ZNF74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.06475661
2DNA replication checkpoint (GO:0000076)3.48089354
3presynaptic membrane organization (GO:0097090)3.31476068
4replication fork processing (GO:0031297)3.28775852
5DNA damage response, detection of DNA damage (GO:0042769)3.26632179
6regulation of nuclear cell cycle DNA replication (GO:0033262)3.23053730
7regulation of mitotic spindle checkpoint (GO:1903504)3.19179233
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19179233
9nucleobase catabolic process (GO:0046113)3.15291503
10presynaptic membrane assembly (GO:0097105)3.02610608
11DNA double-strand break processing (GO:0000729)2.98708833
12behavioral response to nicotine (GO:0035095)2.98658849
13establishment of mitochondrion localization (GO:0051654)2.98150394
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94455016
15spinal cord development (GO:0021510)2.87516555
16negative regulation of telomere maintenance (GO:0032205)2.82483166
17somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79998375
18somatic hypermutation of immunoglobulin genes (GO:0016446)2.79998375
19neural tube formation (GO:0001841)2.79756429
20resolution of meiotic recombination intermediates (GO:0000712)2.79431320
21maturation of SSU-rRNA (GO:0030490)2.75470962
22nonmotile primary cilium assembly (GO:0035058)2.73865640
23peptidyl-histidine modification (GO:0018202)2.73717570
24pseudouridine synthesis (GO:0001522)2.69856039
25regulation of posttranscriptional gene silencing (GO:0060147)2.64360020
26regulation of gene silencing by miRNA (GO:0060964)2.64360020
27regulation of gene silencing by RNA (GO:0060966)2.64360020
28mitochondrion transport along microtubule (GO:0047497)2.60752554
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.60752554
30chromatin remodeling at centromere (GO:0031055)2.56120070
31ribosomal small subunit assembly (GO:0000028)2.53078811
32regulation of development, heterochronic (GO:0040034)2.51675619
33translesion synthesis (GO:0019985)2.51399111
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.50965081
35L-serine metabolic process (GO:0006563)2.50064115
36neuron cell-cell adhesion (GO:0007158)2.49941484
37somite development (GO:0061053)2.45839509
38tongue development (GO:0043586)2.45077281
39axonal fasciculation (GO:0007413)2.44322757
40regulation of telomere maintenance (GO:0032204)2.43180455
41postsynaptic membrane organization (GO:0001941)2.41325729
42negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39779044
43mitochondrial respiratory chain complex assembly (GO:0033108)2.39606493
44negative regulation of translation, ncRNA-mediated (GO:0040033)2.39110195
45regulation of translation, ncRNA-mediated (GO:0045974)2.39110195
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39110195
47protein polyglutamylation (GO:0018095)2.38797122
48DNA replication-dependent nucleosome assembly (GO:0006335)2.37476611
49DNA replication-dependent nucleosome organization (GO:0034723)2.37476611
50DNA topological change (GO:0006265)2.37306288
51forebrain neuron differentiation (GO:0021879)2.36596681
52hindbrain development (GO:0030902)2.35235035
53neuron recognition (GO:0008038)2.34462180
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.34286394
55mitochondrial respiratory chain complex I assembly (GO:0032981)2.34286394
56NADH dehydrogenase complex assembly (GO:0010257)2.34286394
57pre-miRNA processing (GO:0031054)2.33725590
58protein complex biogenesis (GO:0070271)2.33044842
59limb bud formation (GO:0060174)2.31809269
60mitochondrial RNA metabolic process (GO:0000959)2.31791347
61histone H2A acetylation (GO:0043968)2.31190423
62negative regulation of DNA-dependent DNA replication (GO:2000104)2.31116814
63regulation of timing of cell differentiation (GO:0048505)2.30524807
64retinal ganglion cell axon guidance (GO:0031290)2.30337640
65neurotransmitter-gated ion channel clustering (GO:0072578)2.30114520
66negative regulation of mRNA processing (GO:0050686)2.29844386
67negative regulation of RNA splicing (GO:0033119)2.28453420
68cell proliferation in forebrain (GO:0021846)2.27165997
69head development (GO:0060322)2.26865123
