ZNF70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.10201112
2fucose catabolic process (GO:0019317)4.20841007
3L-fucose metabolic process (GO:0042354)4.20841007
4L-fucose catabolic process (GO:0042355)4.20841007
5DNA deamination (GO:0045006)3.92850511
6sulfation (GO:0051923)3.90746290
7kynurenine metabolic process (GO:0070189)3.89634814
8indole-containing compound catabolic process (GO:0042436)3.82569325
9indolalkylamine catabolic process (GO:0046218)3.82569325
10tryptophan catabolic process (GO:0006569)3.82569325
11gamma-aminobutyric acid transport (GO:0015812)3.73298713
12cellular response to ATP (GO:0071318)3.65862158
13negative regulation of mast cell activation (GO:0033004)3.64935389
14indolalkylamine metabolic process (GO:0006586)3.59492206
15negative regulation of telomere maintenance (GO:0032205)3.46766267
16kidney morphogenesis (GO:0060993)3.42416118
17water-soluble vitamin biosynthetic process (GO:0042364)3.34638140
18response to pheromone (GO:0019236)3.28401059
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27737554
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23986781
21neuronal action potential (GO:0019228)3.21548575
22tryptophan metabolic process (GO:0006568)3.20929139
23detection of light stimulus involved in sensory perception (GO:0050962)3.15127947
24detection of light stimulus involved in visual perception (GO:0050908)3.15127947
25negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11794510
26regulation of hippo signaling (GO:0035330)3.07129754
27somite development (GO:0061053)3.06736685
28platelet dense granule organization (GO:0060155)3.06674886
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.05394942
30NADH dehydrogenase complex assembly (GO:0010257)3.05394942
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05394942
32regulation of gene silencing by RNA (GO:0060966)3.04231136
33regulation of posttranscriptional gene silencing (GO:0060147)3.04231136
34regulation of gene silencing by miRNA (GO:0060964)3.04231136
35reflex (GO:0060004)3.03487559
36primary amino compound metabolic process (GO:1901160)3.02846898
37indole-containing compound metabolic process (GO:0042430)3.02193185
38protein polyglutamylation (GO:0018095)3.02106444
39regulation of action potential (GO:0098900)3.01597708
40nephron tubule morphogenesis (GO:0072078)3.00226572
41nephron epithelium morphogenesis (GO:0072088)3.00226572
42piRNA metabolic process (GO:0034587)2.99705501
43peristalsis (GO:0030432)2.94175877
44preassembly of GPI anchor in ER membrane (GO:0016254)2.93918588
45cornea development in camera-type eye (GO:0061303)2.93278384
46serotonin metabolic process (GO:0042428)2.92706465
47nonmotile primary cilium assembly (GO:0035058)2.87288289
48regulation of mesoderm development (GO:2000380)2.86106646
49protein complex biogenesis (GO:0070271)2.85919232
50ubiquinone biosynthetic process (GO:0006744)2.82486805
51cellular ketone body metabolic process (GO:0046950)2.80216695
52epithelial cilium movement (GO:0003351)2.78486830
53spinal cord motor neuron differentiation (GO:0021522)2.75879847
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.75246150
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.75246150
56regulation of translation, ncRNA-mediated (GO:0045974)2.75246150
57mitochondrial respiratory chain complex assembly (GO:0033108)2.74715343
58endoderm formation (GO:0001706)2.74360307
59negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73636904
60protein-cofactor linkage (GO:0018065)2.70118787
61amine catabolic process (GO:0009310)2.70089474
62cellular biogenic amine catabolic process (GO:0042402)2.70089474
63positive regulation of fatty acid beta-oxidation (GO:0032000)2.69797845
64ubiquinone metabolic process (GO:0006743)2.66944959
65positive regulation of fatty acid oxidation (GO:0046321)2.65301760
66reciprocal DNA recombination (GO:0035825)2.64798400
67reciprocal meiotic recombination (GO:0007131)2.64798400
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63637828
69cell proliferation in forebrain (GO:0021846)2.62350371
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62064809
71negative regulation of multicellular organism growth (GO:0040015)2.61195088
