ZNF711

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.17492785
2nuclear pore organization (GO:0006999)4.16028378
3nuclear pore complex assembly (GO:0051292)3.98118948
4regulation of DNA endoreduplication (GO:0032875)3.95969977
5sister chromatid segregation (GO:0000819)3.61849197
6DNA synthesis involved in DNA repair (GO:0000731)3.59763337
7histone H2A acetylation (GO:0043968)3.46575820
8mitotic sister chromatid segregation (GO:0000070)3.46085987
9presynaptic membrane assembly (GO:0097105)3.43447080
10sister chromatid cohesion (GO:0007062)3.35639152
11replication fork processing (GO:0031297)3.27956234
12non-recombinational repair (GO:0000726)3.27653747
13double-strand break repair via nonhomologous end joining (GO:0006303)3.27653747
14peripheral nervous system neuron development (GO:0048935)3.26328879
15meiotic chromosome segregation (GO:0045132)3.20836192
16DNA replication checkpoint (GO:0000076)3.18653321
17pyrimidine nucleobase catabolic process (GO:0006208)3.16600464
18proximal/distal pattern formation (GO:0009954)3.16298085
19presynaptic membrane organization (GO:0097090)3.14653895
20intraciliary transport (GO:0042073)3.02666096
21nucleotide-excision repair, DNA gap filling (GO:0006297)3.01087137
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.00350744
23negative regulation of DNA recombination (GO:0045910)2.98220997
24translesion synthesis (GO:0019985)2.97857246
25pore complex assembly (GO:0046931)2.97075785
26synapsis (GO:0007129)2.95379864
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93067259
28dosage compensation (GO:0007549)2.83713654
29DNA replication initiation (GO:0006270)2.82189436
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80956660
31somatic hypermutation of immunoglobulin genes (GO:0016446)2.80037534
32somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80037534
33negative regulation of mRNA processing (GO:0050686)2.79065201
34DNA unwinding involved in DNA replication (GO:0006268)2.78864935
35mRNA splice site selection (GO:0006376)2.74049235
36microtubule depolymerization (GO:0007019)2.72260919
37olfactory bulb development (GO:0021772)2.66536716
38postreplication repair (GO:0006301)2.65908291
39neural tube formation (GO:0001841)2.65890524
40negative regulation of chromosome segregation (GO:0051985)2.65338113
41DNA strand elongation involved in DNA replication (GO:0006271)2.63949289
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60875807
43regulation of mitotic spindle checkpoint (GO:1903504)2.60875807
44regulation of sister chromatid cohesion (GO:0007063)2.60337515
45negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.59639882
46negative regulation of cell cycle G2/M phase transition (GO:1902750)2.58428671
47DNA double-strand break processing (GO:0000729)2.57513386
48microtubule anchoring (GO:0034453)2.56606015
49attachment of spindle microtubules to kinetochore (GO:0008608)2.55829375
50regulation of mRNA splicing, via spliceosome (GO:0048024)2.55717753
51retinal ganglion cell axon guidance (GO:0031290)2.55034387
52resolution of meiotic recombination intermediates (GO:0000712)2.54522418
53postsynaptic membrane organization (GO:0001941)2.54115765
54chromatin remodeling at centromere (GO:0031055)2.53663546
55atrial cardiac muscle cell action potential (GO:0086014)2.52212659
56mitotic nuclear envelope disassembly (GO:0007077)2.50031440
57intra-S DNA damage checkpoint (GO:0031573)2.49476083
58regulation of sister chromatid segregation (GO:0033045)2.49220112
59regulation of mitotic sister chromatid separation (GO:0010965)2.49220112
60regulation of mitotic sister chromatid segregation (GO:0033047)2.49220112
61DNA strand elongation (GO:0022616)2.47927529
62negative regulation of mitotic sister chromatid separation (GO:2000816)2.47833548
63negative regulation of sister chromatid segregation (GO:0033046)2.47833548
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.47833548
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.47833548
66negative regulation of mitotic sister chromatid segregation (GO:0033048)2.47833548
67gastrulation with mouth forming second (GO:0001702)2.47710489
68centriole replication (GO:0007099)2.45687984
69regulation of centriole replication (GO:0046599)2.45644887
70telomere maintenance via semi-conservative replication (GO:0032201)2.45338083
71neuron cell-cell adhesion (GO:0007158)2.45132897
72establishment of mitochondrion localization (GO:0051654)2.45099766
73spindle checkpoint (GO:0031577)2.44774335
74pre-miRNA processing (GO:0031054)2.43270785
75limb bud formation (GO:0060174)2.42956618
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.42738933
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.42738933
78positive regulation of mitotic sister chromatid separation (GO:1901970)2.42738933
79mitotic spindle assembly checkpoint (GO:0007094)2.42613220
80negative regulation of neurotransmitter secretion (GO:0046929)2.41616838
81hindbrain development (GO:0030902)2.40774536
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.39071239
83negative regulation of RNA splicing (GO:0033119)2.39032868
84mitotic spindle checkpoint (GO:0071174)2.38848623
85regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.38661942
86regulation of mitotic metaphase/anaphase transition (GO:0030071)2.38661942
87spindle assembly checkpoint (GO:0071173)2.38072569
88kinetochore organization (GO:0051383)2.36165038
89nucleobase catabolic process (GO:0046113)2.36067614
90nonmotile primary cilium assembly (GO:0035058)2.35686592
91DNA ligation (GO:0006266)2.34677058
92membrane disassembly (GO:0030397)2.34420898
93nuclear envelope disassembly (GO:0051081)2.34420898
94DNA topological change (GO:0006265)2.34167073
95DNA replication-dependent nucleosome assembly (GO:0006335)2.33611891
96DNA replication-dependent nucleosome organization (GO:0034723)2.33611891
97positive regulation of cell cycle checkpoint (GO:1901978)2.33059994
98DNA geometric change (GO:0032392)2.32750042
99DNA duplex unwinding (GO:0032508)2.31253076
100DNA damage response, detection of DNA damage (GO:0042769)2.30119506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.63090778
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.45502016
3FUS_26573619_Chip-Seq_HEK293_Human3.01833506
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99470181
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91513217
6GBX2_23144817_ChIP-Seq_PC3_Human2.57752074
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.52191860
8IGF1R_20145208_ChIP-Seq_DFB_Human2.51485165
9EWS_26573619_Chip-Seq_HEK293_Human2.51391409
10EZH2_22144423_ChIP-Seq_EOC_Human2.39631088
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37691232
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34727019
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32542572
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32295722
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.29107731
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.27324115
17TAF15_26573619_Chip-Seq_HEK293_Human2.24184237
18RNF2_27304074_Chip-Seq_NSC_Mouse2.22540179
19ZNF274_21170338_ChIP-Seq_K562_Hela2.20913087
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09314222
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90851163
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89884678
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86771441
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.86703827
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85804535
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83014044
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78948741
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60899281
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.60130727
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56508098
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55813271
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54867433
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.54062253
34* P300_19829295_ChIP-Seq_ESCs_Human1.52564899
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50930260
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49561343
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48348289
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.46487452
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46440386
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44275297
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43026109
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43022083
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40483669
44MYC_18940864_ChIP-ChIP_HL60_Human1.40421269
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38804610
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36867847
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34626322
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27576163
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27576163
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27293834
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26074692
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25157838
53ELK1_19687146_ChIP-ChIP_HELA_Human1.25012555
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23050794
55SMAD4_21799915_ChIP-Seq_A2780_Human1.21998064
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.21895638
57CBP_20019798_ChIP-Seq_JUKART_Human1.21159985
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21159985
59TTF2_22483619_ChIP-Seq_HELA_Human1.19671586
60* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19442037
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17609542
62IRF1_19129219_ChIP-ChIP_H3396_Human1.17548187
63SOX9_26525672_Chip-Seq_HEART_Mouse1.17518007
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15614911
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12804858
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11351288
67VDR_22108803_ChIP-Seq_LS180_Human1.11329708
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08974833
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08974833
70* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08959588
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08547062
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08103030
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.07960463
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06466388
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.06296946
76STAT3_23295773_ChIP-Seq_U87_Human1.05824202
77* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05771114
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05652931
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04971536
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04657728
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03880530
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02695494
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00880004
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99683152
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99549611
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98523277
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98178074
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97507210
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97423347
90REST_21632747_ChIP-Seq_MESCs_Mouse0.96508987
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.96081968
92ETS1_20019798_ChIP-Seq_JURKAT_Human0.95569316
93RUNX2_22187159_ChIP-Seq_PCA_Human0.95063679
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93295878
95VDR_23849224_ChIP-Seq_CD4+_Human0.92111267
96* XRN2_22483619_ChIP-Seq_HELA_Human0.91659756
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.91565960
98AR_21572438_ChIP-Seq_LNCaP_Human0.91439279
99POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90933642
100JUN_21703547_ChIP-Seq_K562_Human0.90147104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability2.80015504
2MP0008057_abnormal_DNA_replication2.71776084
3MP0008058_abnormal_DNA_repair2.47324769
4MP0006292_abnormal_olfactory_placode2.32948993
5MP0005187_abnormal_penis_morphology2.21289296
6MP0003111_abnormal_nucleus_morphology2.08397168
7MP0000778_abnormal_nervous_system2.04989870
8MP0008877_abnormal_DNA_methylation2.04130593
9MP0000537_abnormal_urethra_morphology2.03523377
10MP0002009_preneoplasia2.02975587
11MP0003880_abnormal_central_pattern1.97761451
12MP0003121_genomic_imprinting1.93957807
13MP0008995_early_reproductive_senescence1.89448362
14MP0002234_abnormal_pharynx_morphology1.87100686
15MP0002102_abnormal_ear_morphology1.86117248
16MP0003937_abnormal_limbs/digits/tail_de1.84828357
17MP0003077_abnormal_cell_cycle1.68882127
18MP0002249_abnormal_larynx_morphology1.67224653
19MP0000566_synostosis1.64867910
20MP0001529_abnormal_vocalization1.64495038
21MP0003787_abnormal_imprinting1.64245177
22MP0005367_renal/urinary_system_phenotyp1.63575735
23MP0000516_abnormal_urinary_system1.63575735
24MP0001188_hyperpigmentation1.60384652
25MP0001293_anophthalmia1.55421759
26MP0008932_abnormal_embryonic_tissue1.53733734
27MP0000049_abnormal_middle_ear1.53380013
28MP0000631_abnormal_neuroendocrine_gland1.53288107
29MP0003890_abnormal_embryonic-extraembry1.51542467
30MP0002233_abnormal_nose_morphology1.50941811
31MP0003119_abnormal_digestive_system1.46964763
32MP0002938_white_spotting1.45802167
33MP0009697_abnormal_copulation1.43250524
34MP0003315_abnormal_perineum_morphology1.41486767
35MP0003122_maternal_imprinting1.39689695
36MP0003861_abnormal_nervous_system1.37572878
37MP0003693_abnormal_embryo_hatching1.35765780
38MP0001984_abnormal_olfaction1.34577055
39MP0000955_abnormal_spinal_cord1.33337770
40MP0002697_abnormal_eye_size1.32977947
41MP0003136_yellow_coat_color1.30251013
42MP0002160_abnormal_reproductive_system1.27839432
43MP0008789_abnormal_olfactory_epithelium1.27520493
44MP0003938_abnormal_ear_development1.27206318
45MP0005499_abnormal_olfactory_system1.26887745
46MP0005394_taste/olfaction_phenotype1.26887745
47MP0006276_abnormal_autonomic_nervous1.26304894
48MP0001346_abnormal_lacrimal_gland1.24659549
49MP0002084_abnormal_developmental_patter1.22896171
50MP0005645_abnormal_hypothalamus_physiol1.19971098
51MP0001286_abnormal_eye_development1.19414243
52MP0001486_abnormal_startle_reflex1.19031156
53MP0003786_premature_aging1.18347173
54MP0004859_abnormal_synaptic_plasticity1.13398548
55MP0002822_catalepsy1.11497752
56MP0004133_heterotaxia1.11300236
57MP0008007_abnormal_cellular_replicative1.10156356
58MP0003942_abnormal_urinary_system1.10151154
59MP0009046_muscle_twitch1.09833296
60MP0003935_abnormal_craniofacial_develop1.09245867
61MP0004957_abnormal_blastocyst_morpholog1.08829901
62MP0003755_abnormal_palate_morphology1.08651890
63MP0002210_abnormal_sex_determination1.08597252
64MP0003567_abnormal_fetal_cardiomyocyte1.07289469
65MP0003635_abnormal_synaptic_transmissio1.06493064
66MP0002557_abnormal_social/conspecific_i1.05936586
67MP0003385_abnormal_body_wall1.05034516
68MP0002063_abnormal_learning/memory/cond1.04652761
69MP0002184_abnormal_innervation1.04265748
70MP0003123_paternal_imprinting1.03518589
71MP0002152_abnormal_brain_morphology1.03120132
72MP0004811_abnormal_neuron_physiology1.01933990
73MP0002734_abnormal_mechanical_nocicepti1.01202373
74MP0003698_abnormal_male_reproductive1.00618004
75MP0002085_abnormal_embryonic_tissue1.00070109
76MP0001929_abnormal_gametogenesis0.99496036
77MP0001145_abnormal_male_reproductive0.98394699
78MP0005646_abnormal_pituitary_gland0.97841820
79MP0010307_abnormal_tumor_latency0.96728330
80MP0002282_abnormal_trachea_morphology0.96672651
81MP0004270_analgesia0.96311517
82MP0004742_abnormal_vestibular_system0.95870431
83MP0002736_abnormal_nociception_after0.94396641
84MP0000534_abnormal_ureter_morphology0.93625130
85MP0002081_perinatal_lethality0.93512929
86MP0003283_abnormal_digestive_organ0.93499230
87MP0002751_abnormal_autonomic_nervous0.92861847
88MP0002882_abnormal_neuron_morphology0.92439700
89MP0000653_abnormal_sex_gland0.91276375
90MP0005391_vision/eye_phenotype0.91000275
91MP0002092_abnormal_eye_morphology0.90615152
92MP0006072_abnormal_retinal_apoptosis0.90151746
93MP0002752_abnormal_somatic_nervous0.89961242
94MP0009745_abnormal_behavioral_response0.86634167
95MP0005623_abnormal_meninges_morphology0.86343618
96MP0009703_decreased_birth_body0.84816571
97MP0002114_abnormal_axial_skeleton0.83826762
98MP0005253_abnormal_eye_physiology0.82535417
99MP0001299_abnormal_eye_distance/0.82314184
100MP0003943_abnormal_hepatobiliary_system0.81667279

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.94439737
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78173587
3Chromsome breakage (HP:0040012)3.71059532
4Abnormality of chromosome stability (HP:0003220)2.86053424
5Abnormality of cochlea (HP:0000375)2.85990774
6Colon cancer (HP:0003003)2.74957856
7Hyperventilation (HP:0002883)2.73588543
8Abnormality of the labia minora (HP:0012880)2.70806143
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.70121393
10Morphological abnormality of the inner ear (HP:0011390)2.65566390
11Hepatoblastoma (HP:0002884)2.60867405
12Cortical dysplasia (HP:0002539)2.59078747
13Bifid tongue (HP:0010297)2.53384336
14Abnormality of the astrocytes (HP:0100707)2.53015890
15Astrocytoma (HP:0009592)2.53015890
16Meckel diverticulum (HP:0002245)2.52294623
17Abnormality of the ileum (HP:0001549)2.46817723
18Long clavicles (HP:0000890)2.43475083
19Drooling (HP:0002307)2.37573180
20Aplasia/Hypoplasia of the sternum (HP:0006714)2.31961296
21Abnormal lung lobation (HP:0002101)2.31291422
22High anterior hairline (HP:0009890)2.27484545
23Midline defect of the nose (HP:0004122)2.25616317
24Optic nerve coloboma (HP:0000588)2.22638719
25Sloping forehead (HP:0000340)2.21963424
26Gait imbalance (HP:0002141)2.21689523
27Cutaneous finger syndactyly (HP:0010554)2.20083690
28Oligodactyly (hands) (HP:0001180)2.19726979
29Glioma (HP:0009733)2.18795534
30Genital tract atresia (HP:0001827)2.18209498
31Vaginal atresia (HP:0000148)2.17233234
32Tubulointerstitial nephritis (HP:0001970)2.16804400
33Excessive salivation (HP:0003781)2.09693555
34Congenital primary aphakia (HP:0007707)2.07184182
35True hermaphroditism (HP:0010459)2.06923542
36Medulloblastoma (HP:0002885)2.05705025
37Lissencephaly (HP:0001339)2.04964805
38Poor coordination (HP:0002370)2.04388279
39Ectopic kidney (HP:0000086)2.04334009
40Preaxial hand polydactyly (HP:0001177)2.04280758
41Medial flaring of the eyebrow (HP:0010747)2.03734892
42Nephronophthisis (HP:0000090)2.03638433
43Triphalangeal thumb (HP:0001199)2.02230756
44Nephrogenic diabetes insipidus (HP:0009806)2.02116991
45Calcaneovalgus deformity (HP:0001848)1.98528751
46Birth length less than 3rd percentile (HP:0003561)1.98428487
47Limb hypertonia (HP:0002509)1.98290695
48Postaxial foot polydactyly (HP:0001830)1.98255788
49Pancreatic fibrosis (HP:0100732)1.96710800
50Patellar aplasia (HP:0006443)1.95629313
51Abnormality of the preputium (HP:0100587)1.94608544
52Cutaneous syndactyly (HP:0012725)1.92311765
53Abnormality of midbrain morphology (HP:0002418)1.91932830
54Molar tooth sign on MRI (HP:0002419)1.91932830
55Absent radius (HP:0003974)1.91418816
56Septate vagina (HP:0001153)1.89946956
57Aplasia involving forearm bones (HP:0009822)1.88077444
58Absent forearm bone (HP:0003953)1.88077444
59Truncal obesity (HP:0001956)1.87472263
60Pancreatic cysts (HP:0001737)1.87078860
61Abnormality of chromosome segregation (HP:0002916)1.85788413
62Duodenal stenosis (HP:0100867)1.85701260
63Small intestinal stenosis (HP:0012848)1.85701260
64Micropenis (HP:0000054)1.79842645
65Clubbing of toes (HP:0100760)1.76655413
66Aplasia/Hypoplasia of the patella (HP:0006498)1.74870328
67Deformed tarsal bones (HP:0008119)1.74644187
68Intestinal atresia (HP:0011100)1.74623105
69Renal dysplasia (HP:0000110)1.74384021
70Renal cortical cysts (HP:0000803)1.73428910
71Neoplasm of the adrenal cortex (HP:0100641)1.73166022
72Neoplasm of the oral cavity (HP:0100649)1.72534411
73Abnormality of the duodenum (HP:0002246)1.71703335
74Abnormal number of incisors (HP:0011064)1.70952017
75Absent eyebrow (HP:0002223)1.70292659
76Increased nuchal translucency (HP:0010880)1.69965711
77Rhabdomyosarcoma (HP:0002859)1.69578843
78Cupped ear (HP:0000378)1.69255386
79Abnormality of the 4th metacarpal (HP:0010012)1.68404578
80Bilateral microphthalmos (HP:0007633)1.68365234
81Chronic hepatic failure (HP:0100626)1.68142176
82Broad foot (HP:0001769)1.67968820
83Renal hypoplasia (HP:0000089)1.66916695
84Anencephaly (HP:0002323)1.65234769
85Oligodactyly (HP:0012165)1.64274717
86Nephroblastoma (Wilms tumor) (HP:0002667)1.64031650
87Abnormality of the carotid arteries (HP:0005344)1.63902304
88Postaxial hand polydactyly (HP:0001162)1.63674804
89Papillary thyroid carcinoma (HP:0002895)1.62467961
90Decreased lacrimation (HP:0000633)1.62246554
91Ependymoma (HP:0002888)1.62120424
92Abnormality of the renal medulla (HP:0100957)1.59686499
93Aqueductal stenosis (HP:0002410)1.59577487
94Optic nerve hypoplasia (HP:0000609)1.59185982
95Decreased testicular size (HP:0008734)1.58845671
96Broad distal phalanx of finger (HP:0009836)1.58063363
97Embryonal renal neoplasm (HP:0011794)1.57560681
98Retinal dysplasia (HP:0007973)1.56587011
99Alacrima (HP:0000522)1.55173008
100Anophthalmia (HP:0000528)1.54357015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.83067104
2CASK3.38727728
3MARK13.00236111
4SRPK12.84125741
5CDC72.47802261
6BRD42.32995767
7MKNK22.32162933
8TNIK2.31865128
9MAP3K42.19580556
10WNK32.19199495
11WEE12.09452018
12MKNK12.07907138
13BCR1.96275537
14CAMK1G1.94359807
15MAP4K21.84074593
16BUB11.78612499
17EPHA41.74500958
18MAPK131.74341752
19PLK41.70862484
20BRSK21.68174136
21FRK1.60652981
22ATR1.59804102
23CSNK1G11.59692321
24CSNK1G21.54462131
25CSNK1G31.50864310
26TRIM281.47272409
27BMPR1B1.47154414
28CSNK1A1L1.45817364
29CHEK21.43132944
30TTK1.41312228
31NUAK11.35404823
32ERBB31.30646076
33MAP2K71.29748494
34NTRK21.26121144
35PLK11.23896559
36ATM1.22156714
37CDK31.19638977
38DYRK21.13894535
39PLK31.12843257
40CHEK11.00427840
41ZAK0.99292117
42FGFR20.94605075
43CDK120.94343879
44INSRR0.93917988
45CAMK1D0.91789274
46MAP2K40.90825652
47UHMK10.87636919
48MINK10.86991179
49NEK10.85209690
50CCNB10.83413538
51STK38L0.80035696
52STK390.77070450
53VRK10.77012505
54BRSK10.75813614
55PLK20.75539300
56DYRK30.74522023
57DYRK1A0.73614732
58PHKG10.72616096
59PHKG20.72616096
60PRKDC0.72368670
61LATS10.70607443
62CDK20.69920863
63CAMKK20.66612513
64CSNK1D0.66327171
65CDK10.66249959
66AURKB0.64562094
67PRKCG0.63851796
68MAP3K100.62501327
69TAF10.61644722
70PAK30.60077071
71BCKDK0.59898253
72CSNK1E0.57269318
73ACVR1B0.57039788
74PINK10.56444841
75NEK20.54000664
76NLK0.53523554
77NTRK30.52937029
78TRIB30.52766695
79PASK0.51477707
80CDK180.51305748
81CDK70.50392030
82OXSR10.50240503
83CAMK40.50195282
84CDK150.49551515
85SGK20.48780055
86EPHB20.47530664
87PRKD30.47325310
88CDK11A0.46119900
89GSK3B0.44772128
90AKT30.44187103
91CDK190.44008204
92EEF2K0.43888085
93CDK140.42298796
94MAPK150.42006018
95PRKACB0.41783292
96CSNK1A10.41480468
97PRKAA10.41077437
98CDK50.40752978
99EIF2AK20.40090013
100STK160.38792692

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.01055071
2Fanconi anemia pathway_Homo sapiens_hsa034603.30419075
3DNA replication_Homo sapiens_hsa030303.15830849
4Mismatch repair_Homo sapiens_hsa034303.08605007
5Homologous recombination_Homo sapiens_hsa034402.66482381
6Cell cycle_Homo sapiens_hsa041102.47571836
7Base excision repair_Homo sapiens_hsa034102.29410026
8Nicotine addiction_Homo sapiens_hsa050332.26222299
9RNA transport_Homo sapiens_hsa030132.23363479
10Spliceosome_Homo sapiens_hsa030402.21459212
11Nucleotide excision repair_Homo sapiens_hsa034202.02469234
12Basal transcription factors_Homo sapiens_hsa030221.94209889
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93737592
14mRNA surveillance pathway_Homo sapiens_hsa030151.91672920
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74162265
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73345734
17Oocyte meiosis_Homo sapiens_hsa041141.62428163
18RNA degradation_Homo sapiens_hsa030181.59696140
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57794333
20Selenocompound metabolism_Homo sapiens_hsa004501.54095928
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.52614171
22Hedgehog signaling pathway_Homo sapiens_hsa043401.49295637
23Lysine degradation_Homo sapiens_hsa003101.48339915
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42833662
25Basal cell carcinoma_Homo sapiens_hsa052171.39656853
26One carbon pool by folate_Homo sapiens_hsa006701.33071033
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32351585
28Taste transduction_Homo sapiens_hsa047421.25094296
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18435257
30Propanoate metabolism_Homo sapiens_hsa006401.14293846
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09905308
32Protein export_Homo sapiens_hsa030601.09467811
33RNA polymerase_Homo sapiens_hsa030201.08241707
34Dopaminergic synapse_Homo sapiens_hsa047281.04311763
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04221889
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03774961
37Butanoate metabolism_Homo sapiens_hsa006501.02396909
38Steroid biosynthesis_Homo sapiens_hsa001000.99721642
39Hippo signaling pathway_Homo sapiens_hsa043900.99470212
40Phototransduction_Homo sapiens_hsa047440.97646621
41GABAergic synapse_Homo sapiens_hsa047270.97378541
42Axon guidance_Homo sapiens_hsa043600.97167467
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95526443
44Wnt signaling pathway_Homo sapiens_hsa043100.94918032
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94823929
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92870059
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91948908
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91750595
49Circadian entrainment_Homo sapiens_hsa047130.91625182
50Glutamatergic synapse_Homo sapiens_hsa047240.91067885
51TGF-beta signaling pathway_Homo sapiens_hsa043500.84500275
52Pyrimidine metabolism_Homo sapiens_hsa002400.81964273
53Purine metabolism_Homo sapiens_hsa002300.80413863
54Sulfur relay system_Homo sapiens_hsa041220.78798070
55Amphetamine addiction_Homo sapiens_hsa050310.77472374
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77050876
57Regulation of autophagy_Homo sapiens_hsa041400.75533458
58Morphine addiction_Homo sapiens_hsa050320.75245699
59p53 signaling pathway_Homo sapiens_hsa041150.74295418
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74055633
61Colorectal cancer_Homo sapiens_hsa052100.73937959
62Cocaine addiction_Homo sapiens_hsa050300.70910330
63Circadian rhythm_Homo sapiens_hsa047100.66833213
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.64546681
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64467572
66MicroRNAs in cancer_Homo sapiens_hsa052060.61122758
67Alcoholism_Homo sapiens_hsa050340.58337724
68Long-term depression_Homo sapiens_hsa047300.57681590
69AMPK signaling pathway_Homo sapiens_hsa041520.56273695
70Olfactory transduction_Homo sapiens_hsa047400.55365863
71Gap junction_Homo sapiens_hsa045400.53878637
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49982303
73Huntingtons disease_Homo sapiens_hsa050160.49861562
74Cholinergic synapse_Homo sapiens_hsa047250.48940954
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48557136
76Type II diabetes mellitus_Homo sapiens_hsa049300.47077202
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45133696
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.42905719
79Insulin secretion_Homo sapiens_hsa049110.41256276
80Melanogenesis_Homo sapiens_hsa049160.40733430
81Tight junction_Homo sapiens_hsa045300.39249353
82Serotonergic synapse_Homo sapiens_hsa047260.38706468
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38361244
84FoxO signaling pathway_Homo sapiens_hsa040680.37566732
85Parkinsons disease_Homo sapiens_hsa050120.37355886
86Vitamin B6 metabolism_Homo sapiens_hsa007500.37117026
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35469350
88Biosynthesis of amino acids_Homo sapiens_hsa012300.33835717
89Glycerolipid metabolism_Homo sapiens_hsa005610.33218135
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32646012
91cAMP signaling pathway_Homo sapiens_hsa040240.31490245
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31066735
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30733555
94Folate biosynthesis_Homo sapiens_hsa007900.29315055
95Calcium signaling pathway_Homo sapiens_hsa040200.28999108
96mTOR signaling pathway_Homo sapiens_hsa041500.28891481
97Salivary secretion_Homo sapiens_hsa049700.28739977
98Ether lipid metabolism_Homo sapiens_hsa005650.27668003
99Choline metabolism in cancer_Homo sapiens_hsa052310.26219972
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25538953

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