ZNF774

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.65707274
2response to pheromone (GO:0019236)4.62735727
3L-fucose catabolic process (GO:0042355)4.35816626
4fucose catabolic process (GO:0019317)4.35816626
5L-fucose metabolic process (GO:0042354)4.35816626
6indole-containing compound catabolic process (GO:0042436)4.04304165
7indolalkylamine catabolic process (GO:0046218)4.04304165
8tryptophan catabolic process (GO:0006569)4.04304165
9indolalkylamine metabolic process (GO:0006586)4.04085061
10kynurenine metabolic process (GO:0070189)3.91567214
11tryptophan metabolic process (GO:0006568)3.84570968
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66978805
13DNA deamination (GO:0045006)3.62157779
14epithelial cilium movement (GO:0003351)3.45651739
15detection of light stimulus involved in visual perception (GO:0050908)3.44123673
16detection of light stimulus involved in sensory perception (GO:0050962)3.44123673
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43100153
18cellular ketone body metabolic process (GO:0046950)3.24879015
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.21008976
20NADH dehydrogenase complex assembly (GO:0010257)3.21008976
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21008976
22indole-containing compound metabolic process (GO:0042430)3.19666073
23protein polyglutamylation (GO:0018095)3.14464663
24neural tube formation (GO:0001841)3.12957936
25gamma-aminobutyric acid transport (GO:0015812)3.12438441
26piRNA metabolic process (GO:0034587)3.11935533
27protein complex biogenesis (GO:0070271)3.10736513
28primary amino compound metabolic process (GO:1901160)3.10685251
29negative regulation of mast cell activation (GO:0033004)3.09072239
30cornea development in camera-type eye (GO:0061303)3.08351622
31nephron tubule morphogenesis (GO:0072078)3.02908047
32nephron epithelium morphogenesis (GO:0072088)3.02908047
33negative regulation of telomere maintenance (GO:0032205)2.99430292
34negative regulation of cytosolic calcium ion concentration (GO:0051481)2.99122505
35behavioral response to ethanol (GO:0048149)2.98175090
36sulfation (GO:0051923)2.97222662
37kidney morphogenesis (GO:0060993)2.96965783
38water-soluble vitamin biosynthetic process (GO:0042364)2.94255461
39platelet dense granule organization (GO:0060155)2.90303310
40ketone body metabolic process (GO:1902224)2.89703884
41preassembly of GPI anchor in ER membrane (GO:0016254)2.87508686
42cilium movement (GO:0003341)2.87478814
43neuronal action potential (GO:0019228)2.85772444
44serotonin metabolic process (GO:0042428)2.84785216
45mitochondrial respiratory chain complex assembly (GO:0033108)2.83494396
46axoneme assembly (GO:0035082)2.82442038
47negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82242785
48protein K11-linked deubiquitination (GO:0035871)2.81437467
49regulation of cilium movement (GO:0003352)2.77792362
50amine catabolic process (GO:0009310)2.77779630
51cellular biogenic amine catabolic process (GO:0042402)2.77779630
52somite development (GO:0061053)2.75476348
53respiratory chain complex IV assembly (GO:0008535)2.73691442
54dopamine transport (GO:0015872)2.72875544
55regulation of neurotransmitter uptake (GO:0051580)2.71165239
56DNA methylation involved in gamete generation (GO:0043046)2.70818226
57nonmotile primary cilium assembly (GO:0035058)2.70640879
58multicellular organism reproduction (GO:0032504)2.69415492
59regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67955007
60pyrimidine nucleobase catabolic process (GO:0006208)2.66711384
61glycerophospholipid catabolic process (GO:0046475)2.66440985
62regulation of action potential (GO:0098900)2.65820958
63cilium morphogenesis (GO:0060271)2.64804377
64rhodopsin mediated signaling pathway (GO:0016056)2.63810857
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63579405
66cAMP catabolic process (GO:0006198)2.63446190
67cilium or flagellum-dependent cell motility (GO:0001539)2.62398884
68peristalsis (GO:0030432)2.61094318
69synaptic transmission, cholinergic (GO:0007271)2.60010597
70transmission of nerve impulse (GO:0019226)2.58704000
71reflex (GO:0060004)2.57715648
