ZNF79

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell aging (GO:0090344)8.87736661
2regulation of skeletal muscle contraction (GO:0014819)8.49942452
3cellular response to ATP (GO:0071318)8.32468160
4DNA strand renaturation (GO:0000733)8.19649684
5GDP-mannose metabolic process (GO:0019673)7.87985553
6adenosine receptor signaling pathway (GO:0001973)7.38936010
7meiotic chromosome segregation (GO:0045132)7.36525449
8G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.87883310
9rRNA methylation (GO:0031167)6.61960863
10lens fiber cell differentiation (GO:0070306)6.56331940
11mitotic cell cycle arrest (GO:0071850)6.46414291
12purinergic nucleotide receptor signaling pathway (GO:0035590)6.31599371
13peptidyl-glutamic acid carboxylation (GO:0017187)6.31361630
14protein carboxylation (GO:0018214)6.31361630
15regulation of cytokine production involved in inflammatory response (GO:1900015)5.73265168
16rRNA modification (GO:0000154)5.55135833
17regulation of synapse structural plasticity (GO:0051823)5.41548365
18negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.29062276
19response to ATP (GO:0033198)4.89130084
20sphingosine metabolic process (GO:0006670)4.85250895
21transepithelial transport (GO:0070633)4.84136134
22purinergic receptor signaling pathway (GO:0035587)4.73295035
23detection of light stimulus involved in sensory perception (GO:0050962)4.64205829
24detection of light stimulus involved in visual perception (GO:0050908)4.64205829
25granulocyte differentiation (GO:0030851)4.43920965
26positive regulation of protein kinase C signaling (GO:0090037)4.43802470
27purine ribonucleotide transport (GO:0015868)4.30477027
28G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.29320329
29diol metabolic process (GO:0034311)4.27332835
30nucleotide-sugar biosynthetic process (GO:0009226)4.25683760
31sensory perception of taste (GO:0050909)4.24102143
32positive regulation of heat generation (GO:0031652)4.22838913
33melanin biosynthetic process (GO:0042438)4.15911481
34melanin metabolic process (GO:0006582)4.13992891
35adenine nucleotide transport (GO:0051503)4.11483468
36DNA replication checkpoint (GO:0000076)4.09203099
37regulation of cell aging (GO:0090342)4.05733960
38UV protection (GO:0009650)3.96225829
39estrogen biosynthetic process (GO:0006703)3.93807262
40folic acid metabolic process (GO:0046655)3.80602613
41histone phosphorylation (GO:0016572)3.72683524
42nucleotide transmembrane transport (GO:1901679)3.71123082
43heme transport (GO:0015886)3.70231906
44regulation of phospholipid biosynthetic process (GO:0071071)3.66729869
45phosphatidylglycerol biosynthetic process (GO:0006655)3.66182926
46negative regulation of interleukin-8 production (GO:0032717)3.61205435
47folic acid transport (GO:0015884)3.60173011
48sphingoid metabolic process (GO:0046519)3.52390706
49mRNA cleavage (GO:0006379)3.49901674
50mannose metabolic process (GO:0006013)3.47292739
51oligosaccharide catabolic process (GO:0009313)3.45600584
52dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.42482725
53phosphatidylethanolamine biosynthetic process (GO:0006646)3.37654362
54regulation of heat generation (GO:0031650)3.30247399
55negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.29196405
56nucleoside transmembrane transport (GO:1901642)3.25478147
57regulation of protein kinase A signaling (GO:0010738)3.24672984
58sphingomyelin metabolic process (GO:0006684)3.22542109
59gonadal mesoderm development (GO:0007506)3.17475086
60secondary metabolite biosynthetic process (GO:0044550)3.16130248
61urinary tract smooth muscle contraction (GO:0014848)3.15650692
62DNA duplex unwinding (GO:0032508)3.14457523
63cardiolipin metabolic process (GO:0032048)3.13989620
64interferon-gamma production (GO:0032609)3.11687342
65phosphatidylethanolamine metabolic process (GO:0046337)3.09659286
66regulation of interferon-beta biosynthetic process (GO:0045357)3.04743662
67DNA geometric change (GO:0032392)3.03314571
68proline biosynthetic process (GO:0006561)3.01450848
69sulfur amino acid catabolic process (GO:0000098)2.99777337
70peristalsis (GO:0030432)2.99528484
