ZNF713

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains C2H2 zinc finger domains. In some individuals, a CGG-repeat expansion from 5-22 repeats to 68-450 repeats has been identified in the first intron of this gene. This mutation is thought to effect the expression of this gene and it has been proposed that it may be associated with Autistic Spectrum Disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.78694547
2fucose catabolic process (GO:0019317)4.06603859
3L-fucose metabolic process (GO:0042354)4.06603859
4L-fucose catabolic process (GO:0042355)4.06603859
5response to pheromone (GO:0019236)3.98756347
6indole-containing compound catabolic process (GO:0042436)3.89047722
7indolalkylamine catabolic process (GO:0046218)3.89047722
8tryptophan catabolic process (GO:0006569)3.89047722
9indolalkylamine metabolic process (GO:0006586)3.84070754
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.82191253
11kynurenine metabolic process (GO:0070189)3.77210883
12negative regulation of telomere maintenance (GO:0032205)3.66546933
13pyrimidine nucleobase catabolic process (GO:0006208)3.57472243
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51216091
15neural tube formation (GO:0001841)3.48166215
16tryptophan metabolic process (GO:0006568)3.35295328
17DNA deamination (GO:0045006)3.32708394
18piRNA metabolic process (GO:0034587)3.29135445
19platelet dense granule organization (GO:0060155)3.25050950
20epithelial cilium movement (GO:0003351)3.24268895
21axoneme assembly (GO:0035082)3.18621798
22detection of light stimulus involved in visual perception (GO:0050908)3.17842777
23detection of light stimulus involved in sensory perception (GO:0050962)3.17842777
24somite development (GO:0061053)3.17722093
25nonmotile primary cilium assembly (GO:0035058)3.17304820
26protein polyglutamylation (GO:0018095)3.16965616
27cellular ketone body metabolic process (GO:0046950)3.16896174
28behavioral response to ethanol (GO:0048149)3.11196541
29nucleobase catabolic process (GO:0046113)3.07789513
30gamma-aminobutyric acid transport (GO:0015812)3.05867479
31cornea development in camera-type eye (GO:0061303)3.04454853
32preassembly of GPI anchor in ER membrane (GO:0016254)3.03803123
33regulation of cilium movement (GO:0003352)3.02727565
34indole-containing compound metabolic process (GO:0042430)2.99310685
35protein-cofactor linkage (GO:0018065)2.98405098
36neuronal action potential (GO:0019228)2.96555153
37protein localization to cilium (GO:0061512)2.94370127
38cilium morphogenesis (GO:0060271)2.92970351
39postsynaptic membrane organization (GO:0001941)2.91423362
40DNA methylation involved in gamete generation (GO:0043046)2.90694691
41regulation of telomere maintenance (GO:0032204)2.87281937
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86756596
43ketone body metabolic process (GO:1902224)2.86650661
44kidney morphogenesis (GO:0060993)2.86363214
45cellular biogenic amine catabolic process (GO:0042402)2.83434524
46amine catabolic process (GO:0009310)2.83434524
47negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82642360
48negative regulation of transcription regulatory region DNA binding (GO:2000678)2.82604725
49synaptic transmission, cholinergic (GO:0007271)2.82121132
50cilium movement (GO:0003341)2.81008336
51water-soluble vitamin biosynthetic process (GO:0042364)2.80277625
52reflex (GO:0060004)2.79079659
53cilium or flagellum-dependent cell motility (GO:0001539)2.78708134
54regulation of action potential (GO:0098900)2.77442636
55positive regulation of oligodendrocyte differentiation (GO:0048714)2.76264654
56protein complex biogenesis (GO:0070271)2.76177529
57spinal cord motor neuron differentiation (GO:0021522)2.75074590
58cilium organization (GO:0044782)2.75025926
59transmission of nerve impulse (GO:0019226)2.73294878
60retinal cone cell development (GO:0046549)2.72793120
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.72296726
62NADH dehydrogenase complex assembly (GO:0010257)2.72296726
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72296726
64sulfation (GO:0051923)2.70436774
65negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69361976
66regulation of hippo signaling (GO:0035330)2.66061152
