ZNF781

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serotonin receptor signaling pathway (GO:0007210)9.55882531
2negative regulation of interleukin-8 production (GO:0032717)8.84872305
3positive regulation of hair cycle (GO:0042635)8.69563396
4positive regulation of hair follicle development (GO:0051798)8.69563396
5positive regulation of osteoblast proliferation (GO:0033690)8.68845138
6angiogenesis involved in wound healing (GO:0060055)8.00912599
7regulation of appetite (GO:0032098)7.59441538
8negative regulation of circadian rhythm (GO:0042754)7.33342741
9interferon-gamma production (GO:0032609)7.31091066
10regulation of Cdc42 GTPase activity (GO:0043088)7.20104635
11negative regulation of calcium ion transport into cytosol (GO:0010523)6.97491535
12activated T cell proliferation (GO:0050798)6.80099350
13hematopoietic stem cell proliferation (GO:0071425)6.49359141
14glycoprotein catabolic process (GO:0006516)6.29049495
15protein K48-linked deubiquitination (GO:0071108)6.28619128
16protein K63-linked deubiquitination (GO:0070536)6.14894732
17lymphangiogenesis (GO:0001946)6.05009731
18regulation of hair follicle development (GO:0051797)5.71479283
19cysteine metabolic process (GO:0006534)5.59521587
20glycerophospholipid catabolic process (GO:0046475)5.56799743
21carnitine transmembrane transport (GO:1902603)5.47478308
22disruption of cells of other organism (GO:0044364)5.41902531
23killing of cells of other organism (GO:0031640)5.41902531
24sulfation (GO:0051923)5.37330633
25thyroid hormone metabolic process (GO:0042403)5.24857593
26omega-hydroxylase P450 pathway (GO:0097267)5.24749226
27granulocyte differentiation (GO:0030851)5.23694171
28mucosal immune response (GO:0002385)5.13196216
29carnitine transport (GO:0015879)5.02408380
30amino-acid betaine transport (GO:0015838)5.02408380
31paraxial mesoderm development (GO:0048339)4.88851103
32lipid translocation (GO:0034204)4.84339104
33phospholipid translocation (GO:0045332)4.84339104
34carnitine metabolic process (GO:0009437)4.80566157
35filopodium assembly (GO:0046847)4.79720464
36organ or tissue specific immune response (GO:0002251)4.72135170
37homocysteine metabolic process (GO:0050667)4.61299537
38negative regulation of metanephros development (GO:0072217)4.40758555
39defense response to fungus (GO:0050832)4.30484878
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.30483333
41organic cation transport (GO:0015695)4.21179665
42heparan sulfate proteoglycan metabolic process (GO:0030201)4.12903992
43righting reflex (GO:0060013)4.05384794
44regulation of B cell receptor signaling pathway (GO:0050855)4.04024580
45negative regulation of hormone biosynthetic process (GO:0032353)4.02734549
46flavonoid metabolic process (GO:0009812)3.99190918
47protein sumoylation (GO:0016925)3.98665373
48regulation of hair cycle (GO:0042634)3.95520787
49startle response (GO:0001964)3.95109381
50quaternary ammonium group transport (GO:0015697)3.88816929
51positive regulation of cAMP-mediated signaling (GO:0043950)3.86546999
52positive regulation of epidermis development (GO:0045684)3.81295135
53axon ensheathment in central nervous system (GO:0032291)3.77993685
54central nervous system myelination (GO:0022010)3.77993685
55negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.77255287
56maturation of 5.8S rRNA (GO:0000460)3.71638471
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.71469860
58regulation of osteoblast proliferation (GO:0033688)3.70071735
59sex differentiation (GO:0007548)3.69204900
603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.67374716
61purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.67374716
62amino-acid betaine metabolic process (GO:0006577)3.66810836
63androgen biosynthetic process (GO:0006702)3.64011269
64regulation of sarcomere organization (GO:0060297)3.62394014
65spindle assembly involved in mitosis (GO:0090307)3.62054356
66rRNA catabolic process (GO:0016075)3.59237895
67tryptophan catabolic process (GO:0006569)3.57913531
68indole-containing compound catabolic process (GO:0042436)3.57913531
69indolalkylamine catabolic process (GO:0046218)3.57913531
70negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.57685654
71regulation of steroid hormone biosynthetic process (GO:0090030)3.56176369
72cell killing (GO:0001906)3.54516584
73reflex (GO:0060004)3.51863108
74negative regulation by host of viral transcription (GO:0043922)3.50824436
75negative regulation of hormone metabolic process (GO:0032351)3.49922664
76protein-cofactor linkage (GO:0018065)3.47400660
77DNA double-strand break processing (GO:0000729)3.46627743
78skin development (GO:0043588)3.45277257
79positive regulation of vasculogenesis (GO:2001214)3.44267624
80dosage compensation (GO:0007549)3.40340120
81negative regulation of mast cell activation (GO:0033004)3.40309921
82triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35445864
83cilium or flagellum-dependent cell motility (GO:0001539)3.30410841
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27183936
85endothelial cell proliferation (GO:0001935)3.25734024
86sex determination (GO:0007530)3.22784744
87regulation of membrane lipid distribution (GO:0097035)3.22127328
88low-density lipoprotein particle remodeling (GO:0034374)3.20091267
89establishment of protein localization to Golgi (GO:0072600)3.17539421
90phosphatidylinositol acyl-chain remodeling (GO:0036149)3.15832735
91synaptic vesicle docking involved in exocytosis (GO:0016081)3.14074037
92positive regulation of oligodendrocyte differentiation (GO:0048714)3.13325317
93positive regulation of hemostasis (GO:1900048)3.12045473
94positive regulation of blood coagulation (GO:0030194)3.12045473
95nuclear pore organization (GO:0006999)3.04149055
96myoblast migration (GO:0051451)3.03780903
97neuron fate determination (GO:0048664)3.01331898
98diaphragm development (GO:0060539)3.00281105
99purine nucleoside bisphosphate metabolic process (GO:0034032)2.99033703
100protein K11-linked deubiquitination (GO:0035871)16.2610262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human6.74883329
2IKZF1_21737484_ChIP-ChIP_HCT116_Human5.30466929
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.64270143
4SMAD_19615063_ChIP-ChIP_OVARY_Human4.03970706
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.47532004
6TAF15_26573619_Chip-Seq_HEK293_Human3.30434949
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.28896883
8DROSHA_22980978_ChIP-Seq_HELA_Human2.68621835
9TP53_16413492_ChIP-PET_HCT116_Human2.58364004
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53089623
11AR_21572438_ChIP-Seq_LNCaP_Human2.51546768
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16468794
13AR_25329375_ChIP-Seq_VCAP_Human2.15110940
14IGF1R_20145208_ChIP-Seq_DFB_Human2.13211582
15ER_23166858_ChIP-Seq_MCF-7_Human1.97076097
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86109839
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.84868550
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81487657
19EZH2_22144423_ChIP-Seq_EOC_Human1.77434454
20LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70615486
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67688560
22SMAD4_21799915_ChIP-Seq_A2780_Human1.66556160
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62691555
24OCT4_21477851_ChIP-Seq_ESCs_Mouse1.61814950
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59100736
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58752527
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.58435969
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57958314
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55225441
30FOXA1_21572438_ChIP-Seq_LNCaP_Human1.52068150
31FLI1_21867929_ChIP-Seq_TH2_Mouse1.51768378
32STAT3_23295773_ChIP-Seq_U87_Human1.50652302
33EWS_26573619_Chip-Seq_HEK293_Human1.48557426
34TP53_22573176_ChIP-Seq_HFKS_Human1.45012509
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44464765
36ZNF274_21170338_ChIP-Seq_K562_Hela1.44220371
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44185127
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.44059765
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.42311462
40CRX_20693478_ChIP-Seq_RETINA_Mouse1.41850240
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38685420
