ZNF791

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.51365447
2fucose catabolic process (GO:0019317)4.19313242
3L-fucose metabolic process (GO:0042354)4.19313242
4L-fucose catabolic process (GO:0042355)4.19313242
5neural tube formation (GO:0001841)3.77895497
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61359131
7nonmotile primary cilium assembly (GO:0035058)3.54949946
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.44369255
9regulation of translation, ncRNA-mediated (GO:0045974)3.44369255
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44369255
11cellular ketone body metabolic process (GO:0046950)3.39403753
12indole-containing compound catabolic process (GO:0042436)3.35159432
13indolalkylamine catabolic process (GO:0046218)3.35159432
14tryptophan catabolic process (GO:0006569)3.35159432
15kidney morphogenesis (GO:0060993)3.34173288
16kynurenine metabolic process (GO:0070189)3.26648959
17detection of light stimulus involved in visual perception (GO:0050908)3.25556069
18detection of light stimulus involved in sensory perception (GO:0050962)3.25556069
19cornea development in camera-type eye (GO:0061303)3.24498305
20response to pheromone (GO:0019236)3.20947642
21gamma-aminobutyric acid transport (GO:0015812)3.20873403
22indolalkylamine metabolic process (GO:0006586)3.19404359
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14651169
24pyrimidine nucleobase catabolic process (GO:0006208)3.12860617
25negative regulation of mast cell activation (GO:0033004)3.11965621
26negative regulation of telomere maintenance (GO:0032205)3.11443641
27ketone body metabolic process (GO:1902224)3.08125548
28head development (GO:0060322)3.01383012
29protein K11-linked deubiquitination (GO:0035871)2.98956911
30somite development (GO:0061053)2.98444864
31protein polyglutamylation (GO:0018095)2.96824287
32neuronal action potential (GO:0019228)2.94292786
33protein localization to cilium (GO:0061512)2.92242639
34DNA deamination (GO:0045006)2.91119972
35preassembly of GPI anchor in ER membrane (GO:0016254)2.90439342
36behavioral response to ethanol (GO:0048149)2.90154924
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87303520
38mitochondrial respiratory chain complex I assembly (GO:0032981)2.87303520
39NADH dehydrogenase complex assembly (GO:0010257)2.87303520
40epithelial cilium movement (GO:0003351)2.86396455
41presynaptic membrane assembly (GO:0097105)2.85871362
42regulation of telomere maintenance (GO:0032204)2.83859389
43tryptophan metabolic process (GO:0006568)2.83776503
44ubiquinone biosynthetic process (GO:0006744)2.83325884
45regulation of glucokinase activity (GO:0033131)2.81036221
46regulation of hexokinase activity (GO:1903299)2.81036221
47cilium morphogenesis (GO:0060271)2.80727426
48axoneme assembly (GO:0035082)2.80155692
49sulfation (GO:0051923)2.79616298
50endoderm formation (GO:0001706)2.77896882
51cilium organization (GO:0044782)2.76539353
52protein complex biogenesis (GO:0070271)2.76442765
53rRNA catabolic process (GO:0016075)2.76137289
54ubiquinone metabolic process (GO:0006743)2.75595731
55platelet dense granule organization (GO:0060155)2.73638992
56positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.71760403
57cilium assembly (GO:0042384)2.70470214
58primary amino compound metabolic process (GO:1901160)2.70110443
59regulation of action potential (GO:0098900)2.69335680
60indole-containing compound metabolic process (GO:0042430)2.65743634
61respiratory chain complex IV assembly (GO:0008535)2.65374590
62photoreceptor cell maintenance (GO:0045494)2.64031554
63nucleobase catabolic process (GO:0046113)2.62274646
64spinal cord motor neuron differentiation (GO:0021522)2.60878470
65serotonin metabolic process (GO:0042428)2.60660550
66negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60227784
67synaptic transmission, cholinergic (GO:0007271)2.59688350
68prenylation (GO:0097354)2.57019949
69protein prenylation (GO:0018342)2.57019949
70cAMP catabolic process (GO:0006198)2.56857562
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56028212
72DNA double-strand break processing (GO:0000729)2.55405697
