ZNF771

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)4.79565229
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.65345678
3behavioral response to nicotine (GO:0035095)4.42692219
4protein complex biogenesis (GO:0070271)4.32525828
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27347832
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.25403563
7NADH dehydrogenase complex assembly (GO:0010257)4.25403563
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.25403563
9mitochondrial respiratory chain complex assembly (GO:0033108)4.14931210
10ATP synthesis coupled proton transport (GO:0015986)4.12294656
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.12294656
12DNA replication checkpoint (GO:0000076)4.08971704
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.04215027
14transcription elongation from RNA polymerase III promoter (GO:0006385)3.96533020
15termination of RNA polymerase III transcription (GO:0006386)3.96533020
16pseudouridine synthesis (GO:0001522)3.94309215
17regulation of mitochondrial translation (GO:0070129)3.82816933
18peptidyl-histidine modification (GO:0018202)3.75982571
19protein-cofactor linkage (GO:0018065)3.70679618
20base-excision repair, AP site formation (GO:0006285)3.68535834
21respiratory electron transport chain (GO:0022904)3.62967109
22electron transport chain (GO:0022900)3.60311151
23water-soluble vitamin biosynthetic process (GO:0042364)3.57782199
24respiratory chain complex IV assembly (GO:0008535)3.57226686
25maturation of SSU-rRNA (GO:0030490)3.52531301
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.31933838
27rRNA modification (GO:0000154)3.27978495
28cytochrome complex assembly (GO:0017004)3.27617261
29ribosomal small subunit biogenesis (GO:0042274)3.26892053
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22578518
31cullin deneddylation (GO:0010388)3.22024503
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19049805
33intracellular protein transmembrane import (GO:0044743)3.18713325
34GTP biosynthetic process (GO:0006183)3.15409188
35proteasome assembly (GO:0043248)3.07060503
36chromatin remodeling at centromere (GO:0031055)3.06011846
37DNA strand renaturation (GO:0000733)3.04298319
38spliceosomal snRNP assembly (GO:0000387)3.04253742
39protein neddylation (GO:0045116)3.03077088
40establishment of protein localization to mitochondrion (GO:0072655)2.99903856
41protein deneddylation (GO:0000338)2.98336508
42protein targeting to mitochondrion (GO:0006626)2.98077056
43tRNA modification (GO:0006400)2.93919068
44cellular component biogenesis (GO:0044085)2.93742265
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93420373
46replication fork processing (GO:0031297)2.93402346
47rRNA processing (GO:0006364)2.91212463
48preassembly of GPI anchor in ER membrane (GO:0016254)2.87734190
49tRNA processing (GO:0008033)2.87643410
50UTP biosynthetic process (GO:0006228)2.87038225
51metallo-sulfur cluster assembly (GO:0031163)2.85452879
52iron-sulfur cluster assembly (GO:0016226)2.85452879
53ribosomal small subunit assembly (GO:0000028)2.85348941
54CENP-A containing nucleosome assembly (GO:0034080)2.85168694
55rRNA metabolic process (GO:0016072)2.81381500
56DNA deamination (GO:0045006)2.80412417
57pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80014111
58protein localization to mitochondrion (GO:0070585)2.77515800
59pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.76654115
60CTP biosynthetic process (GO:0006241)2.71654349
61CTP metabolic process (GO:0046036)2.71654349
62protein K6-linked ubiquitination (GO:0085020)2.70102887
63UTP metabolic process (GO:0046051)2.66515136
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65671635
65purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64716193
66L-serine metabolic process (GO:0006563)2.64347357
67meiotic chromosome segregation (GO:0045132)2.64186960
68intracellular protein transmembrane transport (GO:0065002)2.63492508
69rRNA methylation (GO:0031167)2.62353797
70ncRNA processing (GO:0034470)2.56548190
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55887373
72DNA damage response, detection of DNA damage (GO:0042769)2.55733823
73pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.53595034
74ribonucleoprotein complex biogenesis (GO:0022613)2.53291059
75tRNA metabolic process (GO:0006399)2.52306603
76viral transcription (GO:0019083)2.51815006
77translational termination (GO:0006415)2.51687336
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51594327
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51594327
80ribonucleoside triphosphate biosynthetic process (GO:0009201)2.51131823
81ATP biosynthetic process (GO:0006754)2.49965039
82ncRNA metabolic process (GO:0034660)2.48117268
83protein transmembrane transport (GO:0071806)2.47784646
84maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46831477
85serine family amino acid catabolic process (GO:0009071)2.46069614
86transcription-coupled nucleotide-excision repair (GO:0006283)2.45196745
87hydrogen ion transmembrane transport (GO:1902600)2.45145448
88guanosine-containing compound biosynthetic process (GO:1901070)2.44768655
89DNA replication-dependent nucleosome assembly (GO:0006335)2.42708990
90DNA replication-dependent nucleosome organization (GO:0034723)2.42708990
91ribosome biogenesis (GO:0042254)2.41441293
92mannosylation (GO:0097502)2.41286267
93nonmotile primary cilium assembly (GO:0035058)2.41198944
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.40658464
95kinetochore assembly (GO:0051382)2.40354852
96pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.40232926
97translation (GO:0006412)2.38188079
98DNA strand elongation involved in DNA replication (GO:0006271)2.38005611
99transcription from RNA polymerase I promoter (GO:0006360)2.37047371
100transcription from RNA polymerase III promoter (GO:0006383)2.36352668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16376085
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.15247198
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.84226303
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.52745789
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.46717413
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.39514626
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.25104530
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82366764
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.81720912
10XRN2_22483619_ChIP-Seq_HELA_Human2.68206758
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63166180
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61184336
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54791789
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33924537
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29594156
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26681372
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23847970
18GABP_19822575_ChIP-Seq_HepG2_Human2.23293402
19E2F7_22180533_ChIP-Seq_HELA_Human2.16657495
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09020008
21VDR_23849224_ChIP-Seq_CD4+_Human2.07465230
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06367148
23TTF2_22483619_ChIP-Seq_HELA_Human2.03577794
24ZNF274_21170338_ChIP-Seq_K562_Hela2.01583536
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.99328768
26DCP1A_22483619_ChIP-Seq_HELA_Human1.98132962
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97961638
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.95964988
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91540745
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91266659
31EZH2_22144423_ChIP-Seq_EOC_Human1.85597701
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85263717
33FOXP3_21729870_ChIP-Seq_TREG_Human1.84016039
34MYC_18940864_ChIP-ChIP_HL60_Human1.77241141
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.72099542
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61613418
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56297423
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54778639
39KDM5A_27292631_Chip-Seq_BREAST_Human1.49671732
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49579378
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46769712
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.44737786