71iron coordination entity transport (GO:1901678)2.99310882
72purine nucleotide transport (GO:0015865)2.96697512
73endocytic recycling (GO:0032456)2.95849362
74DNA deamination (GO:0045006)2.94974600
75semaphorin-plexin signaling pathway (GO:0071526)2.94881780
76trivalent inorganic anion homeostasis (GO:0072506)2.85907702
77phosphate ion homeostasis (GO:0055062)2.85907702
78cilium or flagellum-dependent cell motility (GO:0001539)2.80296154
79N-terminal protein amino acid modification (GO:0031365)2.78755442
80sialylation (GO:0097503)2.78643386
81behavioral response to nicotine (GO:0035095)2.76990301
82pseudouridine synthesis (GO:0001522)2.74793169
83mitochondrial DNA metabolic process (GO:0032042)2.74170930
84cellular anion homeostasis (GO:0030002)2.73061312
85mitochondrion distribution (GO:0048311)2.72018817
86negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.71645420
87ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.69982732
88nucleoside bisphosphate biosynthetic process (GO:0033866)2.69982732
89purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.69982732
90grooming behavior (GO:0007625)2.65618632
91tRNA modification (GO:0006400)2.64639500
92regulation of meiosis (GO:0040020)2.60859861
93phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59053415
94inositol phosphate dephosphorylation (GO:0046855)2.59053415
95negative regulation of response to biotic stimulus (GO:0002832)2.58439472
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57731904
97RNA methylation (GO:0001510)2.57721825
98sex determination (GO:0007530)2.57154847
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.56861911
100pyrimidine dimer repair (GO:0006290)2.55142168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.28427995
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.40511435
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.11297156
4* XRN2_22483619_ChIP-Seq_HELA_Human2.87977447
5MAF_26560356_Chip-Seq_TH2_Human2.74089114
6DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.64451044
7* P68_20966046_ChIP-Seq_HELA_Human2.53197966
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.42576256
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.40018243
10MAF_26560356_Chip-Seq_TH1_Human2.28597573
11LXR_22292898_ChIP-Seq_THP-1_Human2.18809858
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17925057
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13861005
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13549837
15VDR_24763502_ChIP-Seq_THP-1_Human2.08084488
16E2F1_20622854_ChIP-Seq_HELA_Human2.06841759
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.06640057
18BCOR_27268052_Chip-Seq_Bcells_Human2.04707479
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.02285117
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98893824
21CIITA_25753668_ChIP-Seq_RAJI_Human1.95420882
22BCL6_27268052_Chip-Seq_Bcells_Human1.93968208
23MYC_22102868_ChIP-Seq_BL_Human1.89872992
24DCP1A_22483619_ChIP-Seq_HELA_Human1.81352384
25RARB_24833708_ChIP-Seq_LIVER_Mouse1.80392769
26MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.79769175
27PHF8_20622854_ChIP-Seq_HELA_Human1.79698206
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.79567094
29CTCF_27219007_Chip-Seq_ERYTHROID_Human1.78449806
30CTCF_21964334_Chip-Seq_Bcells_Human1.76266029
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74830559
32RACK7_27058665_Chip-Seq_MCF-7_Human1.74772573
33UTX_26944678_Chip-Seq_JUKART_Human1.72529370
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68494811
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.67690632
36RARA_24833708_ChIP-Seq_LIVER_Mouse1.66828560
37FOXP1_21924763_ChIP-Seq_HESCs_Human1.64605955
38SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59394177
39* GABP_19822575_ChIP-Seq_HepG2_Human1.59306521
40BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.58710156
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.55992631
42E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.54347508
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53521739
44CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.52118363