72protein localization to cilium (GO:0061512)2.57600511
73oxidative demethylation (GO:0070989)2.57517460
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56942532
75regulation of hippo signaling (GO:0035330)2.55980375
76cilium organization (GO:0044782)2.55716927
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55123129
78spinal cord motor neuron differentiation (GO:0021522)2.54596168
79DNA demethylation (GO:0080111)2.51535028
80photoreceptor cell maintenance (GO:0045494)2.50791419
81adaptation of signaling pathway (GO:0023058)2.50027076
82retinal cone cell development (GO:0046549)2.48796873
83sperm motility (GO:0030317)2.48561762
84negative regulation of systemic arterial blood pressure (GO:0003085)2.48499927
85auditory receptor cell stereocilium organization (GO:0060088)2.48108885
86cilium assembly (GO:0042384)2.46089290
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44857703
88positive regulation of fatty acid transport (GO:2000193)2.44639975
89cytochrome complex assembly (GO:0017004)2.43327943
90renal tubule morphogenesis (GO:0061333)2.43119832
91cyclic nucleotide catabolic process (GO:0009214)2.41320176
92nucleobase catabolic process (GO:0046113)2.41160277
93NAD biosynthetic process (GO:0009435)2.41000396
94phasic smooth muscle contraction (GO:0014821)2.40726824
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40163988
96neuronal action potential propagation (GO:0019227)2.39908806
97intraciliary transport (GO:0042073)2.39347201
98regulation of hexokinase activity (GO:1903299)2.37592273
99regulation of glucokinase activity (GO:0033131)2.37592273
100mannosylation (GO:0097502)2.36399723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.97889663
2VDR_22108803_ChIP-Seq_LS180_Human3.08419039
3EZH2_22144423_ChIP-Seq_EOC_Human3.08208090
4GBX2_23144817_ChIP-Seq_PC3_Human2.93244301
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88850989
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79166488
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71114465
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48142923
9IGF1R_20145208_ChIP-Seq_DFB_Human2.41952670
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29772999
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21285186
12FUS_26573619_Chip-Seq_HEK293_Human2.11281964
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03592391
14EWS_26573619_Chip-Seq_HEK293_Human1.99692416
15P300_19829295_ChIP-Seq_ESCs_Human1.96735465
16ER_23166858_ChIP-Seq_MCF-7_Human1.93191181
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.93086241
18TAF15_26573619_Chip-Seq_HEK293_Human1.87040621
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78992183
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78111442
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64347247
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62407729
23BCAT_22108803_ChIP-Seq_LS180_Human1.59797318
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59747815
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.58552404
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58274621
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57681293
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54391475
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53289066
30STAT3_23295773_ChIP-Seq_U87_Human1.52847732
31REST_21632747_ChIP-Seq_MESCs_Mouse1.52834148
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52694166
33CBP_20019798_ChIP-Seq_JUKART_Human1.52694166
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.52213992
35SMAD4_21799915_ChIP-Seq_A2780_Human1.51382304
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.50309293
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49751439
38TP53_22573176_ChIP-Seq_HFKS_Human1.49504521
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48995886
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48995886
41AR_25329375_ChIP-Seq_VCAP_Human1.47520738
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43523766
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43221906
44TCF4_23295773_ChIP-Seq_U87_Human1.39900385
45IRF1_19129219_ChIP-ChIP_H3396_Human1.38766339
