ZNF735

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)6.22213542
2positive regulation of protein homooligomerization (GO:0032464)5.18555492
3meiosis I (GO:0007127)5.08875762
4meiotic chromosome segregation (GO:0045132)4.92587031
5organic cation transport (GO:0015695)4.53915334
6pseudouridine synthesis (GO:0001522)4.31488624
7histamine transport (GO:0051608)4.19559241
8exogenous drug catabolic process (GO:0042738)4.17170453
9response to xenobiotic stimulus (GO:0009410)4.13732837
10transcription from mitochondrial promoter (GO:0006390)4.10706777
11regulation of meiosis I (GO:0060631)4.09954836
12positive regulation of meiosis (GO:0045836)4.03080956
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)30.3631806
14neurotransmitter biosynthetic process (GO:0042136)3.97138830
15rRNA modification (GO:0000154)3.95640061
16positive regulation of meiotic cell cycle (GO:0051446)3.93992444
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.91980720
18negative regulation of organelle assembly (GO:1902116)3.88015187
19piRNA metabolic process (GO:0034587)3.81182470
20antigen processing and presentation via MHC class Ib (GO:0002475)3.75456217
21rRNA methylation (GO:0031167)3.72541057
22maturation of 5.8S rRNA (GO:0000460)3.67470192
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63827724
24drug transmembrane transport (GO:0006855)3.61719898
25drinking behavior (GO:0042756)3.44021399
26male meiosis (GO:0007140)3.43184553
27multicellular organism reproduction (GO:0032504)3.42693486
28protein K6-linked ubiquitination (GO:0085020)3.40277767
29resolution of meiotic recombination intermediates (GO:0000712)3.37704868
30positive regulation of guanylate cyclase activity (GO:0031284)3.37648293
31negative regulation of epidermal cell differentiation (GO:0045605)3.33868879
32regulation of acrosome reaction (GO:0060046)3.33372774
33histone-serine phosphorylation (GO:0035404)3.31061289
34behavioral response to nicotine (GO:0035095)3.30277342
35atrial cardiac muscle cell action potential (GO:0086014)3.28321619
36protein polyglutamylation (GO:0018095)3.26900068
37negative regulation of telomere maintenance (GO:0032205)3.26672512
38regulation of DNA methylation (GO:0044030)3.26005857
39kidney morphogenesis (GO:0060993)3.22278060
40reciprocal meiotic recombination (GO:0007131)3.16840640
41reciprocal DNA recombination (GO:0035825)3.16840640
42histone phosphorylation (GO:0016572)3.16424033
43drug catabolic process (GO:0042737)3.14940839
44DNA deamination (GO:0045006)3.14279569
45neurotransmitter metabolic process (GO:0042133)3.14145269
46negative regulation of transcription regulatory region DNA binding (GO:2000678)3.13610911
47rRNA catabolic process (GO:0016075)3.12815782
48bone trabecula formation (GO:0060346)3.10194106
49tooth mineralization (GO:0034505)3.07916750
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05749398
51positive regulation of protein oligomerization (GO:0032461)3.04918455
52meiotic cell cycle (GO:0051321)3.04855775
53arginine catabolic process (GO:0006527)3.04050809
54regulation of guanylate cyclase activity (GO:0031282)3.02024132
55synaptonemal complex assembly (GO:0007130)3.01081235
56regulation of retinoic acid receptor signaling pathway (GO:0048385)25.4829541
57regulation of cytokine production involved in inflammatory response (GO:1900015)2.93569425
58retinal cone cell development (GO:0046549)2.93508158
59synaptonemal complex organization (GO:0070193)2.87355474
60DNA methylation involved in gamete generation (GO:0043046)2.86193870
61detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.84582999
62RNA localization (GO:0006403)2.84259626
63DNA-dependent DNA replication (GO:0006261)2.83355351
64regulation of immune response to tumor cell (GO:0002837)2.80095610
65regulation of response to tumor cell (GO:0002834)2.80095610
66positive regulation of response to tumor cell (GO:0002836)2.80095610
67positive regulation of immune response to tumor cell (GO:0002839)2.80095610
68meiotic cell cycle process (GO:1903046)2.79383946
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.78772851
70negative regulation of epidermis development (GO:0045683)2.77480334
