ZNF773

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.63677587
2indole-containing compound catabolic process (GO:0042436)4.09633114
3indolalkylamine catabolic process (GO:0046218)4.09633114
4tryptophan catabolic process (GO:0006569)4.09633114
5protein K11-linked deubiquitination (GO:0035871)4.02247411
6indolalkylamine metabolic process (GO:0006586)3.95083445
7kynurenine metabolic process (GO:0070189)3.93665649
8response to pheromone (GO:0019236)3.81487360
9neural tube formation (GO:0001841)3.80413028
10protein polyglutamylation (GO:0018095)3.60318455
11detection of light stimulus involved in visual perception (GO:0050908)3.59399870
12detection of light stimulus involved in sensory perception (GO:0050962)3.59399870
13tryptophan metabolic process (GO:0006568)3.58743395
14axoneme assembly (GO:0035082)3.57129682
15platelet dense granule organization (GO:0060155)3.53201361
16DNA deamination (GO:0045006)3.49493612
17L-fucose catabolic process (GO:0042355)3.44426830
18fucose catabolic process (GO:0019317)3.44426830
19L-fucose metabolic process (GO:0042354)3.44426830
20piRNA metabolic process (GO:0034587)3.41424021
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.40112502
22negative regulation of telomere maintenance (GO:0032205)3.37966855
23mannosylation (GO:0097502)3.34960751
24behavioral response to ethanol (GO:0048149)3.33216757
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22353482
26epithelial cilium movement (GO:0003351)3.14524017
27preassembly of GPI anchor in ER membrane (GO:0016254)3.13610324
28cilium morphogenesis (GO:0060271)3.11844200
29gamma-aminobutyric acid transport (GO:0015812)3.08977918
30indole-containing compound metabolic process (GO:0042430)3.08850402
31negative regulation of mast cell activation (GO:0033004)3.07454585
32signal peptide processing (GO:0006465)3.07141785
33photoreceptor cell maintenance (GO:0045494)2.99694509
34regulation of hippo signaling (GO:0035330)2.94773293
35retinal cone cell development (GO:0046549)2.92737755
36establishment of protein localization to Golgi (GO:0072600)2.92327194
37protein localization to cilium (GO:0061512)2.90810664
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90372831
39reflex (GO:0060004)2.90014538
40respiratory chain complex IV assembly (GO:0008535)2.88658780
41adaptation of signaling pathway (GO:0023058)2.88229986
42regulation of telomere maintenance (GO:0032204)2.87071929
43DNA methylation involved in gamete generation (GO:0043046)2.85513222
44amine catabolic process (GO:0009310)2.84422223
45cellular biogenic amine catabolic process (GO:0042402)2.84422223
46rRNA catabolic process (GO:0016075)2.84322955
47multicellular organism reproduction (GO:0032504)2.81472008
48regulation of cilium movement (GO:0003352)2.81008092
49negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80880863
50replication fork processing (GO:0031297)2.80372196
51pyrimidine nucleobase catabolic process (GO:0006208)2.79783104
52cilium organization (GO:0044782)2.78473896
53recombinational repair (GO:0000725)2.77912804
54nonmotile primary cilium assembly (GO:0035058)2.77581806
55regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75169009
56double-strand break repair via homologous recombination (GO:0000724)2.75102920
57positive regulation of oligodendrocyte differentiation (GO:0048714)2.74621806
58rhodopsin mediated signaling pathway (GO:0016056)2.72146119
59neuronal action potential (GO:0019228)2.71634567
60cilium assembly (GO:0042384)2.69610914
61regulation of meiosis I (GO:0060631)2.69559240
62cilium movement (GO:0003341)2.68581480
63oxidative demethylation (GO:0070989)2.67708246
64tachykinin receptor signaling pathway (GO:0007217)2.67095812
65cilium or flagellum-dependent cell motility (GO:0001539)2.67069968
66DNA double-strand break processing (GO:0000729)2.67066797
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66155519
68mitochondrial respiratory chain complex I assembly (GO:0032981)2.66155519
69NADH dehydrogenase complex assembly (GO:0010257)2.66155519
70anterograde synaptic vesicle transport (GO:0048490)2.65592405
71benzene-containing compound metabolic process (GO:0042537)2.65582454