72protein import into peroxisome matrix (GO:0016558)2.61099652
73rhodopsin mediated signaling pathway (GO:0016056)2.59747843
74phasic smooth muscle contraction (GO:0014821)2.59296260
75neural tube formation (GO:0001841)2.59054202
76negative regulation of systemic arterial blood pressure (GO:0003085)2.58848171
77purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.57608020
783-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.57608020
79positive regulation of fatty acid transport (GO:2000193)2.56521253
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.55747982
81positive regulation of defense response to virus by host (GO:0002230)2.55211726
82behavioral response to ethanol (GO:0048149)2.54596261
83axoneme assembly (GO:0035082)2.53920070
84male meiosis I (GO:0007141)2.53600094
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52681483
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51005490
87regulation of telomere maintenance (GO:0032204)2.50895934
88pseudouridine synthesis (GO:0001522)2.50304138
89ketone body metabolic process (GO:1902224)2.49186223
90recombinational repair (GO:0000725)2.47648111
91head development (GO:0060322)2.46751031
92cilium morphogenesis (GO:0060271)2.46479112
93somite rostral/caudal axis specification (GO:0032525)2.46460372
94double-strand break repair via homologous recombination (GO:0000724)2.44871386
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44005031
96regulation of glucokinase activity (GO:0033131)2.43452914
97regulation of hexokinase activity (GO:1903299)2.43452914
98renal tubule morphogenesis (GO:0061333)2.41607978
99DNA methylation involved in gamete generation (GO:0043046)2.41429756
100cellular response to exogenous dsRNA (GO:0071360)2.41262172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.14339845
2EZH2_22144423_ChIP-Seq_EOC_Human3.49866557
3VDR_22108803_ChIP-Seq_LS180_Human3.42454927
4GBX2_23144817_ChIP-Seq_PC3_Human2.87583828
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84813038
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71328243
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46523049
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40064042
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14767328
10IGF1R_20145208_ChIP-Seq_DFB_Human2.13343199
11EWS_26573619_Chip-Seq_HEK293_Human2.11871209
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00502938
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99223265
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99216143
15TAF15_26573619_Chip-Seq_HEK293_Human1.94600161
16FUS_26573619_Chip-Seq_HEK293_Human1.91434846
17ER_23166858_ChIP-Seq_MCF-7_Human1.91344769
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85871921
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85838602
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80308159
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.77947016
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.76777947
23P300_19829295_ChIP-Seq_ESCs_Human1.71624248
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.71111511
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70265015
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.68736326
27IRF1_19129219_ChIP-ChIP_H3396_Human1.67018305
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59331077
29BCAT_22108803_ChIP-Seq_LS180_Human1.58139662
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57082098
31STAT3_23295773_ChIP-Seq_U87_Human1.52834827
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52707363
33MYC_18940864_ChIP-ChIP_HL60_Human1.49741866
34TP53_22573176_ChIP-Seq_HFKS_Human1.48625412
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48482786
36REST_21632747_ChIP-Seq_MESCs_Mouse1.47349682
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.47044423
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.47029842
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43965718
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43579511
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43013177
42TCF4_23295773_ChIP-Seq_U87_Human1.41854155