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49554143
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.48673233
47* TP53_22127205_ChIP-Seq_IMR90_Human1.48349074
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48094938
49E2F7_22180533_ChIP-Seq_HELA_Human1.45717410
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44698248
51* ETS1_20019798_ChIP-Seq_JURKAT_Human1.43311730
52KDM2B_26808549_Chip-Seq_DND41_Human1.40551706
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.40009800
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.39751253
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39548046
56CTCF_27219007_Chip-Seq_Bcells_Human1.38523070
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36246347
58CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35673885
59* SMC4_20622854_ChIP-Seq_HELA_Human1.35009573
60VDR_23849224_ChIP-Seq_CD4+_Human1.34253918
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33857999
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33329136
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33145884
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32540100
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31373067
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30588375
67TCF7_22412390_ChIP-Seq_EML_Mouse1.30188893
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.30177586
69FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29917220
70ATF3_27146783_Chip-Seq_COLON_Human1.28720077
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28625861
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28332823
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.27605476
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.27056696
75CTCF_20526341_ChIP-Seq_ESCs_Human1.26438944
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22848594
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20705743
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20260674
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17576829
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15946292
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15931459
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15787258
83ETS1_21867929_ChIP-Seq_TH2_Mouse1.15615231
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.15574107
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14463018
86MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13390680
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12683713
88CREB1_26743006_Chip-Seq_LNCaP_Human1.12312005
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11958926
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.11912717
91KDM5A_27292631_Chip-Seq_BREAST_Human1.11430977
92NCOR1_26117541_ChIP-Seq_K562_Human1.11413423
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11312320
94TFEB_21752829_ChIP-Seq_HELA_Human1.10350296
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08266775
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.07000889
97ERA_21632823_ChIP-Seq_H3396_Human1.05929400
98FOXP3_21729870_ChIP-Seq_TREG_Human1.05598831
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04376540
100NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03212219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.93975160
2MP0001986_abnormal_taste_sensitivity5.77572297
3MP0005174_abnormal_tail_pigmentation5.70705119
4MP0003136_yellow_coat_color5.24174106
5MP0005423_abnormal_somatic_nervous4.37045046
6MP0005083_abnormal_biliary_tract2.82674644
7MP0000015_abnormal_ear_pigmentation2.71096083
8MP0001661_extended_life_span2.67077211
9MP0005409_darkened_coat_color2.56345947
10MP0003111_abnormal_nucleus_morphology2.49898003
11MP0004381_abnormal_hair_follicle2.49779258
12MP0001188_hyperpigmentation2.47985289
13MP0005330_cardiomyopathy2.05223162
14MP0008875_abnormal_xenobiotic_pharmacok2.03332720
15MP0000751_myopathy2.01241449
16MP0002638_abnormal_pupillary_reflex1.89586921
17MP0003806_abnormal_nucleotide_metabolis1.89562424
18MP0003453_abnormal_keratinocyte_physiol1.86801393
19MP0001756_abnormal_urination1.80133222
