ZNF702P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to ethanol (GO:0048149)8.57393291
2negative regulation of cAMP-mediated signaling (GO:0043951)8.37994501
3opioid receptor signaling pathway (GO:0038003)8.18830309
4ether lipid metabolic process (GO:0046485)7.71853169
5negative regulation of calcium ion-dependent exocytosis (GO:0045955)7.11865866
6regulation of acrosome reaction (GO:0060046)7.11742725
7adult feeding behavior (GO:0008343)6.99505307
8regulation of protein glycosylation (GO:0060049)6.25965844
9regulation of translational termination (GO:0006449)6.02401761
10piRNA metabolic process (GO:0034587)5.77468388
11sphingosine metabolic process (GO:0006670)5.53463107
12adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.40242657
13positive regulation of cAMP-mediated signaling (GO:0043950)5.36457822
14diol metabolic process (GO:0034311)5.01706970
15sphingoid metabolic process (GO:0046519)4.89886442
16thrombin receptor signaling pathway (GO:0070493)4.63749193
17notochord development (GO:0030903)4.61560734
18glycerol ether metabolic process (GO:0006662)4.57159270
19negative regulation of nitric oxide biosynthetic process (GO:0045019)4.42704370
20ether metabolic process (GO:0018904)4.26654733
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.16281420
22behavioral response to nicotine (GO:0035095)4.03914419
23DNA replication-dependent nucleosome organization (GO:0034723)3.91708031
24DNA replication-dependent nucleosome assembly (GO:0006335)3.91708031
25ncRNA catabolic process (GO:0034661)3.75213109
26pyrimidine dimer repair (GO:0006290)3.68994512
27regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.67390410
28indolalkylamine metabolic process (GO:0006586)3.66388366
29regulation of glutamate receptor signaling pathway (GO:1900449)3.64458164
30cornea development in camera-type eye (GO:0061303)3.59708780
31epithelial cilium movement (GO:0003351)3.42117405
32cellular response to ammonium ion (GO:0071242)3.37386703
33RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31062766
34regulation of cAMP-mediated signaling (GO:0043949)3.26542803
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24672620
36glycerophospholipid catabolic process (GO:0046475)3.21973153
37mRNA cleavage (GO:0006379)3.16384526
38replication fork processing (GO:0031297)3.14120305
39negative regulation of glycoprotein biosynthetic process (GO:0010561)3.14044058
40cellular response to alkaloid (GO:0071312)3.12725654
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12359328
42regulation of calcium ion-dependent exocytosis (GO:0017158)3.08675622
43cilium morphogenesis (GO:0060271)3.07444062
44regulation of rhodopsin mediated signaling pathway (GO:0022400)3.03549860
45negative regulation of adenylate cyclase activity (GO:0007194)2.99639962
46protein localization to synapse (GO:0035418)2.99471752
47spermatid development (GO:0007286)2.98814753
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98430517
49regulation of memory T cell differentiation (GO:0043380)2.96070797
50neuronal action potential (GO:0019228)2.92887147
51preassembly of GPI anchor in ER membrane (GO:0016254)2.92756593
52DNA deamination (GO:0045006)2.92427198
53thyroid hormone metabolic process (GO:0042403)2.91667222
54transmission of nerve impulse (GO:0019226)2.90465387
55thyroid hormone generation (GO:0006590)2.89576739
56fucose catabolic process (GO:0019317)2.89292742
57L-fucose metabolic process (GO:0042354)2.89292742
58L-fucose catabolic process (GO:0042355)2.89292742
59left/right axis specification (GO:0070986)2.88069993
60negative regulation of cyclase activity (GO:0031280)2.79412147
61wound healing, spreading of epidermal cells (GO:0035313)2.78218202
62resolution of meiotic recombination intermediates (GO:0000712)2.78132229
63rhodopsin mediated signaling pathway (GO:0016056)2.77526448
64photoreceptor cell maintenance (GO:0045494)2.77475463
65detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.75450227
66positive regulation of cardiac muscle cell differentiation (GO:2000727)2.75378101
67negative regulation of lyase activity (GO:0051350)2.74387465
68coenzyme catabolic process (GO:0009109)2.73756275
