ZNF749

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.34722523
2establishment of integrated proviral latency (GO:0075713)4.31282976
3DNA strand elongation (GO:0022616)4.21438713
4regulation of helicase activity (GO:0051095)4.02172151
5telomere maintenance via semi-conservative replication (GO:0032201)4.00833467
6transcription elongation from RNA polymerase III promoter (GO:0006385)3.90240557
7termination of RNA polymerase III transcription (GO:0006386)3.90240557
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84897815
9proteasome assembly (GO:0043248)3.84342103
10CENP-A containing nucleosome assembly (GO:0034080)3.78689197
11chromatin remodeling at centromere (GO:0031055)3.71860942
12spliceosomal snRNP assembly (GO:0000387)3.63317541
13cullin deneddylation (GO:0010388)3.62613045
14nucleotide-excision repair, DNA gap filling (GO:0006297)3.50574129
15pseudouridine synthesis (GO:0001522)3.49971400
16DNA replication-dependent nucleosome assembly (GO:0006335)3.48953868
17DNA replication-dependent nucleosome organization (GO:0034723)3.48953868
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46692513
19regulation of mitotic spindle checkpoint (GO:1903504)3.46692513
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44422694
21regulation of mitochondrial translation (GO:0070129)3.42624934
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40497675
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40076618
24establishment of viral latency (GO:0019043)3.39076964
25telomere maintenance via recombination (GO:0000722)3.36901859
26protein deneddylation (GO:0000338)3.36478571
27ribosomal large subunit biogenesis (GO:0042273)3.36125575
28DNA replication checkpoint (GO:0000076)3.34467179
29ribosome assembly (GO:0042255)3.33267644
30maturation of 5.8S rRNA (GO:0000460)3.31256334
31histone mRNA metabolic process (GO:0008334)3.30331769
32DNA damage response, detection of DNA damage (GO:0042769)3.29718704
33regulation of translational fidelity (GO:0006450)3.28433637
34nuclear pore organization (GO:0006999)3.28194375
35purine nucleobase biosynthetic process (GO:0009113)3.27029305
36ribosomal small subunit assembly (GO:0000028)3.25950068
37nucleobase biosynthetic process (GO:0046112)3.25694020
38ATP synthesis coupled proton transport (GO:0015986)3.25204639
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25204639
40DNA replication-independent nucleosome organization (GO:0034724)3.24550135
41DNA replication-independent nucleosome assembly (GO:0006336)3.24550135
42base-excision repair (GO:0006284)3.23655463
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23624089
44transcription-coupled nucleotide-excision repair (GO:0006283)3.20960694
45mitotic recombination (GO:0006312)3.20526566
46rRNA modification (GO:0000154)3.20054276
47DNA catabolic process, exonucleolytic (GO:0000738)3.18982362
48telomere maintenance via telomere lengthening (GO:0010833)3.17640748
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17600744
50base-excision repair, AP site formation (GO:0006285)3.16489451
51maturation of SSU-rRNA (GO:0030490)3.15428133
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13441428
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13441428
54mitochondrial respiratory chain complex assembly (GO:0033108)3.13137470
55negative regulation of ligase activity (GO:0051352)3.11478045
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11478045
57histone exchange (GO:0043486)3.11340363
58respiratory chain complex IV assembly (GO:0008535)3.10465169
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10425894
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10425894
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10425894
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09786197
63amino acid activation (GO:0043038)3.08089788
64tRNA aminoacylation (GO:0043039)3.08089788
65IMP biosynthetic process (GO:0006188)3.07698670
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07605805
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07605805
68tRNA aminoacylation for protein translation (GO:0006418)3.06994118
69protein complex biogenesis (GO:0070271)3.06597495
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06319028