72reciprocal DNA recombination (GO:0035825)2.65418579
73reciprocal meiotic recombination (GO:0007131)2.65418579
74male meiosis I (GO:0007141)2.65067747
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64999292
76proline transport (GO:0015824)2.62914827
77centriole replication (GO:0007099)2.62084846
78sulfation (GO:0051923)2.60594878
79protein complex biogenesis (GO:0070271)2.60034859
80photoreceptor cell development (GO:0042461)2.59581132
81histone H3-K9 methylation (GO:0051567)2.59196639
82serotonin metabolic process (GO:0042428)2.54581980
83negative regulation of translation, ncRNA-mediated (GO:0040033)2.54470080
84regulation of translation, ncRNA-mediated (GO:0045974)2.54470080
85negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54470080
86cytochrome complex assembly (GO:0017004)2.53413837
87embryonic epithelial tube formation (GO:0001838)2.50664932
88cornea development in camera-type eye (GO:0061303)2.48751055
89cellular response to sterol (GO:0036315)2.48072015
90regulation of collateral sprouting (GO:0048670)2.48058452
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47623262
92intraciliary transport (GO:0042073)2.47600102
93primary amino compound metabolic process (GO:1901160)2.47571614
94GPI anchor metabolic process (GO:0006505)2.46159633
95water-soluble vitamin biosynthetic process (GO:0042364)2.44090302
96transmission of nerve impulse (GO:0019226)2.44077880
97negative regulation of systemic arterial blood pressure (GO:0003085)2.43703781
98somite development (GO:0061053)2.43544425
99regulation of action potential (GO:0098900)2.43281580
100protein localization to Golgi apparatus (GO:0034067)2.43232235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.97097833
2GBX2_23144817_ChIP-Seq_PC3_Human3.27330174
3IGF1R_20145208_ChIP-Seq_DFB_Human3.13158707
4VDR_22108803_ChIP-Seq_LS180_Human2.96864457
5EZH2_22144423_ChIP-Seq_EOC_Human2.96792009
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66515529
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49705023
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46136439
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34521636
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.31727015
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28477582
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22980086
13EWS_26573619_Chip-Seq_HEK293_Human2.13418386
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11778784
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10770658
16FUS_26573619_Chip-Seq_HEK293_Human2.03629286
17P300_19829295_ChIP-Seq_ESCs_Human2.03086407
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.02403705
19TAF15_26573619_Chip-Seq_HEK293_Human2.02049006
20ER_23166858_ChIP-Seq_MCF-7_Human1.99267975
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.99169777
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98161408
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88799797
24IRF1_19129219_ChIP-ChIP_H3396_Human1.82299182
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71793141
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69526125
27CBP_20019798_ChIP-Seq_JUKART_Human1.67076339
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67076339
29STAT3_23295773_ChIP-Seq_U87_Human1.66593981
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62293091
31SMAD4_21799915_ChIP-Seq_A2780_Human1.59233351
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59160718
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55741776
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55458835
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.51850797
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50890547
37TCF4_23295773_ChIP-Seq_U87_Human1.48341080
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47791684
39BCAT_22108803_ChIP-Seq_LS180_Human1.47685365
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47497647
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47087107
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44708954
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44239618