70microtubule depolymerization (GO:0007019)2.25895322
71chromatin assembly (GO:0031497)2.23909603
72intraciliary transport (GO:0042073)2.22387425
73nucleosome disassembly (GO:0006337)2.22207295
74protein-DNA complex disassembly (GO:0032986)2.22207295
75kidney morphogenesis (GO:0060993)2.22145304
76recombinational repair (GO:0000725)2.21273892
77cell migration in hindbrain (GO:0021535)2.19853913
78heterochromatin organization (GO:0070828)2.19311546
79kinetochore assembly (GO:0051382)2.18926966
80behavioral response to ethanol (GO:0048149)2.18364340
81ubiquinone metabolic process (GO:0006743)2.18144816
82DNA strand elongation involved in DNA replication (GO:0006271)2.17949314
83nucleobase biosynthetic process (GO:0046112)2.17919188
84protein-cofactor linkage (GO:0018065)2.17648624
85translational termination (GO:0006415)2.17228496
86CENP-A containing nucleosome assembly (GO:0034080)2.16975826
87double-strand break repair via homologous recombination (GO:0000724)2.16583225
88pituitary gland development (GO:0021983)2.15767684
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.15291587
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.15291587
91cell differentiation in spinal cord (GO:0021515)2.14553632
92reciprocal meiotic recombination (GO:0007131)2.13461118
93reciprocal DNA recombination (GO:0035825)2.13461118
94viral transcription (GO:0019083)2.12535314
95regulation of telomere maintenance via telomerase (GO:0032210)2.11412475
96protein localization to synapse (GO:0035418)2.11334287
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.09826558
98centriole replication (GO:0007099)2.08918561
99neuronal stem cell maintenance (GO:0097150)2.08626896
100mRNA splice site selection (GO:0006376)2.08392056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.35472206
2EZH2_22144423_ChIP-Seq_EOC_Human3.80206230
3E2F7_22180533_ChIP-Seq_HELA_Human3.51329521
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97675403
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.94667555
6ZNF274_21170338_ChIP-Seq_K562_Hela2.72912049
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70142374
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56336754
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49184904
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.42133579
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.40506240
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33820644
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32472645
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.27249084
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.14861599
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.09049021
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08346098
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07962162
19IGF1R_20145208_ChIP-Seq_DFB_Human1.99601254
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91162602
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86472474
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86124297
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82730892
24MYC_18940864_ChIP-ChIP_HL60_Human1.79162513
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71775039
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.69573828
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69175545
28XRN2_22483619_ChIP-Seq_HELA_Human1.67708261
29VDR_22108803_ChIP-Seq_LS180_Human1.67223239
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.65823316
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.65562039
32IRF1_19129219_ChIP-ChIP_H3396_Human1.61177723
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60413579
34* EWS_26573619_Chip-Seq_HEK293_Human1.59715570
35TTF2_22483619_ChIP-Seq_HELA_Human1.58910209
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58158199
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.57711622
38FUS_26573619_Chip-Seq_HEK293_Human1.57219362
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51908734
40* GABP_19822575_ChIP-Seq_HepG2_Human1.47428033
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46544111
