ZNF729

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.83804922
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.81729905
3regulation of meiosis I (GO:0060631)4.66327600
4regulation of retinoic acid receptor signaling pathway (GO:0048385)4.50311945
5male meiosis I (GO:0007141)4.40098400
6peptidyl-histidine modification (GO:0018202)4.23198924
7synapsis (GO:0007129)4.16780028
8protein K6-linked ubiquitination (GO:0085020)4.08099968
9cranial suture morphogenesis (GO:0060363)3.86718867
10outer ear morphogenesis (GO:0042473)3.86705808
11artery development (GO:0060840)3.77705065
12polyamine biosynthetic process (GO:0006596)3.68238105
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.55424570
14somatic hypermutation of immunoglobulin genes (GO:0016446)3.55424570
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53611349
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53611349
17male meiosis (GO:0007140)3.52946109
18meiosis I (GO:0007127)3.52111337
19lung-associated mesenchyme development (GO:0060484)3.50917590
20nodal signaling pathway (GO:0038092)3.49999666
21mitochondrial RNA metabolic process (GO:0000959)3.47665283
22regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.44885703
23regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.44885703
24somite rostral/caudal axis specification (GO:0032525)3.39945538
25proteasome assembly (GO:0043248)3.34346890
26regulation of gene silencing by RNA (GO:0060966)3.34346275
27regulation of posttranscriptional gene silencing (GO:0060147)3.34346275
28regulation of gene silencing by miRNA (GO:0060964)3.34346275
29keratinocyte development (GO:0003334)3.30620834
30protein-cofactor linkage (GO:0018065)3.29891456
31ubiquinone biosynthetic process (GO:0006744)3.24746569
32mesenchymal cell proliferation (GO:0010463)3.24102641
33respiratory chain complex IV assembly (GO:0008535)3.13653767
34regulation of DNA methylation (GO:0044030)3.12842729
35lactate metabolic process (GO:0006089)3.10954333
36cell fate commitment involved in formation of primary germ layer (GO:0060795)3.10176039
37ubiquinone metabolic process (GO:0006743)3.10156299
38DNA methylation involved in gamete generation (GO:0043046)3.07303113
39single strand break repair (GO:0000012)3.03417105
40reflex (GO:0060004)3.03116194
41regulation of mitochondrial translation (GO:0070129)2.97827186
42meiotic nuclear division (GO:0007126)2.92052255
43chromosome organization involved in meiosis (GO:0070192)2.90756197
44intracellular protein transmembrane import (GO:0044743)2.86255862
45chaperone-mediated protein transport (GO:0072321)2.85799816
46regulation of neurotransmitter uptake (GO:0051580)2.83306749
47maturation of 5.8S rRNA (GO:0000460)2.79691980
48chromatin remodeling at centromere (GO:0031055)2.79610793
49histone exchange (GO:0043486)2.79438446
50regulation of gene expression by genetic imprinting (GO:0006349)2.79212766
51regulation of nuclear cell cycle DNA replication (GO:0033262)2.77784795
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75114321
53establishment of protein localization to mitochondrial membrane (GO:0090151)2.74242644
54rRNA modification (GO:0000154)2.73702426
55cellular biogenic amine biosynthetic process (GO:0042401)2.72724828
56intracellular protein transmembrane transport (GO:0065002)2.72481488
57negative regulation of gene silencing (GO:0060969)2.71861029
58regulation of centriole replication (GO:0046599)2.71735761
59primitive streak formation (GO:0090009)2.69704202
60pseudouridine synthesis (GO:0001522)2.69644443
61polyamine metabolic process (GO:0006595)2.67059216
62CENP-A containing nucleosome assembly (GO:0034080)2.66853153
63reciprocal DNA recombination (GO:0035825)2.64958293
64reciprocal meiotic recombination (GO:0007131)2.64958293
65L-alpha-amino acid transmembrane transport (GO:1902475)2.64698532
66meiotic chromosome segregation (GO:0045132)2.63162420
67meiotic cell cycle process (GO:1903046)2.60244043
68transcription from mitochondrial promoter (GO:0006390)2.59238090
69blastocyst development (GO:0001824)2.59028736
70negative regulation of meiosis (GO:0045835)2.55265567
71amine biosynthetic process (GO:0009309)2.54583427