44TP53_22573176_ChIP-Seq_HFKS_Human1.42813091
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.40104300
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39675010
47AR_25329375_ChIP-Seq_VCAP_Human1.39536029
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38448177
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.37401330
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.36830752
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35605073
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.31898733
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29942757
54MYC_18940864_ChIP-ChIP_HL60_Human1.29330307
55RUNX2_22187159_ChIP-Seq_PCA_Human1.27995590
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26126448
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25940612
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25940612
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23259920
60TCF4_22108803_ChIP-Seq_LS180_Human1.22709840
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.21983993
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21731757
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21596929
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.20668209
65NANOG_19829295_ChIP-Seq_ESCs_Human1.20306179
66SOX2_19829295_ChIP-Seq_ESCs_Human1.20306179
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20185280
68AR_21572438_ChIP-Seq_LNCaP_Human1.18556173
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.16805965
70REST_21632747_ChIP-Seq_MESCs_Mouse1.16177416
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.16037022
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16037022
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15779044
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14771667
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14744630
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14587422
77* VDR_23849224_ChIP-Seq_CD4+_Human1.14428195
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14017351
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12555314
80NCOR_22424771_ChIP-Seq_293T_Human1.12554457
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.11999477
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.11340485
83P53_22387025_ChIP-Seq_ESCs_Mouse1.09297503
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08714827
85ELK1_19687146_ChIP-ChIP_HELA_Human1.07984383
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.07215336
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.06728240
88CDX2_22108803_ChIP-Seq_LS180_Human1.05954834
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04815678
90RNF2_27304074_Chip-Seq_NSC_Mouse1.04287037
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03393153
92AR_20517297_ChIP-Seq_VCAP_Human1.02744800
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99568684
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.99442826
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99435728
96HOXB7_26014856_ChIP-Seq_BT474_Human0.99154722
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98652038
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97492157
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97221644
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.97079317

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.25737551
2MP0008877_abnormal_DNA_methylation2.83957346
3MP0002102_abnormal_ear_morphology2.82146001
4MP0003195_calcinosis2.79568731
5MP0000372_irregular_coat_pigmentation2.77452853
6MP0005551_abnormal_eye_electrophysiolog2.65884787
7MP0002837_dystrophic_cardiac_calcinosis2.47473722
8MP0006072_abnormal_retinal_apoptosis2.29980112
9MP0003136_yellow_coat_color2.28771939
10MP0005171_absent_coat_pigmentation2.26975004
11MP0005646_abnormal_pituitary_gland2.22607101
12MP0005253_abnormal_eye_physiology2.13049106
13MP0001968_abnormal_touch/_nociception2.09241794
14MP0002638_abnormal_pupillary_reflex2.07544729
15MP0001501_abnormal_sleep_pattern2.06554287
16MP0003646_muscle_fatigue2.00857218
17MP0003787_abnormal_imprinting1.97937670
18MP0009046_muscle_twitch1.94232415