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44935467
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43771006
44GBX2_23144817_ChIP-Seq_PC3_Human1.41800023
45RNF2_27304074_Chip-Seq_NSC_Mouse1.41297243
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38770010
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36774577
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35114844
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.34683445
50VDR_23849224_ChIP-Seq_CD4+_Human1.34488012
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34203217
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32760799
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.32538070
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29108042
55ELK1_19687146_ChIP-ChIP_HELA_Human1.28146811
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27943489
57FOXP3_21729870_ChIP-Seq_TREG_Human1.27185255
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25439183
59KDM5A_27292631_Chip-Seq_BREAST_Human1.25383118
60REST_21632747_ChIP-Seq_MESCs_Mouse1.25296320
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24820443
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22040633
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.16458385
64DCP1A_22483619_ChIP-Seq_HELA_Human1.10144221
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09472139
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08756913
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08584121
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07902569
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07208724
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06504939
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.05975840
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05360443
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05360443
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04213263
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03974142
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.03586146
77P300_19829295_ChIP-Seq_ESCs_Human1.02544080
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02517953
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00218283
80TAF15_26573619_Chip-Seq_HEK293_Human0.99141979
81TP53_22573176_ChIP-Seq_HFKS_Human0.99050688
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99042804
83NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98809730
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98679294
85MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98637273
86GATA1_26923725_Chip-Seq_HPCs_Mouse0.98347602
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95192211
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94853251
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.94278778
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91829793
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90817568
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.89694001
93JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88897015
94SOX9_26525672_Chip-Seq_HEART_Mouse0.88823313
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.88752497
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86644566
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86297758
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85778543
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85391751
100AR_21572438_ChIP-Seq_LNCaP_Human0.85181369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.22968597
2MP0008877_abnormal_DNA_methylation2.45520089
3MP0003122_maternal_imprinting2.28186474
4MP0003136_yellow_coat_color2.26833617
5MP0003121_genomic_imprinting2.16873856
6MP0000778_abnormal_nervous_system2.11081002
7MP0003880_abnormal_central_pattern2.09803417
8MP0002736_abnormal_nociception_after2.08473554
9MP0008058_abnormal_DNA_repair2.03799118
10MP0001529_abnormal_vocalization2.02181078
11MP0003787_abnormal_imprinting1.94345687
12MP0002938_white_spotting1.94113801
13MP0000566_synostosis1.93796038
14MP0003890_abnormal_embryonic-extraembry1.89744057
15MP0002653_abnormal_ependyma_morphology1.88182803