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.36695256
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34813290
44LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34679724
45TP53_18474530_ChIP-ChIP_U2OS_Human1.33236923
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32535913
47TCF4_23295773_ChIP-Seq_U87_Human1.30979720
48P300_19829295_ChIP-Seq_ESCs_Human1.30847195
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27122942
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24889469
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23898875
52CBP_20019798_ChIP-Seq_JUKART_Human1.23898875
53KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23696144
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23613184
55SOX3_22085726_ChIP-Seq_MUSCLE_Mouse1.18207757
56SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17791723
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17302026
58TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16629869
59RUNX2_22187159_ChIP-Seq_PCA_Human1.16295065
60CDX2_22108803_ChIP-Seq_LS180_Human1.13277971
61JUN_21703547_ChIP-Seq_K562_Human1.12824383
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11719501
63FUS_26573619_Chip-Seq_HEK293_Human1.11371455
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10678211
65WDR5_24793694_ChIP-Seq_LNCAP_Human1.10481221
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.10440502
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08010289
68AR_19668381_ChIP-Seq_PC3_Human1.07399397
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07272103
70REST_21632747_ChIP-Seq_MESCs_Mouse1.07035566
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03094773
72PHF8_20622853_ChIP-Seq_HELA_Human1.01868867
73EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98750651
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98085120
75TBL1_22424771_ChIP-Seq_293T_Human0.96565906
76CBX2_27304074_Chip-Seq_ESCs_Mouse0.95659638
77TCF4_22108803_ChIP-Seq_LS180_Human0.95364420
78* GATA3_21878914_ChIP-Seq_MCF-7_Human0.93632208
79GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.93182521
80VDR_22108803_ChIP-Seq_LS180_Human0.92190458
81SPI1_23127762_ChIP-Seq_K562_Human0.90132037
82HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90125065
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89483507
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89121189
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88611998
86BRD4_25478319_ChIP-Seq_HGPS_Human0.87952795
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87884539
88P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87876509
89ESET_19884257_ChIP-Seq_ESCs_Mouse0.87801390
90SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86145971
91CJUN_26792858_Chip-Seq_BT549_Human0.84533463
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84429513
93ERA_21632823_ChIP-Seq_H3396_Human0.84341364
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.84044090
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84044090
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83697224
97BCAT_22108803_ChIP-Seq_LS180_Human0.82634465
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.81504114
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81242137
100STAT1_20625510_ChIP-Seq_HELA_Human0.80332430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism8.53873922
2MP0002138_abnormal_hepatobiliary_system5.13263718
3MP0005310_abnormal_salivary_gland4.77328514
4MP0005670_abnormal_white_adipose4.58148274
5MP0002139_abnormal_hepatobiliary_system4.27213598
6MP0008875_abnormal_xenobiotic_pharmacok4.26370398
7MP0003806_abnormal_nucleotide_metabolis3.97588592
8MP0002254_reproductive_system_inflammat3.86966340
9MP0001984_abnormal_olfaction3.47199367
10MP0004043_abnormal_pH_regulation2.76966225
11MP0001919_abnormal_reproductive_system2.46020427
12MP0001879_abnormal_lymphatic_vessel2.00703301
13MP0005647_abnormal_sex_gland1.96082872
14MP0000613_abnormal_salivary_gland1.95732720
15MP0005389_reproductive_system_phenotype1.95703787
16MP0005187_abnormal_penis_morphology1.87290861