71regulation of glucokinase activity (GO:0033131)2.76445965
72regulation of hexokinase activity (GO:1903299)2.76445965
73detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.73692842
74detection of chemical stimulus involved in sensory perception (GO:0050907)2.73080579
75regulation of meiosis (GO:0040020)2.72070597
76histone H2A monoubiquitination (GO:0035518)2.72049816
77snRNA transcription (GO:0009301)2.67908395
78regulation of hippo signaling (GO:0035330)2.66279168
79glycine transport (GO:0015816)2.64106282
80tRNA methylation (GO:0030488)2.63656509
81regulation of female gonad development (GO:2000194)2.63634547
82quaternary ammonium group transport (GO:0015697)2.62372726
83positive regulation of sodium ion transmembrane transport (GO:1902307)2.59020344
84polyamine biosynthetic process (GO:0006596)2.57960598
85positive regulation of cAMP-mediated signaling (GO:0043950)2.55727382
86peristalsis (GO:0030432)2.52872489
87azole transport (GO:0045117)2.49983276
88positive regulation of respiratory burst (GO:0060267)2.47029582
89mitochondrial RNA metabolic process (GO:0000959)2.45844871
90autophagic vacuole assembly (GO:0000045)2.45679625
91regulation of protein homooligomerization (GO:0032462)2.45391689
92gap junction assembly (GO:0016264)2.43996513
93cilium or flagellum-dependent cell motility (GO:0001539)2.43834443
94nitric oxide biosynthetic process (GO:0006809)2.42879980
95drug transport (GO:0015893)2.42750079
96negative regulation of meiosis (GO:0045835)2.40457083
97chromosome organization involved in meiosis (GO:0070192)2.39324943
98adult feeding behavior (GO:0008343)2.39172231
99regulation of histone phosphorylation (GO:0033127)2.37853138
100outflow tract septum morphogenesis (GO:0003148)2.37498258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.25218466
2NOTCH1_21737748_ChIP-Seq_TLL_Human4.59152128
3* ZNF274_21170338_ChIP-Seq_K562_Hela4.13640033
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.94473330
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.94473330
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.94473330
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73765620
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88518554
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76140065
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.52945598
11IRF1_19129219_ChIP-ChIP_H3396_Human2.51513153
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49419206
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28637589
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21411611
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.17971822
16ETV1_20927104_ChIP-Seq_GIST48_Human2.12520613
17NANOG_20526341_ChIP-Seq_ESCs_Human2.10077420
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.02934582
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.96010554
20RBPJ_21746931_ChIP-Seq_IB4_Human1.87530611
21TP53_22573176_ChIP-Seq_HFKS_Human1.80383166
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.77307426
23TBL1_22424771_ChIP-Seq_293T_Human1.74765712
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74043638
25RAC3_21632823_ChIP-Seq_H3396_Human1.73194967
26NFYB_21822215_ChIP-Seq_K562_Human1.72210212
27GATA1_22025678_ChIP-Seq_K562_Human1.71477136
28ERA_21632823_ChIP-Seq_H3396_Human1.66442739
29GATA6_21074721_ChIP-Seq_CACO-2_Human1.65401200
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63427168
31HOXB7_26014856_ChIP-Seq_BT474_Human1.62472335
32GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.62350682
33CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.62042330
34PHF8_20622853_ChIP-Seq_HELA_Human1.61790590
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.59503142
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58995795
37MYC_18940864_ChIP-ChIP_HL60_Human1.58589807
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55778336
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52604221
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.52330156
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.47686000
42RNF2_27304074_Chip-Seq_NSC_Mouse1.45040598