16MP0003693_abnormal_embryo_hatching1.86538391
17MP0001968_abnormal_touch/_nociception1.80812168
18MP0001293_anophthalmia1.80201512
19MP0000631_abnormal_neuroendocrine_gland1.77120351
20MP0004133_heterotaxia1.71874110
21MP0000049_abnormal_middle_ear1.69839044
22MP0006276_abnormal_autonomic_nervous1.69607153
23MP0005394_taste/olfaction_phenotype1.63015997
24MP0005499_abnormal_olfactory_system1.63015997
25MP0008789_abnormal_olfactory_epithelium1.62196454
26MP0010094_abnormal_chromosome_stability1.59223199
27MP0008995_early_reproductive_senescence1.58450453
28MP0003937_abnormal_limbs/digits/tail_de1.57118147
29MP0010030_abnormal_orbit_morphology1.55875258
30MP0004859_abnormal_synaptic_plasticity1.55452397
31MP0003567_abnormal_fetal_cardiomyocyte1.49323279
32MP0003111_abnormal_nucleus_morphology1.48983274
33MP0002249_abnormal_larynx_morphology1.48695753
34MP0002735_abnormal_chemical_nociception1.47469627
35MP0000955_abnormal_spinal_cord1.40474367
36MP0002102_abnormal_ear_morphology1.37293616
37MP0003861_abnormal_nervous_system1.36782199
38MP0003119_abnormal_digestive_system1.35421013
39MP0003938_abnormal_ear_development1.33099540
40MP0008932_abnormal_embryonic_tissue1.33042318
41MP0001188_hyperpigmentation1.30628842
42MP0002751_abnormal_autonomic_nervous1.29683227
43MP0006072_abnormal_retinal_apoptosis1.26393403
44MP0003123_paternal_imprinting1.26344746
45MP0002822_catalepsy1.26159266
46MP0003718_maternal_effect1.24511969
47MP0002184_abnormal_innervation1.22458582
48MP0001984_abnormal_olfaction1.21238855
49MP0003635_abnormal_synaptic_transmissio1.20414002
50MP0002638_abnormal_pupillary_reflex1.19338180
51MP0002233_abnormal_nose_morphology1.17102656
52MP0002697_abnormal_eye_size1.17012724
53MP0005645_abnormal_hypothalamus_physiol1.14989932
54MP0005551_abnormal_eye_electrophysiolog1.14283148
55MP0005423_abnormal_somatic_nervous1.13410335
56MP0002234_abnormal_pharynx_morphology1.13220679
57MP0004142_abnormal_muscle_tone1.11631206
58MP0001286_abnormal_eye_development1.11579233
59MP0002152_abnormal_brain_morphology1.09354831
60MP0002272_abnormal_nervous_system1.09135088
61MP0002557_abnormal_social/conspecific_i1.08901955
62MP0003077_abnormal_cell_cycle1.07297544
63MP0002752_abnormal_somatic_nervous1.06903888
64MP0002063_abnormal_learning/memory/cond1.06671098
65MP0005646_abnormal_pituitary_gland1.06154440
66MP0004147_increased_porphyrin_level1.05876909
67MP0003942_abnormal_urinary_system1.05777657
68MP0004957_abnormal_blastocyst_morpholog1.05004406
69MP0009697_abnormal_copulation1.04081428
70MP0002882_abnormal_neuron_morphology1.03354722
71MP0003385_abnormal_body_wall1.01862687
72MP0002084_abnormal_developmental_patter1.01377848
73MP0009745_abnormal_behavioral_response1.00080969
74MP0002572_abnormal_emotion/affect_behav0.99427694
75MP0002210_abnormal_sex_determination0.98474258
76MP0005253_abnormal_eye_physiology0.98444594
77MP0004811_abnormal_neuron_physiology0.97248282
78MP0009046_muscle_twitch0.96965384
79MP0003283_abnormal_digestive_organ0.96926628
80MP0003755_abnormal_palate_morphology0.95234121
81MP0000537_abnormal_urethra_morphology0.93365933
82MP0002734_abnormal_mechanical_nocicepti0.93198069
83MP0001485_abnormal_pinna_reflex0.93126067
84MP0001486_abnormal_startle_reflex0.92865919
85MP0002111_abnormal_tail_morphology0.92102439
86MP0008057_abnormal_DNA_replication0.91436569
87MP0005391_vision/eye_phenotype0.91168942
88MP0002085_abnormal_embryonic_tissue0.90870078
89MP0002282_abnormal_trachea_morphology0.90718384
90MP0003698_abnormal_male_reproductive0.88933747
91MP0004885_abnormal_endolymph0.88255752
92MP0006035_abnormal_mitochondrial_morpho0.87417132
93MP0001929_abnormal_gametogenesis0.86603442
94MP0005195_abnormal_posterior_eye0.85704155
95MP0003935_abnormal_craniofacial_develop0.85091397
96MP0002067_abnormal_sensory_capabilities0.85024115
97MP0001145_abnormal_male_reproductive0.82534504
98MP0003315_abnormal_perineum_morphology0.81893675
99MP0004145_abnormal_muscle_electrophysio0.81048857
100MP0009379_abnormal_foot_pigmentation0.80588557

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.13389469