20MP0010094_abnormal_chromosome_stability1.79401340
21MP0002160_abnormal_reproductive_system1.73516021
22MP0003077_abnormal_cell_cycle1.67244451
23MP0000750_abnormal_muscle_regeneration1.53095403
24MP0003693_abnormal_embryo_hatching1.52055419
25MP0004957_abnormal_blastocyst_morpholog1.46625092
26MP0001502_abnormal_circadian_rhythm1.43096331
27MP0005058_abnormal_lysosome_morphology1.42307888
28MP0001968_abnormal_touch/_nociception1.38379346
29MP0000538_abnormal_urinary_bladder1.32956379
30MP0005410_abnormal_fertilization1.27528687
31MP0004130_abnormal_muscle_cell1.22766732
32MP0005501_abnormal_skin_physiology1.17985076
33MP0002254_reproductive_system_inflammat1.15852619
34MP0001873_stomach_inflammation1.14391892
35MP0001919_abnormal_reproductive_system1.13267502
36MP0010307_abnormal_tumor_latency1.11676046
37MP0000747_muscle_weakness1.10991474
38MP0005076_abnormal_cell_differentiation1.06450352
39MP0001324_abnormal_eye_pigmentation1.06182315
40MP0003448_altered_tumor_morphology1.04912666
41MP0000358_abnormal_cell_content/1.02613340
42MP0005332_abnormal_amino_acid1.01117801
43MP0009840_abnormal_foam_cell0.98501669
44MP0002019_abnormal_tumor_incidence0.98249154
45MP0002736_abnormal_nociception_after0.96859452
46MP0003091_abnormal_cell_migration0.95977243
47MP0003221_abnormal_cardiomyocyte_apopto0.95745554
48MP0000013_abnormal_adipose_tissue0.95338750
49MP0003303_peritoneal_inflammation0.91645745
50MP0009384_cardiac_valve_regurgitation0.88734847
51MP0008007_abnormal_cellular_replicative0.88716293
52MP0005257_abnormal_intraocular_pressure0.87372230
53MP0005584_abnormal_enzyme/coenzyme_acti0.85212764
54MP0000470_abnormal_stomach_morphology0.84970422
55MP0003705_abnormal_hypodermis_morpholog0.83085265
56MP0005389_reproductive_system_phenotype0.81804483
57MP0003656_abnormal_erythrocyte_physiolo0.81182228
58MP0002075_abnormal_coat/hair_pigmentati0.76418250
59MP0005084_abnormal_gallbladder_morpholo0.76125637
60MP0004197_abnormal_fetal_growth/weight/0.76107413
61MP0008058_abnormal_DNA_repair0.75283321
62MP0008057_abnormal_DNA_replication0.74669009
63MP0003172_abnormal_lysosome_physiology0.74364547
64MP0000367_abnormal_coat/_hair0.73576410
65MP0002735_abnormal_chemical_nociception0.72478924
66MP0001191_abnormal_skin_condition0.69623559
67MP0006082_CNS_inflammation0.69518290
68MP0000371_diluted_coat_color0.69465268
69MP0005551_abnormal_eye_electrophysiolog0.65839767
70MP0003137_abnormal_impulse_conducting0.65513046
71MP0005367_renal/urinary_system_phenotyp0.65398536
72MP0000516_abnormal_urinary_system0.65398536
73MP0009931_abnormal_skin_appearance0.64205692
74MP0002398_abnormal_bone_marrow0.61104243
75MP0000003_abnormal_adipose_tissue0.61076792
76MP0000689_abnormal_spleen_morphology0.60028672
77MP0002722_abnormal_immune_system0.57644024
78MP0005253_abnormal_eye_physiology0.56555312
79MP0004185_abnormal_adipocyte_glucose0.55705649
80MP0002210_abnormal_sex_determination0.54405542
81MP0001186_pigmentation_phenotype0.54084096
82MP0000313_abnormal_cell_death0.53852521
83MP0002429_abnormal_blood_cell0.53732744
84MP0001958_emphysema0.53309865
85MP0009643_abnormal_urine_homeostasis0.52678493
86MP0008260_abnormal_autophagy0.50818808
87MP0003786_premature_aging0.50767362
88MP0003763_abnormal_thymus_physiology0.50294275
89MP0002933_joint_inflammation0.50248100
90MP0002080_prenatal_lethality0.50204757
91MP0005220_abnormal_exocrine_pancreas0.48707891
92MP0001697_abnormal_embryo_size0.48513968
93MP0002086_abnormal_extraembryonic_tissu0.48410940
94MP0005310_abnormal_salivary_gland0.48115447
95MP0002136_abnormal_kidney_physiology0.46462535
96MP0004019_abnormal_vitamin_homeostasis0.46031508
97MP0001929_abnormal_gametogenesis0.45950210
98MP0002095_abnormal_skin_pigmentation0.45046341
99MP0002452_abnormal_antigen_presenting0.44973168
100MP0002723_abnormal_immune_serum0.44922745

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.15572254
2Rib fusion (HP:0000902)5.85804123
3Dyschromatopsia (HP:0007641)5.75983491
4Poikiloderma (HP:0001029)5.46369033
5Rectovaginal fistula (HP:0000143)5.34537469
6Rectal fistula (HP:0100590)5.34537469
7Attenuation of retinal blood vessels (HP:0007843)5.11144484