73mitochondrial respiratory chain complex assembly (GO:0033108)2.55116312
74presynaptic membrane organization (GO:0097090)2.54537095
75cellular biogenic amine catabolic process (GO:0042402)2.53121783
76amine catabolic process (GO:0009310)2.53121783
77establishment of protein localization to Golgi (GO:0072600)2.52897473
78reflex (GO:0060004)2.51283979
79somite rostral/caudal axis specification (GO:0032525)2.50900708
80protein-cofactor linkage (GO:0018065)2.50710651
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49685261
82cell differentiation in spinal cord (GO:0021515)2.49086598
83postsynaptic membrane organization (GO:0001941)2.48991369
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.48187901
85negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47951380
86replication fork processing (GO:0031297)2.47142382
87water-soluble vitamin biosynthetic process (GO:0042364)2.46397844
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45364154
89photoreceptor cell development (GO:0042461)2.44226577
90retina layer formation (GO:0010842)2.43446792
91regulation of mesoderm development (GO:2000380)2.43416756
92neuron cell-cell adhesion (GO:0007158)2.43361984
93mannosylation (GO:0097502)2.42214787
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41767734
95forebrain neuron differentiation (GO:0021879)2.41495023
96positive regulation of sodium ion transmembrane transport (GO:1902307)2.41214053
97retinal ganglion cell axon guidance (GO:0031290)2.40102890
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.39315333
99fucosylation (GO:0036065)2.39255927
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38753452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.17144734
2VDR_22108803_ChIP-Seq_LS180_Human3.23455756
3GBX2_23144817_ChIP-Seq_PC3_Human3.01288632
4EZH2_22144423_ChIP-Seq_EOC_Human2.92381685
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.81956587
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68809046
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68132742
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62444401
9IGF1R_20145208_ChIP-Seq_DFB_Human2.34020399
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30772396
11TAF15_26573619_Chip-Seq_HEK293_Human2.29298817
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.28718249
13EWS_26573619_Chip-Seq_HEK293_Human2.26140469
14FUS_26573619_Chip-Seq_HEK293_Human2.22203196
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16187628
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16026251
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.03131955
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02320379
19P300_19829295_ChIP-Seq_ESCs_Human2.00402104
20ER_23166858_ChIP-Seq_MCF-7_Human1.86868904
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.78899933
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72167749
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71784358
24IRF1_19129219_ChIP-ChIP_H3396_Human1.68089436
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65858665
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.64514049
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.63914045
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63787703
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62217684
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60140520
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60076643
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59906219
33AR_25329375_ChIP-Seq_VCAP_Human1.58604337
34STAT3_23295773_ChIP-Seq_U87_Human1.55629941
35SMAD4_21799915_ChIP-Seq_A2780_Human1.55343611
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55107240
37REST_21632747_ChIP-Seq_MESCs_Mouse1.53827017
38BCAT_22108803_ChIP-Seq_LS180_Human1.53168199
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53066501
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52134907
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52134907
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48863160
43AR_21572438_ChIP-Seq_LNCaP_Human1.48542032
