ZNF764

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.66168595
2negative regulation of transcription regulatory region DNA binding (GO:2000678)4.30586443
3positive regulation by host of viral transcription (GO:0043923)4.25073177
4base-excision repair, AP site formation (GO:0006285)3.60908640
5tRNA modification (GO:0006400)3.49954421
6CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.48858347
7activated T cell proliferation (GO:0050798)3.46586424
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.40671247
9NADH dehydrogenase complex assembly (GO:0010257)3.40671247
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40671247
11head development (GO:0060322)3.36473512
12preassembly of GPI anchor in ER membrane (GO:0016254)3.35601050
13negative regulation of telomere maintenance (GO:0032205)3.30283006
14positive regulation of T cell apoptotic process (GO:0070234)3.25347811
15protein insertion into membrane (GO:0051205)3.18177700
16positive regulation of CREB transcription factor activity (GO:0032793)3.16225652
17pyrimidine nucleobase catabolic process (GO:0006208)3.10754241
18protein-cofactor linkage (GO:0018065)3.08988756
19negative regulation of cAMP-mediated signaling (GO:0043951)3.06387966
20neuronal stem cell maintenance (GO:0097150)3.02538696
21ubiquinone biosynthetic process (GO:0006744)3.02510136
22L-fucose catabolic process (GO:0042355)2.98754759
23fucose catabolic process (GO:0019317)2.98754759
24L-fucose metabolic process (GO:0042354)2.98754759
25meiotic chromosome segregation (GO:0045132)2.98461979
26ubiquinone metabolic process (GO:0006743)2.97456671
27maturation of SSU-rRNA (GO:0030490)2.96797559
28response to pheromone (GO:0019236)2.96222196
29cell migration in hindbrain (GO:0021535)2.89468868
30positive regulation of protein homooligomerization (GO:0032464)2.89062520
31neuron fate specification (GO:0048665)2.87446686
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85283297
33protein complex biogenesis (GO:0070271)2.83810554
34neuron fate determination (GO:0048664)2.83625279
35positive regulation of lymphocyte apoptotic process (GO:0070230)2.83102066
36piRNA metabolic process (GO:0034587)2.82889814
37modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.82889737
38adaptation of signaling pathway (GO:0023058)2.81910653
39somite development (GO:0061053)2.81154150
40ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.81025562
41histone H3-K4 trimethylation (GO:0080182)2.80227454
42modulation by host of symbiont transcription (GO:0052472)2.79849651
43modulation by host of viral transcription (GO:0043921)2.79849651
44negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.79351217
45respiratory chain complex IV assembly (GO:0008535)2.70559826
46regulation of mesenchymal cell apoptotic process (GO:2001053)2.69864061
47histone H3-K9 methylation (GO:0051567)2.69740288
48interferon-gamma production (GO:0032609)2.68183087
49rRNA catabolic process (GO:0016075)2.68031089
50positive regulation of mitochondrial fission (GO:0090141)2.66814315
51regulation of transcription regulatory region DNA binding (GO:2000677)2.65449750
52mitochondrial respiratory chain complex assembly (GO:0033108)2.65045721
53pyrimidine nucleotide catabolic process (GO:0006244)2.64296913
54negative regulation by host of viral transcription (GO:0043922)2.64102270
55histone H3-K9 modification (GO:0061647)2.61858388
56endoderm formation (GO:0001706)2.59701315
57positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.58222761
58cellular response to ATP (GO:0071318)2.57749090
59dentate gyrus development (GO:0021542)2.56938954
60establishment of mitochondrion localization (GO:0051654)2.56650934
61viral protein processing (GO:0019082)2.52063750
62regulation of chromatin binding (GO:0035561)2.50678075
63negative regulation of T cell differentiation in thymus (GO:0033085)2.50265702
64positive regulation of histone deacetylation (GO:0031065)2.48357250
65tRNA processing (GO:0008033)2.48256499
66DNA demethylation (GO:0080111)2.47628645
67neuronal action potential (GO:0019228)2.47280269
68granulocyte differentiation (GO:0030851)2.46368461
69synaptic transmission, cholinergic (GO:0007271)2.46142845
