ZNF775

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.64386580
2translational termination (GO:0006415)6.07199231
3ribosomal small subunit biogenesis (GO:0042274)5.99241922
4ribosomal small subunit assembly (GO:0000028)5.67992198
5translational elongation (GO:0006414)5.30282001
6nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.94231833
7viral life cycle (GO:0019058)4.85080552
8cellular protein complex disassembly (GO:0043624)4.65132460
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45074612
10protein complex disassembly (GO:0043241)4.38800330
11regulation of chromatin binding (GO:0035561)4.38704783
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.36712997
13protein targeting to ER (GO:0045047)4.36639360
14cotranslational protein targeting to membrane (GO:0006613)4.31764569
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.17294614
16protein localization to endoplasmic reticulum (GO:0070972)4.14764920
17tongue development (GO:0043586)4.12058004
18macromolecular complex disassembly (GO:0032984)4.03813943
19maturation of SSU-rRNA (GO:0030490)3.98213751
20positive regulation of gamma-delta T cell activation (GO:0046645)3.93273521
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79700596
22translational initiation (GO:0006413)3.77892143
23negative regulation of erythrocyte differentiation (GO:0045647)3.75480941
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74604712
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.74604712
26modulation by symbiont of host immune response (GO:0052553)3.74604712
27positive regulation by symbiont of host defense response (GO:0052509)3.74604712
28modulation by symbiont of host defense response (GO:0052031)3.74604712
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74604712
30peptidyl-arginine omega-N-methylation (GO:0035247)3.70937828
31thymic T cell selection (GO:0045061)3.67331767
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64790076
33negative regulation of cell killing (GO:0031342)3.64790076
34negative regulation of granulocyte differentiation (GO:0030853)3.64742873
35mucosal-associated lymphoid tissue development (GO:0048537)3.64303890
36Peyers patch development (GO:0048541)3.64303890
37positive regulation of protein homooligomerization (GO:0032464)3.60580162
38positive regulation of T cell apoptotic process (GO:0070234)3.59388819
39positive thymic T cell selection (GO:0045059)3.56715352
40T cell migration (GO:0072678)3.48836217
41negative thymic T cell selection (GO:0045060)3.47940806
42peptidyl-arginine methylation (GO:0018216)3.42447707
43peptidyl-arginine N-methylation (GO:0035246)3.42447707
44negative T cell selection (GO:0043383)3.35485044
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27594071
46antigen processing and presentation of endogenous antigen (GO:0019883)3.26862813
47B cell receptor signaling pathway (GO:0050853)3.25533746
48forebrain morphogenesis (GO:0048853)3.22487344
49protein targeting to membrane (GO:0006612)3.21396088
50histone arginine methylation (GO:0034969)3.19978993
51regulation of interferon-beta biosynthetic process (GO:0045357)3.18783959
52negative regulation of DNA-templated transcription, elongation (GO:0032785)3.16711157
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14595339
54NIK/NF-kappaB signaling (GO:0038061)3.14099232
55nuclear-transcribed mRNA catabolic process (GO:0000956)3.10900097
56regulation of telomerase activity (GO:0051972)3.10189994
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.09032869
58mitochondrion transport along microtubule (GO:0047497)3.09032869
59establishment of mitochondrion localization (GO:0051654)3.03730385
60positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.02831919
61hypothalamus development (GO:0021854)3.00965555
62mRNA catabolic process (GO:0006402)2.99708584
633-UTR-mediated mRNA stabilization (GO:0070935)2.98021455
64T cell selection (GO:0045058)2.94078092
65negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.91392480
66cellular response to virus (GO:0098586)2.90892158
67regulation of B cell receptor signaling pathway (GO:0050855)2.87887690
68regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85181281