71DNA ligation (GO:0006266)3.04879292
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.04772916
73NADH dehydrogenase complex assembly (GO:0010257)3.04772916
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04772916
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.04228251
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04228251
77viral mRNA export from host cell nucleus (GO:0046784)3.02144474
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.01628103
79protein K6-linked ubiquitination (GO:0085020)3.01148949
80rRNA processing (GO:0006364)2.99002868
81protein localization to kinetochore (GO:0034501)2.98610003
82DNA replication initiation (GO:0006270)2.97012825
83transcription from mitochondrial promoter (GO:0006390)2.96942141
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92743607
85mitotic metaphase plate congression (GO:0007080)2.92375291
86nuclear pore complex assembly (GO:0051292)2.91675715
87mitochondrial RNA metabolic process (GO:0000959)2.88868456
88DNA unwinding involved in DNA replication (GO:0006268)2.88835260
89non-recombinational repair (GO:0000726)2.88106290
90double-strand break repair via nonhomologous end joining (GO:0006303)2.88106290
91rRNA metabolic process (GO:0016072)2.88035688
92respiratory electron transport chain (GO:0022904)2.87914512
93translation (GO:0006412)2.84093160
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84010447
95mismatch repair (GO:0006298)2.83730744
96electron transport chain (GO:0022900)2.81457090
977-methylguanosine mRNA capping (GO:0006370)2.81425421
98establishment of protein localization to mitochondrial membrane (GO:0090151)2.81155062
99tRNA metabolic process (GO:0006399)2.79829736
100kinetochore organization (GO:0051383)2.79656323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.92044430
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.73474230
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.09875514
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.00899505
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.92699507
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77607445
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.46328884
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35392426
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.24460812
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98409321
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91313872
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.90563807
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86863797
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85438366
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84032418
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82976326
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76685226
18VDR_23849224_ChIP-Seq_CD4+_Human2.74303212
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73386540
20ELK1_19687146_ChIP-ChIP_HELA_Human2.67393639
21FOXP3_21729870_ChIP-Seq_TREG_Human2.53040388
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42293789
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41979693
24DCP1A_22483619_ChIP-Seq_HELA_Human2.39707202
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33588887
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33158311
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27949318
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26879684
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23218025
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17175090
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.11514828
32TTF2_22483619_ChIP-Seq_HELA_Human2.11502738
33GABP_19822575_ChIP-Seq_HepG2_Human2.11205309
34XRN2_22483619_ChIP-Seq_HELA_Human2.10593080
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.08166596
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04928052
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99669511
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95683195
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94577045
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.91701348
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.91266219