72mitochondrion morphogenesis (GO:0070584)2.53879099
73quinone biosynthetic process (GO:1901663)2.52433060
74water-soluble vitamin biosynthetic process (GO:0042364)2.51768903
75positive regulation of histone H3-K4 methylation (GO:0051571)2.51153066
76DNA double-strand break processing (GO:0000729)2.50642313
77cochlea development (GO:0090102)2.50322236
78fatty acid homeostasis (GO:0055089)2.50281798
79regulation of double-strand break repair via homologous recombination (GO:0010569)2.47815440
80negative regulation of sodium ion transport (GO:0010766)2.47024784
81regulation of mesoderm development (GO:2000380)2.45762148
82mitochondrial respiratory chain complex assembly (GO:0033108)2.44247929
83regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.43981810
84embryonic pattern specification (GO:0009880)2.43859684
85regulation of cellular respiration (GO:0043457)2.43462191
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42177988
87regulation of helicase activity (GO:0051095)2.41946967
88recombinational repair (GO:0000725)2.41327863
89tRNA metabolic process (GO:0006399)2.41062041
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.40123630
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.40123630
92NADH dehydrogenase complex assembly (GO:0010257)2.40123630
93gene silencing by RNA (GO:0031047)2.39998001
94spliceosomal complex assembly (GO:0000245)2.39009585
95DNA alkylation (GO:0006305)2.38865127
96DNA methylation (GO:0006306)2.38865127
97telomere maintenance via semi-conservative replication (GO:0032201)2.38654168
98anterior/posterior axis specification, embryo (GO:0008595)2.36802309
99sister chromatid cohesion (GO:0007062)2.36686483
100negative regulation of epidermal cell differentiation (GO:0045605)2.34646113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.45630560
2ZNF274_21170338_ChIP-Seq_K562_Hela4.16648444
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76971034
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.30010433
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.99124994
6E2F7_22180533_ChIP-Seq_HELA_Human2.77024363
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62142299
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.61337074
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52682050
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42605209
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42104127
12VDR_22108803_ChIP-Seq_LS180_Human2.39280201
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37913483
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.34571742
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.33497192
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27544989
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.21008773
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15118225
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.13727700
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11867290
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02962446
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87681261
23ELK1_19687146_ChIP-ChIP_HELA_Human1.85478903
24IGF1R_20145208_ChIP-Seq_DFB_Human1.80755241
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79691449
26VDR_23849224_ChIP-Seq_CD4+_Human1.78610939
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71230796
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71230796
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71230796
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66276609
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64208416
32FOXP3_21729870_ChIP-Seq_TREG_Human1.61164716
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58885422
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54965289
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54359402
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.52777106
37MYC_18940864_ChIP-ChIP_HL60_Human1.51355455
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49567485
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49156023
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46126038