17MP0001873_stomach_inflammation1.86417454
18MP0005551_abnormal_eye_electrophysiolog1.77217313
19MP0001348_abnormal_lacrimal_gland1.76098189
20MP0006276_abnormal_autonomic_nervous1.71557266
21MP0002006_tumorigenesis1.71438469
22MP0006082_CNS_inflammation1.70404305
23MP0000569_abnormal_digit_pigmentation1.68956974
24MP0009046_muscle_twitch1.68333481
25MP0002064_seizures1.64264284
26MP0002970_abnormal_white_adipose1.62893170
27MP0002928_abnormal_bile_duct1.50796956
28MP0005084_abnormal_gallbladder_morpholo1.50268409
29MP0002876_abnormal_thyroid_physiology1.46443511
30MP0000230_abnormal_systemic_arterial1.43950539
31MP0002735_abnormal_chemical_nociception1.43109300
32MP0009745_abnormal_behavioral_response1.41548395
33MP0005377_hearing/vestibular/ear_phenot1.36399575
34MP0003878_abnormal_ear_physiology1.36399575
35MP0003315_abnormal_perineum_morphology1.35977889
36MP0003724_increased_susceptibility_to1.34883767
37MP0004858_abnormal_nervous_system1.34525990
38MP0004142_abnormal_muscle_tone1.16889405
39MP0003638_abnormal_response/metabolism_1.14697771
40MP0001486_abnormal_startle_reflex1.12800750
41MP0001905_abnormal_dopamine_level1.11100914
42MP0002736_abnormal_nociception_after1.08677551
43MP0001346_abnormal_lacrimal_gland1.08583555
44MP0001764_abnormal_homeostasis1.05140489
45MP0008961_abnormal_basal_metabolism1.04722668
46MP0005167_abnormal_blood-brain_barrier1.03368637
47MP0001986_abnormal_taste_sensitivity1.01282171
48MP0002269_muscular_atrophy0.99638681
49MP0001968_abnormal_touch/_nociception0.99327110
50MP0005360_urolithiasis0.99287638
51MP0002572_abnormal_emotion/affect_behav0.95978225
52MP0000639_abnormal_adrenal_gland0.94159864
53MP0001970_abnormal_pain_threshold0.92895028
54MP0002127_abnormal_cardiovascular_syste0.92177488
55MP0008569_lethality_at_weaning0.88532902
56MP0010329_abnormal_lipoprotein_level0.87706596
57MP0003936_abnormal_reproductive_system0.87462757
58MP0002971_abnormal_brown_adipose0.87201100
59MP0000383_abnormal_hair_follicle0.84570927
60MP0003195_calcinosis0.81671700
61MP0002234_abnormal_pharynx_morphology0.79254622
62MP0003646_muscle_fatigue0.77575519
63MP0005452_abnormal_adipose_tissue0.74994045
64MP0005595_abnormal_vascular_smooth0.73081330
65MP0002272_abnormal_nervous_system0.70862720
66MP0005253_abnormal_eye_physiology0.68517059
67MP0010678_abnormal_skin_adnexa0.68111498
68MP0002734_abnormal_mechanical_nocicepti0.66756044
69MP0008874_decreased_physiological_sensi0.63733839
70MP0000631_abnormal_neuroendocrine_gland0.63384228
71MP0005332_abnormal_amino_acid0.62860013
72MP0001501_abnormal_sleep_pattern0.62623171
73MP0002277_abnormal_respiratory_mucosa0.62253964
74MP0002090_abnormal_vision0.61795485
75MP0002063_abnormal_learning/memory/cond0.59988175
76MP0000371_diluted_coat_color0.56967392
77MP0002160_abnormal_reproductive_system0.56820865
78MP0002069_abnormal_eating/drinking_beha0.55823008
79MP0001440_abnormal_grooming_behavior0.55658191
80MP0000685_abnormal_immune_system0.55101223
81MP0005174_abnormal_tail_pigmentation0.54200454
82MP0002118_abnormal_lipid_homeostasis0.53767028
83MP0002210_abnormal_sex_determination0.53403363
84MP0004085_abnormal_heartbeat0.53252092
85MP0003718_maternal_effect0.51376848
86MP0005464_abnormal_platelet_physiology0.49816114
87MP0009278_abnormal_bone_marrow0.49789164
88MP0009643_abnormal_urine_homeostasis0.49765931
89MP0003632_abnormal_nervous_system0.49409515
90MP0009642_abnormal_blood_homeostasis0.49379589
91MP0001663_abnormal_digestive_system0.49374666
92MP0002229_neurodegeneration0.47981938
93MP0004924_abnormal_behavior0.47622477
94MP0005386_behavior/neurological_phenoty0.47622477
95MP0005448_abnormal_energy_balance0.46564597
96MP0005164_abnormal_response_to0.45278293
97MP0010155_abnormal_intestine_physiology0.44877167
98MP0003635_abnormal_synaptic_transmissio0.43686959
99MP0001664_abnormal_digestion0.43271391
100MP0001270_distended_abdomen0.42607622

Predicted human phenotypes

RankGene SetZ-score
1Congenital sensorineural hearing impairment (HP:0008527)6.56014421
2Optic neuritis (HP:0100653)6.21205684
3Retrobulbar optic neuritis (HP:0100654)6.21205684
4Lower limb hyperreflexia (HP:0002395)6.16811292