67cilium assembly (GO:0042384)2.65392242
68photoreceptor cell development (GO:0042461)2.64737566
69presynaptic membrane assembly (GO:0097105)2.63944966
70photoreceptor cell maintenance (GO:0045494)2.60977265
71mannosylation (GO:0097502)2.60344174
72inner ear receptor stereocilium organization (GO:0060122)2.58709544
73respiratory chain complex IV assembly (GO:0008535)2.57578390
74regulation of hexokinase activity (GO:1903299)2.57209924
75regulation of glucokinase activity (GO:0033131)2.57209924
76negative regulation of translation, ncRNA-mediated (GO:0040033)2.56724242
77regulation of translation, ncRNA-mediated (GO:0045974)2.56724242
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56724242
79startle response (GO:0001964)2.56720903
80reciprocal DNA recombination (GO:0035825)2.55753813
81reciprocal meiotic recombination (GO:0007131)2.55753813
82mitochondrial respiratory chain complex assembly (GO:0033108)2.54347950
83primary amino compound metabolic process (GO:1901160)2.52321380
84C4-dicarboxylate transport (GO:0015740)2.51849030
85limb bud formation (GO:0060174)2.50109496
86neuronal action potential propagation (GO:0019227)2.49446812
87ubiquinone biosynthetic process (GO:0006744)2.48817683
88retinal ganglion cell axon guidance (GO:0031290)2.48224901
89rRNA catabolic process (GO:0016075)2.47671232
90cell proliferation in forebrain (GO:0021846)2.47470695
91ubiquinone metabolic process (GO:0006743)2.47354092
92presynaptic membrane organization (GO:0097090)2.46268585
93serotonin metabolic process (GO:0042428)2.45480061
94cellular response to ATP (GO:0071318)2.45183115
95replication fork processing (GO:0031297)2.45071136
96cell differentiation in spinal cord (GO:0021515)2.43160168
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42266059
98negative regulation of mast cell activation (GO:0033004)2.41880438
99regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40850100
100regulation of microtubule-based movement (GO:0060632)2.38568013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.91096947
2EZH2_22144423_ChIP-Seq_EOC_Human3.76562894
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16336794
4VDR_22108803_ChIP-Seq_LS180_Human3.15213238
5GBX2_23144817_ChIP-Seq_PC3_Human3.10041641
6IGF1R_20145208_ChIP-Seq_DFB_Human2.64262771
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64162766
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36784181
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29628001
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27112753
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19749303
12TAF15_26573619_Chip-Seq_HEK293_Human2.13493728
13EWS_26573619_Chip-Seq_HEK293_Human2.12376450
14FUS_26573619_Chip-Seq_HEK293_Human2.08235432
15P300_19829295_ChIP-Seq_ESCs_Human2.02335408
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02239017
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94251541
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.93522095
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.89487065
20ER_23166858_ChIP-Seq_MCF-7_Human1.79866403
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.79179494
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73437894
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70394718
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64361574
25REST_21632747_ChIP-Seq_MESCs_Mouse1.62147001
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61800228
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61330707
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60285669
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59152180
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54893203
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54458350
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52967613
33STAT3_23295773_ChIP-Seq_U87_Human1.52468547
34IRF1_19129219_ChIP-ChIP_H3396_Human1.52052050
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51907676
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51721421
37TP53_22573176_ChIP-Seq_HFKS_Human1.50596649
38CBP_20019798_ChIP-Seq_JUKART_Human1.49929042
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49929042
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49665368
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49665368
42BCAT_22108803_ChIP-Seq_LS180_Human1.49472103
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.48313181
44RNF2_27304074_Chip-Seq_NSC_Mouse1.46112506
45AR_25329375_ChIP-Seq_VCAP_Human1.45436118
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45012868
47AR_21572438_ChIP-Seq_LNCaP_Human1.44776306
48SMAD4_21799915_ChIP-Seq_A2780_Human1.44132549
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41758906
50TCF4_23295773_ChIP-Seq_U87_Human1.39429507
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38560318
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36889722
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36681634
54MYC_18940864_ChIP-ChIP_HL60_Human1.36465617
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.36104060
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33366160
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.32391334
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31523334
59TCF4_22108803_ChIP-Seq_LS180_Human1.27183209
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24612605
61RUNX2_22187159_ChIP-Seq_PCA_Human1.22948774
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.21794987
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20491308
64SOX2_19829295_ChIP-Seq_ESCs_Human1.20277063
65NANOG_19829295_ChIP-Seq_ESCs_Human1.20277063
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18032993
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.18032993
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17181394
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17081200
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16355576
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15197926
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13579417
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13048698
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12995203
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12901541
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.12434617
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.12049505
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.11870770
79NCOR_22424771_ChIP-Seq_293T_Human1.11796645
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.11316698
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.07802563
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.07078288
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06698567
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.04926868
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04768079
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.04761542
87AR_20517297_ChIP-Seq_VCAP_Human1.03124940
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.03021992
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03007592
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02764821
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.02197729
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00271443
93EZH2_27294783_Chip-Seq_ESCs_Mouse0.99708654
94* HOXB7_26014856_ChIP-Seq_BT474_Human0.99236823
95EST1_17652178_ChIP-ChIP_JURKAT_Human0.97703576
96DROSHA_22980978_ChIP-Seq_HELA_Human0.97295712
97P53_22387025_ChIP-Seq_ESCs_Mouse0.97240161
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95669368
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93399886
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93208837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.77804050
2MP0002102_abnormal_ear_morphology2.68886300
3MP0003787_abnormal_imprinting2.58712211
4MP0001968_abnormal_touch/_nociception2.51871058
5MP0005551_abnormal_eye_electrophysiolog2.39302534
6MP0003136_yellow_coat_color2.23688890
7MP0000569_abnormal_digit_pigmentation2.18360349
8MP0003195_calcinosis2.08092789
9MP0009745_abnormal_behavioral_response2.04704511
10MP0006292_abnormal_olfactory_placode2.03737271
11MP0006072_abnormal_retinal_apoptosis2.03375563
12MP0002736_abnormal_nociception_after2.00247025
13MP0003880_abnormal_central_pattern1.99861293
14MP0009046_muscle_twitch1.98798396
15MP0006276_abnormal_autonomic_nervous1.97414859
16MP0001986_abnormal_taste_sensitivity1.95700228
17MP0005646_abnormal_pituitary_gland1.90437272
18MP0004885_abnormal_endolymph1.89889134
19MP0005253_abnormal_eye_physiology1.88614005
20MP0002638_abnormal_pupillary_reflex1.87058434
21MP0004133_heterotaxia1.86977023
22MP0004142_abnormal_muscle_tone1.86945574
23MP0003646_muscle_fatigue1.84843738
24MP0005645_abnormal_hypothalamus_physiol1.84468346
25MP0002653_abnormal_ependyma_morphology1.82572089
26MP0002837_dystrophic_cardiac_calcinosis1.71736088
27MP0008872_abnormal_physiological_respon1.71053628
28MP0001984_abnormal_olfaction1.70245503
29MP0002272_abnormal_nervous_system1.70178712
30MP0004043_abnormal_pH_regulation1.70102871
31MP0008875_abnormal_xenobiotic_pharmacok1.70061223
32MP0002735_abnormal_chemical_nociception1.69449564
33MP0003011_delayed_dark_adaptation1.67444157
34MP0000631_abnormal_neuroendocrine_gland1.63886020
35MP0000427_abnormal_hair_cycle1.63775995
36MP0002876_abnormal_thyroid_physiology1.60053415
37MP0001486_abnormal_startle_reflex1.58953647
38MP0000778_abnormal_nervous_system1.58741788
39MP0001501_abnormal_sleep_pattern1.58441554
40MP0002572_abnormal_emotion/affect_behav1.55796745
41MP0002064_seizures1.46727525
42MP0003122_maternal_imprinting1.44322015
43MP0001485_abnormal_pinna_reflex1.44161175
44MP0002557_abnormal_social/conspecific_i1.41319226
45MP0000372_irregular_coat_pigmentation1.40604755
46MP0004145_abnormal_muscle_electrophysio1.40147087
47MP0002938_white_spotting1.40051889
48MP0003635_abnormal_synaptic_transmissio1.39318507
49MP0003121_genomic_imprinting1.37611712
50MP0002063_abnormal_learning/memory/cond1.34957810
51MP0001529_abnormal_vocalization1.32157378
52MP0002733_abnormal_thermal_nociception1.29837296
53MP0001970_abnormal_pain_threshold1.29472885
54MP0004147_increased_porphyrin_level1.27486693
55MP0002928_abnormal_bile_duct1.23944069
56MP0004742_abnormal_vestibular_system1.23206393
57MP0002067_abnormal_sensory_capabilities1.21240826
58MP0002234_abnormal_pharynx_morphology1.20986591
59MP0005423_abnormal_somatic_nervous1.18507503
60MP0005084_abnormal_gallbladder_morpholo1.15966800
61MP0005195_abnormal_posterior_eye1.14728486
62MP0002734_abnormal_mechanical_nocicepti1.14575846
63MP0002751_abnormal_autonomic_nervous1.14076841
64MP0005386_behavior/neurological_phenoty1.13464958
65MP0004924_abnormal_behavior1.13464958
66MP0002184_abnormal_innervation1.13321272
67MP0002095_abnormal_skin_pigmentation1.11944160
68MP0005174_abnormal_tail_pigmentation1.10981742
69MP0002752_abnormal_somatic_nervous1.08283548
70MP0001905_abnormal_dopamine_level1.06832675
71MP0001502_abnormal_circadian_rhythm1.06616098
72MP0008789_abnormal_olfactory_epithelium1.06102311
73MP0000383_abnormal_hair_follicle1.04496260
74MP0002160_abnormal_reproductive_system1.04417670
75MP0005389_reproductive_system_phenotype0.99698196
76MP0000026_abnormal_inner_ear0.99599202
77MP0008995_early_reproductive_senescence0.99007945
78MP0000647_abnormal_sebaceous_gland0.97857268
79MP0003119_abnormal_digestive_system0.91697336
80MP0000049_abnormal_middle_ear0.91445050
81MP0000230_abnormal_systemic_arterial0.90237700
82MP0002882_abnormal_neuron_morphology0.89351893
83MP0000955_abnormal_spinal_cord0.89223665
84MP0008775_abnormal_heart_ventricle0.87942279
85MP0005167_abnormal_blood-brain_barrier0.87501248
86MP0010386_abnormal_urinary_bladder0.86943502
87MP0003698_abnormal_male_reproductive0.85536047
88MP0003137_abnormal_impulse_conducting0.85477873
89MP0001963_abnormal_hearing_physiology0.85380257
90MP0005187_abnormal_penis_morphology0.84552928
91MP0003718_maternal_effect0.83700974
92MP0002909_abnormal_adrenal_gland0.82934240
93MP0005391_vision/eye_phenotype0.82858777
94MP0001324_abnormal_eye_pigmentation0.82769273
95MP0002163_abnormal_gland_morphology0.82387311
96MP0005171_absent_coat_pigmentation0.82248174
97MP0001293_anophthalmia0.80572408
98MP0003937_abnormal_limbs/digits/tail_de0.80266949
99MP0005410_abnormal_fertilization0.78753293
100MP0001919_abnormal_reproductive_system0.77907473

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.59135279
2Pancreatic fibrosis (HP:0100732)4.26089352
3Molar tooth sign on MRI (HP:0002419)4.17554272
4Abnormality of midbrain morphology (HP:0002418)4.17554272
5True hermaphroditism (HP:0010459)4.15021992
6Type II lissencephaly (HP:0007260)3.88921853
7Congenital stationary night blindness (HP:0007642)3.81698112
8Nephronophthisis (HP:0000090)3.73019461
9Hyperventilation (HP:0002883)3.34773262
10Abnormality of the renal medulla (HP:0100957)3.26537556
11Medial flaring of the eyebrow (HP:0010747)3.14980132
12Abnormality of the renal cortex (HP:0011035)3.13788792
13Lissencephaly (HP:0001339)2.89978535
14Chronic hepatic failure (HP:0100626)2.89266986
15Cystic liver disease (HP:0006706)2.87812943
16Attenuation of retinal blood vessels (HP:0007843)2.81249076
17Gait imbalance (HP:0002141)2.67473258
18Abnormal drinking behavior (HP:0030082)2.64758421
19Polydipsia (HP:0001959)2.64758421
20Pendular nystagmus (HP:0012043)2.61897713
21Abolished electroretinogram (ERG) (HP:0000550)2.58737064
22Sclerocornea (HP:0000647)2.57282009
23Tubular atrophy (HP:0000092)2.56485282
24Inability to walk (HP:0002540)2.55054430
25Retinal dysplasia (HP:0007973)2.54073657
26Cerebellar dysplasia (HP:0007033)2.53017859
27Congenital primary aphakia (HP:0007707)2.51347101
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43393896
29Abnormality of alanine metabolism (HP:0010916)2.43393896
30Hyperalaninemia (HP:0003348)2.43393896
31Anencephaly (HP:0002323)2.39971398
32Nephrogenic diabetes insipidus (HP:0009806)2.34584828
33Pachygyria (HP:0001302)2.34162559
34Renal cortical cysts (HP:0000803)2.29875892
35Progressive inability to walk (HP:0002505)2.28740108
36Increased corneal curvature (HP:0100692)2.25514297
37Keratoconus (HP:0000563)2.25514297
38Progressive cerebellar ataxia (HP:0002073)2.24245587
39Decreased central vision (HP:0007663)2.23474406
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.21017453
41Bile duct proliferation (HP:0001408)2.20868958
42Abnormal biliary tract physiology (HP:0012439)2.20868958
43Absent/shortened dynein arms (HP:0200106)2.19000217
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.19000217
45Patellar aplasia (HP:0006443)2.18620070
46Genital tract atresia (HP:0001827)2.17821995
47Broad-based gait (HP:0002136)2.17383567
48Abnormal rod and cone electroretinograms (HP:0008323)2.15598837
49Congenital hepatic fibrosis (HP:0002612)2.15596146
50Vaginal atresia (HP:0000148)2.12946726
51Postaxial foot polydactyly (HP:0001830)2.12630624
52Gaze-evoked nystagmus (HP:0000640)2.11360656
53Concave nail (HP:0001598)2.10678056
54Abnormal respiratory motile cilium morphology (HP:0005938)2.09109143
55Abnormal respiratory epithelium morphology (HP:0012253)2.09109143
56Chorioretinal atrophy (HP:0000533)2.08799914
57Absent speech (HP:0001344)2.08158845
58Large for gestational age (HP:0001520)2.07588691
59Genetic anticipation (HP:0003743)2.07031649
60Optic nerve hypoplasia (HP:0000609)2.07012903
61Aplasia/Hypoplasia of the patella (HP:0006498)2.05862651
62Male pseudohermaphroditism (HP:0000037)2.04367893
63Polyuria (HP:0000103)2.03915826
64Abnormality of the labia minora (HP:0012880)2.03106362
65Protruding tongue (HP:0010808)2.02623504
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01420317
67Hemiparesis (HP:0001269)2.00847006
68Furrowed tongue (HP:0000221)1.99848935
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99663240
70Bony spicule pigmentary retinopathy (HP:0007737)1.98385979
71Febrile seizures (HP:0002373)1.97699561
72Severe muscular hypotonia (HP:0006829)1.96936282
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.96412826
74Focal motor seizures (HP:0011153)1.92801980
75Occipital encephalocele (HP:0002085)1.88892496
76Decreased circulating renin level (HP:0003351)1.88881359
77Stomach cancer (HP:0012126)1.88870705
78Agitation (HP:0000713)1.88468750
79Colon cancer (HP:0003003)1.88085891
80Poor coordination (HP:0002370)1.86950463
81Postaxial hand polydactyly (HP:0001162)1.86342187
82Oligodactyly (hands) (HP:0001180)1.84650085
83Abnormality of the pons (HP:0007361)1.84561925
84Acute necrotizing encephalopathy (HP:0006965)1.84525634
85Increased CSF lactate (HP:0002490)1.84336928
86Mitochondrial inheritance (HP:0001427)1.84111274
87Hypoplasia of the pons (HP:0012110)1.80803761
88Dandy-Walker malformation (HP:0001305)1.78860657
89Congenital, generalized hypertrichosis (HP:0004540)1.78711313
90Methylmalonic acidemia (HP:0002912)1.78616064
91Polyphagia (HP:0002591)1.77385919
92Tachypnea (HP:0002789)1.76374678
93Optic disc pallor (HP:0000543)1.75450248
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75370821
95Drooling (HP:0002307)1.74714213
96Rib fusion (HP:0000902)1.74540237
97Anophthalmia (HP:0000528)1.73403176
98Abnormal ciliary motility (HP:0012262)1.72879047
99Focal seizures (HP:0007359)1.72516111
100Intestinal atresia (HP:0011100)1.72328299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.05294035
2ADRBK23.01883824
3MAP4K23.01214821
4BMPR1B2.81981486
5TLK12.64409292
6CASK2.61363776
7WNK32.48837496
8MARK12.36336196
9PINK12.34864645
10ZAK2.33207855
11GRK12.31942675
12INSRR2.29683055
13WNK42.29190999
14MAP3K42.23604592
15NUAK12.17690090
16TAOK32.15892031
17MAPK132.15368127
18ACVR1B2.03933209
19MAPK151.57656077
20MAP2K71.54045249
21OXSR11.52341703
22PNCK1.46475568
23DYRK21.45963785
24DAPK21.34345831
25STK391.33948989
26MKNK21.27447249
27TRIM281.21283759
28TNIK1.20871871
29BCR1.15805343
30PAK31.13610673
31ADRBK11.13338023
32PRKCG1.08488101
33TXK1.08251349
34NTRK21.04470936
35VRK11.03952973
36CSNK1G20.95390474
37PRKCE0.95229008
38BCKDK0.94296783
39CAMKK20.92151471
40NTRK30.91602314
41TGFBR10.89836006
42PHKG20.82275982
43PHKG10.82275982
44CSNK1G10.81415484
45PLK20.80313860
46SIK20.78843559
47CSNK1G30.78504607
48TIE10.77255816
49BRSK20.74509705
50PKN10.73269764
51EPHA40.70694564
52CSNK1A1L0.69782505
53PIK3CA0.69541209
54STK38L0.64005341
55MAPKAPK30.62619860
56FGFR20.62016728
57ERBB30.61917674
58RPS6KA50.61868511
59MAP2K60.60884698
60MKNK10.59636371
61MUSK0.57711060
62EPHA30.57687370
63CAMK2A0.57527462
64WEE10.56939631
65MAPKAPK50.56127505
66PRKCI0.50884320
67PRKCQ0.49477281
68CSNK1A10.49088110
69PRKACA0.48278266
70STK110.47767811
71TEC0.47682077
72OBSCN0.46880651
73MAP2K40.46571105
74PTK2B0.46419758
75TAF10.45673978
76CAMK10.45514021
77PLK30.44391710
78DYRK1A0.42437081
79AKT30.40929696
80ATR0.40870293
81SGK20.40652973
82MINK10.39871634
83KIT0.39652202
84CDK30.38429284
85PRKCZ0.37855812
86PRKAA10.37605316
87CSNK1D0.37527265
88VRK20.37380713
89SGK2230.34649853
90SGK4940.34649853
91NME10.33658753
92PRKG10.33405630
93PLK40.33244980
94IRAK10.32094057
95CHUK0.31891841
96ERBB20.31814753
97NEK20.31569985
98CDK190.31485535
99DYRK30.31381580
100PRKCA0.30321507

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.95818755
2Nicotine addiction_Homo sapiens_hsa050332.74661187
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59009865
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.47343531
5Linoleic acid metabolism_Homo sapiens_hsa005912.43550566
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43136827
7Nitrogen metabolism_Homo sapiens_hsa009102.41249992
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36692110
9Butanoate metabolism_Homo sapiens_hsa006502.26527165
10Oxidative phosphorylation_Homo sapiens_hsa001902.16730708
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15493578
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11988590
13Selenocompound metabolism_Homo sapiens_hsa004502.03492664
14Caffeine metabolism_Homo sapiens_hsa002322.01159910
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.86125584
16Tryptophan metabolism_Homo sapiens_hsa003801.85727138
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84384259
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79474011
19Protein export_Homo sapiens_hsa030601.77397328
20Ether lipid metabolism_Homo sapiens_hsa005651.70765767
21Homologous recombination_Homo sapiens_hsa034401.67525550
22Parkinsons disease_Homo sapiens_hsa050121.66177412
23Fanconi anemia pathway_Homo sapiens_hsa034601.64929639
24Taste transduction_Homo sapiens_hsa047421.59576931
25Morphine addiction_Homo sapiens_hsa050321.59553237
26Basal transcription factors_Homo sapiens_hsa030221.56001344
27RNA polymerase_Homo sapiens_hsa030201.49201651
28Olfactory transduction_Homo sapiens_hsa047401.45744392
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33889747
30GABAergic synapse_Homo sapiens_hsa047271.28573037
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27942100
32Cardiac muscle contraction_Homo sapiens_hsa042601.26971618
33Circadian entrainment_Homo sapiens_hsa047131.24766468
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22683118
35Glutamatergic synapse_Homo sapiens_hsa047241.20107506
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18615026
37ABC transporters_Homo sapiens_hsa020101.15572063
38Propanoate metabolism_Homo sapiens_hsa006401.14307445
39RNA degradation_Homo sapiens_hsa030181.13221735
40Peroxisome_Homo sapiens_hsa041461.12787336
41Huntingtons disease_Homo sapiens_hsa050161.11648207
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.09695387
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09291012
44Insulin secretion_Homo sapiens_hsa049111.07898812
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.06173253
46Chemical carcinogenesis_Homo sapiens_hsa052041.03801008
47Serotonergic synapse_Homo sapiens_hsa047261.00861018
48Alzheimers disease_Homo sapiens_hsa050101.00611309
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.00297582
50One carbon pool by folate_Homo sapiens_hsa006700.97109987
51Regulation of autophagy_Homo sapiens_hsa041400.91930338
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91523686
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89604868
54Ovarian steroidogenesis_Homo sapiens_hsa049130.86622697
55Retinol metabolism_Homo sapiens_hsa008300.86076401
56Salivary secretion_Homo sapiens_hsa049700.85580547
57Arachidonic acid metabolism_Homo sapiens_hsa005900.85019054
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83771386
59Cocaine addiction_Homo sapiens_hsa050300.82014091
60Dopaminergic synapse_Homo sapiens_hsa047280.81268769
61Collecting duct acid secretion_Homo sapiens_hsa049660.75469069
62beta-Alanine metabolism_Homo sapiens_hsa004100.75237122
63Calcium signaling pathway_Homo sapiens_hsa040200.73581718
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68136748
65Asthma_Homo sapiens_hsa053100.65444157
66Hedgehog signaling pathway_Homo sapiens_hsa043400.64112919
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63781890
68Purine metabolism_Homo sapiens_hsa002300.61885684
69Glycerolipid metabolism_Homo sapiens_hsa005610.61072499
70Amphetamine addiction_Homo sapiens_hsa050310.60634547
71Circadian rhythm_Homo sapiens_hsa047100.60222889
72Long-term depression_Homo sapiens_hsa047300.59620664
73Steroid biosynthesis_Homo sapiens_hsa001000.58019809
74Non-homologous end-joining_Homo sapiens_hsa034500.53662117
75Metabolic pathways_Homo sapiens_hsa011000.52674698
76Histidine metabolism_Homo sapiens_hsa003400.51385749
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51161314
78Fat digestion and absorption_Homo sapiens_hsa049750.50957040
79Sulfur metabolism_Homo sapiens_hsa009200.50951752
80Sulfur relay system_Homo sapiens_hsa041220.49052050
81Basal cell carcinoma_Homo sapiens_hsa052170.44099896
82cAMP signaling pathway_Homo sapiens_hsa040240.42833407
83Axon guidance_Homo sapiens_hsa043600.42367404
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41709583
85Vitamin digestion and absorption_Homo sapiens_hsa049770.40244348
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39701533
87Cholinergic synapse_Homo sapiens_hsa047250.39399112
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38929112
89Dorso-ventral axis formation_Homo sapiens_hsa043200.38496802
90Primary immunodeficiency_Homo sapiens_hsa053400.37072910
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36914847
92Oxytocin signaling pathway_Homo sapiens_hsa049210.35308350
93Pyrimidine metabolism_Homo sapiens_hsa002400.34254477
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33930971
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.33798277
96Mineral absorption_Homo sapiens_hsa049780.33568843
97Type I diabetes mellitus_Homo sapiens_hsa049400.32474612
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32318777
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31892219
100Lysine degradation_Homo sapiens_hsa003100.29843424

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