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43430791
42TP53_22573176_ChIP-Seq_HFKS_Human1.43385514
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40286981
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.39930531
45TTF2_22483619_ChIP-Seq_HELA_Human1.38539068
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36595519
47GABP_19822575_ChIP-Seq_HepG2_Human1.35340122
48DCP1A_22483619_ChIP-Seq_HELA_Human1.34900560
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32298967
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31111586
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28149226
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.26746144
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22141192
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21533873
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.20571817
56EWS_26573619_Chip-Seq_HEK293_Human1.19077427
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17381138
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16740513
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16072661
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15686068
61HOXB7_26014856_ChIP-Seq_BT474_Human1.14643567
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13669070
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11564529
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10115792
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08898822
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.08898822
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.07557793
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04475973
69P300_19829295_ChIP-Seq_ESCs_Human1.01378301
70NANOG_19829295_ChIP-Seq_ESCs_Human1.01062938
71SOX2_19829295_ChIP-Seq_ESCs_Human1.01062938
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00500889
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00167297
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00008024
75KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99166847
76TAF15_26573619_Chip-Seq_HEK293_Human0.98075923
77ERA_21632823_ChIP-Seq_H3396_Human0.97286495
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96600490
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96133630
80POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96114550
81KDM5A_27292631_Chip-Seq_BREAST_Human0.95284020
82IRF1_19129219_ChIP-ChIP_H3396_Human0.94571636
83BCAT_22108803_ChIP-Seq_LS180_Human0.94353632
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93641780
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92416311
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92251884
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90135448
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89262085
89GBX2_23144817_ChIP-Seq_PC3_Human0.89249786
90HTT_18923047_ChIP-ChIP_STHdh_Human0.89057251
91TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88594337
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87444093
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87323835
94AR_20517297_ChIP-Seq_VCAP_Human0.86305818
95FUS_26573619_Chip-Seq_HEK293_Human0.83038266
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82859101
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.81216326
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80712483
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80474486
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.80455003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.06902848
2MP0003890_abnormal_embryonic-extraembry3.76351174
3MP0003718_maternal_effect3.15151560
4MP0008058_abnormal_DNA_repair3.01561471
5MP0003787_abnormal_imprinting2.96973281
6MP0005451_abnormal_body_composition2.91491826
7MP0002254_reproductive_system_inflammat2.48331642
8MP0010094_abnormal_chromosome_stability2.47263585
9MP0003693_abnormal_embryo_hatching2.42932549
10MP0008057_abnormal_DNA_replication2.40082784
11MP0006292_abnormal_olfactory_placode2.27928081
12MP0002837_dystrophic_cardiac_calcinosis2.25953173
13MP0004957_abnormal_blastocyst_morpholog2.22357408
14MP0001986_abnormal_taste_sensitivity2.21257759
15MP0009046_muscle_twitch2.17396734