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39821627
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38666693
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38666693
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38371943
47CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.35824144
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.35157503
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34273380
50FOXH1_21741376_ChIP-Seq_EPCs_Human1.33737276
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32775601
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.30055170
53NFYA_21822215_ChIP-Seq_K562_Human1.30041976
54* E2F1_20622854_ChIP-Seq_HELA_Human1.29941872
55* FOXH1_21741376_ChIP-Seq_ESCs_Human1.29417471
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29148725
57CTCF_20526341_ChIP-Seq_ESCs_Human1.25905579
58NCOR_22424771_ChIP-Seq_293T_Human1.22290550
59NANOG_19829295_ChIP-Seq_ESCs_Human1.22061957
60SOX2_19829295_ChIP-Seq_ESCs_Human1.22061957
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20568699
62* MYC_19829295_ChIP-Seq_ESCs_Human1.20212939
63VDR_23849224_ChIP-Seq_CD4+_Human1.18444621
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17688073
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15304099
66REST_21632747_ChIP-Seq_MESCs_Mouse1.15078489
67SOX2_21211035_ChIP-Seq_LN229_Human1.12742569
68BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.12088176
69VDR_22108803_ChIP-Seq_LS180_Human1.10974438
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10016225
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09766584
72* PHF8_20622854_ChIP-Seq_HELA_Human1.09641423
73GATA3_26560356_Chip-Seq_TH2_Human1.08335960
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07644180
75* P53_21459846_ChIP-Seq_SAOS-2_Human1.07013559
76TCF4_23295773_ChIP-Seq_U87_Human1.06085982
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05821881
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02900597
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02849783
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.01960143
81OCT4_20526341_ChIP-Seq_ESCs_Human1.01845485
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00624934
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00306793
84SMAD4_21741376_ChIP-Seq_EPCs_Human0.98181775
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96949396
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93718651
87AR_20517297_ChIP-Seq_VCAP_Human0.90648495
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89667132
89TAF2_19829295_ChIP-Seq_ESCs_Human0.89081518
90OCT4_19829295_ChIP-Seq_ESCs_Human0.88145920
91STAT3_23295773_ChIP-Seq_U87_Human0.87172078
92OCT1_27270436_Chip-Seq_PROSTATE_Human0.86458490
93BCOR_27268052_Chip-Seq_Bcells_Human0.85600676
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85234190
95SMAD4_21799915_ChIP-Seq_A2780_Human0.84557212
96LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84112411
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83192236
98CBX2_22325352_ChIP-Seq_293T-Rex_Human0.79570813
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79537247
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.79157091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.08144443
2MP0001986_abnormal_taste_sensitivity5.11369717
3MP0005423_abnormal_somatic_nervous4.48802591
4MP0003718_maternal_effect3.81841380
5MP0004147_increased_porphyrin_level3.75989423
6MP0006292_abnormal_olfactory_placode3.52012605
7MP0005167_abnormal_blood-brain_barrier3.03959172
8MP0008877_abnormal_DNA_methylation2.76270483
9MP0001348_abnormal_lacrimal_gland2.50253503
10MP0003806_abnormal_nucleotide_metabolis2.45828238
11MP0003693_abnormal_embryo_hatching2.45564446
12MP0002160_abnormal_reproductive_system2.39889321
13MP0002254_reproductive_system_inflammat2.32192055
14MP0005645_abnormal_hypothalamus_physiol2.27561762
15MP0004043_abnormal_pH_regulation2.27117773
16MP0005410_abnormal_fertilization2.26135908
17MP0002735_abnormal_chemical_nociception2.23886778
18MP0002127_abnormal_cardiovascular_syste2.07014643
19MP0009840_abnormal_foam_cell2.06311157
20MP0003195_calcinosis2.05784728