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42943792
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42413129
45ELK1_19687146_ChIP-ChIP_HELA_Human1.40753645
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.40363332
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38641909
48* FOXP1_21924763_ChIP-Seq_HESCs_Human1.37824900
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35448432
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35252609
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29299032
52EWS_26573619_Chip-Seq_HEK293_Human1.25817738
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25527331
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25188366
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24644634
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.20556301
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20236373
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19845227
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19337016
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17979736
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.16621147
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13671138
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13134588
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.12362653
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.12309788
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10678128
67ERA_21632823_ChIP-Seq_H3396_Human1.09369041
68TP53_22573176_ChIP-Seq_HFKS_Human1.09160465
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.08666586
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03090909
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02665255
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01896536
73P68_20966046_ChIP-Seq_HELA_Human0.99724297
74SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99694290
75CIITA_25753668_ChIP-Seq_RAJI_Human0.97444307
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96923976
77VDR_22108803_ChIP-Seq_LS180_Human0.95615530
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95433222
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95132028
80CTCF_20526341_ChIP-Seq_ESCs_Human0.94817304
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94703711
82PHF8_20622854_ChIP-Seq_HELA_Human0.94509308
83E2F1_20622854_ChIP-Seq_HELA_Human0.91926809
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91404701
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91355306
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90696745
87JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90653907
88BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90431820
89REST_18959480_ChIP-ChIP_MESCs_Mouse0.89281047
90MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89044016
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88223648
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87570559
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.87010634
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86817026
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86479539
96* CTCF_27219007_Chip-Seq_Bcells_Human0.86048912
97RNF2_27304074_Chip-Seq_NSC_Mouse0.85970096
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.85055966
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83654519
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82363065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.26606610
2MP0003136_yellow_coat_color3.47269405
3MP0002736_abnormal_nociception_after2.63838460
4MP0001968_abnormal_touch/_nociception2.55273899
5MP0001529_abnormal_vocalization2.48180387
6MP0005423_abnormal_somatic_nervous2.43985117
7MP0003693_abnormal_embryo_hatching2.28755650
8MP0002653_abnormal_ependyma_morphology2.15940869
9MP0008058_abnormal_DNA_repair2.10086723
10MP0010094_abnormal_chromosome_stability2.06145157
11MP0003880_abnormal_central_pattern2.05730128
12MP0001188_hyperpigmentation2.00516483
13MP0006292_abnormal_olfactory_placode1.95626022
14MP0001986_abnormal_taste_sensitivity1.94232920
15MP0005171_absent_coat_pigmentation1.92606479
