynaptic membrane organization (GO:0001941)2.31822376
95neuron cell-cell adhesion (GO:0007158)2.30931452
96photoreceptor cell development (GO:0042461)2.29978978
97forebrain neuron differentiation (GO:0021879)2.29891012
98DNA demethylation (GO:0080111)2.29026909
99signal peptide processing (GO:0006465)2.28388993
100photoreceptor cell maintenance (GO:0045494)2.28278721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.84868548
2EZH2_22144423_ChIP-Seq_EOC_Human3.41395953
3VDR_22108803_ChIP-Seq_LS180_Human3.20489396
4GBX2_23144817_ChIP-Seq_PC3_Human3.10381481
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07026142
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.66419858
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53849229
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36668208
9IGF1R_20145208_ChIP-Seq_DFB_Human2.33911304
10FUS_26573619_Chip-Seq_HEK293_Human2.32077980
11EWS_26573619_Chip-Seq_HEK293_Human2.32007917
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29950564
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28165369
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14492495
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06481429
16TAF15_26573619_Chip-Seq_HEK293_Human2.05948237
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00762010
18* P300_19829295_ChIP-Seq_ESCs_Human1.98148731
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97865305
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91481399
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91310830
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.90182919
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84335687
24ER_23166858_ChIP-Seq_MCF-7_Human1.81461482
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79850829
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79850829
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77401350
28AR_21572438_ChIP-Seq_LNCaP_Human1.71349352
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.70203787
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66767342
31STAT3_23295773_ChIP-Seq_U87_Human1.66558156
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64568368
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.63364549
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.62461489
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59650443
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56364619
37IRF1_19129219_ChIP-ChIP_H3396_Human1.56187754
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55397028
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.54350500
40REST_21632747_ChIP-Seq_MESCs_Mouse1.51920389
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50407579
42SMAD4_21799915_ChIP-Seq_A2780_Human1.50163152
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49711364
44TCF4_23295773_ChIP-Seq_U87_Human1.49569164
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48894123
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46410476
47BCAT_22108803_ChIP-Seq_LS180_Human1.45955598
48RNF2_27304074_Chip-Seq_NSC_Mouse1.44785333
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44436905
50MYC_18940864_ChIP-ChIP_HL60_Human1.43760092
51CBP_20019798_ChIP-Seq_JUKART_Human1.40481156
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40481156
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39569186
54AR_25329375_ChIP-Seq_VCAP_Human1.38079451
55TP53_22573176_ChIP-Seq_HFKS_Human1.37149583
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35585438
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35280086
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.32481087
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29629296
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29584580
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29518622
62RUNX2_22187159_ChIP-Seq_PCA_Human1.23557762