69positive T cell selection (GO:0043368)2.82625849
70regulation of monocyte differentiation (GO:0045655)2.80329658
71natural killer cell differentiation (GO:0001779)2.80023758
72activation of MAPKKK activity (GO:0000185)2.78457532
73RNA catabolic process (GO:0006401)2.77703384
74cytoplasmic sequestering of transcription factor (GO:0042994)2.77688871
75modulation by virus of host process (GO:0019054)2.76160806
76positive regulation of lymphocyte apoptotic process (GO:0070230)2.75915645
77negative regulation of telomerase activity (GO:0051974)2.74737450
78negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.73936223
79regulation of granulocyte differentiation (GO:0030852)2.73347004
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71947603
81mature B cell differentiation (GO:0002335)2.70204217
82protein-DNA complex disassembly (GO:0032986)2.67814525
83nucleosome disassembly (GO:0006337)2.67814525
84positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.67566238
85detection of bacterium (GO:0016045)2.67155277
86heart valve formation (GO:0003188)2.65041295
87ncRNA 3-end processing (GO:0043628)2.64838478
88heterochromatin organization (GO:0070828)2.63717240
89positive regulation of histone deacetylation (GO:0031065)2.60748240
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.60381532
91leukocyte aggregation (GO:0070486)2.60108320
92positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58847102
93activated T cell proliferation (GO:0050798)2.58279005
94regulation of gamma-delta T cell activation (GO:0046643)2.58213894
95formation of translation preinitiation complex (GO:0001731)2.57338444
96regulation of defense response to virus by virus (GO:0050690)2.57268944
97ribonucleoprotein complex biogenesis (GO:0022613)2.56976999
98ribosomal large subunit biogenesis (GO:0042273)2.56729633
99histone H4 deacetylation (GO:0070933)2.56678924
100regulation of interferon-gamma biosynthetic process (GO:0045072)2.54043568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.98530304
2VDR_21846776_ChIP-Seq_THP-1_Human3.43777089
3MYC_22102868_ChIP-Seq_BL_Human3.39057444
4EZH2_22144423_ChIP-Seq_EOC_Human2.75545460
5LXR_22292898_ChIP-Seq_THP-1_Human2.59162162
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.56665893
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41503059
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28793925
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27790721
10KDM2B_26808549_Chip-Seq_DND41_Human2.27486307
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20698889
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07898664
13P68_20966046_ChIP-Seq_HELA_Human1.95869917
14* MAF_26560356_Chip-Seq_TH2_Human1.94786182
15MAF_26560356_Chip-Seq_TH1_Human1.93315766
16TCF7_22412390_ChIP-Seq_EML_Mouse1.91713920
17* UTX_26944678_Chip-Seq_JUKART_Human1.87292407
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.86589881
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86451232
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82096382
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77633469
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.72385018
23CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71813131
24ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69626990
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69210018
26SA1_27219007_Chip-Seq_ERYTHROID_Human1.68563697
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.67000760
28KDM2B_26808549_Chip-Seq_K562_Human1.64627279
29* KDM2B_26808549_Chip-Seq_JURKAT_Human1.62915991
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.62113594
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61884432
32* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58022748
33CIITA_25753668_ChIP-Seq_RAJI_Human1.56715983
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54870405
35BCL6_27268052_Chip-Seq_Bcells_Human1.53775036
36VDR_24763502_ChIP-Seq_THP-1_Human1.50265100
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45146156
38* XRN2_22483619_ChIP-Seq_HELA_Human1.44967782
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41963686
40SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40647678
41BCOR_27268052_Chip-Seq_Bcells_Human1.40440427
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40107613
43CTCF_27219007_Chip-Seq_Bcells_Human1.38822213
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38721972
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38452932
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.37357411
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.36797960
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36632761
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35390282
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33534947
51SMC4_20622854_ChIP-Seq_HELA_Human1.32570541
52CTCF_26484167_Chip-Seq_Bcells_Mouse1.32117051
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32064246
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31584013
55SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31395739
56* NCOR1_26117541_ChIP-Seq_K562_Human1.27589342
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27191493
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25642461
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25245771
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24627325
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24538383
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23611739
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23485529
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.23049805
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21653608
66RACK7_27058665_Chip-Seq_MCF-7_Human1.21258045
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20616717
68CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19574699
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19343324
70PHF8_20622854_ChIP-Seq_HELA_Human1.18746600
71E2F1_20622854_ChIP-Seq_HELA_Human1.16946962
72SA1_27219007_Chip-Seq_Bcells_Human1.16708676
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15159096
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14464961
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13766514
76CREB1_26743006_Chip-Seq_LNCaP_Human1.12767061
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12321299
78* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11557972
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11111607
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10886334
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10127548
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09632508
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.09290944
84CTCF_21964334_Chip-Seq_Bcells_Human1.08645162
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.07996517
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07827624
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.07808793
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05131196
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04862138
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04798268
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04329322
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04242348
93ETS1_21867929_ChIP-Seq_TH2_Mouse1.02173979
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.01602781
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00867254
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00631929
97RARA_24833708_ChIP-Seq_LIVER_Mouse1.00525566
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00088127
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99238527
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98081955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.56239224
2MP0006292_abnormal_olfactory_placode3.52223530
3MP0009379_abnormal_foot_pigmentation3.48143014
4MP0003787_abnormal_imprinting2.68291172
5MP0002132_abnormal_respiratory_system2.64382507
6MP0002163_abnormal_gland_morphology2.63766802
7MP0003136_yellow_coat_color2.52164046
8MP0003123_paternal_imprinting2.47319674
9MP0009278_abnormal_bone_marrow2.44607418
10MP0005671_abnormal_response_to2.29903178
11MP0004859_abnormal_synaptic_plasticity2.27931408
12MP0001790_abnormal_immune_system2.24488760