69response to pheromone (GO:0019236)2.73479103
70glycosphingolipid metabolic process (GO:0006687)2.73330241
71retinal cone cell development (GO:0046549)2.71791613
72regulation of translational elongation (GO:0006448)2.66927126
73indole-containing compound catabolic process (GO:0042436)2.65686752
74indolalkylamine catabolic process (GO:0046218)2.65686752
75tryptophan catabolic process (GO:0006569)2.65686752
76vitamin catabolic process (GO:0009111)2.65453625
77fat-soluble vitamin catabolic process (GO:0042363)2.65453625
78ribonucleoprotein complex disassembly (GO:0032988)2.64554889
79positive regulation of fatty acid transport (GO:2000193)2.63747838
80indole-containing compound metabolic process (GO:0042430)2.63313919
81membrane depolarization during action potential (GO:0086010)2.63213059
82reflex (GO:0060004)2.61910132
83glomerular visceral epithelial cell development (GO:0072015)2.59619930
84regulation of meiosis I (GO:0060631)2.59122360
85cellular ketone body metabolic process (GO:0046950)2.56130902
86glycolipid metabolic process (GO:0006664)2.53107344
87cilium movement (GO:0003341)2.52972616
88membrane lipid metabolic process (GO:0006643)2.49847928
89kynurenine metabolic process (GO:0070189)2.47388666
90regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.46726360
91quinone biosynthetic process (GO:1901663)2.46581620
92gene silencing by RNA (GO:0031047)2.45376298
93axoneme assembly (GO:0035082)2.41356571
94GPI anchor metabolic process (GO:0006505)2.41324677
95regulation of hippo signaling (GO:0035330)2.40916265
96negative regulation of cAMP biosynthetic process (GO:0030818)2.40913334
97positive regulation of icosanoid secretion (GO:0032305)2.40852596
98glyoxylate metabolic process (GO:0046487)2.39889793
99dopamine transport (GO:0015872)2.39154849
100negative regulation of cytosolic calcium ion concentration (GO:0051481)11.3839143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.42982543
2VDR_22108803_ChIP-Seq_LS180_Human3.33912883
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09933532
4GBX2_23144817_ChIP-Seq_PC3_Human3.05292016
5TAF15_26573619_Chip-Seq_HEK293_Human2.93437193
6IGF1R_20145208_ChIP-Seq_DFB_Human2.61533283
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56169235
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48277104
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44862108
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32559565
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21311597
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.19537018
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.16632471
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16632471
15P300_19829295_ChIP-Seq_ESCs_Human2.13884773
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10292154
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08828117
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.04116826
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01914118
20FUS_26573619_Chip-Seq_HEK293_Human2.00483545
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99713598
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99252626
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89550644
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79291872
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78147550
26SOX2_19829295_ChIP-Seq_ESCs_Human1.75797023
27NANOG_19829295_ChIP-Seq_ESCs_Human1.75797023
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72855222
29BCAT_22108803_ChIP-Seq_LS180_Human1.71523038
30IRF1_19129219_ChIP-ChIP_H3396_Human1.69883321
31EWS_26573619_Chip-Seq_HEK293_Human1.68347616
32STAT3_23295773_ChIP-Seq_U87_Human1.67868452
33RXR_22108803_ChIP-Seq_LS180_Human1.65988422
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.65157301
35EZH2_22144423_ChIP-Seq_EOC_Human1.64323959
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62819773
37* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61955082
38* CBP_20019798_ChIP-Seq_JUKART_Human1.61955082
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61582237
40SMAD4_21799915_ChIP-Seq_A2780_Human1.61489657
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58166284