16MP0002160_abnormal_reproductive_system1.78054203
17MP0008877_abnormal_DNA_methylation1.76305185
18MP0000049_abnormal_middle_ear1.75549041
19MP0006072_abnormal_retinal_apoptosis1.73238005
20MP0009745_abnormal_behavioral_response1.72462661
21MP0003111_abnormal_nucleus_morphology1.68835715
22MP0005551_abnormal_eye_electrophysiolog1.57069003
23MP0000631_abnormal_neuroendocrine_gland1.56761042
24MP0009379_abnormal_foot_pigmentation1.53549963
25MP0009046_muscle_twitch1.47480679
26MP0008789_abnormal_olfactory_epithelium1.45824453
27MP0001905_abnormal_dopamine_level1.44394916
28MP0002249_abnormal_larynx_morphology1.42758904
29MP0002735_abnormal_chemical_nociception1.41049301
30MP0004859_abnormal_synaptic_plasticity1.37504240
31MP0004147_increased_porphyrin_level1.34697431
32MP0004133_heterotaxia1.34644933
33MP0006036_abnormal_mitochondrial_physio1.34486026
34MP0003786_premature_aging1.34319322
35MP0002064_seizures1.34032014
36MP0005174_abnormal_tail_pigmentation1.32876226
37MP0003635_abnormal_synaptic_transmissio1.31205338
38MP0008932_abnormal_embryonic_tissue1.31175248
39MP0002638_abnormal_pupillary_reflex1.30606202
40MP0004885_abnormal_endolymph1.29784914
41MP0002272_abnormal_nervous_system1.28780391
42MP0004142_abnormal_muscle_tone1.28497521
43MP0003718_maternal_effect1.26676094
44MP0005646_abnormal_pituitary_gland1.25134811
45MP0005499_abnormal_olfactory_system1.20382413
46MP0005394_taste/olfaction_phenotype1.20382413
47MP0008875_abnormal_xenobiotic_pharmacok1.19943441
48MP0002751_abnormal_autonomic_nervous1.19714838
49MP0002938_white_spotting1.18236832
50MP0003077_abnormal_cell_cycle1.17934975
51MP0006276_abnormal_autonomic_nervous1.16814195
52MP0003937_abnormal_limbs/digits/tail_de1.13916706
53MP0005253_abnormal_eye_physiology1.12943250
54MP0006035_abnormal_mitochondrial_morpho1.12826719
55MP0001970_abnormal_pain_threshold1.12507627
56MP0002063_abnormal_learning/memory/cond1.12014708
57MP0002572_abnormal_emotion/affect_behav1.11925997
58MP0002102_abnormal_ear_morphology1.09952017
59MP0000778_abnormal_nervous_system1.09166719
60MP0008872_abnormal_physiological_respon1.09163825
61MP0003123_paternal_imprinting1.07272044
62MP0005389_reproductive_system_phenotype1.06558831
63MP0008007_abnormal_cellular_replicative1.06101929
64MP0004957_abnormal_blastocyst_morpholog1.05152144
65MP0001486_abnormal_startle_reflex1.04550356
66MP0003011_delayed_dark_adaptation1.01707797
67MP0001293_anophthalmia0.99731753
68MP0001502_abnormal_circadian_rhythm0.98884164
69MP0002234_abnormal_pharynx_morphology0.98645206
70MP0001984_abnormal_olfaction0.97292278
71MP0010030_abnormal_orbit_morphology0.96447508
72MP0000026_abnormal_inner_ear0.96383629
73MP0002277_abnormal_respiratory_mucosa0.96178670
74MP0003283_abnormal_digestive_organ0.95679488
75MP0000955_abnormal_spinal_cord0.95198651
76MP0003119_abnormal_digestive_system0.94362987
77MP0005386_behavior/neurological_phenoty0.93519011
78MP0004924_abnormal_behavior0.93519011
79MP0003938_abnormal_ear_development0.93407186
80MP0002282_abnormal_trachea_morphology0.93110216
81MP0002733_abnormal_thermal_nociception0.92556048
82MP0002557_abnormal_social/conspecific_i0.92118497
83MP0003137_abnormal_impulse_conducting0.91974017
84MP0002184_abnormal_innervation0.89045799
85MP0002210_abnormal_sex_determination0.87463785
86MP0009250_abnormal_appendicular_skeleto0.87244587
87MP0004043_abnormal_pH_regulation0.86961989
88MP0002752_abnormal_somatic_nervous0.86649278
89MP0005084_abnormal_gallbladder_morpholo0.84749429
90MP0001919_abnormal_reproductive_system0.84392234
91MP0004742_abnormal_vestibular_system0.84089377
92MP0004145_abnormal_muscle_electrophysio0.84005092
93MP0001764_abnormal_homeostasis0.83505025
94MP0002067_abnormal_sensory_capabilities0.83342436
95MP0001346_abnormal_lacrimal_gland0.83276453
96MP0003186_abnormal_redox_activity0.82544858
97MP0002876_abnormal_thyroid_physiology0.82487705
98MP0002734_abnormal_mechanical_nocicepti0.82038447
99MP0003121_genomic_imprinting0.81460728
100MP0002837_dystrophic_cardiac_calcinosis0.79956501

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.07231567
2Mitochondrial inheritance (HP:0001427)3.93074190