13MP0005387_immune_system_phenotype2.24488760
14MP0002249_abnormal_larynx_morphology2.12519220
15MP0003763_abnormal_thymus_physiology2.04857662
16MP0001800_abnormal_humoral_immune2.02422111
17MP0009333_abnormal_splenocyte_physiolog1.95821646
18MP0000685_abnormal_immune_system1.93185951
19MP0003436_decreased_susceptibility_to1.91060641
20MP0000678_abnormal_parathyroid_gland1.88345016
21MP0001873_stomach_inflammation1.69847047
22MP0002398_abnormal_bone_marrow1.69290656
23MP0002420_abnormal_adaptive_immunity1.65331779
24MP0000703_abnormal_thymus_morphology1.64311614
25MP0003183_abnormal_peptide_metabolism1.64187250
26MP0001819_abnormal_immune_cell1.63601347
27MP0005000_abnormal_immune_tolerance1.60482411
28MP0001835_abnormal_antigen_presentation1.58416503
29MP0005645_abnormal_hypothalamus_physiol1.56130432
30MP0002723_abnormal_immune_serum1.55827011
31MP0004858_abnormal_nervous_system1.50460148
32MP0002452_abnormal_antigen_presenting1.47015593
33MP0000716_abnormal_immune_system1.46385210
34MP0005025_abnormal_response_to1.41901186
35MP0000778_abnormal_nervous_system1.38770283
36MP0005394_taste/olfaction_phenotype1.37829326
37MP0005499_abnormal_olfactory_system1.37829326
38MP0005423_abnormal_somatic_nervous1.36186718
39MP0000689_abnormal_spleen_morphology1.32053262
40MP0005377_hearing/vestibular/ear_phenot1.29135999
41MP0003878_abnormal_ear_physiology1.29135999
42MP0002722_abnormal_immune_system1.28890062
43MP0002429_abnormal_blood_cell1.28794793
44MP0001663_abnormal_digestive_system1.24736013
45MP0003880_abnormal_central_pattern1.24048589
46MP0001849_ear_inflammation1.20662382
47MP0003303_peritoneal_inflammation1.19252321
48MP0008260_abnormal_autophagy1.15619781
49MP0000490_abnormal_crypts_of1.14502769
50MP0004185_abnormal_adipocyte_glucose1.14501169
51MP0002822_catalepsy1.12368276
52MP0005379_endocrine/exocrine_gland_phen1.08616406
53MP0003121_genomic_imprinting1.08492315
54MP0002089_abnormal_postnatal_growth/wei1.05265639
55MP0003646_muscle_fatigue1.03193090
56MP0004130_abnormal_muscle_cell1.01613746
57MP0003172_abnormal_lysosome_physiology1.01137264
58MP0002405_respiratory_system_inflammati1.01020914
59MP0002419_abnormal_innate_immunity0.99725318
60MP0000049_abnormal_middle_ear0.96119215
61MP0002138_abnormal_hepatobiliary_system0.94386547
62MP0003122_maternal_imprinting0.93127003
63MP0005381_digestive/alimentary_phenotyp0.92045026
64MP0001502_abnormal_circadian_rhythm0.91558405
65MP0003938_abnormal_ear_development0.90712754
66MP0008789_abnormal_olfactory_epithelium0.89899894
67MP0003635_abnormal_synaptic_transmissio0.89889359
68MP0006276_abnormal_autonomic_nervous0.89448882
69MP0002396_abnormal_hematopoietic_system0.88218345
70MP0005397_hematopoietic_system_phenotyp0.87955482
71MP0001545_abnormal_hematopoietic_system0.87955482
72MP0010155_abnormal_intestine_physiology0.87823756
73MP0001485_abnormal_pinna_reflex0.86690625
74MP0000955_abnormal_spinal_cord0.86277241
75MP0004811_abnormal_neuron_physiology0.85529028
76MP0004142_abnormal_muscle_tone0.84226976
77MP0004381_abnormal_hair_follicle0.83785661
78MP0001348_abnormal_lacrimal_gland0.78949223
79MP0002063_abnormal_learning/memory/cond0.78808593
80MP0002148_abnormal_hypersensitivity_rea0.76372303
81MP0002277_abnormal_respiratory_mucosa0.75475137
82MP0003861_abnormal_nervous_system0.74925909
83MP0000313_abnormal_cell_death0.72833632
84MP0002152_abnormal_brain_morphology0.72194849
85MP0003111_abnormal_nucleus_morphology0.72168520
86MP0005451_abnormal_body_composition0.71976928
87MP0002160_abnormal_reproductive_system0.71780398
88MP0002928_abnormal_bile_duct0.70342758
89MP0000681_abnormal_thyroid_gland0.69682758
90MP0000631_abnormal_neuroendocrine_gland0.69174269
91MP0005075_abnormal_melanosome_morpholog0.68994202
92MP0008569_lethality_at_weaning0.67352954
93MP0003942_abnormal_urinary_system0.66709711
94MP0002210_abnormal_sex_determination0.65949899
95MP0009785_altered_susceptibility_to0.65837823
96MP0001986_abnormal_taste_sensitivity0.65312561
97MP0005666_abnormal_adipose_tissue0.64541218
98MP0000566_synostosis0.63036381
99MP0003866_abnormal_defecation0.62772264
100MP0003567_abnormal_fetal_cardiomyocyte0.62769927