42TCF4_23295773_ChIP-Seq_U87_Human1.57191012
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56997160
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.54864045
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52607334
46ER_23166858_ChIP-Seq_MCF-7_Human1.52535333
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51057559
48AR_25329375_ChIP-Seq_VCAP_Human1.46683098
49HTT_18923047_ChIP-ChIP_STHdh_Human1.44234947
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43735910
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.40708472
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.40657799
53TCF4_22108803_ChIP-Seq_LS180_Human1.33455540
54TP53_22573176_ChIP-Seq_HFKS_Human1.32124957
55CDX2_22108803_ChIP-Seq_LS180_Human1.30407637
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29207006
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28095400
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27961163
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.27814193
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27067324
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27011333
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26933256
63TP53_18474530_ChIP-ChIP_U2OS_Human1.26658550
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25695933
65RUNX2_22187159_ChIP-Seq_PCA_Human1.23693649
66RNF2_27304074_Chip-Seq_NSC_Mouse1.23528440
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20965637
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20894135
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20561674
70* SMAD4_21741376_ChIP-Seq_EPCs_Human1.19741220
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19555699
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18587280
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.14438607
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13553766
75TP53_16413492_ChIP-PET_HCT116_Human1.13370571
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.13222442
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13118234
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.12912946
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.12879465
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11144889
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.09799107
82SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07437571
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06852765
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06222675
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05686454
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05175233
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03713346
88P53_22387025_ChIP-Seq_ESCs_Mouse1.02645655
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01871333
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01408769
91KDM2B_26808549_Chip-Seq_REH_Human1.01251304
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01115458
93REST_21632747_ChIP-Seq_MESCs_Mouse1.00998449
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.00762276
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00521434
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00189436
97P300_18555785_Chip-Seq_ESCs_Mouse1.00124607
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99975457
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.99513140
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98775929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.44483578
2MP0002876_abnormal_thyroid_physiology4.28366598
3MP0003880_abnormal_central_pattern3.99115494
4MP0001968_abnormal_touch/_nociception3.80538974
5MP0009278_abnormal_bone_marrow3.29550748
6MP0005551_abnormal_eye_electrophysiolog2.75123406
7MP0003941_abnormal_skin_development2.72670639
8MP0005360_urolithiasis2.47894105
9MP0002102_abnormal_ear_morphology2.45962412
10MP0003195_calcinosis2.39248701
11MP0005646_abnormal_pituitary_gland2.17295553
12MP0001501_abnormal_sleep_pattern2.01935406
13MP0009046_muscle_twitch1.94746098
14MP0008877_abnormal_DNA_methylation1.82761875
15MP0005645_abnormal_hypothalamus_physiol1.80706123
16MP0005503_abnormal_tendon_morphology1.77935735