2Reticulocytopenia (HP:0001896)2.99080011
3Pancreatic fibrosis (HP:0100732)2.72800775
4True hermaphroditism (HP:0010459)2.69965147
5Septo-optic dysplasia (HP:0100842)2.65586583
6Pancreatic cysts (HP:0001737)2.65007389
7Abnormality of cells of the erythroid lineage (HP:0012130)2.63324309
8Cortical dysplasia (HP:0002539)2.62399959
9Abnormal number of erythroid precursors (HP:0012131)2.56506569
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53175067
11Nephronophthisis (HP:0000090)2.52633063
12Pendular nystagmus (HP:0012043)2.51673593
13Rib fusion (HP:0000902)2.49843224
14Chromsome breakage (HP:0040012)2.42106807
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.41936152
16Patellar aplasia (HP:0006443)2.38065391
17Colon cancer (HP:0003003)2.37527817
18Gait imbalance (HP:0002141)2.34859136
19Sclerocornea (HP:0000647)2.31975197
20Molar tooth sign on MRI (HP:0002419)2.29301325
21Abnormality of midbrain morphology (HP:0002418)2.29301325
22Meckel diverticulum (HP:0002245)2.29105698
23Medial flaring of the eyebrow (HP:0010747)2.26875177
24Abnormality of the ileum (HP:0001549)2.25751919
25Lissencephaly (HP:0001339)2.24479373
26Aplasia/Hypoplasia of the patella (HP:0006498)2.19000728
27Abnormality of the aortic arch (HP:0012303)2.15155222
28Birth length less than 3rd percentile (HP:0003561)2.14436969
29Anencephaly (HP:0002323)2.11550283
30Congenital primary aphakia (HP:0007707)2.11462252
31Retinal dysplasia (HP:0007973)2.10880708
32Nephrogenic diabetes insipidus (HP:0009806)2.04968645
33Hyperglycinemia (HP:0002154)2.03916595
34Ectopic kidney (HP:0000086)2.00070714
35Supernumerary spleens (HP:0009799)2.00062639
36Triphalangeal thumb (HP:0001199)1.98878976
37High anterior hairline (HP:0009890)1.98714972
38Abnormality of the carotid arteries (HP:0005344)1.98060138
39Abnormality of the renal medulla (HP:0100957)1.96725705
40Abnormality of the diencephalon (HP:0010662)1.96439901
41Preaxial hand polydactyly (HP:0001177)1.94840093
42Pachygyria (HP:0001302)1.91560718
43Anophthalmia (HP:0000528)1.91433277
44Vaginal atresia (HP:0000148)1.87139948
45Genital tract atresia (HP:0001827)1.86818716
46Abnormal lung lobation (HP:0002101)1.85280343
47Postaxial foot polydactyly (HP:0001830)1.85204158
48Renal hypoplasia (HP:0000089)1.84155556
49Optic nerve hypoplasia (HP:0000609)1.83090576
50Absent thumb (HP:0009777)1.81277166
51Congenital stationary night blindness (HP:0007642)1.80950936
52Absent septum pellucidum (HP:0001331)1.80770075
53Microvesicular hepatic steatosis (HP:0001414)1.80747182
54Acute necrotizing encephalopathy (HP:0006965)1.80532462
55Poor coordination (HP:0002370)1.80344233
56Limb dystonia (HP:0002451)1.77503001
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77003164
58Acute encephalopathy (HP:0006846)1.76323812
59Horseshoe kidney (HP:0000085)1.75897466
60Aganglionic megacolon (HP:0002251)1.75258802
61Cystic liver disease (HP:0006706)1.75065271
62Esophageal atresia (HP:0002032)1.74342495
63Oligodactyly (HP:0012165)1.73739608
64Abnormality of the preputium (HP:0100587)1.73657602
65Tubulointerstitial nephritis (HP:0001970)1.73643865
66Drooling (HP:0002307)1.72568002
67Ependymoma (HP:0002888)1.72053988
68Micropenis (HP:0000054)1.71166683
69Aplasia/Hypoplasia of the sternum (HP:0006714)1.70906234
70Specific learning disability (HP:0001328)1.70575901
71Optic nerve coloboma (HP:0000588)1.69727904
72Broad-based gait (HP:0002136)1.69175984
73Postaxial hand polydactyly (HP:0001162)1.68148064
74Abnormality of DNA repair (HP:0003254)1.67436807
75Sloping forehead (HP:0000340)1.67124650
76Male pseudohermaphroditism (HP:0000037)1.65549441
77Abnormal mitochondria in muscle tissue (HP:0008316)1.64996409
78Polymicrogyria (HP:0002126)1.63936637
79Poor suck (HP:0002033)1.62688433
80Narrow forehead (HP:0000341)1.62551773
81Abnormality of chromosome stability (HP:0003220)1.61376442
82Holoprosencephaly (HP:0001360)1.61341902
83Multicystic kidney dysplasia (HP:0000003)1.61064514
84Abnormal number of incisors (HP:0011064)1.60965557
85Bilateral microphthalmos (HP:0007633)1.60955525
86Intestinal atresia (HP:0011100)1.60952299
87Gastrointestinal atresia (HP:0002589)1.60675564