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48276215
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46581388
46TP53_22573176_ChIP-Seq_HFKS_Human1.45280382
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.41678190
48RNF2_27304074_Chip-Seq_NSC_Mouse1.41240585
49TCF4_23295773_ChIP-Seq_U87_Human1.39117988
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37685319
51CBP_20019798_ChIP-Seq_JUKART_Human1.37335932
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37335932
53* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36656549
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36594848
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.35269880
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32582443
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31158213
58MYC_18940864_ChIP-ChIP_HL60_Human1.30608311
59RUNX2_22187159_ChIP-Seq_PCA_Human1.29213985
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27128271
61TCF4_22108803_ChIP-Seq_LS180_Human1.25440433
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25185802
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23581042
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23467183
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.22978217
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.22702297
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21906037
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20819412
69SOX2_19829295_ChIP-Seq_ESCs_Human1.19649495
70NANOG_19829295_ChIP-Seq_ESCs_Human1.19649495
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19528627
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.19130537
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18154917
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.13637137
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.12658252
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12658252
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.12041435
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.12038534
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11799818
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09564596
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09340391
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07987788
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.06197945
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06109654
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.05354365
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05221027
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.04514042
88NCOR_22424771_ChIP-Seq_293T_Human1.03474288
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.02651619
90ELK1_19687146_ChIP-ChIP_HELA_Human1.02182544
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00882948
92P53_22387025_ChIP-Seq_ESCs_Mouse1.00833230
93HOXB7_26014856_ChIP-Seq_BT474_Human0.98969389
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98961757
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98604061
96* VDR_23849224_ChIP-Seq_CD4+_Human0.97434401
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97309813
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.96460024
99EED_16625203_ChIP-ChIP_MESCs_Mouse0.96328154
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.96027356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.89028223
2MP0008877_abnormal_DNA_methylation2.83015391
3MP0002102_abnormal_ear_morphology2.70613011
4MP0003787_abnormal_imprinting2.70194075
5MP0003880_abnormal_central_pattern2.62349418
6MP0003195_calcinosis2.50449034
7MP0000569_abnormal_digit_pigmentation2.42874753
8MP0005551_abnormal_eye_electrophysiolog2.34280830
9MP0001968_abnormal_touch/_nociception2.27457941
10MP0009046_muscle_twitch2.14385097
11MP0001986_abnormal_taste_sensitivity2.12118077
12MP0003890_abnormal_embryonic-extraembry2.04940508
13MP0003136_yellow_coat_color1.99112189
14MP0006072_abnormal_retinal_apoptosis1.98368227
15MP0006276_abnormal_autonomic_nervous1.94231525
16MP0004142_abnormal_muscle_tone1.92513054
17MP0003646_muscle_fatigue1.91154867