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.45424554
2Abnormality of cells of the erythroid lineage (HP:0012130)4.23205565
3Reticulocytopenia (HP:0001896)3.82888239
4Abnormality of DNA repair (HP:0003254)3.77040176
5Agammaglobulinemia (HP:0004432)3.56179960
6Deep palmar crease (HP:0006191)3.48888822
7Panhypogammaglobulinemia (HP:0003139)3.31175597
8Abnormal number of erythroid precursors (HP:0012131)3.23606800
9Cellulitis (HP:0100658)3.12937073
10Abnormality of the aortic arch (HP:0012303)3.09813502
11Chronic obstructive pulmonary disease (HP:0006510)3.09568596
12Obstructive lung disease (HP:0006536)3.09568596
13Annular pancreas (HP:0001734)3.08934803
14Gastrointestinal stroma tumor (HP:0100723)3.05457031
15Obstructive sleep apnea (HP:0002870)2.98306266
16Pallor (HP:0000980)2.96215580
17Hyperthyroidism (HP:0000836)2.95937816
18Anomalous pulmonary venous return (HP:0010772)2.89600096
19Lymphopenia (HP:0001888)2.88551552
20Eczematoid dermatitis (HP:0000976)2.83827250
21Mediastinal lymphadenopathy (HP:0100721)2.81958753
22Impulsivity (HP:0100710)2.77756411
23Aplasia/Hypoplasia of the thymus (HP:0010515)2.77450575
24Increased IgE level (HP:0003212)2.76552176
25Meningitis (HP:0001287)2.75308270
26Truncus arteriosus (HP:0001660)2.64069295
27Recurrent sinusitis (HP:0011108)2.62626612
28Abnormality of cells of the lymphoid lineage (HP:0012140)2.54249164
29Abnormality of reticulocytes (HP:0004312)2.54012721
30Macrocytic anemia (HP:0001972)2.45114114
31Partial duplication of thumb phalanx (HP:0009944)2.44406978
32Spinal canal stenosis (HP:0003416)2.43402984
33Hypertensive crisis (HP:0100735)2.38627432
34Asplenia (HP:0001746)2.38487421
35Papilledema (HP:0001085)2.38099348
36Abnormality of the pulmonary veins (HP:0011718)2.35066047
37Maternal diabetes (HP:0009800)2.27159117
38Rib fusion (HP:0000902)2.27024657
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.24263271
40Thoracic kyphosis (HP:0002942)2.19211171
41Recurrent viral infections (HP:0004429)2.14533401
42Pointed chin (HP:0000307)2.12179015
43IgM deficiency (HP:0002850)2.11213700
44Colitis (HP:0002583)2.10918835
45Hypochromic anemia (HP:0001931)2.09722221
46Supernumerary ribs (HP:0005815)2.08928202
47Abnormality of the thoracic spine (HP:0100711)2.07541836
48Gastrointestinal inflammation (HP:0004386)2.07124280
49Long palpebral fissure (HP:0000637)2.05040788
50Seborrheic dermatitis (HP:0001051)2.03527882
51B lymphocytopenia (HP:0010976)2.02969745
52Myokymia (HP:0002411)2.02819985
53Severe combined immunodeficiency (HP:0004430)2.02060752
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01532029
55Turricephaly (HP:0000262)1.98471084
56Recurrent bacterial skin infections (HP:0005406)1.97876504
57Recurrent fungal infections (HP:0002841)1.97834093
58Metaphyseal cupping (HP:0003021)1.97679395
59Thrombocytosis (HP:0001894)1.96877138
60Broad distal phalanx of finger (HP:0009836)1.94784518
61Osteomalacia (HP:0002749)1.93582453
62Reticulocytosis (HP:0001923)1.92966423
63Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90407034
64Entropion (HP:0000621)1.90350260
65Poikiloderma (HP:0001029)1.89788898
66Supernumerary bones of the axial skeleton (HP:0009144)1.89652409
67Basal cell carcinoma (HP:0002671)1.89357140
68Facial hemangioma (HP:0000329)1.88872582
69Emphysema (HP:0002097)1.88847163
70Absent septum pellucidum (HP:0001331)1.88431911
71Partial duplication of the phalanx of hand (HP:0009999)1.87747882
72Increased IgM level (HP:0003496)1.87616873
73Sepsis (HP:0100806)1.87361329
74Mitral regurgitation (HP:0001653)1.86803391
75Flattened epiphyses (HP:0003071)1.85822795
76High anterior hairline (HP:0009890)1.83158207
77Elevated erythrocyte sedimentation rate (HP:0003565)1.81559786
78Nasal polyposis (HP:0100582)1.80098034
79Diastasis recti (HP:0001540)1.79779105
80Combined immunodeficiency (HP:0005387)1.78310090
81Polygenic inheritance (HP:0010982)1.73120094
82Recurrent otitis media (HP:0000403)1.71532258
83Cortical visual impairment (HP:0100704)1.70634445
84Trigonocephaly (HP:0000243)1.69683869
85Abnormality of the thymus (HP:0000777)1.69337788
8611 pairs of ribs (HP:0000878)1.68963293