3Abnormal mitochondria in muscle tissue (HP:0008316)3.82281678
4Increased hepatocellular lipid droplets (HP:0006565)3.69703966
5Increased CSF lactate (HP:0002490)3.60638692
6Acute encephalopathy (HP:0006846)3.59173834
7Lipid accumulation in hepatocytes (HP:0006561)3.55378725
8Renal Fanconi syndrome (HP:0001994)3.45276464
9Hepatocellular necrosis (HP:0001404)3.42059740
10Progressive macrocephaly (HP:0004481)3.22392914
11Testicular atrophy (HP:0000029)3.15084675
12Hepatic necrosis (HP:0002605)3.10398230
13Birth length less than 3rd percentile (HP:0003561)3.09760008
14Abnormal number of erythroid precursors (HP:0012131)3.07130669
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92192517
16Congenital stationary night blindness (HP:0007642)2.91068430
17Increased intramyocellular lipid droplets (HP:0012240)2.90690815
18Rib fusion (HP:0000902)2.90271801
19Pancreatic cysts (HP:0001737)2.74446677
20Abnormality of cells of the erythroid lineage (HP:0012130)2.70804444
21Abnormality of alanine metabolism (HP:0010916)2.68732425
22Hyperalaninemia (HP:0003348)2.68732425
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68732425
24Patellar aplasia (HP:0006443)2.68669460
25Aplasia/Hypoplasia of the patella (HP:0006498)2.66479324
26Pendular nystagmus (HP:0012043)2.64005117
27Increased serum lactate (HP:0002151)2.63904074
28True hermaphroditism (HP:0010459)2.62505883
29Abnormality of midbrain morphology (HP:0002418)2.59503648
30Molar tooth sign on MRI (HP:0002419)2.59503648
31Pancreatic fibrosis (HP:0100732)2.57305632
32Increased muscle lipid content (HP:0009058)2.52589170
33Optic disc pallor (HP:0000543)2.51026743
34Lactic acidosis (HP:0003128)2.47041425
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43919590
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43919590
37Methylmalonic aciduria (HP:0012120)2.38788927
38Rectal fistula (HP:0100590)2.35701683
39Rectovaginal fistula (HP:0000143)2.35701683
40Colon cancer (HP:0003003)2.34376395
41Myokymia (HP:0002411)2.31572760
42Cerebral edema (HP:0002181)2.31072884
43Reticulocytopenia (HP:0001896)2.26680489
44Sclerocornea (HP:0000647)2.21801450
45Type II lissencephaly (HP:0007260)2.20568350
463-Methylglutaconic aciduria (HP:0003535)2.19943300
47Absent thumb (HP:0009777)2.19749692
48Exertional dyspnea (HP:0002875)2.19469408
49Hypoplasia of the pons (HP:0012110)2.18097431
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15329276
51Medial flaring of the eyebrow (HP:0010747)2.13823192
52Nephronophthisis (HP:0000090)2.13253465
53Abnormality of renal resorption (HP:0011038)2.11186018
54Progressive microcephaly (HP:0000253)2.08393718
55Exercise intolerance (HP:0003546)2.08315130
56Respiratory difficulties (HP:0002880)2.07532199
57Anencephaly (HP:0002323)2.07062972
58Abnormality of the pons (HP:0007361)2.04640512
59Gait imbalance (HP:0002141)2.04129339
60Respiratory failure (HP:0002878)2.02400870
61Concave nail (HP:0001598)2.02311107
62Microretrognathia (HP:0000308)2.00386872
63Glycosuria (HP:0003076)2.00208524
64Abnormality of urine glucose concentration (HP:0011016)2.00208524
65Attenuation of retinal blood vessels (HP:0007843)2.00029019
66Leukodystrophy (HP:0002415)1.97642726
67Vaginal fistula (HP:0004320)1.94892316
68Methylmalonic acidemia (HP:0002912)1.91128445
69Severe muscular hypotonia (HP:0006829)1.86148321
70Intestinal fistula (HP:0100819)1.85420297
71Cerebral hypomyelination (HP:0006808)1.83193449
72Congenital primary aphakia (HP:0007707)1.82969080
73Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82716403
74Abnormal drinking behavior (HP:0030082)1.82517253
75Polydipsia (HP:0001959)1.82517253
76Broad distal phalanx of finger (HP:0009836)1.78688932
77Chorioretinal atrophy (HP:0000533)1.74950378
78Macrocytic anemia (HP:0001972)1.74887813
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.74023067
80Dyschromatopsia (HP:0007641)1.73755351
81Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72802903
82Opisthotonus (HP:0002179)1.71215942
83Occipital encephalocele (HP:0002085)1.70154857
84Absent radius (HP:0003974)1.68843872
85Meckel diverticulum (HP:0002245)1.68273279
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67548792