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39210711
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39210711
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.38051202
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38051202
47AR_25329375_ChIP-Seq_VCAP_Human1.37942890
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37380813
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35425404
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.34173098
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34134457
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31706990
53CBP_20019798_ChIP-Seq_JUKART_Human1.31706990
54AR_21572438_ChIP-Seq_LNCaP_Human1.31178470
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.30596587
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29494497
57RNF2_27304074_Chip-Seq_NSC_Mouse1.28017880
58SMAD4_21799915_ChIP-Seq_A2780_Human1.27826015
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25785575
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.23831407
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23246943
62SOX2_19829295_ChIP-Seq_ESCs_Human1.22462274
63NANOG_19829295_ChIP-Seq_ESCs_Human1.22462274
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22080868
65NCOR_22424771_ChIP-Seq_293T_Human1.20608365
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20178798
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.19262470
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.17110735
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.16949228
70TCF4_22108803_ChIP-Seq_LS180_Human1.15728109
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15086497
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13248283
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12718230
74RUNX2_22187159_ChIP-Seq_PCA_Human1.11765539
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11347488
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.10927341
77TP53_16413492_ChIP-PET_HCT116_Human1.10433989
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10041194
79AR_20517297_ChIP-Seq_VCAP_Human1.09501442
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08646495
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.08567161
82HOXB7_26014856_ChIP-Seq_BT474_Human1.08505358
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07308269
84DROSHA_22980978_ChIP-Seq_HELA_Human1.07288910
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06820930
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05920089
87* ERA_21632823_ChIP-Seq_H3396_Human1.05859174
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.02219390
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02106535
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01264807
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00409487
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98717099
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98251273
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.97496240
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96887847
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96218766
97SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95810361
98TAF2_19829295_ChIP-Seq_ESCs_Human0.95585276
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.94620466
100EST1_17652178_ChIP-ChIP_JURKAT_Human0.93452619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis2.98605301
2MP0003646_muscle_fatigue2.71776371
3MP0002102_abnormal_ear_morphology2.52015794
4MP0008877_abnormal_DNA_methylation2.39843602
5MP0003283_abnormal_digestive_organ2.35978128
6MP0005551_abnormal_eye_electrophysiolog2.33733946
7MP0000569_abnormal_digit_pigmentation2.33665825
8MP0001968_abnormal_touch/_nociception2.30100270
9MP0009046_muscle_twitch2.29699044
10MP0001986_abnormal_taste_sensitivity2.22323298
11MP0002837_dystrophic_cardiac_calcinosis2.06708775
12MP0003136_yellow_coat_color2.06304377
13MP0005646_abnormal_pituitary_gland2.04293973
14MP0008872_abnormal_physiological_respon2.03691536
15MP0002876_abnormal_thyroid_physiology2.02683119
16MP0004147_increased_porphyrin_level2.00155723
17MP0006292_abnormal_olfactory_placode1.99621756