5Bilateral sensorineural hearing impairment (HP:0008619)5.58381076
6Orchitis (HP:0100796)5.46717518
7Keratoconjunctivitis (HP:0001096)5.38901590
8Poikiloderma (HP:0001029)5.17063488
9Decreased circulating renin level (HP:0003351)4.71717510
10Abnormal pancreas size (HP:0012094)4.48938239
11Myositis (HP:0100614)4.35075703
12Enlarged penis (HP:0000040)4.11917579
13Keratoconjunctivitis sicca (HP:0001097)4.04345772
14Abnormality of the pericardium (HP:0001697)4.00325627
15Hypoplasia of the uterus (HP:0000013)3.87619846
16Abolished electroretinogram (ERG) (HP:0000550)3.67027078
17Gout (HP:0001997)3.66056049
18True hermaphroditism (HP:0010459)3.65220021
19Attenuation of retinal blood vessels (HP:0007843)3.63075376
20Congenital stationary night blindness (HP:0007642)3.61215089
21Unilateral renal agenesis (HP:0000122)3.42124718
22Hyperglycinuria (HP:0003108)3.35923368
23Hyperventilation (HP:0002883)3.28097596
24Bony spicule pigmentary retinopathy (HP:0007737)3.22807192
25Abnormality of dentin (HP:0010299)3.09266622
26Tinnitus (HP:0000360)3.02796076
27Late onset (HP:0003584)2.98648756
28Male pseudohermaphroditism (HP:0000037)2.98413319
29Xanthomatosis (HP:0000991)2.95800613
30Pancreatic cysts (HP:0001737)2.85123213
31Bicornuate uterus (HP:0000813)2.82186172
32Gonadotropin excess (HP:0000837)2.80495191
33Aplasia/hypoplasia of the uterus (HP:0008684)2.77841515
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69180731
35Absent speech (HP:0001344)2.67544440
36Preaxial foot polydactyly (HP:0001841)2.63426863
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.61328930
38Mesangial abnormality (HP:0001966)2.60043278
39Anorexia (HP:0002039)2.59902725
40Pancreatic fibrosis (HP:0100732)2.59674314
41Basal ganglia calcification (HP:0002135)2.52013285
42Polydipsia (HP:0001959)2.48585189
43Abnormal drinking behavior (HP:0030082)2.48585189
44Spastic paraplegia (HP:0001258)2.45894966
45Acne (HP:0001061)2.40731056
46Abnormality of dental color (HP:0011073)2.39925910
47Keratitis (HP:0000491)2.39063345
48Spastic tetraparesis (HP:0001285)2.37812584
49Chronic hepatic failure (HP:0100626)2.37122154
50Bicuspid aortic valve (HP:0001647)2.36040816
51Hyperaldosteronism (HP:0000859)2.33398750
52Anomalous pulmonary venous return (HP:0010772)2.33292755
53Breast carcinoma (HP:0003002)2.31157827
54Hemoptysis (HP:0002105)2.30057310
55Amelogenesis imperfecta (HP:0000705)2.28632244
56Craniofacial hyperostosis (HP:0004493)2.27477131
57Abnormality of the left ventricular outflow tract (HP:0011103)2.25898055
58Subaortic stenosis (HP:0001682)2.25898055
59Encephalitis (HP:0002383)2.25336458
60Clumsiness (HP:0002312)2.22671325
61Germ cell neoplasia (HP:0100728)2.21083651
62Frequent falls (HP:0002359)2.20756602
63Delayed puberty (HP:0000823)2.20654754
64Paraplegia (HP:0010550)2.20013140
65Abnormality of glycine metabolism (HP:0010895)2.17777912
66Abnormality of serine family amino acid metabolism (HP:0010894)2.17777912
67Abnormality of renin-angiotensin system (HP:0000847)2.15902224
68Pulmonary embolism (HP:0002204)2.13419434
69Vertigo (HP:0002321)2.11935804
70Bile duct proliferation (HP:0001408)2.10017938
71Abnormal biliary tract physiology (HP:0012439)2.10017938
72Atrioventricular block (HP:0001678)2.07781454
73Aplasia/Hypoplasia of the spleen (HP:0010451)2.07498729
74Retinal atrophy (HP:0001105)2.04413241
75Abnormality of the pulmonary veins (HP:0011718)2.02720132
76CNS demyelination (HP:0007305)2.01835727
77Ileus (HP:0002595)2.01170491
78Gangrene (HP:0100758)2.00964614
79Glucose intolerance (HP:0000833)2.00248435
80Opisthotonus (HP:0002179)1.99230087
81Hyperactive renin-angiotensin system (HP:0000841)1.98996895
82Arterial thrombosis (HP:0004420)1.98327793
83Abnormality of the dental pulp (HP:0006479)1.96241000
84Constricted visual fields (HP:0001133)1.95163634
85Hyperkalemia (HP:0002153)1.94545800
86Abnormal glucose tolerance (HP:0001952)1.93542623
87Tapered finger (HP:0001182)1.92948785
88Loss of speech (HP:0002371)1.92133010
89Glomerulopathy (HP:0100820)1.90452564
90Hydroxyprolinuria (HP:0003080)1.90052762
91Abnormality of proline metabolism (HP:0010907)1.90052762