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86877899
43MYC_18940864_ChIP-ChIP_HL60_Human1.83811939
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80210920
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75732147
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74166243
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73818373
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72649295
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71695593
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67648873
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62665175
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54495543
53AR_21909140_ChIP-Seq_LNCAP_Human1.49545805
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47241363
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.44669623
56KDM5A_27292631_Chip-Seq_BREAST_Human1.43736678
57CIITA_25753668_ChIP-Seq_RAJI_Human1.31798690
58ZNF274_21170338_ChIP-Seq_K562_Hela1.30278089
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28737653
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27349052
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25345841
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.25143979
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22333776
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20267374
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.18730370
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16865719
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14498685
68EWS_26573619_Chip-Seq_HEK293_Human1.10727079
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08327584
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06871316
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06231605
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.03414055
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01679136
74POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97706192
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97261229
76TFEB_21752829_ChIP-Seq_HELA_Human0.97057028
77NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97006152
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96486242
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94906267
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92162968
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.92123575
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91495186
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91065186
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89888764
85SALL1_21062744_ChIP-ChIP_HESCs_Human0.89029276
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88777051
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88043927
88RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84923652
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84720397
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.83553335
91IGF1R_20145208_ChIP-Seq_DFB_Human0.83118814
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80823014
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78944877
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77829189
95FUS_26573619_Chip-Seq_HEK293_Human0.76575551
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74013640
97IRF1_19129219_ChIP-ChIP_H3396_Human0.72439132
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71910370
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71867856
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70108122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.52825838
2MP0008058_abnormal_DNA_repair4.18666230
3MP0003693_abnormal_embryo_hatching3.85455165
4MP0004957_abnormal_blastocyst_morpholog3.43388878
5MP0005171_absent_coat_pigmentation3.19901369
6MP0003111_abnormal_nucleus_morphology3.15001224
7MP0003077_abnormal_cell_cycle3.08930494
8MP0008057_abnormal_DNA_replication3.03413697
9MP0000372_irregular_coat_pigmentation2.88032923
10MP0003941_abnormal_skin_development2.86157274
11MP0003718_maternal_effect2.56490922
12MP0008877_abnormal_DNA_methylation2.54833272
13MP0008932_abnormal_embryonic_tissue2.54589667
14MP0003786_premature_aging2.47844005