18MP0004133_heterotaxia1.95682354
19MP0004885_abnormal_endolymph1.95386013
20MP0002638_abnormal_pupillary_reflex1.92559763
21MP0009745_abnormal_behavioral_response1.88667662
22MP0002735_abnormal_chemical_nociception1.84478986
23MP0004043_abnormal_pH_regulation1.80187428
24MP0003011_delayed_dark_adaptation1.79592811
25MP0002653_abnormal_ependyma_morphology1.79249640
26MP0005645_abnormal_hypothalamus_physiol1.77864920
27MP0004142_abnormal_muscle_tone1.76127696
28MP0002736_abnormal_nociception_after1.74269446
29MP0001485_abnormal_pinna_reflex1.71029546
30MP0002160_abnormal_reproductive_system1.68944133
31MP0004145_abnormal_muscle_electrophysio1.65546817
32MP0002272_abnormal_nervous_system1.65468887
33MP0006072_abnormal_retinal_apoptosis1.65085674
34MP0000631_abnormal_neuroendocrine_gland1.64500971
35MP0003890_abnormal_embryonic-extraembry1.61297067
36MP0005253_abnormal_eye_physiology1.60421080
37MP0002938_white_spotting1.59593982
38MP0005174_abnormal_tail_pigmentation1.59171630
39MP0000427_abnormal_hair_cycle1.54286409
40MP0008875_abnormal_xenobiotic_pharmacok1.49053445
41MP0002733_abnormal_thermal_nociception1.47789632
42MP0004742_abnormal_vestibular_system1.37012945
43MP0002928_abnormal_bile_duct1.36518562
44MP0001501_abnormal_sleep_pattern1.36137916
45MP0005389_reproductive_system_phenotype1.35451302
46MP0005084_abnormal_gallbladder_morpholo1.35367436
47MP0000383_abnormal_hair_follicle1.34080456
48MP0002064_seizures1.30368467
49MP0004130_abnormal_muscle_cell1.29250233
50MP0001970_abnormal_pain_threshold1.27987736
51MP0001486_abnormal_startle_reflex1.26750243
52MP0005386_behavior/neurological_phenoty1.23062490
53MP0004924_abnormal_behavior1.23062490
54MP0002572_abnormal_emotion/affect_behav1.22423228
55MP0002234_abnormal_pharynx_morphology1.21759321
56MP0006276_abnormal_autonomic_nervous1.21510993
57MP0000049_abnormal_middle_ear1.19939545
58MP0002067_abnormal_sensory_capabilities1.16013199
59MP0002557_abnormal_social/conspecific_i1.16001857
60MP0003119_abnormal_digestive_system1.15136071
61MP0003787_abnormal_imprinting1.07737323
62MP0002734_abnormal_mechanical_nocicepti1.06355540
63MP0000372_irregular_coat_pigmentation1.06272434
64MP0003252_abnormal_bile_duct1.06000731
65MP0005195_abnormal_posterior_eye1.05094466
66MP0002751_abnormal_autonomic_nervous1.03731717
67MP0000230_abnormal_systemic_arterial1.03556600
68MP0002063_abnormal_learning/memory/cond0.99106513
69MP0003880_abnormal_central_pattern0.98483782
70MP0003635_abnormal_synaptic_transmissio0.94620643
71MP0003718_maternal_effect0.94232561
72MP0003137_abnormal_impulse_conducting0.93304608
73MP0000026_abnormal_inner_ear0.91697399
74MP0001502_abnormal_circadian_rhythm0.91491744
75MP0002095_abnormal_skin_pigmentation0.90700651
76MP0008995_early_reproductive_senescence0.89305377
77MP0003937_abnormal_limbs/digits/tail_de0.88633123
78MP0002752_abnormal_somatic_nervous0.87696398
79MP0001919_abnormal_reproductive_system0.85230792
80MP0002282_abnormal_trachea_morphology0.84335225
81MP0010386_abnormal_urinary_bladder0.83799271
82MP0008775_abnormal_heart_ventricle0.82619190
83MP0001905_abnormal_dopamine_level0.82104037
84MP0004215_abnormal_myocardial_fiber0.81698817
85MP0002277_abnormal_respiratory_mucosa0.80837620
86MP0003938_abnormal_ear_development0.78866924
87MP0005167_abnormal_blood-brain_barrier0.78750035
88MP0001984_abnormal_olfaction0.77917239
89MP0005448_abnormal_energy_balance0.77382715
90MP0002184_abnormal_innervation0.76752521
91MP0000778_abnormal_nervous_system0.76020873
92MP0009250_abnormal_appendicular_skeleto0.75372842
93MP0001963_abnormal_hearing_physiology0.73122164
94MP0001324_abnormal_eye_pigmentation0.72808209
95MP0003698_abnormal_male_reproductive0.72718279
96MP0002163_abnormal_gland_morphology0.71055134
97MP0001440_abnormal_grooming_behavior0.70210082
98MP0005171_absent_coat_pigmentation0.70176580
99MP0008961_abnormal_basal_metabolism0.69793967
100MP0000538_abnormal_urinary_bladder0.69762235

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.67780849
2Congenital stationary night blindness (HP:0007642)4.28396273
3Molar tooth sign on MRI (HP:0002419)4.26013617
4Abnormality of midbrain morphology (HP:0002418)4.26013617