87Abnormality of the fingertips (HP:0001211)1.67620725
88Bowel incontinence (HP:0002607)1.67018328
89Short femoral neck (HP:0100864)1.66126134
90Recurrent bronchitis (HP:0002837)1.65659731
91Encephalitis (HP:0002383)1.64514991
92Papilloma (HP:0012740)1.64423197
93Verrucae (HP:0200043)1.64423197
94Inflammation of the large intestine (HP:0002037)1.64382059
95Spontaneous hematomas (HP:0007420)1.64027075
96Colon cancer (HP:0003003)1.62956764
97Recurrent abscess formation (HP:0002722)1.62660254
98Hyperacusis (HP:0010780)1.62334484
99Abnormal delayed hypersensitivity skin test (HP:0002963)1.62170994
100Hyperglycinemia (HP:0002154)1.61666645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.67613606
2MAP4K13.50587883
3CDK193.45213519
4SMG13.24047614
5MAP3K112.50457923
6ERN12.50154686
7PRPF4B2.47245018
8RIPK42.46556449
9EEF2K2.18101961
10TRIB32.06227028
11TYRO31.92447440
12TNK21.87496193
13WNK41.77632997
14MARK21.77405252
15SIK21.69613825
16IRAK41.49880875
17FES1.49274326
18BTK1.48520978
19FGFR41.41928435
20NLK1.39059096
21BRAF1.36478587
22STK161.35865598
23SIK11.30985675
24MAP3K131.24862114
25NTRK21.20641708
26RPS6KL11.18956587
27RPS6KC11.18956587
28PASK1.18254205
29CAMK1D1.13022291
30ICK1.11719416
31NME21.06643701
32CDK41.06556761
33VRK21.06267788
34RPS6KA21.05268947
35PRKD21.04166362
36TYK21.01763905
37GRK61.01370873
38ARAF0.98809532
39RPS6KA60.98608463
40HIPK20.96647190
41SYK0.94464238
42PRKCQ0.93766712
43IKBKE0.93655292
44AURKA0.92504929
45DYRK1B0.92458301
46LRRK20.91293837
47BLK0.91260110
48UHMK10.89506472
49HCK0.87586022
50DYRK20.86878257
51CSK0.85988208
52MAP3K80.80088334
53BCKDK0.79844699
54MAPK120.79519210
55LYN0.78943635
56PRKD30.77444768
57CAMKK10.75425884
58MAP2K30.75125386
59TAOK30.74681714
60DAPK30.73681804
61TAF10.73542210
62CDC70.71647111
63TBK10.69723313
64WNK10.68008753
65MAP2K20.67988187
66MAP3K90.66215190
67KDR0.65702659
68ITK0.65346467
69SGK4940.65321770
70SGK2230.65321770
71PRKCH0.60717257
72STK110.60076771
73MAP2K70.58210327
74CAMK40.57314494
75MARK30.56444884
76DYRK30.55021936
77BMX0.54586202
78MAP3K10.54064045
79CAMK10.53435252
80PIM10.53222468
81MAPK70.53139157
82MAPK110.52773616
83CSF1R0.51920469
84ZAP700.51919532
85NEK20.51457114
86LCK0.51123174
87MAPK40.48958470
88TIE10.48431294
89MAP2K40.47134486
90CDC42BPA0.45792903
91PTK60.45218903
92PDPK10.43368901
93TAOK20.43344419
94JAK30.43193401
95TESK20.42384069
96PDK10.42034508
97ALK0.41868452
98MAP3K70.40337902
99RPS6KA10.38160469
100AKT10.37505652

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.50932794
2Primary immunodeficiency_Homo sapiens_hsa053403.38695322
3Notch signaling pathway_Homo sapiens_hsa043302.99467105
4B cell receptor signaling pathway_Homo sapiens_hsa046622.70404910
5Allograft rejection_Homo sapiens_hsa053302.08979113
6Autoimmune thyroid disease_Homo sapiens_hsa053201.97658978
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.91353426
8Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.87929060
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79587849
10Acute myeloid leukemia_Homo sapiens_hsa052211.71772994
11Graft-versus-host disease_Homo sapiens_hsa053321.71684086
12Sulfur relay system_Homo sapiens_hsa041221.63847756
13VEGF signaling pathway_Homo sapiens_hsa043701.55942683
14T cell receptor signaling pathway_Homo sapiens_hsa046601.48545957
15Base excision repair_Homo sapiens_hsa034101.46703714
16Herpes simplex infection_Homo sapiens_hsa051681.46701398
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42515984
18Systemic lupus erythematosus_Homo sapiens_hsa053221.34859548
19Viral myocarditis_Homo sapiens_hsa054161.34433003
20Leishmaniasis_Homo sapiens_hsa051401.33655846
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29477137
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.28824555
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26539811
24Osteoclast differentiation_Homo sapiens_hsa043801.21859568
25Type I diabetes mellitus_Homo sapiens_hsa049401.20842114
26Alcoholism_Homo sapiens_hsa050341.20178583
27Non-small cell lung cancer_Homo sapiens_hsa052231.18938420
28Chronic myeloid leukemia_Homo sapiens_hsa052201.18709336
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16576405