18MP0002837_dystrophic_cardiac_calcinosis1.90475203
19MP0009745_abnormal_behavioral_response1.90396624
20MP0004043_abnormal_pH_regulation1.87541661
21MP0002736_abnormal_nociception_after1.81628672
22MP0002272_abnormal_nervous_system1.79382677
23MP0005253_abnormal_eye_physiology1.75191632
24MP0004885_abnormal_endolymph1.74915025
25MP0001485_abnormal_pinna_reflex1.73328419
26MP0002638_abnormal_pupillary_reflex1.72687862
27MP0004133_heterotaxia1.72397420
28MP0005645_abnormal_hypothalamus_physiol1.65450677
29MP0008872_abnormal_physiological_respon1.64082057
30MP0000427_abnormal_hair_cycle1.62205106
31MP0000631_abnormal_neuroendocrine_gland1.55952231
32MP0004742_abnormal_vestibular_system1.52508682
33MP0004147_increased_porphyrin_level1.49921935
34MP0008875_abnormal_xenobiotic_pharmacok1.49564077
35MP0001486_abnormal_startle_reflex1.49153901
36MP0000778_abnormal_nervous_system1.47703253
37MP0002653_abnormal_ependyma_morphology1.46780737
38MP0002735_abnormal_chemical_nociception1.45351815
39MP0002572_abnormal_emotion/affect_behav1.43456304
40MP0001984_abnormal_olfaction1.43227811
41MP0003121_genomic_imprinting1.41278637
42MP0001501_abnormal_sleep_pattern1.40429994
43MP0005174_abnormal_tail_pigmentation1.38958096
44MP0002557_abnormal_social/conspecific_i1.38211834
45MP0008995_early_reproductive_senescence1.35802893
46MP0002876_abnormal_thyroid_physiology1.34936027
47MP0005423_abnormal_somatic_nervous1.32895764
48MP0001529_abnormal_vocalization1.32613546
49MP0003011_delayed_dark_adaptation1.31474576
50MP0001188_hyperpigmentation1.29595691
51MP0002064_seizures1.26691904
52MP0005646_abnormal_pituitary_gland1.26446655
53MP0002067_abnormal_sensory_capabilities1.24691449
54MP0000372_irregular_coat_pigmentation1.24497617
55MP0003635_abnormal_synaptic_transmissio1.23642372
56MP0005386_behavior/neurological_phenoty1.23231446
57MP0004924_abnormal_behavior1.23231446
58MP0002938_white_spotting1.23032618
59MP0003122_maternal_imprinting1.19375425
60MP0001970_abnormal_pain_threshold1.17391537
61MP0002063_abnormal_learning/memory/cond1.17115061
62MP0004145_abnormal_muscle_electrophysio1.16075406
63MP0002734_abnormal_mechanical_nocicepti1.16025389
64MP0001502_abnormal_circadian_rhythm1.13241622
65MP0008789_abnormal_olfactory_epithelium1.11825668
66MP0002928_abnormal_bile_duct1.09590167
67MP0002184_abnormal_innervation1.09409161
68MP0004215_abnormal_myocardial_fiber1.09035498
69MP0002733_abnormal_thermal_nociception1.07537663
70MP0002234_abnormal_pharynx_morphology1.06020729
71MP0005084_abnormal_gallbladder_morpholo1.05460830
72MP0002751_abnormal_autonomic_nervous1.05203976
73MP0005195_abnormal_posterior_eye1.03525817
74MP0003718_maternal_effect1.03375814
75MP0003119_abnormal_digestive_system1.01550099
76MP0000383_abnormal_hair_follicle0.99221333
77MP0002752_abnormal_somatic_nervous0.98924513
78MP0003137_abnormal_impulse_conducting0.98866082
79MP0000026_abnormal_inner_ear0.95112823
80MP0000955_abnormal_spinal_cord0.94292642
81MP0005499_abnormal_olfactory_system0.94079095
82MP0005394_taste/olfaction_phenotype0.94079095
83MP0002095_abnormal_skin_pigmentation0.91386517
84MP0008775_abnormal_heart_ventricle0.90359984
85MP0001293_anophthalmia0.90190098
86MP0000647_abnormal_sebaceous_gland0.89846036
87MP0002160_abnormal_reproductive_system0.88633866
88MP0005389_reproductive_system_phenotype0.87705470
89MP0000049_abnormal_middle_ear0.87485400
90MP0001324_abnormal_eye_pigmentation0.85114913
91MP0008961_abnormal_basal_metabolism0.84906353
92MP0002822_catalepsy0.82319064
93MP0002882_abnormal_neuron_morphology0.82023227
94MP0004085_abnormal_heartbeat0.81942539
95MP0008058_abnormal_DNA_repair0.80561455
96MP0005448_abnormal_energy_balance0.78037635
97MP0001963_abnormal_hearing_physiology0.77644858
98MP0001919_abnormal_reproductive_system0.77102311
99MP0000538_abnormal_urinary_bladder0.77014804
100MP0002229_neurodegeneration0.76918798

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.32540815
2Abnormality of midbrain morphology (HP:0002418)4.00879067
3Molar tooth sign on MRI (HP:0002419)4.00879067
4Pancreatic fibrosis (HP:0100732)3.82559417