19MP0006276_abnormal_autonomic_nervous1.86420529
20MP0006292_abnormal_olfactory_placode1.84782177
21MP0004142_abnormal_muscle_tone1.81118740
22MP0000631_abnormal_neuroendocrine_gland1.81042556
23MP0005645_abnormal_hypothalamus_physiol1.80335634
24MP0002095_abnormal_skin_pigmentation1.79430958
25MP0001984_abnormal_olfaction1.78911758
26MP0005174_abnormal_tail_pigmentation1.77743789
27MP0005075_abnormal_melanosome_morpholog1.76666746
28MP0002736_abnormal_nociception_after1.75957378
29MP0004147_increased_porphyrin_level1.68522292
30MP0004043_abnormal_pH_regulation1.67929585
31MP0009745_abnormal_behavioral_response1.66325757
32MP0004133_heterotaxia1.63823530
33MP0008058_abnormal_DNA_repair1.62125479
34MP0002938_white_spotting1.57208501
35MP0000427_abnormal_hair_cycle1.51417716
36MP0003880_abnormal_central_pattern1.51095722
37MP0008872_abnormal_physiological_respon1.47312299
38MP0002138_abnormal_hepatobiliary_system1.40350837
39MP0002272_abnormal_nervous_system1.40004455
40MP0000015_abnormal_ear_pigmentation1.36477066
41MP0001986_abnormal_taste_sensitivity1.35341583
42MP0001486_abnormal_startle_reflex1.35196589
43MP0002928_abnormal_bile_duct1.32057603
44MP0005377_hearing/vestibular/ear_phenot1.29972483
45MP0003878_abnormal_ear_physiology1.29972483
46MP0002653_abnormal_ependyma_morphology1.28980713
47MP0000371_diluted_coat_color1.25000881
48MP0002876_abnormal_thyroid_physiology1.22278852
49MP0002572_abnormal_emotion/affect_behav1.16995604
50MP0010386_abnormal_urinary_bladder1.16644051
51MP0002064_seizures1.16218048
52MP0008789_abnormal_olfactory_epithelium1.15306272
53MP0005389_reproductive_system_phenotype1.15264359
54MP0003011_delayed_dark_adaptation1.14762286
55MP0004885_abnormal_endolymph1.13984603
56MP0005379_endocrine/exocrine_gland_phen1.13705492
57MP0002735_abnormal_chemical_nociception1.13509642
58MP0004145_abnormal_muscle_electrophysio1.12595729
59MP0002160_abnormal_reproductive_system1.11919799
60MP0002557_abnormal_social/conspecific_i1.11533711
61MP0002067_abnormal_sensory_capabilities1.04573274
62MP0001485_abnormal_pinna_reflex1.04189402
63MP0004924_abnormal_behavior1.03998119
64MP0005386_behavior/neurological_phenoty1.03998119
65MP0003786_premature_aging1.02656232
66MP0001324_abnormal_eye_pigmentation1.01508261
67MP0005195_abnormal_posterior_eye0.99973935
68MP0001529_abnormal_vocalization0.99662120
69MP0001919_abnormal_reproductive_system0.99027392
70MP0005310_abnormal_salivary_gland0.97971827
71MP0002751_abnormal_autonomic_nervous0.96691363
72MP0008875_abnormal_xenobiotic_pharmacok0.96616446
73MP0003252_abnormal_bile_duct0.96377206
74MP0001970_abnormal_pain_threshold0.95304184
75MP0002234_abnormal_pharynx_morphology0.94419446
76MP0000383_abnormal_hair_follicle0.93791087
77MP0000778_abnormal_nervous_system0.93512634
78MP0003718_maternal_effect0.91078501
79MP0003698_abnormal_male_reproductive0.90801620
80MP0005084_abnormal_gallbladder_morpholo0.90793977
81MP0008995_early_reproductive_senescence0.90368875
82MP0002229_neurodegeneration0.89288774
83MP0004215_abnormal_myocardial_fiber0.88546326
84MP0003890_abnormal_embryonic-extraembry0.87394201
85MP0002733_abnormal_thermal_nociception0.86768862
86MP0002752_abnormal_somatic_nervous0.86537536
87MP0005408_hypopigmentation0.84975295
88MP0003635_abnormal_synaptic_transmissio0.83120166
89MP0002063_abnormal_learning/memory/cond0.80861552
90MP0005391_vision/eye_phenotype0.76576347
91MP0001929_abnormal_gametogenesis0.76448695
92MP0008057_abnormal_DNA_replication0.76347570
93MP0004742_abnormal_vestibular_system0.76163173
94MP0002184_abnormal_innervation0.76064167
95MP0000647_abnormal_sebaceous_gland0.75655956
96MP0000026_abnormal_inner_ear0.74851626
97MP0005394_taste/olfaction_phenotype0.74604441
98MP0005499_abnormal_olfactory_system0.74604441
99MP0001764_abnormal_homeostasis0.73397529
100MP0000538_abnormal_urinary_bladder0.72783594

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.64296365
2Congenital stationary night blindness (HP:0007642)4.36452383
3Pancreatic fibrosis (HP:0100732)4.34528319
4Abnormality of midbrain morphology (HP:0002418)4.01491948
5Molar tooth sign on MRI (HP:0002419)4.01491948