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15728920
31Antigen processing and presentation_Homo sapiens_hsa046121.14402809
32MAPK signaling pathway_Homo sapiens_hsa040101.12587216
33Asthma_Homo sapiens_hsa053101.10367483
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10306679
35Epstein-Barr virus infection_Homo sapiens_hsa051691.09802125
36Colorectal cancer_Homo sapiens_hsa052101.09702918
37Viral carcinogenesis_Homo sapiens_hsa052031.08975769
38Basal cell carcinoma_Homo sapiens_hsa052171.08651970
39Hepatitis B_Homo sapiens_hsa051611.08389583
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.07885651
41DNA replication_Homo sapiens_hsa030301.04666202
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.01916418
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00578086
44Measles_Homo sapiens_hsa051620.99199786
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98108823
46HTLV-I infection_Homo sapiens_hsa051660.96907000
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96054955
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95579668
49Influenza A_Homo sapiens_hsa051640.94911441
50Chemokine signaling pathway_Homo sapiens_hsa040620.92584367
51Long-term potentiation_Homo sapiens_hsa047200.92220336
52Biosynthesis of amino acids_Homo sapiens_hsa012300.91700684
53Hepatitis C_Homo sapiens_hsa051600.87153877
54Hedgehog signaling pathway_Homo sapiens_hsa043400.84456942
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84307678
56Spliceosome_Homo sapiens_hsa030400.80902072
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.80600703
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.80249651
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78180113
60Tuberculosis_Homo sapiens_hsa051520.77054498
61Cholinergic synapse_Homo sapiens_hsa047250.73468264
62Pancreatic cancer_Homo sapiens_hsa052120.73262120
63ErbB signaling pathway_Homo sapiens_hsa040120.72819548
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72725998
65Cardiac muscle contraction_Homo sapiens_hsa042600.71843436
66Choline metabolism in cancer_Homo sapiens_hsa052310.71477955
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66577420
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.66565785
69Melanogenesis_Homo sapiens_hsa049160.66365989
70mRNA surveillance pathway_Homo sapiens_hsa030150.66183640
71Renal cell carcinoma_Homo sapiens_hsa052110.65994852
72Ras signaling pathway_Homo sapiens_hsa040140.65965328
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64577002
74Hematopoietic cell lineage_Homo sapiens_hsa046400.64360761
75Axon guidance_Homo sapiens_hsa043600.63601998
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63544307
77African trypanosomiasis_Homo sapiens_hsa051430.63287142
78Apoptosis_Homo sapiens_hsa042100.60670371
79Endometrial cancer_Homo sapiens_hsa052130.60651734
80Endocytosis_Homo sapiens_hsa041440.58164542
81Insulin signaling pathway_Homo sapiens_hsa049100.57049215
82Pentose phosphate pathway_Homo sapiens_hsa000300.56921942
83Rap1 signaling pathway_Homo sapiens_hsa040150.56874494
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54576033
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53139925
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52796769
87Wnt signaling pathway_Homo sapiens_hsa043100.52505221
88Staphylococcus aureus infection_Homo sapiens_hsa051500.52417226
89Other glycan degradation_Homo sapiens_hsa005110.49812251
90Inositol phosphate metabolism_Homo sapiens_hsa005620.49492932
91GnRH signaling pathway_Homo sapiens_hsa049120.48906972
92Parkinsons disease_Homo sapiens_hsa050120.48721756
93Type II diabetes mellitus_Homo sapiens_hsa049300.48468889
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47525266
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46393233
96mTOR signaling pathway_Homo sapiens_hsa041500.43456888
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42180929
98Huntingtons disease_Homo sapiens_hsa050160.40881111
99Prolactin signaling pathway_Homo sapiens_hsa049170.40458506
100Prostate cancer_Homo sapiens_hsa052150.36839399

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