15MP0008007_abnormal_cellular_replicative2.42001125
16MP0003806_abnormal_nucleotide_metabolis2.30161730
17MP0006035_abnormal_mitochondrial_morpho2.17652573
18MP0008995_early_reproductive_senescence2.13493445
19MP0001529_abnormal_vocalization2.01134584
20MP0009697_abnormal_copulation1.84480131
21MP0008789_abnormal_olfactory_epithelium1.78677320
22MP0003136_yellow_coat_color1.74478761
23MP0006036_abnormal_mitochondrial_physio1.69322812
24MP0005257_abnormal_intraocular_pressure1.66593900
25MP0006072_abnormal_retinal_apoptosis1.65896202
26MP0000358_abnormal_cell_content/1.60784690
27MP0003890_abnormal_embryonic-extraembry1.58040526
28MP0005367_renal/urinary_system_phenotyp1.45426241
29MP0000516_abnormal_urinary_system1.45426241
30MP0001730_embryonic_growth_arrest1.44582525
31MP0000350_abnormal_cell_proliferation1.42340003
32MP0002095_abnormal_skin_pigmentation1.40547637
33MP0000537_abnormal_urethra_morphology1.35700783
34MP0002254_reproductive_system_inflammat1.32855001
35MP0003186_abnormal_redox_activity1.31848066
36MP0005075_abnormal_melanosome_morpholog1.31560117
37MP0002938_white_spotting1.30435594
38MP0001293_anophthalmia1.30040294
39MP0002638_abnormal_pupillary_reflex1.27435458
40MP0010307_abnormal_tumor_latency1.25475778
41MP0002822_catalepsy1.23235608
42MP0006292_abnormal_olfactory_placode1.23122741
43MP0001697_abnormal_embryo_size1.22308912
44MP0002751_abnormal_autonomic_nervous1.21489936
45MP0005499_abnormal_olfactory_system1.21157542
46MP0005394_taste/olfaction_phenotype1.21157542
47MP0005380_embryogenesis_phenotype1.20309546
48MP0001672_abnormal_embryogenesis/_devel1.20309546
49MP0003315_abnormal_perineum_morphology1.17318694
50MP0000313_abnormal_cell_death1.17254950
51MP0002102_abnormal_ear_morphology1.15607960
52MP0002160_abnormal_reproductive_system1.13993305
53MP0003937_abnormal_limbs/digits/tail_de1.13306616
54MP0002210_abnormal_sex_determination1.12528435
55MP0002080_prenatal_lethality1.07507976
56MP0002396_abnormal_hematopoietic_system1.06730662
57MP0002084_abnormal_developmental_patter1.04728587
58MP0005408_hypopigmentation1.03770944
59MP0004133_heterotaxia1.03439106
60MP0001929_abnormal_gametogenesis1.01994229
61MP0001919_abnormal_reproductive_system1.01779755
62MP0003984_embryonic_growth_retardation1.01767199
63MP0002088_abnormal_embryonic_growth/wei1.00800814
64MP0001145_abnormal_male_reproductive0.98760232
65MP0002233_abnormal_nose_morphology0.98186109
66MP0002019_abnormal_tumor_incidence0.97904710
67MP0002085_abnormal_embryonic_tissue0.97214723
68MP0005389_reproductive_system_phenotype0.94476034
69MP0004197_abnormal_fetal_growth/weight/0.92485781
70MP0000647_abnormal_sebaceous_gland0.92180828
71MP0005253_abnormal_eye_physiology0.90772401
72MP0000653_abnormal_sex_gland0.88927239
73MP0009672_abnormal_birth_weight0.82831281
74MP0000569_abnormal_digit_pigmentation0.81818122
75MP0003385_abnormal_body_wall0.80470615
76MP0002111_abnormal_tail_morphology0.80056827
77MP0003567_abnormal_fetal_cardiomyocyte0.77493878
78MP0000015_abnormal_ear_pigmentation0.76144406
79MP0002653_abnormal_ependyma_morphology0.73624571
80MP0001324_abnormal_eye_pigmentation0.73114272
81MP0003119_abnormal_digestive_system0.72211140
82MP0009379_abnormal_foot_pigmentation0.71959593
83MP0005647_abnormal_sex_gland0.70922173
84MP0001727_abnormal_embryo_implantation0.69687126
85MP0001984_abnormal_olfaction0.69342523
86MP0001286_abnormal_eye_development0.67045806
87MP0010352_gastrointestinal_tract_polyps0.66706959
88MP0000049_abnormal_middle_ear0.65140818
89MP0002697_abnormal_eye_size0.65007095
90MP0005220_abnormal_exocrine_pancreas0.64614590
91MP0000631_abnormal_neuroendocrine_gland0.64359817
92MP0003221_abnormal_cardiomyocyte_apopto0.64298274
93MP0002163_abnormal_gland_morphology0.64206010
94MP0005391_vision/eye_phenotype0.64043643
95MP0002090_abnormal_vision0.63947387
96MP0002234_abnormal_pharynx_morphology0.63518782
97MP0002736_abnormal_nociception_after0.63041118
98MP0001119_abnormal_female_reproductive0.62535887
99MP0002177_abnormal_outer_ear0.62376868
100MP0003699_abnormal_female_reproductive0.61604644

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)4.34946525
2Colon cancer (HP:0003003)4.24521129