70cytochrome complex assembly (GO:0017004)2.46102067
71negative regulation of DNA-templated transcription, elongation (GO:0032785)2.42707258
72metallo-sulfur cluster assembly (GO:0031163)2.42154018
73iron-sulfur cluster assembly (GO:0016226)2.42154018
74pseudouridine synthesis (GO:0001522)2.41578843
75cell differentiation in spinal cord (GO:0021515)2.41233819
76cellular response to nicotine (GO:0071316)2.41170553
77snRNA transcription (GO:0009301)2.40149112
78epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39044566
79T cell lineage commitment (GO:0002360)2.38998767
80cellular response to exogenous dsRNA (GO:0071360)2.38955516
81positive regulation of Notch signaling pathway (GO:0045747)2.36677987
82gamma-aminobutyric acid transport (GO:0015812)2.36297852
83DNA deamination (GO:0045006)2.36077596
84C-terminal protein lipidation (GO:0006501)2.35838869
85Peyers patch development (GO:0048541)2.34987871
86mucosal-associated lymphoid tissue development (GO:0048537)2.34987871
87neuron cell-cell adhesion (GO:0007158)2.34111930
88protein polyglutamylation (GO:0018095)2.34043812
89negative regulation of DNA binding (GO:0043392)2.30968819
90regulation of glycogen (starch) synthase activity (GO:2000465)2.30860761
91post-embryonic morphogenesis (GO:0009886)2.30617137
92tolerance induction (GO:0002507)2.28928939
93neurotransmitter metabolic process (GO:0042133)2.27970331
94negative regulation of cell aging (GO:0090344)2.27316004
95histone H4-K16 acetylation (GO:0043984)2.26419422
96negative regulation of mast cell activation (GO:0033004)2.26399721
97nephron tubule morphogenesis (GO:0072078)2.25679435
98nephron epithelium morphogenesis (GO:0072088)2.25679435
99peptidyl-histidine modification (GO:0018202)2.25542852
100DNA methylation involved in gamete generation (GO:0043046)2.25329524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97665006
2NOTCH1_21737748_ChIP-Seq_TLL_Human3.65164821
3ZNF274_21170338_ChIP-Seq_K562_Hela3.28565069
4TP63_19390658_ChIP-ChIP_HaCaT_Human2.97438136
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62363726
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58669027
7* ETS1_20019798_ChIP-Seq_JURKAT_Human2.50402667
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48762129
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.29340191
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.17831880
11VDR_21846776_ChIP-Seq_THP-1_Human2.12857645
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.07824637
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.03606348
14GABP_19822575_ChIP-Seq_HepG2_Human1.93667802
15* CIITA_25753668_ChIP-Seq_RAJI_Human1.93433462
16VDR_23849224_ChIP-Seq_CD4+_Human1.91940505
17YY1_21170310_ChIP-Seq_MESCs_Mouse1.85812987
18* XRN2_22483619_ChIP-Seq_HELA_Human1.80688508
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79265107
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77330258
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76497463
22PHF8_20622854_ChIP-Seq_HELA_Human1.75174316
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73773587
24KDM5A_27292631_Chip-Seq_BREAST_Human1.72741411
25MYC_22102868_ChIP-Seq_BL_Human1.72724315
26* P68_20966046_ChIP-Seq_HELA_Human1.72160685
27FOXP3_21729870_ChIP-Seq_TREG_Human1.71013194
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70261475
29IGF1R_20145208_ChIP-Seq_DFB_Human1.69436243
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68119576
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67065999
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66804265
33IRF1_19129219_ChIP-ChIP_H3396_Human1.64889382
34* BCL6_27268052_Chip-Seq_Bcells_Human1.64434601
35ERA_21632823_ChIP-Seq_H3396_Human1.63596121
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63007028
37MYC_18940864_ChIP-ChIP_HL60_Human1.59497745
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55460296
39* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.53928427
40* E2F1_20622854_ChIP-Seq_HELA_Human1.51273810
41* ELF1_20517297_ChIP-Seq_JURKAT_Human1.49331379
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45079637
43SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.44137758
44* BCOR_27268052_Chip-Seq_Bcells_Human1.43822564
45MAF_26560356_Chip-Seq_TH2_Human1.43581157
46FOXP1_21924763_ChIP-Seq_HESCs_Human1.42129318
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39357955
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38627431
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.37345328
50YY1_22570637_ChIP-Seq_MALME-3M_Human1.33185125
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.32380126
52* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31534108
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.31136344
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.30472680
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29760243
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29684147
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.26660513
58TTF2_22483619_ChIP-Seq_HELA_Human1.26178566
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25916940
60REST_21632747_ChIP-Seq_MESCs_Mouse1.23509397
61RAC3_21632823_ChIP-Seq_H3396_Human1.22801122
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22196294
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20969025
64RNF2_27304074_Chip-Seq_NSC_Mouse1.20425552
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18714477
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17061989
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16021967
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13664719
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.12978990
70TP53_22573176_ChIP-Seq_HFKS_Human1.12828484
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12505859
72CTCF_27219007_Chip-Seq_Bcells_Human1.12092713
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10738809
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09438616
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09113486
76TAF2_19829295_ChIP-Seq_ESCs_Human1.08837290
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06406017
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06105069
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05796954
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05096116
81OCT4_20526341_ChIP-Seq_ESCs_Human1.04595439
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04268674
83* NANOG_20526341_ChIP-Seq_ESCs_Human1.04033459
84* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03996448
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03978839
86* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03888312
87RARB_24833708_ChIP-Seq_LIVER_Mouse1.03111194
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01895349
89TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99986587
90CTCF_26484167_Chip-Seq_Bcells_Mouse0.99418173
91SA1_27219007_Chip-Seq_ERYTHROID_Human0.99314517
92P300_27268052_Chip-Seq_Bcells_Human0.98278802
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97932681
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97184656
95DCP1A_22483619_ChIP-Seq_HELA_Human0.96923051
96* CTCF_20526341_ChIP-Seq_ESCs_Human0.96454679
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.96289742
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95563747
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95336437
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95150416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology3.19864042
2MP0002653_abnormal_ependyma_morphology2.77489149
3MP0006292_abnormal_olfactory_placode2.77086697
4MP0003136_yellow_coat_color2.64905722
5MP0003787_abnormal_imprinting2.26412809
6MP0004133_heterotaxia2.26356296
7MP0005379_endocrine/exocrine_gland_phen2.12313252
8MP0008877_abnormal_DNA_methylation2.12116914
9MP0003646_muscle_fatigue2.07391264
10MP0005423_abnormal_somatic_nervous2.06334251
11MP0008995_early_reproductive_senescence2.05851942
12MP0002277_abnormal_respiratory_mucosa2.03167322
13MP0001986_abnormal_taste_sensitivity1.98239174
14MP0005645_abnormal_hypothalamus_physiol1.92735973
15MP0002234_abnormal_pharynx_morphology1.89677995
16MP0000049_abnormal_middle_ear1.84572640
17MP0008961_abnormal_basal_metabolism1.83663333