87Hypoplasia of the radius (HP:0002984)1.66831955
88Polyuria (HP:0000103)1.66635351
89Breast hypoplasia (HP:0003187)1.66597613
90Congenital, generalized hypertrichosis (HP:0004540)1.66096793
91Triphalangeal thumb (HP:0001199)1.65812671
92Horseshoe kidney (HP:0000085)1.65577654
93Abnormality of the ileum (HP:0001549)1.65069869
94Absent forearm bone (HP:0003953)1.65037687
95Aplasia involving forearm bones (HP:0009822)1.65037687
96Lethargy (HP:0001254)1.64996436
97Retinal dysplasia (HP:0007973)1.63461232
98Short thumb (HP:0009778)1.61487174
99Preaxial hand polydactyly (HP:0001177)1.61230247
100Abnormality of the renal medulla (HP:0100957)1.60414297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.52686765
2STK163.62523270
3ZAK3.34102724
4VRK23.21129900
5BUB13.07925214
6VRK12.45888812
7MAPK152.42106835
8NME12.27428314
9MAP4K22.11943002
10WNK42.08610231
11CDC71.94348519
12ADRBK21.92108826
13GRK11.89425389
14DYRK21.78200758
15SRPK11.67060623
16NUAK11.67055259
17MAP2K71.63356635
18BCKDK1.59125303
19PINK11.54389065
20MUSK1.52582432
21BMPR1B1.52025021
22NME21.51972201
23WNK31.44724149
24MAPK131.42286008
25CSNK1G31.40796719
26MARK11.40379958
27MAP3K41.39025718
28TAF11.33198189
29FRK1.32362973
30WEE11.28359120
31CSNK1G11.25446112
32PDK21.24116637
33CHEK21.23090419
34CSNK1A1L1.21426185
35PHKG11.20502107
36PHKG21.20502107
37CSNK1G21.17271718
38ATR1.09170126
39PLK31.09004426
40AURKA1.08545233
41PLK11.06079638
42CASK1.05431014
43CCNB11.04503576
44CDK81.04418908
45PRKCG0.99326906
46DYRK30.97950491
47PLK40.89335632
48PNCK0.87734079
49TRIM280.87656227
50NTRK20.85181700
51RPS6KA50.83296648
52INSRR0.82910096
53TSSK60.79780627
54LIMK10.77703739
55PIM20.77411220
56EPHA40.73336503
57MINK10.72487438
58PKN10.70417305
59PRKCI0.70133652
60PAK60.68959906
61OXSR10.68865158
62PBK0.67837291
63NEK10.67345803
64TNIK0.67117306
65PRKD30.66002464
66ABL20.64762246
67IRAK20.62587014
68MAPKAPK50.62324266
69ADRBK10.61436059
70UHMK10.58900440
71AURKB0.58314544
72TESK20.58006432
73TAOK30.56631860
74PLK20.53799773
75BRSK10.53556246
76NEK20.50580653
77NTRK30.49486755
78MAP2K40.49301904
79TIE10.48442608
80CSNK1A10.48301881
81TTK0.48147594
82CSNK2A10.47719556
83BCR0.46918857
84ATM0.46373644
85DAPK20.45913969
86DAPK10.45790565
87EIF2AK20.44067612
88CDK11A0.42619559
89CDK150.42409633
90CDK180.40181695
91CSNK1E0.39781851
92CDK140.39382814
93CSNK2A20.39359741
94CDK30.38606099
95DAPK30.38552745
96GRK50.37525933
97CSNK1D0.37204178
98STK390.37003171
99AKT20.36294222
100CAMK10.35113417

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.58446115
2RNA polymerase_Homo sapiens_hsa030203.26475594
3Ribosome_Homo sapiens_hsa030103.13648702
4Parkinsons disease_Homo sapiens_hsa050123.09685103
5Homologous recombination_Homo sapiens_hsa034402.83321676
6Sulfur relay system_Homo sapiens_hsa041222.82648795
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68586214
8DNA replication_Homo sapiens_hsa030302.55483910
9Proteasome_Homo sapiens_hsa030502.31807742
10Huntingtons disease_Homo sapiens_hsa050162.30524277
11Base excision repair_Homo sapiens_hsa034102.27224825
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09916422
13Alzheimers disease_Homo sapiens_hsa050102.06061150
14Fanconi anemia pathway_Homo sapiens_hsa034602.03209372
15Pyrimidine metabolism_Homo sapiens_hsa002402.02990138
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98507859
17Basal transcription factors_Homo sapiens_hsa030221.95909561
18Mismatch repair_Homo sapiens_hsa034301.90528088
19One carbon pool by folate_Homo sapiens_hsa006701.81656637
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81364860
21Nucleotide excision repair_Homo sapiens_hsa034201.77225935
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74964841
23Cardiac muscle contraction_Homo sapiens_hsa042601.71050523
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66508238
25Protein export_Homo sapiens_hsa030601.64662311
26Nicotine addiction_Homo sapiens_hsa050331.59633271
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49481642
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46973068
29Spliceosome_Homo sapiens_hsa030401.44351262