6True hermaphroditism (HP:0010459)3.94361571
7Nephronophthisis (HP:0000090)3.57510670
8Attenuation of retinal blood vessels (HP:0007843)3.39320661
9Medial flaring of the eyebrow (HP:0010747)3.37984026
10Gaze-evoked nystagmus (HP:0000640)3.36478719
11Abnormality of the renal medulla (HP:0100957)3.27933952
12Abnormality of the renal cortex (HP:0011035)3.20560671
13Bile duct proliferation (HP:0001408)3.09193003
14Abnormal biliary tract physiology (HP:0012439)3.09193003
15Abolished electroretinogram (ERG) (HP:0000550)3.08167766
16Hyperventilation (HP:0002883)3.05838664
17Chronic hepatic failure (HP:0100626)2.93991714
18Abnormal rod and cone electroretinograms (HP:0008323)2.90675574
19Genetic anticipation (HP:0003743)2.88439422
20Cystic liver disease (HP:0006706)2.85053861
21Gait imbalance (HP:0002141)2.83651014
22Congenital primary aphakia (HP:0007707)2.79461663
23Pendular nystagmus (HP:0012043)2.70971514
24Type II lissencephaly (HP:0007260)2.64642593
25Nephrogenic diabetes insipidus (HP:0009806)2.62841804
26Progressive cerebellar ataxia (HP:0002073)2.62509015
27Increased corneal curvature (HP:0100692)2.48034454
28Keratoconus (HP:0000563)2.48034454
29Absent speech (HP:0001344)2.39685593
30Chorioretinal atrophy (HP:0000533)2.38020967
31Renal cortical cysts (HP:0000803)2.37803428
32Tubular atrophy (HP:0000092)2.36796375
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.36588950
34Stomach cancer (HP:0012126)2.36317173
35Hypoplasia of the fovea (HP:0007750)2.35736714
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.35736714
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.35375005
38Congenital hepatic fibrosis (HP:0002612)2.34472882
39Febrile seizures (HP:0002373)2.30451597
40Abnormality of macular pigmentation (HP:0008002)2.28853456
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27778671
42Genital tract atresia (HP:0001827)2.25828280
43Inability to walk (HP:0002540)2.23812752
44Sclerocornea (HP:0000647)2.23777532
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22802804
46Congenital sensorineural hearing impairment (HP:0008527)2.21478263
47Vaginal atresia (HP:0000148)2.19242716
48Atonic seizures (HP:0010819)2.18661893
49Anencephaly (HP:0002323)2.17789592
50Abnormal drinking behavior (HP:0030082)2.16180013
51Polydipsia (HP:0001959)2.16180013
52Lissencephaly (HP:0001339)2.15543867
53Protruding tongue (HP:0010808)2.14034193
54Progressive inability to walk (HP:0002505)2.11798871
55Dialeptic seizures (HP:0011146)2.09480659
56Abnormality of the fovea (HP:0000493)2.06504290
57Colon cancer (HP:0003003)2.06421408
58Clumsiness (HP:0002312)2.06269287
59Postaxial foot polydactyly (HP:0001830)2.03310760
60Cerebellar dysplasia (HP:0007033)2.02508694
61Focal motor seizures (HP:0011153)2.02385640
62Poor coordination (HP:0002370)2.02099170
63Bony spicule pigmentary retinopathy (HP:0007737)2.02034276
64Thyroiditis (HP:0100646)2.00839042
65Male pseudohermaphroditism (HP:0000037)1.98266508
66Decreased central vision (HP:0007663)1.97386393
67Albinism (HP:0001022)1.96533153
68Thyroid-stimulating hormone excess (HP:0002925)1.96385899
69Methylmalonic acidemia (HP:0002912)1.93015680
70Broad-based gait (HP:0002136)1.92476467
71Occipital encephalocele (HP:0002085)1.91987324
72Focal seizures (HP:0007359)1.91631882
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91012627
74Abnormality of alanine metabolism (HP:0010916)1.91012627
75Hyperalaninemia (HP:0003348)1.91012627
76Severe visual impairment (HP:0001141)1.90082852
77Furrowed tongue (HP:0000221)1.89995743
78Retinitis pigmentosa (HP:0000510)1.89638915
79Intestinal atresia (HP:0011100)1.89267282
80Fair hair (HP:0002286)1.88621533
81Postaxial hand polydactyly (HP:0001162)1.87604438
82Abnormal glycosylation (HP:0012345)1.86976376
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86976376
84Abnormal protein N-linked glycosylation (HP:0012347)1.86976376
85Abnormal protein glycosylation (HP:0012346)1.86976376
86Astigmatism (HP:0000483)1.84905055
87Methylmalonic aciduria (HP:0012120)1.79531977
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.78984456