18MP0002837_dystrophic_cardiac_calcinosis1.75093185
19MP0004142_abnormal_muscle_tone1.73289068
20MP0001919_abnormal_reproductive_system1.70845169
21MP0001873_stomach_inflammation1.67971600
22MP0002132_abnormal_respiratory_system1.65984592
23MP0003122_maternal_imprinting1.64325680
24MP0008789_abnormal_olfactory_epithelium1.57013292
25MP0000778_abnormal_nervous_system1.56543406
26MP0001346_abnormal_lacrimal_gland1.51969496
27MP0004742_abnormal_vestibular_system1.48845841
28MP0000631_abnormal_neuroendocrine_gland1.46675929
29MP0002249_abnormal_larynx_morphology1.43878509
30MP0001968_abnormal_touch/_nociception1.42187797
31MP0002160_abnormal_reproductive_system1.37808310
32MP0008872_abnormal_physiological_respon1.33804583
33MP0005394_taste/olfaction_phenotype1.29862379
34MP0005499_abnormal_olfactory_system1.29862379
35MP0000372_irregular_coat_pigmentation1.29001523
36MP0003121_genomic_imprinting1.28934527
37MP0005389_reproductive_system_phenotype1.26815918
38MP0003693_abnormal_embryo_hatching1.25852581
39MP0002102_abnormal_ear_morphology1.22652455
40MP0003890_abnormal_embryonic-extraembry1.21005441
41MP0002822_catalepsy1.20599793
42MP0002735_abnormal_chemical_nociception1.18019174
43MP0004381_abnormal_hair_follicle1.17673780
44MP0000015_abnormal_ear_pigmentation1.12656397
45MP0001529_abnormal_vocalization1.11475281
46MP0002210_abnormal_sex_determination1.11319176
47MP0001502_abnormal_circadian_rhythm1.05735088
48MP0005075_abnormal_melanosome_morpholog1.04302434
49MP0001905_abnormal_dopamine_level1.03574966
50MP0003763_abnormal_thymus_physiology1.02179676
51MP0001270_distended_abdomen1.00471819
52MP0005387_immune_system_phenotype0.99859184
53MP0001790_abnormal_immune_system0.99859184
54MP0003119_abnormal_digestive_system0.99847281
55MP0001188_hyperpigmentation0.99059445
56MP0001286_abnormal_eye_development0.98297209
57MP0005671_abnormal_response_to0.98118525
58MP0001293_anophthalmia0.97356751
59MP0009745_abnormal_behavioral_response0.97216008
60MP0002557_abnormal_social/conspecific_i0.96988415
61MP0008058_abnormal_DNA_repair0.95946540
62MP0005195_abnormal_posterior_eye0.93817291
63MP0000955_abnormal_spinal_cord0.92695211
64MP0001764_abnormal_homeostasis0.92615190
65MP0000470_abnormal_stomach_morphology0.92575965
66MP0000613_abnormal_salivary_gland0.92308478
67MP0001800_abnormal_humoral_immune0.92069191
68MP0000026_abnormal_inner_ear0.89240165
69MP0003861_abnormal_nervous_system0.88423713
70MP0002693_abnormal_pancreas_physiology0.88139405
71MP0005174_abnormal_tail_pigmentation0.87538166
72MP0005551_abnormal_eye_electrophysiolog0.86436024
73MP0004043_abnormal_pH_regulation0.85472654
74MP0003938_abnormal_ear_development0.85330188
75MP0002095_abnormal_skin_pigmentation0.84939326
76MP0008875_abnormal_xenobiotic_pharmacok0.83537663
77MP0000685_abnormal_immune_system0.83502154
78MP0001663_abnormal_digestive_system0.82752832
79MP0002928_abnormal_bile_duct0.82063820
80MP0009333_abnormal_splenocyte_physiolog0.81337039
81MP0004885_abnormal_endolymph0.80072244
82MP0005083_abnormal_biliary_tract0.79997661
83MP0003880_abnormal_central_pattern0.79682808
84MP0005448_abnormal_energy_balance0.78612133
85MP0002752_abnormal_somatic_nervous0.78103102
86MP0003698_abnormal_male_reproductive0.77508232
87MP0002067_abnormal_sensory_capabilities0.77469678
88MP0002152_abnormal_brain_morphology0.77313656
89MP0001929_abnormal_gametogenesis0.76533858
90MP0001944_abnormal_pancreas_morphology0.76415272
91MP0002736_abnormal_nociception_after0.75562799
92MP0003942_abnormal_urinary_system0.73240887
93MP0009278_abnormal_bone_marrow0.72517614
94MP0002733_abnormal_thermal_nociception0.72348302
95MP0001145_abnormal_male_reproductive0.71960083
96MP0010030_abnormal_orbit_morphology0.71709685
97MP0005220_abnormal_exocrine_pancreas0.70678946
98MP0002572_abnormal_emotion/affect_behav0.69895296
99MP0002063_abnormal_learning/memory/cond0.69586675
100MP0002138_abnormal_hepatobiliary_system0.69335243

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)3.67968460
2Molar tooth sign on MRI (HP:0002419)3.67968460
3Type II lissencephaly (HP:0007260)3.66704513
4Pancreatic cysts (HP:0001737)3.60197073
5Concave nail (HP:0001598)3.51186667