5Genetic anticipation (HP:0003743)4.19454747
6Pancreatic fibrosis (HP:0100732)4.15715277
7True hermaphroditism (HP:0010459)4.01724750
8Pendular nystagmus (HP:0012043)3.57394095
9Nephronophthisis (HP:0000090)3.53660289
10Hyperventilation (HP:0002883)3.45231770
11Birth length less than 3rd percentile (HP:0003561)3.44611171
12Type II lissencephaly (HP:0007260)3.41244379
13Progressive cerebellar ataxia (HP:0002073)3.26931783
14Abnormality of alanine metabolism (HP:0010916)3.08295583
15Hyperalaninemia (HP:0003348)3.08295583
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08295583
17Abnormality of the renal medulla (HP:0100957)3.07312696
18Abnormality of the renal cortex (HP:0011035)3.05416190
19Abolished electroretinogram (ERG) (HP:0000550)2.94623826
20Cystic liver disease (HP:0006706)2.93439804
21Attenuation of retinal blood vessels (HP:0007843)2.90779597
22Tubular atrophy (HP:0000092)2.78506369
23Gaze-evoked nystagmus (HP:0000640)2.73837154
24Keratoconus (HP:0000563)2.72951298
25Increased corneal curvature (HP:0100692)2.72951298
26Large for gestational age (HP:0001520)2.72132637
27Inability to walk (HP:0002540)2.71813102
28Patellar aplasia (HP:0006443)2.70707239
29Medial flaring of the eyebrow (HP:0010747)2.68301014
30Aplasia/Hypoplasia of the patella (HP:0006498)2.65519898
31Chronic hepatic failure (HP:0100626)2.58620099
32Furrowed tongue (HP:0000221)2.49723519
33Sclerocornea (HP:0000647)2.48734015
34Congenital, generalized hypertrichosis (HP:0004540)2.48105338
35Abnormal rod and cone electroretinograms (HP:0008323)2.42879973
36Cerebellar dysplasia (HP:0007033)2.41305834
37Chorioretinal atrophy (HP:0000533)2.39822715
38Abnormal drinking behavior (HP:0030082)2.39795767
39Polydipsia (HP:0001959)2.39795767
40Concave nail (HP:0001598)2.36813465
41Decreased central vision (HP:0007663)2.34499017
42Protruding tongue (HP:0010808)2.33656852
43Clumsiness (HP:0002312)2.30769367
44Progressive inability to walk (HP:0002505)2.29380354
45Lissencephaly (HP:0001339)2.27582880
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26350797
47Anencephaly (HP:0002323)2.18706549
48Abnormality of the renal collecting system (HP:0004742)2.17340024
49Abnormality of the pons (HP:0007361)2.16925406
50Broad-based gait (HP:0002136)2.15536661
51Gait imbalance (HP:0002141)2.11593900
52Male pseudohermaphroditism (HP:0000037)2.10210136
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.08514913
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08319232
55Hemiparesis (HP:0001269)2.06843176
56Hypoplasia of the pons (HP:0012110)2.06793397
57Congenital primary aphakia (HP:0007707)2.06402018
58Severe muscular hypotonia (HP:0006829)2.05864582
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.05213402
60Absent/shortened dynein arms (HP:0200106)2.05213402
61Abnormal biliary tract physiology (HP:0012439)2.05049262
62Bile duct proliferation (HP:0001408)2.05049262
63Congenital hepatic fibrosis (HP:0002612)2.03154019
64Aplasia/Hypoplasia of the uvula (HP:0010293)1.99273561
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.97707466
66Congenital sensorineural hearing impairment (HP:0008527)1.97392819
67Renal cortical cysts (HP:0000803)1.96249758
68Microretrognathia (HP:0000308)1.94697763
69Agitation (HP:0000713)1.94382808
70Nephrogenic diabetes insipidus (HP:0009806)1.92142866
71Tachypnea (HP:0002789)1.88783047
72Duplicated collecting system (HP:0000081)1.87464887
73Decreased circulating renin level (HP:0003351)1.86937364
74Breast hypoplasia (HP:0003187)1.86511248
75Fair hair (HP:0002286)1.84356326
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84340674
77Retinal dysplasia (HP:0007973)1.83678477
78Polyuria (HP:0000103)1.83407443
79Mesangial abnormality (HP:0001966)1.83233533
80Postaxial foot polydactyly (HP:0001830)1.81407469
813-Methylglutaconic aciduria (HP:0003535)1.79883920
82Abnormal respiratory epithelium morphology (HP:0012253)1.79120130
83Abnormal respiratory motile cilium morphology (HP:0005938)1.79120130
84Stomach cancer (HP:0012126)1.79078256
85Bony spicule pigmentary retinopathy (HP:0007737)1.77344417
86Optic nerve hypoplasia (HP:0000609)1.75440649
87Bilateral microphthalmos (HP:0007633)1.75360859