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.16092886
4Hepatocellular necrosis (HP:0001404)4.03598727
5Increased CSF lactate (HP:0002490)4.03085209
6Chromsome breakage (HP:0040012)4.02734315
7Mitochondrial inheritance (HP:0001427)4.01592634
8Acute necrotizing encephalopathy (HP:0006965)4.00929332
9Abnormal mitochondria in muscle tissue (HP:0008316)3.65006303
10Acute encephalopathy (HP:0006846)3.57925278
11Increased hepatocellular lipid droplets (HP:0006565)3.57698112
12Hepatic necrosis (HP:0002605)3.42598333
13Lipid accumulation in hepatocytes (HP:0006561)3.31498494
14Reticulocytopenia (HP:0001896)3.13151715
15Progressive macrocephaly (HP:0004481)3.12193497
16Increased serum lactate (HP:0002151)3.03358213
17Cerebral edema (HP:0002181)2.98274832
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96478560
19Birth length less than 3rd percentile (HP:0003561)2.88651199
20Abnormal number of erythroid precursors (HP:0012131)2.88047013
21Type I transferrin isoform profile (HP:0003642)2.85787256
223-Methylglutaconic aciduria (HP:0003535)2.85738783
23Abnormality of cells of the erythroid lineage (HP:0012130)2.81624625
24Abnormality of chromosome stability (HP:0003220)2.74222854
25Lactic acidosis (HP:0003128)2.73955808
26Abnormality of the preputium (HP:0100587)2.73649861
27Abnormal protein glycosylation (HP:0012346)2.69377997
28Abnormal glycosylation (HP:0012345)2.69377997
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69377997
30Abnormal protein N-linked glycosylation (HP:0012347)2.69377997
31Meckel diverticulum (HP:0002245)2.63713808
32Multiple enchondromatosis (HP:0005701)2.61881213
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.58831049
34Abnormality of the ileum (HP:0001549)2.56583007
35Increased serum pyruvate (HP:0003542)2.53524113
36Abnormality of the labia minora (HP:0012880)2.51867164
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47927957
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47927957
39Increased intramyocellular lipid droplets (HP:0012240)2.37916379
40Abnormality of glycolysis (HP:0004366)2.37397890
41Respiratory failure (HP:0002878)2.36355822
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34282603
43Renal Fanconi syndrome (HP:0001994)2.34034061
44Testicular atrophy (HP:0000029)2.30879862
45Progressive muscle weakness (HP:0003323)2.28898705
46Exercise intolerance (HP:0003546)2.26029431
47Duodenal stenosis (HP:0100867)2.20538758
48Small intestinal stenosis (HP:0012848)2.20538758
49Cleft eyelid (HP:0000625)2.19661027
50Sensory axonal neuropathy (HP:0003390)2.17712693
51Carpal bone hypoplasia (HP:0001498)2.17249715
52Methylmalonic acidemia (HP:0002912)2.15531250
53Leukodystrophy (HP:0002415)2.12074062
54Hypoplastic pelvis (HP:0008839)2.11931104
55Oral leukoplakia (HP:0002745)2.09097060
56Macrocytic anemia (HP:0001972)2.07194856
57Aplastic anemia (HP:0001915)2.05768026
58Respiratory difficulties (HP:0002880)2.01266897
59Reduced antithrombin III activity (HP:0001976)1.99190601
60Optic disc pallor (HP:0000543)1.98196166
61Triphalangeal thumb (HP:0001199)1.96388631
62Methylmalonic aciduria (HP:0012120)1.95252244
63Facial cleft (HP:0002006)1.93438828
64Esophageal atresia (HP:0002032)1.93000282
65Pancytopenia (HP:0001876)1.90469482
66Abnormality of the duodenum (HP:0002246)1.87998769
67Increased muscle lipid content (HP:0009058)1.87282377
68Patchy hypopigmentation of hair (HP:0011365)1.85712885
69Sloping forehead (HP:0000340)1.85119583
70Myelodysplasia (HP:0002863)1.83062421
71Absent radius (HP:0003974)1.82341539
72Cerebral hypomyelination (HP:0006808)1.81153436
73Bifid tongue (HP:0010297)1.78832399
74Abnormal lung lobation (HP:0002101)1.78460664
75Horseshoe kidney (HP:0000085)1.78287605
76Progressive external ophthalmoplegia (HP:0000590)1.77632871
77CNS demyelination (HP:0007305)1.77607584
78Stenosis of the external auditory canal (HP:0000402)1.76061890
79Medulloblastoma (HP:0002885)1.73715898
80Cellular immunodeficiency (HP:0005374)1.73066713
81Absent forearm bone (HP:0003953)1.72606596
82Aplasia involving forearm bones (HP:0009822)1.72606596
83Hyperglycinemia (HP:0002154)1.72287960
84Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70981527
85Rhabdomyosarcoma (HP:0002859)1.69909478