6Pancreatic fibrosis (HP:0100732)3.27101163
7True hermaphroditism (HP:0010459)3.09326914
8Nephronophthisis (HP:0000090)2.96779994
9Lissencephaly (HP:0001339)2.88087719
10Severe muscular hypotonia (HP:0006829)2.73102719
11Abnormality of the pons (HP:0007361)2.71922438
12Oligodactyly (hands) (HP:0001180)2.71460323
13Cerebellar dysplasia (HP:0007033)2.70427453
14Abnormality of the renal cortex (HP:0011035)2.64735794
15Patellar aplasia (HP:0006443)2.63138132
16Abnormal number of erythroid precursors (HP:0012131)2.62682200
17Anencephaly (HP:0002323)2.58660810
18Aplasia/Hypoplasia of the patella (HP:0006498)2.49865416
19Abnormality of the renal medulla (HP:0100957)2.47509210
20Sclerocornea (HP:0000647)2.46960036
21Hypoplasia of the pons (HP:0012110)2.46930741
22Abnormal pancreas size (HP:0012094)2.45956705
23Pendular nystagmus (HP:0012043)2.44980289
24Congenital stationary night blindness (HP:0007642)2.44608955
25Severe combined immunodeficiency (HP:0004430)2.43132350
26Abnormality of cells of the erythroid lineage (HP:0012130)2.42637852
27Birth length less than 3rd percentile (HP:0003561)2.34069001
28Panhypogammaglobulinemia (HP:0003139)2.33255381
29Pachygyria (HP:0001302)2.32076112
30Anophthalmia (HP:0000528)2.28545130
31Chronic hepatic failure (HP:0100626)2.26763400
32Medial flaring of the eyebrow (HP:0010747)2.22245657
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20832667
34Hyperventilation (HP:0002883)2.20466090
35Double outlet right ventricle (HP:0001719)2.20257260
36Congenital malformation of the right heart (HP:0011723)2.20257260
37Large for gestational age (HP:0001520)2.18427964
38Cystic liver disease (HP:0006706)2.15995629
39Neoplasm of the adrenal cortex (HP:0100641)2.10915145
40Rib fusion (HP:0000902)2.10692881
41Inability to walk (HP:0002540)2.08753746
42Retinal dysplasia (HP:0007973)2.07194050
43Attenuation of retinal blood vessels (HP:0007843)2.06584493
44Abnormality of DNA repair (HP:0003254)2.06178535
45Tubular atrophy (HP:0000092)2.04545224
46Hip dysplasia (HP:0001385)2.01927511
47Optic nerve coloboma (HP:0000588)2.00482535
48Abnormal delayed hypersensitivity skin test (HP:0002963)1.99262596
49Oligodactyly (HP:0012165)1.98712368
50Mitochondrial inheritance (HP:0001427)1.97358509
51Horseshoe kidney (HP:0000085)1.95531818
52Nephrogenic diabetes insipidus (HP:0009806)1.95403530
53Progressive inability to walk (HP:0002505)1.95365045
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95092921
55Mesangial abnormality (HP:0001966)1.91593126
56Reticulocytopenia (HP:0001896)1.89126606
57Abnormal rod and cone electroretinograms (HP:0008323)1.89031941
58Hepatocellular necrosis (HP:0001404)1.88320011
59Congenital hepatic fibrosis (HP:0002612)1.87069278
60Aplasia/Hypoplasia of the spleen (HP:0010451)1.86080178
61Abnormality of the renal collecting system (HP:0004742)1.85997482
623-Methylglutaconic aciduria (HP:0003535)1.85673694
63Abnormality of B cell number (HP:0010975)1.84984881
64Progressive microcephaly (HP:0000253)1.84626570
65Intellectual disability, severe (HP:0010864)1.84551526
66Bilateral microphthalmos (HP:0007633)1.83910790
67Protruding tongue (HP:0010808)1.82633228
68Increased CSF lactate (HP:0002490)1.80598716
69Renal cortical cysts (HP:0000803)1.79360960
70Abnormality of alanine metabolism (HP:0010916)1.78099052
71Hyperalaninemia (HP:0003348)1.78099052
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78099052
73Down-sloping shoulders (HP:0200021)1.73315917
74Lipid accumulation in hepatocytes (HP:0006561)1.72410254
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71838629
76Recurrent cutaneous fungal infections (HP:0011370)1.71497688
77Chronic mucocutaneous candidiasis (HP:0002728)1.71497688
78Hepatic necrosis (HP:0002605)1.70908215
79Rectal prolapse (HP:0002035)1.70090154
80Optic disc pallor (HP:0000543)1.69207562
8111 pairs of ribs (HP:0000878)1.68988758
82Broad-based gait (HP:0002136)1.68882062
83Duplicated collecting system (HP:0000081)1.68874234
84Microretrognathia (HP:0000308)1.68830961
85Gait imbalance (HP:0002141)1.68478588
86Occipital encephalocele (HP:0002085)1.67716304
87Truncus arteriosus (HP:0001660)1.67116102