8Vaginal fistula (HP:0004320)4.95080732
9Intestinal fistula (HP:0100819)4.95064714
10Abnormality of the intrinsic pathway (HP:0010989)4.82345514
11Facial diplegia (HP:0001349)4.78689933
12Facial hemangioma (HP:0000329)4.74205262
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.67427312
14Squamous cell carcinoma (HP:0002860)4.49845144
15Ulnar bowing (HP:0003031)4.37977043
16Thin bony cortex (HP:0002753)4.36517733
17Mesangial abnormality (HP:0001966)4.30584103
18Popliteal pterygium (HP:0009756)4.26254966
19Hemorrhage of the eye (HP:0011885)4.13563540
20Prolonged partial thromboplastin time (HP:0003645)4.04278111
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.95271413
22Choroideremia (HP:0001139)3.91819013
23Annular pancreas (HP:0001734)3.90462475
24Increased hepatocellular lipid droplets (HP:0006565)3.90132462
25Akinesia (HP:0002304)3.85212432
26Joint hemorrhage (HP:0005261)3.79844472
27Lipid accumulation in hepatocytes (HP:0006561)3.78440774
28Renal Fanconi syndrome (HP:0001994)3.67518051
29Aplasia of the musculature (HP:0100854)3.66939560
30Congenital stationary night blindness (HP:0007642)3.55982803
31Amniotic constriction ring (HP:0009775)3.51431009
32Abnormality of placental membranes (HP:0011409)3.51431009
33Anteriorly placed anus (HP:0001545)3.46449058
34Fetal akinesia sequence (HP:0001989)3.44062968
35Abnormal albumin level (HP:0012116)3.40250397
36Hypoalbuminemia (HP:0003073)3.40250397
37Bony spicule pigmentary retinopathy (HP:0007737)3.31109545
38Short chin (HP:0000331)3.22595734
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.21524486
40Decreased electroretinogram (ERG) amplitude (HP:0000654)3.18054371
41Turricephaly (HP:0000262)3.14791748
42Coronal craniosynostosis (HP:0004440)3.06650464
43Chorioretinal atrophy (HP:0000533)3.05352164
44Abnormality of the costochondral junction (HP:0000919)3.02554461
45Delayed epiphyseal ossification (HP:0002663)3.02420471
46Patellar aplasia (HP:0006443)3.00337608
47Basal cell carcinoma (HP:0002671)2.96819872
48Increased intramyocellular lipid droplets (HP:0012240)2.91105812
49Absent thumb (HP:0009777)2.87835780
50Capillary hemangiomas (HP:0005306)2.85184150
51Atrioventricular block (HP:0001678)2.80289359
52Increased muscle lipid content (HP:0009058)2.75935761
53Aplasia/Hypoplasia of the patella (HP:0006498)2.73967891
54Premature graying of hair (HP:0002216)2.69088151
55Short humerus (HP:0005792)2.64031387
56Enlarged epiphyses (HP:0010580)2.58336684
57Hypophosphatemic rickets (HP:0004912)2.56636194
58Aplasia/Hypoplasia involving the musculature (HP:0001460)2.55676241
59Widely patent fontanelles and sutures (HP:0004492)2.54131361
60Zonular cataract (HP:0010920)2.54124265
61Exertional dyspnea (HP:0002875)2.51179585
62Abnormality of the common coagulation pathway (HP:0010990)2.50331804
63Decreased central vision (HP:0007663)2.49834398
64Aplasia/hypoplasia of the humerus (HP:0006507)2.49356517
65Myotonia (HP:0002486)2.45918132
66Absent radius (HP:0003974)2.45347445
67Long clavicles (HP:0000890)2.44991998
68Neonatal respiratory distress (HP:0002643)2.39272965
69Choanal stenosis (HP:0000452)2.33867955
70Aplasia involving forearm bones (HP:0009822)2.29321278
71Absent forearm bone (HP:0003953)2.29321278
72Flat occiput (HP:0005469)2.24213034
73Birth length less than 3rd percentile (HP:0003561)2.22541245
74Respiratory difficulties (HP:0002880)2.19741428
75Abnormality of renal resorption (HP:0011038)2.19628617
76Increased number of teeth (HP:0011069)2.16465201
77Joint stiffness (HP:0001387)2.15333274
78Male infertility (HP:0003251)2.15289202
79Cystic hygroma (HP:0000476)2.13590470
80Bowed forearm bones (HP:0003956)2.12782833
81Bowing of the arm (HP:0006488)2.12782833
82Abnormal epiphyseal ossification (HP:0010656)2.09881589
83Malignant hyperthermia (HP:0002047)2.06167774
84Reduced antithrombin III activity (HP:0001976)2.05762260
85Abnormal urine phosphate concentration (HP:0012599)2.00593897
86Cholelithiasis (HP:0001081)2.00146768
87Neonatal onset (HP:0003623)1.97550274
88Hypoplasia of the pons (HP:0012110)1.97172016
89Abnormality of polysaccharide metabolism (HP:0011012)1.97064739
