ZNF777

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.80676985
2regulation of mammary gland epithelial cell proliferation (GO:0033599)4.23990355
3regulation of NFAT protein import into nucleus (GO:0051532)4.03604012
4regulation of early endosome to late endosome transport (GO:2000641)3.99437122
5protein localization to endosome (GO:0036010)3.97938988
6apoptotic process involved in morphogenesis (GO:0060561)3.79196962
7regulation of chromatin binding (GO:0035561)3.78184457
83-UTR-mediated mRNA stabilization (GO:0070935)3.77811661
9adherens junction assembly (GO:0034333)3.70211299
10modulation by symbiont of host cellular process (GO:0044068)3.60275177
11regulation of RNA export from nucleus (GO:0046831)3.52498978
12cell-substrate adherens junction assembly (GO:0007045)3.49156633
13focal adhesion assembly (GO:0048041)3.49156633
14modulation by virus of host process (GO:0019054)3.48713621
15regulation of nucleobase-containing compound transport (GO:0032239)3.45356006
16activation of Rac GTPase activity (GO:0032863)3.37552677
17intracellular estrogen receptor signaling pathway (GO:0030520)3.35719015
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34863427
19spliceosomal tri-snRNP complex assembly (GO:0000244)3.21153288
20mitotic chromosome condensation (GO:0007076)3.13737091
21activation of MAPKKK activity (GO:0000185)3.12556305
22lymph vessel development (GO:0001945)3.10961497
23RNA stabilization (GO:0043489)3.10755564
24mRNA stabilization (GO:0048255)3.10755564
25ribosomal small subunit biogenesis (GO:0042274)3.07354465
26Golgi transport vesicle coating (GO:0048200)3.03504924
27COPI coating of Golgi vesicle (GO:0048205)3.03504924
28regulation of apoptotic process involved in morphogenesis (GO:1902337)3.02569965
29heterochromatin organization (GO:0070828)3.01572426
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01467835
31regulation of glucose import in response to insulin stimulus (GO:2001273)2.99955076
32cell-substrate junction assembly (GO:0007044)2.99227100
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97913799
34negative regulation of cell size (GO:0045792)2.97772557
35mannose metabolic process (GO:0006013)2.94033273
36positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.92396107
37positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.89721039
38maternal placenta development (GO:0001893)2.84465018
39DNA unwinding involved in DNA replication (GO:0006268)2.84282919
40cytoskeletal anchoring at plasma membrane (GO:0007016)2.79729256
41embryonic process involved in female pregnancy (GO:0060136)2.79555155
42cellular response to virus (GO:0098586)2.78457352
43stress fiber assembly (GO:0043149)2.76489518
44regulation of histone H3-K27 methylation (GO:0061085)2.72807279
45negative regulation of viral release from host cell (GO:1902187)2.72761813
46glucocorticoid receptor signaling pathway (GO:0042921)2.72608896
47modulation by virus of host morphology or physiology (GO:0019048)2.70220874
48proline biosynthetic process (GO:0006561)2.69508687
49NIK/NF-kappaB signaling (GO:0038061)2.68469247
50response to laminar fluid shear stress (GO:0034616)2.67776591
51vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.64767249
52nucleosome disassembly (GO:0006337)2.64015910
53protein-DNA complex disassembly (GO:0032986)2.64015910
54positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62086184
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60447952
56response to muramyl dipeptide (GO:0032495)2.60201735
57epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57799521
58regulation of translational fidelity (GO:0006450)2.57522958
59cellular protein complex localization (GO:0034629)2.56991061
60peptidyl-arginine omega-N-methylation (GO:0035247)2.56902013
61pentose-phosphate shunt (GO:0006098)2.56082650
62intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.54685453
63regulation of response to osmotic stress (GO:0047484)2.51450428
64apoptotic process involved in development (GO:1902742)2.50704720
65basement membrane organization (GO:0071711)2.49480948
66semaphorin-plexin signaling pathway (GO:0071526)2.48829448
67negative regulation of histone methylation (GO:0031061)2.48788999
68barbed-end actin filament capping (GO:0051016)2.47864613
69positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.47588826
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.45921146
71regulation of translational termination (GO:0006449)2.43622148
72cell-cell junction maintenance (GO:0045217)2.42779470
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41893065
74protein localization to microtubule (GO:0035372)2.40849969
75embryonic eye morphogenesis (GO:0048048)2.40735865
76protein retention in ER lumen (GO:0006621)2.40734409
77negative regulation of skeletal muscle tissue development (GO:0048642)2.40668149
78atrioventricular valve morphogenesis (GO:0003181)2.40546839
79protein targeting to plasma membrane (GO:0072661)2.39162662
80negative regulation of fatty acid transport (GO:2000192)2.38811940
81positive regulation of Cdc42 GTPase activity (GO:0043089)2.37514343
82regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.36968004
83activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.36656282
84negative regulation of homotypic cell-cell adhesion (GO:0034111)2.36059316
85thymic T cell selection (GO:0045061)2.35884451
86positive regulation of histone deacetylation (GO:0031065)2.35022085
87positive regulation of myotube differentiation (GO:0010831)2.34628334
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.32842955
89skin morphogenesis (GO:0043589)2.32489279
90positive regulation of nuclease activity (GO:0032075)2.32331163
91trophectodermal cell differentiation (GO:0001829)2.31066167
92positive regulation of protein export from nucleus (GO:0046827)2.29047006
93activation of JUN kinase activity (GO:0007257)2.28111405
94positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.27175244
95corticosteroid receptor signaling pathway (GO:0031958)2.26186135
96branching involved in mammary gland duct morphogenesis (GO:0060444)2.25910067
97glucose 6-phosphate metabolic process (GO:0051156)2.25351403
98dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.25331760
99dosage compensation (GO:0007549)2.25177932
100eye morphogenesis (GO:0048592)2.24581083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.35185301
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.03126539
3VDR_21846776_ChIP-Seq_THP-1_Human3.01401597
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59708585
5LXR_22292898_ChIP-Seq_THP-1_Human2.58773430
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.56597655
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.49563504
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.47921437
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37370087
10KDM2B_26808549_Chip-Seq_DND41_Human2.25531040
11TCF7_22412390_ChIP-Seq_EML_Mouse2.21831426
12E2F7_22180533_ChIP-Seq_HELA_Human2.21440545
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21253399
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19655065
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.19109464
16RACK7_27058665_Chip-Seq_MCF-7_Human2.15520417
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06501028
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04105170
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02434509
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97400334
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97188636
22KDM2B_26808549_Chip-Seq_K562_Human1.95438320
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89773926
24ZNF263_19887448_ChIP-Seq_K562_Human1.85413683
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.73814488
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68528876
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66810611
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65167165
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64729648
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64401123
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.63425243
32VDR_24763502_ChIP-Seq_THP-1_Human1.56912059
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54280247
34MAF_26560356_Chip-Seq_TH1_Human1.51143934
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50556946
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49600644
37UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48770049
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47899840
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46981108
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.46697804
41P68_20966046_ChIP-Seq_HELA_Human1.46422396
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.45989738
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45093264
44NCOR1_26117541_ChIP-Seq_K562_Human1.43741276
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42000502
46CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41270202
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38741556
48MAF_26560356_Chip-Seq_TH2_Human1.37496302
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36818063
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36295681
51CREB1_26743006_Chip-Seq_LNCaP_Human1.35519367
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35473565
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33429906
54UTX_26944678_Chip-Seq_JUKART_Human1.31887926
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31789263
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31423397
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31357338
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.30814441
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.26983644
60ATF3_27146783_Chip-Seq_COLON_Human1.26739322
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24527052
62XRN2_22483619_ChIP-Seq_HELA_Human1.23561843
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.23500947
64CLOCK_20551151_ChIP-Seq_293T_Human1.22225613
65SMC4_20622854_ChIP-Seq_HELA_Human1.21638976
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20500378
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19995799
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19348566
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17404928
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.17140982
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.15438938
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13997553
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13175587
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12735646
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11931856
76TP53_22127205_ChIP-Seq_IMR90_Human1.11246613
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08897366
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05794172
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.04799594
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04157410
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03657406
82GATA1_19941826_ChIP-Seq_K562_Human1.01981111
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01060326
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00183391
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99456571
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98721911
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98229641
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97817832
89BCOR_27268052_Chip-Seq_Bcells_Human0.97762805
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97199626
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97139357
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96751336
93RUNX1_27514584_Chip-Seq_MCF-7_Human0.96264846
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.94688995
95CIITA_25753668_ChIP-Seq_RAJI_Human0.93523907
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93519634
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91932604
98CTCF_21964334_Chip-Seq_Bcells_Human0.91831208
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91647741
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91641756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.54233629
2MP0005451_abnormal_body_composition3.70107290
3MP0005076_abnormal_cell_differentiation3.50627862
4MP0002877_abnormal_melanocyte_morpholog2.82119088
5MP0004858_abnormal_nervous_system2.37544773
6MP0005058_abnormal_lysosome_morphology2.34816077
7MP0005623_abnormal_meninges_morphology2.34285712
8MP0004185_abnormal_adipocyte_glucose2.31650953