21MP0009379_abnormal_foot_pigmentation1.83989206
22MP0005360_urolithiasis1.83924722
23MP0008872_abnormal_physiological_respon1.83468396
24MP0005389_reproductive_system_phenotype1.78869141
25MP0002138_abnormal_hepatobiliary_system1.72861330
26MP0005647_abnormal_sex_gland1.65012734
27MP0003890_abnormal_embryonic-extraembry1.62855667
28MP0002837_dystrophic_cardiac_calcinosis1.61619244
29MP0010307_abnormal_tumor_latency1.59989444
30MP0002210_abnormal_sex_determination1.58053206
31MP0001929_abnormal_gametogenesis1.47014601
32MP0001919_abnormal_reproductive_system1.43284627
33MP0003136_yellow_coat_color1.38301416
34MP0006276_abnormal_autonomic_nervous1.29166926
35MP0005395_other_phenotype1.29040098
36MP0005085_abnormal_gallbladder_physiolo1.27217253
37MP0005551_abnormal_eye_electrophysiolog1.26266380
38MP0008875_abnormal_xenobiotic_pharmacok1.22311889
39MP0009333_abnormal_splenocyte_physiolog1.18206780
40MP0003698_abnormal_male_reproductive1.16842735
41MP0002139_abnormal_hepatobiliary_system1.15323516
42MP0010030_abnormal_orbit_morphology1.14523397
43MP0001440_abnormal_grooming_behavior1.11839574
44MP0000049_abnormal_middle_ear1.11704570
45MP0004084_abnormal_cardiac_muscle1.07265445
46MP0001849_ear_inflammation1.03609550
47MP0003137_abnormal_impulse_conducting1.02268405
48MP0005365_abnormal_bile_salt0.99432283
49MP0010329_abnormal_lipoprotein_level0.99194369
50MP0008775_abnormal_heart_ventricle0.98508003
51MP0008058_abnormal_DNA_repair0.98386276
52MP0002277_abnormal_respiratory_mucosa0.97296677
53MP0003111_abnormal_nucleus_morphology0.96522181
54MP0004957_abnormal_blastocyst_morpholog0.95951842
55MP0003329_amyloid_beta_deposits0.93020502
56MP0001346_abnormal_lacrimal_gland0.92627061
57MP0002163_abnormal_gland_morphology0.91806937
58MP0000653_abnormal_sex_gland0.91305779
59MP0002161_abnormal_fertility/fecundity0.89514737
60MP0009697_abnormal_copulation0.86537842
61MP0003950_abnormal_plasma_membrane0.86205524
62MP0002733_abnormal_thermal_nociception0.86172449
63MP0001145_abnormal_male_reproductive0.83440654
64MP0004233_abnormal_muscle_weight0.81024598
65MP0004142_abnormal_muscle_tone0.80493448
66MP0005394_taste/olfaction_phenotype0.80288750
67MP0005499_abnormal_olfactory_system0.80288750
68MP0003119_abnormal_digestive_system0.77604280
69MP0008057_abnormal_DNA_replication0.77526231
70MP0001664_abnormal_digestion0.75722098
71MP0010368_abnormal_lymphatic_system0.75271286
72MP0006036_abnormal_mitochondrial_physio0.75220037
73MP0004130_abnormal_muscle_cell0.75191837
74MP0004215_abnormal_myocardial_fiber0.74650641
75MP0002102_abnormal_ear_morphology0.74583728
76MP0009745_abnormal_behavioral_response0.73117327
77MP0002557_abnormal_social/conspecific_i0.72588544
78MP0000427_abnormal_hair_cycle0.72011370
79MP0003699_abnormal_female_reproductive0.71673399
80MP0002734_abnormal_mechanical_nocicepti0.71365888
81MP0005646_abnormal_pituitary_gland0.71024895
82MP0004858_abnormal_nervous_system0.70957591
83MP0004019_abnormal_vitamin_homeostasis0.70742239
84MP0000372_irregular_coat_pigmentation0.70167371
85MP0005266_abnormal_metabolism0.69129944
86MP0003186_abnormal_redox_activity0.67938890
87MP0005379_endocrine/exocrine_gland_phen0.67674140
88MP0003077_abnormal_cell_cycle0.66562138
89MP0004924_abnormal_behavior0.64797876
90MP0005386_behavior/neurological_phenoty0.64797876
91MP0003252_abnormal_bile_duct0.63449209
92MP0001970_abnormal_pain_threshold0.62273785
93MP0008995_early_reproductive_senescence0.61144287
94MP0000230_abnormal_systemic_arterial0.60499769
95MP0001286_abnormal_eye_development0.60218195
96MP0001501_abnormal_sleep_pattern0.59440578
97MP0002272_abnormal_nervous_system0.58941377
98MP0002234_abnormal_pharynx_morphology0.58337134
99MP0001119_abnormal_female_reproductive0.56823959
100MP0001672_abnormal_embryogenesis/_devel0.54278853

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)6.99149808
2Microretrognathia (HP:0000308)5.15292875
3Aplasia/Hypoplasia of the fovea (HP:0008060)4.69316293
4Hypoplasia of the fovea (HP:0007750)4.69316293
5Myokymia (HP:0002411)4.64665181
6Aplasia/Hypoplasia of the sternum (HP:0006714)4.20076417
7Male infertility (HP:0003251)3.80587123