30RNA degradation_Homo sapiens_hsa030181.33383794
31Non-homologous end-joining_Homo sapiens_hsa034501.29581325
32Purine metabolism_Homo sapiens_hsa002301.27441460
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.27396360
34Selenocompound metabolism_Homo sapiens_hsa004501.26255835
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23346813
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14444685
37Pyruvate metabolism_Homo sapiens_hsa006201.13415219
38RNA transport_Homo sapiens_hsa030131.12752721
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08657962
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07833385
41Phototransduction_Homo sapiens_hsa047441.07222028
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05107520
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04555279
44Butanoate metabolism_Homo sapiens_hsa006500.94203713
45Propanoate metabolism_Homo sapiens_hsa006400.93401463
46Vitamin B6 metabolism_Homo sapiens_hsa007500.88133768
47Metabolic pathways_Homo sapiens_hsa011000.84980599
48Cell cycle_Homo sapiens_hsa041100.84496074
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81567849
50Arginine and proline metabolism_Homo sapiens_hsa003300.74763411
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73463598
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72176176
53Steroid biosynthesis_Homo sapiens_hsa001000.69661897
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.67804126
55Peroxisome_Homo sapiens_hsa041460.67100438
56Tryptophan metabolism_Homo sapiens_hsa003800.65504795
57Alcoholism_Homo sapiens_hsa050340.64805104
58Morphine addiction_Homo sapiens_hsa050320.62052828
59Taste transduction_Homo sapiens_hsa047420.61791816
60beta-Alanine metabolism_Homo sapiens_hsa004100.61762558
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.60830563
62Nitrogen metabolism_Homo sapiens_hsa009100.59898368
63Fatty acid elongation_Homo sapiens_hsa000620.59892623
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57369147
65GABAergic synapse_Homo sapiens_hsa047270.56930056
66Folate biosynthesis_Homo sapiens_hsa007900.55888309
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55801904
68Linoleic acid metabolism_Homo sapiens_hsa005910.54319495
69Basal cell carcinoma_Homo sapiens_hsa052170.53053847
70Collecting duct acid secretion_Homo sapiens_hsa049660.50261231
71Synaptic vesicle cycle_Homo sapiens_hsa047210.49208287
72Hedgehog signaling pathway_Homo sapiens_hsa043400.47028718
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45775810
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44949220
75Systemic lupus erythematosus_Homo sapiens_hsa053220.43619787
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41224858
77Biosynthesis of amino acids_Homo sapiens_hsa012300.40944987
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39536905
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39153178
80Vitamin digestion and absorption_Homo sapiens_hsa049770.38780197
81Cocaine addiction_Homo sapiens_hsa050300.33546157
82Sulfur metabolism_Homo sapiens_hsa009200.33112554
83Chemical carcinogenesis_Homo sapiens_hsa052040.31598526
84Glutamatergic synapse_Homo sapiens_hsa047240.30697999
85Olfactory transduction_Homo sapiens_hsa047400.30318404
86mRNA surveillance pathway_Homo sapiens_hsa030150.30274895
87Insulin secretion_Homo sapiens_hsa049110.30047458
88Lysine degradation_Homo sapiens_hsa003100.29940048
89Fatty acid degradation_Homo sapiens_hsa000710.29464664
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29301254
91Hippo signaling pathway_Homo sapiens_hsa043900.29067214
92Ether lipid metabolism_Homo sapiens_hsa005650.28520284
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.27318122
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27075800
95Circadian entrainment_Homo sapiens_hsa047130.27030922
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26937333
97Oocyte meiosis_Homo sapiens_hsa041140.26578969
98Cholinergic synapse_Homo sapiens_hsa047250.24788197
99Calcium signaling pathway_Homo sapiens_hsa040200.24181694
100Fatty acid biosynthesis_Homo sapiens_hsa000610.24164582

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