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37652654
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37066589
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35240461
49SOX2_19829295_ChIP-Seq_ESCs_Human1.34970005
50NANOG_19829295_ChIP-Seq_ESCs_Human1.34970005
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.33152787
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.32189437
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30849645
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.28812854
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28812854
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28733854
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28334145
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27360079
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26684369
60AR_21572438_ChIP-Seq_LNCaP_Human1.25544058
61TCF4_22108803_ChIP-Seq_LS180_Human1.23622947
62RUNX2_22187159_ChIP-Seq_PCA_Human1.23041212
63RNF2_27304074_Chip-Seq_NSC_Mouse1.23027699
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.21787317
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19817331
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19258908
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18999388
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18414948
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17856636
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.17792930
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17134365
72HOXB7_26014856_ChIP-Seq_BT474_Human1.17112387
73NCOR_22424771_ChIP-Seq_293T_Human1.17023442
74MYC_18940864_ChIP-ChIP_HL60_Human1.17014935
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16079231
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14690501
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.14668269
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.13917925
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.12523353
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.10196749
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09668206
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07499428
83AR_20517297_ChIP-Seq_VCAP_Human1.06772835
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.05400991
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05326713
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05081489
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.02677097
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01824430
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.00556907
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.99417789
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99395053
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.98889815
93JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98159206
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97122265
95EZH2_27304074_Chip-Seq_ESCs_Mouse0.96606950
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96579564
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96474802
98DROSHA_22980978_ChIP-Seq_HELA_Human0.95652434
99P53_22387025_ChIP-Seq_ESCs_Mouse0.94916335
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94691545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.06400098
2MP0003646_muscle_fatigue2.88148418
3MP0008877_abnormal_DNA_methylation2.51362160
4MP0005551_abnormal_eye_electrophysiolog2.44056331
5MP0002102_abnormal_ear_morphology2.27876709
6MP0001968_abnormal_touch/_nociception2.27263072
7MP0003136_yellow_coat_color2.22401516
8MP0008872_abnormal_physiological_respon2.19638299
9MP0005646_abnormal_pituitary_gland2.15784359
10MP0009046_muscle_twitch2.02254872
11MP0002837_dystrophic_cardiac_calcinosis1.98251705
12MP0009745_abnormal_behavioral_response1.97396759
13MP0006292_abnormal_olfactory_placode1.96815621
14MP0004043_abnormal_pH_regulation1.96394266
15MP0005645_abnormal_hypothalamus_physiol1.91149945
16MP0002736_abnormal_nociception_after1.87031064
17MP0000372_irregular_coat_pigmentation1.84788833
18MP0000569_abnormal_digit_pigmentation1.84064437
19MP0003787_abnormal_imprinting1.81322091