17MP0009745_abnormal_behavioral_response1.71148888
18MP0006276_abnormal_autonomic_nervous1.70093727
19MP0003890_abnormal_embryonic-extraembry1.65226690
20MP0006072_abnormal_retinal_apoptosis1.64860051
21MP0002638_abnormal_pupillary_reflex1.60441350
22MP0009764_decreased_sensitivity_to1.59958962
23MP0003950_abnormal_plasma_membrane1.55950994
24MP0004147_increased_porphyrin_level1.55005550
25MP0002272_abnormal_nervous_system1.54613294
26MP0001486_abnormal_startle_reflex1.51974813
27MP0001664_abnormal_digestion1.47755230
28MP0000678_abnormal_parathyroid_gland1.47717489
29MP0006035_abnormal_mitochondrial_morpho1.47567773
30MP0004145_abnormal_muscle_electrophysio1.47249822
31MP0006292_abnormal_olfactory_placode1.46958400
32MP0008872_abnormal_physiological_respon1.45270349
33MP0002733_abnormal_thermal_nociception1.44441466
34MP0003937_abnormal_limbs/digits/tail_de1.43869368
35MP0000681_abnormal_thyroid_gland1.41772947
36MP0003633_abnormal_nervous_system1.30138321
37MP0000778_abnormal_nervous_system1.26288226
38MP0003787_abnormal_imprinting1.24506088
39MP0000049_abnormal_middle_ear1.23961450
40MP0001485_abnormal_pinna_reflex1.22241535
41MP0003567_abnormal_fetal_cardiomyocyte1.22102403
42MP0005253_abnormal_eye_physiology1.21680701
43MP0001529_abnormal_vocalization1.19244123
44MP0002557_abnormal_social/conspecific_i1.17924165
45MP0005195_abnormal_posterior_eye1.16379593
46MP0005397_hematopoietic_system_phenotyp1.15806931
47MP0001545_abnormal_hematopoietic_system1.15806931
48MP0008775_abnormal_heart_ventricle1.12611241
49MP0006054_spinal_hemorrhage1.08044080
50MP0002736_abnormal_nociception_after1.07155355
51MP0001970_abnormal_pain_threshold1.05356356
52MP0000427_abnormal_hair_cycle1.04212205
53MP0002249_abnormal_larynx_morphology1.04108965
54MP0008789_abnormal_olfactory_epithelium1.03388418
55MP0008875_abnormal_xenobiotic_pharmacok1.01251480
56MP0003718_maternal_effect1.00856542
57MP0010234_abnormal_vibrissa_follicle0.97922912
58MP0004782_abnormal_surfactant_physiolog0.97576780
59MP0000230_abnormal_systemic_arterial0.96872819
60MP0010678_abnormal_skin_adnexa0.95564248
61MP0004133_heterotaxia0.95349644
62MP0003638_abnormal_response/metabolism_0.95153744
63MP0002572_abnormal_emotion/affect_behav0.94320461
64MP0003646_muscle_fatigue0.92744152
65MP0005389_reproductive_system_phenotype0.92174826
66MP0003183_abnormal_peptide_metabolism0.91847128
67MP0005167_abnormal_blood-brain_barrier0.91049257
68MP0002752_abnormal_somatic_nervous0.90653378
69MP0004085_abnormal_heartbeat0.90377728
70MP0002067_abnormal_sensory_capabilities0.90039343
71MP0003959_abnormal_lean_body0.86698767
72MP0001177_atelectasis0.85456543
73MP0003635_abnormal_synaptic_transmissio0.83499893
74MP0000516_abnormal_urinary_system0.83245757
75MP0005367_renal/urinary_system_phenotyp0.83245757
76MP0000569_abnormal_digit_pigmentation0.82772333
77MP0002938_white_spotting0.82179653
78MP0001963_abnormal_hearing_physiology0.80731812
79MP0003045_fibrosis0.80348706
80MP0004142_abnormal_muscle_tone0.80284150
81MP0002063_abnormal_learning/memory/cond0.80152957
82MP0003755_abnormal_palate_morphology0.80143089
83MP0002837_dystrophic_cardiac_calcinosis0.79978421
84MP0000631_abnormal_neuroendocrine_gland0.79940608
85MP0002160_abnormal_reproductive_system0.79636953
86MP0001919_abnormal_reproductive_system0.79374929
87MP0005394_taste/olfaction_phenotype0.78958978
88MP0005499_abnormal_olfactory_system0.78958978
89MP0002064_seizures0.78185077
90MP0003938_abnormal_ear_development0.78030122
91MP0003631_nervous_system_phenotype0.76259235
92MP0004084_abnormal_cardiac_muscle0.76089306
93MP0000383_abnormal_hair_follicle0.75982928
94MP0002234_abnormal_pharynx_morphology0.75882272
95MP0004924_abnormal_behavior0.75731440
96MP0005386_behavior/neurological_phenoty0.75731440
97MP0001986_abnormal_taste_sensitivity0.75259261
98MP0002229_neurodegeneration0.74798523
99MP0003119_abnormal_digestive_system0.73839259
100MP0002138_abnormal_hepatobiliary_system0.73563022

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)9.63996568
2Intestinal atresia (HP:0011100)5.83416186
3Volvulus (HP:0002580)5.36286664
4Pancreatic islet-cell hyperplasia (HP:0004510)4.45299682