86Premature graying of hair (HP:0002216)1.69370965
87Lethargy (HP:0001254)1.68485306
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67241314
89Neoplasm of the adrenal gland (HP:0100631)1.65008983
90Sparse eyelashes (HP:0000653)1.64281359
91Nephroblastoma (Wilms tumor) (HP:0002667)1.64047550
92Emotional lability (HP:0000712)1.63031244
93Dyschromatopsia (HP:0007641)1.62225890
94Premature ovarian failure (HP:0008209)1.62115997
95Preaxial hand polydactyly (HP:0001177)1.61075656
96Renal cortical cysts (HP:0000803)1.60943010
97Abnormality of methionine metabolism (HP:0010901)1.60887778
98Neoplasm of the colon (HP:0100273)1.59209310
99Cortical dysplasia (HP:0002539)1.58295104
100Optic nerve coloboma (HP:0000588)1.58195525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.72658884
2ZAK3.42199174
3SRPK13.37435688
4CDC72.96116807
5TTK2.71375198
6PBK2.59066453
7PLK42.42787738
8TLK12.39929136
9NME22.38286636
10BUB12.37863670
11NEK12.37533044
12TSSK62.36612378
13MST42.16011788
14BCKDK2.15143107
15VRK12.13469815
16MAP4K21.99052007
17WEE11.95406831
18ATR1.70632911
19MAP3K41.70238658
20PASK1.70053798
21PIM21.69514708
22NME11.68117004
23PDK21.67560385
24TAOK21.62941452
25TRIM281.59270387
26PLK31.56772302
27MKNK11.56636734
28PLK11.54732179
29WNK31.53503594
30MAP2K71.49724211
31CHEK21.49453180
32STK161.43784609
33MAP2K61.41643208
34NUAK11.35661682
35AURKB1.34342744
36EIF2AK31.32859815
37CSNK1G31.30879637
38EIF2AK11.27084143
39CSNK1G11.24276620
40CSNK1A1L1.20655511
41BRSK21.17486135
42BMPR1B1.16906445
43CDK71.16371129
44MKNK21.10959691
45AURKA1.05643172
46KDR1.03040045
47MAP3K100.95808469
48CHEK10.93628209
49ATM0.90894362
50TAF10.88655484
51CSNK1G20.87447534
52CDK80.86956478
53DYRK20.86816376
54BCR0.81769544
55ERBB30.79636772
56STK40.79458881
57BRSK10.77020856
58RPS6KA40.75585943
59RPS6KA50.74395808
60DYRK30.74021974
61CCNB10.73061508
62PINK10.72628059
63PIM10.70208613
64SCYL20.69373503
65CDK90.68972637
66STK38L0.68631635
67RPS6KB20.68547379
68CLK10.66596478
69ADRBK20.63848140
70CSNK2A20.62719088
71ERBB40.61642157
72TESK20.60010957
73CDK40.59772446
74CSNK2A10.59524654
75NLK0.59399215
76CDK10.56767551
77DAPK10.54352189
78GRK10.53061075
79MAP3K80.51344581
80CDK20.49609488
81FGFR10.48355847
82ARAF0.46008374
83NEK20.44915958
84PAK40.44305300
85GRK60.44003805
86DAPK30.43937006
87NEK60.43357709
88TEC0.42368253
89EIF2AK20.37019984
90AKT20.36611693
91MAP3K50.36352129
92EPHA30.35689018
93MAP3K120.34623093
94BRD40.34492574
95RAF10.32134610
96MAPKAPK50.32072577
97PRKCI0.31328996
98CDK120.30003897
99PRKDC0.29859707
100CSNK1E0.26651688

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.90862415
2Proteasome_Homo sapiens_hsa030503.57914157
3RNA polymerase_Homo sapiens_hsa030203.51929763
4Mismatch repair_Homo sapiens_hsa034303.45375285
5Ribosome_Homo sapiens_hsa030103.08860282
6Base excision repair_Homo sapiens_hsa034103.00319165
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98305189
8Homologous recombination_Homo sapiens_hsa034402.94703253
9Oxidative phosphorylation_Homo sapiens_hsa001902.73045729
10Parkinsons disease_Homo sapiens_hsa050122.48790146
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45173665
12Spliceosome_Homo sapiens_hsa030402.43924654
13Non-homologous end-joining_Homo sapiens_hsa034502.39433180
14Protein export_Homo sapiens_hsa030602.25770218
15Fanconi anemia pathway_Homo sapiens_hsa034602.20578787
16Pyrimidine metabolism_Homo sapiens_hsa002402.19046120
17Nucleotide excision repair_Homo sapiens_hsa034202.11705716
18RNA transport_Homo sapiens_hsa030132.08183595
19Huntingtons disease_Homo sapiens_hsa050161.98982697
20RNA degradation_Homo sapiens_hsa030181.90116276
21One carbon pool by folate_Homo sapiens_hsa006701.77461490
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75286720
23Cell cycle_Homo sapiens_hsa041101.72235781
24Basal transcription factors_Homo sapiens_hsa030221.61697665
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.61003444
26Alzheimers disease_Homo sapiens_hsa050101.57077611
27Fatty acid elongation_Homo sapiens_hsa000621.57007264
28Propanoate metabolism_Homo sapiens_hsa006401.48246903
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42511833
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41351557