20MP0001501_abnormal_sleep_pattern1.78188384
21MP0005253_abnormal_eye_physiology1.77491892
22MP0002272_abnormal_nervous_system1.76318053
23MP0006072_abnormal_retinal_apoptosis1.76066014
24MP0008875_abnormal_xenobiotic_pharmacok1.74731816
25MP0001986_abnormal_taste_sensitivity1.74540272
26MP0004142_abnormal_muscle_tone1.74140406
27MP0004885_abnormal_endolymph1.73002718
28MP0002876_abnormal_thyroid_physiology1.72347755
29MP0002638_abnormal_pupillary_reflex1.71071508
30MP0002735_abnormal_chemical_nociception1.70374844
31MP0001485_abnormal_pinna_reflex1.70018587
32MP0004147_increased_porphyrin_level1.68021806
33MP0003880_abnormal_central_pattern1.59154969
34MP0006276_abnormal_autonomic_nervous1.55295920
35MP0000631_abnormal_neuroendocrine_gland1.54740220
36MP0002653_abnormal_ependyma_morphology1.51760909
37MP0002938_white_spotting1.50169263
38MP0001486_abnormal_startle_reflex1.49596604
39MP0005084_abnormal_gallbladder_morpholo1.49527844
40MP0005410_abnormal_fertilization1.45911324
41MP0004145_abnormal_muscle_electrophysio1.45310777
42MP0001529_abnormal_vocalization1.42155289
43MP0000427_abnormal_hair_cycle1.41063995
44MP0002064_seizures1.38613799
45MP0002572_abnormal_emotion/affect_behav1.36864608
46MP0002928_abnormal_bile_duct1.36301248
47MP0004742_abnormal_vestibular_system1.35828259
48MP0003011_delayed_dark_adaptation1.31336702
49MP0002557_abnormal_social/conspecific_i1.31251512
50MP0001970_abnormal_pain_threshold1.28094473
51MP0002822_catalepsy1.28007257
52MP0004133_heterotaxia1.27032553
53MP0002733_abnormal_thermal_nociception1.26593857
54MP0002234_abnormal_pharynx_morphology1.25943388
55MP0003283_abnormal_digestive_organ1.25352589
56MP0000383_abnormal_hair_follicle1.23532975
57MP0004924_abnormal_behavior1.22291133
58MP0005386_behavior/neurological_phenoty1.22291133
59MP0001984_abnormal_olfaction1.18363308
60MP0002067_abnormal_sensory_capabilities1.18131333
61MP0010386_abnormal_urinary_bladder1.18047410
62MP0005167_abnormal_blood-brain_barrier1.17059136
63MP0001905_abnormal_dopamine_level1.14227161
64MP0003635_abnormal_synaptic_transmissio1.12573223
65MP0005377_hearing/vestibular/ear_phenot1.10847421
66MP0003878_abnormal_ear_physiology1.10847421
67MP0002063_abnormal_learning/memory/cond1.10132195
68MP0005174_abnormal_tail_pigmentation1.05302015
69MP0003718_maternal_effect1.05188019
70MP0004215_abnormal_myocardial_fiber1.03435786
71MP0005171_absent_coat_pigmentation0.99812922
72MP0002138_abnormal_hepatobiliary_system0.99488028
73MP0005389_reproductive_system_phenotype0.99189688
74MP0000026_abnormal_inner_ear0.99049534
75MP0003137_abnormal_impulse_conducting0.98879144
76MP0005083_abnormal_biliary_tract0.96603436
77MP0000230_abnormal_systemic_arterial0.96521994
78MP0003698_abnormal_male_reproductive0.95285234
79MP0005195_abnormal_posterior_eye0.94275748
80MP0002734_abnormal_mechanical_nocicepti0.93951167
81MP0005085_abnormal_gallbladder_physiolo0.93224067
82MP0008775_abnormal_heart_ventricle0.92362522
83MP0003252_abnormal_bile_duct0.92190731
84MP0002184_abnormal_innervation0.91464736
85MP0008995_early_reproductive_senescence0.89413637
86MP0002277_abnormal_respiratory_mucosa0.88169517
87MP0002160_abnormal_reproductive_system0.88005028
88MP0002752_abnormal_somatic_nervous0.86599220
89MP0001963_abnormal_hearing_physiology0.86340354
90MP0002163_abnormal_gland_morphology0.84781643
91MP0001919_abnormal_reproductive_system0.84697608
92MP0005379_endocrine/exocrine_gland_phen0.84074217
93MP0002229_neurodegeneration0.83348396
94MP0004085_abnormal_heartbeat0.83004348
95MP0005670_abnormal_white_adipose0.82492652
96MP0001929_abnormal_gametogenesis0.81568181
97MP0005332_abnormal_amino_acid0.80505158
98MP0002751_abnormal_autonomic_nervous0.80112822
99MP0001502_abnormal_circadian_rhythm0.78099513
100MP0003119_abnormal_digestive_system0.77965354

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.34540618
2Abnormality of midbrain morphology (HP:0002418)4.10559029
3Molar tooth sign on MRI (HP:0002419)4.10559029
4Congenital stationary night blindness (HP:0007642)4.01885850
5Pancreatic fibrosis (HP:0100732)3.90287832
6True hermaphroditism (HP:0010459)3.86394536