92Stage 5 chronic kidney disease (HP:0003774)1.90031434
93Delayed closure of the anterior fontanelle (HP:0001476)1.86309800
94Hyperglycinemia (HP:0002154)1.75491385
95Pancreatitis (HP:0001733)1.73199810
96Cranial hyperostosis (HP:0004437)1.72599389
97Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72494343
98Pulmonary infiltrates (HP:0002113)1.71528545
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.71101419
100Ventricular fibrillation (HP:0001663)1.71074219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.68245042
2WNK37.45944157
3TXK5.09384313
4PINK14.09337150
5BLK3.20312398
6EEF2K3.13954394
7MAPKAPK32.41822524
8YES12.39783590
9ZAK2.08002838
10FER1.95578687
11CDK121.89195925
12IRAK11.63240138
13ADRBK21.42406826
14MAPKAPK51.39971920
15NTRK31.37750816
16PRKCZ1.35926877
17TRPM71.27462831
18GRK11.19799208
19EIF2AK31.16159775
20TAOK31.02292573
21CSK1.01946125
22STK391.00303262
23MAPK130.97190924
24OXSR10.95215909
25PIK3CA0.87681080
26STK38L0.79103435
27EIF2AK20.75084655
28BCKDK0.74035431
29NEK10.71503136
30PRKD30.68690004
31CHEK20.67219446
32WNK40.64708404
33CSF1R0.64199101
34ADRBK10.60640918
35GRK70.59229225
36PRKD20.58476641
37PRKCH0.56692542
38RPS6KB20.56565628
39IGF1R0.54710977
40PLK40.52990699
41MAP3K70.51186037
42PRKG10.50168021
43MAPK110.49969376
44FLT30.48538850
45STK240.48255912
46PRKCB0.45153173
47LIMK10.43323930
48TLK10.43050746
49MKNK10.41966444
50PRKCA0.41908004
51TIE10.38459877
52PDK10.36634101
53MAP2K10.36364832
54CAMK1D0.35597176
55JAK10.33359656
56BMPR1B0.33016493
57GSK3A0.32697508
58CAMK10.31781726
59CAMK2A0.30568598
60RPS6KA50.29159481
61RPS6KA40.26057869
62TTK0.25289506
63TEC0.25271727
64PRKACA0.25117785
65RPS6KA30.24290112
66RPS6KA20.23048143
67MAPK70.21419839
68LYN0.20965664
69CDK30.20875929
70CSNK1A10.20249394
71MAPK100.18936921
72INSRR0.18270242
73INSR0.18021125
74PRKAA20.17410647
75GSK3B0.17083753
76PRKCQ0.16199138
77TGFBR20.15902916
78MKNK20.15631920
79MAPK120.15183540
80KIT0.13934853
81PRKCE0.13846325
82PRKCG0.13706645
83SIK20.13057742
84DYRK20.12761500
85MAPK140.11871258
86IKBKB0.11827897
87RPS6KB10.11570273
88MAPK10.10977625
89MAP3K80.10900485
90STK380.10823583
91MAP4K20.10265008
92LMTK20.10218905
93OBSCN0.10162506
94SIK10.09946333
95PRKDC0.08760208
96NEK20.08561363
97CDK60.08469370
98MET0.07903968
99MOS0.07892588
100PLK20.07670058

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005316.78187495
2Selenocompound metabolism_Homo sapiens_hsa004503.91736899
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.22570758
4Linoleic acid metabolism_Homo sapiens_hsa005912.64117330
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61391139
6Butanoate metabolism_Homo sapiens_hsa006502.53794630
7Ether lipid metabolism_Homo sapiens_hsa005652.42373834
8Arachidonic acid metabolism_Homo sapiens_hsa005902.41884685
9Histidine metabolism_Homo sapiens_hsa003402.39121289
10Propanoate metabolism_Homo sapiens_hsa006402.33002400
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.32963059
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.21959570
13Nicotine addiction_Homo sapiens_hsa050332.02026280
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.92074757
15N-Glycan biosynthesis_Homo sapiens_hsa005101.79517431
16Serotonergic synapse_Homo sapiens_hsa047261.79026981
17Salivary secretion_Homo sapiens_hsa049701.76237174
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72009605
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.71340212
20Calcium signaling pathway_Homo sapiens_hsa040201.69976565
21Glycerolipid metabolism_Homo sapiens_hsa005611.64517622
22Fat digestion and absorption_Homo sapiens_hsa049751.61764272
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59676285
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49137338
25Phototransduction_Homo sapiens_hsa047441.48400323
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45057899
27Proteasome_Homo sapiens_hsa030501.43934064
28Tryptophan metabolism_Homo sapiens_hsa003801.42787295
29Dorso-ventral axis formation_Homo sapiens_hsa043201.39939492
30Staphylococcus aureus infection_Homo sapiens_hsa051501.37719878
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37464712