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.60189423
89Oligodactyly (hands) (HP:0001180)1.59554313
90Dandy-Walker malformation (HP:0001305)1.59365474
91Type II lissencephaly (HP:0007260)1.58032555
92Hemivertebrae (HP:0002937)1.57034938
93Impulsivity (HP:0100710)1.56942239
94Morphological abnormality of the inner ear (HP:0011390)1.55597712
95Myelomeningocele (HP:0002475)1.55314812
96Decreased testicular size (HP:0008734)1.54963094
97Elfin facies (HP:0004428)1.54705290
98Abnormality of the septum pellucidum (HP:0007375)1.54296501
99Scrotal hypoplasia (HP:0000046)1.53880509
100Abnormal biliary tract physiology (HP:0012439)1.53654124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK12.96912561
2TRIM282.70059089
3ZAK2.64606860
4WNK32.64020707
5DYRK22.62564649
6CDC72.52079301
7TNIK2.47856507
8MAP3K42.34657354
9CASK2.32291221
10PLK42.25876568
11TSSK62.19104280
12NUAK12.08141322
13SRPK12.00785711
14MAP4K22.00206593
15MAPK131.96506848
16INSRR1.89738926
17MAP2K71.83231495
18MKNK21.81767753
19MKNK11.78001531
20BCKDK1.74569570
21PNCK1.72615797
22WNK41.68401234
23TTK1.65790990
24BMPR1B1.65754054
25BUB11.53914035
26CDK191.47120730
27WEE11.42929685
28NTRK21.40704290
29VRK21.37131847
30PINK11.35972108
31CHEK21.33828955
32PLK31.17879090
33BCR1.16222993
34MAP3K101.15506313
35GRK11.13884663
36DYRK31.13325958
37ATR1.11581478
38EPHA41.11324697
39PLK11.10961745
40VRK11.10178137
41NEK21.07854768
42PASK1.06402830
43NTRK31.06204031
44MINK11.05966078
45PRKCG0.98877673
46TYRO30.97847068
47CCNB10.97650010
48CSNK1G20.96380418
49TLK10.90926335
50NME10.90062619
51CSNK1G10.88850338
52CSNK1G30.88038336
53MAP2K40.86761835
54ADRBK20.83406116
55FGFR20.83252054
56EEF2K0.82562439
57ATM0.81224655
58TAF10.80726465
59FRK0.79001707
60CSNK1A1L0.74743967
61CSNK1E0.74055898
62TGFBR10.70543557
63CHEK10.68032035
64AURKA0.67567022
65PRKD30.62852273
66CDK10.59679522
67SIK20.59371496
68AURKB0.59039402
69CDK20.58909296
70STK390.57535424
71CDK80.57404330
72CAMK1G0.56697540
73DYRK1A0.54249072
74PRKDC0.53607169
75OXSR10.52648153
76UHMK10.51299805
77LATS10.50218156
78CAMK1D0.49895784
79PAK30.48425690
80PKN10.48015778
81PLK20.46373285
82BRSK10.45754420
83PRKCZ0.44357569
84BRSK20.44080769
85PRKCE0.43305577
86CSNK2A20.42933460
87PRKCI0.41341228
88CDK70.40611238
89EPHB20.40482593
90CSNK1A10.40391524
91KSR10.39438541
92RPS6KA40.39403276
93RPS6KA50.38688337
94IRAK10.37686186
95MAPK150.37325954
96CDK180.36986445
97CDK11A0.36907187
98PRKAA10.36112415
99GSK3B0.36088118
100CDK150.35682257

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.74058580
2Fanconi anemia pathway_Homo sapiens_hsa034602.55951399
3Ribosome_Homo sapiens_hsa030102.49942082
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30423784
5Base excision repair_Homo sapiens_hsa034102.15712273
6DNA replication_Homo sapiens_hsa030302.14655719
7Spliceosome_Homo sapiens_hsa030402.14318556
8Nicotine addiction_Homo sapiens_hsa050332.08898902
9RNA polymerase_Homo sapiens_hsa030202.06748675
10Parkinsons disease_Homo sapiens_hsa050121.96203005
11Mismatch repair_Homo sapiens_hsa034301.96008062
12Steroid biosynthesis_Homo sapiens_hsa001001.95418718
13Non-homologous end-joining_Homo sapiens_hsa034501.94917509
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91179891
15Basal transcription factors_Homo sapiens_hsa030221.88025771
16Oxidative phosphorylation_Homo sapiens_hsa001901.86182066
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85024473
18RNA transport_Homo sapiens_hsa030131.81131480
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79157094
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73574949
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73031589
22RNA degradation_Homo sapiens_hsa030181.67355176
23Selenocompound metabolism_Homo sapiens_hsa004501.66197764
24One carbon pool by folate_Homo sapiens_hsa006701.63270165
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58426956
26Sulfur relay system_Homo sapiens_hsa041221.57490953
27Butanoate metabolism_Homo sapiens_hsa006501.52298466
28Phototransduction_Homo sapiens_hsa047441.48196307
29Huntingtons disease_Homo sapiens_hsa050161.48166366