7Nephronophthisis (HP:0000090)3.76381479
8Type II lissencephaly (HP:0007260)3.37142854
9Abnormality of the renal cortex (HP:0011035)3.36736176
10Abnormality of the renal medulla (HP:0100957)3.32726895
11Attenuation of retinal blood vessels (HP:0007843)3.25264108
12Hyperventilation (HP:0002883)3.13307407
13Medial flaring of the eyebrow (HP:0010747)3.08176209
14Tubular atrophy (HP:0000092)2.92688979
15Inability to walk (HP:0002540)2.86369117
16Chronic hepatic failure (HP:0100626)2.75626823
17Abolished electroretinogram (ERG) (HP:0000550)2.73429520
18Abnormal rod and cone electroretinograms (HP:0008323)2.72946106
19Cystic liver disease (HP:0006706)2.70844145
20Polydipsia (HP:0001959)2.67059124
21Abnormal drinking behavior (HP:0030082)2.67059124
22Pendular nystagmus (HP:0012043)2.63559285
23Large for gestational age (HP:0001520)2.56452376
24Gaze-evoked nystagmus (HP:0000640)2.51963132
25Progressive inability to walk (HP:0002505)2.51821046
26Cerebellar dysplasia (HP:0007033)2.50429206
27Progressive cerebellar ataxia (HP:0002073)2.48732769
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45828450
29Abnormality of alanine metabolism (HP:0010916)2.45828450
30Hyperalaninemia (HP:0003348)2.45828450
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.41363285
32Absent/shortened dynein arms (HP:0200106)2.41363285
33Gait imbalance (HP:0002141)2.39722052
34Lissencephaly (HP:0001339)2.39456989
35Sclerocornea (HP:0000647)2.39018463
36Genetic anticipation (HP:0003743)2.39001910
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.38541975
383-Methylglutaconic aciduria (HP:0003535)2.33112926
39Abnormality of the pons (HP:0007361)2.32883953
40Congenital primary aphakia (HP:0007707)2.32613344
41Renal cortical cysts (HP:0000803)2.27936879
42Increased corneal curvature (HP:0100692)2.26902654
43Keratoconus (HP:0000563)2.26902654
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26805775
45Bony spicule pigmentary retinopathy (HP:0007737)2.26033458
46Chorioretinal atrophy (HP:0000533)2.25373059
47Birth length less than 3rd percentile (HP:0003561)2.24483729
48Decreased central vision (HP:0007663)2.22850222
49Hypothermia (HP:0002045)2.21161001
50Patellar aplasia (HP:0006443)2.18000709
51Hypoplasia of the pons (HP:0012110)2.17390363
52Protruding tongue (HP:0010808)2.13635842
53Broad-based gait (HP:0002136)2.13341189
54Congenital hepatic fibrosis (HP:0002612)2.12859028
55Nephrogenic diabetes insipidus (HP:0009806)2.11698467
56Aplasia/Hypoplasia of the patella (HP:0006498)2.11639439
57Congenital sensorineural hearing impairment (HP:0008527)2.11578142
58Polyuria (HP:0000103)2.09856958
59Febrile seizures (HP:0002373)2.08178071
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05453383
61Abnormal respiratory epithelium morphology (HP:0012253)2.02834854
62Abnormal respiratory motile cilium morphology (HP:0005938)2.02834854
63Abnormal ciliary motility (HP:0012262)2.01456799
64Furrowed tongue (HP:0000221)2.01415741
65Pachygyria (HP:0001302)2.01169187
66Hemiparesis (HP:0001269)2.00880996
67Anencephaly (HP:0002323)2.00571553
68Methylmalonic acidemia (HP:0002912)1.99333086
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.99106293
70Increased CSF lactate (HP:0002490)1.98575609
71Bile duct proliferation (HP:0001408)1.98100654
72Abnormal biliary tract physiology (HP:0012439)1.98100654
73Decreased circulating renin level (HP:0003351)1.96958171
74Genital tract atresia (HP:0001827)1.96719804
75Mitochondrial inheritance (HP:0001427)1.96594207
76Male pseudohermaphroditism (HP:0000037)1.93806558
77Vaginal atresia (HP:0000148)1.90701391
78Absent speech (HP:0001344)1.89417775
79Stomach cancer (HP:0012126)1.87000464
80Tachypnea (HP:0002789)1.86201396
81Optic nerve hypoplasia (HP:0000609)1.86067500
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84051524
83Clumsiness (HP:0002312)1.83218595
84Acute necrotizing encephalopathy (HP:0006965)1.83066774
85Severe muscular hypotonia (HP:0006829)1.82370427
86Postaxial foot polydactyly (HP:0001830)1.82287002
87Ketosis (HP:0001946)1.81505305
88Ketoacidosis (HP:0001993)1.80655608
89Abnormality of macular pigmentation (HP:0008002)1.80222550