16MP0008872_abnormal_physiological_respon2.06943749
17MP0005379_endocrine/exocrine_gland_phen1.95885795
18MP0004133_heterotaxia1.94575323
19MP0008995_early_reproductive_senescence1.74579100
20MP0004147_increased_porphyrin_level1.70232382
21MP0003806_abnormal_nucleotide_metabolis1.68905434
22MP0002163_abnormal_gland_morphology1.65885439
23MP0003119_abnormal_digestive_system1.63590244
24MP0002160_abnormal_reproductive_system1.63573828
25MP0002909_abnormal_adrenal_gland1.61996102
26MP0010307_abnormal_tumor_latency1.61686156
27MP0002102_abnormal_ear_morphology1.60805121
28MP0002210_abnormal_sex_determination1.60447845
29MP0001929_abnormal_gametogenesis1.53748537
30MP0000566_synostosis1.50153651
31MP0003077_abnormal_cell_cycle1.47182681
32MP0003938_abnormal_ear_development1.46228720
33MP0008932_abnormal_embryonic_tissue1.39520235
34MP0009780_abnormal_chondrocyte_physiolo1.33976318
35MP0002084_abnormal_developmental_patter1.33843686
36MP0003121_genomic_imprinting1.33744741
37MP0003195_calcinosis1.31817071
38MP0002938_white_spotting1.30942175
39MP0003111_abnormal_nucleus_morphology1.29645175
40MP0001145_abnormal_male_reproductive1.28921624
41MP0006072_abnormal_retinal_apoptosis1.26839092
42MP0005410_abnormal_fertilization1.23899272
43MP0003698_abnormal_male_reproductive1.23735511
44MP0000049_abnormal_middle_ear1.23682075
45MP0000653_abnormal_sex_gland1.23507987
46MP0003186_abnormal_redox_activity1.23188093
47MP0005551_abnormal_eye_electrophysiolog1.23142187
48MP0000427_abnormal_hair_cycle1.22706946
49MP0000647_abnormal_sebaceous_gland1.17881512
50MP0005389_reproductive_system_phenotype1.17731279
51MP0003567_abnormal_fetal_cardiomyocyte1.13183832
52MP0003646_muscle_fatigue1.10915637
53MP0005646_abnormal_pituitary_gland1.10530581
54MP0003786_premature_aging1.09276049
55MP0006035_abnormal_mitochondrial_morpho1.02874005
56MP0005423_abnormal_somatic_nervous1.02248186
57MP0001529_abnormal_vocalization1.00119942
58MP0005645_abnormal_hypothalamus_physiol0.99872794
59MP0003283_abnormal_digestive_organ0.97853089
60MP0001293_anophthalmia0.96304975
61MP0000462_abnormal_digestive_system0.96009595
62MP0000631_abnormal_neuroendocrine_gland0.93985370
63MP0002876_abnormal_thyroid_physiology0.93864842
64MP0009745_abnormal_behavioral_response0.91378117
65MP0000678_abnormal_parathyroid_gland0.91095746
66MP0002638_abnormal_pupillary_reflex0.90779771
67MP0001968_abnormal_touch/_nociception0.90500091
68MP0005647_abnormal_sex_gland0.89944769
69MP0002111_abnormal_tail_morphology0.89542013
70MP0002085_abnormal_embryonic_tissue0.88848927
71MP0003937_abnormal_limbs/digits/tail_de0.88783391
72MP0006276_abnormal_autonomic_nervous0.88612080
73MP0001905_abnormal_dopamine_level0.88561373
74MP0004270_analgesia0.88467290
75MP0004215_abnormal_myocardial_fiber0.88312458
76MP0002796_impaired_skin_barrier0.87595218
77MP0005395_other_phenotype0.85750262
78MP0002161_abnormal_fertility/fecundity0.85164172
79MP0002751_abnormal_autonomic_nervous0.84551251
80MP0005332_abnormal_amino_acid0.83247920
81MP0001440_abnormal_grooming_behavior0.81547065
82MP0009672_abnormal_birth_weight0.81492931
83MP0002735_abnormal_chemical_nociception0.80812294
84MP0004019_abnormal_vitamin_homeostasis0.79317664
85MP0004885_abnormal_endolymph0.79236635
86MP0003880_abnormal_central_pattern0.77432738
87MP0002736_abnormal_nociception_after0.77202034
88MP0008775_abnormal_heart_ventricle0.77006996
89MP0005075_abnormal_melanosome_morpholog0.76971072
90MP0005380_embryogenesis_phenotype0.75696176
91MP0001672_abnormal_embryogenesis/_devel0.75696176
92MP0001730_embryonic_growth_arrest0.75046165
93MP0008875_abnormal_xenobiotic_pharmacok0.73768817
94MP0001486_abnormal_startle_reflex0.72692581
95MP0008007_abnormal_cellular_replicative0.72669407
96MP0002693_abnormal_pancreas_physiology0.71050913
97MP0005394_taste/olfaction_phenotype0.70463877
98MP0005499_abnormal_olfactory_system0.70463877
99MP0002272_abnormal_nervous_system0.69048416
100MP0008789_abnormal_olfactory_epithelium0.68966329

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.05026939
2Broad distal phalanx of finger (HP:0009836)3.75541437
3Birth length less than 3rd percentile (HP:0003561)3.62389565