5Abnormality of the aortic arch (HP:0012303)4.35755728
6Large for gestational age (HP:0001520)4.15398329
7Broad alveolar ridges (HP:0000187)4.13641084
8Type II lissencephaly (HP:0007260)3.87539466
9Thickened helices (HP:0000391)3.70251820
10Abnormality of the ileum (HP:0001549)3.67863185
11Agitation (HP:0000713)3.62851378
12Poor head control (HP:0002421)3.59613602
13Tubular atrophy (HP:0000092)3.59579005
14Focal motor seizures (HP:0011153)3.59513814
15Gaze-evoked nystagmus (HP:0000640)3.46078826
16Cerebellar dysplasia (HP:0007033)3.31996137
17Pancreatic cysts (HP:0001737)3.16063434
18Gastrointestinal atresia (HP:0002589)3.09576321
19Optic nerve hypoplasia (HP:0000609)3.09306268
20Pancreatic fibrosis (HP:0100732)3.04563835
21Congenital stationary night blindness (HP:0007642)3.02487281
22Lissencephaly (HP:0001339)3.01886876
23Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.91592830
24Abnormality of the pancreatic islet cells (HP:0006476)2.88185803
25Abnormality of endocrine pancreas physiology (HP:0012093)2.88185803
26Mesangial abnormality (HP:0001966)2.78414156
27Abnormality of macular pigmentation (HP:0008002)2.75270046
28True hermaphroditism (HP:0010459)2.75152015
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73363187
30Congenital ichthyosiform erythroderma (HP:0007431)2.69900661
31Oligodontia (HP:0000677)2.69161762
32Molar tooth sign on MRI (HP:0002419)2.68816526
33Abnormality of midbrain morphology (HP:0002418)2.68816526
34Progressive inability to walk (HP:0002505)2.67815105
35Broad-based gait (HP:0002136)2.66947261
36Hyperventilation (HP:0002883)2.61188963
37Chromsome breakage (HP:0040012)2.48815345
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.45258411
39Abnormality of the renal cortex (HP:0011035)2.44064044
40Attenuation of retinal blood vessels (HP:0007843)2.38718165
41Pendular nystagmus (HP:0012043)2.38688579
42Tented upper lip vermilion (HP:0010804)2.38168568
43Focal seizures (HP:0007359)2.35858493
44Nephronophthisis (HP:0000090)2.33970821
45Long nose (HP:0003189)2.33336644
46Medial flaring of the eyebrow (HP:0010747)2.33180482
47Keratoconus (HP:0000563)2.31450589
48Increased corneal curvature (HP:0100692)2.31450589
49Neonatal respiratory distress (HP:0002643)2.27806611
50Inability to walk (HP:0002540)2.26178390
51Abnormality of the renal medulla (HP:0100957)2.17223340
523-Methylglutaconic aciduria (HP:0003535)2.15608931
53Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14739537
54Hypoplasia of the brainstem (HP:0002365)2.14739537
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.07214651
56Hypoproteinemia (HP:0003075)2.04783349
57Meckel diverticulum (HP:0002245)2.04124261
58Abolished electroretinogram (ERG) (HP:0000550)2.03666314
59Disproportionate short-trunk short stature (HP:0003521)2.01253511
60Chronic hepatic failure (HP:0100626)1.98689845
61Dialeptic seizures (HP:0011146)1.96167691
62Cystic liver disease (HP:0006706)1.95105240
63Abnormality of the vitreous humor (HP:0004327)1.94590539
64High anterior hairline (HP:0009890)1.94063684
65Dandy-Walker malformation (HP:0001305)1.93187307
66Large eyes (HP:0001090)1.92096871
67Genital tract atresia (HP:0001827)1.92088076
68Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.91457356
69Gait imbalance (HP:0002141)1.88660252
70Hyperpituitarism (HP:0010514)1.88010670
71Congenital primary aphakia (HP:0007707)1.87605596
72Renal cortical cysts (HP:0000803)1.86778382
73Retinal dysplasia (HP:0007973)1.85534925
74Nephrogenic diabetes insipidus (HP:0009806)1.85193025
75Goiter (HP:0000853)1.84377883
76Vaginal atresia (HP:0000148)1.83864002
77Poor speech (HP:0002465)1.83159179
78Abnormal drinking behavior (HP:0030082)1.82502874
79Polydipsia (HP:0001959)1.82502874
80Abnormality of the alveolar ridges (HP:0006477)1.82151009
81Nephroblastoma (Wilms tumor) (HP:0002667)1.81475167
82Embryonal renal neoplasm (HP:0011794)1.79416373
83Abnormal rod and cone electroretinograms (HP:0008323)1.78931433
84Amblyopia (HP:0000646)1.78020347
85Generalized tonic-clonic seizures (HP:0002069)1.76878764
86Central scotoma (HP:0000603)1.76743870
87Sclerocornea (HP:0000647)1.76388986
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76065575