9MP0008260_abnormal_autophagy2.31258727
10MP0003453_abnormal_keratinocyte_physiol2.25510130
11MP0009278_abnormal_bone_marrow2.18109835
12MP0000678_abnormal_parathyroid_gland2.06081966
13MP0009840_abnormal_foam_cell2.05718761
14MP0003303_peritoneal_inflammation1.98618620
15MP0003566_abnormal_cell_adhesion1.97759616
16MP0002249_abnormal_larynx_morphology1.94859396
17MP0001849_ear_inflammation1.90667707
18MP0003091_abnormal_cell_migration1.84727801
19MP0004233_abnormal_muscle_weight1.83215908
20MP0001348_abnormal_lacrimal_gland1.80817968
21MP0008438_abnormal_cutaneous_collagen1.78120464
22MP0005409_darkened_coat_color1.77462771
23MP0000733_abnormal_muscle_development1.64820473
24MP0003300_gastrointestinal_ulcer1.64000961
25MP0001730_embryonic_growth_arrest1.62232366
26MP0010234_abnormal_vibrissa_follicle1.61384821
27MP0002089_abnormal_postnatal_growth/wei1.52616133
28MP0000537_abnormal_urethra_morphology1.52014749
29MP0002796_impaired_skin_barrier1.51834260
30MP0005501_abnormal_skin_physiology1.50535408
31MP0003111_abnormal_nucleus_morphology1.48536553
32MP0009333_abnormal_splenocyte_physiolog1.48533429
33MP0005666_abnormal_adipose_tissue1.46521398
34MP0005375_adipose_tissue_phenotype1.45099954
35MP0000003_abnormal_adipose_tissue1.43345035
36MP0004510_myositis1.41662138
37MP0000858_altered_metastatic_potential1.41588707
38MP0003436_decreased_susceptibility_to1.34883203
39MP0004947_skin_inflammation1.34826673
40MP0003172_abnormal_lysosome_physiology1.34112043
41MP0000350_abnormal_cell_proliferation1.32580981
42MP0004808_abnormal_hematopoietic_stem1.31988184
43MP0002396_abnormal_hematopoietic_system1.29377251
44MP0005621_abnormal_cell_physiology1.21032159
45MP0003279_aneurysm1.20293838
46MP0003763_abnormal_thymus_physiology1.18462206
47MP0009053_abnormal_anal_canal1.16963088
48MP0005257_abnormal_intraocular_pressure1.14876373
49MP0000759_abnormal_skeletal_muscle1.14857500
50MP0003656_abnormal_erythrocyte_physiolo1.13723863
51MP0002060_abnormal_skin_morphology1.10646366
52MP0001873_stomach_inflammation1.09956121
53MP0001346_abnormal_lacrimal_gland1.08887910
54MP0003123_paternal_imprinting1.07081457
55MP0003693_abnormal_embryo_hatching1.06541474
56MP0009672_abnormal_birth_weight1.06056405
57MP0000747_muscle_weakness1.05536489
58MP0003329_amyloid_beta_deposits1.05383095
59MP0010030_abnormal_orbit_morphology1.03348793
60MP0002080_prenatal_lethality1.01249457
61MP0005397_hematopoietic_system_phenotyp1.00378698
62MP0001545_abnormal_hematopoietic_system1.00378698
63MP0004272_abnormal_basement_membrane0.99815639
64MP0003077_abnormal_cell_cycle0.99624313
65MP0001915_intracranial_hemorrhage0.98352795
66MP0000490_abnormal_crypts_of0.94944338
67MP0005380_embryogenesis_phenotype0.94643358
68MP0001672_abnormal_embryogenesis/_devel0.94643358
69MP0000703_abnormal_thymus_morphology0.93805627
70MP0004381_abnormal_hair_follicle0.93305685
71MP0003984_embryonic_growth_retardation0.92667303
72MP0010630_abnormal_cardiac_muscle0.92592030
73MP0005023_abnormal_wound_healing0.91946555
74MP0009931_abnormal_skin_appearance0.90137675
75MP0001216_abnormal_epidermal_layer0.88252488
76MP0010352_gastrointestinal_tract_polyps0.88130079
77MP0002086_abnormal_extraembryonic_tissu0.87924647
78MP0002098_abnormal_vibrissa_morphology0.85902573
79MP0004087_abnormal_muscle_fiber0.85793356
80MP0000313_abnormal_cell_death0.85091340
81MP0002088_abnormal_embryonic_growth/wei0.84521698
82MP0000751_myopathy0.81718145
83MP0003191_abnormal_cellular_cholesterol0.81317098
84MP0000767_abnormal_smooth_muscle0.80853164
85MP0003942_abnormal_urinary_system0.80544757
86MP0005384_cellular_phenotype0.80305640
87MP0002398_abnormal_bone_marrow0.75804341
88MP0004957_abnormal_blastocyst_morpholog0.75395139
89MP0002085_abnormal_embryonic_tissue0.74621676
90MP0000681_abnormal_thyroid_gland0.73878032
91MP0000685_abnormal_immune_system0.73864603
92MP0002998_abnormal_bone_remodeling0.73608136
93MP0003115_abnormal_respiratory_system0.72620668
94MP0000467_abnormal_esophagus_morphology0.72123103
95MP0005508_abnormal_skeleton_morphology0.71659304
96MP0000579_abnormal_nail_morphology0.71162166
97MP0000750_abnormal_muscle_regeneration0.70488332