31Purine metabolism_Homo sapiens_hsa002301.40083445
32Steroid biosynthesis_Homo sapiens_hsa001001.32697240
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32469042
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30269853
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27187065
36Pyruvate metabolism_Homo sapiens_hsa006201.23138274
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18308082
38Systemic lupus erythematosus_Homo sapiens_hsa053221.10202302
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09925432
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08053840
41Biosynthesis of amino acids_Homo sapiens_hsa012301.06731522
42p53 signaling pathway_Homo sapiens_hsa041151.01361510
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01064983
44Folate biosynthesis_Homo sapiens_hsa007901.00196164
45Selenocompound metabolism_Homo sapiens_hsa004500.97563875
46mRNA surveillance pathway_Homo sapiens_hsa030150.97550574
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87501671
48Glutathione metabolism_Homo sapiens_hsa004800.87064551
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86606128
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85567433
51Carbon metabolism_Homo sapiens_hsa012000.82966027
52Sulfur relay system_Homo sapiens_hsa041220.82879922
53Metabolic pathways_Homo sapiens_hsa011000.77698132
54Cardiac muscle contraction_Homo sapiens_hsa042600.75600700
55Alcoholism_Homo sapiens_hsa050340.74298983
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69847016
57N-Glycan biosynthesis_Homo sapiens_hsa005100.67177111
58Oocyte meiosis_Homo sapiens_hsa041140.65895571
59Vitamin B6 metabolism_Homo sapiens_hsa007500.63933941
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59253637
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56861938
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.56361874
63Epstein-Barr virus infection_Homo sapiens_hsa051690.53975050
64Peroxisome_Homo sapiens_hsa041460.53403039
65Pentose phosphate pathway_Homo sapiens_hsa000300.48189405
66Butanoate metabolism_Homo sapiens_hsa006500.46111795
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42533580
68Fatty acid metabolism_Homo sapiens_hsa012120.41103789
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39677500
70TGF-beta signaling pathway_Homo sapiens_hsa043500.35357087
71Lysine degradation_Homo sapiens_hsa003100.35309345
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34313979
73Nitrogen metabolism_Homo sapiens_hsa009100.32836803
74Regulation of autophagy_Homo sapiens_hsa041400.32178360
75Viral carcinogenesis_Homo sapiens_hsa052030.27935892
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24333572
77Sulfur metabolism_Homo sapiens_hsa009200.24317568
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20814020
79Primary immunodeficiency_Homo sapiens_hsa053400.20142428
80Tryptophan metabolism_Homo sapiens_hsa003800.19837428
81Tyrosine metabolism_Homo sapiens_hsa003500.19806149
82Phototransduction_Homo sapiens_hsa047440.16867465
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16690522
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16249806
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16038877
86Sphingolipid metabolism_Homo sapiens_hsa006000.15668859
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15345334
88Fructose and mannose metabolism_Homo sapiens_hsa000510.15150527
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.13864540
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12641881
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12541424
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.12360228
93Arginine and proline metabolism_Homo sapiens_hsa003300.12076054
94Thyroid cancer_Homo sapiens_hsa052160.10778715
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.10358356
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10177260
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08130925
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06612574
99Herpes simplex infection_Homo sapiens_hsa051680.05632523
100Bladder cancer_Homo sapiens_hsa052190.05585569

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