90Congenital, generalized hypertrichosis (HP:0004540)1.77809931
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.77361635
92Poor coordination (HP:0002370)1.76766522
93Abnormal urine output (HP:0012590)1.76393124
94Abnormality of the renal collecting system (HP:0004742)1.75796350
95Methylmalonic aciduria (HP:0012120)1.74088831
96Agitation (HP:0000713)1.73636669
97Optic disc pallor (HP:0000543)1.73206364
98Short tibia (HP:0005736)1.71199827
99Fair hair (HP:0002286)1.70955224
100Acute encephalopathy (HP:0006846)1.69389623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.86934645
2BMPR1B3.50852740
3ADRBK23.20827019
4ACVR1B3.10873180
5MAP4K23.00166293
6ZAK2.73124098
7TLK12.47654880
8TAOK32.37634228
9WNK32.37615318
10STK162.36436549
11WNK42.30172988
12GRK12.29874569
13PINK12.11364955
14INSRR1.96640820
15MAP3K41.93087978
16NUAK11.84840867
17DAPK21.84406736
18MAPK131.80088755
19CASK1.71505936
20TXK1.46947811
21OXSR11.44302932
22MAP2K71.41498519
23STK391.32833368
24TNIK1.21124076
25PAK31.18251987
26TGFBR11.18073329
27NTRK31.16014360
28ADRBK11.15604693
29STK38L1.10299942
30CAMKK21.03226392
31PTK2B1.02313640
32VRK11.00803172
33PNCK0.98636871
34PRKCG0.98017624
35MARK10.97131940
36PRKCE0.95332295
37MKNK20.93661386
38PHKG20.93197166
39PHKG10.93197166
40TRIM280.92621214
41BCKDK0.84863884
42EPHA40.83894942
43MAPKAPK30.83849108
44MAPK150.83567996
45PIK3CA0.83342036
46DYRK20.81269329
47BRSK20.75707298
48OBSCN0.75040776
49PLK20.71317602
50RPS6KA50.71121856
51MAP2K60.69344666
52TIE10.69222593
53PKN10.67130415
54NTRK20.66775096
55CSNK1G20.65386316
56NME10.64770845
57MUSK0.63779850
58MAPKAPK50.62865727
59CSNK1G10.60365423
60CAMK10.59864375
61PLK40.57917929
62CSNK1G30.57663069
63EPHA30.57513377
64CAMK2A0.56909234
65PRKCQ0.55812198
66MAP2K40.55590031
67CSNK1A1L0.55490843
68FGFR20.54960866
69IKBKB0.53576000
70NEK20.53299793
71AKT30.49873577
72PIK3CG0.48927494
73PRKACA0.46396826
74PRKAA10.46289971
75SIK20.45190527
76ITK0.45014649
77CSNK1A10.43837211
78PRKAA20.43732962
79PRKCI0.43631311
80ERBB30.42468997
81KIT0.41484007
82STK110.39784920
83BCR0.39534144
84TEC0.38870974
85PRKCZ0.38690589
86CAMK40.37787041
87IRAK10.37591638
88WEE10.35997517
89CAMK1D0.34169387
90WNK10.34166617
91CHUK0.33641849
92TAF10.32640689
93PRKG10.32265707
94GRK70.31846136
95PRKCA0.31671896
96MKNK10.31507210
97NLK0.30906015
98CSNK1D0.29895733
99CHEK20.29637718
100STK30.29173876

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.93403285
2Linoleic acid metabolism_Homo sapiens_hsa005912.58260069
3Nicotine addiction_Homo sapiens_hsa050332.51157175
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49351120
5Nitrogen metabolism_Homo sapiens_hsa009102.45312819
6Butanoate metabolism_Homo sapiens_hsa006502.43314342
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39013121
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.32810414
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.23216421
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16012170
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10603078
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09197880
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04713827
14Selenocompound metabolism_Homo sapiens_hsa004501.99154561
15Oxidative phosphorylation_Homo sapiens_hsa001901.97774673
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96480713
17Tryptophan metabolism_Homo sapiens_hsa003801.89233107
18Ether lipid metabolism_Homo sapiens_hsa005651.74404171
19Fanconi anemia pathway_Homo sapiens_hsa034601.59575087
20Homologous recombination_Homo sapiens_hsa034401.57780109
21Morphine addiction_Homo sapiens_hsa050321.55068847
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55034118
23Olfactory transduction_Homo sapiens_hsa047401.53718233
24RNA polymerase_Homo sapiens_hsa030201.51760101
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43841358
26Parkinsons disease_Homo sapiens_hsa050121.43412094
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42537449
28Taste transduction_Homo sapiens_hsa047421.42195840
29ABC transporters_Homo sapiens_hsa020101.40206618