98MP0003634_abnormal_glial_cell0.69206510
99MP0000762_abnormal_tongue_morphology0.68144494
100MP0001697_abnormal_embryo_size0.67620881

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.96027778
2Obstructive sleep apnea (HP:0002870)3.38599925
3Ulnar bowing (HP:0003031)2.91722276
4Protrusio acetabuli (HP:0003179)2.89969362
5Insomnia (HP:0100785)2.80459568
6Achilles tendon contracture (HP:0001771)2.77140579
7Disproportionate tall stature (HP:0001519)2.66622922
8Broad face (HP:0000283)2.61456040
9Long palpebral fissure (HP:0000637)2.55104688
10Increased connective tissue (HP:0009025)2.53568753
11Distal lower limb amyotrophy (HP:0008944)2.53219155
12Premature rupture of membranes (HP:0001788)2.51204108
13Centrally nucleated skeletal muscle fibers (HP:0003687)2.45569839
14Genu recurvatum (HP:0002816)2.41343069
15Abnormality of the Achilles tendon (HP:0005109)2.40439564
16Shallow orbits (HP:0000586)2.37956918
17Reticulocytosis (HP:0001923)2.36034972
18Abnormality of the thoracic spine (HP:0100711)2.32481981
19Cerebral aneurysm (HP:0004944)2.30577579
20Fragile skin (HP:0001030)2.28033696
21Abnormality of the phalanges of the hallux (HP:0010057)2.23197984
22Abnormality of the distal phalanx of the thumb (HP:0009617)2.23113309
23Vertebral compression fractures (HP:0002953)2.18561955
24Broad distal phalanx of finger (HP:0009836)2.17269288
25Abnormal gallbladder physiology (HP:0012438)2.15089937
26Cholecystitis (HP:0001082)2.15089937
27Patellar dislocation (HP:0002999)2.13930476
28Deep palmar crease (HP:0006191)2.11050647
29Trismus (HP:0000211)2.09190461
30Increased variability in muscle fiber diameter (HP:0003557)2.09098483
31Flat acetabular roof (HP:0003180)2.08775427
32Hyperparathyroidism (HP:0000843)2.05687739
33Abnormality of the fingertips (HP:0001211)2.03734225
34Distal upper limb amyotrophy (HP:0007149)2.01451757
35Upper limb amyotrophy (HP:0009129)2.01451757
36Bowel incontinence (HP:0002607)2.01382889
37Hypercortisolism (HP:0001578)2.00928256
38Thoracic kyphosis (HP:0002942)1.99959843
39Progressive muscle weakness (HP:0003323)1.99619262
40Truncus arteriosus (HP:0001660)1.98671688
41Dysmetric saccades (HP:0000641)1.98130041
42Mitral regurgitation (HP:0001653)1.96455889
43Overriding aorta (HP:0002623)1.96064382
44Abnormality of skeletal muscle fiber size (HP:0012084)1.92558835
45Abnormal large intestine physiology (HP:0012700)1.92225710
46Hypertensive crisis (HP:0100735)1.90092321
47Premature skin wrinkling (HP:0100678)1.89014210
48Long eyelashes (HP:0000527)1.88080406
49Myopathic facies (HP:0002058)1.87446464
50Pointed chin (HP:0000307)1.86267977
51Germ cell neoplasia (HP:0100728)1.86201818
52Distal lower limb muscle weakness (HP:0009053)1.85561717
53Elfin facies (HP:0004428)1.85374360
54Atrophic scars (HP:0001075)1.85070232
55Bladder diverticulum (HP:0000015)1.83787672
56Renal duplication (HP:0000075)1.83097684
57Spinal rigidity (HP:0003306)1.82695822
58Cellulitis (HP:0100658)1.82172032
59Elbow flexion contracture (HP:0002987)1.81229333
60Thin bony cortex (HP:0002753)1.79194089
61Septate vagina (HP:0001153)1.79186588
62Lower limb amyotrophy (HP:0007210)1.78523320
63Mitral valve prolapse (HP:0001634)1.78170236
64Dislocated radial head (HP:0003083)1.78107414
65Difficulty climbing stairs (HP:0003551)1.77255953
66Peripheral hypomyelination (HP:0007182)1.75853645
67Hyperthyroidism (HP:0000836)1.75247262
68Cerebral inclusion bodies (HP:0100314)1.74257199
69Abnormality of the distal phalanges of the toes (HP:0010182)1.74107855
70Biconcave vertebral bodies (HP:0004586)1.73039114
71Arnold-Chiari malformation (HP:0002308)1.72005115
72Thin ribs (HP:0000883)1.70526399
73Abnormality of reticulocytes (HP:0004312)1.70286448
74Asymmetry of the thorax (HP:0001555)1.68969578
75Stridor (HP:0010307)1.68826779
76Blue sclerae (HP:0000592)1.68196206
77Segmental peripheral demyelination/remyelination (HP:0003481)1.67830108
78Abnormality of the radial head (HP:0003995)1.67082323
79Advanced eruption of teeth (HP:0006288)1.66784418
80Hypercalcemia (HP:0003072)1.66108154
81Ankyloglossia (HP:0010296)1.65818759
82Mildly elevated creatine phosphokinase (HP:0008180)1.61420633
83Atelectasis (HP:0100750)1.61387836
84Dilatation of the ascending aorta (HP:0005111)1.59760247
85Urethral obstruction (HP:0000796)1.59672382
86Selective tooth agenesis (HP:0001592)1.58719841
87Persistence of primary teeth (HP:0006335)1.58452865
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57051637
89Exercise-induced myalgia (HP:0003738)1.56615922
90Abnormality of the tricuspid valve (HP:0001702)1.56066238
91Polygenic inheritance (HP:0010982)1.56051128
92Sparse lateral eyebrow (HP:0005338)1.55067786
93Turricephaly (HP:0000262)1.52889236
94Cervical subluxation (HP:0003308)1.52832458
95Deviation of the hallux (HP:0010051)1.51457447
96Bowing of the arm (HP:0006488)1.51371563
97Bowed forearm bones (HP:0003956)1.51371563
98Hemorrhage of the eye (HP:0011885)1.51300910
99Hallux valgus (HP:0001822)1.51117668
100Precocious puberty (HP:0000826)1.50921861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.62686133
2CDK123.78458021
3SMG13.71333186
4PRPF4B3.48482608
5ICK3.19634451
6EEF2K3.03249842
7SIK12.98302097
8IRAK32.75304657
9ERN12.46306223
10MAP3K102.43603567
11NME22.04259310
12RIPK11.72246741
13TAOK21.66266307
14MAP2K31.63615854
15TTN1.54234111
16TAOK11.46725817
17ARAF1.41595957
18MAP3K131.41292730
19CAMK1D1.37410503
20PKN21.34287883
21MTOR1.32557662
22SIK21.30949847
23MAP3K31.26359616
24PDGFRA1.24594831
25MAP3K111.20376435
26FGFR41.19211558
27KSR21.16580366
28MARK21.16464222
29MAP4K11.15360632
30MAP3K91.13596398
31PRKD21.07932037
32EPHA21.07049993
33CDC42BPA1.04809556
34IRAK21.01456951
35MAP3K11.00684979
36LATS20.99372484
37TYRO30.99255645
38HIPK20.97790887
39PRKD30.95113459
40BRD40.92731217
41MAP3K80.92210143
42BRAF0.91936449
43CAMK1G0.85674664
44RPS6KA20.83765017
45PTK60.83543173
46CDK40.82981970
47RPS6KB20.82611339
48PIM20.82140467
49RPS6KL10.79679702
50RPS6KC10.79679702
51CDK70.77091267
52SIK30.76342451
53BMX0.74564160
54IRAK40.73632869
55PAK40.72292675
56RIPK40.70405175
57PTK20.68935202
58TESK10.68657300
59MOS0.67543767
60NTRK10.67125019
61LRRK20.66543575
62MAPK110.66068748
63MAP3K140.65918782
64PDPK10.65803865
65DDR20.64885048
66MAP2K20.64372338
67TBK10.60547652
68EPHB10.59881079
69CDK90.58059351
70RPS6KA60.57699528
71DMPK0.56242924
72AURKA0.53679410
73DYRK1B0.51371579
74TESK20.50969645
75LMTK20.49773285
76PAK20.47971992
77CDK60.46750660
78RPS6KA10.46088466
79CHUK0.45566455
80RAF10.44083030
81CAMKK10.43988364
82CLK10.43458759
83ILK0.42351374
84SGK30.41607570
85CHEK10.40226894
86AKT20.37918513
87CDK20.35516127
88MAPK120.35234383
89STK40.35144272
90MAP3K60.34090880
91MAPK100.32725178
92RET0.31057500
93SCYL20.30168158
94PDK10.29344084
95CDK11A0.28856472
96MST1R0.28659028
97ALK0.28471328
98MAP3K70.27228472
99STK100.26726273
100MAPK80.26261691

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.43162309
2Acute myeloid leukemia_Homo sapiens_hsa052212.36513538
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.17812020
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14064484
5Bladder cancer_Homo sapiens_hsa052192.04510735
6Non-small cell lung cancer_Homo sapiens_hsa052232.00164991
7Notch signaling pathway_Homo sapiens_hsa043301.95652682
8Pancreatic cancer_Homo sapiens_hsa052121.81301055
9B cell receptor signaling pathway_Homo sapiens_hsa046621.73471534
10Other glycan degradation_Homo sapiens_hsa005111.72820523
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.71989197
12VEGF signaling pathway_Homo sapiens_hsa043701.71619394
13Renal cell carcinoma_Homo sapiens_hsa052111.66565041
14Endometrial cancer_Homo sapiens_hsa052131.65519015
15Thyroid cancer_Homo sapiens_hsa052161.60803634
16Neurotrophin signaling pathway_Homo sapiens_hsa047221.56057727
17Prion diseases_Homo sapiens_hsa050201.50387798
18mTOR signaling pathway_Homo sapiens_hsa041501.47644877
19ErbB signaling pathway_Homo sapiens_hsa040121.40091913
20Glioma_Homo sapiens_hsa052141.36312822
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36130595
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32464162
23Insulin signaling pathway_Homo sapiens_hsa049101.29001730
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27928839
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.27006712
26Prostate cancer_Homo sapiens_hsa052151.26812260
27MicroRNAs in cancer_Homo sapiens_hsa052061.25269304