8Conjugated hyperbilirubinemia (HP:0002908)3.80017109
9Aplasia/Hypoplasia involving the musculature (HP:0001460)3.67422890
10Unilateral renal agenesis (HP:0000122)3.58578053
11Type II lissencephaly (HP:0007260)3.56319211
12Patellar aplasia (HP:0006443)3.55593783
13Abnormality of the fovea (HP:0000493)3.53272258
14Aplasia/Hypoplasia of the patella (HP:0006498)3.39458302
15Fused cervical vertebrae (HP:0002949)3.37020678
16Inability to walk (HP:0002540)3.35408166
17Bilateral microphthalmos (HP:0007633)3.34599965
18Congenital stationary night blindness (HP:0007642)3.33691889
19Long foot (HP:0001833)3.31518931
20Progressive inability to walk (HP:0002505)3.28347080
21Lissencephaly (HP:0001339)3.24974871
22Diastasis recti (HP:0001540)3.09505483
23Carpal bone hypoplasia (HP:0001498)3.03123763
24Attenuation of retinal blood vessels (HP:0007843)2.96980233
25Aplasia/hypoplasia of the uterus (HP:0008684)2.94820553
26Abnormality of the clitoris (HP:0000056)2.92586348
27Aplasia/Hypoplasia of the macula (HP:0008059)2.87854264
28Hip dysplasia (HP:0001385)2.82582722
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.82093247
30Large eyes (HP:0001090)2.77414925
31Pendular nystagmus (HP:0012043)2.74687836
32Genu varum (HP:0002970)2.73968766
33Female pseudohermaphroditism (HP:0010458)2.73215171
34Patent foramen ovale (HP:0001655)2.71297077
35Decreased central vision (HP:0007663)2.70332967
36Molar tooth sign on MRI (HP:0002419)2.69591430
37Abnormality of midbrain morphology (HP:0002418)2.69591430
38Aplasia/Hypoplasia affecting the retina (HP:0008061)2.68928965
39Slender long bone (HP:0003100)2.66355478
40Concave nail (HP:0001598)2.65363388
41Poor speech (HP:0002465)2.61166981
42Hypoplasia of the uterus (HP:0000013)2.57691702
43Anterior segment dysgenesis (HP:0007700)2.49632496
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46912444
45Abnormality of the aortic arch (HP:0012303)2.44436743
46Cerebellar dysplasia (HP:0007033)2.41405826
47Depressed nasal tip (HP:0000437)2.38465992
48Posterior subcapsular cataract (HP:0007787)2.37601568
49Scrotal hypoplasia (HP:0000046)2.36702728
50Abnormal rod and cone electroretinograms (HP:0008323)2.32773786
51Nasal speech (HP:0001611)2.32569932
52Widely patent fontanelles and sutures (HP:0004492)2.29813127
53Pancreatic cysts (HP:0001737)2.26229130
54Constricted visual fields (HP:0001133)2.24724532
55Absent septum pellucidum (HP:0001331)2.13942041
56Abnormality of the septum pellucidum (HP:0007375)2.12895598
57Partial agenesis of the corpus callosum (HP:0001338)2.11740054
58Short tibia (HP:0005736)2.11528805
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.09117567
60Abnormal respiratory epithelium morphology (HP:0012253)2.07660333
61Abnormal respiratory motile cilium morphology (HP:0005938)2.07660333
62Abnormality of the pons (HP:0007361)2.06422029
63Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.05486885
64Abnormal pancreas size (HP:0012094)2.04114705
65Breast aplasia (HP:0100783)2.03141647
66Bony spicule pigmentary retinopathy (HP:0007737)2.01429232
67Hyperventilation (HP:0002883)2.01236202
68Birth length less than 3rd percentile (HP:0003561)10.7697629
69Nephronophthisis (HP:0000090)1.98164999
70Abnormal ciliary motility (HP:0012262)1.93664939
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93632959
72Midline defect of the nose (HP:0004122)1.93393996
73Impulsivity (HP:0100710)1.91768335
74Protruding tongue (HP:0010808)1.91721816
75Vertebral fusion (HP:0002948)1.91634104
76Atresia of the external auditory canal (HP:0000413)1.90190174
77Aplasia cutis congenita (HP:0001057)1.88665374
78Bulbous nose (HP:0000414)1.86013553
79Microtia (HP:0008551)1.85951197
80Retinal dysplasia (HP:0007973)1.85405595
81CNS hypomyelination (HP:0003429)1.84213764
82Aplasia/Hypoplasia of the breasts (HP:0010311)1.81139647
83Severe muscular hypotonia (HP:0006829)1.81127886
84Infertility (HP:0000789)1.80851639
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77472957
86Abnormality of the right ventricle (HP:0001707)1.76613966
87Malnutrition (HP:0004395)1.73980196
88Abnormality of glutamine family amino acid metabolism (HP:0010902)1.73333945