88Genital tract atresia (HP:0001827)1.75057641
89Methylmalonic acidemia (HP:0002912)1.74595820
90Vaginal atresia (HP:0000148)1.74172479
91Absent thumb (HP:0009777)1.72820525
92Impaired smooth pursuit (HP:0007772)1.71369266
93Febrile seizures (HP:0002373)1.70161127
94Abnormal number of erythroid precursors (HP:0012131)1.69449946
95Pachygyria (HP:0001302)1.68011189
96Small hand (HP:0200055)1.67452803
97Rib fusion (HP:0000902)1.66549151
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.66293270
99Absent speech (HP:0001344)1.65562689
100Abnormality of DNA repair (HP:0003254)1.63700888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.53091727
2BMPR1B3.91376067
3ADRBK23.81638204
4ACVR1B3.51559966
5GRK13.23824205
6WNK42.80221985
7ZAK2.76718142
8TLK12.52038647
9INSRR2.46704491
10PINK12.40538720
11WNK32.12904692
12MAP4K22.11602620
13NUAK12.07715693
14DAPK21.94931303
15TAOK31.92370479
16CASK1.91440731
17TGFBR11.72889616
18MAPK131.70449005
19MKNK21.50370922
20ADRBK11.42484604
21OXSR11.37832128
22TXK1.34037511
23MAP3K41.32702090
24MAPK151.17518162
25PNCK1.15080548
26CAMKK21.09514770
27MAPKAPK31.07831904
28TIE11.03872376
29TNIK1.02390089
30PTK2B0.99016373
31STK390.98849698
32PIK3CA0.98483822
33KIT0.96144614
34PAK30.95607590
35MAPKAPK50.91424145
36PRKCG0.87292556
37DYRK20.81191223
38NEK20.78963856
39PRKCE0.76228324
40MKNK10.75270007
41NTRK30.72084128
42MAP2K70.70769815
43VRK10.69959492
44RPS6KA50.69801639
45CAMK1D0.68349447
46TEC0.67909014
47MARK10.67809106
48IKBKB0.67615416
49MAP2K60.65833809
50WNK10.65056744
51BRSK20.63589913
52BCKDK0.63506293
53CSNK1G20.63142700
54STK38L0.61320795
55IRAK10.60855451
56TRPM70.59775836
57STK110.59729971
58CSNK1G10.59042555
59AKT30.56812167
60NME10.56772464
61WEE10.56719027
62CAMKK10.55238486
63NTRK20.54534091
64MUSK0.53420513
65CAMK2A0.52602970
66CAMK10.52409852
67TRIM280.52185482
68PRKCQ0.51378040
69CHUK0.50952148
70PKN10.50485083
71CSNK1G30.50331571
72OBSCN0.49827679
73PRKD20.47554211
74RPS6KA60.47126964
75PHKG10.46146500
76PHKG20.46146500
77CSNK1A1L0.45812867
78PRKACA0.45807707
79STK30.43791230
80FGFR20.43530835
81CHEK20.43025957
82MAP2K10.42805885
83CAMK1G0.42536263
84PRKAA10.41521606
85FLT30.41487308
86PRKAA20.40300718
87ITK0.39968446
88CSNK1A10.39251632
89TNK20.38876159
90CSNK1D0.38860438
91PLK40.38284801
92SGK20.37590674
93ERBB20.35570778
94PRKCI0.34671315
95MELK0.33754957
96PLK20.33649776
97ATR0.33465440
98PRKCH0.33392353
99PRKCA0.32948006
100SIK20.31961744

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.04454952
2Nitrogen metabolism_Homo sapiens_hsa009102.66721095
3Linoleic acid metabolism_Homo sapiens_hsa005912.58862674
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.52843408
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50470361
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.40442991
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38946015
8Selenocompound metabolism_Homo sapiens_hsa004502.37602898
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37309798
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.36867706
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.18758228
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11057462
13Homologous recombination_Homo sapiens_hsa034402.05985746
14Nicotine addiction_Homo sapiens_hsa050332.03970407
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00414405
16Oxidative phosphorylation_Homo sapiens_hsa001901.82021912
17Ether lipid metabolism_Homo sapiens_hsa005651.81294164
18Butanoate metabolism_Homo sapiens_hsa006501.77751395
19RNA polymerase_Homo sapiens_hsa030201.75249980
20Tryptophan metabolism_Homo sapiens_hsa003801.69251017
21Sulfur relay system_Homo sapiens_hsa041221.68541991
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60812919
23Caffeine metabolism_Homo sapiens_hsa002321.60615928
24Fanconi anemia pathway_Homo sapiens_hsa034601.60277210
25Taste transduction_Homo sapiens_hsa047421.56580158
26Basal transcription factors_Homo sapiens_hsa030221.53093648
27One carbon pool by folate_Homo sapiens_hsa006701.40084078
28Morphine addiction_Homo sapiens_hsa050321.37881159
29ABC transporters_Homo sapiens_hsa020101.32359043