5Congenital stationary night blindness (HP:0007642)3.80939967
6Hyperventilation (HP:0002883)3.69811587
7True hermaphroditism (HP:0010459)3.69035050
8Nephronophthisis (HP:0000090)3.51352910
9Type II lissencephaly (HP:0007260)3.23898216
10Medial flaring of the eyebrow (HP:0010747)3.23307289
11Abnormality of the renal cortex (HP:0011035)3.08256178
12Abnormality of the renal medulla (HP:0100957)3.07502492
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.04279358
14Abnormality of alanine metabolism (HP:0010916)3.04279358
15Hyperalaninemia (HP:0003348)3.04279358
16Chronic hepatic failure (HP:0100626)2.82469993
17Attenuation of retinal blood vessels (HP:0007843)2.79290214
18Lissencephaly (HP:0001339)2.77312923
19Gait imbalance (HP:0002141)2.75073424
20Protruding tongue (HP:0010808)2.73717804
21Inability to walk (HP:0002540)2.69632898
22Congenital primary aphakia (HP:0007707)2.63334584
23Birth length less than 3rd percentile (HP:0003561)2.60044109
24Polydipsia (HP:0001959)2.58583615
25Abnormal drinking behavior (HP:0030082)2.58583615
26Nephrogenic diabetes insipidus (HP:0009806)2.57027123
27Cystic liver disease (HP:0006706)2.54982693
28Progressive inability to walk (HP:0002505)2.53831291
29Broad-based gait (HP:0002136)2.52263857
30Tubular atrophy (HP:0000092)2.51196564
31Absent speech (HP:0001344)2.49103406
32Large for gestational age (HP:0001520)2.47518178
33Cerebellar dysplasia (HP:0007033)2.47205021
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.45523625
35Patellar aplasia (HP:0006443)2.42765098
36Gaze-evoked nystagmus (HP:0000640)2.37355318
37Progressive cerebellar ataxia (HP:0002073)2.37351616
38Abolished electroretinogram (ERG) (HP:0000550)2.35686078
39Aplasia/Hypoplasia of the patella (HP:0006498)2.28235142
40Pendular nystagmus (HP:0012043)2.26403294
41Genetic anticipation (HP:0003743)2.25133567
42Renal cortical cysts (HP:0000803)2.24223072
43Abnormality of the pons (HP:0007361)2.24069700
44Decreased circulating renin level (HP:0003351)2.19250121
45Hypoplasia of the pons (HP:0012110)2.18445893
46Optic nerve hypoplasia (HP:0000609)2.17343126
47Genital tract atresia (HP:0001827)2.16412645
48Vaginal atresia (HP:0000148)2.14276290
49Furrowed tongue (HP:0000221)2.12235917
50Congenital hepatic fibrosis (HP:0002612)2.12168175
51Sclerocornea (HP:0000647)2.11476528
52Bile duct proliferation (HP:0001408)2.06758529
53Abnormal biliary tract physiology (HP:0012439)2.06758529
54Stomach cancer (HP:0012126)2.06685850
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06259170
56Poor coordination (HP:0002370)2.03232524
57Anencephaly (HP:0002323)2.03183459
58Pachygyria (HP:0001302)2.02542526
59Male pseudohermaphroditism (HP:0000037)2.01739803
60Methylmalonic acidemia (HP:0002912)2.01123028
61Chorioretinal atrophy (HP:0000533)2.00731348
62Polyuria (HP:0000103)1.99872639
63Fair hair (HP:0002286)1.97345680
64Congenital, generalized hypertrichosis (HP:0004540)1.96506332
65Decreased central vision (HP:0007663)1.95180543
66Aplasia/Hypoplasia of the tongue (HP:0010295)1.95057786
67Abnormality of the labia minora (HP:0012880)1.93315731
68Drooling (HP:0002307)1.92602749
69Severe muscular hypotonia (HP:0006829)1.90220511
70Febrile seizures (HP:0002373)1.89712718
71Hemiparesis (HP:0001269)1.88084468
72Widely spaced teeth (HP:0000687)1.84485201
73Keratoconus (HP:0000563)1.84432185
74Increased corneal curvature (HP:0100692)1.84432185
75Retinal dysplasia (HP:0007973)1.81978463
76Bony spicule pigmentary retinopathy (HP:0007737)1.81559806
77Postaxial foot polydactyly (HP:0001830)1.81283840
78Abnormal rod and cone electroretinograms (HP:0008323)1.81253188
79Congenital sensorineural hearing impairment (HP:0008527)1.80452321
80Colon cancer (HP:0003003)1.79962768
81Dandy-Walker malformation (HP:0001305)1.79962182
82Dynein arm defect of respiratory motile cilia (HP:0012255)1.79685368
83Absent/shortened dynein arms (HP:0200106)1.79685368
84Postaxial hand polydactyly (HP:0001162)1.77584451
85Dyskinesia (HP:0100660)1.77392298
86Short tibia (HP:0005736)1.76727147
87Hypothermia (HP:0002045)1.76267234
88Abnormal pancreas size (HP:0012094)1.74539040