88B lymphocytopenia (HP:0010976)1.66904393
89Hypoplasia of the uterus (HP:0000013)1.66689228
90Deep palmar crease (HP:0006191)1.66007536
91Increased serum lactate (HP:0002151)1.64180615
92Combined immunodeficiency (HP:0005387)1.63399165
93Abnormal biliary tract physiology (HP:0012439)1.62937541
94Bile duct proliferation (HP:0001408)1.62937541
95Renal dysplasia (HP:0000110)1.62347585
96Polydipsia (HP:0001959)1.61420344
97Abnormal drinking behavior (HP:0030082)1.61420344
98Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61311613
99Hypoplasia of the brainstem (HP:0002365)1.61311613
100Acute lymphatic leukemia (HP:0006721)1.61091819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.38949322
2SIK22.86716107
3WNK42.67261444
4TLK12.41858149
5STK162.29529653
6MAP4K22.25456842
7MAPK132.19680829
8ADRBK22.10803635
9TRIM282.08460230
10MAP3K41.93997745
11MAP3K111.89393570
12PRKD31.85881669
13TXK1.85408164
14MAP4K11.82093723
15DYRK21.80949277
16TRIB31.76714152
17MAP2K71.76033525
18ZAK1.72739905
19NUAK11.71751334
20TAOK31.70929067
21SIK31.62974967
22BMPR1B1.62255680
23WNK31.61274105
24SIK11.54709880
25VRK21.52991262
26CAMKK21.41714919
27NTRK21.37328821
28EEF2K1.28250481
29CASK1.27427145
30PRKD21.22435359
31HIPK21.19762323
32INSRR1.19214068
33IRAK41.15677240
34MARK21.14063307
35TAF11.12594563
36PINK11.10745532
37PRKCI1.07541951
38MAPK151.06183635
39TNK21.00795560
40CHUK0.99630565
41CAMK40.98726175
42LMTK20.98379170
43STK110.94692652
44MAPKAPK50.94274054
45PNCK0.92773772
46DYRK1B0.91891791
47DYRK30.91859326
48GRK10.91619247
49MAP2K40.90936678
50MARK10.88980720
51TYRO30.87338998
52EPHA30.85187631
53CHEK20.82422378
54PRKCQ0.80994105
55MAP3K70.80892735
56FRK0.79920217
57IKBKB0.79779144
58SMG10.79104537
59ATR0.75721109
60AURKA0.73707734
61RPS6KA50.73101365
62PRKAA10.72467756
63VRK10.72438078
64PRKCZ0.71547546
65CSNK1G30.71308532
66TESK20.70098837
67MAPKAPK30.66527534
68MAPK110.66396548
69GRK60.66286003
70IKBKE0.64012857
71CSNK1A1L0.63417181
72MAP2K60.61609357
73CAMKK10.61165880
74CSNK1G20.59827208
75CDK70.58880846
76MARK30.56399040
77SYK0.52507122
78CDK190.51977473
79MAP2K20.50433933
80IRAK10.50237842
81RPS6KA60.49907251
82PRKAA20.49434809
83ITK0.49015971
84MAPK120.46489224
85CDK40.44579082
86MAP3K100.43954771
87PRKCG0.42969947
88PRKCH0.41806230
89BCR0.40450214
90CDK80.40337676
91LYN0.39989889
92BTK0.39877322
93PIM10.39002545
94DAPK20.38535495
95PASK0.36312400
96TAOK10.36111327
97BRSK20.34321339
98EPHB20.33536590
99NME10.29270412
100CAMK1D0.28476473

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.88430019
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.73332904
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.39620014
4Primary immunodeficiency_Homo sapiens_hsa053402.90172272
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.62728234
6Basal transcription factors_Homo sapiens_hsa030222.39855406
7Oxidative phosphorylation_Homo sapiens_hsa001902.30128960
8Ribosome_Homo sapiens_hsa030102.22897025
9RNA polymerase_Homo sapiens_hsa030202.12666422
10Parkinsons disease_Homo sapiens_hsa050122.01463198
11Fanconi anemia pathway_Homo sapiens_hsa034601.93169439
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87575326
13Selenocompound metabolism_Homo sapiens_hsa004501.83648626
14Linoleic acid metabolism_Homo sapiens_hsa005911.83183028
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82583898
16Base excision repair_Homo sapiens_hsa034101.75773966
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73770433
18Homologous recombination_Homo sapiens_hsa034401.67457946
19Huntingtons disease_Homo sapiens_hsa050161.49307879
20Phototransduction_Homo sapiens_hsa047441.48824361
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44430332
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40867802
23Cardiac muscle contraction_Homo sapiens_hsa042601.39957606
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38290557
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35657711
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.34558632
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33016775
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.30362657