32Glutathione metabolism_Homo sapiens_hsa004801.33006630
33cAMP signaling pathway_Homo sapiens_hsa040241.19433826
34Olfactory transduction_Homo sapiens_hsa047401.15671198
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14748286
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.14061538
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.13838566
38Ovarian steroidogenesis_Homo sapiens_hsa049131.12209712
39Vitamin digestion and absorption_Homo sapiens_hsa049771.09860863
40Fatty acid metabolism_Homo sapiens_hsa012121.07850370
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04925700
42Fatty acid degradation_Homo sapiens_hsa000710.99699751
43Lysine degradation_Homo sapiens_hsa003100.96359658
44Oxytocin signaling pathway_Homo sapiens_hsa049210.95040787
45Fatty acid biosynthesis_Homo sapiens_hsa000610.94566781
46Peroxisome_Homo sapiens_hsa041460.93099688
47ABC transporters_Homo sapiens_hsa020100.92481313
48Morphine addiction_Homo sapiens_hsa050320.91144339
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86041582
50Fanconi anemia pathway_Homo sapiens_hsa034600.84813177
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.80580264
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80319526
53Cholinergic synapse_Homo sapiens_hsa047250.80265162
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.79186338
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73706746
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70281199
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70156601
58Homologous recombination_Homo sapiens_hsa034400.56429756
59Gastric acid secretion_Homo sapiens_hsa049710.55455206
60Nitrogen metabolism_Homo sapiens_hsa009100.54207306
61Metabolic pathways_Homo sapiens_hsa011000.54076112
62RNA transport_Homo sapiens_hsa030130.53619156
63Base excision repair_Homo sapiens_hsa034100.50832045
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50655976
65B cell receptor signaling pathway_Homo sapiens_hsa046620.50530800
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46819450
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.46001020
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44308562
69Non-homologous end-joining_Homo sapiens_hsa034500.42069537
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39411272
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38365594
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37546088
73Pancreatic secretion_Homo sapiens_hsa049720.36392203
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36010311
75GABAergic synapse_Homo sapiens_hsa047270.35920002
76Arginine biosynthesis_Homo sapiens_hsa002200.35445263
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35179384
78Chemical carcinogenesis_Homo sapiens_hsa052040.35173293
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33290955
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31626760
81Taste transduction_Homo sapiens_hsa047420.26112963
82Platelet activation_Homo sapiens_hsa046110.25235720
83Retinol metabolism_Homo sapiens_hsa008300.23463382
84PPAR signaling pathway_Homo sapiens_hsa033200.23199229
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.22758064
86Protein digestion and absorption_Homo sapiens_hsa049740.22407785
87Synaptic vesicle cycle_Homo sapiens_hsa047210.22344320
88Pyruvate metabolism_Homo sapiens_hsa006200.21223219
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20531383
90Adherens junction_Homo sapiens_hsa045200.19551685
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19214417
92Primary immunodeficiency_Homo sapiens_hsa053400.16909787
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15912900
94Epstein-Barr virus infection_Homo sapiens_hsa051690.15510698
95Huntingtons disease_Homo sapiens_hsa050160.13784449
96Long-term depression_Homo sapiens_hsa047300.13008216
97DNA replication_Homo sapiens_hsa030300.10896487
98Arginine and proline metabolism_Homo sapiens_hsa003300.10318126
99Sphingolipid metabolism_Homo sapiens_hsa006000.09201419
100Ras signaling pathway_Homo sapiens_hsa040140.09002402

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