89Abnormality of the vitreous humor (HP:0004327)1.71755696
90Widely spaced teeth (HP:0000687)1.70310614
913-Methylglutaconic aciduria (HP:0003535)1.69894749
92Double outlet right ventricle (HP:0001719)1.69543631
93Congenital malformation of the right heart (HP:0011723)1.69543631
94Rhinitis (HP:0012384)1.69290056
95Poor head control (HP:0002421)1.68717182
96Abnormality of the renal collecting system (HP:0004742)1.66762242
97Duplicated collecting system (HP:0000081)1.64437541
98Hypoplasia of the maxilla (HP:0000327)1.64176503
99Scotoma (HP:0000575)1.61749914
100Coxa vara (HP:0002812)1.61578316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.92763414
2BMPR1B4.59516175
3DAPK24.10062556
4NEK23.22446559
5PINK12.88284296
6RIPK42.85475242
7TLK12.79890463
8ZAK2.65789958
9SIK22.41336097
10CASK2.30312367
11TAOK32.20366679
12TGFBR12.18679735
13MELK2.03861085
14BMPR21.99631240
15MAP3K71.96442864
16CDK191.95756179
17CAMKK11.86772798
18WNK31.84930616
19NME11.82335053
20SRPK11.70472616
21BUB11.64983988
22TRIM281.64519036
23ADRBK21.57913068
24BRSK21.45086803
25TESK21.41725358
26PLK11.40461202
27STK38L1.38248900
28LATS21.37056569
29NUAK11.35671393
30MARK31.20634088
31CAMK11.20101902
32TIE11.15287053
33PAK61.13877869
34CAMK41.10942637
35BRSK11.01553658
36NEK60.99112396
37ADRBK10.89586617
38PLK30.87172254
39STK30.85992065
40BMX0.85848017
41PRKCI0.85044556
42PTK2B0.82674346
43STK380.81901160
44STK110.80483935
45GRK10.79429042
46STK160.78559256
47WNK40.76727848
48AURKA0.75243659
49TNIK0.73891821
50PRKAA20.72732603
51CAMK1D0.67569590
52PLK40.67465078
53RPS6KA60.63245853
54CHEK20.62834031
55FRK0.62317489
56AURKB0.61303649
57CAMKK20.61124293
58MAPK130.60817567
59NEK90.59844165
60CAMK2A0.59621803
61PRKD20.58459140
62WNK10.57869506
63MAP2K10.56364369
64SIK30.56187977
65PRKAA10.54095958
66PRKCG0.51684860
67MAP3K40.51223695
68MUSK0.50647684
69CSNK1A10.50378822
70MAP2K60.48323181
71CDK70.48255477
72ATR0.46999854
73CDK30.46688694
74PKN10.46553489
75CSNK2A10.45773180
76GSK3A0.44743329
77ERBB20.44444458
78WEE10.44419461
79MAPKAPK30.43560574
80PRKG20.41854958
81PDK20.41790843
82MET0.40081241
83LATS10.39533234
84MAP4K20.38897371
85CSNK1E0.36157139
86TTK0.35564878
87PIM10.34796790
88PRKCE0.32897870
89OXSR10.32042939
90CDK10.31769887
91CHEK10.31256822
92PAK20.30937591
93VRK10.29548297
94PRKCZ0.29415243
95DYRK30.28915949
96PNCK0.28320942
97PRKG10.27835681
98PRKACG0.27572092
99NTRK30.27438789
100CDK90.25171187

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.25021734
2Regulation of autophagy_Homo sapiens_hsa041403.50458372
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24551367
4Olfactory transduction_Homo sapiens_hsa047403.04625987
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.87806706
6ABC transporters_Homo sapiens_hsa020102.40620766
7Caffeine metabolism_Homo sapiens_hsa002322.31418310
8Linoleic acid metabolism_Homo sapiens_hsa005912.30126944
9Cell cycle_Homo sapiens_hsa041101.95888007
10Arginine and proline metabolism_Homo sapiens_hsa003301.95839897
11RNA polymerase_Homo sapiens_hsa030201.89606111
12Arginine biosynthesis_Homo sapiens_hsa002201.88597027
13Selenocompound metabolism_Homo sapiens_hsa004501.87896878
14mRNA surveillance pathway_Homo sapiens_hsa030151.73477161
15p53 signaling pathway_Homo sapiens_hsa041151.72439495
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65948379
17RNA transport_Homo sapiens_hsa030131.63552372
18Fatty acid biosynthesis_Homo sapiens_hsa000611.62431371
19Nitrogen metabolism_Homo sapiens_hsa009101.61882974
20Taste transduction_Homo sapiens_hsa047421.54954561
21Ribosome_Homo sapiens_hsa030101.44910347
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.44647011
23Ovarian steroidogenesis_Homo sapiens_hsa049131.43858674
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38298439
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37921605
26Fatty acid elongation_Homo sapiens_hsa000621.35044518
27Insulin secretion_Homo sapiens_hsa049111.34259704
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.29587145
29RNA degradation_Homo sapiens_hsa030181.28785159
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26624808