89Hypoplasia of the pons (HP:0012110)1.78614509
90Polyuria (HP:0000103)1.77900425
91Pachygyria (HP:0001302)1.77722296
92Small hand (HP:0200055)1.77415026
93Hypothermia (HP:0002045)1.76700035
94Abnormality of the pons (HP:0007361)1.76611641
95Abnormal ciliary motility (HP:0012262)1.75160936
96Generalized hypopigmentation of hair (HP:0011358)1.73666228
97Large for gestational age (HP:0001520)1.73181287
98Preaxial hand polydactyly (HP:0001177)1.71783494
99Absence seizures (HP:0002121)1.71699802
100Optic nerve hypoplasia (HP:0000609)1.71062756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.72066638
2PINK12.79346558
3WNK32.73483508
4NUAK12.71623135
5TAOK32.70452649
6ADRBK22.44041854
7BMPR1B2.43255573
8GRK12.05930959
9MAP4K22.05776577
10ZAK2.05395772
11TXK2.00910479
12ACVR1B1.81413189
13INSRR1.79081446
14CAMKK21.77767197
15MAP3K41.76540061
16CASK1.65803867
17MAPK131.62353166
18TNK21.57515037
19TRIM281.49138713
20AKT31.34115038
21MAP2K71.30791490
22CSNK1A1L1.28821467
23CSNK1G31.28640317
24OXSR11.26993520
25TLK11.25420828
26PAK31.25153982
27CSNK1G11.23611487
28BCR1.21335234
29CSNK1G21.21140644
30BCKDK1.20466515
31PIK3CA1.18338981
32MKNK21.17948751
33PLK21.00194689
34WNK40.99237402
35BRSK20.96686265
36CDK190.96549498
37ADRBK10.94734957
38EPHA30.94310479
39STK390.93467517
40MARK10.91649104
41NME10.86319171
42LATS10.85976406
43DYRK20.85915910
44MAP2K60.84897586
45DAPK20.82358824
46PRKCE0.80851609
47BRD40.77889155
48KIT0.75393049
49ERBB30.74661683
50IKBKB0.71186091
51PRKCG0.70581613
52MARK30.70196853
53STK38L0.69909163
54NTRK20.67681391
55TGFBR10.66981971
56CCNB10.65367366
57MAPKAPK30.63947400
58EPHA40.63791057
59CAMK10.63200221
60TEC0.62920332
61OBSCN0.62391763
62PHKG10.60943280
63PHKG20.60943280
64PKN10.59844583
65FLT30.59583958
66MKNK10.59445056
67PTK2B0.59354894
68FER0.57507561
69NTRK30.56818125
70SIK20.53547839
71FGFR20.53224351
72CAMK2A0.52988538
73PRKAA10.52376169
74CAMK1D0.51171581
75MAPKAPK50.50374219
76PRKCQ0.50226746
77MAP4K10.50020401
78CSNK1A10.49638846
79VRK10.48357569
80CAMK1G0.46030116
81SYK0.45768652
82CSNK1D0.44275645
83CAMK40.44170491
84TIE10.43621838
85RPS6KA50.42818589
86PIK3CG0.42483826
87CHUK0.42346003
88PRKACA0.40894497
89GRK70.40871163
90PLK40.39801157
91GRK50.39469125
92DYRK1A0.38320878
93ATR0.37205144
94MATK0.35063692
95TRPM70.34627271
96ITK0.34135601
97IKBKE0.32967106
98MAP3K50.31777435
99MAP3K70.31344014
100LCK0.30552258

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.20243477
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.86596743
3Nitrogen metabolism_Homo sapiens_hsa009102.39863279
4RNA polymerase_Homo sapiens_hsa030202.35208086
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30541800
6Linoleic acid metabolism_Homo sapiens_hsa005912.25254995
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23849028
8Nicotine addiction_Homo sapiens_hsa050332.22079260
9Butanoate metabolism_Homo sapiens_hsa006502.17199683
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14025360
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07631756
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02425051
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00023249
14Homologous recombination_Homo sapiens_hsa034401.99453245
15Fanconi anemia pathway_Homo sapiens_hsa034601.92525839
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90929310
17Selenocompound metabolism_Homo sapiens_hsa004501.86832136
18Protein export_Homo sapiens_hsa030601.74509317
19Tryptophan metabolism_Homo sapiens_hsa003801.73275440
20Ether lipid metabolism_Homo sapiens_hsa005651.73251140
21Caffeine metabolism_Homo sapiens_hsa002321.69989273
22Taste transduction_Homo sapiens_hsa047421.66986706
23Propanoate metabolism_Homo sapiens_hsa006401.66821604
24Basal transcription factors_Homo sapiens_hsa030221.65955561
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61237202
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57546300
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.56527833
28Regulation of autophagy_Homo sapiens_hsa041401.53698084
29RNA degradation_Homo sapiens_hsa030181.42998776
30Olfactory transduction_Homo sapiens_hsa047401.39024005
31Morphine addiction_Homo sapiens_hsa050321.36877021
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.31545794
33Circadian rhythm_Homo sapiens_hsa047101.31514735
34Peroxisome_Homo sapiens_hsa041461.27674124
35Oxidative phosphorylation_Homo sapiens_hsa001901.23392239
36ABC transporters_Homo sapiens_hsa020101.21731210
37Non-homologous end-joining_Homo sapiens_hsa034501.21146692
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13254970
39Primary immunodeficiency_Homo sapiens_hsa053401.06166603
40GABAergic synapse_Homo sapiens_hsa047271.05809947
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02919620
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02613868
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.01771794
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.00190804
45Chemical carcinogenesis_Homo sapiens_hsa052040.94471716
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89917088
47Serotonergic synapse_Homo sapiens_hsa047260.88491222
48Retinol metabolism_Homo sapiens_hsa008300.86734903
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85547009
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85051757
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83323122
52Calcium signaling pathway_Homo sapiens_hsa040200.83149897
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82912629
54Insulin secretion_Homo sapiens_hsa049110.81539895
55Circadian entrainment_Homo sapiens_hsa047130.80199193
56Ovarian steroidogenesis_Homo sapiens_hsa049130.79968683
57Glutamatergic synapse_Homo sapiens_hsa047240.79963286
58beta-Alanine metabolism_Homo sapiens_hsa004100.79570448
59Purine metabolism_Homo sapiens_hsa002300.79260124
60Parkinsons disease_Homo sapiens_hsa050120.78050871
61One carbon pool by folate_Homo sapiens_hsa006700.74886987
62Dorso-ventral axis formation_Homo sapiens_hsa043200.71300947
63Collecting duct acid secretion_Homo sapiens_hsa049660.70777808
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68672157
65Arachidonic acid metabolism_Homo sapiens_hsa005900.66222071
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.65950098
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64973891
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64518822
69Glycerolipid metabolism_Homo sapiens_hsa005610.63356912
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60331519
71Huntingtons disease_Homo sapiens_hsa050160.58276166
72Salivary secretion_Homo sapiens_hsa049700.56789365
73Metabolic pathways_Homo sapiens_hsa011000.55679063
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54490971
75Pyrimidine metabolism_Homo sapiens_hsa002400.48982712
76Asthma_Homo sapiens_hsa053100.48831109
77Lysine degradation_Homo sapiens_hsa003100.46647788
78Cardiac muscle contraction_Homo sapiens_hsa042600.45572595
79Dopaminergic synapse_Homo sapiens_hsa047280.41346602
80Cholinergic synapse_Homo sapiens_hsa047250.40501602
81Histidine metabolism_Homo sapiens_hsa003400.39453283
82Oxytocin signaling pathway_Homo sapiens_hsa049210.39153284
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37637956
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37239482
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36327037
86Sphingolipid metabolism_Homo sapiens_hsa006000.35912095
87Alzheimers disease_Homo sapiens_hsa050100.35286292
88Mineral absorption_Homo sapiens_hsa049780.35030129
89Type I diabetes mellitus_Homo sapiens_hsa049400.34202567
90Nucleotide excision repair_Homo sapiens_hsa034200.32335270
91Fatty acid metabolism_Homo sapiens_hsa012120.32236663
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30484058
93Proteasome_Homo sapiens_hsa030500.30425191
94Sulfur metabolism_Homo sapiens_hsa009200.29460472
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.28910718
96Steroid biosynthesis_Homo sapiens_hsa001000.28406229
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28088168
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.27759306
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27601487
100Long-term depression_Homo sapiens_hsa047300.27204267

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