29Steroid biosynthesis_Homo sapiens_hsa001001.28345263
30Regulation of autophagy_Homo sapiens_hsa041401.28301043
31Nicotine addiction_Homo sapiens_hsa050331.26778392
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25574986
33Basal cell carcinoma_Homo sapiens_hsa052171.24884286
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10962713
35Notch signaling pathway_Homo sapiens_hsa043301.06801224
36RNA degradation_Homo sapiens_hsa030181.04074575
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00306407
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96686736
39Ether lipid metabolism_Homo sapiens_hsa005650.91784069
40Spliceosome_Homo sapiens_hsa030400.90949038
41T cell receptor signaling pathway_Homo sapiens_hsa046600.88966514
42Alzheimers disease_Homo sapiens_hsa050100.85325561
43Pyrimidine metabolism_Homo sapiens_hsa002400.80730774
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77559797
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76431124
46Hedgehog signaling pathway_Homo sapiens_hsa043400.75801916
47ABC transporters_Homo sapiens_hsa020100.74678383
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70970393
49Cocaine addiction_Homo sapiens_hsa050300.69212891
50Morphine addiction_Homo sapiens_hsa050320.68225608
51Butanoate metabolism_Homo sapiens_hsa006500.65842501
52RNA transport_Homo sapiens_hsa030130.65025221
53Nucleotide excision repair_Homo sapiens_hsa034200.64730861
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.60443467
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60017624
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.59453490
57mTOR signaling pathway_Homo sapiens_hsa041500.55341301
58B cell receptor signaling pathway_Homo sapiens_hsa046620.55189175
59Caffeine metabolism_Homo sapiens_hsa002320.54505879
60Tryptophan metabolism_Homo sapiens_hsa003800.54214322
61FoxO signaling pathway_Homo sapiens_hsa040680.53674367
62Epstein-Barr virus infection_Homo sapiens_hsa051690.52961448
63Type II diabetes mellitus_Homo sapiens_hsa049300.52906594
64Protein export_Homo sapiens_hsa030600.51392189
65Insulin resistance_Homo sapiens_hsa049310.51112394
66p53 signaling pathway_Homo sapiens_hsa041150.50801913
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50476789
68mRNA surveillance pathway_Homo sapiens_hsa030150.50117749
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47850081
70Glycerolipid metabolism_Homo sapiens_hsa005610.47284835
71Hepatitis B_Homo sapiens_hsa051610.46762008
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45487474
73Alcoholism_Homo sapiens_hsa050340.44368499
74Peroxisome_Homo sapiens_hsa041460.44333451
75Herpes simplex infection_Homo sapiens_hsa051680.42856220
76Graft-versus-host disease_Homo sapiens_hsa053320.42404803
77Colorectal cancer_Homo sapiens_hsa052100.41844108
78MAPK signaling pathway_Homo sapiens_hsa040100.41806582
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41509233
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40817972
81Collecting duct acid secretion_Homo sapiens_hsa049660.40209083
82Axon guidance_Homo sapiens_hsa043600.40071694
83VEGF signaling pathway_Homo sapiens_hsa043700.39202764
84Metabolic pathways_Homo sapiens_hsa011000.39000724
85Lysine degradation_Homo sapiens_hsa003100.38425471
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.37614738
87Acute myeloid leukemia_Homo sapiens_hsa052210.37160987
88Non-small cell lung cancer_Homo sapiens_hsa052230.36127785
89Allograft rejection_Homo sapiens_hsa053300.35043641
90Viral carcinogenesis_Homo sapiens_hsa052030.34223959
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33113381
92Asthma_Homo sapiens_hsa053100.33047652
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.33004329
94Choline metabolism in cancer_Homo sapiens_hsa052310.32913450
95Purine metabolism_Homo sapiens_hsa002300.31608230
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30517451
97Melanoma_Homo sapiens_hsa052180.28970581
98Dopaminergic synapse_Homo sapiens_hsa047280.28463934
99Autoimmune thyroid disease_Homo sapiens_hsa053200.27110399
100Olfactory transduction_Homo sapiens_hsa047400.26623015

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