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.74217524
90Small hand (HP:0200055)1.73648076
91Clumsiness (HP:0002312)1.73175204
92Limb dystonia (HP:0002451)1.72986276
93Focal motor seizures (HP:0011153)1.72457339
94Excessive salivation (HP:0003781)1.71568459
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71159109
96Concave nail (HP:0001598)1.68886626
97Focal seizures (HP:0007359)1.68291504
98Increased CSF lactate (HP:0002490)1.66102694
99Intestinal atresia (HP:0011100)1.64022351
100Narrow forehead (HP:0000341)1.63342459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.44261573
2BMPR1B3.43227355
3WNK33.26735747
4CASK2.91276471
5ADRBK22.90550185
6ACVR1B2.71756275
7ZAK2.37884402
8MAPK132.21275445
9MAP3K42.19728356
10GRK12.19515400
11PINK12.05607226
12INSRR2.02458804
13WNK42.02426077
14NUAK11.99237728
15TLK11.94264754
16MAP4K21.88915700
17PNCK1.78330389
18MAP2K71.77720535
19MKNK21.75032933
20MARK11.69327748
21TAOK31.63324049
22OXSR11.56727466
23DAPK21.52624981
24TRIM281.42878470
25BRSK21.42245098
26SIK21.29224119
27TNIK1.27116654
28ADRBK11.22589100
29STK391.21384488
30CAMKK21.17220441
31PAK31.16448526
32TGFBR11.12331610
33TXK1.02861242
34ERBB31.01727355
35BCR0.99220244
36MAPK150.96972646
37WEE10.95661667
38DYRK20.92446551
39PRKCG0.90082393
40PRKCE0.87308146
41PIK3CA0.86249320
42AKT30.85020957
43MUSK0.82796772
44CSNK1G20.80063661
45MKNK10.79089393
46EPHA40.76359625
47NTRK20.75667765
48STK38L0.72190705
49MAP2K40.69027689
50PLK20.68212738
51STK110.66637202
52EPHA30.66190140
53PKN10.66119916
54FGFR20.65779760
55CSNK1G10.63771337
56RPS6KA50.63602924
57CHUK0.59562530
58VRK10.57344461
59IRAK10.57279147
60BRD40.57174339
61NTRK30.56295186
62CSNK1A1L0.55945148
63TIE10.54073691
64CSNK1G30.52785521
65CAMK2A0.51356608
66SGK20.50137962
67TEC0.49483803
68OBSCN0.48438177
69EIF2AK30.47758227
70IKBKB0.46559698
71NEK20.46210720
72BCKDK0.46087659
73PRKACA0.46017115
74DYRK1A0.45633041
75PHKG10.45217629
76PHKG20.45217629
77PRKAA10.44699176
78PRKCQ0.43480216
79MAP2K60.41434988
80PTK2B0.40311511
81PLK30.39817245
82GRK70.38815197
83ERBB20.37451158
84SGK4940.36268662
85SGK2230.36268662
86PRKCZ0.36165273
87CAMK40.35903642
88FER0.35812689
89CSNK1D0.35188370
90PLK40.34812220
91CAMK10.34801505
92CSNK1A10.34292542
93MAPKAPK50.33666012
94CDK30.32549753
95PRKAA20.31887333
96NLK0.29595173
97FLT30.29341882
98PRKG10.29149313
99CCNB10.28428320
100MINK10.27934617

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.84694253
2Nicotine addiction_Homo sapiens_hsa050332.69003219
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.60723375
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55646233
5Butanoate metabolism_Homo sapiens_hsa006502.50613663
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47419963
7Linoleic acid metabolism_Homo sapiens_hsa005912.46503245
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38912364
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.36705200
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24760614
11Nitrogen metabolism_Homo sapiens_hsa009102.19542378
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11546985
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.08902548
14Protein export_Homo sapiens_hsa030602.00658218
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.90840753
16Oxidative phosphorylation_Homo sapiens_hsa001901.87440487
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.81885119
18Basal transcription factors_Homo sapiens_hsa030221.79597513
19Ether lipid metabolism_Homo sapiens_hsa005651.79463940
20Selenocompound metabolism_Homo sapiens_hsa004501.72467117
21Fanconi anemia pathway_Homo sapiens_hsa034601.71048630
22Taste transduction_Homo sapiens_hsa047421.61327109
23Morphine addiction_Homo sapiens_hsa050321.56903149
24Olfactory transduction_Homo sapiens_hsa047401.48322813
25Tryptophan metabolism_Homo sapiens_hsa003801.47214722
26Caffeine metabolism_Homo sapiens_hsa002321.43940073
27Homologous recombination_Homo sapiens_hsa034401.42141029
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38926175
29Propanoate metabolism_Homo sapiens_hsa006401.38365565
30RNA polymerase_Homo sapiens_hsa030201.36225951