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97064739
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97064739
92Abnormality of the hepatic vasculature (HP:0006707)1.93601681
93Myopathic facies (HP:0002058)1.92911532
94Epiphyseal stippling (HP:0010655)1.90220876
95Short thumb (HP:0009778)1.89841304
96Diminished movement (HP:0002374)1.88473611
97Abnormality of the pons (HP:0007361)1.86792794
98Cheilitis (HP:0100825)1.85372757
99Thin ribs (HP:0000883)1.83658484
100Abnormal gallbladder morphology (HP:0012437)1.80077459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.08539373
2WNK44.41588994
3BLK3.79103962
4MUSK3.08884098
5STK162.94247275
6TESK22.46765271
7TLK12.40215043
8BMPR1B2.15829854
9ZAK2.08560421
10ACVR1B2.01958289
11TRIM281.87599936
12TXK1.78562725
13PIM21.75039091
14MAP2K31.64774479
15CDK61.56594573
16MELK1.52796979
17GRK61.44278597
18CSK1.43466460
19WNK11.30501726
20ZAP701.26859638
21BRSK21.23244990
22IRAK21.23212861
23EEF2K1.22547476
24MAPK111.17747291
25PBK1.16231131
26STK391.14222354
27CCNB11.13651045
28PDPK11.09275553
29BUB11.07512691
30MAP2K61.06065458
31ADRBK11.04620391
32TBK11.02728691
33DYRK1B1.02304738
34EIF2AK30.97270071
35CDK120.97053859
36CDK40.93061917
37MAP4K10.90880117
38SIK20.90294681
39ERN10.90212649
40IKBKB0.85411297
41RAF10.82535480
42PDK20.79234725
43CDC70.78503248
44ADRBK20.78099333
45ATR0.76634778
46PLK10.72482464
47SRPK10.69999115
48CHEK20.69830105
49PAK10.69629306
50PIM10.69061299
51PRKD20.68049048
52AURKA0.67987082
53TGFBR10.67938749
54NEK20.67460708
55MARK30.67356080
56PRKD10.65778538
57IKBKE0.65010778
58CDK150.64404357
59CDK180.62062862
60SIK30.55541871
61CDK11A0.54921995
62AKT30.53533404
63MAP3K140.51415023
64RPS6KA50.50176453
65ARAF0.48053061
66BRD40.46663218
67STK110.45748205
68RPS6KA20.45615173
69CSNK1D0.44757629
70GRK70.44110720
71TRIB30.43718845
72PRKCQ0.43563441
73MTOR0.41304547
74CDK140.41173686
75DYRK30.40459344
76RPS6KA60.40222482
77SMG10.39886948
78BMX0.39870404
79RPS6KL10.38313234
80RPS6KC10.38313234
81ERBB40.37751306
82NEK90.36605328
83PRKAA10.36312714
84MAPKAPK30.35850652
85MAPK120.34962159
86KSR20.34684816
87LYN0.34362218
88CDK80.32585701
89MAPK80.32540711
90SIK10.31659181
91EPHA20.30524232
92MAP3K30.29505512
93FRK0.27653590
94IRAK30.27466382
95STK40.26917323
96SYK0.25934121
97CHUK0.24872158
98NEK60.23028054
99CDK10.22111375
100AKT20.22097349

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.32774670
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001306.51264844
3Sulfur relay system_Homo sapiens_hsa041224.28154904
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.51536033
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.18157838
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.82162349
7Fructose and mannose metabolism_Homo sapiens_hsa000512.45681041
8Fanconi anemia pathway_Homo sapiens_hsa034602.44959487
9Sphingolipid metabolism_Homo sapiens_hsa006002.39503032
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.29244314
11Circadian rhythm_Homo sapiens_hsa047101.70538193
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63341935
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63109485
14Other glycan degradation_Homo sapiens_hsa005111.56495242
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51527291
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.36411781
17Lysosome_Homo sapiens_hsa041421.20768326
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18604362
19RNA polymerase_Homo sapiens_hsa030201.17440124
20Systemic lupus erythematosus_Homo sapiens_hsa053221.15782627
21Hedgehog signaling pathway_Homo sapiens_hsa043401.15050323
22Non-homologous end-joining_Homo sapiens_hsa034501.14552483
23Base excision repair_Homo sapiens_hsa034101.11231155
24Cell cycle_Homo sapiens_hsa041101.02668882
25Basal transcription factors_Homo sapiens_hsa030221.01664709
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99398176
27p53 signaling pathway_Homo sapiens_hsa041150.98660914
28Inositol phosphate metabolism_Homo sapiens_hsa005620.98158198
29mTOR signaling pathway_Homo sapiens_hsa041500.97636742
30Alcoholism_Homo sapiens_hsa050340.94951207
31Homologous recombination_Homo sapiens_hsa034400.91439981
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90176818
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85474398
34Hematopoietic cell lineage_Homo sapiens_hsa046400.82433300
35Vitamin digestion and absorption_Homo sapiens_hsa049770.80977371
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77779660
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77222080
38Primary immunodeficiency_Homo sapiens_hsa053400.76720978
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74936469
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.72425796
41Apoptosis_Homo sapiens_hsa042100.70690425
42Taste transduction_Homo sapiens_hsa047420.69016897
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67547094
44N-Glycan biosynthesis_Homo sapiens_hsa005100.66747773
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66096933
46Pyrimidine metabolism_Homo sapiens_hsa002400.65335580
47Bladder cancer_Homo sapiens_hsa052190.61995396
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.61685589
49Viral carcinogenesis_Homo sapiens_hsa052030.61485710
50DNA replication_Homo sapiens_hsa030300.60035027
51Herpes simplex infection_Homo sapiens_hsa051680.59347040
52Lysine degradation_Homo sapiens_hsa003100.53202170
53Measles_Homo sapiens_hsa051620.52528130
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51127145
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50730869
56Ovarian steroidogenesis_Homo sapiens_hsa049130.50375391
57Selenocompound metabolism_Homo sapiens_hsa004500.49211827
58Hippo signaling pathway_Homo sapiens_hsa043900.46147810
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45553060
60Endocytosis_Homo sapiens_hsa041440.45305911
61Influenza A_Homo sapiens_hsa051640.44968238
62Hepatitis C_Homo sapiens_hsa051600.44830731
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44716537
64TNF signaling pathway_Homo sapiens_hsa046680.42868314
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40283474
66mRNA surveillance pathway_Homo sapiens_hsa030150.40248233
67TGF-beta signaling pathway_Homo sapiens_hsa043500.39877239
68Pyruvate metabolism_Homo sapiens_hsa006200.39230060
69Hepatitis B_Homo sapiens_hsa051610.38834379
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37928869
71RNA transport_Homo sapiens_hsa030130.35744566
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.35202689
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34936827
74Nucleotide excision repair_Homo sapiens_hsa034200.34441015
75HTLV-I infection_Homo sapiens_hsa051660.33640178
76Insulin resistance_Homo sapiens_hsa049310.33407462
77FoxO signaling pathway_Homo sapiens_hsa040680.30048881
78Epstein-Barr virus infection_Homo sapiens_hsa051690.29909528
79Chronic myeloid leukemia_Homo sapiens_hsa052200.29325669
80Glutathione metabolism_Homo sapiens_hsa004800.28846278
81Osteoclast differentiation_Homo sapiens_hsa043800.28738276
82T cell receptor signaling pathway_Homo sapiens_hsa046600.28494005
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.27515368
84Dorso-ventral axis formation_Homo sapiens_hsa043200.26825905
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26693890
86Tuberculosis_Homo sapiens_hsa051520.26314791
87VEGF signaling pathway_Homo sapiens_hsa043700.23079459
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23007568
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22084835
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.21975654
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21945322
92Steroid biosynthesis_Homo sapiens_hsa001000.20947488
93ABC transporters_Homo sapiens_hsa020100.20463592
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19445840
95Mismatch repair_Homo sapiens_hsa034300.18374692
96Biosynthesis of amino acids_Homo sapiens_hsa012300.18192184
97Non-small cell lung cancer_Homo sapiens_hsa052230.14405351
98Metabolic pathways_Homo sapiens_hsa011000.14013032
99Toxoplasmosis_Homo sapiens_hsa051450.13568632
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.13436916

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