30Parkinsons disease_Homo sapiens_hsa050121.29815875
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29074527
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28355892
33Olfactory transduction_Homo sapiens_hsa047401.27486551
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.21714931
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.17532832
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.11876541
37Cardiac muscle contraction_Homo sapiens_hsa042601.09630896
38Chemical carcinogenesis_Homo sapiens_hsa052041.08269424
39Insulin secretion_Homo sapiens_hsa049111.04214367
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03281603
41Protein export_Homo sapiens_hsa030601.01926025
42Serotonergic synapse_Homo sapiens_hsa047261.00586175
43Glutamatergic synapse_Homo sapiens_hsa047240.99776187
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96721464
45Ovarian steroidogenesis_Homo sapiens_hsa049130.96604491
46Peroxisome_Homo sapiens_hsa041460.96064503
47Huntingtons disease_Homo sapiens_hsa050160.95327294
48Retinol metabolism_Homo sapiens_hsa008300.94710083
49GABAergic synapse_Homo sapiens_hsa047270.94543258
50Circadian entrainment_Homo sapiens_hsa047130.93421176
51Calcium signaling pathway_Homo sapiens_hsa040200.92579818
52Arachidonic acid metabolism_Homo sapiens_hsa005900.90643939
53Glycerolipid metabolism_Homo sapiens_hsa005610.89087632
54RNA degradation_Homo sapiens_hsa030180.84454790
55Alzheimers disease_Homo sapiens_hsa050100.84055526
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83445595
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83264399
58Primary immunodeficiency_Homo sapiens_hsa053400.82917134
59Ribosome_Homo sapiens_hsa030100.81707162
60Histidine metabolism_Homo sapiens_hsa003400.80058609
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75277032
62Sulfur metabolism_Homo sapiens_hsa009200.73759657
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73509281
64Propanoate metabolism_Homo sapiens_hsa006400.71464020
65Salivary secretion_Homo sapiens_hsa049700.71223277
66Regulation of autophagy_Homo sapiens_hsa041400.67225872
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66748842
68Fatty acid biosynthesis_Homo sapiens_hsa000610.65598067
69Purine metabolism_Homo sapiens_hsa002300.65470710
70Fat digestion and absorption_Homo sapiens_hsa049750.64451053
71Vitamin digestion and absorption_Homo sapiens_hsa049770.62688940
72Long-term depression_Homo sapiens_hsa047300.59562718
73Dorso-ventral axis formation_Homo sapiens_hsa043200.59422680
74Basal cell carcinoma_Homo sapiens_hsa052170.59132519
75Asthma_Homo sapiens_hsa053100.58838473
76beta-Alanine metabolism_Homo sapiens_hsa004100.56538814
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.56001848
78Hedgehog signaling pathway_Homo sapiens_hsa043400.54957667
79Pyrimidine metabolism_Homo sapiens_hsa002400.52255881
80Dopaminergic synapse_Homo sapiens_hsa047280.51047181
81Mineral absorption_Homo sapiens_hsa049780.50151077
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49453255
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47638876
84Metabolic pathways_Homo sapiens_hsa011000.47505387
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45463184
86Cocaine addiction_Homo sapiens_hsa050300.44125608
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42151213
88Cholinergic synapse_Homo sapiens_hsa047250.41051594
89cAMP signaling pathway_Homo sapiens_hsa040240.40112591
90Nucleotide excision repair_Homo sapiens_hsa034200.39693572
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37695413
92Gastric acid secretion_Homo sapiens_hsa049710.33205014
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32543776
94Oxytocin signaling pathway_Homo sapiens_hsa049210.32068468
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31549851
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31541465
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.30069820
98Collecting duct acid secretion_Homo sapiens_hsa049660.29567949
99Melanoma_Homo sapiens_hsa052180.27547516
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26917821

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