411 pairs of ribs (HP:0000878)3.59800706
5Hypoplasia of the fovea (HP:0007750)3.24326989
6Aplasia/Hypoplasia of the fovea (HP:0008060)3.24326989
7Fused cervical vertebrae (HP:0002949)3.17472415
8Pancreatic cysts (HP:0001737)3.16709975
9Pendular nystagmus (HP:0012043)3.01749248
10Chromsome breakage (HP:0040012)2.96650902
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79113292
12Bilateral microphthalmos (HP:0007633)2.77309665
13Hyperglycinemia (HP:0002154)2.69797408
14Large for gestational age (HP:0001520)2.69196405
15Medial flaring of the eyebrow (HP:0010747)2.62120943
16Pancreatic fibrosis (HP:0100732)2.59421740
17Hyperglycinuria (HP:0003108)2.55513793
18Abnormality of midbrain morphology (HP:0002418)2.54176827
19Molar tooth sign on MRI (HP:0002419)2.54176827
20Abnormality of the renal collecting system (HP:0004742)2.49299979
21Abnormality of the fovea (HP:0000493)2.48236151
22Hyperglycemia (HP:0003074)2.47447994
23Ependymoma (HP:0002888)2.46600456
24True hermaphroditism (HP:0010459)2.46299969
25Congenital primary aphakia (HP:0007707)2.36540741
26Duplicated collecting system (HP:0000081)2.35374523
27Cystic liver disease (HP:0006706)2.34857627
28Gait imbalance (HP:0002141)2.33509438
29Aplasia/hypoplasia of the uterus (HP:0008684)2.28145617
30Nephrogenic diabetes insipidus (HP:0009806)2.26647269
31Acute necrotizing encephalopathy (HP:0006965)2.26387855
32Abdominal situs inversus (HP:0003363)2.25666180
33Abnormality of abdominal situs (HP:0011620)2.25666180
34Increased CSF lactate (HP:0002490)2.23580348
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23179779
36Abnormality of alanine metabolism (HP:0010916)2.23179779
37Hyperalaninemia (HP:0003348)2.23179779
38Increased hepatocellular lipid droplets (HP:0006565)2.20737990
39Progressive cerebellar ataxia (HP:0002073)2.18904113
40Hyperinsulinemic hypoglycemia (HP:0000825)2.09537120
41Methylmalonic acidemia (HP:0002912)2.08605366
42Acute encephalopathy (HP:0006846)2.08396491
43Abnormality of serine family amino acid metabolism (HP:0010894)2.07585789
44Abnormality of glycine metabolism (HP:0010895)2.07585789
45Hypoglycemic seizures (HP:0002173)2.06352360
46Meckel diverticulum (HP:0002245)2.05301529
47Stenosis of the external auditory canal (HP:0000402)2.04424422
48Abnormality of the ileum (HP:0001549)2.02152024
49Vaginal atresia (HP:0000148)2.02099933
50Progressive macrocephaly (HP:0004481)2.02073526
51Osteomalacia (HP:0002749)2.01397475
52Spinal cord compression (HP:0002176)1.98866053
53Genital tract atresia (HP:0001827)1.98193633
54Increased serum lactate (HP:0002151)1.97896380
55Methylmalonic aciduria (HP:0012120)1.97815971
56Breast carcinoma (HP:0003002)1.97190596
57Lipid accumulation in hepatocytes (HP:0006561)1.96647171
58Aplasia/Hypoplasia of the macula (HP:0008059)1.95348120
59Inability to walk (HP:0002540)1.95123183
60Missing ribs (HP:0000921)1.95037482
61Short nail (HP:0001799)1.94600183
62Furrowed tongue (HP:0000221)1.94104899
63Nephronophthisis (HP:0000090)1.91356108
64Microvesicular hepatic steatosis (HP:0001414)1.87815534
65Abnormal mitochondria in muscle tissue (HP:0008316)1.84392633
66Progressive inability to walk (HP:0002505)1.83883120
67Glioma (HP:0009733)1.82694813
68Absent radius (HP:0003974)1.82540400
69Female pseudohermaphroditism (HP:0010458)1.82533856
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81138945
71Patellar aplasia (HP:0006443)1.81102285
72Male pseudohermaphroditism (HP:0000037)1.79148412
73Aplasia/Hypoplasia affecting the retina (HP:0008061)1.77153535
74Hypoplasia of the uterus (HP:0000013)1.76674013
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.76311424
76Mitochondrial inheritance (HP:0001427)1.76234717
77Severe muscular hypotonia (HP:0006829)1.76105503
78Aplasia involving forearm bones (HP:0009822)1.75804611
79Absent forearm bone (HP:0003953)1.75804611
80Cleft eyelid (HP:0000625)1.72012305
81Hypomagnesemia (HP:0002917)1.70834278
82Intestinal atresia (HP:0011100)1.70555975
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.70032466
84Amelogenesis imperfecta (HP:0000705)1.66565740
85Aplasia/Hypoplasia of the patella (HP:0006498)1.65528292
86Poor coordination (HP:0002370)1.65292540
87Delayed gross motor development (HP:0002194)1.65022931
88Brushfield spots (HP:0001088)1.64881725
89Hypoplastic labia majora (HP:0000059)1.63996215
90Small hand (HP:0200055)1.62213385
91Azoospermia (HP:0000027)1.62036997
92Genetic anticipation (HP:0003743)1.58532773
93Abnormality of DNA repair (HP:0003254)1.57209433
94Cerebral hypomyelination (HP:0006808)1.56431485
95Lactic acidosis (HP:0003128)1.56332994
96Short hallux (HP:0010109)1.55316882
97Hypoglycemic coma (HP:0001325)1.54972278
98Occipital encephalocele (HP:0002085)1.54108079
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.53630872
100Triphalangeal thumb (HP:0001199)1.53453946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.82509708
2ZAK3.55022023
3ACVR1B3.33598965
4PHKG22.95592780
5PHKG12.95592780
6WNK32.66944510
7FRK2.58940734
8SRPK12.49118307
9LMTK22.45074506
10MST42.35993822
11PLK42.25168875
12TSSK62.23818204
13GRK12.20476890
14TTK2.15534758
15ADRBK21.98208394
16STK161.89485041
17PLK31.81330683
18BMPR1B1.68914996
19CDK191.66932793
20MKNK21.63094801
21WNK41.59034264
22PINK11.58703083
23FGFR21.57482266
24TRIM281.51570093
25MAP3K41.43667737
26NTRK31.36560875
27MKNK11.36040048
28EIF2AK31.32729022
29OXSR11.27299909
30CDC71.23927915
31CSNK1G11.22462674
32NME11.17705866
33KSR11.17625924
34PLK11.16767659
35PDK21.13448800
36CSNK1G31.12532488
37NEK11.12418044
38PASK1.10165467
39KSR21.09399287
40MAP3K21.09177555
41PAK61.08911218
42BUB11.07851201
43CSNK1G21.05980532
44BRSK21.05019915
45STK41.04144255
46MAP4K21.03958564
47NUAK11.01727323
48TLK10.99526455
49PAK30.96089097
50DYRK20.95906563
51STK38L0.95427967
52TIE10.94293415
53BCR0.92967110
54VRK20.89474546
55ATR0.89214498
56STK390.88318104
57INSRR0.87266881
58MAP2K70.86510738
59CSNK1A1L0.86084134
60WNK10.85525158
61ATM0.81826273
62VRK10.81204859
63EIF2AK10.78395535
64EPHA40.75766638
65CHEK20.75692212
66TGFBR10.74635809
67PNCK0.70921780
68PRKCI0.68846518
69WEE10.66790087
70CASK0.63580759
71NEK20.63273163
72BCKDK0.61998027
73STK30.57755499
74PRKCG0.57577196
75CSNK1E0.56745286
76AURKB0.56716834
77BMX0.53560228
78AKT30.53306753
79AURKA0.50828120
80CHEK10.49205709
81PRKDC0.48747687
82PRKCE0.47200781
83RAF10.45673634
84MAP2K10.45347633
85BRSK10.44883692
86ALK0.44211404
87CSNK2A10.43984715
88PLK20.43674971
89CSNK1A10.41613845
90MUSK0.40848926
91CSNK1D0.39849153
92BRAF0.36581034
93PRKAA10.34372105
94CDK10.34039491
95MAP2K60.33956153
96FER0.33947419
97DYRK30.32144590
98NEK60.31237040
99RPS6KB10.30941343
100MAP3K90.30740859

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.78871615
2Folate biosynthesis_Homo sapiens_hsa007903.42817609
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93697036
4Mismatch repair_Homo sapiens_hsa034302.71986927
5Homologous recombination_Homo sapiens_hsa034402.70911238
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.64055787
7Protein export_Homo sapiens_hsa030602.51954244
8Non-homologous end-joining_Homo sapiens_hsa034502.43597752
9Basal transcription factors_Homo sapiens_hsa030222.31743521
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26379207
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23195912
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.06995815
13DNA replication_Homo sapiens_hsa030302.03295055
14Regulation of autophagy_Homo sapiens_hsa041402.02811254
15Fanconi anemia pathway_Homo sapiens_hsa034602.00426738
16Oxidative phosphorylation_Homo sapiens_hsa001901.97910028
17RNA transport_Homo sapiens_hsa030131.90003830
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77294689
19RNA degradation_Homo sapiens_hsa030181.75896011
20RNA polymerase_Homo sapiens_hsa030201.66147827
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60742079
22Parkinsons disease_Homo sapiens_hsa050121.59475298
23Proteasome_Homo sapiens_hsa030501.56684653
24Nucleotide excision repair_Homo sapiens_hsa034201.56473877
25Propanoate metabolism_Homo sapiens_hsa006401.50172271
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48912530
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.44575917
28Phototransduction_Homo sapiens_hsa047441.41891956
29Peroxisome_Homo sapiens_hsa041461.36109196
30Ribosome_Homo sapiens_hsa030101.30284736
31Fatty acid elongation_Homo sapiens_hsa000621.26242177
32One carbon pool by folate_Homo sapiens_hsa006701.25085389
33Ether lipid metabolism_Homo sapiens_hsa005651.24873269
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24412892
35Base excision repair_Homo sapiens_hsa034101.21278851
36Huntingtons disease_Homo sapiens_hsa050161.20321255
37Butanoate metabolism_Homo sapiens_hsa006501.19240615
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18635422
39mRNA surveillance pathway_Homo sapiens_hsa030151.15117708
40Spliceosome_Homo sapiens_hsa030401.09450249
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06278343
42Steroid biosynthesis_Homo sapiens_hsa001001.04709202
43Pyrimidine metabolism_Homo sapiens_hsa002401.02186650
44Linoleic acid metabolism_Homo sapiens_hsa005910.98178819
45Fat digestion and absorption_Homo sapiens_hsa049750.91555493
46Cell cycle_Homo sapiens_hsa041100.91219613
47Mineral absorption_Homo sapiens_hsa049780.88730804
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87913578
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85457158
50Oocyte meiosis_Homo sapiens_hsa041140.85337033
51Insulin secretion_Homo sapiens_hsa049110.85251805
52p53 signaling pathway_Homo sapiens_hsa041150.85182070
53Glutathione metabolism_Homo sapiens_hsa004800.84313619
54Cardiac muscle contraction_Homo sapiens_hsa042600.84057481
55Purine metabolism_Homo sapiens_hsa002300.83909262
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82953285
57Collecting duct acid secretion_Homo sapiens_hsa049660.82740529
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78772715
59Metabolic pathways_Homo sapiens_hsa011000.74692501
60Alzheimers disease_Homo sapiens_hsa050100.72524183
61Caffeine metabolism_Homo sapiens_hsa002320.68413997
62Nitrogen metabolism_Homo sapiens_hsa009100.66573569
63Sulfur metabolism_Homo sapiens_hsa009200.65564733
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65139121
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65013482
66beta-Alanine metabolism_Homo sapiens_hsa004100.64560843
67ABC transporters_Homo sapiens_hsa020100.63291414
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60863632
69Nicotine addiction_Homo sapiens_hsa050330.60515514
70Olfactory transduction_Homo sapiens_hsa047400.58596699
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57460959
72Hedgehog signaling pathway_Homo sapiens_hsa043400.55295327
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53948568
74Pyruvate metabolism_Homo sapiens_hsa006200.53909545
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53719449
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52481537
77Taste transduction_Homo sapiens_hsa047420.51664688
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50635742
79N-Glycan biosynthesis_Homo sapiens_hsa005100.50151582
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50130567
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46587712
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46128919
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45978212
84Arginine and proline metabolism_Homo sapiens_hsa003300.44556781
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40138991
86Ovarian steroidogenesis_Homo sapiens_hsa049130.39742805
87Retinol metabolism_Homo sapiens_hsa008300.37254237
88Circadian rhythm_Homo sapiens_hsa047100.36375206
89Hippo signaling pathway_Homo sapiens_hsa043900.36015654
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35768546
91Chemical carcinogenesis_Homo sapiens_hsa052040.33185348
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33100643
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31428884
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30052722
95Basal cell carcinoma_Homo sapiens_hsa052170.30037476
96Tryptophan metabolism_Homo sapiens_hsa003800.29293034
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28932976
98TGF-beta signaling pathway_Homo sapiens_hsa043500.28381762
99Arachidonic acid metabolism_Homo sapiens_hsa005900.26283086
100GABAergic synapse_Homo sapiens_hsa047270.25688753

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »