ZNF705G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K9 demethylation (GO:0033169)8.92027608
2acrosome reaction (GO:0007340)7.63962831
3plasma membrane fusion (GO:0045026)7.23281471
4multicellular organism reproduction (GO:0032504)7.15449013
5regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)6.62422036
6sperm motility (GO:0030317)5.78158260
7indole-containing compound catabolic process (GO:0042436)5.40707765
8indolalkylamine catabolic process (GO:0046218)5.40707765
9tryptophan catabolic process (GO:0006569)5.40707765
10spermatid development (GO:0007286)5.23397157
11reproduction (GO:0000003)5.19285585
12sperm-egg recognition (GO:0035036)5.18192137
13binding of sperm to zona pellucida (GO:0007339)5.17407765
14male meiosis (GO:0007140)5.01942044
15cilium or flagellum-dependent cell motility (GO:0001539)5.00998172
16calcium ion-dependent exocytosis (GO:0017156)4.90987282
17regulation of skeletal muscle contraction (GO:0014819)4.77416008
18fusion of sperm to egg plasma membrane (GO:0007342)4.77343535
19regulation of establishment of cell polarity (GO:2000114)4.70060982
20regulation of sarcomere organization (GO:0060297)4.69694557
21single fertilization (GO:0007338)4.68376286
22positive regulation of catecholamine secretion (GO:0033605)4.66797430
23indolalkylamine metabolic process (GO:0006586)4.66240003
24bundle of His cell to Purkinje myocyte communication (GO:0086069)4.60374426
25negative regulation of protein localization to cell surface (GO:2000009)4.50816643
26behavioral response to nicotine (GO:0035095)4.49547083
27NAD biosynthetic process (GO:0009435)4.36218522
28male meiosis I (GO:0007141)4.35481640
29kynurenine metabolic process (GO:0070189)4.35023212
30tryptophan metabolic process (GO:0006568)4.34815352
31neuronal action potential (GO:0019228)4.27992523
32cell-cell recognition (GO:0009988)4.25770252
33synaptonemal complex assembly (GO:0007130)4.20652676
34multicellular organismal movement (GO:0050879)4.19720368
35musculoskeletal movement (GO:0050881)4.19720368
36synaptonemal complex organization (GO:0070193)4.17732441
37myoblast fusion (GO:0007520)4.13198645
38motile cilium assembly (GO:0044458)4.06033371
39positive regulation of meiosis (GO:0045836)4.00239271
40cilium movement (GO:0003341)3.97345814
41positive regulation of meiotic cell cycle (GO:0051446)3.94162341
42oocyte development (GO:0048599)3.94039384
43gonadal mesoderm development (GO:0007506)3.90850543
44epithelial cilium movement (GO:0003351)3.78160261
45sex differentiation (GO:0007548)3.78032728
46striated muscle atrophy (GO:0014891)3.73793209
47syncytium formation (GO:0006949)3.73290223
48regulation of establishment or maintenance of cell polarity (GO:0032878)3.71213221
49negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.69091078
50protein K48-linked deubiquitination (GO:0071108)3.64552877
51axonemal dynein complex assembly (GO:0070286)3.64236355
52centrosome duplication (GO:0051298)3.60696620
53regulation of acrosome reaction (GO:0060046)3.60223125
54fertilization (GO:0009566)3.59877963
55protein K63-linked deubiquitination (GO:0070536)3.56325829
56regulation of phosphoprotein phosphatase activity (GO:0043666)3.56237627
57piRNA metabolic process (GO:0034587)3.54897879
58syncytium formation by plasma membrane fusion (GO:0000768)3.54873144
59single strand break repair (GO:0000012)3.49301569
60amine catabolic process (GO:0009310)3.47197808
61cellular biogenic amine catabolic process (GO:0042402)3.47197808
62nicotinamide nucleotide biosynthetic process (GO:0019359)3.45146556
63pyridine nucleotide biosynthetic process (GO:0019363)3.45146556
64histone lysine demethylation (GO:0070076)3.43770071
65meiosis I (GO:0007127)3.42067053
66microtubule polymerization or depolymerization (GO:0031109)3.36380800
67regulation of memory T cell differentiation (GO:0043380)3.35892966
68spermatogenesis (GO:0007283)3.33036471
69membrane depolarization during action potential (GO:0086010)3.33026776
70muscle cell cellular homeostasis (GO:0046716)3.32865257
71male gamete generation (GO:0048232)3.32325358
72negative regulation of Ras GTPase activity (GO:0034261)3.32129849
73ADP metabolic process (GO:0046031)3.31020366
74actin-myosin filament sliding (GO:0033275)3.29197785
75muscle filament sliding (GO:0030049)3.29197785
76indole-containing compound metabolic process (GO:0042430)3.29129602
77chromosome organization involved in meiosis (GO:0070192)3.28924141
78histone demethylation (GO:0016577)3.22416444
79regulation of action potential (GO:0098900)3.20607907
80muscle atrophy (GO:0014889)3.19946024
81germ cell development (GO:0007281)3.17404344
82postsynaptic membrane organization (GO:0001941)3.15106965
83ventricular system development (GO:0021591)3.14866668
84DNA methylation involved in gamete generation (GO:0043046)3.14006458
85cardiac myofibril assembly (GO:0055003)3.10737869
86regulation of posttranscriptional gene silencing (GO:0060147)3.08396620
87regulation of gene silencing by miRNA (GO:0060964)3.08396620
88regulation of gene silencing by RNA (GO:0060966)3.08396620
89aromatic amino acid family catabolic process (GO:0009074)3.07949494
90regulation of retinoic acid receptor signaling pathway (GO:0048385)3.06756374
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05600864
92meiotic nuclear division (GO:0007126)3.04610525
93gamete generation (GO:0007276)3.03831659
94actin-mediated cell contraction (GO:0070252)3.02334946
95centriole replication (GO:0007099)3.01833519
96regulation of female gonad development (GO:2000194)3.00746195
97regulation of interleukin-13 production (GO:0032656)2.99408302
98synaptic transmission, cholinergic (GO:0007271)2.98353713
99regulation of striated muscle contraction (GO:0006942)2.96105527
100sperm capacitation (GO:0048240)2.95965899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.45629544
2EZH2_22144423_ChIP-Seq_EOC_Human4.12499945
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.02958772
4IGF1R_20145208_ChIP-Seq_DFB_Human3.59394569
5GBX2_23144817_ChIP-Seq_PC3_Human2.92590636
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82076045
7* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.54904303
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54304418
9ZNF274_21170338_ChIP-Seq_K562_Hela2.15759159
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03957947
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02253119
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98373322
13CBP_20019798_ChIP-Seq_JUKART_Human1.92516024
14IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.92516024
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.87911669
16TAF15_26573619_Chip-Seq_HEK293_Human1.82092576
17STAT3_23295773_ChIP-Seq_U87_Human1.78471231
18SMAD4_21799915_ChIP-Seq_A2780_Human1.74930692
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74153628
20TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74153628
21P300_19829295_ChIP-Seq_ESCs_Human1.70325277
22ER_23166858_ChIP-Seq_MCF-7_Human1.67259381
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66117300
24BCAT_22108803_ChIP-Seq_LS180_Human1.65922158
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64872392
26SMAD4_21741376_ChIP-Seq_EPCs_Human1.62850097
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.57531989
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56944869
29AR_25329375_ChIP-Seq_VCAP_Human1.55761978
30TCF4_23295773_ChIP-Seq_U87_Human1.55384045
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54954689
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54951858
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54786174
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54011301
35PRDM14_20953172_ChIP-Seq_ESCs_Human1.53355568
36KLF5_20875108_ChIP-Seq_MESCs_Mouse1.50939136
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.50845472
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46791364
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43908674
40FUS_26573619_Chip-Seq_HEK293_Human1.40408716
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39477070
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38096043
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.36729072
44RUNX2_22187159_ChIP-Seq_PCA_Human1.36240627
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32071871
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31944009
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.30259507
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30252581
49NCOR_22424771_ChIP-Seq_293T_Human1.29636316
50CJUN_26792858_Chip-Seq_BT549_Human1.28972326
51OCT1_27270436_Chip-Seq_PROSTATE_Human1.28874368
52RXR_22108803_ChIP-Seq_LS180_Human1.28606151
53OCT4_20526341_ChIP-Seq_ESCs_Human1.28331147
54NANOG_20526341_ChIP-Seq_ESCs_Human1.28027593
55DROSHA_22980978_ChIP-Seq_HELA_Human1.28024292
56TCF4_22108803_ChIP-Seq_LS180_Human1.27093781
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27040216
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26183892
59AR_21572438_ChIP-Seq_LNCaP_Human1.23069541
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.21272232
61MYC_19829295_ChIP-Seq_ESCs_Human1.20846221
62RAC3_21632823_ChIP-Seq_H3396_Human1.19186343
63TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.19184983
64SOX2_19829295_ChIP-Seq_ESCs_Human1.18837829
65NANOG_19829295_ChIP-Seq_ESCs_Human1.18837829
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18418245
67SMAD4_21741376_ChIP-Seq_HESCs_Human1.17811461
68REST_21632747_ChIP-Seq_MESCs_Mouse1.17150419
69GF1_26923725_Chip-Seq_HPCs_Mouse1.16839544
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16713419
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15267435
72KDM2B_26808549_Chip-Seq_REH_Human1.15221125
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14296007
74CDX2_22108803_ChIP-Seq_LS180_Human1.13634207
75CBP_21632823_ChIP-Seq_H3396_Human1.13578753
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12926743
77* ERA_21632823_ChIP-Seq_H3396_Human1.11630710
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11155895
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09944151
80TP63_23658742_ChIP-Seq_EP156T_Human1.09881331
81TBL1_22424771_ChIP-Seq_293T_Human1.07740843
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.06157330
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04941495
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.04406234
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03282075
86FOXH1_21741376_ChIP-Seq_EPCs_Human1.02386710
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.01096902
88TAF2_19829295_ChIP-Seq_ESCs_Human0.99378777
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98776901
90AHR_22903824_ChIP-Seq_MCF-7_Human0.98457341
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97837253
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97538704
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97383288
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97131168
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.96918823
96JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94466627
97EED_16625203_ChIP-ChIP_MESCs_Mouse0.94387944
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93854146
99ERG_20517297_ChIP-Seq_VCAP_Human0.93616269
100TP53_18474530_ChIP-ChIP_U2OS_Human0.93318419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.79288822
2MP0003950_abnormal_plasma_membrane5.74104420
3MP0002736_abnormal_nociception_after4.67253850
4MP0000749_muscle_degeneration3.82537243
5MP0001968_abnormal_touch/_nociception3.82442743
6MP0001929_abnormal_gametogenesis2.40298290
7MP0003283_abnormal_digestive_organ2.39803920
8MP0003698_abnormal_male_reproductive2.34831152
9MP0000678_abnormal_parathyroid_gland2.33870667
10MP0003011_delayed_dark_adaptation2.25724173
11MP0003136_yellow_coat_color2.24248153
12MP0001501_abnormal_sleep_pattern2.12974602
13MP0005670_abnormal_white_adipose2.05298545
14MP0002160_abnormal_reproductive_system1.98458924
15MP0003718_maternal_effect1.89350972
16MP0006292_abnormal_olfactory_placode1.88940593
17MP0001485_abnormal_pinna_reflex1.85169420
18MP0006276_abnormal_autonomic_nervous1.80970568
19MP0001664_abnormal_digestion1.80710902
20MP0004084_abnormal_cardiac_muscle1.80480898
21MP0004233_abnormal_muscle_weight1.80076418
22MP0004510_myositis1.77378790
23MP0003646_muscle_fatigue1.66349226
24MP0002138_abnormal_hepatobiliary_system1.62197747
25MP0000427_abnormal_hair_cycle1.61612096
26MP0005647_abnormal_sex_gland1.58711474
27MP0003878_abnormal_ear_physiology1.56419743
28MP0005377_hearing/vestibular/ear_phenot1.56419743
29MP0001986_abnormal_taste_sensitivity1.55960262
30MP0003879_abnormal_hair_cell1.50023580
31MP0003252_abnormal_bile_duct1.46140968
32MP0002210_abnormal_sex_determination1.45429229
33MP0005253_abnormal_eye_physiology1.44060645
34MP0000569_abnormal_digit_pigmentation1.43618759
35MP0009745_abnormal_behavioral_response1.43467588
36MP0004036_abnormal_muscle_relaxation1.42873507
37MP0000230_abnormal_systemic_arterial1.42769737
38MP0002161_abnormal_fertility/fecundity1.40582766
39MP0010386_abnormal_urinary_bladder1.34732338
40MP0009046_muscle_twitch1.32029721
41MP0005360_urolithiasis1.31693111
42MP0004043_abnormal_pH_regulation1.29277523
43MP0004215_abnormal_myocardial_fiber1.25350567
44MP0005551_abnormal_eye_electrophysiolog1.24867810
45MP0002127_abnormal_cardiovascular_syste1.24440802
46MP0003119_abnormal_digestive_system1.22363300
47MP0002733_abnormal_thermal_nociception1.18893998
48MP0000653_abnormal_sex_gland1.16874485
49MP0002272_abnormal_nervous_system1.15996880
50MP0005646_abnormal_pituitary_gland1.12421835
51MP0002249_abnormal_larynx_morphology1.07931537
52MP0002108_abnormal_muscle_morphology1.04465324
53MP0002067_abnormal_sensory_capabilities1.04338756
54MP0005620_abnormal_muscle_contractility1.03274362
55MP0002269_muscular_atrophy1.00255020
56MP0001145_abnormal_male_reproductive0.99733148
57MP0003045_fibrosis0.97984333
58MP0008004_abnormal_stomach_pH0.97540012
59MP0003195_calcinosis0.95513124
60MP0001905_abnormal_dopamine_level0.94769322
61MP0009697_abnormal_copulation0.93868764
62MP0001666_abnormal_nutrient_absorption0.92470742
63MP0004085_abnormal_heartbeat0.90972536
64MP0001963_abnormal_hearing_physiology0.89403734
65MP0002837_dystrophic_cardiac_calcinosis0.89008537
66MP0000049_abnormal_middle_ear0.87792854
67MP0005174_abnormal_tail_pigmentation0.87189164
68MP0006072_abnormal_retinal_apoptosis0.87106694
69MP0001486_abnormal_startle_reflex0.86163179
70MP0000470_abnormal_stomach_morphology0.86115741
71MP0003699_abnormal_female_reproductive0.83684379
72MP0001970_abnormal_pain_threshold0.83478500
73MP0002132_abnormal_respiratory_system0.79951744
74MP0008058_abnormal_DNA_repair0.79886438
75MP0003137_abnormal_impulse_conducting0.79368426
76MP0005389_reproductive_system_phenotype0.79044660
77MP0008872_abnormal_physiological_respon0.78528057
78MP0000733_abnormal_muscle_development0.78282343
79MP0002229_neurodegeneration0.78049300
80MP0001765_abnormal_ion_homeostasis0.77814551
81MP0005395_other_phenotype0.77325808
82MP0000751_myopathy0.77175607
83MP0002102_abnormal_ear_morphology0.76379278
84MP0002282_abnormal_trachea_morphology0.76310284
85MP0008775_abnormal_heart_ventricle0.76279549
86MP0005423_abnormal_somatic_nervous0.75936609
87MP0000015_abnormal_ear_pigmentation0.74818677
88MP0003868_abnormal_feces_composition0.73453603
89MP0009384_cardiac_valve_regurgitation0.72910555
90MP0000631_abnormal_neuroendocrine_gland0.72733253
91MP0004145_abnormal_muscle_electrophysio0.71867441
92MP0000759_abnormal_skeletal_muscle0.69224854
93MP0002184_abnormal_innervation0.68882081
94MP0000026_abnormal_inner_ear0.68362240
95MP0001348_abnormal_lacrimal_gland0.66646770
96MP0005171_absent_coat_pigmentation0.65790708
97MP0004381_abnormal_hair_follicle0.65633901
98MP0002735_abnormal_chemical_nociception0.65309563
99MP0005379_endocrine/exocrine_gland_phen0.64777811
100MP0002734_abnormal_mechanical_nocicepti0.63682155

Predicted human phenotypes

RankGene SetZ-score
1Type 2 muscle fiber atrophy (HP:0003554)5.76945896
2Popliteal pterygium (HP:0009756)5.63616469
3Genetic anticipation (HP:0003743)5.07112061
4Gaze-evoked nystagmus (HP:0000640)4.99218041
5Muscle fiber atrophy (HP:0100295)4.98102166
6Absent/shortened dynein arms (HP:0200106)4.30098526
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.30098526
8Abnormal ciliary motility (HP:0012262)4.23319390
9Progressive cerebellar ataxia (HP:0002073)4.22565089
10Congenital sensorineural hearing impairment (HP:0008527)4.13371510
11Amniotic constriction ring (HP:0009775)4.09270893
12Abnormality of placental membranes (HP:0011409)4.09270893
13Aplasia of the musculature (HP:0100854)4.08794233
14Dysmetric saccades (HP:0000641)4.01252354
15Fetal akinesia sequence (HP:0001989)3.97769053
16Abnormal respiratory motile cilium physiology (HP:0012261)3.94994368
17Abnormality of the neuromuscular junction (HP:0003398)3.93249957
18Fatigable weakness (HP:0003473)3.93249957
19Weak cry (HP:0001612)3.84022951
20Calf muscle hypertrophy (HP:0008981)3.83783577
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.80222347
22Sudden death (HP:0001699)3.60481087
23Severe visual impairment (HP:0001141)3.58206670
24Muscle hypertrophy of the lower extremities (HP:0008968)3.43254968
25Attenuation of retinal blood vessels (HP:0007843)3.40159703
26Atonic seizures (HP:0010819)3.38977498
27Prostate neoplasm (HP:0100787)3.35714021
28Bony spicule pigmentary retinopathy (HP:0007737)3.34256919
29Postural instability (HP:0002172)3.28883981
30Malignant hyperthermia (HP:0002047)3.17760776
31Gowers sign (HP:0003391)3.14813541
32Abnormality of macular pigmentation (HP:0008002)3.13622683
33Retinal dysplasia (HP:0007973)3.09209270
34Aplasia/Hypoplasia involving the musculature (HP:0001460)2.98126655
35Type II lissencephaly (HP:0007260)2.97439324
36Abnormal respiratory motile cilium morphology (HP:0005938)2.83398459
37Abnormal respiratory epithelium morphology (HP:0012253)2.83398459
38Absence seizures (HP:0002121)2.80666883
39Late onset (HP:0003584)2.77031622
40Male infertility (HP:0003251)2.68656678
41Nemaline bodies (HP:0003798)2.63518478
42Asymmetric septal hypertrophy (HP:0001670)2.63038988
43Abnormal auditory evoked potentials (HP:0006958)2.61747176
44Distal arthrogryposis (HP:0005684)2.46511396
45Rhinitis (HP:0012384)2.45166848
46Abnormality of the hepatic vasculature (HP:0006707)2.44549434
47Dialeptic seizures (HP:0011146)2.43283394
48Easy fatigability (HP:0003388)2.41649233
49Horizontal nystagmus (HP:0000666)2.40109263
50Infertility (HP:0000789)2.38578641
51Premature ovarian failure (HP:0008209)2.35578444
52Akinesia (HP:0002304)2.31865610
53Abnormality of the calf musculature (HP:0001430)2.31862885
54Pancreatic fibrosis (HP:0100732)2.30226671
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.29523146
56Facial diplegia (HP:0001349)2.27693375
57Abnormal rod and cone electroretinograms (HP:0008323)2.25929849
58Hypoplastic heart (HP:0001961)2.23841456
59Median cleft lip (HP:0000161)2.21989742
60Action tremor (HP:0002345)2.21007318
61Abnormality of the left ventricular outflow tract (HP:0011103)2.18885273
62Subaortic stenosis (HP:0001682)2.18885273
63Ileus (HP:0002595)2.18829980
64Hypoplasia of the fovea (HP:0007750)2.18197122
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.18197122
66Difficulty walking (HP:0002355)2.15350194
67Clumsiness (HP:0002312)2.13926693
68Limb ataxia (HP:0002070)2.12211579
69Round ear (HP:0100830)2.07827211
70Poor suck (HP:0002033)2.06047982
71Pendular nystagmus (HP:0012043)2.05607791
72Urinary bladder sphincter dysfunction (HP:0002839)2.03226698
73Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.00110776
74Focal seizures (HP:0007359)1.99340641
75Disproportionate short-trunk short stature (HP:0003521)1.98280752
76Absent phalangeal crease (HP:0006109)1.97380137
77Areflexia of lower limbs (HP:0002522)1.97052638
78Hypophosphatemic rickets (HP:0004912)1.95898138
79Dyschromatopsia (HP:0007641)1.95675328
80Abnormal drinking behavior (HP:0030082)1.93884272
81Polydipsia (HP:0001959)1.93884272
82Retinal atrophy (HP:0001105)1.90768497
83Cerebellar dysplasia (HP:0007033)1.85694279
84Prolonged QT interval (HP:0001657)1.82668699
85Facial cleft (HP:0002006)1.79569110
86Impaired smooth pursuit (HP:0007772)1.78843798
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78347809
88Muscle fiber inclusion bodies (HP:0100299)1.76916818
89Tetany (HP:0001281)1.76638995
90Nonprogressive disorder (HP:0003680)1.72482840
91Central scotoma (HP:0000603)1.72410937
92Thin ribs (HP:0000883)1.70002641
93Decreased central vision (HP:0007663)1.69310960
94Febrile seizures (HP:0002373)1.68774976
95Congenital stationary night blindness (HP:0007642)1.68426559
96Bilateral microphthalmos (HP:0007633)1.68345729
97Pterygium (HP:0001059)1.65959270
98Hypoplastic ischia (HP:0003175)1.64712041
99Abnormality of dental color (HP:0011073)1.64357871
100Pancreatic cysts (HP:0001737)1.64159401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.17558180
2CDK194.55194402
3PINK14.32693234
4INSRR4.01238101
5PLK43.32050072
6OXSR13.11627504
7PIK3CG3.06503229
8OBSCN2.65246867
9TLK12.62220980
10ZAK2.51603278
11BMPR1B2.38909012
12STK162.26162706
13PLK22.25298133
14DDR21.95905353
15MARK31.95861531
16STK391.85682997
17STK38L1.82360865
18MYLK1.80655912
19LATS11.67780941
20ACVR1B1.61592748
21ADRBK21.48880936
22MUSK1.45772414
23TNIK1.40626241
24STK381.37912824
25TAOK31.28109633
26GRK11.26892125
27CDK121.18620648
28PRKG21.09132771
29ICK1.05027523
30AURKA1.02994977
31LATS21.00967756
32NUAK11.00214215
33VRK10.93263240
34WNK10.91669862
35TNK20.91279701
36STK30.89581331
37TEC0.89118345
38PTK2B0.85757166
39PKN10.85142530
40MELK0.84010055
41MAP3K70.83250740
42RPS6KA50.78146015
43NEK20.75081034
44CHEK20.69381410
45PRKG10.66643944
46CDK30.66204681
47PDPK10.65432953
48MAP3K90.64917354
49PDK10.64499299
50FER0.62222344
51CSNK1G20.62189025
52LIMK10.58950666
53MARK20.55524240
54CSNK1D0.51588680
55PRKACB0.50393472
56MAP4K20.49738547
57CAMK10.48798815
58ADRBK10.48784660
59PIK3CA0.48630678
60MAPK150.48148450
61MAPK110.47739138
62WNK40.46987612
63NTRK30.46661239
64PRKCG0.44986803
65PRKD30.44569087
66MTOR0.44005021
67PAK10.41886135
68PRKCE0.39450970
69SGK20.38925501
70TGFBR10.37655022
71CAMK2A0.35774220
72PRKACA0.35696548
73MAPK130.34170949
74MST1R0.33206605
75MAPK120.33175855
76CAMK1G0.33052716
77PRKAA20.32929057
78GRK50.30662264
79SGK4940.30442576
80SGK2230.30442576
81TIE10.30233959
82CHEK10.29941060
83PAK20.29929501
84BTK0.29906239
85IGF1R0.29577684
86PRKCA0.29442225
87TXK0.27603004
88MAPK10.27027269
89PRKAA10.26881196
90PBK0.25850175
91ARAF0.24143061
92MAP2K10.23888787
93ROCK10.23725648
94PLK30.23549709
95AURKB0.23423675
96CDK50.23256971
97MAP3K50.23130608
98CDK70.22439197
99PLK10.21658286
100CAMK40.20321589

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.32041240
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.20776087
3Olfactory transduction_Homo sapiens_hsa047402.76471239
4Butanoate metabolism_Homo sapiens_hsa006502.72262580
5Tryptophan metabolism_Homo sapiens_hsa003802.70054973
6Fatty acid biosynthesis_Homo sapiens_hsa000612.61465647
7Retinol metabolism_Homo sapiens_hsa008302.00987593
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.98612217
9Steroid hormone biosynthesis_Homo sapiens_hsa001401.97476253
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91526679
11Nitrogen metabolism_Homo sapiens_hsa009101.90642016
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90131770
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81463864
14Gap junction_Homo sapiens_hsa045401.77380904
15Taste transduction_Homo sapiens_hsa047421.71311204
16Dilated cardiomyopathy_Homo sapiens_hsa054141.66679906
17Dorso-ventral axis formation_Homo sapiens_hsa043201.61633595
18Chemical carcinogenesis_Homo sapiens_hsa052041.56930646
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.55306770
20Circadian rhythm_Homo sapiens_hsa047101.53981726
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47238135
22Salivary secretion_Homo sapiens_hsa049701.44911832
23Bile secretion_Homo sapiens_hsa049761.44721051
24Morphine addiction_Homo sapiens_hsa050321.44514263
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43888082
26Phototransduction_Homo sapiens_hsa047441.41300178
27ABC transporters_Homo sapiens_hsa020101.39880666
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.36666722
29GABAergic synapse_Homo sapiens_hsa047271.35289453
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30813180
31Linoleic acid metabolism_Homo sapiens_hsa005911.27800968
32Nicotine addiction_Homo sapiens_hsa050331.25938557
33Basal transcription factors_Homo sapiens_hsa030221.25090436
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23809772
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23111409
36Circadian entrainment_Homo sapiens_hsa047131.22428337
37Homologous recombination_Homo sapiens_hsa034401.16193036
38RNA polymerase_Homo sapiens_hsa030201.16130712
39Calcium signaling pathway_Homo sapiens_hsa040201.15325961
40Insulin secretion_Homo sapiens_hsa049111.14089696
41Glutathione metabolism_Homo sapiens_hsa004801.12641158
42Oxytocin signaling pathway_Homo sapiens_hsa049211.04728893
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03776452
44Gastric acid secretion_Homo sapiens_hsa049711.03438450
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02577536
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00821246
47Cardiac muscle contraction_Homo sapiens_hsa042600.99827925
48Purine metabolism_Homo sapiens_hsa002300.99673367
49Ovarian steroidogenesis_Homo sapiens_hsa049130.99025663
50Renin secretion_Homo sapiens_hsa049240.98625613
51Serotonergic synapse_Homo sapiens_hsa047260.96962525
52PPAR signaling pathway_Homo sapiens_hsa033200.93406207
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93338120
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93324603
55Selenocompound metabolism_Homo sapiens_hsa004500.91898224
56Glutamatergic synapse_Homo sapiens_hsa047240.91504974
57Glycerolipid metabolism_Homo sapiens_hsa005610.90301172
58Hedgehog signaling pathway_Homo sapiens_hsa043400.88689550
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88150937
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87708262
61Oocyte meiosis_Homo sapiens_hsa041140.84777183
62Cholinergic synapse_Homo sapiens_hsa047250.84240658
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84146797
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82089168
65cAMP signaling pathway_Homo sapiens_hsa040240.81954086
66Propanoate metabolism_Homo sapiens_hsa006400.81203398
67Systemic lupus erythematosus_Homo sapiens_hsa053220.78655629
68Starch and sucrose metabolism_Homo sapiens_hsa005000.76972751
69Fatty acid degradation_Homo sapiens_hsa000710.73302976
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72426853
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72060274
72Caffeine metabolism_Homo sapiens_hsa002320.69748397
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69092250
74Fanconi anemia pathway_Homo sapiens_hsa034600.62952428
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61694067
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60840072
77beta-Alanine metabolism_Homo sapiens_hsa004100.57176635
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54918802
79Tight junction_Homo sapiens_hsa045300.53634727
80Alcoholism_Homo sapiens_hsa050340.53535504
81Arginine and proline metabolism_Homo sapiens_hsa003300.50771898
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.50705428
83Pancreatic secretion_Homo sapiens_hsa049720.49348214
84Platelet activation_Homo sapiens_hsa046110.49301452
85Arachidonic acid metabolism_Homo sapiens_hsa005900.46689929
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44437926
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.42579992
88ECM-receptor interaction_Homo sapiens_hsa045120.41540606
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38290291
90Phagosome_Homo sapiens_hsa041450.37997633
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37515696
92Type II diabetes mellitus_Homo sapiens_hsa049300.36807486
93Fatty acid metabolism_Homo sapiens_hsa012120.35142387
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34760361
95Ether lipid metabolism_Homo sapiens_hsa005650.34242014
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.33683418
97Metabolic pathways_Homo sapiens_hsa011000.33037793
98Sulfur metabolism_Homo sapiens_hsa009200.31750278
99Mineral absorption_Homo sapiens_hsa049780.30217860
100Arginine biosynthesis_Homo sapiens_hsa002200.29251954

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