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19219037
64TCF4_22108803_ChIP-Seq_LS180_Human1.19133719
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19055298
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16099051
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15925042
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.15576510
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.15502118
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.14399465
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14395701
72NANOG_19829295_ChIP-Seq_ESCs_Human1.13560487
73SOX2_19829295_ChIP-Seq_ESCs_Human1.13560487
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12335415
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06879387
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05776308
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.05776308
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05265863
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05009015
80* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04212854
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.00216532
82GABP_17652178_ChIP-ChIP_JURKAT_Human0.99837021
83PRDM14_20953172_ChIP-Seq_ESCs_Human0.99491920
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99183570
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98821913
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.98536458
87EED_16625203_ChIP-ChIP_MESCs_Mouse0.97763520
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97756803
89SOX2_21211035_ChIP-Seq_LN229_Gbm0.97680888
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.96391957
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95926000
92HOXB7_26014856_ChIP-Seq_BT474_Human0.95756894
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.94729079
94DROSHA_22980978_ChIP-Seq_HELA_Human0.94233362
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92924230
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92671137
97ELK1_19687146_ChIP-ChIP_HELA_Human0.92596690
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92355198
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.92243619
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92128549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.12892328
2MP0000569_abnormal_digit_pigmentation2.86310301
3MP0006292_abnormal_olfactory_placode2.61646619
4MP0003136_yellow_coat_color2.44602902
5MP0002102_abnormal_ear_morphology2.38372655
6MP0002638_abnormal_pupillary_reflex2.25207152
7MP0003787_abnormal_imprinting2.21542628
8MP0005551_abnormal_eye_electrophysiolog2.15140152
9MP0009046_muscle_twitch2.04031459
10MP0003195_calcinosis1.99371712
11MP0001968_abnormal_touch/_nociception1.94605778
12MP0004133_heterotaxia1.90800097
13MP0006072_abnormal_retinal_apoptosis1.88390930
14MP0003646_muscle_fatigue1.87897083
15MP0000631_abnormal_neuroendocrine_gland1.85730224
16MP0005645_abnormal_hypothalamus_physiol1.85120312
17MP0009745_abnormal_behavioral_response1.82733126
18MP0003890_abnormal_embryonic-extraembry1.82237356
19MP0003880_abnormal_central_pattern1.78978963
20MP0002938_white_spotting1.78853242
21MP0004142_abnormal_muscle_tone1.74994961
22MP0005646_abnormal_pituitary_gland1.72025778
23MP0008057_abnormal_DNA_replication1.68001369
24MP0001486_abnormal_startle_reflex1.65686945
25MP0002837_dystrophic_cardiac_calcinosis1.64322215
26MP0000778_abnormal_nervous_system1.62904196
27MP0001485_abnormal_pinna_reflex1.59435871
28MP0001986_abnormal_taste_sensitivity1.58272336
29MP0008872_abnormal_physiological_respon1.57032968
30MP0002736_abnormal_nociception_after1.54006812
31MP0006276_abnormal_autonomic_nervous1.53569796
32MP0004043_abnormal_pH_regulation1.53116470
33MP0005253_abnormal_eye_physiology1.52903041
34MP0002272_abnormal_nervous_system1.49161234
35MP0004147_increased_porphyrin_level1.48290152
36MP0004885_abnormal_endolymph1.46534695
37MP0000427_abnormal_hair_cycle1.45754454
38MP0002928_abnormal_bile_duct1.42677659
39MP0001293_anophthalmia1.41185836
40MP0005174_abnormal_tail_pigmentation1.39742391
41MP0002653_abnormal_ependyma_morphology1.36875524
42MP0001501_abnormal_sleep_pattern1.36216313
43MP0002735_abnormal_chemical_nociception1.34514585
44MP0002064_seizures1.34094742
45MP0003119_abnormal_digestive_system1.30605514
46MP0002557_abnormal_social/conspecific_i1.26600780
47MP0002572_abnormal_emotion/affect_behav1.25288376
48MP0004742_abnormal_vestibular_system1.23702798
49MP0003635_abnormal_synaptic_transmissio1.21561766
50MP0003937_abnormal_limbs/digits/tail_de1.20799654
51MP0002160_abnormal_reproductive_system1.20729537
52MP0002876_abnormal_thyroid_physiology1.20627228
53MP0008058_abnormal_DNA_repair1.19756638
54MP0008995_early_reproductive_senescence1.19361011
55MP0003121_genomic_imprinting1.17054417
56MP0000383_abnormal_hair_follicle1.16396198
57MP0000372_irregular_coat_pigmentation1.14885827
58MP0004145_abnormal_muscle_electrophysio1.13514819
59MP0001984_abnormal_olfaction1.11559383
60MP0002751_abnormal_autonomic_nervous1.11383381
61MP0004924_abnormal_behavior1.11191473
62MP0005386_behavior/neurological_phenoty1.11191473
63MP0002063_abnormal_learning/memory/cond1.10145796
64MP0001970_abnormal_pain_threshold1.09308882
65MP0005195_abnormal_posterior_eye1.08717100
66MP0002067_abnormal_sensory_capabilities1.07041379
67MP0002733_abnormal_thermal_nociception1.06503177
68MP0003122_maternal_imprinting1.04376355
69MP0002234_abnormal_pharynx_morphology1.03968140
70MP0008961_abnormal_basal_metabolism1.02992328
71MP0002752_abnormal_somatic_nervous1.01635527
72MP0005084_abnormal_gallbladder_morpholo1.01324100
73MP0002734_abnormal_mechanical_nocicepti1.00989179
74MP0002184_abnormal_innervation1.00511203
75MP0001188_hyperpigmentation0.98776284
76MP0003283_abnormal_digestive_organ0.98532769
77MP0000955_abnormal_spinal_cord0.97909429
78MP0003567_abnormal_fetal_cardiomyocyte0.92781224
79MP0005389_reproductive_system_phenotype0.92382104
80MP0002095_abnormal_skin_pigmentation0.92173766
81MP0001529_abnormal_vocalization0.91998244
82MP0005391_vision/eye_phenotype0.90815752
83MP0003011_delayed_dark_adaptation0.90627442
84MP0001286_abnormal_eye_development0.89962252
85MP0001324_abnormal_eye_pigmentation0.89546561
86MP0003698_abnormal_male_reproductive0.88985561
87MP0001502_abnormal_circadian_rhythm0.87227821
88MP0003718_maternal_effect0.86483956
89MP0002882_abnormal_neuron_morphology0.85876427
90MP0000049_abnormal_middle_ear0.85704291
91MP0003137_abnormal_impulse_conducting0.84076743
92MP0003861_abnormal_nervous_system0.83478036
93MP0000026_abnormal_inner_ear0.82320569
94MP0002210_abnormal_sex_determination0.81984502
95MP0005423_abnormal_somatic_nervous0.81559367
96MP0003878_abnormal_ear_physiology0.78289728
97MP0005377_hearing/vestibular/ear_phenot0.78289728
98MP0002152_abnormal_brain_morphology0.77955519
99MP0001929_abnormal_gametogenesis0.76855265
100MP0001963_abnormal_hearing_physiology0.75077152

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.22411574
2Abnormality of midbrain morphology (HP:0002418)3.78703227
3Molar tooth sign on MRI (HP:0002419)3.78703227
4Pancreatic fibrosis (HP:0100732)3.77154323
5Hyperventilation (HP:0002883)3.63983363
6True hermaphroditism (HP:0010459)3.60894525
7Nephronophthisis (HP:0000090)3.60377110
8Type II lissencephaly (HP:0007260)3.37447971
9Congenital stationary night blindness (HP:0007642)3.30001352
10Genetic anticipation (HP:0003743)3.12698790
11Abnormality of the renal medulla (HP:0100957)3.11075672
12Progressive cerebellar ataxia (HP:0002073)2.94165830
13Abnormality of the renal cortex (HP:0011035)2.80743515
14Lissencephaly (HP:0001339)2.78747548
15Birth length less than 3rd percentile (HP:0003561)2.78263560
16Medial flaring of the eyebrow (HP:0010747)2.69157429
17Gaze-evoked nystagmus (HP:0000640)2.68576004
18Protruding tongue (HP:0010808)2.67409238
19Chronic hepatic failure (HP:0100626)2.61649188
20Cystic liver disease (HP:0006706)2.61264566
21Pendular nystagmus (HP:0012043)2.58965656
22Patellar aplasia (HP:0006443)2.55590481
23Inability to walk (HP:0002540)2.52720130
24Tubular atrophy (HP:0000092)2.49391261
25Cerebellar dysplasia (HP:0007033)2.48559907
26Broad-based gait (HP:0002136)2.46340113
27Progressive inability to walk (HP:0002505)2.42278419
28Abnormality of the pons (HP:0007361)2.41364648
29Aplasia/Hypoplasia of the patella (HP:0006498)2.40124469
30Attenuation of retinal blood vessels (HP:0007843)2.37348557
31Bilateral microphthalmos (HP:0007633)2.36637749
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36045477
33Abnormality of alanine metabolism (HP:0010916)2.36045477
34Hyperalaninemia (HP:0003348)2.36045477
35Hypoplasia of the pons (HP:0012110)2.34730608
36Abolished electroretinogram (ERG) (HP:0000550)2.34364573
37Anencephaly (HP:0002323)2.26473178
38Gait imbalance (HP:0002141)2.23665956
39Sclerocornea (HP:0000647)2.20258394
40Optic nerve hypoplasia (HP:0000609)2.20188873
41Abnormality of the labia minora (HP:0012880)2.17950064
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15255868
43Polydipsia (HP:0001959)2.15033785
44Abnormal drinking behavior (HP:0030082)2.15033785
45Febrile seizures (HP:0002373)2.13502425
46Large for gestational age (HP:0001520)2.12155028
47Congenital primary aphakia (HP:0007707)2.10938785
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.10605302
49Absent/shortened dynein arms (HP:0200106)2.10605302
50Nephrogenic diabetes insipidus (HP:0009806)2.04822486
51Colon cancer (HP:0003003)2.04415988
52Genital tract atresia (HP:0001827)2.04215088
53Vaginal atresia (HP:0000148)2.01904581
54Chorioretinal atrophy (HP:0000533)2.00574853
55Pachygyria (HP:0001302)1.98722244
56Aplasia/Hypoplasia of the tibia (HP:0005772)1.98559671
57Oligodactyly (hands) (HP:0001180)1.98165669
58Stomach cancer (HP:0012126)1.96898327
59Increased corneal curvature (HP:0100692)1.96436245
60Keratoconus (HP:0000563)1.96436245
61Congenital hepatic fibrosis (HP:0002612)1.96271964
62Bile duct proliferation (HP:0001408)1.95554522
63Abnormal biliary tract physiology (HP:0012439)1.95554522
64Furrowed tongue (HP:0000221)1.95264676
65Small hand (HP:0200055)1.95110450
66Intestinal atresia (HP:0011100)1.93786057
67Aplasia/Hypoplasia of the uvula (HP:0010293)1.93404001
68Decreased circulating renin level (HP:0003351)1.91649536
69Concave nail (HP:0001598)1.91095717
70Fair hair (HP:0002286)1.90943481
71Drooling (HP:0002307)1.90204149
72Poor coordination (HP:0002370)1.89970658
73Partial agenesis of the corpus callosum (HP:0001338)1.89761276
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.88686402
75Dandy-Walker malformation (HP:0001305)1.87771350
76Clumsiness (HP:0002312)1.87727448
77Focal seizures (HP:0007359)1.81480674
78Congenital, generalized hypertrichosis (HP:0004540)1.80288923
79Hemiparesis (HP:0001269)1.75069326
80Focal motor seizures (HP:0011153)1.74851989
81Male pseudohermaphroditism (HP:0000037)1.74450796
82Ectopic kidney (HP:0000086)1.74388095
83Abnormality of the renal collecting system (HP:0004742)1.73880312
84Duplicated collecting system (HP:0000081)1.73818952
85Renal cortical cysts (HP:0000803)1.73724708
86Bony spicule pigmentary retinopathy (HP:0007737)1.71654242
87Widely spaced teeth (HP:0000687)1.70083755
88Volvulus (HP:0002580)1.70048271
89Supernumerary spleens (HP:0009799)1.69952257
90Dialeptic seizures (HP:0011146)1.69591332
91Postaxial foot polydactyly (HP:0001830)1.69344288
92Abnormal respiratory motile cilium morphology (HP:0005938)1.68393558
93Abnormal respiratory epithelium morphology (HP:0012253)1.68393558
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68063828
95Abnormality of the ileum (HP:0001549)1.67551673
96Excessive salivation (HP:0003781)1.67549608
97Preaxial hand polydactyly (HP:0001177)1.67294843
98Anophthalmia (HP:0000528)1.67097663
99Abnormal rod and cone electroretinograms (HP:0008323)1.66830319
100Severe muscular hypotonia (HP:0006829)1.65839296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.50992826
2BMPR1B3.27864441
3ACVR1B2.91934514
4ZAK2.80224920
5ADRBK22.78460386
6WNK32.50876392
7PNCK2.37907508
8NUAK12.19307276
9CASK2.18810410
10MKNK22.04837256
11TLK11.98420384
12GRK11.95877941
13INSRR1.92501567
14MAPK131.82697866
15MAP4K21.82542904
16TNIK1.81241566
17PINK11.78241847
18MAP3K41.74736022
19MARK11.69102619
20WNK41.64839270
21TAOK31.59449194
22DAPK21.50015322
23DYRK21.42858423
24TGFBR11.32235018
25CAMK1G1.25223441
26FGFR21.24106114
27OXSR11.23748881
28MAPK151.22536309
29MKNK11.20730418
30VRK11.15600931
31ADRBK11.10286450
32BRSK21.07435710
33CAMKK21.05312346
34PAK31.02494467
35CAMK1D1.00264853
36WEE10.95760430
37NTRK30.90086093
38PRKCG0.88517915
39STK38L0.84904098
40IRAK10.84529476
41SIK20.83724588
42STK390.82338680
43PLK40.80838254
44TRIM280.77536984
45NTRK20.75935411
46NEK20.74643605
47BRD40.73577064
48NLK0.73020955
49CHEK20.71954600
50STK110.71699990
51PRKCE0.71565549
52STK30.71226568
53PLK30.69955882
54MAP2K70.69343072
55CAMK10.67115273
56EPHA40.66123277
57CSNK1G20.65277056
58NME10.63485229
59CSNK1G10.62120695
60MAP2K60.61682220
61ATR0.60846320
62LATS10.60261525
63TAF10.60203930
64PIK3CA0.59335142
65AKT30.58222834
66DYRK1A0.57280520
67SGK20.57028088
68CDC70.56769908
69RPS6KA50.56769323
70MUSK0.56725538
71TXK0.56225309
72PKN10.55144355
73TIE10.54433561
74MAPKAPK50.54230123
75PRKAA10.52942526
76EPHA30.52335119
77PLK20.50630062
78CDK30.49470541
79TYRO30.47499580
80WNK10.47433841
81MAP2K40.47388673
82PLK10.47245539
83PASK0.47021514
84TEC0.46708701
85CSNK1D0.46563362
86CSNK1A1L0.46536523
87ATM0.44461712
88BCR0.44437721
89CAMK40.43615357
90CSNK1G30.43452528
91PTK2B0.41540998
92ERBB20.40658201
93CAMK2A0.39039203
94FLT30.38033574
95PHKG20.37879967
96PHKG10.37879967
97SGK2230.37797263
98SGK4940.37797263
99CSNK1A10.37705026
100SRPK10.37384577

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.95704424
2Selenocompound metabolism_Homo sapiens_hsa004502.72538014
3Nicotine addiction_Homo sapiens_hsa050332.68132136
4Nitrogen metabolism_Homo sapiens_hsa009102.37296724
5Linoleic acid metabolism_Homo sapiens_hsa005912.27983775
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21803052
7Homologous recombination_Homo sapiens_hsa034402.21555357
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18293698
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15605785
10RNA polymerase_Homo sapiens_hsa030202.14126264
11Fanconi anemia pathway_Homo sapiens_hsa034602.13789225
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09314251
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.01223940
14Butanoate metabolism_Homo sapiens_hsa006502.00525656
15Basal transcription factors_Homo sapiens_hsa030221.89570906
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81916309
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78112454
18Taste transduction_Homo sapiens_hsa047421.77837572
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77310989
20Ether lipid metabolism_Homo sapiens_hsa005651.73687893
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71614266
22Morphine addiction_Homo sapiens_hsa050321.60214990
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58124089
24RNA degradation_Homo sapiens_hsa030181.50857035
25Tryptophan metabolism_Homo sapiens_hsa003801.48395678
26Olfactory transduction_Homo sapiens_hsa047401.47200236
27Oxidative phosphorylation_Homo sapiens_hsa001901.42319396
28Protein export_Homo sapiens_hsa030601.41168135
29Glutamatergic synapse_Homo sapiens_hsa047241.32118633
30Circadian entrainment_Homo sapiens_hsa047131.31337546
31One carbon pool by folate_Homo sapiens_hsa006701.25199537
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21830046
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20384373