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.75532648
90Bony spicule pigmentary retinopathy (HP:0007737)1.72702942
91Restlessness (HP:0000711)1.71806419
92Amelogenesis imperfecta (HP:0000705)1.70901422
93Abnormality of chromosome stability (HP:0003220)1.68364926
94Postaxial foot polydactyly (HP:0001830)1.66572774
95Pachygyria (HP:0001302)1.66205175
96Scotoma (HP:0000575)1.65422777
97Hypoplasia of the pons (HP:0012110)1.60987062
98Dysdiadochokinesis (HP:0002075)1.60116301
99Abnormality of the pons (HP:0007361)1.59919078
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.59113877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK27.73928769
2FRK5.95697888
3PINK13.37800705
4BMPR1B2.73020453
5TRIM282.37468879
6PNCK2.19993506
7ADRBK12.19654587
8MAP4K22.04694287
9GRK12.00917872
10CASK1.94343720
11ACVR1B1.91957913
12NUAK11.80269174
13PLK21.78654165
14WNK31.75520594
15PRKCE1.69702381
16PRKCG1.61667047
17TGFBR11.60093071
18TIE11.56117992
19ZAK1.54417411
20BCR1.49885453
21MST41.35580211
22OXSR11.35530444
23IRAK11.33503047
24MAP3K41.32289222
25STK38L1.31751078
26STK391.24209459
27MAP2K71.09705312
28DYRK31.08462918
29EIF2AK31.07752672
30STK31.04645798
31MAPK131.02342652
32FLT31.01653669
33MKNK21.00365351
34WNK40.97839352
35ERN10.92626474
36INSRR0.82284830
37PAK30.81852902
38EPHA40.81157779
39PLK40.80758616
40MKNK10.80747408
41CAMK2A0.79476588
42CSNK1G10.79327510
43CSNK1G30.78659043
44CLK10.78294135
45WEE10.73377299
46PIK3CA0.73165691
47CSNK1G20.72627936
48CSNK1A1L0.70368308
49BCKDK0.68964501
50BRSK20.67694071
51FGFR20.67337303
52PRKCI0.64716505
53PLK30.61534157
54FER0.61373870
55PTK2B0.60349518
56MARK10.59446376
57NTRK20.59290204
58PKN10.58901710
59IRAK30.56901804
60ERBB20.56381152
61MET0.55664145
62GRK70.55340035
63PBK0.52872392
64TNIK0.51707644
65CAMK10.48107653
66NEK20.47889987
67DYRK20.46344263
68ERBB30.44762728
69DAPK20.43777310
70STK380.42940891
71TYRO30.42913602
72MAPKAPK30.40324938
73OBSCN0.39454794
74CSNK1A10.39164796
75VRK10.38125153
76MAPK110.36422486
77TLK10.34457526
78AKT30.33801977
79LATS10.32386947
80EPHB20.32349817
81PRKCA0.32203061
82MAPKAPK50.31944558
83ATM0.30253513
84NEK90.29732710
85PRKCB0.29139557
86PLK10.28968491
87DYRK1A0.27646396
88PRKACA0.27207374
89FGFR10.27167587
90PKN20.26960889
91CSNK1E0.26601609
92BRSK10.25449769
93TEC0.24368000
94CSNK1D0.24047266
95PHKG20.23895844
96PHKG10.23895844
97MAP3K120.23180925
98PAK60.23026940
99SRPK10.22935914
100MINK10.21814002

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.47699250
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.13882018
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68215868
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54674621
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50575439
6Olfactory transduction_Homo sapiens_hsa047402.45104028
7Fanconi anemia pathway_Homo sapiens_hsa034602.31747507
8Dorso-ventral axis formation_Homo sapiens_hsa043202.30359050
9Butanoate metabolism_Homo sapiens_hsa006502.25515424
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.24490432
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20995117
12Linoleic acid metabolism_Homo sapiens_hsa005912.13013878
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12142887
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10562947
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.04911074
16Tryptophan metabolism_Homo sapiens_hsa003801.99635120
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.88154924
18Nitrogen metabolism_Homo sapiens_hsa009101.83252856
19Sphingolipid metabolism_Homo sapiens_hsa006001.81066003
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78633614
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76952755
22Morphine addiction_Homo sapiens_hsa050321.72399107
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63214850
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59491725
25ABC transporters_Homo sapiens_hsa020101.58344678
26Basal transcription factors_Homo sapiens_hsa030221.56269833
27Nicotine addiction_Homo sapiens_hsa050331.52603902
28Ether lipid metabolism_Homo sapiens_hsa005651.50985256
29Protein export_Homo sapiens_hsa030601.50498484