31GABAergic synapse_Homo sapiens_hsa047271.30962166
32Parkinsons disease_Homo sapiens_hsa050121.30276584
33RNA degradation_Homo sapiens_hsa030181.26067161
34Regulation of autophagy_Homo sapiens_hsa041401.25614338
35Circadian entrainment_Homo sapiens_hsa047131.25127801
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24308282
37Peroxisome_Homo sapiens_hsa041461.22095847
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21825385
39ABC transporters_Homo sapiens_hsa020101.21450944
40Glutamatergic synapse_Homo sapiens_hsa047241.14701999
41Insulin secretion_Homo sapiens_hsa049111.14371831
42Circadian rhythm_Homo sapiens_hsa047101.12357871
43Serotonergic synapse_Homo sapiens_hsa047261.06665520
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.04178644
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.02396994
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01272602
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.00647532
48Cardiac muscle contraction_Homo sapiens_hsa042600.99570822
49Ovarian steroidogenesis_Homo sapiens_hsa049130.94535039
50Collecting duct acid secretion_Homo sapiens_hsa049660.94159274
51Chemical carcinogenesis_Homo sapiens_hsa052040.92239159
52Dopaminergic synapse_Homo sapiens_hsa047280.91030853
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87911810
54Steroid biosynthesis_Homo sapiens_hsa001000.86599607
55Huntingtons disease_Homo sapiens_hsa050160.85988527
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84001313
57Alzheimers disease_Homo sapiens_hsa050100.80193844
58beta-Alanine metabolism_Homo sapiens_hsa004100.79445099
59Arachidonic acid metabolism_Homo sapiens_hsa005900.78642295
60Retinol metabolism_Homo sapiens_hsa008300.77727905
61Dorso-ventral axis formation_Homo sapiens_hsa043200.76950388
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73085038
63Calcium signaling pathway_Homo sapiens_hsa040200.72340019
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71050885
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70785245
66Cocaine addiction_Homo sapiens_hsa050300.70580125
67Glycerolipid metabolism_Homo sapiens_hsa005610.67955162
68Salivary secretion_Homo sapiens_hsa049700.63288533
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61552982
70Sulfur relay system_Homo sapiens_hsa041220.60234975
71Amphetamine addiction_Homo sapiens_hsa050310.59433940
72Long-term depression_Homo sapiens_hsa047300.55484284
73Hedgehog signaling pathway_Homo sapiens_hsa043400.55305559
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53707605
75Purine metabolism_Homo sapiens_hsa002300.52422785
76Cholinergic synapse_Homo sapiens_hsa047250.51250322
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49018018
78Mineral absorption_Homo sapiens_hsa049780.47437296
79Histidine metabolism_Homo sapiens_hsa003400.47400552
80cAMP signaling pathway_Homo sapiens_hsa040240.47124735
81Metabolic pathways_Homo sapiens_hsa011000.46477232
82Fat digestion and absorption_Homo sapiens_hsa049750.45961206
83One carbon pool by folate_Homo sapiens_hsa006700.44955335
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41289045
85Oxytocin signaling pathway_Homo sapiens_hsa049210.38942731
86Axon guidance_Homo sapiens_hsa043600.37048456
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36165375
88Gastric acid secretion_Homo sapiens_hsa049710.36008013
89Sulfur metabolism_Homo sapiens_hsa009200.35771172
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35684010
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35389209
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.35211716
93Non-homologous end-joining_Homo sapiens_hsa034500.34857211
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.33983747
95Basal cell carcinoma_Homo sapiens_hsa052170.33712703
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33489295
97Renin secretion_Homo sapiens_hsa049240.32459718
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32204167
99Asthma_Homo sapiens_hsa053100.31247925
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29783663

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