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20753562
29Small cell lung cancer_Homo sapiens_hsa052221.19537682
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18908274
31Hepatitis B_Homo sapiens_hsa051611.18793625
32Colorectal cancer_Homo sapiens_hsa052101.18793519
33Sulfur relay system_Homo sapiens_hsa041221.14960082
34Apoptosis_Homo sapiens_hsa042101.11781514
35Osteoclast differentiation_Homo sapiens_hsa043801.09295721
36Pentose phosphate pathway_Homo sapiens_hsa000301.08068559
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07864720
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07067346
39HTLV-I infection_Homo sapiens_hsa051661.05284014
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05219669
41TNF signaling pathway_Homo sapiens_hsa046681.04542671
42Fructose and mannose metabolism_Homo sapiens_hsa000511.01570183
43AMPK signaling pathway_Homo sapiens_hsa041520.99516452
44Prolactin signaling pathway_Homo sapiens_hsa049170.98830286
45Focal adhesion_Homo sapiens_hsa045100.98024746
46Proteoglycans in cancer_Homo sapiens_hsa052050.96361069
47Viral carcinogenesis_Homo sapiens_hsa052030.95467816
48T cell receptor signaling pathway_Homo sapiens_hsa046600.94893679
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.93309311
50Hepatitis C_Homo sapiens_hsa051600.93120674
51Influenza A_Homo sapiens_hsa051640.88979859
52GnRH signaling pathway_Homo sapiens_hsa049120.88088374
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88044221
54Estrogen signaling pathway_Homo sapiens_hsa049150.87206192
55HIF-1 signaling pathway_Homo sapiens_hsa040660.85051381
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.84860680
57Inositol phosphate metabolism_Homo sapiens_hsa005620.84084463
58Amoebiasis_Homo sapiens_hsa051460.83436468
59Shigellosis_Homo sapiens_hsa051310.82967580
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82564090
61Adherens junction_Homo sapiens_hsa045200.82466172
62Choline metabolism in cancer_Homo sapiens_hsa052310.82148014
63Toxoplasmosis_Homo sapiens_hsa051450.80983487
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.80874426
65Epstein-Barr virus infection_Homo sapiens_hsa051690.80257215
66Insulin resistance_Homo sapiens_hsa049310.80103523
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79784010
68Lysine degradation_Homo sapiens_hsa003100.78558982
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76956235
70mRNA surveillance pathway_Homo sapiens_hsa030150.76455166
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.75704236
72Endocytosis_Homo sapiens_hsa041440.75467216
73FoxO signaling pathway_Homo sapiens_hsa040680.75360819
74Spliceosome_Homo sapiens_hsa030400.74970093
75Herpes simplex infection_Homo sapiens_hsa051680.74660749
76DNA replication_Homo sapiens_hsa030300.74491737
77Biosynthesis of amino acids_Homo sapiens_hsa012300.73102175
78MAPK signaling pathway_Homo sapiens_hsa040100.71739630
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70999497
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70774255
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.70343322
82Cell cycle_Homo sapiens_hsa041100.70236931
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69438781
84Galactose metabolism_Homo sapiens_hsa000520.68061687
85Melanoma_Homo sapiens_hsa052180.68049469
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.66571125
87Measles_Homo sapiens_hsa051620.66250170
88Long-term potentiation_Homo sapiens_hsa047200.66128429
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65675891
90Pathways in cancer_Homo sapiens_hsa052000.63360517
91Salmonella infection_Homo sapiens_hsa051320.61383120
92Type II diabetes mellitus_Homo sapiens_hsa049300.59817517
93Melanogenesis_Homo sapiens_hsa049160.58526375
94Leishmaniasis_Homo sapiens_hsa051400.56372326
95Vibrio cholerae infection_Homo sapiens_hsa051100.54814317
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53143067
97Malaria_Homo sapiens_hsa051440.51786223
98Basal cell carcinoma_Homo sapiens_hsa052170.50919358
99Lysosome_Homo sapiens_hsa041420.50816688
100Tuberculosis_Homo sapiens_hsa051520.48835623

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