30Basal transcription factors_Homo sapiens_hsa030221.34903689
31Caffeine metabolism_Homo sapiens_hsa002321.30446226
32Insulin secretion_Homo sapiens_hsa049111.25094761
33Propanoate metabolism_Homo sapiens_hsa006401.23897778
34GABAergic synapse_Homo sapiens_hsa047271.22044515
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.18608598
36Cardiac muscle contraction_Homo sapiens_hsa042601.14320995
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13633200
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.12820927
39Circadian entrainment_Homo sapiens_hsa047131.12257370
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11118898
41Protein export_Homo sapiens_hsa030601.09787456
42Chemical carcinogenesis_Homo sapiens_hsa052041.06426817
43Huntingtons disease_Homo sapiens_hsa050161.05958133
44Glutamatergic synapse_Homo sapiens_hsa047241.05458508
45Serotonergic synapse_Homo sapiens_hsa047261.05440745
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03671559
47RNA degradation_Homo sapiens_hsa030180.99859748
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.99723279
49Peroxisome_Homo sapiens_hsa041460.98638348
50Regulation of autophagy_Homo sapiens_hsa041400.97918910
51Ovarian steroidogenesis_Homo sapiens_hsa049130.97808618
52Arachidonic acid metabolism_Homo sapiens_hsa005900.97200486
53One carbon pool by folate_Homo sapiens_hsa006700.95114149
54Sulfur metabolism_Homo sapiens_hsa009200.94547403
55Glycerolipid metabolism_Homo sapiens_hsa005610.93805891
56Calcium signaling pathway_Homo sapiens_hsa040200.92325556
57Salivary secretion_Homo sapiens_hsa049700.89747270
58beta-Alanine metabolism_Homo sapiens_hsa004100.89209064
59Alzheimers disease_Homo sapiens_hsa050100.88859774
60Retinol metabolism_Homo sapiens_hsa008300.85148365
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79081676
62Collecting duct acid secretion_Homo sapiens_hsa049660.76658401
63Purine metabolism_Homo sapiens_hsa002300.75052957
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73805626
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72870023
66Fat digestion and absorption_Homo sapiens_hsa049750.70042835
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69491965
68Dopaminergic synapse_Homo sapiens_hsa047280.67777067
69Cocaine addiction_Homo sapiens_hsa050300.66056429
70Histidine metabolism_Homo sapiens_hsa003400.64918043
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61274952
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.59991430
73Metabolic pathways_Homo sapiens_hsa011000.58848023
74Circadian rhythm_Homo sapiens_hsa047100.57701825
75Amphetamine addiction_Homo sapiens_hsa050310.56673372
76cAMP signaling pathway_Homo sapiens_hsa040240.54829589
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51689653
78Mineral absorption_Homo sapiens_hsa049780.50338041
79Pyrimidine metabolism_Homo sapiens_hsa002400.48984578
80Dorso-ventral axis formation_Homo sapiens_hsa043200.48510878
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.45809099
82Fatty acid biosynthesis_Homo sapiens_hsa000610.45795906
83Graft-versus-host disease_Homo sapiens_hsa053320.45640038
84Oxytocin signaling pathway_Homo sapiens_hsa049210.45448975
85Type I diabetes mellitus_Homo sapiens_hsa049400.45150468
86Cholinergic synapse_Homo sapiens_hsa047250.44303061
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44268033
88Sulfur relay system_Homo sapiens_hsa041220.43461388
89Asthma_Homo sapiens_hsa053100.42780975
90Hedgehog signaling pathway_Homo sapiens_hsa043400.40155614
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39682411
92Renin secretion_Homo sapiens_hsa049240.39621702
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39325850
94Primary immunodeficiency_Homo sapiens_hsa053400.38580081
95Vitamin digestion and absorption_Homo sapiens_hsa049770.37779361
96Long-term depression_Homo sapiens_hsa047300.37624511
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37514631
98Systemic lupus erythematosus_Homo sapiens_hsa053220.37280289
99Gastric acid secretion_Homo sapiens_hsa049710.37051372
100Synaptic vesicle cycle_Homo sapiens_hsa047210.36640268

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