34Insulin secretion_Homo sapiens_hsa049111.19702682
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19498079
36Parkinsons disease_Homo sapiens_hsa050121.16807541
37Serotonergic synapse_Homo sapiens_hsa047261.15502101
38GABAergic synapse_Homo sapiens_hsa047271.12760495
39ABC transporters_Homo sapiens_hsa020101.11610851
40Non-homologous end-joining_Homo sapiens_hsa034501.08694071
41Propanoate metabolism_Homo sapiens_hsa006401.08536046
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07390787
43Basal cell carcinoma_Homo sapiens_hsa052171.04058187
44Caffeine metabolism_Homo sapiens_hsa002321.02341937
45Cardiac muscle contraction_Homo sapiens_hsa042601.02134824
46Huntingtons disease_Homo sapiens_hsa050161.01484253
47Lysine degradation_Homo sapiens_hsa003101.00375221
48Hedgehog signaling pathway_Homo sapiens_hsa043400.95308528
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93017648
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87981047
51Dorso-ventral axis formation_Homo sapiens_hsa043200.87033178
52Ovarian steroidogenesis_Homo sapiens_hsa049130.86267114
53Circadian rhythm_Homo sapiens_hsa047100.86227721
54Long-term depression_Homo sapiens_hsa047300.84911528
55Dopaminergic synapse_Homo sapiens_hsa047280.84185612
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.83536141
57Calcium signaling pathway_Homo sapiens_hsa040200.82956940
58Cocaine addiction_Homo sapiens_hsa050300.81557969
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.81091305
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78297100
61Regulation of autophagy_Homo sapiens_hsa041400.76882401
62Cholinergic synapse_Homo sapiens_hsa047250.75246960
63Purine metabolism_Homo sapiens_hsa002300.70058239
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69175854
65RNA transport_Homo sapiens_hsa030130.68411637
66Alzheimers disease_Homo sapiens_hsa050100.67174565
67Glycerolipid metabolism_Homo sapiens_hsa005610.63734619
68Salivary secretion_Homo sapiens_hsa049700.61484598
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61363593
70Hippo signaling pathway_Homo sapiens_hsa043900.60289066
71Nucleotide excision repair_Homo sapiens_hsa034200.59458873
72Peroxisome_Homo sapiens_hsa041460.58421795
73Chemical carcinogenesis_Homo sapiens_hsa052040.58282262
74Amphetamine addiction_Homo sapiens_hsa050310.57479965
75Retinol metabolism_Homo sapiens_hsa008300.57195559
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56727409
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56525408
78cAMP signaling pathway_Homo sapiens_hsa040240.56469603
79Arachidonic acid metabolism_Homo sapiens_hsa005900.56183017
80Oxytocin signaling pathway_Homo sapiens_hsa049210.54311110
81TGF-beta signaling pathway_Homo sapiens_hsa043500.52712876
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.52334693
83Alcoholism_Homo sapiens_hsa050340.51666781
84Axon guidance_Homo sapiens_hsa043600.50818495
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.50444081
86Histidine metabolism_Homo sapiens_hsa003400.45289649
87Pyrimidine metabolism_Homo sapiens_hsa002400.44399557
88beta-Alanine metabolism_Homo sapiens_hsa004100.43911223
89Gastric acid secretion_Homo sapiens_hsa049710.42435213
90Steroid biosynthesis_Homo sapiens_hsa001000.42393483
91Type II diabetes mellitus_Homo sapiens_hsa049300.39285779
92Ribosome_Homo sapiens_hsa030100.38678267
93Metabolic pathways_Homo sapiens_hsa011000.38112182
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38051865
95Systemic lupus erythematosus_Homo sapiens_hsa053220.38019709
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37416721
97Wnt signaling pathway_Homo sapiens_hsa043100.35139330
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34217107
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.32843334
100Base excision repair_Homo sapiens_hsa034100.31692278

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