30Propanoate metabolism_Homo sapiens_hsa006401.48511643
31Taste transduction_Homo sapiens_hsa047421.46933521
32Caffeine metabolism_Homo sapiens_hsa002321.43066104
33Ovarian steroidogenesis_Homo sapiens_hsa049131.39963302
34Homologous recombination_Homo sapiens_hsa034401.29256132
35Glycerolipid metabolism_Homo sapiens_hsa005611.26829571
36Selenocompound metabolism_Homo sapiens_hsa004501.18838491
37RNA degradation_Homo sapiens_hsa030181.16072507
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.15227730
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.14486623
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09169719
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08804777
42Arachidonic acid metabolism_Homo sapiens_hsa005901.08560930
43Peroxisome_Homo sapiens_hsa041461.04537148
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.99465492
45Steroid biosynthesis_Homo sapiens_hsa001000.89591098
46Retinol metabolism_Homo sapiens_hsa008300.89518503
47Non-homologous end-joining_Homo sapiens_hsa034500.86159617
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.82004134
49Chemical carcinogenesis_Homo sapiens_hsa052040.81780932
50Oxidative phosphorylation_Homo sapiens_hsa001900.81261969
51Fatty acid degradation_Homo sapiens_hsa000710.79518415
52Salivary secretion_Homo sapiens_hsa049700.78426353
53Glutamatergic synapse_Homo sapiens_hsa047240.76424016
54Circadian entrainment_Homo sapiens_hsa047130.76169376
55RNA polymerase_Homo sapiens_hsa030200.75113342
56Metabolic pathways_Homo sapiens_hsa011000.75009013
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73299656
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71770806
59Mineral absorption_Homo sapiens_hsa049780.71743980
60Cardiac muscle contraction_Homo sapiens_hsa042600.70835329
61Serotonergic synapse_Homo sapiens_hsa047260.70457945
62Hedgehog signaling pathway_Homo sapiens_hsa043400.68817747
63Sulfur relay system_Homo sapiens_hsa041220.63786284
64GABAergic synapse_Homo sapiens_hsa047270.63428530
65beta-Alanine metabolism_Homo sapiens_hsa004100.62846012
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62740283
67Insulin secretion_Homo sapiens_hsa049110.61167585
68Glutathione metabolism_Homo sapiens_hsa004800.60771516
69Calcium signaling pathway_Homo sapiens_hsa040200.59073330
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57477007
71Starch and sucrose metabolism_Homo sapiens_hsa005000.57385421
72Purine metabolism_Homo sapiens_hsa002300.56482752
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56194043
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55769223
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.54853809
76Hippo signaling pathway_Homo sapiens_hsa043900.54619253
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54445630
78Proteasome_Homo sapiens_hsa030500.51954886
79One carbon pool by folate_Homo sapiens_hsa006700.49368198
80Parkinsons disease_Homo sapiens_hsa050120.48320597
81Collecting duct acid secretion_Homo sapiens_hsa049660.48216457
82Huntingtons disease_Homo sapiens_hsa050160.48112991
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.44868895
84Axon guidance_Homo sapiens_hsa043600.44556890
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43532279
86Basal cell carcinoma_Homo sapiens_hsa052170.41965513
87Regulation of autophagy_Homo sapiens_hsa041400.40049005
88Long-term depression_Homo sapiens_hsa047300.39254889
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38748988
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.38504906
91RNA transport_Homo sapiens_hsa030130.36337902
92Arginine and proline metabolism_Homo sapiens_hsa003300.34319103
93TGF-beta signaling pathway_Homo sapiens_hsa043500.33137636
94Nucleotide excision repair_Homo sapiens_hsa034200.31055074
95Alzheimers disease_Homo sapiens_hsa050100.30794482
96Pyrimidine metabolism_Homo sapiens_hsa002400.30525447
97p53 signaling pathway_Homo sapiens_hsa041150.28792474
98Histidine metabolism_Homo sapiens_hsa003400.28783412
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27387146
100Fat digestion and absorption_Homo sapiens_hsa049750.26972859

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