30Nucleotide excision repair_Homo sapiens_hsa034201.47705749
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45030519
32Protein export_Homo sapiens_hsa030601.43207993
33Basal cell carcinoma_Homo sapiens_hsa052171.31252724
34Cell cycle_Homo sapiens_hsa041101.30732547
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.29260197
36Propanoate metabolism_Homo sapiens_hsa006401.24666948
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23745325
38Hedgehog signaling pathway_Homo sapiens_hsa043401.19600097
39Pyrimidine metabolism_Homo sapiens_hsa002401.17842393
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14022260
41mRNA surveillance pathway_Homo sapiens_hsa030151.12066897
42Proteasome_Homo sapiens_hsa030501.03279486
43Alzheimers disease_Homo sapiens_hsa050101.01217957
44Axon guidance_Homo sapiens_hsa043601.00075388
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98682188
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98363511
47Cardiac muscle contraction_Homo sapiens_hsa042600.97134271
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96605873
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95321214
50Ether lipid metabolism_Homo sapiens_hsa005650.93501516
51Purine metabolism_Homo sapiens_hsa002300.93138710
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91845819
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90751755
54Hippo signaling pathway_Homo sapiens_hsa043900.90654454
55GABAergic synapse_Homo sapiens_hsa047270.90451690
56Taste transduction_Homo sapiens_hsa047420.90179783
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89334002
58Olfactory transduction_Homo sapiens_hsa047400.87690257
59Linoleic acid metabolism_Homo sapiens_hsa005910.82736093
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82641393
61Glutamatergic synapse_Homo sapiens_hsa047240.82558783
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80224508
63Lysine degradation_Homo sapiens_hsa003100.77688756
64Morphine addiction_Homo sapiens_hsa050320.77570243
65Oocyte meiosis_Homo sapiens_hsa041140.77521479
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75304667
67Pyruvate metabolism_Homo sapiens_hsa006200.73951220
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72235409
69Biosynthesis of amino acids_Homo sapiens_hsa012300.71550823
70Dopaminergic synapse_Homo sapiens_hsa047280.67135393
71Wnt signaling pathway_Homo sapiens_hsa043100.66751948
72Cocaine addiction_Homo sapiens_hsa050300.65822860
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65460644
74Nitrogen metabolism_Homo sapiens_hsa009100.65409218
75Fatty acid elongation_Homo sapiens_hsa000620.65303636
76Alcoholism_Homo sapiens_hsa050340.65206655
77Metabolic pathways_Homo sapiens_hsa011000.64852215
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63495979
79Circadian entrainment_Homo sapiens_hsa047130.63397835
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.62318579
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61603758
82Long-term depression_Homo sapiens_hsa047300.50805613
83Folate biosynthesis_Homo sapiens_hsa007900.49648755
84Peroxisome_Homo sapiens_hsa041460.47552264
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.46493603
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45121329
87Insulin secretion_Homo sapiens_hsa049110.42488878
88Cholinergic synapse_Homo sapiens_hsa047250.41559397
89Arginine and proline metabolism_Homo sapiens_hsa003300.38028411
90Serotonergic synapse_Homo sapiens_hsa047260.37164965
91p53 signaling pathway_Homo sapiens_hsa041150.35674138
92Fatty acid metabolism_Homo sapiens_hsa012120.33771411
93N-Glycan biosynthesis_Homo sapiens_hsa005100.33665937
94Amphetamine addiction_Homo sapiens_hsa050310.32783305
95Synaptic vesicle cycle_Homo sapiens_hsa047210.31676723
96Tryptophan metabolism_Homo sapiens_hsa003800.31388238
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.30503405
98Fat digestion and absorption_Homo sapiens_hsa049750.28574124
99Melanogenesis_Homo sapiens_hsa049160.27811046
100beta-Alanine metabolism_Homo sapiens_hsa004100.27564213

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