31Histidine metabolism_Homo sapiens_hsa003401.26360752
32Phototransduction_Homo sapiens_hsa047441.23390908
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23123911
34Chemical carcinogenesis_Homo sapiens_hsa052041.22199979
35Fanconi anemia pathway_Homo sapiens_hsa034601.19389923
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15418901
37Serotonergic synapse_Homo sapiens_hsa047261.08755881
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03179358
39Nicotine addiction_Homo sapiens_hsa050331.02846118
40Retinol metabolism_Homo sapiens_hsa008301.02294955
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.98595015
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95767305
43Spliceosome_Homo sapiens_hsa030400.95392736
44Sulfur relay system_Homo sapiens_hsa041220.93843527
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93374957
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93373626
47GABAergic synapse_Homo sapiens_hsa047270.92184832
48Butanoate metabolism_Homo sapiens_hsa006500.91455706
49Arachidonic acid metabolism_Homo sapiens_hsa005900.91239098
50Long-term depression_Homo sapiens_hsa047300.90897765
51Circadian rhythm_Homo sapiens_hsa047100.90104837
52Bile secretion_Homo sapiens_hsa049760.88586596
53TGF-beta signaling pathway_Homo sapiens_hsa043500.87726424
54Dorso-ventral axis formation_Homo sapiens_hsa043200.86691036
55Tyrosine metabolism_Homo sapiens_hsa003500.85592071
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.83286192
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79595889
58Ether lipid metabolism_Homo sapiens_hsa005650.78991935
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78060049
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77012388
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.77009438
62Salivary secretion_Homo sapiens_hsa049700.74909502
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74300497
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.73838228
65Calcium signaling pathway_Homo sapiens_hsa040200.72779743
66Morphine addiction_Homo sapiens_hsa050320.72005633
67Pyrimidine metabolism_Homo sapiens_hsa002400.70922550
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70356793
69Circadian entrainment_Homo sapiens_hsa047130.69188118
70Oocyte meiosis_Homo sapiens_hsa041140.68216415
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68160945
72Glutamatergic synapse_Homo sapiens_hsa047240.67686909
73African trypanosomiasis_Homo sapiens_hsa051430.66246812
74Vitamin digestion and absorption_Homo sapiens_hsa049770.65963210
75beta-Alanine metabolism_Homo sapiens_hsa004100.65872536
76Homologous recombination_Homo sapiens_hsa034400.63562699
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61453035
78Sulfur metabolism_Homo sapiens_hsa009200.59510226
79Gastric acid secretion_Homo sapiens_hsa049710.59318410
80Nucleotide excision repair_Homo sapiens_hsa034200.57340478
81Cardiac muscle contraction_Homo sapiens_hsa042600.57326854
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.49822452
83Thyroid hormone synthesis_Homo sapiens_hsa049180.48880391
84Folate biosynthesis_Homo sapiens_hsa007900.48169283
85Purine metabolism_Homo sapiens_hsa002300.47670104
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47047279
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46878830
88Mineral absorption_Homo sapiens_hsa049780.46503088
89Amphetamine addiction_Homo sapiens_hsa050310.45854903
90Tryptophan metabolism_Homo sapiens_hsa003800.44008217
91Oxytocin signaling pathway_Homo sapiens_hsa049210.43095256
92Glutathione metabolism_Homo sapiens_hsa004800.40714538
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40372332
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40227663
95Inositol phosphate metabolism_Homo sapiens_hsa005620.39887469
96Choline metabolism in cancer_Homo sapiens_hsa052310.38689774
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37069895
98Glycerolipid metabolism_Homo sapiens_hsa005610.36752563
99Hippo signaling pathway_Homo sapiens_hsa043900.36214943
100Fat digestion and absorption_Homo sapiens_hsa049750.35697899

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »